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Hepatocelullar carcinoma

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https://www.readbyqxmd.com/read/27598745/systemic-treatment-for-advanced-hepatocellular-carcinoma-the-search-of-new-agents-to-join-sorafenib-in-the-effective-therapeutic-armamentarium
#1
Andrea Ribeiro de Souza, Maria Reig, Jordi Bruix
INTRODUCTION: Hepatocelullar carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Despite the implementation of screening programs for high-risk individuals, a significant proportion of patients present with advanced disease at the moment of diagnosis. AREAS COVERED: In this review we will focus in the current treatment of advanced HCC, the research that has been done in the past few years, the achievements and failures in this setting and future perspectives...
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27303576/prevalence-of-hbsag-knowledge-and-vaccination-practice-against-viral-hepatitis-b-infection-among-doctors-and-nurses-in-a-secondary-health-care-facility-in-lagos-state-south-western-nigeria
#2
Abdul-Hakeem Olatunji Abiola, Adebukola Bola Agunbiade, Kabir Bolarinwa Badmos, Adenike Olufunmilayo Lesi, Abdulrazzaq Oluwagbemiga Lawal, Quadri Olatunji Alli
INTRODUCTION: Hepatitis B Virus, a highly infectious blood-borne virus poses a major threat to public health globally due to its high prevalence rate and grave consequence in causing liver cirrhosis and hepatocelullar carcinoma, the third cause of cancer death worldwide. The aim is determine the prevalence of HBsAg, knowledge, and vaccination practices against viral hepatitis B infection among doctors and nurses in a health care facility. METHODS: Study design was a descriptive cross-sectional study among all the doctors and nurses in the health care facility...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27084592/unexpected-high-rate-of-early-tumor-recurrence-in-patients-with-hcv-related-hcc-undergoing-interferon-free-therapy
#3
María Reig, Zoe Mariño, Christie Perelló, Mercedes Iñarrairaegui, Andrea Ribeiro, Sabela Lens, Alba Díaz, Ramón Vilana, Anna Darnell, María Varela, Bruno Sangro, José Luis Calleja, Xavier Forns, Jordi Bruix
BACKGROUND & AIMS: The success of direct-acting antivirals (DAA) against hepatitis C is a major breakthrough in hepatology. Until now, however, there are very few data on the effect of hepatitis C virus (HCV) eradication in patients who have already developed hepatocellular carcinoma. METHODS: The study included patients with HCV infection and prior history of treated hepatocellular carcinoma who achieved complete response and lacked 'non-characterized nodules' at the time they underwent anti-HCV treatment with all-oral DAAs in 4 hospitals...
October 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/24898491/-a-case-of-intraventricular-dissemination-arising-from-hepatocelullar-carcinoma-effectively-treated-with-intrathecal-administration-of-methotrexate
#4
Hikaru Oguri, Masaki Miyazawa, Tomoki Nishikawa, Shinichi Hayashi
A 78-year-old man with hepatocellular carcinoma was admitted to our hospital for vertigo after transcatheter arterial chemoembolization. Contrast-enhanced magnetic resonance imaging revealed metastasis in the cerebellar vermis. Although the cerebellar metastasis decreased in size after cyberknife radiotherapy, multiple enhancing nodules appeared in the cerebral ventricles. A diagnosis of intraventricular dissemination from the cerebellar metastatic lesion originating from the hepatocellular carcinoma was made...
June 2014: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/24355442/evaluation-of-five-dna-extraction-methods-for-detection-of-h-pylori-in-formalin-fixed-paraffin-embedded-ffpe-liver-tissue-from-patients-with-hepatocellular-carcinoma
#5
COMPARATIVE STUDY
Elizabeth Rabelo-Gonçalves, Bruna Roesler, Ana Carolina Guardia, Arlete Milan, Natalicia Hara, Cecília Escanhoela, Jazon Almeida, Ilka Boin, José Murilo Zeitune
Since Helicobacter spp. DNA was identified in liver tissue resected from patients with hepatocelullar carcinoma (HCC), researchers have suggested a role of this bacterium in hepatic carcinogenesis. Archives of formalin-fixed, paraffin-embedded (FFPE) tissues represent an extraordinary source for clinical studies providing many advantages. However, DNA extraction from FFPE tissues is laborious, time-consuming and still remains a challenge. The aim of this study was to evaluate five protocols for DNA extraction from FFPE liver obtained from patients with HCC in order to detect Helicobacter pylori DNA...
March 2014: Pathology, Research and Practice
https://www.readbyqxmd.com/read/24159584/comparison-of-international-guidelines-for-noninvasive-diagnosis-of-hepatocellular-carcinoma
#6
REVIEW
Simona Bota, Fabio Piscaglia, Sara Marinelli, Anna Pecorelli, Eleonora Terzi, Luigi Bolondi
The aim of this review is to present the similarities and differences between the latest guidelines for noninvasive diagnosis of hepatocelullar carcinoma (HCC) of American Association for the Study of Liver Diseases (AASLD), European Association for the Study of the Liver (EASL), Asian Pacific Association for the Study of the Liver (APASL), and Japanese Society of Hepatology. All the four guidelines defined a typical HCC vascular pattern as the homogeneous hyperenhancement (wash-in) in the arterial phase followed by wash-out in the venous or late phase...
November 2012: Liver Cancer
https://www.readbyqxmd.com/read/22983078/influence-of-the-sorafenib-patients-assistance-program-on-treatment-compliance-and-overall-survival-of-unresectable-hepatocellular-carcinoma-patients
#7
Laurentius A Lesmana, Rino A Gani, Irsan Hasan, Agus Waspodo, Poernomo Boedi, Melissa S Luwia, Adityawati Ganggaiswari
AIM: to evaluate treatment compliance and survival of patients receiving oral sorafenib in Indonesia. METHODS: a prospective cohort trial. Unresectable Hepatocelullar carcinoma patients receiving Sorafenib in NexPAP program were recruited between October 2008 and September 2011. A historical cohort from Cipto Mangunkusumo Hospital, between 1998 and 2000 was selected to serve as control group. Patients in the control group received symptomatic treatment. Survival analysis was done by the Kaplan-Meier survival curve analysis and the log-rank test...
July 2012: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/21645963/treatment-of-small-hepatocellular-carcinomas-with-us-guided-high-intensity-focused-ultrasound
#8
Hiroyuki Fukuda, Ryu Ito, Masao Ohto, Akio Sakamoto, Eii Karasawa, Taketo Yamaguchi, Norihiro Shinozuka, Hui Zhu, Zhi-Biao Wanga
High-intensity focused ultrasound (HIFU) is a noninvasive method that can cause complete coagulation necrosis without requiring the insertion of any instruments. The purpose of this study was to evaluate the safety and efficacy of HIFU treatment for small liver cancers without performing transcatheter arterial chemoembolization (TACE) or rib resection. HIFU ablation was performed without rib resection or the aid of TACE or percutaneous ethanol injection (PEI) in 12 patients with hepatocelullar carcinoma. The HIFU system (Chongqing Haifu Tech, Chongqing, China) was used under ultrasound guidance...
August 2011: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/21484121/hbv-a-and-hbv-c-genotype-predominance-among-patients-with-chronic-hepatitis-b-virus-infection-in-cebu-city-philippines
#9
Karen S Batoctoy, Tai-Chung Tseng, Jia-Horng Kao, Fidelis E Quiza, Lamberto H Garcia, Judy Lao-Tan
CONTEXT: Chronic Hepatitis B virus (HBV) infection causes significant morbidity and mortality with widespread global distribution. Different genotypes display variations in pathogenesis, disease behavior, and treatment response. HBV/B and HBV/C are prevalent in Asia, but minimal data come from the Philippines. OBJECTIVE: This study is aimed to determine the HBV genotypes of Filipino patients with Chronic HBV infection seen in Cebu City, Philippines and describe the age, sex, viral activity, alanine aminotransferase (ALT) levels and viral load patterns by genotype...
September 2011: Hepatology International
https://www.readbyqxmd.com/read/20149473/clinical-outcomes-of-radiofrequency-ablation-percutaneous-alcohol-and-acetic-acid-injection-for-hepatocelullar-carcinoma-a-meta-analysis
#10
COMPARATIVE STUDY
Giacomo Germani, Maria Pleguezuelo, Kurinchi Gurusamy, Tim Meyer, Graziella Isgrò, Andrew Kenneth Burroughs
BACKGROUND & AIMS: Radiofrequency ablation (RFA) is often the preferred local ablation therapy for hepatocellular carcinoma (HCC). Percutaneous ethanol injection (PEI) is less frequently used, and percutaneous acetic acid injection (PAI) has been mostly abandoned. Robust evidence showing benefit of one therapy versus another is lacking. Our aim was to evaluate the evidence comparing RFA, PEI and PAI using meta-analytical techniques. METHODS: Literature search was undertaken until December 2008 to identify comparative studies evaluating survival, recurrence, complete necrosis of tumour and complications...
March 2010: Journal of Hepatology
https://www.readbyqxmd.com/read/20055297/-transarterial-chemoembolization-in-hepatocellular-carcinoma
#11
M Varga, A Valsamis, I Matia, J Peregrin, E Honsová, M Safanda, M Oliverius
INTRODUCTION: Hepatocelullar carcinoma (HCC) is the fifth most common cancer in the world. It mostly occurs in patients with cirrhosis. In the Czech Republic, about 250 new cases are reported per year. Surgery, i.e. liver resection or transplantation, as the only potentially curable method is possible in 15-20% of them. For the rest, palliative treatment is indicated. This includes ablative methods (radiofrequency ablation, alcoholization), transarterial chemoembolization (TACE), systemic chemotherapy or biological treatment by sorafenib...
August 2009: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/19864776/superiority-of-laparoscopic-guided-needle-biopsy-over-percutaneous-blind-needle-biopsy-in-diagnosing-hepatocellular-carcinoma-associated-with-cirrhosis
#12
A H Al-Saigh
This is a retrospective study of 40 patients clinically suspected of having hepatocellular carcinoma. Group 1 (20) patients underwent laparoscopic Tru-cut needle liver biopsy and Group II (20 patients) underwent percutaneous blind needle liver biopsy. In the first group, in 17 (85%) of the patients, the diagnosis of hepatocellular carcinoma was confirmed by histopathology, direct observation of cirrhosis was seen in 8 (40%) patients, histopathology confirmation of cirrhosis was documented in 6 (35%) patients...
May 1998: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/18351237/-liver-transplatation-for-malignant-tumors-in-children
#13
L F Avila, J L Encinas, N Leal, A Guinea, P García Miguel, P Jara, J Murcia, M Gamez, A Guinea, M López Santamaría, J A Tovar
OBJECTIVE: To analyse our results on liver transplantation (LTX) in primitive malignant unresectable liver tumours in children and discussing its controversial indications in order to our experience. METHODS/PATIENTS: We report 12 patients with ages ranging from 6 months to 14 years old. They had hepatoblastoma (11) and fibrolamellar hepatocelullar carcinoma (1) without cirrhosis. LTX was considered as primary treatment in 10 patients (PRETEXT IV or any grade if extension to retrohepatic cava vein, 3 hepatic veins or porta vein were assessed) and as rescue therapy after recurrence (1) or persistence of unresectable macroscopic rests (2)...
October 2007: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/18303776/-treatment-of-hepatocellular-carcinoma-and-current-situation-in-the-czech-republic
#14
REVIEW
M Oliverius, F Bĕlina, J Novotný, P Studeník, J Pudil, M Ryska
Hepatocelullar carcinoma (HCC) is the commonest primary liver malignacy. Its incidence is increasing worldwide. In the Czech Republic, about 250 new cases are reported per year. The patient's prognosis depends on early diagnosis and initiation of a correct therapeutical procedure. During the decision making process, tumor staging, as well as the chronic liver disease stage, must be considered. Surgery, i.e. liver resection or transplantation, is the only potentially curable method. Other treatment options include chemoembolization, radiofrequency ablation, alcoholization and, currently poorly effective systemic chemotherapy...
December 2007: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/17336170/hepatitis-b-virus-infection
#15
REVIEW
Mei-Hwei Chang
Hepatitis B virus (HBV) infection is a worldwide health problem and may cause acute, fulminant, chronic hepatitis, liver cirrhosis, or hepatocelullar carcinoma (HCC). Infection with HBV in infancy or early childhood may lead to a high rate of persistent infection (25-90%), while the rates are lower if infection occurs during adulthood (5-10%). In most endemic areas, infection occurs mainly during early childhood and mother-to-infant transmission accounts for approximately 50% of the chronic infection cases...
June 2007: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/17211789/liver-transplantation-for-malignant-tumours-in-children
#16
L F Avila, A L Luis, F Hernandez, P Garcia Miguel, P Jara, A M Andres, M Lopez Santamaría, J A Tovar
OBJECTIVE: The object of this study was to analyse our results with liver transplantation (LTX) for primitive malignant unresectable liver tumours in children and to discuss the controversial indications, based on our experience. METHODS/PATIENTS: We report on 12 patients, aged 6 months to 14 years, with hepatic malignant tumours: 11 with hepatoblastoma and 1 with fibrolamellar hepatocelullar carcinoma without cirrhosis. LTX was the primary treatment in 10 patients (PRETEXT IV or any grade, if there was extension to the retrohepatic vena cava, 3 hepatic veins or portal vein) and a rescue therapy after recurrence for 1 and for persistence of unresectable macroscopic residuals in 2 patients...
December 2006: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/16511352/intracellular-localization-and-sustained-prodrug-cell-killing-activity-of-tat-hsvtk-fusion-protein-in-hepatocelullar-carcinoma-cells
#17
Limin Cao, Jin Si, Weiyu Wang, Xiaorong Zhao, Xiaomei Yuan, Huifen Zhu, Xiaolong Wu, Jianzhong Zhu, Guanxin Shen
Gene therapy with nonviral vectors using the suicide gene/prodrug activating system of herpes simplex vi-rus type-1 thymidine kinase (HSV1-TK)/ganciclovir (GCV) is inefficient in killing malignant tumor cells due to two major factors: (a) an unsatisfactory by-stander effect; (b) short-lived expression of the pro-tein. To study the capacity of the protein transduction domain (PTD) of HIV-1 TAT protein to enhance HSV1-TK/GCV cancer gene therapy, we constructed three fusion proteins TAT-TK, TK-TAT and TK. TAT-TK retained as much enzyme activity as TK, whereas that of TK-TAT was much lower...
February 28, 2006: Molecules and Cells
https://www.readbyqxmd.com/read/16187311/direct-activation-of-tgf-beta1-transcription-by-androgen-and-androgen-receptor-complex-in-huh7-human-hepatoma-cells-and-its-tumor-in-nude-mice
#18
Gyesoon Yoon, Ji Yeon Kim, Yang Kyu Choi, Young Suk Won, In Kyoung Lim
Importance of androgen for promotion of hepatocelullar carcinoma (HCC) has long been supported by clinical and experimental evidences. However, mechanisms involved in the carcinogenesis have not yet been fully elucidated. Moreover, unbalanced expression of TGF-beta1 during tumor progression results in prooncogenic rather than growth inhibition. To investigate the effect of androgen on transcriptional regulation of TGF-beta1, we isolated rat TGF-beta1 promoter, based on our previous report (GenBank AF249327), and examined regulation of its promoter activity by dihydrotestosterone in Huh7, LNCaP, and PC3 cells...
February 1, 2006: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/15726654/patients-with-cirrhosis-and-bare-stent-tips-may-have-increased-risk-of-hepatocellular-carcinoma
#19
Rafael Bañares, Oscar Núñez, María Escudero, Cristina Fernández, Javier Vaquero, Inmaculada Beceiro, Antonio Echenagusía, Gerardo Clemente, Leandro Santos
A trend toward a higher incidence of hepatocelullar carcinoma (HCC) in patients with cirrhosis treated with bare-stent transjugular intrahepatic portosystemic shunt (TIPS) has been observed in previous studies. To assess the influence of TIPS as a risk factor for developing HCC, we have compared the incidence of HCC in two retrospective cohorts of patients. The TIPS cohort (n = 138) included patients with cirrhosis who underwent TIPS placement for the treatment of portal hypertension-related complications; the non-TIPS cohort was composed of patients admitted at the hospital at the same time of TIPS insertion who were individually matched 1:1 according to age, sex, Child-Turcotte-Pugh class, and cause of cirrhosis...
March 2005: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/6099570/-evaluation-of-the-methods-of-treatment-of-children-with-liver-neoplasms
#20
COMPARATIVE STUDY
W Czerwiński
Unfavorable prognosis for children with malignant liver tumors, is caused not only because of late diagnosis in this children, but because of imperfet methods of treatment. These methods taken from adults oncology have to be adapted for pediatric patients in front of their differences in biology, pharmacodynamic reactivity and tumor-host relationships in developing organism. Some methods of treatment can be done the same way as in adults, but another (intraarterial treatment) can be used in children with much better results then in adults...
1984: Problemy Medycyny Wieku Rozwojowego
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