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Asiaticoside

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https://www.readbyqxmd.com/read/29719882/differences-in-neuritogenic-activity-and-signaling-activation-of-madecassoside-asiaticoside-and-their-aglycones-in-neuro-2a-cells
#1
Nonthaneth Nalinratana, Duangdeun Meksuriyen, Boonsri Ongpipattanakul
Madecassoside (MS) and asiaticoside (AS) along with their aglycones, madecassic acid (MA) and asiatic acid (AA), are considered the major neuroactive triterpenoid constituents of Centella asiatica . In this study, we aimed to compare MS, AS, MA, and AA for their neurite outgrowth activities and mechanisms in Neuro-2a cells. Immunofluorescent cell staining showed MS and AS significantly increased the percentage of neurite-bearing cells (%NBC) and the neurite length with higher potency than MA and AA. The triterpenoid glycosides induced sustained extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) phosphorylation, while their aglycones activated only transient signaling of ERK1/2...
May 2, 2018: Planta Medica
https://www.readbyqxmd.com/read/29579306/a-novel-multifunctional-c-23-oxidase-cyp714e19-is-involved-in-asiaticoside-biosynthesis
#2
Ok Tae Kim, Yurry Um, Mei Lan Jin, Jang Uk Kim, Daniela Hegebarth, Lucas Busta, Radu C Racovita, Reinhard Jetter
Centella asiatica is widely used as a medicinal plant due to accumulation of the ursane-type triterpene saponins asiaticoside and madecassoside. The molecular structure of both compounds suggests that they are biosynthesized from α-amyrin via three hydroxylations, and respective cytochrome P450-dependent monooxygenases (P450 enzymes) oxidizing the C-28 and C-2α positions have been reported. However, a third enzyme hydroxylating C-23 remained elusive. We previously identified 40,064 unique sequences in the transcriptome of C...
March 22, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29520784/asiaticoside-induces-osteogenic-differentiation-of-human-periodontal-ligament-cells-through-the-wnt-pathway
#3
Atika Resti Fitri, Prasit Pavasant, Supakarn Chamni, Piyamas Sumrejkanchanakij
BACKGROUND: Asiaticoside is a compound isolated from Herb Centella asiatica, which has been shown to promote osteogenic differentiation of human periodontal ligament (hPDL) cells. This study investigated the molecular mechanism underlying the asiaticoside-induced osteogenic differentiation of hPDL cells. METHODS: hPDL cells were incubated with various concentrations of asiaticoside to test cell viability by MTT assay. The mRNA expression levels were analyzed by using quantitative real-time polymerase chain reaction (PCR)...
February 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29460197/anti-inflammatory-effect-of-asiaticoside-on-human-umbilical-vein-endothelial-cells-induced-by-ox-ldl
#4
Li Jing, Wang Haitao, Wang Qiong, Zhu Fu, Zhang Nan, Zhang Xuezheng
Early diagnosis and changes associated with atherosclerosis are crucial in clinical medicine. However, atherosclerosis is a multifactorial disease. Asiaticoside (AA), a triterpenoid derived from Centella asiatica, has anti-inflammatory activity. Endothelium-derived nitric oxide is important in modulating vascular tone in a distinct vessel size-dependent manner; it plays a dominant role in conduit arteries and endothelium-dependent hyperpolarisation in resistance vessels. This study evaluated the effects of AA administration on human umbilical endothelial cells with oxidised low-density lipoprotein-induced inflammation...
April 2018: Cytotechnology
https://www.readbyqxmd.com/read/29438895/piriformospora-indica-cell-wall-extract-as-the-best-elicitor-for-asiaticoside-production-in-centella-asiatica-l-urban-evidenced-by-morphological-physiological-and-molecular-analyses
#5
S Jisha, P R Gouri, K N Anith, K K Sabu
Vascular plants synthesise a multitude of organic molecules or phytochemicals, referred to as "secondary metabolites". These molecules are involved in a variety of roles in the life span of plants, ranging from structural ones to protection. Centella asiatica (L.) Urban has probably been used since prehistoric times and has been reported to have been used for various medicinal and cosmetic purposes. The plant contains several active constituents, of which the most important is asiaticoside, a triterpenoid...
April 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29370854/dual-function-of-active-constituents-from-bark-of-ficus-racemosa-l-in-wound-healing
#6
Nisansala Swarnamali Bopage, G M Kamal Bandara Gunaherath, Kithsiri Hector Jayawardena, Sushila Chandrani Wijeyaratne, Ajita Mahendra Abeysekera, Seneviratne Somaratne
BACKGROUND: Different parts including the latex of Ficus racemosa L. has been used as a medicine for wound healing in the Ayurveda and in the indigenous system of medicine in Sri Lanka. This plant has been evaluated for its wound healing potential using animal models. The aim of this study was to obtain an insight into the wound healing process and identify the potential wound healing active substance/s present in F. racemosa L. bark using scratch wound assay (SWA) as the in-vitro assay method...
January 25, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29351216/in-silico-and-in-vitro-study-of-the-bromelain-phytochemical-complex-inhibition-of-phospholipase-a2-pla2
#7
Fatahiya Mohamed Tap, Fadzilah Adibah Abd Majid, Hassan Fahmi Ismail, Tet Soon Wong, Kamyar Shameli, Mikio Miyake, Nurul Bahiyah Ahmad Khairudin
Phospholipase A2 (Pla2) is an enzyme that induces inflammation, making Pla2 activity an effective approach to reduce inflammation. Therefore, investigating natural compounds for this Pla2 inhibitory activity has important therapeutic potential. The objective of this study was to investigate the potential in bromelain-phytochemical complex inhibitors via a combination of in silico and in vitro methods. Bromelain-amenthoflavone displays antagonistic effects on Pla2. Bromelian-asiaticoside and bromelain-diosgenin displayed synergistic effects at high concentrations of the combined compounds, with inhibition percentages of more than 70% and 90%, respectively, and antagonistic effects at low concentrations...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29210992/characterization-of-the-asiatic-acid-glucosyltransferase-ugt73ah1-involved-in-asiaticoside-biosynthesis-in-centella-asiatica-l-urban
#8
Ok Tae Kim, Mei Lan Jin, Dae Young Lee, Reinhard Jetter
Centella asiatica (L.) Urban contains two ursane-type triterpene saponins, asiaticoside and madecassoside, as major secondary metabolites. In order to select candidate genes encoding UDP-glucosyltransferases (UGTs) involved in asiaticoside biosynthesis, we performed transcriptomic analysis of leaves elicited by methyl jasmonate (MeJA). Among the unigenes, 120 isotigs and 13 singletons of unique sequences were annotated as UGTs, including 37 putative full-length cDNAs, and 15 of the putative UGT genes were named according to the UGT committee nomenclature protocols...
December 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29108653/effect-of-asiaticoside-on-the-healing-of-skin-wounds-in-the-carp-cirrhinus-mrigala-an-immunohistochemical-investigation
#9
Neeraj Verma, Usha Kumari, Swati Mittal, Ajay Kumar Mittal
In the present study effect of asiaticoside, on healing of skin wounds in Cirrhinus mrigala is reported. Skin wound, approx. 2mm in diameter was excised using sterile disposable biopsy punch. Immediately after infliction of the wound, epidermis from wound edge starts migrating as thin sheet toward wound gap. Fronts of migrating epidermis gradually advance, and results in complete epithelialization of wound. Experiments were conducted for 30days and fishes were divided into control, sham, vehicle control and asiaticoside treated groups...
December 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28891650/asiaticoside-mitigates-the-allergic-inflammation-by-abrogating-the-degranulation-of-mast-cells
#10
Jing Zhi Jiang, Jing Ye, Guang Yu Jin, Hong Mei Piao, Hong Cui, Ming Yu Zheng, Jin Shi Yang, Nan Che, Yun Ho Choi, Liang Chang Li, Guang Hai Yan
The effects of asiaticoside (AS) on allergic responses mediated by mast cells were investigated. AS showed no obvious cytotoxicity on RPMCs (rat peritoneal mast cells). AS reduced the intracellular calcium in RPMCs and deprived the histamine release and degranulation. AS also decreased the generation of antigen-induced tumor necrosis factor α, interleukin (IL)-4, IL-8, and IL-1β in RBL-2H3 cells sensitized by IgE. The suppression of AS on pro-inflammatory cytokines was related with the activation of the intracellular FcεRI and the inhibition of the nuclear factor-κB signaling pathway...
September 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28716424/molecular-cloning-of-an-ester-forming-triterpenoid-udp-glucose-28-o-glucosyltransferase-involved-in-saponin-biosynthesis-from-the-medicinal-plant-centella-asiatica
#11
Fernanda de Costa, Carla J S Barber, Yeon-Bok Kim, Darwin W Reed, Haixia Zhang, Arthur G Fett-Neto, Patrick S Covello
Triterpene saponins include bioactive compounds with structures consisting of triterpene aglycones (sapogenins) and one or more sugar moieties linked through acetal or ester glycosidic linkages at one or more sites. Centella asiatica (L.) Urban is a medicinal plant that contains bioactive ursane-type saponins, such as madecassoside and asiaticoside. In this work, glucosylation of triterpenoids in C. asiatica was investigated starting with plant extracts. An enzyme capable of glucosylating asiatic and madecassic acids was partially purified...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28651288/development-of-a-high-performance-liquid-chromatographic-method-for-asiaticoside-quantification-in-different-skin-layers-after-topical-application-of-a-centella-asiatica-extract
#12
Priscila Bianca Rodrigues da Rocha, Bruno Dos Santos Souza, Lígia Marquez Andrade, Ricardo Neves Marreto, Eliana Martins Lima, Stephânia Fleury Taveira
The topical application of Centella asiatica extract has been commonly used for many different purposes but especially for cosmetic use in the treatment of gynoid lipodystrophy. Asiaticoside, the most active component in this extract, is responsible for its therapeutic activities. However, little is known to date about asiaticoside skin penetration. Thus, an analytical method for asiaticoside quantification in different skin layers after the topical application of C. asiatica extract was developed and skin permeation studies were performed with the plant extract to apply the analytical method developed...
December 2017: Planta Medica
https://www.readbyqxmd.com/read/28378604/pva-peg-physically-cross-linked-hydrogel-film-as-a-wound-dressing-experimental-design-and-optimization
#13
Afnan Sh Ahmed, Uttam Kumar Mandal, Muhammad Taher, Deny Susanti, Juliana Md Jaffri
The development of hydrogel films as wound healing dressings is of a great interest owing to their biological tissue-like nature. Polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogels loaded with asiaticoside, a standardized rich fraction of Centella asiatica, were successfully developed using the freeze-thaw method. Response surface methodology with Box-Behnken experimental design was employed to optimize the hydrogels. The hydrogels were characterized and optimized by gel fraction, swelling behavior, water vapor transmission rate and mechanical strength...
April 5, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28352309/asiaticoside-ameliorates-%C3%AE-amyloid-induced-learning-and-memory-deficits-in-rats-by-inhibiting-mitochondrial-apoptosis-and-reducing-inflammatory-factors
#14
Zhuo Zhang, Xiaobin Li, Duo Li, Mao Luo, Yongjie Li, Li Song, Xian Jiang
The present study aimed to investigate the effects of asiaticoside (AS) on the pathology and associated mechanisms of β-amyloid (Aβ)-induced Alzheimer's disease (AD) in rats. An AD rat model was established by lateral intracerebroventricular injection of Aβ 1-42 oligomers. Learning and memory function were evaluated by Morris water maze (MWM) test. In addition, hematoxylin and eosin (H&E) staining, transmission electron microscopy (TEM), immunohistochemistry, ELISA and western blot analysis were performed to evaluate the disease pathogenesis...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28346732/asiaticoside-hinders-the-invasive-growth-of-keloid-fibroblasts-through-inhibition-of-the-gdf-9-mapk-smad-pathway
#15
Xin Wu, Difei Bian, Yannong Dou, Zhunan Gong, Qian Tan, Yufeng Xia, Yue Dai
Higher expression of growth differentiation factor-9 (GDF-9) in keloids compared with hypertrophic scars and normal skin tissues has been reported recently. The present study was performed to investigate the role of GDF-9 in keloid pathogenesis, and to elucidate its implication for asiaticoside in the keloid management. The data showed that GDF-9 could enhance the proliferation, migration, and invasion of keloid fibroblasts (KFs), while it only slightly elevated collagen expression, indicating that the effect of GDF-9 was opposite to that of TGF-β1...
August 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28263826/borneol-enhances-the-antidepressant-effects-of-asiaticoside-by-promoting-its-distribution-into-the-brain
#16
Tianheng Hou, Xiaobo Li, Chongsheng Peng
Asiaticoside (AS) has antidepressant effects, with poor druggability characterized with inaccessibility into the brain. Here, we assessed AS distribution in the asiaticoside-borneol formula (FAB), with AS administrated orally. High performance liquid chromatography (HPLC) was applied for AS detection. The antidepressant effects of both FAB and AS were evaluated. Rats were subjected to behavioral despair paradigms and chronic unpredictable stress model (CUS) after acute and chronic drug administration, respectively...
April 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28238857/asiaticoside-attenuation-of-rotenone-induced-oxidative-burden-in-a-rat-model-of-hemiparkinsonism-by-maintaining-the-phosphoinositide-mediated-synaptic-integrity
#17
Margabandhu Gopi, Vanisree Arambakkam Janardhanam
Asiaticoside (AS), a triterpenoid saponin isolated from the Indian medicinal herb Centella asiatica is known to exert a neuroprotective effect by attenuating the neurobehavioral, neurochemical and pathological changes in animal models. However, its potential neuroprotection in rotenone-induced hemiparkinsonism which implicates phospholipid-mediated neurotransmission remains unclear. Therefore, we have investigated the neuroprotective effects of AS in rat model of ROT-infused hemiparkinsonism with respect to phosphoinositides-assisted cytodynamics and synaptic function...
April 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28024288/asiaticoside-protects-cochlear-hair-cells-from-high-glucose-induced-oxidative-stress-via-suppressing-ages-rage-nf-%C3%AE%C2%BAb-pathway
#18
Ying Xing, Qiuhe Ji, Xiaomiao Li, Jie Ming, Nana Zhang, Dingjun Zha, Ying Lin
Asiaticoside (AC) has been known to have anti-oxidative activity, however, the effect of AC on the progression of high glucose-induced hearing loss has not been studied. This study aims to analyze the effect of AC on cochlear hair cells under the treatment of high glucose in vitro and the hearing function in vivo. The results of MTT showed that high glucose decreased the activity of HEI-OC1 cells, but AC increased the activity of HEI-OC1 cells compared with high glucose group. The results of flow cytometry showed that AC decreased the degree of apoptosis induced by high levels of glucose...
February 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28001462/comparative-pharmacokinetics-between-madecassoside-and-asiaticoside-presented-in-a-standardised-extract-of-centella-asiatica-eca-233-and-their-respective-pure-compound-given-separately-in-rats
#19
Patcharaporn Hengjumrut, Tosapol Anukunwithaya, Mayuree H Tantisira, Boonyong Tantisira, Phisit Khemawoot
1. ECa 233, the standardised extract of Centella asiatica, contains not less than 80% triterpenoid glycosides, in a madecassoside:asiaticoside ratio of 1.5 (±0.5):1. 2. The pharmacokinetic comparison of madecassoside and asiaticoside was performed in rats following intravenous and oral administration of ECa 233, or an equivalent dose of the individual compounds. Blood, tissues, urine and faeces were collected after dosing to determine drug and metabolite levels using liquid chromatography-tandem mass spectrometry...
January 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27992940/pharmacokinetics-of-a-standardized-extract-of-centella-asiatica-eca-233-in-rats
#20
Tosapol Anukunwithaya, Mayuree H Tantisira, Boonyong Tantisira, Phisit Khemawoot
ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intravenously or orally administered at doses from 50 to 200 mg/kg. Plasma, tissues, urine, and feces were collected at time points from 0 to 48 h after dosing. The levels of madecassoside and asiaticoside, as well as their postulated triterpenic metabolites, madecassic acid and asiatic acid, in biological samples, were simultaneously measured by liquid chromatography-tandem mass spectrometry...
May 2017: Planta Medica
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