keyword
MENU ▼
Read by QxMD icon Read
search

Asiatic acid

keyword
https://www.readbyqxmd.com/read/29805609/asiatic-acid-prevents-the-development-of-interstitial-lung-disease-in-a-hypochlorous-acid-induced-mouse-model-of-scleroderma
#1
Xiaoru Xia, Caijun Dai, Hua Yu, Xiaoying Huang, Ali Chen, Yingxia Tan, Liangxing Wang
Interstitial lung disease is the most common complication of systemic sclerosis (SSc) and is associated with a high rate of mortality. Due to the complex pathogenesis of SSc, the therapies currently available remain limited. In the present study, the effect of asiatic acid (AA) on SSc-associated pulmonary fibrosis (PF) and its association with the transforming growth factor-β1 (TGF-β1)/Smad2/3 signaling pathway were evaluated. A hypochlorous acid (HOCl)-induced model of SSc was used to evaluate the therapeutic effect of AA on PF in SSc, where AA was administered to SSc mice by gavage...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29805556/asiatic-acid-inhibits-proliferation-migration-and-induces-apoptosis-by-regulating-pdcd4-via-the-pi3k-akt-mtor-p70s6k-signaling-pathway-in-human-colon-carcinoma-cells
#2
Yajuan Hao, Jiawei Huang, Yun Ma, Wancheng Chen, Qin Fan, Xuegang Sun, Meng Shao, Hongbing Cai
Previous studies have demonstrated that asiatic acid (AA), the major component of Centella asiatica , is able to meditate cytotoxic and anticancer effects on various types of carcinoma cells. In order to investigate the molecular mechanism that underlies the antitumor effect of AA, the present study investigated the effects of AA on proliferation, migration and apoptosis of SW480 and HCT116 colon cancer cells. Viability and changes in cell morphology in the cells were assessed by MTT assay and transmission electron microscopy, respectively...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29768255/asiatic-acid-aa-sensitizes-multidrug-resistant-human-lung-adenocarcinoma-a549-ddp-cells-to-cisplatin-ddp-via-downregulation-of-p-glycoprotein-mdr1-and-its-targets
#3
Qilai Cheng, Meixiang Liao, Haibo Hu, Hongliang Li, Longhuo Wu
BACKGROUND/AIMS: P-glycoprotein (P-gp, i.e., MDR1) is associated with the phenotype of multidrug resistance (MDR) and causes chemotherapy failure in the management of cancers. Searching for effective MDR modulators and combining them with anticancer drugs is a promising strategy against MDR. Asiatic acid (AA), a natural triterpene isolated from the plant Centella asiatica, may have an antitumor activity. The present study assessed the reversing effect of AA on MDR and possible molecular mechanisms of AA action in MDR1-overexpressing cisplatin (DDP)-resistant lung cancer cells, A549/DDP...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29752110/evaluation-of-nano-hydrogel-composite-based-on-gelatin-ha-cs-suffused-with-asiatic-acid-zno-and-cuo-nanoparticles-for-second-degree-burns
#4
Thanusha A V, Amit Kumar Dinda, Veena Koul
In the present work, a hydrogel platform composed of biopolymer gelatin, and glycosaminoglycan's (Hyaluronic acid and Chondroitin sulfate) incorporated with Asiatic acid (a triterpenoid) and nanoparticles (Zinc oxide and Copper oxide) has been designed and developed to find out the efficacy of healing in second degree burn wounds in Wistar rats. The developed hydrogel composite has been characterized by physico-chemical methods such as; SEM, swelling, mechanical strength, degradation and drug release kinetics...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29719882/differences-in-neuritogenic-activity-and-signaling-activation-of-madecassoside-asiaticoside-and-their-aglycones-in-neuro-2a-cells
#5
Nonthaneth Nalinratana, Duangdeun Meksuriyen, Boonsri Ongpipattanakul
Madecassoside (MS) and asiaticoside (AS) along with their aglycones, madecassic acid (MA) and asiatic acid (AA), are considered the major neuroactive triterpenoid constituents of Centella asiatica . In this study, we aimed to compare MS, AS, MA, and AA for their neurite outgrowth activities and mechanisms in Neuro-2a cells. Immunofluorescent cell staining showed MS and AS significantly increased the percentage of neurite-bearing cells (%NBC) and the neurite length with higher potency than MA and AA. The triterpenoid glycosides induced sustained extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) phosphorylation, while their aglycones activated only transient signaling of ERK1/2...
May 2, 2018: Planta Medica
https://www.readbyqxmd.com/read/29702278/asiatic-acid-attenuates-ccl-4-induced-liver-fibrosis-in-rats-by-regulating-the-pi3k-akt-mtor-and-bcl-2-bax-signaling-pathways
#6
Liwen Wei, Qingshan Chen, Aijie Guo, Jie Fan, Rong Wang, Hai Zhang
Liver fibrosis is a major pathological feature of chronic liver diseases, and effective therapies are limited at present. Asiatic acid (AA) is a triterpenoid isolated from Centella asiatica, which exhibits efficient anti-inflammatory and anti-oxidative activities. In this study, we attempted to evaluate the potential therapeutic effect of AA on CCl4 -induced liver fibrosis in rats and to investigate the underlying molecular mechanisms. Liver fibrosis-related indexes including body weight, biochemical parameters, histological changes, the mRNA expression levels of inflammatory cytokines and biomarkers, and changes in the expression of related proteins in liver tissue were assessed...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29671714/blood-chemistry-reference-values-for-free-ranging-asiatic-black-bears-ursus-thibetanus-by-season-age-and-sex
#7
Jeong-Jin Yang, Dong-Hyuk Jeong, Yoon-Kyu Lim
Physiological characteristics, such as blood chemistry values, are valuable for evaluating the health of the animals. To our knowledge, these values have never been reported for the free-ranging Asiatic black bear ( Ursus thibetanus; ABB). Thus, 28 blood chemistry values from 50 free-ranging ABBs captured in Jirisan National Park, Republic of Korea, from 2005 to 2016 were evaluated. The aim of this study was to establish blood chemistry reference values for the free-ranging ABBs during both the hibernating and nonhibernating seasons...
April 19, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29670362/antiangiogenic-effects-of-aa-pme-on-huvecs-in-vitro-and-zebrafish-in-vivo
#8
Yue Jing, Gang Wang, Qi Xiao, Yachun Zhou, Yingjie Wei, Zhunan Gong
Angiogenesis plays a vital role in many physiological and pathological processes and several diseases are connected with its dysregulation. Asiatic acid (AA) has demonstrated anticancer properties and we suspect this might be attributable to an effect on angio-genesis. A modified derivative of AA, N-(2α,3β,23-acetoxyurs-12-en-28-oyl)-L-proline methyl ester (AA-PMe), has improved efficacy over its parent compound, but its effect on blood vessel development remains unclear. Methods: In this study, we investigated the antiangiogenic activity of AA and AA-PMe in zebrafish embryos and human umbilical vein endothelial cells (HUVECs)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29599924/asiatic-acid-attenuates-lipopolysaccharide-induced-injury-by-suppressing-activation-of-the-notch-signaling-pathway
#9
Xiong Yuyun, Cheng Xi, Yin Qing, Xia Lin, Rui Ke, Sun Bingwei
Sepsis is a severe multisystem disease with high mortality rates and limited treatment options. However, advances during the last decade have opened opportunities to develop novel therapeutic strategies. The Notch signaling pathway plays a critical role in inflammation, and its inhibition offers an avenue to treat inflammatory diseases, such as sepsis. Asiatic acid (AA), a triterpenoid isolated from Centella asiatica, reportedly exerts anti-oxidant, anti-tumor, and anti-inflammatory effects, but its mechanisms remain unclear...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29501767/centella-asiatica-ameliorates-diabetes-induced-stress-in-rat-tissues-via-influences-on-antioxidants-and-inflammatory-cytokines
#10
Bubuya Masola, Oluwafemi O Oguntibeju, Ayodeji B Oyenihi
Centella asiatica (L.) Urban (Family: Apiaceae) is a perennial herb that has been used to elevate mood, improve memory, treat wounds and manage kidney-related ailments in African traditional medicine practice. This study evaluated the potential benefits of C. asiatica (CA) on diabetes-induced stress in kidney and brain of rats. Following the induction of diabetes mellitus (DM), rats were orally treated with vehicle, CA or Metformin daily for 14 days. After treatment, renal and brain levels of inflammatory cytokines, TNF-α, IFN-γ, IL-4, and IL-10 were assessed...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29467846/asiatic-acid-attenuates-high-fat-diet-induced-impaired-spermatogenesis
#11
Xi-Li Miao, Gui-Min Gao, Lei Jiang, Rui Xu, Da-Peng Wan
Testicular cell apoptosis is associated with impaired spermatogenesis. It has been reported that Asiatic acid (AA) may suppress apoptosis. However, little is known about the effect of AA on high-fat diet (HFD)-induced impairment of spermatogenesis. The aim of the present study was to determine whether AA protects against HFD-induced impairment of spermatogenesis. Sprague-Dawley rats were randomly divided into three groups: Control group, HFD group and AA (50 mg/kg) + HFD group. Rats fed an HFD were orally administered with AA (50 mg/kg) daily for 12 weeks, and blood samples, testis and epididymis were harvested for further analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29451865/flavonoids-and-triterpenes-from-combretum-fragrans-with-anti-inflammatory-antioxidant-and-antidiabetic-potential
#12
Amadou Dawé, Marius Mbiantcha, Fawai Yakai, Almas Jabeen, Muhammad Shaiq Ali, Mehreen Lateef, Bonaventure Tchaleu Ngadjui
Despite the well-documented benefits of Combretum fragrans in Cameroon, only few scientific works have been done on it. In this study we isolated eight compounds from the leaves extract of C. fragrans: velutin (1), belamcanidin (2), cirsilineol (3), cirsimaritin (4), 3β-acetoxy-20,24-epoxy-11,25-hydroxy-dammarane (5), combretin A (6), combretin B (7) and a mixture of arjunolic acid (8a) and asiatic acid (8b). Compounds 6 and 7 presented potent anti-inflammatory, antioxidant and antidiabetic activities. Compounds 1, 3, 5 and the mixture of 8a and 8b were significantly active, and compounds 2 and 4 presented moderate activity for reactive oxygen species inhibitory and free-radical scavenging...
April 25, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29369796/asiatic-acid-inhibits-lps-induced-inflammatory-response-in-endometrial-epithelial-cells
#13
Shou-Yan Cao, Wei Wang, Fang-Fang Nan, Yan-Ni Liu, Shuang-Yan Wei, Fang-Fang Li, Li Chen
Accumulating evidence indicates that asiatic acid, a natural triterpene isolated from Centella asiatica, has anti-inflammatory activity. However, the anti-inflammatory effects of asiatic acid on LPS-stimulated endometrial epithelial cells and the involved molecular pathways have not been completely elucidated. In the present study, we evaluated the effects of asiatic acid on LPS-induced inflammatory response in endometrial epithelial cells. Mouse endometrial epithelial cells were treated with asiatic acid and stimulated with LPS...
March 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29361877/pharmacological-review-on-asiatic-acid-and-its-derivatives-a-potential-compound
#14
Junwei Lv, Alok Sharma, Ting Zhang, Yuchen Wu, Xianting Ding
Natural triterpenes represent a group of pharmacologically active and structurally diverse organic compounds. The focus on these phytochemicals has been enormous in the past few years, worldwide. Asiatic acid (AA), a naturally occurring pentacyclic triterpenoid, is found mainly in the traditional medicinal herb Centella asiatica. Triterpenoid saponins, which are the primary constituents of C. asiatica, are commonly believed to be responsible for their extensive therapeutic actions. Published research work has described the molecular mechanisms underlying the various biological activities of AA and its derivatives, which vary for each chronic disease...
April 2018: SLAS Technology
https://www.readbyqxmd.com/read/29357733/effects-of-glycyrrhizin-on-the-pharmacokinetics-of-asiatic-acid-in-rats-and-its-potential-mechanism
#15
Ling Guo, Ying Cui, Kaijun Hao
CONTEXT: Asiatic acid has been reported to possess a wide range of pharmacological activities. OBJECTIVE: This study investigates the effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism. MATERIALS AND METHODS: The pharmacokinetics of orally administered asiatic acid (20 mg/kg) with or without glycyrrhizin pretreatment (100 mg/kg/day for seven days) were investigated using a LC-MS method. Additionally, the Caco-2 cell transwell model and rat liver microsome incubation systems were used to investigate the potential mechanism of glycyrrhizin's effects on the pharmacokinetics of asiatic acid...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29354820/asiatic-acid-suppresses-neuroinflammation-in-bv2-microglia-via-modulation-of-the-sirt1-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Yisong Qian, Zhaochen Xin, Yanni Lv, Ziwei Wang, Li Zuo, Xiang Huang, Yunman Li, Hong-Bo Xin
Asiatic acid, a triterpenoid derived from Centella asiatica, has been found to exhibit multiple bioactivities. In this study, we investigated the effects of asiatic acid on lipopolysaccharide (LPS)-induced neuroinflammation and explored the mechanism of its action in BV2 microglia. We found that asiatic acid (0.1 to 100 μM) treatment significantly attenuated nitric oxide (NO) production and inhibited inducible nitric oxide synthase (iNOS) expression in a concentration-dependent manner following LPS exposure...
February 21, 2018: Food & Function
https://www.readbyqxmd.com/read/29304559/synthesis-and-antitumor-activity-evaluation-of-asiatic-acid-derivatives-as-survivin-inhibitor
#17
Yan-Qiu Meng, Hua-Bo Cui, Lei Li, Wei-Chen Zhang, Hong-Shuang Pan, Ting-Ting Yu, Wei Li
A series of asiatic acid derivatives were synthesized and their cytotoxicities in vitro against two cancer cell lines (HepG2 and SGC7901) were evaluated by MTT assay. The results showed that compounds I2 , I6 , and II6 have more potent anticancer activity than that of the positive control drug paclitaxel. The interactions between the compounds I2 , I6 , and II6 and survivin were also studied by docking simulations.
January 5, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29228978/asiatic-acid-attenuates-methamphetamine-induced-neuroinflammation-and-neurotoxicity-through-blocking-of-nf-kb-stat3-erk-and-mitochondria-mediated-apoptosis-pathway
#18
Ji-Hyun Park, Young Ho Seo, Jung-Hee Jang, Chul-Ho Jeong, Sooyeun Lee, Byoungduck Park
BACKGROUND: Methamphetamine (METH) is a commonly abused drug that may result in neurotoxic effects. Recent studies have suggested that involvement of neuroinflammatory processes in brain dysfunction is induced by misuse of this drug. However, the mechanism underlying METH-induced inflammation and neurotoxicity in neurons is still unclear. In this study, we investigated whether asiatic acid (AA) effected METH-mediated neuroinflammation and neurotoxicity in dopaminergic neuronal cells. And we further determined whether the effect involved in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) pathway...
December 11, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29210992/characterization-of-the-asiatic-acid-glucosyltransferase-ugt73ah1-involved-in-asiaticoside-biosynthesis-in-centella-asiatica-l-urban
#19
Ok Tae Kim, Mei Lan Jin, Dae Young Lee, Reinhard Jetter
Centella asiatica (L.) Urban contains two ursane-type triterpene saponins, asiaticoside and madecassoside, as major secondary metabolites. In order to select candidate genes encoding UDP-glucosyltransferases (UGTs) involved in asiaticoside biosynthesis, we performed transcriptomic analysis of leaves elicited by methyl jasmonate (MeJA). Among the unigenes, 120 isotigs and 13 singletons of unique sequences were annotated as UGTs, including 37 putative full-length cDNAs, and 15 of the putative UGT genes were named according to the UGT committee nomenclature protocols...
December 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29196105/asiatic-acid-ameliorates-hepatic-ischemia-reperfusion-injury-in-rats-via-mitochondria-targeted-protective-mechanism
#20
Yapeng Lu, Huiwen Kan, Ying Wang, Dan Wang, Xueting Wang, Jing Gao, Li Zhu
It has been proved that asiatic acid (AA) directly targets mitochondria and acts as a mild mitochondrial uncoupler. In this study, we aim to investigate the protective effects of AA against ischemia/reperfusion (I/R)-induced liver injury in rats and some underlying mechanisms involved were elucidated. The results showed that 50mg/kg AA pre-treatment significantly reduced I/R-induced liver damage, characterized by the decreased release of aspartate aminotransferase (AST) and TNF-α. Furthermore, AA pre-treatment dramatically inhibited the production of MDA and increased the hepatic SOD, catalase activities and GSH levels in liver tissue of I/R rats which indicated that AA ameliorated I/R-induced liver damage by reducing oxidative stress...
January 1, 2018: Toxicology and Applied Pharmacology
keyword
keyword
99965
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"