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Asiatic acid

Jinjin Lin, Hui Jiang, Xianting Ding
To identify alternatives of nerve growth factor, which could promote NF68 protein expression and contribute toward neuronal differentiation, five compounds namely: asiatic acid, madecassic, madecassoside, quercetin, and isoquercetin, obtained from Centella asiatica, were examined for their neuronal differentiation effects on PC12 cells. C. asiatica has been applied as an effective herbal medicine for the treatment of various diseases, including depression. According to a statistical design of experiments, both single compound and compound combinations were evaluated...
January 1, 2017: Neuroreport
Qiang Liu, Youping Sun, Jinzheng Chen, Peiwang Li, Changzhu Li, Genhua Niu, Lijuan Jiang
BACKGROUND: Symplocos paniculata, asiatic sweetleaf or sapphire berry, is a widespread shrub or small tree from Symplocaceae with high oil content and excellent fatty acid composition in fruit. It has been used as feedstocks for biodiesel and cooking oil production in China. Little transcriptome information is available on the regulatory molecular mechanism of oil accumulation at different fruit development stages. RESULTS: The transcriptome at four different stages of fruit development (10, 80,140, and 170 days after flowering) of S...
November 16, 2016: BMC Genomics
Changzheng Gao, Fen Wang, Zhiqiang Wang, Jing Zhang, Xiangjun Yang
The lactate signaling cascade has recently been linked to mitochondrial energy metabolism and cardiomyocyte apoptosis in several cardiovascular diseases. Asiatic acid (AA) exhibits a variety of pharmacological effects, including antioxidant and anti-apoptotic effects. In this study, we investigated the protective effects of AA against the lactate-induced apoptosis of cardiomyocytes, as well as its mechanisms of action. Neonatal rat cardiomyocytes were pre-treated with 20 µM AA for 24 h, followed by exposure to 20 mM lactate for a further 24 h...
October 20, 2016: International Journal of Molecular Medicine
Banita Pattnaik, Jerripothula K Lakshmi, Rachineni Kavitha, Bharatam Jagadeesh, Debanjan Bhattacharjee, Nishant Jain, Uppuluri V Mallavadhani
Some novel chemically modified frameworks of ursolic acid have been designed and synthesized. The key step was the cycloaddition of azidopropyl-3β-hydroxy-urs-12-en-28-oate with the appropriate C28 propargyl esters of ursolic, corosolic, asiatic, oleanolic, and betulinic acid under Click reaction conditions, and the products were obtained in 74-84% yields. In view of their intriguing structural diversity, they have been subjected to detailed 1D and 2D NMR studies and their structures are thoroughly assigned...
October 20, 2016: Journal of Asian Natural Products Research
Dong-Hyuk Jeong, Jeong-Jin Yang, Seong-Hoon Seok, Dong-Joo Song, Seong-Chan Yeon
The objective of this study was to determine the dose-dependent effects of isoflurane on various cardiovascular parameters and the stable range of isoflurane concentrations in Asiatic black bears (Ursus thibetanus). Seven Asiatic black bears were intramuscularly injected with medetomidine, zolazepam, and tiletamine (MZT) to induce anesthesia and anesthesia was maintained by administering isoflurane in 100% oxygen (4 l/min) without mechanical ventilation. Several cardiovascular parameters were measured at five end-tidal isoflurane concentrations (0...
September 30, 2016: Journal of Veterinary Medical Science
Xiangyu Wang, Qi Sun, Zhonghua Ye, Ying Hua, Na Shao, Yanli Du, Qiwei Zhang, Chengsong Wan
An avian-origin influenza H7N9 virus epidemic occurred in China in 2013-2014, in which >422 infected people suffered from pneumonia, respiratory distress syndrome and septic shock. H7N9 viruses belong to the H7 subtype of avian-origin influenza viruses (AIV-H7). Hemagglutinin (HA) is a vital membrane protein of AIV that has an important role in host recognition and infection. The epitopes of HA are significant determinants of the regularity of epidemic and viral mutation and recombination mechanisms. The present study aimed to predict the conserved B-cell epitopes of AIV-H7 HA using a bioinformatics approach, including the three most effective epitope prediction softwares available online: Artificial Neural Network based B-cell Epitope Prediction (ABCpred), B-cell Epitope Prediction (BepiPred) and Linear B-cell Epitope Prediction (LBtope)...
October 2016: Experimental and Therapeutic Medicine
Roxana A Roeschlin, María A Favaro, María A Chiesa, Sergio Alemano, Adrián A Vojnov, Atilio P Castagnaro, María P Filippone, Frederick G Gmitter, José Gadea, María R Marano
Xanthomonas citri ssp. citri (X. citri) is the causal agent of Asiatic citrus canker, a disease that seriously affects most commercially important Citrus species worldwide. We have previously identified a natural variant, X. citri A(T) , that triggers a host-specific defense response in Citrus limon. However, the mechanisms involved in this canker disease resistance are unknown. In this work, the defense response induced by X. citri A(T) was assessed by transcriptomic, physiological and ultrastructural analyses and the effects on bacterial biofilm formation were monitored in parallel...
September 20, 2016: Molecular Plant Pathology
G A Mavondo, B N Mkhwananzi, M V Mabandla, C T Musabayane
BACKGROUND: Current malaria treatment is either "anti-parasitic", "anti-infectivity" or both without addressing the pathophysiological derangement (anti-disease aspect) associated with the disease. Asiatic acid is a natural phytochemical with oxidant, antioxidant and anti-inflammatory properties whose effect on malarial and accompanying pathophysiology are yet to be investigated. Asiatic acid influence in P. berghei-infected Sprague Dawley rats on %parasitaemia and malarial anaemia were investigated...
2016: BMC Complementary and Alternative Medicine
Wu Jiang, Maoqiang Li, Fan He, Wangxiang Yao, Zhenyu Bian, Xuepeng Wang, Liulong Zhu
The biological effects of asiatic acid (AA) on spinal cord injury (SCI)-induced acute lung injury (ALI) have not been investigated. We aimed to investigate the therapeutic efficacy and molecular mechanisms of AA on SCI-induced ALI. One-hundred and fifty Sprague-Dawley rats were randomly assigned to five groups: sham, SCI, SCI + dexamethasone (Dex, 2 mg/kg), SCI + AA (30 mg/kg), and SCI + AA (75 mg/kg). The influences of AA on histologic changes, pulmonary edema, neutrophil infiltration and activation, proinflammatory cytokine production, oxidative stress, and Nrf2 and NLRP3 inflammasome protein expression were estimated...
December 2016: Inflammation
Oktay Gurcan, Ahmet Gurhan Gurcay, Atilla Kazanci, Salim Senturk, Ebru Bodur, Ebru Umay Karaca, Omer Faruk Turkoglu, Murat Bavbek
AIM: Spinal cord injury (SCI) is a devastating condition of the central nervous system. Today any therapeutic agent has not been proved to heal this complex condition yet. Asiatic acid (AA), which has been used in the far Eastern countries as an anti-inflammatory agent, antioxidant and wound healing therapeutic for years. We investigated efficiency of AA administration just after spinal cord injury in rats. MATERIAL AND METHODS: Adult male Sprague-Dawley rats ( n =32) were drafted in to Four experimental groups (Laminectomy, Laminectomy+ Trauma, Vehicle, AA) ramdomly...
October 2, 2015: Turkish Neurosurgery
Jae-Won Lee, Hyun Ah Park, Ok-Kyoung Kwon, Yin-Gi Jang, Ju Yeong Kim, Bo Kyung Choi, Hee Jae Lee, Sangwoo Lee, Jin-Hyub Paik, Sei-Ryang Oh, Kyung-Seop Ahn, Hyun-Jun Lee
Asiatic acid (AA) is one of the major components of Titrated extract of Centella asiatica (TECA), which has been reported to possess antioxidant and anti-inflammatory activities. The purpose of this study was to investigate the protective effect of AA on pulmonary inflammation induced by cigarette smoke (CS). AA significantly attenuated the infiltration of inflammatory cells in bronchoalveolar lavage fluid (BALF) of CS exposure mice. AA also decreased ROS production and NE activity, and inhibited the release of proinflammatory cytokines in BALF...
October 2016: International Immunopharmacology
Ishtdeep Kaur, Nancy Suthar, Jasmeen Kaur, Yogita Bansal, Gulshan Bansal
Regulatory guidelines recommend systematic stability studies on a herbal product to establish its shelf life. In the present study, commercial extracts (Types I and II) and freshly prepared extract (Type III) of Centella asiatica were subjected to accelerated stability testing for 6 months. Control and stability samples were evaluated for organoleptics, pH, moisture, total phenolic content (TPC), asiatic acid, kaempherol, and high-performance thin layer chromatography fingerprints, and for antioxidant and acetylcholinesterase inhibitory activities...
October 2016: Journal of Evidence-based Complementary & Alternative Medicine
Hui Jiang, Guoshuai Zheng, Junwei Lv, Heyu Chen, Jinjin Lin, Yiyang Li, Guorong Fan, Xianting Ding
Centella asiatica, commonly known as Gotu kola, has been widely used as a traditional herb for decades. Yet, the study on which compounds or compound combinations actually lead to its brain benefits remains scarce. To study the neuroprotection effects of Centella asiatica, neuronal differentiation of PC12 cells was applied. In our pilot study, we isolated 45 Centella asiatica fractions and tested their abilities for inducing neuronal differentiation on PC12 cells. The most effective fraction showed robust induction in neurite outgrowth and neurofilament expression...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Sven Sommerwerk, Lucie Heller, Julia Kuhfs, René Csuk
2,3-Di-O-acetyl-triterpenoic acid derived amides possessing a (2β, 3β) configuration in ring A and two acetyl groups were previously shown to possess high cytotoxicity for human tumor cell lines but to exhibit low cytotoxicity for non-malignant mouse fibroblasts. In this study, augustic acid (1) and 2-epi-corosolic acid (2) were chosen as starting points for the synthesis of analogs. While augustic acid derived 3-quinolinyl amide 9 gave low EC50 values in SRB assays but was cytotoxic for all lines, the isomeric 4-isoquinolinyl amide 21 was very cytotoxic for the tumor cell lines but significantly less cytotoxic for the mouse fibroblasts NIH 3T3...
October 21, 2016: European Journal of Medicinal Chemistry
Zhiling Li, Xianzhong Xiao, Mingshi Yang
Asiatic acid (AA), a major triterpene isolated from Centella asiatica (L.) Urban, is known to exert various pharmacological activities, including anti-inflammatory and antioxidant effects. The aim of this study was to evaluate the anti-inflammatory effects of AA on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and clarify the underlying mechanisms. Lung pathological changes were assessed by H&E staining. The myeloperoxidase (MPO) activity was detected by MPO assay. The levels of inflammatory cytokines were measured by ELISA...
October 2016: Inflammation
Zhen-Guo Ma, Jia Dai, Wen-Ying Wei, Wen-Bin Zhang, Si-Chi Xu, Hai-Han Liao, Zheng Yang, Qi-Zhu Tang
BACKGROUND: AMPactivated protein kinase α (AMPKα) is closely involved in the process of cardiac hypertrophy. Asiatic acid (AA), a pentacyclic triterpene, was found to activate AMPKα in our preliminary experiment. However, its effects on the development of cardiac hypertrophy remain unclear. The present study was to determine whether AA could protect against cardiac hypertrophy. METHODS: Mice subjected to aortic banding were orally given AA (10 or 30mg/kg) for 7 weeks...
2016: International Journal of Biological Sciences
Somchai Sawatdee, Kanuengnit Choochuay, Wirot Chanthorn, Teerapol Srichana
Centella asiatica was extracted by methanol. The assay content of triterpenes in the extract was 0.12 % asiatic acid, 0.54 % madecassic acid, 0.25 % asiaticoside and 1.02 % madecassoside. The extract was complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) and formulated with Eudragit E100, glycerol, PEG 400, copovidone, ethanol and purified water. A clear yellowish solution (F1-F8) was obtained. The formulations had a pH of 5.5-6.0 with viscosity in the range of 20-60 mPa s, surface tension 20.3-24.6 mN m-1 and contact angle less than 20°...
June 1, 2016: Acta Pharmaceutica
Jariya Umka Welbat, Apiwat Sirichoat, Wunnee Chaijaroonkhanarak, Parichat Prachaney, Wanassanun Pannangrong, Poungrat Pakdeechote, Bungorn Sripanidkulchai, Peter Wigmore
Valproic acid (VPA) is commonly prescribed as an anticonvulsant and mood stabilizer used in the treatment of epilepsy and bipolar disorder. A recent study has demonstrated that VPA reduces histone deacetylase (HDAC) activity, an action which is believed to contribute to the effects of VPA on neural stem cell proliferation and differentiation which may explain the cognitive impairments produced in rodents and patients. Asiatic acid is a triterpenoid derived from the medicinal plant Centella asiatica. Our previous study has shown that Asiatic acid improves working spatial memory and increases cell proliferation in the sub granular zone of the hippocampal dentate gyrus...
2016: Nutrients
Wu Jiang, Maoqiang Li, Fan He, Zhenyu Bian, Qifang He, Xuepeng Wang, Wangxiang Yao, Liulong Zhu
AIMS: The present study investigated the therapeutic efficacy of asiatic acid (AA) on spinal cord injury (SCI) as well as the underlying mechanisms. MAIN METHODS: Sprague-Dawley rats (n=150) were randomly assigned to five groups: sham, SCI, SCI+methylprednisolone (30mg/kg), SCI+AA (30mg/kg), and SCI+AA (75mg/kg). Motor function, histological changes, neutrophil infiltration, proinflammatory cytokine production, and oxidative stress as well as nuclear factor erythroid 2-related factor (Nrf)2, heme oxygenase (HO)-1, and nucleotide-binding domain-like receptor protein (NLRP)3 levels were evaluated...
July 15, 2016: Life Sciences
Putcharawipa Maneesai, Sarawoot Bunbupha, Upa Kukongviriyapan, Parichat Prachaney, Panot Tangsucharit, Veerapol Kukongviriyapan, Poungrat Pakdeechote
BACKGROUND: In the rat model of high carbohydrate, high fat (HCHF) diet-induced metabolic syndrome (MS), previous studies have found that asiatic acid has an antihypertensive effect. In this study, we investigated effects of asiatic acid on vascular structure, vascular function and renin-angiotensin system (RAS) in HCHF diet-induced MS rats. METHODS: Male Sprague-Dawley rats were divided into three treatment groups for the 15 week study: a control group fed a normal diet, a MS group fed HCHF diet plus 15 % fructose in their drinking water for 15 weeks, and an asiatic acid treated group that received a HCHF diet plus fructose for 15 weeks and also received orally administered asiatic acid (20 mg/kg BW/day) for the final 3 weeks...
2016: BMC Complementary and Alternative Medicine
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