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metamizol anastomosis

Heiko Neuss, Wieland Raue, Verena Müller, Wilko Weichert, Wolfgang Schwenk, Julian W Mall
PURPOSE: We performed an experimental study in a rabbit model to investigate the effects of a selective Cox-2 inhibitor (Valdecoxib) on anastomotic healing following large bowel resection after 1 week. MATERIALS AND METHODS: Eighty New Zealand white rabbits were randomized into four groups and underwent a colon resection with end-to-end anastomosis. Group 1 (n = 20) was treated with Valdecoxib, group 2 with Metamizole (Novalgin), group 3 with Resveratrol (specific Cox-1 inhibitor), or a placebo vehicle with similar volume (group 4)...
May 2009: International Journal of Colorectal Disease
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