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https://www.readbyqxmd.com/read/29147567/leriche-syndrome-the-inferior-mesenteric-artery-saves-the-lower-extremity
#1
Mahmoud Assaad, Sunit Tolia, Marcel Zughaib
Leriche syndrome presents as a triad of claudication, erectile dysfunction, and decreased distal pulses. This syndrome is a well-recognized entity in the current literature; however, our case report illustrates that even with a severe ostial lesion of the inferior mesenteric artery, the vessel was able to provide perfusion to bilateral lower extremities. The patient presented with symptoms of progressive pain in his right leg that limited his physical activity and he also complained of paresthesia, pallor, and cold skin with black discoloration of his toes bilaterally...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29144890/comprehensive-analysis-of-patients-with-neuromyelitis-optica-spectrum-disorder-nmosd-combined-with-chronic-hepatitis-b-chb-infection-and-seropositive-for-anti-aquaporin-4-antibody
#2
Jia Liu, Li Xu, Zhuo-Lin Chen, Min Li, Huan Yi, Fu-Hua Peng
Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody (AQP4-Ab). Demographic, clinical, laboratory, neuroimaging, outcome, and follow-up data of the 10 patients were retrospectively analyzed...
November 16, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29137102/lateral-medullary-infarction-with-similar-features-of-brown-sequard-syndrome-caused-by-vertebrobasilar-dysplasia-and-klippel-feil-syndrome-a-case-report
#3
Jingzhe Han, Duanhua Cao, Guomei Ma, Tingting Wang, Ye Ji, Zhilei Kang
RATIONALE: Patients with Klippel-Feil syndrome (KFS) are always anomaly associated with vertebrobasilar dysplasia. That may present commonly as infarction of brainstem, medulla, and cerebellum. In this article, we reported a rare case of lateral medullary infarction (LMI) with similar features of Brown Sequard syndrome caused by vertebrobasilar dysplasia and KFS, and the 2 rare conditions that are causally related. The case is being reported because of its unusual and rare presentation...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135884/prognostic-factors-and-treatment-of-spinal-astrocytomas-a-multi-institutional-cohort-analysis
#4
Yingjie Zou, James Sun, Yangying Zhou, Harrison Xiao Bai, Xiangyan Huang, Ranjith Babu, Alessandro Landi, Kap Sum Foong, Zishu Zhang, John Woo, Yongguang Tao, Xuejun Li, Xiangqi Tang, Bo Xiao, Paul Zhang, Li Yang
STUDY DESIGN: Retrospective cohort analysis of patients with spinal astrocytoma from multi-institutional data and the literature. OBJECTIVE: To determine the prognostic factors, treatment, and survival of patients. SUMMARY OF BACKGROUND DATA: Our current understanding of the epidemiology, prognosis and optimal treatment of spinal astrocytoma is limited. The literature is confined to case reports or small institutional case series. METHOD: Patient demographics, tumor characteristics, treatments, and outcomes were extracted...
November 10, 2017: Spine
https://www.readbyqxmd.com/read/29126848/evaluation-of-external-vibratory-stimulation-as-a-treatment-for-chronic-scrotal-pain-in-adult-men-a-single-center-open-label-pilot-study
#5
Yash S Khandwala, Fernando Serrano, Michael L Eisenberg
BACKGROUND AND AIMS: Chronic scrotal pain is a common yet poorly understood urologic disease. Current treatment paradigms are sub-optimal and include anti-inflammatory drugs and opioids as well as invasive surgical management such as microdenervation of the spermatic cord. In this study, the efficacy of external vibratory stimulation (EVS) was evaluated as an alternative treatment option for idiopathic scrotal pain. MATERIALS AND METHODS: Ten consecutive patients presenting to an academic urology clinic between December 2016 and April 2017 with scrotal pain were prospectively enrolled...
November 7, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29124490/nerve-blocks-in-pediatric-and-adolescent-headache-disorders
#6
REVIEW
Alexander Sasha Dubrovsky
PURPOSE OF REVIEW: Peripheral nerve blocks of the scalp, mainly greater occipital nerve blocks, have received a renewed interest amongst pediatric providers as they offer an alternate option to provide both acute and chronic relief from the suffering of children with difficult to treat headaches. This narrative review will provide an in-depth discussion of the published pediatric-specific studies exploring the utility of nerve blocks for pediatric headache disorders. RECENT FINDINGS: A total of seven pediatric publications have been reported to date and reveal excellent therapeutic effectiveness of bilateral greater occipital nerve blocks on primary chronic headaches and post-traumatic headaches...
November 9, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29105244/spinal-cord-stimulation-for-treating-chronic-pain-reviewing-preclinical-and-clinical-data-on-paresthesia-free-high-frequency-therapy
#7
REVIEW
Krishnan Chakravarthy, Hira Richter, Paul J Christo, Kayode Williams, Yun Guan
BACKGROUND: Traditional spinal cord stimulation (SCS) requires that paresthesia overlaps chronic painful areas. However, the new paradigm high-frequency SCS (HF-SCS) does not rely on paresthesia. STUDY DESIGN: A review of preclinical and clinical studies regarding the use of paresthesia-free HF-SCS for various chronic pain states. METHODS: We reviewed available literatures on HF-SCS, including Nevro's paresthesia-free ultra high-frequency 10 kHz therapy (HF10-SCS)...
November 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29093364/mercury-poisoning-in-a-fisherman-working-on-a-pelagic-fishing-vessel-due-to-excessive-tuna-consumption
#8
Ji-Sung Ahn, Kyung Wook Kang, Won-Yang Kang, Hyeong-Min Lim, Seunghyeon Cho, Jai-Dong Moon, Won-Ju Park
OBJECTIVE: To report the case of a fisherman who developed chronic mercury poisoning due to excessive consumption of tuna while working on a pelagic fishing vessel. CASE REPORT: A 48-year-old male deep-sea fisherman developed paresthesia and pain in both legs while working at sea. He continued working for over 4 months on a pelagic fishing vessel but was eventually unable to function normally as his condition deteriorated. Upon arrival on land, he received specialist treatment, including imaging studies, for 2 months; however, the cause of the symptoms was not identified...
November 1, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29084313/safety-and-efficacy-of-focused-ultrasound-thalamotomy-for-patients-with-medication-refractory-tremor-dominant-parkinson-disease-a-randomized-clinical-trial
#9
Aaron E Bond, Binit B Shah, Diane S Huss, Robert F Dallapiazza, Amy Warren, Madaline B Harrison, Scott A Sperling, Xin-Qun Wang, Ryder Gwinn, Jennie Witt, Susie Ro, W Jeffrey Elias
Importance: Clinical trials have confirmed the efficacy of focused ultrasound (FUS) thalamotomy in essential tremor, but its effectiveness and safety for managing tremor-dominant Parkinson disease (TDPD) is unknown. Objective: To assess safety and efficacy at 12-month follow-up, accounting for placebo response, of unilateral FUS thalamotomy for patients with TDPD. Design, Setting, and Participants: Of the 326 patients identified from an in-house database, 53 patients consented to be screened...
October 30, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29083363/a-pseudotumoral-lesion-diagnosed-for-a-hypertrofic-fibrosis-at-the-proximal-stump-in-anterior-tibialis-tendon-missed-rupture-a-case-report
#10
Elena M Samaila, Filippo Luiso, Giacomo Trivellin, Matteo Brunelli, Bruno Magnan
The Anterior Tibialis is the most important muscle in ankle dorsiflexion. The anterior tibialis tendon (ATT)'s rupture is an infrequent condition which can be both traumatic and spontaneous. Clinic is poor and it is necessary to confirm the suspect by US or MRI. The reported case refers to a 40 years old man who had a direct trauma at ankle and midfoot which was originally conservatively treated for an ankle sprain. Three months later he returned with pain, swelling and paresthesia. MRI was performed showing a neoformation in the contest of ATT's rupture...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29075542/multiple-sclerosis-presenting-with-facial-twitching-myokymia-and-hemifacial-spasms
#11
Risha Hertz, James Espinosa, Alan Lucerna, Doug Stranges
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The etiology is insufficiently understood. Autoimmune, genetic, viral, and environmental factors have been hypothesized. MS is twice as common in women as in men between the ages of 20 and 50 years. There is no known cure for MS. Current medical treatment helps to prevent new attacks and improve function after an attack. MS is diagnosed by physical examination, diagnostic imaging, and examination of cerebral spinal fluid...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29075099/design-and-evaluation-of-lidocaine-and-prilocaine-coloaded-nanoparticulate-drug-delivery-systems-for-topical-anesthetic-analgesic-therapy-a-comparison-between-solid-lipid-nanoparticles-and-nanostructured-lipid-carriers
#12
Peijun You, Ran Yuan, Chuanyu Chen
PURPOSE: Topical anesthesia analgesic therapy has diverse applicability in solving the barrier properties of skin and unfavorable physicochemical properties of drugs. Lidocaine (LID) combined with prilocaine (PRI) has been used as a topical preparation for dermal anesthesia for treatment of conditions such as paresthesia. MATERIALS AND METHODS: In this study, for combination anesthesia and overcoming the drawbacks of LID and PRI, respectively, LID- and PRI-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were prepared and characterized by determination of their particle size, drug loading capacity, stability, in vitro drug release behavior and in vitro cellular viability...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29075055/single-dose-preemptive-plerixafor-for-stem-cell-mobilization-for-asct-after-lenalidomide-based-therapy-in-multiple-myeloma-impact-in-resource-limited-setting
#13
Rajiv Kumar, Rajan Kapoor, Bhushan Asthana, Jasjit Singh, Tarun Verma, Rajesh Chilaka, N K Singh, Ajay Sharma, S Das, Velu Nair
Peripheral blood stem cell mobilization with cytokines for autologous stem cell transplant in multiple myeloma is adversely affected by initial induction therapy consisting of either Lenalidomide or cytotoxic drugs, with failure rates of up to 45%. The use of Plerixafor with G-CSF for PBSC mobilisation significantly improves the chances of a successful mobilization. Plerixafor is a costly therapy and increases the overall costs of ASCT which can affect the number of patients being taken up for ASCT in resource limited settings...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29070967/case-report-glatiramer-acetate-induced-serum-sickness
#14
Paul Ferguson
Multiple sclerosis (MS) is a central nervous system demyelinating disease with a prevalence of approximately 400,000 individuals in the United States. Glatiramer acetate is a frequently prescribed disease-modifying therapy used for the management of relapsing forms of the disease. A 40-year-old woman with relapsing-remitting MS presented with symptomatic concerns of vomiting, fever, diffuse rash, joint and low back pain, and distal lower-limb paresthesia and was subsequently admitted to the hospital for investigation and treatment...
September 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/29067960/relationship-between-apolipoprotein-superfamily-and-parkinson-s-disease
#15
REVIEW
Lin Li, Ming-Su Liu, Guang-Qin Li, Jie Tang, Yan Liao, Yang Zheng, Tong-Li Guo, Xin Kang, Mao-Ting Yuan
OBJECTIVE: Parkinson's disease (PD) is featured with motor disorder and nonmotor manifestations including psychological symptoms, autonomic nervous system dysfunction, and paresthesia, which results in great inconvenience to the patients' life. The apolipoprotein (Apo) superfamily, as a group of potentially modifiable biomarkers in clinical practice, is of increasing significance in the diagnosis, evaluation, and prognosis of PD. The present review summarized the current understanding and emerging findings of the relationship between Apo superfamily and PD...
November 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29067271/development-of-a-youth-report-measure-of-dpn-symptoms-conceptualization-and-content-validation
#16
Joanne Moser, Terri Lipman, David R Langdon, Katherine B Bevans
AIMS: To develop a content valid youth-report measure of diabetic peripheral neuropathy (DPN) symptoms. METHODS: Semi-structured interviews with 5 clinicians and 15 youth aged 8-17 with diabetes were conducted to elicit and clarify youth's DPN experiences. A systematic review of existing adult-report DPN symptom measures was conducted to identify item concepts representative of each experience. The concepts were transformed into items that were iteratively revised based on cognitive interviews (n = 13 youth aged 8-17) and readability analyses...
September 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29067145/electroacupuncture-therapy-for-auricular-paresthesia
#17
Masaya Fukushima, Hinata Sakuraba, Nobuko Shiraiwa, Shonosuke Matsushita
Background: The great auricular nerve (GAN) provides sensory innervation to the skin around the auricle. Although disorder of this nerve has been reported, great auricular neuralgia, as reported by Blumenthal in 1992, is uncommon. The authors report a case of auricular paresthesia that responded well to electroacupuncture treatment (EAT). Case: A man in his 60s was consulted in the clinic after a 6-month history of experiencing tingling sensations of the skin around the auricle. General degenerative deformity of the cervical spine was observed using computed radiography scans and magnetic resonance imaging; tactile hyperesthesia in the skin of the GAN area was also noted...
October 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/29067139/influence-of-electroacupuncture-and-laser-acupuncture-on-treating-paresthesia-in-patients-submitted-to-combined-orthognathic-surgery-and-genioplasty
#18
Renata F de Oliveira, Ricardo S Goldman, Fausto Medeiros Mendes, Patricia Moreira de Freitas
Objective: The goal of this research was to observe the influence of electroacupuncture (EA) and laser-acupuncture on the return of tactile/pain sensitivity in patients who underwent orthognathic surgery. Materials and Methods: Thirty volunteers subjected to orthognathic surgery were evaluated and randomly divided into 2 groups, in which 3 treatments were evaluated: control (n = 30) (G0, medication + placebo laser treatment) and 2 experimental treatments (n = 15) (G1, medication + EA) or G2 (medication + laser-acupuncture)...
October 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/29066932/efficiency-of-spinal-anesthesia-versus-general-anesthesia-for-lumbar-spinal-surgery-a-retrospective-analysis-of-544-patients
#19
John T Pierce, Guy Kositratna, Mark A Attiah, Michael J Kallan, Rebecca Koenigsberg, Peter Syre, David Wyler, Paul J Marcotte, W Andrew Kofke, William C Welch
BACKGROUND: Previous studies have shown varying results in selected outcomes when directly comparing spinal anesthesia to general in lumbar surgery. Some studies have shown reduced surgical time, postoperative pain, time in the postanesthesia care unit (PACU), incidence of urinary retention, postoperative nausea, and more favorable cost-effectiveness with spinal anesthesia. Despite these results, the current literature has also shown contradictory results in between-group comparisons...
2017: Local and Regional Anesthesia
https://www.readbyqxmd.com/read/29061242/neurologic-manifestations-of-rheumatoid-arthritis
#20
REVIEW
Kimberly DeQuattro, John B Imboden
Neurologic manifestations of rheumatoid arthritis (RA) range in severity from mild paresthesias in the hand from carpal tunnel syndrome to sudden death due to impingement of the medulla by an eroded, vertically subluxed dens. Most neurologic complications are a consequence of articular inflammation and damage that leads to compression of adjacent structures of the central or peripheral nervous systems. Rare but serious extra-articular manifestations include inflammation of the meninges and ischemic neuropathies due to necrotizing arteritis of the vasa vasorum...
November 2017: Rheumatic Diseases Clinics of North America
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