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https://www.readbyqxmd.com/read/29457665/comparative-analysis-of-lipid-mediated-crispr-cas9-genome-editing-techniques
#1
Kelsey P Ringer, Mark G Roth, Mitchell S Garey, Ted B Piorczynski, Arminda Suli, Jason M Hansen, Jonathan K Alder
CRISPR-Cas technology has revolutionized genome engineering. While Cas9 was not the first programmable endonuclease identified, its simplicity of use has driven widespread adoption in a short period of time. While CRISPR-Cas genome editing holds enormous potential for clinical applications, its use in laboratory settings for genotype-phenotype studies and genome-wide screens has led to breakthroughs in the understanding of many molecular pathways. Numerous protocols have been described for introducing CRISPR-Cas components into cells, and here we sought to simplify and optimize a protocol for genome editing using readily available and inexpensive tools...
February 19, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29457418/-outcomes-and-complications-of-tightrope-button-plate-for-repairing-acromioclavicular-dislocation
#2
Yong-Xiang Zuo, Zi-Ping Ma
OBJECTIVE: To study the clinical outcome and complications of Tightrope button plate for repairing acromioclavicular dislocation of Rockwood type III to V. METHODS: From May 2014 to December 2016, 17 patients with acromioclavicular dislocation of type III-V were treated with Tightrope button plate including 10 males and 7 females with an average age 39.8 years old ranging from 20 to 68 years old. Four patients were treated with arthroscopy and 17 patients were treated with mini-invasive by X-ray assisted...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457404/-perioperative-and-drug-management-of-patients-with-rheumatoid-arthritis-treated-with-joint-replacement
#3
REVIEW
Jun Liu, Ping Zhen, Sheng-Hu Zhou, Qi Tian, Hui Chen, Jie Shi, Wei Wang, Xiao-le He, Xu-Sheng Li
Rheumatoid arthritis (RA) is a most common inflammatory joint disease with direct invasion of joint synovial membrane, cartilage and bone. Currently, although the RA mitigation drugs are being improved continously, but these drugs only can delay the development of joint dysfunction. Total hip arthroplasty or total knee arthroplasty(THA or TKA) has become the only choices for patients with advanced RA, and the joint function and deformity of the patients after surgical treatment can be improved to some extent...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29456900/a-barium-swallow-study-leading-to-an-incidental-finding-on-a-screening-colonoscopy
#4
Patricia Guzman Rojas, Chirin Orabi, Glenn Speth
Barolith is a mixture of firm feces with barium sulfate, and a frequent cause of obstruction of the appendiceal lumen that can result in appendicitis. Nonetheless, some other complications like aspiration, allergic reaction, and bowel obstruction have also been reported. We present the case of a 71-year-old man with a history of amyotrophic lateral sclerosis (ALS), who came to the gastroenterology clinic complaining of intermittent loose stools and dysphagia to solids for the past months. The patient underwent a barium swallow study six days prior and was completely normal...
December 7, 2017: Curēus
https://www.readbyqxmd.com/read/29456873/the-rockefeller-university-clinical-scholars-kl2-program-2006-2016
#5
Sarah J Schlesinger, Michelle Romanick, Jonathan N Tobin, Donna Brassil, Rhonda G Kost, Rita Devine, Barbara O'Sullivan, Roger D Vaughan, Yupu Liang, Joel Correa da Rosa, Maija Williams, James G Krueger, Barry S Coller
Introduction and Methods: The Rockefeller Clinical Scholars (KL2) Program began in 1976 and transitioned into a 3-year Master's degree program in 2006 when Rockefeller joined the NIH Clinical and Translational Science Award (CTSA) program. The program consists of ~15 trainees supported by the CTSA KL2 award and University funds. It is designed to provide an optimal environment for junior translational investigators to develop team science and leadership skills by designing and performing a human subjects protocol under the supervision of a distinguished senior investigator mentor and a team of content expert educators...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29456862/thin-laryngeal-foreign-bodies-in-infants-diagnostic-potential-of-mdct
#6
Antonella Concerto, Marco Cavallaro, Carmela Visalli, Anna Maria Bagnato, Ugo Barbaro, Ignazio Salamone
A laryngeal foreign body (FB) is a significant, life-threatening event in the paediatric population. Incomplete airways obstruction by a thin, laminar, radiolucent FB lodged in the glottis or supraglottis is a rare occurrence that may present with non-specific symptoms, absence of chest findings, and normal radiographic investigations, resulting in misdiagnosis, delay in diagnosis, or prolonged recovery. We report two cases of 10-month-old male infants, each with a thin radiolucent FB lodged between the vocal folds that was detected with low-dose multidetector computed tomography (MDCT) and thin-slice reconstruction...
April 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29456774/gastric-aspiration-and-its-role-in-airway-inflammation
#7
REVIEW
E B Hunt, A Sullivan, J Galvin, J MacSharry, D M Murphy
Gastro-Oesophageal Reflux (GOR) has been associated with chronic airway diseases while the passage of foreign matter into airways and lungs through aspiration has the potential to initiate a wide spectrum of pulmonary disorders. The clinical syndrome resulting from such aspiration will depend both on the quantity and nature of the aspirate as well as the individual host response. Aspiration of gastric fluids may cause damage to airway epithelium, not only because acidity is toxic to bronchial epithelial cells but also due to the effect of digestive enzymes such as pepsin and bile salts...
2018: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/29455709/what-do-they-know-guidelines-and-knowledge-translation-for-foreign-health-sector-workers-following-natural-disasters
#8
Ola Dunin-Bell
Introduction The incidence of natural disasters is increasing worldwide, with countries the least well-equipped to mitigate or manage them suffering the greatest losses. Following natural disasters, ill-prepared foreign responders may become a burden to the affected population, or cause harm to those needing help. Problem The study was performed to determine if international guidelines for foreign workers in the health sector exist, and evidence of their implementation. METHODS: A structured literature search was used to identify guidelines for foreign health workers (FHWs) responding to natural disasters...
February 19, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29455577/exploring-autophagy-with-gene-ontology
#9
Paul Denny, Marc Feuermann, David P Hill, Ruth C Lovering, Helene Plun-Favreau, Paola Roncaglia
Autophagy is a fundamental cellular process that is well conserved among eukaryotes. It is one of the strategies that cells use to catabolize substances in a controlled way. Autophagy is used for recycling cellular components, responding to cellular stresses and ridding cells of foreign material. Perturbations in autophagy have been implicated in a number of pathological conditions such as neurodegeneration, cardiac disease and cancer. The growing knowledge about autophagic mechanisms needs to be collected in a computable and shareable format to allow its use in data representation and interpretation...
February 17, 2018: Autophagy
https://www.readbyqxmd.com/read/29455525/graphene-oxide-decorated-with-cerium-iv-oxide-in-determination-of-ultra-trace-metal-ions-and-speciation-of-selenium
#10
Anna Baranik, Rafal Sitko, Anna Gagor, Ignasi Queralt, Eva Margui, Beata Zawisza
Graphene oxide decorated with cerium (IV) oxide (GO/CeO2) was synthesized and applied in adsorption of several metal ions such as As(III), As(V), Se(IV), Cu(II) and Pb(II) from aqueous samples. The important feature of GO/CeO2 nanocomposite is also its selectivity towards selenite in the presence of selenate. The structure of GO/CeO2 has been proven by microscopic and spectroscopic techniques. The maximum adsorption capacities of GO/CeO2 calculated by Langmuir model towards arsenic, selenium, copper and lead ions are between 6 and 30 mg g-1...
February 18, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29455151/nutrient-management-via-struvite-precipitation-and-recovery-from-various-agroindustrial-wastewaters-process-feasibility-and-struvite-quality
#11
Raffaele Taddeo, Mari Honkanen, Kari Kolppo, Raghida Lepistö
Improving environmental protection and finding sustainable and renewable resources of nutrients are core issues in circular bioeconomy. Thus, this study evaluated the efficiency of recovering struvite, MgNH4 PO4 ·6H2 O, from different agro-industrial wastewaters (four highly loaded reject waters of anaerobically co-digested agro-industrial waste and a raw swine slurry) and assessed the quality of recovered struvite crystals and their reusability as fertilizer. The efficiency of crystallization (Ec 40-80%) and amount of struvite in the precipitate (Pp 55-94%) highly varied due to the characteristics of influent wastewaters, particularly to the content of competing elements, such as alkaline and heavy metals and total solids (TS)...
February 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29454741/exploiting-or-overcoming-the-dome-trap-for-enhanced-oral-immunization-and-drug-delivery
#12
REVIEW
Jianping Qi, Jie Zhuang, Yongjiu Lv, Yi Lu, Wei Wu
The microfold cells (M cells) residing in the outmost follicle-associated epithelia (FAE) of Peyer's patches capture foreign particles and hand over to sub-FAE lymphatics, where the particles are retained and disposed subsequently. A concept of "dome trap" is proposed to highlight the significance of this mechanism. For oral immunization, it is better to exploit the entrapment capacity to maximize immune response, whereas for drug delivery it is better to overcome the dome trap to transport drugs into the systemic circulation...
February 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29454654/invasive-pulmonary-aspergillosis-and-influenza-co-infection-in-immunocompetent-hosts-case-reports-and-review-of-the-literature
#13
Melisa M Shah, Eric I Hsiao, Carl M Kirsch, Amit Gohil, Supriya Narasimhan, David A Stevens
Invasive pulmonary aspergillosis (IPA) is classically considered an illness of severely immunocompromised patients with limited host defenses. However, IPA has been reported in immunocompetent but critically ill patients. This report describes two fatal cases of pathologically confirmed IPA in patients with influenza in the intensive care unit. One patient had influenza B infection, whereas the other had influenza A H1N1. Both patients died despite broad-spectrum antimicrobials, mechanical ventilation, and vasopressor support...
February 2, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29453946/the-sexual-and-reproductive-health-of-foreign-born-women-in-the-united-states
#14
Athena Tapales, Ayana Douglas-Hall, Hannah Whitehead
OBJECTIVE: To explore the sexual and reproductive health (SRH) behaviors, health insurance coverage, and use of SRH services of women in the United States (U.S.) by nativity, disaggregated by race and ethnicity. STUDY DESIGN: We analyzed publicly-available and restricted data from the National Survey of Family Growth to assess differences and similarities between foreign-born and U.S.-born women, both overall and within Hispanic, non-Hispanic (NH) white, NH black, and NH Asian groups...
February 14, 2018: Contraception
https://www.readbyqxmd.com/read/29453546/a-drosophila-model-to-decipher-the-toxicity-of-nanoparticles-taken-through-oral-routes
#15
S Aurosman Pappus, Monalisa Mishra
In recent era, nanoparticles (NPs) are widely used in food, medicine and body implants. Besides it's wide use being a foreign particle it may have some noxious effect on the body. To understand the mechanistic role of NPs toxicity, Drosophila appeared to be a superior model organism. Toxicity of several nanoparticles were accessed using Drosophila. The NPs, after oral route of exposure enter into the gut, crosses the barrier of peritrophic membrane and induces apoptosis. The toxicity of NPs within gut resulted in developmental delay, with decrease in pupa count, fly hatching along with weight loss...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453486/immune-system-and-kidney-transplantation
#16
Badri Man Shrestha
The immune system recognises a transplanted kidney as foreign body and mounts immune response through cellular and humoral mechanisms leading to acute or chronic rejection, which ultimately results in graft loss. Over the last five decades, there have been significant advances in the understanding of the immune responses to transplanted organs in both experimental and clinical transplant settings. Modulation of the immune response by using immunosuppressive agents has led to successful outcomes after kidney transplantation...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29453201/hypercalcemia-associated-with-cosmetic-injections-a-systematic-review
#17
Niranjan Tachamo, Anthony Donato, Bidhya Timilsina, Salik Nazir, Saroj Lohani, Rashmi Dhital, Sijan Basnet
Cosmetic injections with silicone and polymethylmethacrylate are not FDA-approved for augmentation of body parts such as breast, buttock or legs, but they have been widely used for decades. Cosmetic injections can cause foreign body granulomas and occasionally severe and life-threatening hypercalcemia. We aimed to systematically analyze the published literature on cosmetic injection-associated hypercalcemia. Methods We searched relevant articles on hypercalcemia associated with various cosmetic injections and extracted relevant data on demographics, cosmetic injections used, severity of hypercalcemia, management and outcomes...
February 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29452992/activity-of-ceftobiprole-against-staphylococcus-spec-isolates-derived-from-foreign-body-associated-infections
#18
Gunnar T R Hischebeth, Sascha Gravius, Ernst Molitor, Hendrik Kohlhof, Achim Hoerauf, Caecilia Hilgers, Thomas M Randau
Antibiotic therapy is essential in foreign body associated infections. The treatment regime should aim at high tissue concentrations, high bioavailability, high biofilm penetration and good tolerance. We investigated whether the new cephalosporin ceftobiprole is active against clinical isolates from musculoskeletal foreign body associated infections. One hundred ninety-six staphylococci isolates (coagulase negative staphylococci and Staphylococcus aureus) derived from foreign body associated infections were tested towards susceptibility to ceftobiprole, using a test strip assay and broth microdilution...
January 31, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29452898/transcriptional-and-epigenetic-regulation-of-innate-like-t-lymphocyte-development
#19
REVIEW
Mihalis Verykokakis, Barbara L Kee
Invariant Natural Killer T (iNKT) cells are a heterogeneous innate T cell population that recognizes lipid antigens. Despite the monospecific nature of their T cell receptor, iNKT cells differentiate into stable sublineages during thymic development, before foreign antigen encounter. How iNKT cell subsets acquire and maintain their functional programs is a central question in innate lymphocyte biology. Global transcriptional and epigenetic profiling of iNKT subsets has provided insights into the internal wiring of these subsets that defines their identity...
February 13, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29451106/thinking-in-a-foreign-language-reduces-the-causality-bias
#20
Marcos Díaz-Lago, Helena Matute
The purpose of this research is to investigate the impact of a foreign language on the causality bias (i.e., the illusion that two events are causally related when they are not). We predict that using a foreign language could reduce the illusions of causality. A total of 36 native English speakers participated in Experiment 1, 80 native Spanish speakers in Experiment 2. They performed a standard contingency learning task, which can be used to detect causal illusions. Participants who performed the task in their native tongue replicated the illusion of causality effect, whereas those performing the task in their foreign language were more accurate in detecting that the two events were causally unrelated...
February 1, 2018: Quarterly Journal of Experimental Psychology: QJEP
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