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https://www.readbyqxmd.com/read/28340493/conservative-treatment-with-octreotide-to-provide-early-recovery-of-children-with-esophageal-perforation
#1
Ramazan Karabulut, Zafer Turkyilmaz, Kaan Sonmez, Abdullah Can Basaklar
Background The effectiveness of nonoperative treatment of esophageal perforation (EP) in children with octreotide is highlighted. Methods Records of nine patients (seven boys and two girls with an average age of 5.83 ± 5.35 years) with EP were reviewed. Results EP developed in six patients during dilation of esophageal stenosis (five of six caused by caustic burns). In the other three patients, EP developed after nasogastric placement, after endotracheal intubation, and during endoscopy for foreign body...
March 24, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28340410/development-of-fusogenic-glass-surfaces-that-impart-spatiotemporal-control-over-macrophage-fusion-direct-visualization-of-multinucleated-giant-cell-formation
#2
James J Faust, Wayne Christenson, Kyle Doudrick, Robert Ros, Tatiana P Ugarova
Implantation of synthetic material, including vascular grafts, pacemakers, etc. results in the foreign body reaction and the formation of multinucleated giant cells (MGCs) at the exterior surface of the implant. Despite the long-standing premise that fusion of mononucleated macrophages results in the formation of MGCs, to date, no published study has shown fusion in context with living specimens. This is due to the fact that optical-quality glass, which is required for the majority of live imaging techniques, does not promote macrophage fusion...
March 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28340358/lysosomal-rupture-induced-by-structurally-distinct-chitosans-either-promotes-a-type-1-ifn-response-or-activates-the-inflammasome-in-macrophages
#3
David Fong, Pascal Grégoire-Gélinas, Alexandre P Cheng, Tal Mezheritsky, Marc Lavertu, Sachiko Sato, Caroline D Hoemann
Chitosan is a family of glucosamine and N-acetyl glucosamine polysaccharides with poorly understood immune modulating properties. Here, functional U937 macrophage responses were analyzed in response to a novel library of twenty chitosans with controlled degree of deacetylation (DDA, 60-98%), molecular weight (1 to >100 kDa), and acetylation pattern (block vs. random). Specific chitosan preparations (10 or 190 kDa 80% block DDA and 3, 5, or 10 kDa 98% DDA) either induced macrophages to release CXCL10 and IL-1ra at 5-50 μg/mL, or activated the inflammasome to release IL-1β and PGE2 at 50-150 μg/mL...
March 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28340350/a-viral-immunoevasin-controls-innate-immunity-by-targeting-the-prototypical-natural-killer-cell-receptor-family
#4
Oscar A Aguilar, Richard Berry, Mir Munir A Rahim, Johanna J Reichel, Branka Popović, Miho Tanaka, Zhihui Fu, Gautham R Balaji, Timothy N H Lau, Megan M Tu, Christina L Kirkham, Ahmad Bakur Mahmoud, Aruz Mesci, Astrid Krmpotić, David S J Allan, Andrew P Makrigiannis, Stipan Jonjić, Jamie Rossjohn, James R Carlyle
Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ligand for the inhibitory and activating NKR-P1 (NK1.1) receptors. This murine cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector function by directly engaging the inhibitory NKR-P1B receptor...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28340349/structure-reveals-mechanisms-of-viral-suppressors-that-intercept-a-crispr-rna-guided-surveillance-complex
#5
Saikat Chowdhury, Joshua Carter, MaryClare F Rollins, Sarah M Golden, Ryan N Jackson, Connor Hoffmann, Lyn'Al Nosaka, Joseph Bondy-Denomy, Karen L Maxwell, Alan R Davidson, Elizabeth R Fischer, Gabriel C Lander, Blake Wiedenheft
Genetic conflict between viruses and their hosts drives evolution and genetic innovation. Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infection, and viruses have evolved diverse anti-CRISPR (Acr) proteins that subvert these immune systems. The adaptive immune system in Pseudomonas aeruginosa (type I-F) relies on a 350 kDa CRISPR RNA (crRNA)-guided surveillance complex (Csy complex) to bind foreign DNA and recruit a trans-acting nuclease for target degradation. Here, we report the cryo-electron microscopy (cryo-EM) structure of the Csy complex bound to two different Acr proteins, AcrF1 and AcrF2, at an average resolution of 3...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28339682/the-effects-of-interleukin-2-on-immune-response-regulation
#6
Ryan S Waters, Justin S A Perry, SunPil Han, Bibiana Bielekova, Tomas Gedeon
The immune system has many adaptive and dynamic components that are regulated to ensure appropriate, precise and rapid response to a foreign pathogen. A delayed or inadequate immune response can lead to prolonged disease, while an excessive or under-regulated response can lead to autoimmunity. The cytokine, interleukin-2 (IL-2) and its receptor IL-2R play an important role in maintaining this balance.The IL-2 receptor transduces pSTAT5 signal through both the intermediate and high affinity receptors, which differ from each other by the presence of CD25 chain in IL-2 receptor...
February 20, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28338580/textiloma-a-case-of-foreign-body-mimicking-a-spinal-tumor
#7
Ali Meshkini, Firooz Salehpour, Amir Rezakhah, Farhad Mirzaei, Mohammad KazemZadeh, Seyed Ahmad Naseri Alavi
STUDY DESIGN: Case report OBJECTIVE.: To report a case of foreign body mimicking spinal tumor Background: Textiloma, SUMMARY OF BACKGROUND DATA.: Gossypiboma or more broadly Retained Foreign Object (RFO) is a surgical complication resulting from foreign materials such as cotton or gauze pads, surgical sponge, accidentally left inside a patient's body. Such foreign materials cause foreign body reaction in the surrounding tissue. METHODS: A retrospective case report was performed...
March 23, 2017: Spine
https://www.readbyqxmd.com/read/28337694/the-posterior-fossa-and-foreign-accent-syndrome-report-of-two-new-cases-and-review-of-the-literature
#8
Stefanie Keulen, Peter Mariën, Kim van Dun, Roelien Bastiaanse, Mario Manto, Jo Verhoeven
Foreign accent syndrome is a rare motor speech disorder that causes patients to speak their language with a non-native accent. In the neurogenic condition, the disorder develops after lesions in the language dominant hemisphere, often affecting Broca's area, the insula, the supplementary motor area and the primary motor cortex. Here, we present two new cases of FAS after posterior fossa lesions. The first case is a 44-year-old, right-handed, Dutch-speaking man who suffered motor speech disturbances and a left hemiplegia after a pontine infarction...
March 23, 2017: Cerebellum
https://www.readbyqxmd.com/read/28337406/the-influence-of-health-concern-on-travel-plans-with-focus-on-the-zika-virus-in-2016
#9
Nicole J Olynk Widmar, S R Dominick, Audrey Ruple, Wallace E Tyner
Tourists consider many factors, including health, when choosing travel destinations. The potential for exposure to novel or foreign diseases alone can deter travelers from selecting high-risk locations for disease transmission. The 2015-2016 Zika Virus (ZIKV) outbreak in the Americas and Caribbean prompted the World Health Organization (WHO) to declare a Public Health Emergency of International Concern. This study investigated factors that may contribute to travel avoidance to areas experiencing ZIKV transmission while also considering different levels of health concern and awareness among groups with varying demographics...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28337347/myocardial-infarction-after-endoscopic-removal-of-foreign-body
#10
Carola Maraboto, Florentino Lupercio, Ileana L Piña
The development of cardiac complications during or after endoscopic procedures is rare. However, mortality from myocardial ischemia, particularly in the elderly population, is elevated. We illustrate the rare case of a 79-year-old man with multiple cardiovascular risk factors who developed a non-ST elevation myocardial infarction (NSTEMI) after endoscopic removal of a foreign body. This case report summarizes a rare complication of a low-risk procedure and highlights the importance of considering this potential adverse event, particularly in patients with significant cardiovascular risk factors, to promote early diagnosis and proper treatment...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28336743/is-socioeconomic-position-associated-with-risk-of-attempted-suicide-in-rural-sri-lanka-a-cross-sectional-study-of-165%C3%A2-000-individuals
#11
D W Knipe, D Gunnell, R Pieris, C Priyadarshana, M Weerasinghe, M Pearson, S Jayamanne, A H Dawson, F Mohamed, I Gawarammana, K Hawton, F Konradsen, M Eddleston, C Metcalfe
BACKGROUND: Lower socioeconomic position (SEP) is associated with an increased risk of suicidal behaviour in high-income countries, but this association is unclear in low-income and middle-income countries. METHODS: We investigated the association of SEP with attempted suicide in a cross-sectional survey of 165 233 Sri Lankans. SEP data were collected at the household (assets, social standing (highest occupation of a household member), foreign employment and young (≤40 years) female-headed households) and individual level (education and occupation)...
March 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28336382/migration-and-infectious-diseases
#12
REVIEW
Francesco Castelli, Giorgia Sulis
BACKGROUND: Infectious diseases still represent an important cause of morbidity and mortality among foreign-born individuals. The rising migration flows towards Europe throughout the last few years are raising renewed concerns about management issues and the potential associated risk for the native population. AIMS: To discuss the health implications and challenges related to the four phases of migration, from first arrival to stable resettlement. SOURCES: Scientific literature and relevant statistical reports...
March 20, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28336292/structural-elucidation-and-physiologic-functions-of-specialized-pro-resolving-mediators-and-their-receptors
#13
REVIEW
Nan Chiang, Charles N Serhan
The acute inflammatory response is host protective to contain foreign invaders. Many of today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious unwanted side effects such as immune suppression. Uncontrolled inflammation is now considered a pathophysiologic basis associated with, many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity and asthma, as well as the classic inflammatory diseases, e.g. arthritis, periodontal diseases...
March 20, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28335975/in-field-determination-of-trace-dissolved-manganese-in-estuarine-and-coastal-waters-with-automatic-on-line-preconcentration-and-flame-atomic-fluorescence-spectrometry
#14
Sichao Feng, Dongxing Yuan, Yongming Huang, Kunning Lin, Tingjin Zhou
An automatic on-line preconcentration and detection system for analysis of trace dissolved manganese (Mn) in estuarine and coastal waters was established, using preconcentration with IDA chelating resin and detection with flame atomic fluorescence spectrometer (FAFS). The rinse (pre-eluent) solution was optimized, for removing the interference ions while retaining the target element. It was found that the interference ions affected the chelating efficiency of Mn, causing variation of the detection blank and sensitivity...
April 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28335922/just-how-good-are-handheld-metal-detectors-for-ingested-foreign-bodies
#15
Jessica Mason, Alfred Sacchetti, Mel Herbert, Paul Jhun
No abstract text is available yet for this article.
April 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28335776/challenges-and-strategies-to-improve-the-availability-and-geographic-accessibility-of-physicians-in-portugal
#16
Ana Paula Cavalcante de Oliveira, Gilles Dussault, Isabel Craveiro
BACKGROUND: Shortages of physicians in remote, rural and other underserved areas and lack of general practitioners limit access to health services. The aims of this article are to identify the challenges faced by policy and decision-makers in Portugal to guarantee the availability and geographic accessibility to physicians in the National Health Service and to describe and analyse their causes, the strategies to tackle them and their results. We also raise the issue of whether research evidence was used or not in the process of policy development...
March 23, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28334680/assessing-driving-forces-of-land-use-and-land-cover-change-by-a-mixed-method-approach-in-north-eastern-ghana-west-africa
#17
Janina Kleemann, Gülendam Baysal, Henry N N Bulley, Christine Fürst
Land use and land cover change (LULCC) is the result of complex human-environmental interactions. The high interdependencies in social-ecological systems make it difficult to identify the main drivers. However, knowledge of key drivers of LULCC, including indirect (underlying) drivers which cannot be easily determined by spatial or economic analyses, is essential for land use planning and especially important in developing countries. We used a mixed-method approach in order to detect drivers of LULCC in the Upper East Region of northern Ghana by different qualitative and quantitative methods which were compared in a confidence level analysis...
March 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28334545/-conservative-treatment-of-late-aortic-graft-infection
#18
Peter Baľa, Kamil Zeman, Renata Kološová, Ivo Pavlas, Dušan Kučera
Aortic graft infection is one of the most serious complications of aortovascular surgery. Diagnosis is based on clini-cal and radiologic findings. The emphasis is put on early diagnosis and its impact on prognosis of patients. The management should be individualized. The gold standard is surgical treatment with complete excision of the infected foreign material with debridement of the surrounding tissue and repair of vascular continuity by extra-anatomic bypass or in situ bypass with autologous femoral vein or cryopreserved arterial allografts...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28334465/nurses-contribution-to-short-term-humanitarian-care-in-low-to-middle-income-countries-an-integrative-review-of-the-literature
#19
REVIEW
Sonja Dawson, Doug Elliott, Debra Jackson
AIM: To appraise the literature related to voluntary humanitarian work provided by international nurses in low to middle income countries (LMICs). BACKGROUND: Nurses and other health professionals are engaged with both governmental and non-governmental organisations to provide care within international humanitarian relief and development contexts. Current literature describes accounts of charitable health professional activity within short-term health focused humanitarian trips; however, there is minimal research describing the care that nurses provide and the professional roles and tasks they fulfil whilst participating in international volunteer health care service...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28333913/tuberculosis-among-foreign-born-persons-diagnosed-%C3%A2-10-years-after-arrival-in-the-united-states-2010-2015
#20
Clarisse A Tsang, Adam J Langer, Thomas R Navin, Lori R Armstrong
The majority of tuberculosis (TB) cases in the United States are attributable to reactivation of latent TB infection (LTBI) (1). LTBI refers to the condition when a person is infected with Mycobacterium tuberculosis without signs and symptoms, or radiographic or bacteriologic evidence of TB disease. CDC and the U.S. Preventive Services Task Force (USPSTF) recommend screening populations at increased risk for LTBI, including persons who have lived in congregate settings at high risk and persons who were born in, or are former residents of countries with TB incidence ≥20 cases per 100,000 population (2-4)...
March 24, 2017: MMWR. Morbidity and Mortality Weekly Report
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