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https://www.readbyqxmd.com/read/27915459/the-role-of-accompagnement-in-the-end-of-life-debate-in-france-from-solidarity-to-autonomy
#1
Marie Gaille, Ruth Horn
This article traces the way autonomy has become a recognised value in health care in France. In a country that based its social fundamentals on the very idea of solidarity for many years, autonomy has long been considered a foreign 'Anglo-American principle'. Taking the example of the end-of-life debate, the article shows, however, how the use of the French term 'accompagnement' allowed autonomy to be redefined and to be associated with the concept of solidarity. Exploring the arguments used over the past 25 years in professional guidelines, parliamentary reports, ethics committee reports, and legal texts, the authors describe the shift that took place in public and legal discourses on end-of-life care...
December 3, 2016: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/27914451/effects-of-fibroin-microcarriers-on-inflammation-and-regeneration-of-deep-skin-wounds-in-mice
#2
A Y Arkhipova, M A Nosenko, N V Malyuchenko, R V Zvartsev, A M Moisenovich, A S Zhdanova, T V Vasil'eva, E A Gorshkova, I I Agapov, M S Drutskaya, S A Nedospasov, M M Moisenovich
The process of tissue regeneration following damage takes place with direct participation of the immune system. The use of biomaterials as scaffolds to facilitate healing of skin wounds is a new and interesting area of regenerative medicine and biomedical research. In many ways, the regenerative potential of biological material is related to its ability to modulate the inflammatory response. At the same time, all foreign materials, once implanted into a living tissue, to varying degree cause an immune reaction...
November 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27914063/episweep-computationally-driven-reengineering-of-therapeutic-proteins-to-reduce-immunogenicity-while-maintaining-function
#3
Yoonjoo Choi, Deeptak Verma, Karl E Griswold, Chris Bailey-Kellogg
Therapeutic proteins are yielding ever more advanced and efficacious new drugs, but the biological origins of these highly effective therapeutics render them subject to immune surveillance within the patient's body. When recognized by the immune system as a foreign agent, protein drugs elicit a coordinated response that can manifest a range of clinical complications including rapid drug clearance, loss of functionality and efficacy, delayed infusion-like allergic reactions, more serious anaphylactic shock, and even induced auto-immunity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27913710/lessons-learned-from-35-cases-of-laryngeal-foreign-bodies-undergoing-misdiagnosis-in-pediatric-population
#4
Qingguo Chen, Hanqi Chu, Yanling Tao, Hongyan Huang, Liyan Peng
OBJECTIVES: To present 35 cases of laryngeal foreign bodies (FBs) in pediatric population undergoing misdiagnosis so as to draw on our lessons to improve early diagnosis. METHODS: A retrospective analysis over 15 years was conducted of 35 cases of laryngeal FBs undergoing misdiagnosis in children. Meanwhile, a control group, including 42 cases of laryngeal FBs without misdiagnosis in children, was set. These patients' clinical data were collected and analyzed to identify the risk factors for misdiagnosis...
December 2, 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27913297/phospholipase-c%C3%AE-1-suppresses-foreign-body-giant-cell-formation-by-maintaining-runx1-expression-in-macrophages
#5
Ye Seon Kim, Chang Youp Ok, Joon Seong Park, Ha Young Lee, Yoe-Sik Bae
Foreign body giant cell (FBGC) formation is associated with the inflammatory response following material implantation. However, the intracellular signaling events that regulate the process remain unclear. Here, we investigated the potential role of phospholipase C (PLC)γ1, a crucial enzyme required for growth factor-induced signaling, on FBGC formation. Knock-down of PLCγ1 using shRNA induced FBGC formation accompanied by increased expression of cathepsin K, DC-STAMP and CD36. Re-addition of PLCγ1 decreased FBGC formation...
November 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27912101/the-cytoskeleton-architecture-of-algivorous-protoplast-feeders-viridiraptoridae-rhizaria-indicates-actin-guided-perforation-of-prey-cell-walls
#6
Anna Busch, Sebastian Hess
Several distantly related, phagotrophic microeukaryotes share the remarkable ability to perforate foreign cell walls in a well-defined pattern to acquire protoplast material as food. The underlying cellular processes, especially the local application of cell wall degrading agents, are still unexplored. We examined the distribution of F-actin and alpha-tubulin in the algivorous, viridiraptorid amoeboflagellates Orciraptor agilis and Viridiraptor invadens over their life histories using phalloidin conjugates and immunolocalization...
October 31, 2016: Protist
https://www.readbyqxmd.com/read/27911466/transparent-nanofibrous-mesh-self-assembled-from-molecular-legos-for-high-efficiency-air-filtration-with-new-functionalities
#7
Varun Kumar Singh, Sai Kishore Ravi, Wanxin Sun, Swee Ching Tan
Alarming levels of particulate matter pollution in air pose a serious health threat in several countries, therefore intriguing a strong need for an economic and a viable technology of air filtration. Current air purification technology is rather expensive with certain types even having the risk of emitting hazardous by-products. The authors have developed a multifunctional air filter inspired from the nasal hairs possessing an ability to specifically trap/exhale the foreign particles and allergens while still letting the air flow...
December 2, 2016: Small
https://www.readbyqxmd.com/read/27910859/t-cell-programming-in-pancreatic-adenocarcinoma-a-review
#8
REVIEW
Y D Seo, V G Pillarisetty
Despite recent advancements in multimodal therapy, pancreatic ductal adenocarcinoma (PDA) continues to have a dismal prognosis. In the era of burgeoning immune therapies against previously difficult-to-treat malignancies, there has been growing interest in activating the immune system against PDA; however, unlike in other cancers such as melanoma and lymphoma, immunotherapy has not yielded many clinically significant results. To harness these mechanisms for therapeutic use, an in-depth understanding of T-cell programming in the immune microenvironment of PDA must be achieved...
December 2, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27910171/results-of-computed-tomography-in-dogs-with-suspected-wooden-foreign-bodies
#9
Christopher R Lamb, Elizabeth H W Pope, Karla C L Lee
Detection of wooden foreign bodies in dogs can be challenging. A retrospective, cross-sectional study was done to describe computed tomographic (CT) signs associated with wooden foreign bodies, and to estimate the accuracy of CT for detection of wooden foreign bodies. Patient records and CT images were reviewed for 72 dogs that had a history of suspected stick injury and CT of the affected body part, or possible wooden foreign object reported on CT, and had surgical exploration during the same period of hospitalization...
December 1, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27910006/william-d-hamilton-s-brazilian-lectures-and-his-unpublished-model-regarding-wynne-edwards-s-idea-of-natural-selection-with-a-note-on-pluralism-and-different-philosophical-approaches-to-evolution
#10
Emanuele Coco
In 1975, the English evolutionist William Donald Hamilton (1936-2000) held in Brazil a series of lectures entitled "Population genetics and social behaviour". The unpublished notes of these conferences-written by Hamilton and recently discovered at the British Library-offer an opportunity to reflect on some of the author's ideas about evolution. The year of the conference is particularly significant, as it took place shortly after the applications of the Price equation with which Hamilton was able to build a model that included several levels of selection...
December 2016: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/27909524/a-foreign-material-image-in-the-coronary-sinus-during-coronary-sinus-angiography
#11
Mustafa Yildiz Md PhD Prof, Gokhan Kahveci Md, Yunus Emiroglu Md, Okan Erdogan Md Prof
No abstract text is available yet for this article.
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908237/plant-factories-for-the-production-of-monoclonal-antibodies
#12
REVIEW
E V Sheshukova, T V Komarova, Y L Dorokhov
Like animal cells, plant cells bear mechanisms for protein synthesis and posttranslational modification (glycosylation and phosphorylation) that allow them to be seriously considered as factories for therapeutic proteins, including antibodies, with the development of biotechnology. The plant platform for monoclonal antibody production is an attractive approach due to its flexibility, speed, scalability, low cost of production, and lack of contamination risk from animal-derived pathogens. Contemporary production approaches for therapeutic proteins rely on transgenic plants that are obtained via the stable transformation of plant cells as well as the transient (temporary) expression of foreign proteins...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27908062/linguistically-guided-adaptation-to-foreign-accented-speech
#13
Angela Cooper, Ann R Bradlow
Adaptation to foreign-accented sentences can be guided by knowledge of the lexical content of those sentences, which, being an exact match for the target, provides feedback on all linguistic levels. The extent to which this feedback needs to match the accented sentence was examined by manipulating the degree of match on different linguistic dimensions, including sub-lexical, lexical, and syntactic levels. Conditions where target-feedback sentence pairs matched and mismatched generated greater transcription improvement over non-English speech feedback, indicating listeners can draw upon sources of linguistic information beyond matching lexical items, such as sub- and supra-lexical information, during adaptation...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27907820/preauricular-pilomatricoma-an-uncommon-entity-in-a-dental-pediatric-patient
#14
Poyzan Bozkurt, Mehmet Eray Kolsuz, Ömer Günhan, Erdal Erdem, Kaan Orhan
INTRODUCTION: Pilomatricomas are benign follicular skin appendage tumors, commonly occurring in children and young adults. Most patients admit to dermatologists to seek treatment and are well known by them; however, dental professionals, especially pediatric dentists are not familiar with these tumors. PRESENTATION OF CASE: This report presents a 16-year-old female with preauricular pilomatricoma, located beneath the overlying skin of the temporomandibular region...
November 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27907816/nucleic-acid-sensing-tlrs-trafficking-and-regulation
#15
REVIEW
Olivia Majer, Bo Liu, Gregory M Barton
Toll-like receptors (TLRs) play an important role in innate immune responses against pathogenic microorganisms or tissue damage. Nucleic acid (NA)-sensing TLRs localize in intracellular vesicular compartments and recognize foreign-derived and host-derived nucleic acid ligands. Inappropriate activation of NA-sensing TLRs can cause pathogenic inflammation and autoimmunity. Multiple regulatory mechanisms exist to limit recognition of self-NAs. This review summarizes recent progress that has been made in understanding how NA-sensing TLRs are regulated via trafficking, proteolytic cleavage, as well as ligand processing and recognition...
November 28, 2016: Current Opinion in Immunology
https://www.readbyqxmd.com/read/27906854/a-bullet-lying-next-to-the-common-carotid-artery-in-the-neck-of-a-young-boy
#16
Gülpembe Bozkurt, Meltem Esen Akpinar, Özlem Ünsal, Berna Uslu Coşkun
Penetrating neck trauma is most commonly caused by firearm discharge, and is potentially very dangerous, being associated with a high risk of mortality. A 12-year-old patient with a recent history of a gunshot wound to the neck was evaluated in detail; a bullet was located in close proximity to the left common carotid artery. Neck exploration was performed and the foreign body was removed without any complications. The management of the patient is discussed, as are contemporary approaches to the treatment of penetrating neck trauma...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27905679/care-management-for-foreign-children-adolescents-young-adults-with-cancer-and-their-families
#17
Jérémie Gaudichon, Sandra Toscani, Sarah Cohen-Gogo, Juliette Saulpic, Aurore Surun, Oya Sakiroglu, François Doz, Jean Michon, Daniel Orbach
BACKGROUND: Little is known about care management for foreign patients in pediatric oncology in European centers. We aimed to describe care given to children, adolescents, and young adults who came to France for cancer treatment, and to determine whether their geographical origin had an influence on decision making. PROCEDURE: We conducted a monocentric retrospective study on all foreign patients aged 0-25 years and hospitalized for at least one night in Institut Curie (Paris, France) from 2009 to 2013...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27905116/unparalleled-replacement-of-native-mitochondrial-genes-by-foreign-homologs-in-a-holoparasitic-plant
#18
M Virginia Sanchez-Puerta, Laura E García, Josefina Wohlfeiler, Luis F Ceriotti
Horizontal gene transfer (HGT) among flowering plant mitochondria occurs frequently and, in most cases, leads to nonfunctional transgenes in the recipient genome. Parasitic plants are particularly prone to this phenomenon, but their mitochondrial genomes (mtDNA) have been largely unexplored. We undertook a large-scale mitochondrial genomic study of the holoparasitic plant Lophophytum mirabile (Balanophoraceae). Comprehensive phylogenetic analyses were performed to address the frequency, origin, and impact of HGT...
November 30, 2016: New Phytologist
https://www.readbyqxmd.com/read/27904842/the-challenges-of-cardiothoracic-surgery-practice-in-nigeria-a-12-years-institutional-experience
#19
Bode Falase, Michael Sanusi, Adeola Animasahun, Ogadinma Mgbajah, Adetinuwe Majekodunmi, Onyekwelu Nzewi, Jonathan Nwiloh, David Oke
BACKGROUND: Although the specialty of cardiothoracic surgery has been practiced in Nigeria for many years, open heart surgery (OHS) has only in the last decade become relatively more frequent, mainly through visiting foreign cardiac surgical teams. At this early phase of development it is faced with multiple challenges, especially financing and local skilled manpower for which solutions have to be identified in order to ensure sustainability and future growth. This study is aimed at highlighting these obstacles to growth of cardiothoracic surgery based on our own institutional experience at Lagos State University Teaching Hospital (LASUTH) and the current status of OHS activity in other cardiothoracic centers in Nigeria...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27904758/penetrating-thoracic-spinal-cord-injury-with-ice-pick-extending-into-the-aorta-a-technical-note-and-review-of-the-literature
#20
Rani Nasser, Jonathan Nakhla, Saadat Sharif, Merritt Kinon, Reza Yassari
BACKGROUND: Penetrating spinal cord injuries pose a great challenge to both patients and the treating physicians. Although the overall incidence of penetrating spinal cord injury is the highest in the military, the ubiquity of guns in our society continues to make penetrating spinal cord injury prevalent in the civilian population. These types of injuries are particularly complicated because, beyond the trauma to the neural elements and supporting structures, other organs can be affected and a team approach is required for successful treatment...
2016: Surgical Neurology International
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