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https://www.readbyqxmd.com/read/29150669/genome-wide-survey-indicates-diverse-physiological-roles-of-the-turnip-brassica-rapa-var-rapa-calcium-dependent-protein-kinase-genes
#1
Qiuli Wang, Xin Yin, Qian Chen, Nan Xiang, Xudong Sun, Yunqiang Yang, Yongping Yang
Calcium-dependent protein kinases (CDPKs) as crucial sensors of calcium concentration changes play important roles in responding to abiotic and biotic stresses. In this study, 55 BrrCDPK genes, which were phylogenetically clustered into four subfamilies, were identified. Chromosome locations indicated that the CDPK family in turnip expanded by segmental duplication and genome rearrangement. Moreover, gene expression profiles showed that different BrrCDPKs were expressed in specific tissues or stages. Transcript levels of BrrCDPKs indicated that they were involved in abiotic and biotic stresses and that paralogs exhibited functional divergence...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150369/trial-registration-in-pediatric-surgery-trials
#2
Sana Rokhsefat, Deanna E Morra, Martin Offringa, Lisa M Askie, Lauren E Kelly
BACKGROUND: Prospective clinical trial registration serves to increase transparency and to mitigate selective reporting bias. An assessment of adult surgical trials revealed poor trial registration practice with incomplete provision of information in registries and inconsistent information in the corresponding publication. The extent and completeness of pediatric surgical trial registration are unknown. We aimed to determine the proportion and adequacy of clinical trial registration in pediatric surgery trials published in 2014...
October 23, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29150183/genetic-analysis-of-29-y-str-loci-in-the-chinese-han-population-from-shanghai
#3
Yuxiang Zhou, Chengchen Shao, Liming Li, Yaqi Zhang, Baonian Liu, Qinrui Yang, Qiqun Tang, Shilin Li, Jianhui Xie
The analysis of Y chromosomal short tandem repeats (Y-STRs) provides important information that can be used to forensic investigation and population studies. In this study, typing of 29 Y-STRs included in the PowerPlex(®) Y23 system (PPY23) and Yfiler™ Plus system (Yfiler plus) was performed on 843 unrelated male samples from Han population in Shanghai. Besides null, duplicate, and intermediate alleles reported in previous studies, an allele of 10 at DYS643 with a 2-base deletion in the flanking region was initially observed...
November 11, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29149249/human-accelerated-regions-and-other-human-specific-sequence-variations-in-the-context-of-evolution-and-their-relevance-for-brain-development
#4
Anastasia Levchenko, Alexander Kanapin, Anastasia Samsonova, Raul Gainetdinov
The review discusses, in a format of a timeline, the studies of different types of genetic variants, present in Homo sapiens, but absent in all other primate, mammalian or vertebrate species, tested so far. The main characteristic of these variants is that they are found in regions of high evolutionary conservation. These sequence variations include single nucleotide substitutions (called human accelerated regions), deletions and segmental duplications. The rationale for finding such variations in the human genome is that they could be responsible for traits, specific to our species, of which the human brain is the most remarkable...
November 14, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29149142/mapping-the-association-between-vitamin-d-and-low-back-pain-a-systematic-review-and-meta-analysis-of-observational-studies
#5
Joshua Zadro, Debra Shirley, Manuela Ferreira, Ana Paula Carvalho-Silva, Sarah E Lamb, Cyrus Cooper, Paulo H Ferreira
BACKGROUND: Low back pain (LBP) is the highest contributor to disability worldwide, with current intervention strategies only providing small to moderate analgesic effects. The use of vitamin D supplementation for LBP has gained interest due to its proposed anti-inflammatory and neuromodulatory properties. However, it is still unclear whether vitamin D levels differ between those with and without LBP or if vitamin D levels are associated with pain intensity. OBJECTIVES: We aim to investigate the association between vitamin D levels and LBP and to determine if vitamin D levels correlate with pain intensity in individuals with LBP...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148972/rapid-dna-replication-origin-licensing-protects-stem-cell-pluripotency
#6
Jacob Peter Matson, Raluca Dumitru, Philip Coryell, Ryan M Baxley, Weili Chen, Kirk Twaroski, Beau R Webber, Jakub Tolar, Anja-Katrin Bielinsky, Jeremy E Purvis, Jeanette Gowen Cook
Complete and robust human genome duplication requires loading MCM helicase complexes at many DNA replication origins, an essential process termed origin licensing. Licensing is restricted to G1 phase of the cell cycle, but G1 length varies widely among cell types. Using quantitative single cell analyses we found that pluripotent stem cells with naturally short G1 phases load MCM much faster than their isogenic differentiated counterparts with long G1 phases. During the earliest stages of differentiation towards all lineages, MCM loading slows concurrently with G1 lengthening, revealing developmental control of MCM loading...
November 17, 2017: ELife
https://www.readbyqxmd.com/read/29148523/nephrotic-syndrome-and-duplication-of-the-inferior-vena-cava-a-series-of-unfortunate-events
#7
Katarzyna Klejna, Tomasz Hryszko, Radosław Zawadzki, Beata Naumnik
No abstract text is available yet for this article.
November 17, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29148121/position-accuracy-of-implant-analogs-on-3d-printed-polymer-versus-conventional-dental-stone-casts-measured-using-a-coordinate-measuring-machine
#8
Marta Revilla-León, Óscar Gonzalez-Martín, Javier Pérez López, José Luis Sánchez-Rubio, Mutlu Özcan
PURPOSE: To compare the accuracy of implant analog positions on complete edentulous maxillary casts made of either dental stone or additive manufactured polymers using a coordinate measuring machine (CMM). MATERIAL AND METHODS: A completely edentulous maxillary model of a patient with 7 implant analogs was obtained. From this model, two types of casts were duplicated, namely conventional dental stone (CDS) using a custom tray impression technique after splinting (N = 5) and polymer cast using additive manufacturing based on the STL file generated...
November 17, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29147915/use-of-enzyme-linked-immunosorbent-assay-to-screen-for-aflatoxins-ochratoxin-a-and-deoxynivalenol-in-dry-pet-foods
#9
Tara A Okuma, Thu P Huynh, Rosalee S Hellberg
The objective of this study was to perform a market survey on dry pet foods using enzyme-linked immunosorbent assay (ELISA) to detect total aflatoxins (AFs), ochratoxin A (OTA), and deoxynivalenol (DON). Pet food products (n = 58) marketed for dogs, cats, birds, and rabbits were tested in duplicate with ELISA, and results above the limit of quantitation were confirmed using liquid chromatography tandem mass spectrometry (LC-MS/MS). OTA was detected in one product (rabbit food) and AFs were detected in two products (one dog treat and one bird treat)...
November 16, 2017: Mycotoxin Research
https://www.readbyqxmd.com/read/29147671/distal-22q11-2-microduplication-case-report-and-review-of-the-literature
#10
Elana Pinchefsky, Laurence Laneuville, Myriam Srour
Distal chromosome 22q11.2 microduplications are associated with a wide range of phenotypes and unclear pathogenicity. The authors report on a 3-year-old girl with global developmental delay harboring a de novo 1.24 Mb distal chromosome 22q11.2 microduplication and a paternally inherited 0.25 Mb chromosome 4p14 microduplication. The authors review clinical features of 30 reported cases of distal 22q11.2 duplications. Common features include developmental delay (93%), neuropsychiatric features (26%), and nonspecific facial dysmorphisms (74%)...
January 2017: Child neurology open
https://www.readbyqxmd.com/read/29146914/cat-d-a-targeted-sequencing-method-for-the-simultaneous-detection-of-small-dna-mutations-and-large-dna-deletions-with-flexible-boundaries
#11
Ru Hong, Udita Chandola, Li-Feng Zhang
We developed a targeted DNA sequencing method that is capable of detecting a comprehensive panel of DNA mutations including small DNA mutations and large DNA deletions with unknown/flexible boundaries. The method directly identifies the large DNA deletions (Cat-D) without relying on sequencing coverage to make the genotype calls. We performed the method to simultaneously detect 10 small DNA mutations in β-thalassemia and 2 large genomic deletions in α-thalassemia from 10 genomic DNA samples. Cat-D was performed on 8 genomic DNA samples in duplicate...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146812/evolution-of-flower-color-pattern-through-selection-on-regulatory-small-rnas
#12
Desmond Bradley, Ping Xu, Irina-Ioana Mohorianu, Annabel Whibley, David Field, Hugo Tavares, Matthew Couchman, Lucy Copsey, Rosemary Carpenter, Miaomiao Li, Qun Li, Yongbiao Xue, Tamas Dalmay, Enrico Coen
Small RNAs (sRNAs) regulate genes in plants and animals. Here, we show that population-wide differences in color patterns in snapdragon flowers are caused by an inverted duplication that generates sRNAs. The complexity and size of the transcripts indicate that the duplication represents an intermediate on the pathway to microRNA evolution. The sRNAs repress a pigment biosynthesis gene, creating a yellow highlight at the site of pollinator entry. The inverted duplication exhibits steep clines in allele frequency in a natural hybrid zone, showing that the allele is under selection...
November 17, 2017: Science
https://www.readbyqxmd.com/read/29146770/environmental-population-and-life-stage-plasticity-in-the-visual-system-of-atlantic-cod
#13
Ragnhild Valen, Rita Karlsen, Jon Vidar Helvik
The visual system is for many fishes essential in guiding behaviors such as foraging, predator avoidance and mate choice. The marine environment is characterized by large spatiotemporal fluctuations in light intensity and spectral composition. However, visual capabilities are restricted by both space limitations set by eye size, and by the genomic content of light absorbing opsin genes. The rich array of visual opsins in teleosts may be used differentially to tune vision towards specific needs during ontogeny, and to changing light...
November 16, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29146759/visual-field-indices-and-patterns-of-visual-field-deficits-in-mesopic-and-dark-adapted-two-colour-fundus-controlled-perimetry-in-macular-diseases
#14
Maximilian Pfau, Moritz Lindner, Julia S Steinberg, Sarah Thiele, Christian K Brinkmann, Monika Fleckenstein, Frank G Holz, Steffen Schmitz-Valckenberg
BACKGROUND/AIMS: To analyse the retest reliability of visual field indices and to describe patterns of visual field deficits in mesopic and dark-adapted two-colour fundus-controlled perimetry (FCP) in macular diseases. METHODS: Seventy-seven eyes (30 eyes with macular diseases and 47 normal eyes) underwent duplicate mesopic and dark-adapted two-colour FCP (Scotopic Macular Integrity Assessment, CenterVue). Non-weighted (mean defect, loss variance), variability-weighted (mean deviation, pattern standard deviation (PSD)) and graphical (cumulative defect (Bebie) curves) indices were computed...
November 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29146169/arthroscopy-after-traumatic-hip-dislocation-a%C3%A2-systematic-review-of-intra-articular-findings-correlation-with-magnetic-resonance-imaging-and-computed-tomography-treatments-and-outcomes
#15
REVIEW
Jacob C Mandell, Richard A Marshall, Michael B Banffy, Bharti Khurana, Michael J Weaver
PURPOSE: To describe the literature concerning patient demographic characteristics and intra-articular injury seen at arthroscopy after traumatic hip dislocation, describe the reported computed tomography (CT) and magnetic resonance findings with arthroscopic correlation, and describe the reported arthroscopic treatments performed with complications and outcomes. METHODS: A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for assessment of arthroscopy after hip dislocation...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29145248/esophageal-duplication-cyst-with-hemivertebrae-a-case-report-and-literature-review
#16
Yanfang Liu, Ling Zhou, Shuixue Li, Jun He, Abudusaimi, Kai Li, Aziguli, Haixia Yao
BACKGROUND: Esophageal duplication cysts (EDCs) are rare congenital anomalies that can be associated with symptomatic spinal abnormalities, but presentations due to EDC symptoms are rarely found in the presence of spinal abnormalities. CASE SUMMARY: A 6-month-old infant weighing approximately 5.0 kg presented with a 2-month pulmonary infection and more recent difficulty swallowing and nutritional intolerance that did not improve with medical treatment. Contrast-enhanced chest computed tomography showed a well-defined, mediastinal, homogeneous, low-density cystic mass of 11...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145202/exploring-the-association-between-statin-use-and-the-risk-of-parkinson-s-disease-a-meta-analysis-of-observational-studies
#17
Tahmina Nasrin Poly, Md Mohaimenul Islam, Bruno Andreas Walther, Hsuan-Chia Yang, Phung-Anh Nguyen, Chih-Wei Huang, Syed-Abdul Shabbir, Yu-Chuan Jack Li
BACKGROUND: Parkinson's disease (PD) is a progressive disorder of the central nervous system. The prevalence of PD varies considerably by age group; it has a higher prevalence in patients aged 60 years and more. Several studies have shown that statin, a cholesterol-lowering medication, reduces the risk of developing PD, but evidence for this is so far inconclusive. The objective of this study is to evaluate the association between statin use and the risk of developing PD. METHODS: PubMed, EMBASE, and the bibliographies of articles were searched for studies published between January 1, 1990, and January 1, 2017, which reported on the association between statin use and PD...
November 16, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29144734/physically-unclonable-cryptographic-primitives-by-chemical-vapor-deposition-of-layered-mos2
#18
Abdullah Alharbi, Darren Armstrong, Somayah Alharbi, Davood Shahrjerdi
Physically unclonable cryptographic primitives are promising for securing the rapidly growing number of electronic devices. Here, we introduce a new class of physically unclonable primitives from layered molybdenum disulfide (MoS2) by leveraging the natural randomness of their island growth during chemical vapor deposition (CVD). We synthesize a MoS2 monolayer film covered with speckles of multilayer islands, where the growth process is engineered for an optimal speckle density. Using the Clark-Evans test, we confirm that the distribution of islands on the film exhibits complete spatial randomness, hence indicating the growth of multilayer speckles is a spatial Poisson process...
November 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/29144427/the-chloroplast-genome-of-symplocarpus-renifolius-a-comparison-of-chloroplast-genome-structure-in-araceae
#19
Kyoung Su Choi, Kyu Tae Park, SeonJoo Park
Symplocarpus renifolius is a member of Araceae family that is extraordinarily diverse in appearance. Previous studies on chloroplast genomes in Araceae were focused on duckweeds (Lemnoideae) and root crops (Colocasia, commonly known as taro). Here, we determined the chloroplast genome of Symplocarpus renifolius and compared the factors, such as genes and inverted repeat (IR) junctions and performed phylogenetic analysis using other Araceae species. The chloroplast genome of S. renifolius is 158,521 bp and includes 113 genes...
November 16, 2017: Genes
https://www.readbyqxmd.com/read/29144405/genomic-analysis-of-the-asmt-gene-family-in-solanum-lycopersicum
#20
Weicheng Liu, Dake Zhao, Chunfang Zheng, Chen Chen, Xin Peng, Yuan Cheng, Hongjian Wan
Acetylserotonin methyltransferase (ASMT) is the last enzyme of melatonin biosynthesis and may play a rate-limiting role in the melatonin production of plants. In this study, systematic analysis of the ASMT gene family in tomato (Solanum lycopersicum Mill) has been presented by the integration of the structural features, phylogenetic relationships, exon/intron configuration, and expression profile during growth and development, as well as biotic stresses. The results revealed that the tomato genome encoded a minimum of 14 members, containing three probable encoded pseudogenes...
November 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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