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Cristina Carrera, Sonia Segura, Paula Aguilera, Carol Midori Takigami, Antonio Gomes, Alicia Barreiro, Massimiliano Scalvenzi, Caterina Longo, Stefano Cavicchini, Luc Thomas, Josep Malvehy, Susana Puig, Iris Zalaudek
BACKGROUND: Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value of dermoscopy to improve the correct detection of these mimickers has not been previously studied. OBJECTIVE: To evaluate the diagnostic accuracy of clinically SK-like MMs with and without dermoscopy. METHODS: Clinical and dermoscopic images of histopathologically proven SK-like MMs (n = 134) intermingled with other melanomas and benign tumors were randomly presented to clinicians with different levels of experience, blinded to the diagnosis and goal of the study...
March 2, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
Marie De Loof, Jo Van Dorpe, Joni Van Der Meulen, Steve Lefever, Ingeborg Dhooge
BACKGROUND: Seborrheic keratosis (SK) of the outer ear canal is rarely described in literature. Etiological risk factors involved in SK such as exposure to human papillomavirus (HPV) and ultraviolet (UV) light are established but must still be confirmed. In recent years, new insights into the pathogenesis of SKs occurred in the area of molecular pathogenesis. Fibroblast growth factor receptor 3 (FGFR3) gene and p110α subunit of phosphoinositide 3-kinase (PIK3CA) oncogene mutations are known to be involved...
February 27, 2018: International Journal of Dermatology
Cinzia Borgogna, Carlotta Olivero, Simone Lanfredini, Federica Calati, Marco De Andrea, Elisa Zavattaro, Paola Savoia, Elena Trisolini, Renzo Boldorini, Girish K Patel, Marisa Gariglio
Many malignancies that occur in high excess in kidney transplant recipients (KTRs) are due to viruses that thrive in the setting of immunosuppression. Keratinocyte carcinoma (KC), the most frequently occurring cancer type in KTR, has been associated with skin infection by human papillomavirus (HPV) from the beta genus. In this report, we extend our previous investigation aimed at identifying the presence of active β-HPV infection in skin tumors from KTRs through detection of viral protein expression. Using a combination of antibodies raised against the E4 and L1 proteins of the β-genotypes, we were able to visualize infection in five tumors [one keratoacanthoma (KA), three actinic keratoses (AKs), and one seborrheic keratoses (SKs)] that were all removed from two patients who had been both transplanted twice, had developed multiple KCs, and presented with a long history of immunosuppression (>30 years)...
2018: Frontiers in Microbiology
N Houlié, J Woessner, D Giardini, M Rothacher
In this study we test whether principal components of the strain rate and stress tensors align within Switzerland. We find that 1) Helvetic Nappes line (HNL) is the relevant tectonic boundary to define different domains of crustal stress/surface strain rates orientations and 2) orientations of T- axes (of moment tensor solutions) and long-term asthenosphere cumulative finite strain (from SKS shear wave splitting) are consistent at the scale of the Alpine arc in Switzerland. At a more local scale, we find that seismic activity and surface deformation are in agreement but in three regions (Basel, Swiss Jura and Ticino); possibly because of the low levels of deformation and/or seismicity...
January 31, 2018: Scientific Reports
Baasanjav Uranbileg, Takeshi Nishikawa, Hitoshi Ikeda, Makoto Kurano, Masaya Sato, Daisuke Saigusa, Junken Aoki, Toshiaki Watanabe, Yutaka Yatomi
BACKGROUND: A pivotal role of sphingosine 1-phosphate (S1P) in cancer has been suggested based on the ceramide-S1P rheostat theory that the intracellular balance between prosurvival S1P and proapoptotic ceramide determines cell fate. Upregulation of S1P-generating sphingosine kinases (SKs) and downregulation of S1P-degrading S1P lyase (SPL) might increase intracellular S1P levels to exert a prosurvival effect in cancer in general, such as colon cancer. However, we recently observed a distinct S1P metabolism in hepatocellular carcinoma tissues that increased SPL mRNA levels with reduced S1P levels...
November 21, 2017: Clinical Colorectal Cancer
Young-Woo Nam, Razan Orfali, Tingting Liu, Kunqian Yu, Meng Cui, Heike Wulff, Miao Zhang
Small-conductance Ca2+ -activated K+ (SK) channels play essential roles in the regulation of cellular excitability and have been implicated in neurological and cardiovascular diseases through both animal model studies and human genetic association studies. Over the past two decades, positive modulators of SK channels such as NS309 and 1-EBIO have been developed. Our previous structural studies have identified the binding pocket of 1-EBIO and NS309 that is located at the interface between the channel and calmodulin...
December 7, 2017: Scientific Reports
Suresh K Verma, Ealisha Jha, Pritam Kumar Panda, Jugal K Das, Arun Thirumurugan, Mrutyunjay Suar, Sks Parashar
AIM: To investigate molecular aspects of the antibacterial effect of size-dependent core-shell intrinsic defects of nanocrystalline ZnO synthesized through high energy ball milling technique. MATERIALS & METHODS: Mechanically synthesized and characterized 7, 10 and 15 h milled ZnO nanoparticles were evaluated for antibacterial activity with molecular investigation by computational molecular docking. RESULTS: Synthesized ZnO nanoparticles displayed shrinkage of core and increase of shell with reduction in size of bulk ZnO particles from 250 to 80, 40 and 20 nm and increase in zeta potential up to -19 mV in 7, 10 and 15 h nano ZnO...
January 2018: Nanomedicine
Yongfei Cai, Mingyang Su, Ashfaq Ahmad, Xiaojie Hu, Jiayan Sang, Lingyuan Kong, Xingqiang Chen, Chen Wang, Jianwei Shuai, Aidong Han
Two-component systems (TCSs) are key elements in bacterial signal transduction in response to environmental stresses. TCSs generally consist of sensor histidine kinases (SKs) and their cognate response regulators (RRs). Many SKs exhibit autokinase, phosphoryltransferase and phosphatase activities, which regulate RR activity through a phosphorylation and dephosphorylation cycle. However, how SKs perform different enzymatic activities is poorly understood. Here, several crystal structures of the minimal catalytic region of WalK, an essential SK from Lactobacillus plantarum that shares 60% sequence identity with its homologue VicK from Streptococcus mutans, are presented...
October 1, 2017: Acta Crystallographica. Section D, Structural Biology
Janet C DuBois, Michael Jarratt, Brian B Beger, Mark Bradshaw, Christopher V Powala, Stuart D Shanler
BACKGROUND: Seborrheic keratosis (SK) is a common benign skin tumor, yet no topical treatments are approved in the United States. OBJECTIVE: To evaluate the proprietary, stabilized, high-concentration hydrogen peroxide-based topical solution A-101 (32.5% and 40% concentrations) for treatment of facial SK lesions. MATERIALS AND METHODS: In this multicenter, double-blind, vehicle-controlled study, eligible subjects were randomly assigned to receive up to 2 treatments of A-101 40%, A-101 32...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
G Gordo, J Tenorio, P Arias, F Santos-Simarro, S García-Miñaur, J C Moreno, J Nevado, E Vallespin, L Rodriguez-Laguna, R de Mena, I Dapia, M Palomares, Á Del Pozo, K Ibañez, J C Silla, E Barroso, V L Ruiz Pérez, V Martinez-Glez, P Lapunzina
Smith-Kingsmore syndrome (SKS) OMIM #616638, also known as MINDS syndrome (ORPHA: 457485), is a rare autosomal dominant disorder reported so far in 23 patients. SKS is characterized by intellectual disability, macrocephaly/hemi/megalencephaly, and seizures. It is also associated with a pattern of facial dysmorphology and other non-neurological features. Germline or mosaic mutations of the mTOR gene have been detected in all patients. The mTOR gene is a key regulator of cell growth, cell proliferation, protein synthesis and synaptic plasticity, and the mTOR pathway (PI3K-AKT-mTOR) is highly regulated and critical for cell survival and apoptosis...
September 11, 2017: Clinical Genetics
Francesco Lacarrubba, Maria Rita Nasca, Anna Elisa Verzì, Giuseppe Micali
In this proof of concept study, 50 lesions from 15 patients with multiple seborrheic keratoses (SKs) were treated with a novel aqueous solution containing nitric acid, zinc and copper salts, and organic acids (acetic, lactic, and oxalic acid). Treatment consisted in the application of an amount of the solution sufficient to obtain a whitening/yellowish reaction. Application of the nitric-zinc solution was performed every other week until clinical and dermoscopic clearance or crust formation, for a maximum of 4 applications...
September 2017: Dermatologic Therapy
Ping Zhang, Daiqi Chen, Daishi Tian, Qiang Zhang, Minghuan Wang, Qian Li, Xiang Luo
Atherosclerotic stenosis or occlusion often involves the subclavian artery. For lesions that are close to the orifice of the right subclavian artery, stenting of the right subclavian artery itself blocks the pathway from the innominate artery to the right carotid artery and causes problems in patients with multiple angiostenosis, especially involving the right carotid system. In this study, we report 2 cases using simultaneous kissing stenting (SKS) of the right subclavian artery and the right carotid artery to relieve right subclavian stenosis and maintain right carotid system patency...
March 2017: Interventional Neurology
Garrett S Bullock, Abigail C Schmitt, Jason M Shutt, Gray Cook, Robert J Butler
BACKGROUND: Kettlebell (KB) and indian club swings (ICS) are used diversely for developing strength and power. It has been proposed that multiple swing techniques can be used interchangeably to elicit similar adaptations within performance training. Hypothesis/Purpose: It was hypothesized that there will be not be a difference in peak joint angles between types of swings. Furthermore, given the nature of the overhead kettlebell swing (OKS), it was hypothesized that the OKS will be associated with a greater cycle time and a greater vertical impulse compared to shoulder height swing (SKS) and ICS...
June 2017: International Journal of Sports Physical Therapy
Priyadarshi Amit, Sumeet Rastogi, Sks Marya
Infected total knee arthroplasty (TKA) due to Mycobacterium abscessus is very rare with only three such cases described in literature. Only one case was managed successfully, however, with a prolonged course of anti tubercular therapy. In this case report, we present an elderly lady with infected TKA after 2 years of the primary procedure. Although initially it grew different bacteriae, M. abscessus was isolated during the second debridement. She was successfully treated with total of 5 months of second line anti tubercular drugs with revision prosthesis performed during chemotherapy...
May 2017: Indian Journal of Orthopaedics
Trupti S Chitre, Kalyani D Asgaonkar, Shital M Patil, Shiva Kumar, Vijay M Khedkar, Dinesh R Garud
The enzyme - enoyl acyl carrier protein reductase (enoyl ACP reductase) is a validated target for antitubercular activity. Inhibition of this enzyme interferes with mycolic acid synthesis which is crucial for Mycobacterium tuberculosis cell growth. In the present work 2D and 3D quantitative structure activity relationship (QSAR) studies were carried out on a series of thiazinan-Isoniazid pharmacophore to design newer analogues. For 2D QSAR, the best statistical model was generated using SA-MLR method (r(2)=0...
March 30, 2017: Computational Biology and Chemistry
Navnina Bhatia, David Tisseur, Jean Michel Létang
One of the well-recognized challenge of Cone-Beam Computed Tomography (CBCT) is scatter contamination within the projection images. Scatter degrades the image quality by decreasing the contrast, introducing cupping and shading artifacts and thus leading to inaccuracies in the reconstructed values. The higher scatter to primary ratio experienced in industrial applications leads to even more important artifacts. Various strategies have been investigated to manage the scatter signal in CBCT projection data. One of these strategies is to calculate the scatter intensity by deconvolution of primary intensity using Scatter Kernel Superposition (SKS)...
April 5, 2017: Journal of X-ray Science and Technology
Cristina Carrera, Sonia Segura, Paula Aguilera, Massimiliano Scalvenzi, Caterina Longo, Alicia Barreiro, Paolo Broganelli, Stefano Cavicchini, Alex Llambrich, Pedro Zaballos, Luc Thomas, Josep Malvehy, Susana Puig, Iris Zalaudek
Importance: Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas. Objective: To describe the dermoscopic features of SK-like melanomas to understand their clinical morphology. Design, Setting, and Participants: This observational retrospective study used 134 clinical and dermoscopic images of histopathologically proven melanomas in 134 patients treated in 9 skin cancer centers in Spain, France, Italy, and Austria...
June 1, 2017: JAMA Dermatology
Fauzia Shaikh, Marjorie G Zauderer, Donata von Reibnitz, Abraham J Wu, Ellen D Yorke, Amanda Foster, Weiji Shi, Zhigang Zhang, Prasad S Adusumilli, Kenneth E Rosenzweig, Lee M Krug, Valerie W Rusch, Andreas Rimner
INTRODUCTION: Higher target conformity and better sparing of organs at risk with modern radiotherapy (RT) may result in higher tumor control and less toxicity. In this study, we compare our institutional multimodality therapy experience of adjuvant chemotherapy and hemithoracic intensity-modulated pleural RT (IMPRINT) with previously used adjuvant conventional RT (CONV) in patients with malignant pleural mesothelioma (MPM) treated with lung-sparing pleurectomy/decortication (P/D)...
June 2017: Journal of Thoracic Oncology
Malihe Keramati, Mohammad Mehdi Aslani, Shohreh Khatami, Farzin Roohvand
OBJECTIVE: To gain insights on the degree of heterogeneity and kinetic differences of streptokinase (SK) from group G (SKG) Streptococci compared with standard SK from group C (SKC) and identification of potentially contributing critical residues (hotspots). RESULTS: DNA and sequencing analyses confirmed the proper construction of all SK encoding vectors (two SKGs and one standard SKC). SDS-PAGE and western blot analyses confirmed the expression and proper purification of the recombinant SKs from E...
June 2017: Biotechnology Letters
Viji Nair, Cassianne Robinson-Cohen, Michelle R Smith, Keith A Bellovich, Zeenat Yousuf Bhat, Maria Bobadilla, Frank Brosius, Ian H de Boer, Laurent Essioux, Ivan Formentini, Crystal A Gadegbeku, Debbie Gipson, Jennifer Hawkins, Jonathan Himmelfarb, Bryan Kestenbaum, Matthias Kretzler, Maria Chiara Magnone, Kalyani Perumal, Susan Steigerwalt, Wenjun Ju, Nisha Bansal
Growth differentiation factor-15 (GDF-15) is a member of the TGF-β cytokine superfamily that is widely expressed and may be induced in response to tissue injury. Elevations in GDF-15 may identify a novel pathway involved in loss of kidney function among patients with CKD. Among participants in the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS), we tested whether kidney tissue expression of GDF15 mRNA correlates with circulating levels of GDF-15 and whether elevations in circulating GDF-15 are associated with decline in kidney function...
July 2017: Journal of the American Society of Nephrology: JASN
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