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https://www.readbyqxmd.com/read/28611836/simultaneous-kissing-stenting-a-valuable-technique-for-reconstructing-the-stenotic-initial-segment-of-the-right-subclavian-artery
#1
Ping Zhang, Daiqi Chen, Daishi Tian, Qiang Zhang, Minghuan Wang, Qian Li, Xiang Luo
Atherosclerotic stenosis or occlusion often involves the subclavian artery. For lesions that are close to the orifice of the right subclavian artery, stenting of the right subclavian artery itself blocks the pathway from the innominate artery to the right carotid artery and causes problems in patients with multiple angiostenosis, especially involving the right carotid system. In this study, we report 2 cases using simultaneous kissing stenting (SKS) of the right subclavian artery and the right carotid artery to relieve right subclavian stenosis and maintain right carotid system patency...
March 2017: Interventional Neurology
https://www.readbyqxmd.com/read/28593086/kinematic-and-kinetic-variables-differ-between-kettlebell-swing-styles
#2
Garrett S Bullock, Abigail C Schmitt, Jason M Shutt, Gray Cook, Robert J Butler
BACKGROUND: Kettlebell (KB) and indian club swings (ICS) are used diversely for developing strength and power. It has been proposed that multiple swing techniques can be used interchangeably to elicit similar adaptations within performance training. Hypothesis/Purpose: It was hypothesized that there will be not be a difference in peak joint angles between types of swings. Furthermore, given the nature of the overhead kettlebell swing (OKS), it was hypothesized that the OKS will be associated with a greater cycle time and a greater vertical impulse compared to shoulder height swing (SKS) and ICS...
June 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28566789/prosthetic-knee-joint-infection-due-to-mycobacterium-abscessus
#3
Priyadarshi Amit, Sumeet Rastogi, Sks Marya
Infected total knee arthroplasty (TKA) due to Mycobacterium abscessus is very rare with only three such cases described in literature. Only one case was managed successfully, however, with a prolonged course of anti tubercular therapy. In this case report, we present an elderly lady with infected TKA after 2 years of the primary procedure. Although initially it grew different bacteriae, M. abscessus was isolated during the second debridement. She was successfully treated with total of 5 months of second line anti tubercular drugs with revision prosthesis performed during chemotherapy...
May 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28411471/qsar-docking-studies-of-1-3-thiazinan-3-yl-isonicotinamide-derivatives-for-antitubercular-activity
#4
Trupti S Chitre, Kalyani D Asgaonkar, Shital M Patil, Shiva Kumar, Vijay M Khedkar, Dinesh R Garud
The enzyme - enoyl acyl carrier protein reductase (enoyl ACP reductase) is a validated target for antitubercular activity. Inhibition of this enzyme interferes with mycolic acid synthesis which is crucial for Mycobacterium tuberculosis cell growth. In the present work 2D and 3D quantitative structure activity relationship (QSAR) studies were carried out on a series of thiazinan-Isoniazid pharmacophore to design newer analogues. For 2D QSAR, the best statistical model was generated using SA-MLR method (r(2)=0...
March 30, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28387696/convolution-based-scatter-correction-using%C3%A2-kernels-combining-measurements-and%C3%A2-monte-carlo-simulations
#5
Navnina Bhatia, David Tisseur, Jean Michel Létang
One of the well-recognized challenge of Cone-Beam Computed Tomography (CBCT) is scatter contamination within the projection images. Scatter degrades the image quality by decreasing the contrast, introducing cupping and shading artifacts and thus leading to inaccuracies in the reconstructed values. The higher scatter to primary ratio experienced in industrial applications leads to even more important artifacts. Various strategies have been investigated to manage the scatter signal in CBCT projection data. One of these strategies is to calculate the scatter intensity by deconvolution of primary intensity using Scatter Kernel Superposition (SKS)...
April 5, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28355453/dermoscopic-clues-for-diagnosing-melanomas-that-resemble-seborrheic-keratosis
#6
MULTICENTER STUDY
Cristina Carrera, Sonia Segura, Paula Aguilera, Massimiliano Scalvenzi, Caterina Longo, Alicia Barreiro, Paolo Broganelli, Stefano Cavicchini, Alex Llambrich, Pedro Zaballos, Luc Thomas, Josep Malvehy, Susana Puig, Iris Zalaudek
Importance: Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas. Objective: To describe the dermoscopic features of SK-like melanomas to understand their clinical morphology. Design, Setting, and Participants: This observational retrospective study used 134 clinical and dermoscopic images of histopathologically proven melanomas in 134 patients treated in 9 skin cancer centers in Spain, France, Italy, and Austria...
June 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28341225/improved-outcomes-with-modern-lung-sparing-trimodality-therapy-in-patients-with-malignant-pleural-mesothelioma
#7
Fauzia Shaikh, Marjorie G Zauderer, Donata von Reibnitz, Abraham J Wu, Ellen D Yorke, Amanda Foster, Weiji Shi, Zhigang Zhang, Prasad S Adusumilli, Kenneth E Rosenzweig, Lee M Krug, Valerie W Rusch, Andreas Rimner
INTRODUCTION: Higher target conformity and better sparing of organs at risk with modern radiotherapy (RT) may result in higher tumor control and less toxicity. In this study, we compare our institutional multimodality therapy experience of adjuvant chemotherapy and hemithoracic intensity-modulated pleural RT (IMPRINT) with previously used adjuvant conventional RT (CONV) in patients with malignant pleural mesothelioma (MPM) treated with lung-sparing pleurectomy/decortication (P/D)...
June 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28247197/sequence-and-kinetic-analyses-of-streptokinase-from-two-group-g-streptococci-with-high-fibrin-dependent-plasminogen-activities-and-the-identification-of-novel-altered-amino-acids-as-potential-hot-spots
#8
Malihe Keramati, Mohammad Mehdi Aslani, Shohreh Khatami, Farzin Roohvand
OBJECTIVE: To gain insights on the degree of heterogeneity and kinetic differences of streptokinase (SK) from group G (SKG) Streptococci compared with standard SK from group C (SKC) and identification of potentially contributing critical residues (hotspots). RESULTS: DNA and sequencing analyses confirmed the proper construction of all SK encoding vectors (two SKGs and one standard SKC). SDS-PAGE and western blot analyses confirmed the expression and proper purification of the recombinant SKs from E...
February 28, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28159780/growth-differentiation-factor-15-and-risk-of-ckd-progression
#9
Viji Nair, Cassianne Robinson-Cohen, Michelle R Smith, Keith A Bellovich, Zeenat Yousuf Bhat, Maria Bobadilla, Frank Brosius, Ian H de Boer, Laurent Essioux, Ivan Formentini, Crystal A Gadegbeku, Debbie Gipson, Jennifer Hawkins, Jonathan Himmelfarb, Bryan Kestenbaum, Matthias Kretzler, Maria Chiara Magnone, Kalyani Perumal, Susan Steigerwalt, Wenjun Ju, Nisha Bansal
Growth differentiation factor-15 (GDF-15) is a member of the TGF-β cytokine superfamily that is widely expressed and may be induced in response to tissue injury. Elevations in GDF-15 may identify a novel pathway involved in loss of kidney function among patients with CKD. Among participants in the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS), we tested whether kidney tissue expression of GDF15 mRNA correlates with circulating levels of GDF-15 and whether elevations in circulating GDF-15 are associated with decline in kidney function...
July 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28089668/ebio-does-not-induce-cardiomyogenesis-in-human-pluripotent-stem-cells-but-modulates-cardiac-subtype-enrichment-by-lineage-selective-survival
#10
Monica Jara-Avaca, Henning Kempf, Michael Rückert, Diana Robles-Diaz, Annika Franke, Jeanne de la Roche, Martin Fischer, Daniela Malan, Philipp Sasse, Wladimir Solodenko, Gerald Dräger, Andreas Kirschning, Ulrich Martin, Robert Zweigerdt
Subtype-specific human cardiomyocytes (CMs) are valuable for basic and applied research. Induction of cardiomyogenesis and enrichment of nodal-like CMs was described for mouse pluripotent stem cells (mPSCs) in response to 1-ethyl-2-benzimidazolinone (EBIO), a chemical modulator of small-/intermediate-conductance Ca(2+)-activated potassium channels (SKs 1-4). Investigating EBIO in human pluripotent stem cells (PSCs), we have applied three independent differentiation protocols of low to high cardiomyogenic efficiency...
February 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28024903/cloning-localization-and-physiological-effects-of-sulfakinin-in-the-kissing-bug-rhodnius-prolixus
#11
Hussain Al-Alkawi, Angela B Lange, Ian Orchard
Sulfakinins (SKs) are a family of multifunctional neuropeptides that have been shown to have myotropic activity on muscles of the digestive system and to function as feeding satiety factors. Here, we confirm via cloning the presence of two sulfakinins (Rhopr-SK-1 and Rhopr-SK-2) in Rhodnius prolixus. Reverse transcriptase quantitative PCR demonstrates that the Rhopr-SK transcript is highly expressed in the central nervous system (CNS) of unfed fifth-instar R. prolixus. Fluorescent in situ hybridization shows transcript expression only in neurons in the brain...
December 23, 2016: Peptides
https://www.readbyqxmd.com/read/27903597/impact-of-organic-cation-transporters-oct-slc22a-on-differential-diagnosis-of-intrahepatic-lesions
#12
Michele Visentin, Belle V van Rosmalen, Christian Hiller, Matthanja Bieze, Lia Hofstetter, Joanne Verheij, Gerd A Kullak-Ublick, Hermann Koepsell, Saffire Sks Phoa, Ikumi Tamai, Roelof J Bennink, Thomas M van Gulik, Bruno Stieger
Positron emission tomography (PET) using the cationic compound [(18)F]fluoromethylcholine (FCH) enhances the sensitivity for non-invasive classification of hepatic tumours due to peculiar patterns of accumulation. The underlying transporters are not known. We aim to identify the carriers mediating uptake of FCH in liver and to correlate their expression pattern with PET intrahepatic signal distribution to clarify the role of membrane transporters in FCH accumulation. FCH transport was characterized in cells overexpressing organic cation transporters (OCTs)...
November 30, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27858221/-preoperative-neuropathic-component-in-patients-with-back-pain
#13
Y-J Lee, E M W Koch, J B Breidebach, R Bornemann, D C Wirtz, R Pflugmacher
BACKGROUND: The objectification of pain is essential for evaluation, treatment plan and follow-up; therefore, it is necessary to find reliable clinical parameters. OBJECTIVE: The goal of the study was the preoperative screening of a neuropathic component in patients with vertebral compression fracture (WKF), herniated disc (NPP) or spinal cord compression (SKS). MATERIAL AND METHODS: Depending on the preoperative condition on admittance, patients were classified into three groups: group 1 WKF, group 2 NPP and group 3 SKS...
November 17, 2016: Der Schmerz
https://www.readbyqxmd.com/read/27753196/smith-kingsmore-syndrome-a-third-family-with-the-mtor-mutation-c-5395g-a-p-glu1799lys-and-evidence-for-paternal-gonadal-mosaicism
#14
Shahida Moosa, Helena Böhrer-Rabel, Janine Altmüller, Filippo Beleggia, Peter Nürnberg, Yun Li, Gökhan Yigit, Bernd Wollnik
Heterozygous germline mutations in MTOR have been shown to underlie Smith-Kingsmore syndrome, a rare autosomal dominant syndrome characterized by macrocephaly, developmental delay, and dysmorphic facial features. Recently, two unrelated families with the MTOR mutation, c.5395G>A p.(Glu1799Lys), were reported. Here, we describe siblings from a non-consanguineous German family in whom we identified the same heterozygous missense mutation in MTOR. Remarkably, in all reported families with Smith-Kingsmore syndrome and the MTOR c...
January 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27666993/cloning-expression-and-characterization-of-a-cold-adapted-shikimate-kinase-from-the-psychrophilic-bacterium-colwellia-psychrerythraea-34h
#15
Wahyu Sri Kunto Nugroho, Dong-Woo Kim, Jong-Cheol Han, Young Baek Hur, Soo-Wan Nam, Hak Jun Kim
Most cold-adapted enzymes possess higher Km and kcat values than those of their mesophilic counterparts to maximize the reaction rate. This characteristic is often ascribed to a high structural flexibility and improved dynamics in the active site. However, this may be less convincing to cold-adapted metabolic enzymes, which work at substrate concentrations near Km. In this respect, cold adaptation of a shikimate kinase (SK) in the shikimate pathway from psychrophilic Colwellia psychrerythraea (CpSK) was characterized by comparing it with a mesophilic Escherichia coli homolog (EcSK)...
December 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27512194/nodulocystic-basal-cell-carcinoma-arising-directly-from-a-seborrheic-keratosis-a-rare-case-report
#16
Kana Shibao, Naoko Okiyama, Ryota Tanaka, Hitoshi Maruyama, Yasuhiro Fujisawa, Manabu Fujimoto
Seborrheic keratoses (SKs) are common epidermal tumors composed of benign keratinocytes. Malignant skin tumors including basal cell carcinoma (BCC) rarely arise within SKs. We report a rare case of an 82-year-old man with nodulocystic BCC that appeared at the center of a scaly hyperpigmented SK that had been presented for more than 10 years. It was histologically confirmed that CK19-positive BCC arose directly from the wall of the pseudohorn cyst, a part of the SK. Nodular and/or cystic BCC also rarely arise within SKs while the most common histologic type of BCC within SKs is the superficial type...
July 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27498028/protein-kinase-c-%C3%AE-inhibitor-rottlerin-inhibits-growth-and-survival-of-mycobacteria-exclusively-through-shikimate-kinase
#17
Sapna Pandey, Aditi Chatterjee, Swati Jaiswal, Sanjay Kumar, Ravishankar Ramachandran, Kishore K Srivastava
The molecular bases of disease provide exceptional prospect to translate research findings into new drugs. Nevertheless, to develop new and novel chemical entities takes huge amount of time and efforts, mainly due to the stringent processes. Therefore, drug repurposing is one of such strategies which is being used in recent times to identify new pharmacophores. The essential first step in discovery of the specific inhibitor with low toxicity is the identification and elucidation of pathways exclusive to target pathogen...
September 16, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27454611/protein-protein-interaction-extraction-with-feature-selection-by-evaluating-contribution-levels-of-groups-consisting-of-related-features
#18
Thi Thanh Thuy Phan, Takenao Ohkawa
BACKGROUND: Protein-protein interaction (PPI) extraction from published scientific articles is one key issue in biological research due to its importance in grasping biological processes. Despite considerable advances of recent research in automatic PPI extraction from articles, demand remains to enhance the performance of the existing methods. RESULTS: Our feature-based method incorporates the strength of many kinds of diverse features, such as lexical and word context features derived from sentences, syntactic features derived from parse trees, and features using existing patterns to extract PPIs automatically from articles...
2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27429999/numerical-observer-for-atherosclerotic-plaque-classification-in-spectral-computed-tomography
#19
Auranuch Lorsakul, Georges El Fakhri, William Worstell, Jinsong Ouyang, Yothin Rakvongthai, Andrew F Laine, Quanzheng Li
Spectral computed tomography (SCT) generates better image quality than conventional computed tomography (CT). It has overcome several limitations for imaging atherosclerotic plaque. However, the literature evaluating the performance of SCT based on objective image assessment is very limited for the task of discriminating plaques. We developed a numerical-observer method and used it to assess performance on discrimination vulnerable-plaque features and compared the performance among multienergy CT (MECT), dual-energy CT (DECT), and conventional CT methods...
July 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27297359/recent-advances-in-the-development-of-sphingosine-kinase-inhibitors
#20
REVIEW
Melissa R Pitman, Maurizio Costabile, Stuart M Pitson
Sphingosine kinase (SK) 1 and 2 are lipid kinases that catalyse the formation of sphingosine 1-phosphate (S1P), a potent signalling molecule with a wide array of cellular effects. SK1 and 2 have been shown to be up-regulated in tumours and their genetic ablation or inhibition has been shown to slow tumour growth as well as sensitise cancer cells to chemotherapeutics. The SKs have been extensively studied, with a plethora of inhibitors developed that target the sphingosine-binding pocket of the enzyme, some with nanomolar affinities...
September 2016: Cellular Signalling
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