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https://www.readbyqxmd.com/read/27903597/impact-of-organic-cation-transporters-oct-slc22a-on-differential-diagnosis-of-intrahepatic-lesions
#1
Michele Visentin, Belle V van Rosmalen, Christian Hiller, Matthanja Bieze, Lia Hofstetter, Joanne Verheij, Gerd A Kullak-Ublick, Hermann Koepsell, Saffire Sks Phoa, Ikumi Tamai, Roelof J Bennink, Thomas M van Gulik, Bruno Stieger
Positron emission tomography (PET) using the cationic compound [(18)F]fluoromethylcholine (FCH) enhances the sensitivity for non-invasive classification of hepatic tumours due to peculiar patterns of accumulation. The underlying transporters are not known. We aim to identify the carriers mediating uptake of FCH in liver and to correlate their expression pattern with PET intrahepatic signal distribution to clarify the role of membrane transporters in FCH accumulation. FCH transport was characterized in cells overexpressing organic cation transporters (OCTs)...
November 30, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27858221/-preoperative-neuropathic-component-in-patients-with-back-pain
#2
Y-J Lee, E M W Koch, J B Breidebach, R Bornemann, D C Wirtz, R Pflugmacher
BACKGROUND: The objectification of pain is essential for evaluation, treatment plan and follow-up; therefore, it is necessary to find reliable clinical parameters. OBJECTIVE: The goal of the study was the preoperative screening of a neuropathic component in patients with vertebral compression fracture (WKF), herniated disc (NPP) or spinal cord compression (SKS). MATERIAL AND METHODS: Depending on the preoperative condition on admittance, patients were classified into three groups: group 1 WKF, group 2 NPP and group 3 SKS...
November 17, 2016: Der Schmerz
https://www.readbyqxmd.com/read/27753196/smith-kingsmore-syndrome-a-third-family-with-the-mtor-mutation-c-5395g-a-p-glu1799lys-and-evidence-for-paternal-gonadal-mosaicism
#3
Shahida Moosa, Helena Böhrer-Rabel, Janine Altmüller, Filippo Beleggia, Peter Nürnberg, Yun Li, Gökhan Yigit, Bernd Wollnik
Heterozygous germline mutations in MTOR have been shown to underlie Smith-Kingsmore syndrome, a rare autosomal dominant syndrome characterized by macrocephaly, developmental delay, and dysmorphic facial features. Recently, two unrelated families with the MTOR mutation, c.5395G>A p.(Glu1799Lys), were reported. Here, we describe siblings from a non-consanguineous German family in whom we identified the same heterozygous missense mutation in MTOR. Remarkably, in all reported families with Smith-Kingsmore syndrome and the MTOR c...
October 18, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27666993/cloning-expression-and-characterization-of-a-cold-adapted-shikimate-kinase-from-the-psychrophilic-bacterium-colwellia-psychrerythraea-34h
#4
Wahyu Sri Kunto Nugroho, Dong-Woo Kim, Jong-Cheol Han, Young Baek Hur, Soo-Wan Nam, Hak Jun Kim
Most cold-adapted enzymes possess higher Km and kcat values than those of their mesophilic counterparts to maximize the reaction rate. This characteristic is often ascribed to a high structural flexibility and improved dynamics in the active site. However, this may be less convincing to cold-adapted metabolic enzymes, which work at substrate concentrations near Km. In this respect, cold adaptation of a shikimate kinase (SK) in the shikimate pathway from psychrophilic Colwellia psychrerythraea (CpSK) was characterized by comparing it with a mesophilic Escherichia coli homolog (EcSK)...
September 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27512194/nodulocystic-basal-cell-carcinoma-arising-directly-from-a-seborrheic-keratosis-a-rare-case-report
#5
Kana Shibao, Naoko Okiyama, Ryota Tanaka, Hitoshi Maruyama, Yasuhiro Fujisawa, Manabu Fujimoto
Seborrheic keratoses (SKs) are common epidermal tumors composed of benign keratinocytes. Malignant skin tumors including basal cell carcinoma (BCC) rarely arise within SKs. We report a rare case of an 82-year-old man with nodulocystic BCC that appeared at the center of a scaly hyperpigmented SK that had been presented for more than 10 years. It was histologically confirmed that CK19-positive BCC arose directly from the wall of the pseudohorn cyst, a part of the SK. Nodular and/or cystic BCC also rarely arise within SKs while the most common histologic type of BCC within SKs is the superficial type...
July 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27498028/protein-kinase-c-%C3%AE-inhibitor-rottlerin-inhibits-growth-and-survival-of-mycobacteria-exclusively-through-shikimate-kinase
#6
Sapna Pandey, Aditi Chatterjee, Swati Jaiswal, Sanjay Kumar, Ravishankar Ramachandran, Kishore K Srivastava
The molecular bases of disease provide exceptional prospect to translate research findings into new drugs. Nevertheless, to develop new and novel chemical entities takes huge amount of time and efforts, mainly due to the stringent processes. Therefore, drug repurposing is one of such strategies which is being used in recent times to identify new pharmacophores. The essential first step in discovery of the specific inhibitor with low toxicity is the identification and elucidation of pathways exclusive to target pathogen...
September 16, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27454611/protein-protein-interaction-extraction-with-feature-selection-by-evaluating-contribution-levels-of-groups-consisting-of-related-features
#7
Thi Thanh Thuy Phan, Takenao Ohkawa
BACKGROUND: Protein-protein interaction (PPI) extraction from published scientific articles is one key issue in biological research due to its importance in grasping biological processes. Despite considerable advances of recent research in automatic PPI extraction from articles, demand remains to enhance the performance of the existing methods. RESULTS: Our feature-based method incorporates the strength of many kinds of diverse features, such as lexical and word context features derived from sentences, syntactic features derived from parse trees, and features using existing patterns to extract PPIs automatically from articles...
2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27429999/numerical-observer-for-atherosclerotic-plaque-classification-in-spectral-computed-tomography
#8
Auranuch Lorsakul, Georges El Fakhri, William Worstell, Jinsong Ouyang, Yothin Rakvongthai, Andrew F Laine, Quanzheng Li
Spectral computed tomography (SCT) generates better image quality than conventional computed tomography (CT). It has overcome several limitations for imaging atherosclerotic plaque. However, the literature evaluating the performance of SCT based on objective image assessment is very limited for the task of discriminating plaques. We developed a numerical-observer method and used it to assess performance on discrimination vulnerable-plaque features and compared the performance among multienergy CT (MECT), dual-energy CT (DECT), and conventional CT methods...
July 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27297359/recent-advances-in-the-development-of-sphingosine-kinase-inhibitors
#9
REVIEW
Melissa R Pitman, Maurizio Costabile, Stuart M Pitson
Sphingosine kinase (SK) 1 and 2 are lipid kinases that catalyse the formation of sphingosine 1-phosphate (S1P), a potent signalling molecule with a wide array of cellular effects. SK1 and 2 have been shown to be up-regulated in tumours and their genetic ablation or inhibition has been shown to slow tumour growth as well as sensitise cancer cells to chemotherapeutics. The SKs have been extensively studied, with a plethora of inhibitors developed that target the sphingosine-binding pocket of the enzyme, some with nanomolar affinities...
September 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27181265/targeting-multiple-response-regulators-of-mycobacterium-tuberculosis-augments-the-host-immune-response-to-infection
#10
Srijon Kaushik Banerjee, Manish Kumar, Reshma Alokam, Arun Kumar Sharma, Ayan Chatterjee, Ranjeet Kumar, Sanjaya Kumar Sahu, Kuladip Jana, Ramandeep Singh, Perumal Yogeeswari, Dharmarajan Sriram, Joyoti Basu, Manikuntala Kundu
The genome of M. tuberculosis (Mtb) encodes eleven paired two component systems (TCSs) consisting of a sensor kinase (SK) and a response regulator (RR). The SKs sense environmental signals triggering RR-dependent gene expression pathways that enable the bacterium to adapt in the host milieu. We demonstrate that a conserved motif present in the C-terminal domain regulates the DNA binding functions of the OmpR family of Mtb RRs. Molecular docking studies against this motif helped to identify two molecules with a thiazolidine scaffold capable of targeting multiple RRs, and modulating their regulons to attenuate bacterial replication in macrophages...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27119472/das-druckprofil-von-sportkompressionsstr%C3%A3-mpfen
#11
Stefanie Reich-Schupke, Stefan Surhoff, Markus Stücker
HINTERGRUND: Zunehmend werden Sportkompressionsstrümpfe (SKS) eingesetzt, doch fehlt eine Norm in Analogie zu medizinischen Kompressionsstrümpfen (MKS). Ziel dieser Pilotstudie war der Vergleich der Druckprofile von fünf SKS ex vivo und in vivo miteinander sowie mit MKS-Normen. PATIENTEN UND METHODIK: CEP Running-Progressive-Socks, Falke Running--Energizing, Sigvaris Performance, X-Socks Speed-Metal-Energizer und 2XU Compression--Race-Socks wurden an zehn Leistungssportlern (standardisiert in vivo, Kikuhime--Sensor) sowie im Hohenstein Institut (ex vivo) hinsichtlich ihres Druckprofils getestet...
May 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27059204/in-vitro-transdifferentiation-of-human-skin-keratinocytes-to-corneal-epithelial-cells
#12
Vidya Gopakumar, Nivedita Chatterjee, Sowmya Parameswaran, Subramanian Nirmala, Subramanian Krishnakumar
BACKGROUND AIMS: Skin keratinocytes (SKs) share the same surface ectodermal origin as that of corneal epithelium. In this study, the plasticity of epidermal keratinocytes was exploited to generate corneal epithelial-like cells, which might serve as an alternative source of autologous tissue for the treatment of bilateral limbal stem cell deficiency. METHODS: Skin samples were subjected to collagenase digestion to isolate SKs and transdifferentiated to corneal epithelial-like cells using limbal fibroblast conditioned medium (LFCM)...
May 2016: Cytotherapy
https://www.readbyqxmd.com/read/26927311/assessing-the-ligand-selectivity-of-sphingosine-kinases-using-molecular-dynamics-and-mm-pbsa-binding-free-energy-calculations
#13
Liang Fang, Xiaojian Wang, Meiyang Xi, Tianqi Liu, Dali Yin
The dynamic balance of sphingolipids plays a crucial role in diverse biological processes such as mitogenesis, cell migration and angiogenesis. Sphingosine kinases (SKs) including SK1 and SK2 phosphorylate sphingosine to sphingosine 1-phosphate (S1P), and control the critical balance. SK1 overexpression was reported to increase cell survival and proliferation. Although several SK1 selective inhibitors have been reported, detailed analysis toward their selectivity to understand the molecular mechanism has not been performed to our knowledge...
April 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/26886371/increased-mrna-levels-of-sphingosine-kinases-and-s1p-lyase-and-reduced-levels-of-s1p-were-observed-in-hepatocellular-carcinoma-in-association-with-poorer-differentiation-and-earlier-recurrence
#14
Baasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Kenichiro Enooku, Masaya Sato, Daisuke Saigusa, Junken Aoki, Takeaki Ishizawa, Kiyoshi Hasegawa, Norihiro Kokudo, Yutaka Yatomi
Although sphingosine 1-phosphate (S1P) has been reported to play an important role in cancer pathophysiology, little is known about S1P and hepatocellular carcinoma (HCC). To clarify the relationship between S1P and HCC, 77 patients with HCC who underwent surgical treatment were consecutively enrolled in this study. In addition, S1P and its metabolites were quantitated by LC-MS/MS. The mRNA levels of sphingosine kinases (SKs), which phosphorylate sphingosine to generate S1P, were increased in HCC tissues compared with adjacent non-HCC tissues...
2016: PloS One
https://www.readbyqxmd.com/read/26812275/unusual-dermoscopic-patterns-of-seborrheic-keratosis
#15
Lorenzo Squillace, Milena Cappello, Caterina Longo, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
BACKGROUND: Seborrheic keratoses (SKs) may sometimes mimic benign and malignant skin tumors, and a biopsy can be necessary in order to rule out malignancy. METHODS: From the database of our pigmented lesion clinic, we evaluated the dermoscopic features of difficult-to-diagnose SKs that were biopsied between January 2010 and December 2014. RESULTS: SKs represented 3.8% of all excised lesions (161/ 4,182). Specifically, 91 (56.5%) were excised to rule out melanoma, 63 (39...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26806980/author-s-reply
#16
Rajiv Thukral, Sks Marya, Chandeep Singh
No abstract text is available yet for this article.
November 2015: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/26739095/sustained-akt-activity-is-required-to-maintain-cell-viability-in-seborrheic-keratosis-a-benign-epithelial-tumor
#17
Victor A Neel, Kristina Todorova, Jun Wang, Eunjeong Kwon, Minjeong Kang, Qingsong Liu, Nathanael Gray, Sam W Lee, Anna Mandinova
Seborrheic keratoses (SKs) are common benign skin tumors that share many morphological features with their malignant counterpart, squamous cell carcinoma. SKs frequently have acquired oncogenic mutations in the receptor tyrosine kinase/phosphatidylinositol 3-kinase/Akt signaling cascade. We developed a reliable culture system to study SKs in vitro and screened these cells using a library of selective kinase inhibitors to evaluate effects on cell survival. These benign tumors are sensitive to inhibition by ATP-competitive Akt inhibitors, including A-443654 and GSK690693...
March 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26549453/coordinated-regulation-of-synaptic-plasticity-at-striatopallidal-and-striatonigral-neurons-orchestrates-motor-control
#18
Massimo Trusel, Anna Cavaccini, Marta Gritti, Barbara Greco, Pierre-Philippe Saintot, Cristiano Nazzaro, Milica Cerovic, Ilaria Morella, Riccardo Brambilla, Raffaella Tonini
The basal ganglia play a critical role in shaping motor behavior. For this function, the activity of medium spiny neurons (MSNs) of the striatonigral and striatopallidal pathways must be integrated. It remains unclear whether the activity of the two pathways is primarily coordinated by synaptic plasticity mechanisms. Using a model of Parkinson's disease, we determined the circuit and behavioral effects of concurrently regulating cell-type-specific forms of corticostriatal long-term synaptic depression (LTD) by inhibiting small-conductance Ca(2+)-activated K(+) channels (SKs) of the dorsolateral striatum...
November 17, 2015: Cell Reports
https://www.readbyqxmd.com/read/26249354/structure-of-shikimate-kinase-an-in-vivo-essential-metabolic-enzyme-in-the-nosocomial-pathogen-acinetobacter-baumannii-in-complex-with-shikimate
#19
Kristin A Sutton, Jennifer Breen, Ulrike MacDonald, Janet M Beanan, Ruth Olson, Thomas A Russo, L Wayne Schultz, Timothy C Umland
Acinetobacter baumannii is an opportunistic Gram-negative pathogen that is an important cause of healthcare-associated infections exhibiting high mortality rates. Clinical isolates of multidrug-resistant (MDR) and extremely drug-resistant (XDR) A. baumannii strains are increasingly being observed. Compounding this concern is the dearth of new antibacterial agents in late-stage development that are effective against MDR and XDR A. baumannii. As part of an effort to address these concerns, two genes (aroA and aroC) of the shikimate pathway have previously been determined to be essential for the growth and survival of A...
August 2015: Acta Crystallographica. Section D, Biological Crystallography
https://www.readbyqxmd.com/read/26166566/ube3a-regulates-synaptic-plasticity-and-learning-and-memory-by-controlling-sk2-channel-endocytosis
#20
Jiandong Sun, Guoqi Zhu, Yan Liu, Steve Standley, Angela Ji, Rashmi Tunuguntla, Yubin Wang, Chad Claus, Yun Luo, Michel Baudry, Xiaoning Bi
Gated solely by activity-induced changes in intracellular calcium, small-conductance potassium channels (SKs) are critical for a variety of functions in the CNS, from learning and memory to rhythmic activity and sleep. While there is a wealth of information on SK2 gating, kinetics, and Ca(2+) sensitivity, little is known regarding the regulation of SK2 subcellular localization. We report here that synaptic SK2 levels are regulated by the E3 ubiquitin ligase UBE3A, whose deficiency results in Angelman syndrome and overexpression in increased risk of autistic spectrum disorder...
July 21, 2015: Cell Reports
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