L Incorvaia, G Badalamenti, G Novo, S Gori, L Cortesi, C Brando, S Cinieri, G Curigliano, G R Ricciardi, A Toss, R Chiari, R Berardi, Z Ballatore, M Bono, T D Bazan Russo, V Gristina, A Galvano, G Damerino, L Blasi, V Bazan, A Russo
BACKGROUND: The BRCA proteins play a key role in the homologous recombination (HR) pathway. Beyond BRCA1/2, other genes are involved in the HR repair (HRR). Due to the prominent role in the cellular repair process, pathogenic or likely pathogenic variants (PV/LPVs) in HRR genes may cause inadequate DNA damage repair in cardiomyocytes. PATIENTS AND METHODS: This was a multicenter, hospital-based, retrospective cohort study to investigate the heart toxicity from anthracycline-containing regimens (ACRs) in the adjuvant setting of breast cancer (BC) patients carrying germline BRCA PV/LPVs and no-BRCA HRR pathway genes...
January 2024: ESMO Open