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https://www.readbyqxmd.com/read/29327847/the-role-of-science-in-the-opioid-crisis
#1
Nora D Volkow, Francis S Collins
No abstract text is available yet for this article.
November 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29318488/disrupted-topological-organization-of-the-frontal-mesolimbic-network-in-obese-patients
#2
Qianqian Meng, Yu Han, Gang Ji, Guanya Li, Yang Hu, Li Liu, Qingchao Jin, Karen M von Deneen, Jizheng Zhao, Guangbin Cui, Huaning Wang, Dardo Tomasi, Nora D Volkow, Jixin Liu, Yongzhan Nie, Yi Zhang, Gene-Jack Wang
Neuroimaging studies have revealed brain functional abnormalities in frontal-mesolimbic regions in obesity. However, the effects of obesity on brain network topology remains largely unknown. In the current study, we employed resting-state functional magnetic resonance imaging and graph theory methods to investigate obesity-related changes in brain network topology in 26 obese patients and 28 normal weight subjects. Results revealed that the whole-brain networks of the two groups exhibited typical features of small-world topology...
January 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29307014/stenotrophomonas-maltophilia-bacteremia-and-pneumonia-at-a-tertiary-care-oncology-center-a-review-of-16%C3%A2-years
#3
Consuelo Velázquez-Acosta, Sugehily Zarco-Márquez, Mari Carmen Jiménez-Andrade, Patricia Volkow-Fernández, Patricia Cornejo-Juárez
PURPOSE: The aim of this study was to describe the clinical characteristics and antimicrobial patterns of Stenotrophomonas maltophilia bloodstream infections (BSI) and pneumonia episodes in patients with cancer. METHODS: Patients with S. maltophilia BSI or pneumonia admitted from 1 Jan. 2000 to 31 Dec. 2016 were identified at the Instituto Nacional de Cancerología (INCan), a tertiary-care oncology hospital in Mexico City. RESULTS: During the study period, there were 171 isolates identified...
January 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29300843/reduced-local-and-increased-long-range-functional-connectivity-of-the-thalamus-in-autism-spectrum-disorder
#4
Dardo Tomasi, Nora D Volkow
It is hypothesized that brain network abnormalities in autism spectrum disorder (ASD) reflect local overconnectivity and long-range underconnectivity. However, this is not a consistent finding in recent studies, which could reflect the developmental nature and the heterogeneity of ASD. Here, we tested 565 ASD and 602 neurotypical (NT) males, and 91 ASD and 233 NT females using local functional connectivity density (lFCD) mapping and seed-voxel correlation analyses to assess how local and long-range connectivities differ in ASD...
December 29, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29283486/toward-precision-medicine-in-addiction-treatment
#5
Nora Volkow
No abstract text is available yet for this article.
January 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29225975/correlation-between-traits-of-emotion-based-impulsivity-and-intrinsic-default-mode-network-activity
#6
Jizheng Zhao, Dardo Tomasi, Corinde E Wiers, Ehsan Shokri-Kojori, Şükrü B Demiral, Yi Zhang, Nora D Volkow, Gene-Jack Wang
Negative urgency (NU) and positive urgency (PU) are implicated in several high-risk behaviors, such as eating disorders, substance use disorders, and nonsuicidal self-injury behavior. The current study aimed to explore the possible link between trait of urgency and brain activity at rest. We assessed the amplitude of low-frequency fluctuations (ALFF) of the resting-state functional magnetic resonance imaging (fMRI) signal in 85 healthy volunteers. Trait urgency measures were related to ALFF in the lateral orbitofrontal cortex, dorsolateral prefrontal cortex, ventral and dorsal medial frontal cortex, anterior cingulate, and posterior cingulate cortex/precuneus...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29160944/ketogenic-diet-suppresses-alcohol-withdrawal-syndrome-in-rats
#7
Ditte Dencker, Anna Molander, Morgane Thomsen, Chantal Schlumberger, Gitta Wortwein, Pia Weikop, Helene Benveniste, Nora D Volkow, Anders Fink-Jensen
BACKGROUND: Alcohol use disorder is under-diagnosed and under-treated, and up to 50% of alcohol abstinent patients diagnosed with alcohol dependence relapse within the first year of treatment. Current treatments for the maintenance of alcohol abstinence in patients with alcohol use disorder have limited efficacy, and there is an urgent need for novel treatment strategies. Decreased cerebral glucose metabolism and increased brain uptake of acetate was recently reported in heavy drinkers, relative to controls...
November 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29150199/medications-for-opioid-use-disorder-bridging-the-gap-in-care
#8
Nora D Volkow
No abstract text is available yet for this article.
November 14, 2017: Lancet
https://www.readbyqxmd.com/read/29142296/the-dopamine-motive-system-implications-for-drug-and-food-addiction
#9
REVIEW
Nora D Volkow, Roy A Wise, Ruben Baler
Behaviours such as eating, copulating, defending oneself or taking addictive drugs begin with a motivation to initiate the behaviour. Both this motivational drive and the behaviours that follow are influenced by past and present experience with the reinforcing stimuli (such as drugs or energy-rich foods) that increase the likelihood and/or strength of the behavioural response (such as drug taking or overeating). At a cellular and circuit level, motivational drive is dependent on the concentration of extrasynaptic dopamine present in specific brain areas such as the striatum...
November 16, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29112197/association-of-genetic-ancestry-with-striatal-dopamine-d2-d3-receptor-availability
#10
C E Wiers, P C Towb, C A Hodgkinson, P-H Shen, C Freeman, G Miller, E Lindgren, E Shokri-Kojori, Ş B Demiral, S W Kim, D Tomasi, H Sun, G-J Wang, D Goldman, N D Volkow
Despite ethnic differences in allele frequencies of variants in dopaminergic genes associated with dopamine D2/D3 receptor availability (D2R), no study to date has investigated the relationship between genetic ancestry and striatal D2R. Here, we show that ancestry-informative markers significantly predict dorsal striatal D2R in 117 healthy ethnically diverse residents of the New York metropolitan area using Positron Emission Tomography (PET) with [(11)C]raclopride (P<0.0001), while correcting for age, sex, BMI, education, smoking status, and estimated socioeconomic status (ZIP codes)...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29081530/nora-volkow
#11
(no author information available yet)
No abstract text is available yet for this article.
October 30, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29051027/the-conception-of-the-abcd-study-from-substance-use-to-a-broad-nih-collaboration
#12
REVIEW
Nora D Volkow, George F Koob, Robert T Croyle, Diana W Bianchi, Joshua A Gordon, Walter J Koroshetz, Eliseo J Pérez-Stable, William T Riley, Michele H Bloch, Kevin Conway, Bethany G Deeds, Gayathri J Dowling, Steven Grant, Katia D Howlett, John A Matochik, Glen D Morgan, Margaret M Murray, Antonio Noronha, Catherine Y Spong, Eric M Wargo, Kenneth R Warren, Susan R B Weiss
Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use. However, there is much we have yet to learn about how these experiences influence brain development, how they promote or interfere with later health outcomes, or even what healthy brain development looks like. A large longitudinal study beginning in early adolescence could help us understand the normal variability in adolescent brain and cognitive development and tease apart the many factors that influence it...
October 10, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29029586/use-and-misuse-of-opioids-in-chronic-pain
#13
Nora Volkow, Helene Benveniste, A Thomas McLellan
The prescribing of opioid analgesics for pain management-particularly for management of chronic noncancer pain (CNCP)-has increased more than fourfold in the United States since the mid-1990s. Yet there is mounting evidence that opioids have only limited effectiveness in the management of CNCP, and the increased availability of prescribed opioids has contributed to upsurges in opioid-related addiction cases and overdose deaths. These concerns have led to critical revisiting and modification of prior pain management practices (e...
October 13, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28979253/rapid-gene-turnover-as-a-significant-source-of-genetic-variation-in-a-recently-seeded-population-of-a-healthcare-associated-pathogen
#14
Lucía Graña-Miraglia, Luis F Lozano, Consuelo Velázquez, Patricia Volkow-Fernández, Ángeles Pérez-Oseguera, Miguel A Cevallos, Santiago Castillo-Ramírez
Genome sequencing has been useful to gain an understanding of bacterial evolution. It has been used for studying the phylogeography and/or the impact of mutation and recombination on bacterial populations. However, it has rarely been used to study gene turnover at microevolutionary scales. Here, we sequenced Mexican strains of the human pathogen Acinetobacter baumannii sampled from the same locale over a 3 year period to obtain insights into the microevolutionary dynamics of gene content variability. We found that the Mexican A...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28974452/long-term-optical-imaging-of-neurovascular-coupling-in-mouse-cortex-using-gcamp6f-and-intrinsic-hemodynamic-signals
#15
Xiaochun Gu, Wei Chen, Jiang You, Alan P Koretsky, N D Volkow, Yingtian Pan, Congwu Du
Cerebral hemodynamics are modulated in response to changes in neuronal activity, a process termed neurovascular coupling (NVC), which can be disrupted by neuropsychiatric diseases (e.g., stroke, Alzheimer's disease). Thus, there is growing interest to image long-term NVC dynamics with high spatiotemporal resolutions. Here, by combining the use of a genetically-encoded calcium indicator with optical techniques, we develop a longitudinal multimodal optical imaging platform (MIP) that enabled time-lapse tracking of NVC over a relatively large field of view in the mouse somatosensory cortex at single cell and single vessel resolutions...
January 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/28930574/food-addiction-a-common-neurobiological-mechanism-with-drug-abuse
#16
Elsa Lindgren, Kyle Gray, Gregg Miller, Ryan Tyler, Corinde E Wiers, Nora D Volkow, Gene-Jack Wang
Drugs and food both exert a rewarding effect through the firing of dopamine neurons in the ventral tegmental area, resulting in the release of dopamine into the nucleus accumbens and effects on the mesolimbic pathway. Here, we review the neuroimaging literature to consider the validity of food addiction and the common neurobiological mechanisms that overlap in food and drug addiction. This review paper focuses on findings from Positron Emission Tomography (PET), functional Magnetic Resonance Imaging (fMRI) and structural imaging studies, as well as evidence from neuroimaging studies of bariatric surgery and pharmacological interventions on obese individuals...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28918267/compulsivity-in-opioid-dependence
#17
Serenella Tolomeo, Keith Matthews, Douglas Steele, Alex Baldacchino
OBJECTIVE: This study aimed to investigate the relationship between compulsivity versus impulsivity and structural MRI abnormalities in opioid dependence. METHOD: We recruited 146 participants: i) patients with a history of opioid dependence due to chronic heroin use (n=24), ii) heroin users stabilised on methadone maintenance treatment (n=48), iii) abstinent participants with a history of opioid dependence due to heroin use (n=24) and iv) healthy controls (n=50)...
September 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28736021/infectious-complications-and-multidrug-resistant-bacteria-in-patients-with-hematopoietic-stem-cell-transplantation-in-the-first-12-months-after-transplant
#18
A César-Arce, P Volkow-Fernández, L M Valero-Saldaña, B Acosta-Maldonado, D Vilar-Compte, P Cornejo-Juárez
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) has been used as treatment in different hematologic and solid malignancies. The aim of this study was to describe the frequency of infectious complications, microbiology, and outcome in patients undergoing HSCT in Mexico during the pre-engraftment period and the impact on mortality rates at 12 months. METHODS: We conducted a retrospective study of all hematologic malignancies that received HSCT from January 2009 and December 2014, at an oncology reference center...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28731033/linking-brain-connectivity-and-behavior-after-acute-and-chronic-alcohol-exposure
#19
E Shokri-Kojori, D Tomasi, C E Wiers, G-J Wang, N D Volkow
No abstract text is available yet for this article.
August 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28682879/sociodemographic-differences-among-hiv-positive-and-hiv-negative-recently-pregnant-women-in-mexico-city-a-case-control-study
#20
Daniel Aguilar-Zapata, Alicia Piñeirúa-Menéndez, Patricia Volkow-Fernández, Patricia Rodríguez-Zulueta, Ubaldo Ramos-Alamillo, Teresita Cabrera-López, Alexandra Martin-Onraet
National HIV preventive programs in Mexico focus on high-risk groups that do not consider women, apart from prenatal screening. Nonetheless, the epidemic in women is growing, and there is a need to better understand sociodemographic factors in women living with HIV (WLH). We performed a case-control study in Mexico City, including HIV+ and HIV- women with a recent pregnancy to compare their sociodemographic characteristics and describe the circumstances of diagnosis in HIV+ women, as well as prenatal screening frequency in both groups...
July 2017: Medicine (Baltimore)
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