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https://www.readbyqxmd.com/read/25848464/diagnosis-and-treatment-of-hepatocellular-carcinoma-an-update
#1
REVIEW
Javier Tejeda-Maldonado, Ignacio García-Juárez, Jonathan Aguirre-Valadez, Adrián González-Aguirre, Mario Vilatobá-Chapa, Alejandra Armengol-Alonso, Francisco Escobar-Penagos, Aldo Torre, Juan Francisco Sánchez-Ávila, Diego Luis Carrillo-Pérez
Hepatocellular carcinoma (HCC) is one of the most common malignancies leading to high mortality rates in the general population; in cirrhotic patients, it is the primary cause of death. The diagnosis is usually delayed in spite of at-risk population screening recommendations, i.e., patients infected with hepatitis B or C virus. Hepatocarcinogenesis hinges on a great number of genetic and molecular abnormalities that lead to tumor angiogenesis and foster their dissemination potential. The diagnosis is mainly based on imaging studies such as computed tomography and magnetic resonance, in which lesions present a characteristic classical pattern of early arterial enhancement followed by contrast medium "washout" in late venous phase...
March 27, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/25776057/ipathology-cockpit-diagnostic-station-validation-according-to-college-of-american-pathologists-pathology-and-laboratory-quality-center-recommendation-at-the-hospital-trust-and-university-of-verona
#2
Matteo Brunelli, Serena Beccari, Romano Colombari, Stefano Gobbo, Luca Giobelli, Andrea Pellegrini, Marco Chilosi, Maria Lunardi, Guido Martignoni, Aldo Scarpa, Albino Eccher
BACKGROUND: Validation of digital whole slide images is crucial to ensure that diagnostic performance is at least equivalent to that of glass slides and light microscopy. The College of American Pathologists Pathology and Laboratory Quality Center recently developed recommendations for internal digital pathology system validation. Following these guidelines we sought to validate the performance of a digital approach for routine diagnosis by using an iPad and digital control widescreen-assisted workstation through a pilot study...
December 2014: Diagnostic Pathology
https://www.readbyqxmd.com/read/25654085/hfe-genotyping-in-patients-with-elevated-serum-iron-indices-and-liver-diseases
#3
Andreia Silva Evangelista, Maria Cristina Nakhle, Thiago Ferreira de Araújo, Clarice Pires Abrantes-Lemos, Marta Mitiko Deguti, Flair José Carrilho, Eduardo Luiz Rachid Cançado
Iron abnormalities in chronic liver disease may be the result of genetic diseases or secondary factors. The present study aimed to identify subjects with HFE-HH in order to describe the frequency of clinical manifestations, identify risk factors for iron elevation, and compare the iron profile of HFE-HH to other genotypes in liver disease patients. A total of 108 individuals with hepatic disease, transferrin saturation (TS) > 45%, and serum ferritin (SF) > 350 ng/mL were tested for HFE mutations. Two groups were characterized: C282Y/C282Y or C282Y/H63D genotypes (n = 16) were the HFE hereditary hemochromatosis (HFE-HH) group; and C282Y and H63D single heterozygotes, the H63D/H63D genotype, and wild-type were considered group 2 (n = 92)...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25565219/ipathology-cockpit-diagnostic-station-validation-according-to-college-of-american-pathologists-pathology-and-laboratory-quality-center-recommendation-at-the-hospital-trust-and-university-of-verona
#4
Matteo Brunelli, Serena Beccari, Romano Colombari, Stefano Gobbo, Luca Giobelli, Andrea Pellegrini, Marco Chilosi, Maria Lunardi, Guido Martignoni, Aldo Scarpa, Albino Eccher
BACKGROUND: Validation of digital whole slide images is crucial to ensure that diagnostic performance is at least equivalent to that of glass slides and light microscopy. The College of American Pathologists Pathology and Laboratory Quality Center recently developed recommendations for internal digital pathology system validation. Following these guidelines we sought to validate the performance of a digital approach for routine diagnosis by using an iPad and digital control widescreen-assisted workstation through a pilot study...
2014: Diagnostic Pathology
https://www.readbyqxmd.com/read/25418594/-hiv-related-malignancies-state-of-art
#5
REVIEW
Aurélien Gobert, Nicolas Mounier, Armelle Lavole, Isabelle Poizot-Martin, Jean-Philippe Spano
HIV infection is related to an increased risk of cancer compared with general population, both AIDS-defining cancers (Kaposi's sarcoma, non Hodgkin's lymphoma, invasive cervical cancer) and non-AIDS-defining cancers. Although the advent of the highly active antiretroviral therapy era has decreased the Kaposi's sarcoma and non-Hodgkin's lymphoma incidences, non-AIDS-defining malignancies, such as lung cancer, hepatocarcinoma, anal cancer and skin cancers, remain a major cause of morbidity and death in the HIV-infected population...
November 2014: Bulletin du Cancer
https://www.readbyqxmd.com/read/22741810/treatment-of-recurrent-hepatocellular-carcinoma-with-sorafenib-in-a-hiv-hcv-co-infected-patient-in-haart-a-case-report
#6
Pasquale De Nardo, Magdalena Viscione, Angela Corpolongo, Rita Bellagamba, Giovanni Vennarecci, Giuseppe Maria Ettorre, Elisa Gentilotti, Chiara Tommasi, Emanuele Nicastri
UNLABELLED: HASH(0x51401a8) BACKGROUND: Liver disease is the second cause of death among HIV patients receiving highly active antiretroviral therapy (HAART) in Europe. HIV patients have a high prevalence of chronic HBV (6-10%) and HCV (33%) co-infection, and accelerated progression of viral hepatitis. Furthermore, the long duration of both HIV and HCV diseases in the HAART era increases the risk of hepatocellular carcinoma. FINDINGS: We report the case of a 49 year -old HIV/HCV co-infected male patient who developed hepatocellular carcinoma...
2012: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/22265375/-retrospective-study-of-risk-factors-of-vertical-transmission-of-hepatitis-c-virus
#7
P Madurga Revilla, M Aguar Carrascosa, A Pereda Pérez, V Modesto Alapont, A Montañés Sánchez, E Torres Martínez, M Brugada Montanter, S León Cariñena
INTRODUCTION: Despite the low prevalence of paediatric HCV infection and its initial mild clinical expressiveness, chronic infection could progress into cirrhosis and/or hepatocarcinoma. It is essential to control vertical transmission. Recent studies show that up to 50% of transmissions occur within the uterus. MATERIAL AND METHODS: [corrected] A retrospective study was conducted on 17 cases of (Hepatitis C virus) HCV infection registered over a period of 8 years...
June 2012: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/21703723/-cost-of-screening-for-hepatocarcinoma-in-patients-with-cirrhosis-a-prospective-study
#8
Pau Sort, Marco Antonio Alvarez, Anna Bargalló, Alvaro Isava, María Muñoz, Francesc Porta, Eva Rodríguez, Francesc Vida
INTRODUCTION: Current clinical guidelines recommend biannual screening for hepatocarcinoma in cirrhotic patients; however, the cost of this preventive activity is unknown. OBJECTIVE: To determine the cost of ultrasound screening for hepatocarcinoma in patients with cirrhosis. PATIENTS AND METHOD: Data on patients diagnosed with liver cirrhosis in a population of 245,042 inhabitants were prospectively gathered. The screening tests performed and cases of hepatocarcinoma diagnosed during the annual follow-up were included in the analysis...
October 2011: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/20714000/clinical-approach-to-the-patient-with-chronic-hepatitis-c-infection-and-normal-aminotransferases
#9
Rodrigo Zapata
Approximately 30% of patients with chronic HCV infection have persistently normal alanine aminotransferase levels (PNALT). Most of these patients have minimal or mild inflammation and absent or minimal fibrosis, although occasionally cirrhosis and hepatocarcinoma may be seen. Overall, liver histology is significantly less severe than in patients with elevated ALT levels, and most follow-up studies have reported stability of the disease, with minimal fibrosis progression over years, and thus a disease with a favorable prognosis...
2010: Annals of Hepatology
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