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https://www.readbyqxmd.com/read/29471464/poor-immunogenicity-not-vaccine-strain-egg-adaptation-may-explain-the-low-h3n2-influenza-vaccine-effectiveness-in-2012-13
#1
Sarah Cobey, Sigrid Gouma, Kaela Parkhouse, Benjamin S Chambers, Hildegund C Ertl, Kenneth E Schmader, Rebecca A Halpin, Xudong Lin, Timothy B Stockwell, Suman R Das, Emily Landon, Vera Tesic, Ilan Youngster, Benjamin A Pinsky, David E Wentworth, Scott E Hensley, Yonatan H Grad
Background: Influenza vaccination aims to prevent infection by influenza virus and reduce associated morbidity and mortality; however, vaccine effectiveness (VE) can be modest, especially for subtype A(H3N2). Low VE has been attributed to mismatches between the vaccine and circulating influenza strains and to the vaccine's elicitation of protective immunity in only a subset of the population. The low H3N2 VE in the 2012-2013 season was attributed to egg-adaptive mutations that created antigenic mismatch between the actual vaccine strain (IVR-165) and both the intended vaccine strain (A/Victoria/361/2011) and the predominant circulating strains (clades 3C...
February 20, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471137/mucosal-and-systemic-responses-of-immunogenic-vaccines-candidates-against-enteric-escherichia-coli-infections-in-ruminants-a-review
#2
REVIEW
A Lawan, F F A Jesse, U H Idris, M N Odhah, M Arsalan, N A Muhammad, K R Bhutto, Innocent Damudu Peter, G A Abraham, A H Wahid, M L Mohd-Azmi, M Zamri-Saad
Innumerable Escherichia coli of animal origin are identified, which are of economic significance, likewise, cattle, sheep and goats are the carrier of enterohaemorrhagic E. coli, which are less pathogenic, and can spread to people by way of direct contact and through the contamination of foodstuff or portable drinking water, causing serious illness. The immunization of ruminants has been carried out for ages and is largely acknowledged as the most economical and maintainable process of monitoring E. coli infection in ruminants...
February 19, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29470934/bivalent-oral-cholera-vaccine-in-participants-aged-1-year-and-older-in-the-dominican-republic-a-phase-iii-single-arm-safety-and-immunogenicity-trial
#3
Lina Cordero De Los Santos, Jesús Feris-Iglesias, Naveena Aloysia D'Cor, Venkata Jayanth Midde, Badri Narayan Patnaik, Yaël Thollot, Anvar Rasuli, Eric Desauziers
The Dominican Republic, historically non-endemic for cholera, is experiencing an ongoing cholera epidemic. We assessed the safety and immunogenicity of two doses of the killed bivalent (O1 and O139) whole-cell oral cholera vaccine (OCV) on day (D)0 and D14 in healthy participants aged ≥1 year. Immediate unsolicited systemic adverse events (AEs) were monitored up to 30 minutes and solicited systemic reactions, up to 7 days after each vaccination. Unsolicited AEs were recorded up to D14 (post-dose 1) and 30 days post-dose 2...
February 22, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29467889/serum-immunoglobulin-e-response-as-a-marker-for-unfavorable-prognosis-following-cholesteryl-pullulan-mage-a4-vaccination
#4
Takehiro Abiko, Takahiro Tsuchikawa, Kengo Miyauchi, Masataka Wada, Noriaki Kyogoku, Toshiaki Shichinohe, Yoshihiro Miyahara, Shinichi Kageyama, Hiroaki Ikeda, Hiroshi Shiku, Satoshi Hirano
Since 2009, a cancer vaccine clinical trial was conducted with melanoma antigen gene-A4 as an immunogenic agent. The levels of IgG1, IgG2 and IgG3, which are known to be Type 1 T helper cell-associated antibodies, and the levels of IgG4 and IgE, which are known to be Type 2 T helper cell-associated antibodies, were measured and used as biomarkers for predicting therapeutic effect. The results of the present study indicated a strong positive correlation between IgG2 and IgG4, with a correlation coefficient of R=0...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467764/-propionibacterium-acnes-enhances-the-immunogenicity-of-hivbr18-human-immunodeficiency-virus-1-vaccine
#5
Daniela Teixeira, Mayari Eika Ishimura, Juliana de Souza Apostólico, Jacqueline Miyuki Viel, Victor Cabelho Passarelli, Edecio Cunha-Neto, Daniela Santoro Rosa, Ieda Maria Longo-Maugéri
Immunization of BALB/c mice with HIVBr18, a DNA vaccine containing 18 CD4+ T cell epitopes from human immunodeficiency virus (HIV), induced specific CD4+ and CD8+ T cell responses in a broad, polyfunctional and persistent manner. With the aim of increasing the immunogenicity of this vaccine, the effect of Propionibacterium acnes as an adjuvant was evaluated. The adjuvant effects of this bacterium have been extensively demonstrated in both experimental and clinical settings. Herein, administration of two doses of HIVBr18, in the presence of P...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467445/vaccine-induced-antigen-specific-regulatory-t-cells-attenuate-the-antiviral-immunity-against-acute-influenza-virus-infection
#6
Pin-Hung Lin, Weng-In Wong, Yi-Lan Wang, Meng-Ping Hsieh, Chia-Wen Lu, Chieh-Yu Liang, Sung-Hsiang Jui, Fang-Yi Wu, Pei-Jer Chen, Hung-Chih Yang
Peptide-based T cell vaccines targeting the conserved epitopes of influenza virus can provide cross-protection against distantly related strains, but they are generally not immunogenic. Foreign antigen-specific regulatory T (Treg) cells are induced under subimmunogenic conditions peripherally, although their development and role in vaccine-mediated antiviral immunity is unclear. Here, we demonstrated primary vaccination with peptides alone significantly induced antigen-specific Foxp3+ Treg cells, which were further expanded by repeated vaccination with unadjuvanted peptides...
February 21, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29467399/assessment-of-novel-vaccination-regimens-using-viral-vectored-liver-stage-malaria-vaccines-encoding-me-trap
#7
Carly M Bliss, Georgina Bowyer, Nicholas A Anagnostou, Tom Havelock, Claudia M Snudden, Huw Davies, Simone C de Cassan, Amy Grobbelaar, Alison M Lawrie, Navin Venkatraman, Ian D Poulton, Rachel Roberts, Pooja B Mange, Prateek Choudhary, Saul N Faust, Stefano Colloca, Sarah C Gilbert, Alfredo Nicosia, Adrian V S Hill, Katie J Ewer
Heterologous prime-boost vaccination with viral vectors simian adenovirus 63 (ChAd63) and Modified Vaccinia Ankara (MVA) induces potent T cell and antibody responses in humans. The 8-week regimen demonstrates significant efficacy against malaria when expressing the pre-erythrocytic malaria antigen Thrombospondin-Related Adhesion Protein fused to a multiple epitope string (ME-TRAP). We tested these vaccines in 7 new 4- and 8- week interval schedules to evaluate safety and immunogenicity of multiple ChAd63 ME-TRAP priming vaccinations (denoted A), multiple MVA ME-TRAP boosts (denoted M) and alternating vectors...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467018/efficacy-of-different-dna-and-mva-prime-boost-vaccination-regimens-against-a-rift-valley-fever-virus-rvfv-challenge-in-sheep-12-weeks-following-vaccination
#8
Gema Lorenzo, Elena López-Gil, Javier Ortego, Alejandro Brun
The aim of this work was to evaluate the immunogenicity and efficacy of DNA and MVA vaccines encoding the RVFV glycoproteins Gn and Gc in an ovine model of RVFV infection. Adult sheep of both sexes were challenged 12 weeks after the last immunization and clinical, virological, biochemical and immunological consequences, were analyzed. Strategies based on immunization with homologous DNA or heterologous DNA/MVA prime-boost were able to induce a rapid in vitro neutralizing antibody response as well as IFNγ production after in vitro virus specific re-stimulation...
February 21, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29466034/astragalus-saponins-and-liposome-constitute-an-efficacious-adjuvant-formulation-for-cancer-vaccines
#9
Xiao-Ping Zhang, Ying-Dong Li, Lu-Lu Luo, Yong-Qi Liu, Yang Li, Chao Guo, Zhen-Dong Li, Xiao-Rong Xie, Hai-Xia Song, Li-Ping Yang, Shao-Bo Sun, Fang-Yu An
Cancer vaccines mostly aim to induce cytotoxic T lymphocytes (CTLs) against tumors. An appropriate adjuvant is of fundamental importance for inducing cellular immune response. Since the antigen in particulate form is substantially more immunogenic than soluble form antigen, it is beneficial to interact with antigen-presenting cells membrane to induce robust CD8+ T cell activation following vaccination. Based on previous research, we designed an adjuvant formulation by combining Astragalus saponins, cholesterol, and liposome to incorporate antigen into a particulate delivery system, so as to enhance cellular immune response...
February 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29465480/impact-of-fever-and-antipyretic-use-on-influenza-vaccine-immune-reponses-in-children
#10
Jean Li-Kim-Moy, Nicholas Wood, Cheryl Jones, Kristine Macartney, Robert Booy
BACKGROUND: Comparing post-vaccination fever rates in pediatric influenza vaccine clinical trials is difficult due to variability in how fever is reported. The impact of vaccine-related fever and antipyretic use on trivalent influenza vaccine (TIV) immunogenicity in children is also unclear. METHODS: In this pilot study, we obtained individual-level data provided by GlaxoSmithKline (GSK) from three pediatric clinical trials of GSK versus comparator TIV. We explored a primary study (NCT00764790), the largest trial involving young children (6-35 months, n=3317), and further explored key findings in the two other trials (3-17 years, NCT00980005; 6m-17y NCT00383123)...
February 19, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29462947/immunogenic-apoptosis-as-a-novel-tool-for-anticancer-vaccine-development
#11
REVIEW
Barbara Montico, Annunziata Nigro, Vincenzo Casolaro, Jessica Dal Col
Immunogenic apoptosis, or more appropriately called immunogenic cell death (ICD), is a recently described form of apoptosis induced by a specific set of chemotherapeutic drugs or by physical therapeutic modalities, such as ionizing irradiation and photodynamic therapy. The peculiar characteristic of ICD is the ability to favor recognition and elimination of dying tumor cells by phagocytes in association with the release of pro-inflammatory molecules (such as cytokines and high-mobility group box-1). While in vitro and animal models pointed to ICD as one of the molecular mechanisms mediating the clinical efficacy of some anticancer agents, it is hard to clearly demonstrate its contribution in cancer patients...
February 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29462200/a-prophylactic-multivalent-vaccine-against-different-filovirus-species-is-immunogenic-and-provides-protection-from-lethal-infections-with-ebolavirus-and-marburgvirus-species-in-non-human-primates
#12
Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn
The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections. A good prophylactic vaccine should be able to provide protection to all known filovirus species and as an upside potentially protect from newly emerging virus strains. We investigated the immunogenicity and protection elicited by multivalent vaccines expressing glycoproteins (GP) from Ebola virus (EBOV), Sudan virus (SUDV), Taï Forest virus (TAFV) and Marburg virus (MARV)...
2018: PloS One
https://www.readbyqxmd.com/read/29461919/persistence-of-immune-response-to-an-adjuvanted-varicella-zoster-virus-subunit-vaccine-for-up-to-year-nine-in-older-adults
#13
Tino F Schwarz, Stephanie Volpe, Gregory Catteau, Roman Chlibek, Marie Pierre David, Jan Hendrik Richardus, Himal Lal, Lidia Oostvogels, Karlis Pauksens, Stephanie Ravault, Lars Rombo, Gerard Sonder, Jan Smetana, Thomas Heineman, Adriana Bastidas
BACKGROUND: In adults aged ≥60 years, two doses of the herpes zoster subunit vaccine (HZ/su; 50µg varicella-zoster virus glycoprotein E [gE] and AS01B Adjuvant System) elicited humoral and cell-mediated immune responses persisting for at least six years. We assessed immunogenicity nine years post-initial vaccination. METHODS: This open extension study (NCT02735915) followed 70 participants who received two HZ/su doses in the initial trial (NCT00434577). Blood samples to assess the cellular (intracellular cytokine staining) and humoral (ELISA) immunity were taken at year nine post-initial vaccination...
February 20, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29461913/immunogenicity-and-safety-of-the-first-indigenously-developed-indian-tetravalent-influenza-vaccine-split-virion-in-healthy-adults-%C3%A2-18-years-of-age-a-randomized-multicenter-phase-ii-iii-clinical-trial
#14
Shrikant Sharma, Veer Bahadur Singh, Sanjay Kumar, Vipul Prajapati, Jitendra Patel, Rajesh Vukkala, Sanjay Kumar Jangid, Jayesh Sanmukhani, Gaurav Gupta, Pradip Patel, Ravindra Mittal, Reinhard Glueck
This phase II / III clinical trial was conducted to evaluate the immunogenicity and safety of the Tetravalent Influenza vaccine (Split virion) I.P. (TetIV) developed indigenously in the country for the first time by M/s Cadila Healthcare Limited, India containing two influenza A and two influenza B strains, one of each, Yamagata (B/Phuket) and Victoria (B/Brisbane) lineage and also compare it to that of an licensed seasonal Trivalent Influenza vaccine (TriIV) of Sanofi Pasteur India Private Limited, containing the two influenza A and only the Yamagata lineage (B/Phuket) strain...
February 20, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29460861/immunogenicity-of-ompa-and-ompb-antigens-from-rickettsia-rickettsii-on-mononuclear-cells-from-rickettsia-positive-mexican-patients
#15
Dzul-Rosado Karla, Balam-Romero Javier, Valencia-Pacheco Guillermo, Lugo-Caballero Cesar, Arias-Leon Juan Jose, Peniche-Lara Gaspar, Zavala-Castro Jorge
Background & objectives: The nature of the rickettsial antigens and the immune response generated by them, have been the subject of exhaustive research so that a suitable vaccine can be developed. Till date evaluations of Rickettsia rickettsii antigens that induce both humoral and cellular responses in animal models have only shown partial protection and short-term immunological memory. This study was aimed to evaluate the immune response induced by DNA plasmids generated from the OmpA and OmpB genes of R...
October 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29460309/entrapment-of-ltb-protein-in-alginate-nanoparticles-protects-against-enterotoxigenic-escherichia-coli
#16
Emad Kordbacheh, Shahram Nazarian, Abbas Hajizadeh, Davood Sadeghi
Vaccine delivery vehicles are just as important in vaccine efficiency. Through the progress in nanotechnology, various nanoparticles have been evaluated as carriers for these substances. Among them, alginate nanoparticles are a good choice because of their biodegradability, biocompatibility, ease of production, etc. In this study, feasibility of alginate nanoparticles (NPs) such as recombinant LTB from Enterotoxigenic Escherichia coli (ETEC) carrier was investigated. To do this, the eltb gene was cloned and expressed in E...
February 20, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29459694/human-antibody-responses-against-non-covalently-cell-wall-bound-staphylococcus-aureus-proteins
#17
Francisco Romero Pastrana, Jolanda Neef, Dennis G A M Koedijk, Douwe de Graaf, José Duipmans, Marcel F Jonkman, Susanne Engelmann, Jan Maarten van Dijl, Girbe Buist
Human antibody responses to pathogens, like Staphylococcus aureus, are important indicators for in vivo expression and immunogenicity of particular bacterial components. Accordingly, comparing the antibody responses to S. aureus components may serve to predict their potential applicability as antigens for vaccination. The present study was aimed at assessing immunoglobulin G (IgG) responses elicited by non-covalently cell surface-bound proteins of S. aureus, which thus far received relatively little attention...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459064/comparison-of-serum-bactericidal-and-antibody-titers-induced-by-two-haemophilus-influenzae-type-b-conjugate-vaccines-a-phase-iii-randomized-double-blind-study
#18
Yukihiro Akeda, Yuka Koizumi, Yohei Takanami, Shuji Sumino, Yumi Hattori, Kayoko Sugizaki, Nodoka Mitsuya, Kazunori Oishi
Haemophilus influenzae type b (Hib) conjugate vaccines have drastically reduced disease incidence worldwide. Protection against Hib infection has relied on the serum bactericidal activity (SBA) of antibodies to the Hib capsular polysaccharide (polyribosylribitol phosphate). However, licensure usually relies on measuring induction of antibodies to PRP as a surrogate for SBA. In a phase III clinical trial we compared a PRP-conjugate vaccine using the nontoxic diphtheria toxin mutant, CRM197 , as carrier protein with the licensed tetanus toxoid conjugate when administered subcutaneously as a three dose primary series in Japanese infants...
February 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29458539/immunogenicity-in-chickens-with-orally-administered-recombinant-chicken-borne-lactobacillus-saerimneri-expressing-fima-and-ompc-antigen-of-o78-avian-pathogenic-escherichia-coli
#19
Sun-Ting Ma, Guo-Jie Ding, Xue-Wei Huang, Zi-Wei Wang, Li Wang, Mei-Ling Yu, Wen Shi, Yan-Ping Jiang, Li-Jie Tang, Yi-Gang Xu, Yi-Jing Li
PURPOSE: Avian colibacillosis is responsible for economic losses to poultry producers worldwide. To combat this, we aimed to develop an effective oral vaccine for chicken against O78 avian pathogenic Escherichia coli (APEC) infection through a Lactobacillus delivery system. METHODOLOGY: Eight Lactobacillus strains isolated from the intestines of broiler chickens were evaluated based on their in vitro adherence ability to assess their potential as a delivery vector...
January 19, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29458538/the-double-adjuvants-ltb-and-cpg-significantly-enhanced-the-immuno-protective-effects-of-recombinant-git-derived-from-staphylococcus-aureus-and-streptococcus-in-mice
#20
Jinzhu Ma, Liquan Yu, Baifen Song, Yongzhong Yu, Shaoduo Zhang, Yuhua Wei, Zhijun Wu, Di Yao, Wei Yu, Zhanbo Zhu, Yudong Cui
PURPOSE: In this study, we prepared GapC1-150-IsdB126-361-TRAP (GIT) proteins plus heat-labile enterotoxin B (LTB) as an intra-molecular adjuvant, together with CpG to further enhance its immunogenicity. METHODOLOGY: Initially, the target genes were acquired and inserted into pET-32a (+) vectors to express LTB-GIT protein. LTB-GIT expression was confirmed by Western blotting and its immunocompetence was estimated through ELISA. Further, we immunized BALB/c mice with the LTB-GIT plus CpG adjuvant...
January 17, 2018: Journal of Medical Microbiology
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