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https://www.readbyqxmd.com/read/29045910/immunogenicity-and-protective-efficacy-of-multistage-vaccine-candidates-mtb8-4-hspx-and-hspx-mtb8-4-against-mycobacterium-tuberculosis-infection-in-mice
#1
Wanbo Liu, Jingjing Li, Hongxia Niu, Xiaofa Lin, Ruiying Li, Yue Wang, Qi Xin, Hongjuan Yu, Yumin Wu, Bingdong Zhu, Jiying Tan
In this study, Mtb8.4 and HspX, which are expressed at proliferating and dormant stages of Mycobacterium tuberculosis (M. tuberculosis), respectively, were chosen to construct two fusion proteins, Mtb8.4-HspX (8.4H) and HspX-Mtb8.4 (H8.4), and we investigated whether the antigen dose and protein sequential order could impact the immunogenicity and protective efficacy of these fusion protein vaccines against M. tuberculosis. C57BL/6 mice were vaccinated with new constructions containing a fusion protein with adjuvant of N, N'-dimethyl-N, N'-dioctadecylammonium bromide (DDA) or a mixed adjuvant composed of DDA, polyribocytidylic acid and gelatin (DPG), and the antigen specific immune responses and protective efficacy against M...
October 15, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29045781/development-of-clickable-monophosphoryl-lipid-as-towards-semi-synthetic-conjugates-with-tumor-associated-carbohydrate-antigens
#2
Marcello Ziaco, Sabina Górska, Serena Traboni, Agnieszka Maria Razim, Angela Casillo, Alfonso Iadonisi, Andrzej Gamian, Maria Michela Corsaro, Emiliano Bedini
A semi-synthetic strategy for the obtainment of monophosphoryl lipid A derivatives equipped with clickable (azide, alkyne, double bond, a thiol precursor) moieties, starting from the native lipid A isolated from Escherichia coli, is here presented. These lipid A derivatives can be conjugated with other interesting biomolecules, such as tumor-associated carbohydrate antigens (TACAs). In this way, the immunostimulant activity of monophosphoryl lipid A can significantly improve the immunogenicity of TACAs, thus opening an access to potential self-adjuvant anticancer vaccine candidates...
October 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29042202/efficacy-of-the-oral-rabies-virus-vaccine-strain-spbn-gasgas-in-foxes-and-raccoon-dogs
#3
Conrad M Freuling, Elisa Eggerbauer, Stefan Finke, Christiane Kaiser, Christian Kaiser, Antje Kretzschmar, Tobias Nolden, Steffen Ortmann, Charlotte Schröder, Jens P Teifke, Peter Schuster, Ad Vos, Thomas C Mettenleiter, Thomas Müller
To test the immunogenicity and efficacy of a new oral rabies virus vaccine strain SPBN GASGAS in wildlife target species, one group of foxes and two groups of raccoon dogs were offered a bait containing 1.7 ml of the vaccine (10(6.6) FFU/ml; 10(6.8) FFU/dose) and subsequently challenged approximately 180 days later with a fox rabies virus isolate. One group of raccoon dogs (n=30) received the same challenge dose (10(0.7) MICLD50/ml) as the red foxes (n=29). The other group with raccoon dogs (n=28) together with 8 animals that received the vaccine dose by direct instillation into the oral cavity (DIOC) were infected with a 40-fold higher dose of the challenge virus (10(2...
October 14, 2017: Vaccine
https://www.readbyqxmd.com/read/29042201/newcastle-disease-virus-ndv-recombinant-expressing-the-hemagglutinin-of-h7n9-avian-influenza-virus-protects-chickens-against-ndv-and-highly-pathogenic-avian-influenza-a-h7n9-virus-challenges
#4
Zenglei Hu, Xiaowen Liu, Xinan Jiao, Xiufan Liu
The emerged highly pathogenic avian influenza A (H7N9) (HPAI) viruses in China pose a dual challenge to public health and poultry industry. Thus H7N9 vaccines are in an urgent need. In this study, we constructed a Newcastle disease virus (NDV)-vectored vaccine (rLXHAF) expressing the hemagglutinin (HA) of H7N9 virus fused with the transmembrane/cytoplasmic tail domain of the NDV fusion protein. rLXHAF stably expressed the HA protein, exhibited similar growth kinetics and pathogenicity as the parental virus...
October 14, 2017: Vaccine
https://www.readbyqxmd.com/read/29039103/analysis-of-nanoparticle-adjuvant-properties-in-vivo
#5
Barry W Neun, Marina A Dobrovolskaia
Nanoparticles can be engineered for targeted antigen delivery to the immune cells and for stimulating the immune response to improve the antigen immunogenicity. This approach is commonly used to develop nanotechnology-based vaccines. In addition, some nanotechnology platforms may be initially designed for drug delivery, but in the course of subsequent characterization, their additional immunomodulatory functions may be discovered that can potentially benefit vaccine efficacy. In both of these scenarios, an in vivo proof of concept study to verify the utility of the nanocarrier for improving vaccine efficacy is needed...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29038320/persistence-of-immunity-after-vaccination-with-a-capsular-group-b-meningococcal-vaccine-in-3-different-toddler-schedules
#6
Manish Sadarangani, Tim Sell, Mildred A Iro, Matthew D Snape, Merryn Voysey, Adam Finn, Paul T Heath, Gianni Bona, Susanna Esposito, Javier Diez-Domingo, Roman Prymula, Adefowope Odueyungbo, Daniela Toneatto, Andrew J Pollard
BACKGROUND: One schedule for the capsular group B meningococcal vaccine 4CMenB is 2 doses that are administered 2 months apart for children aged 12-23 months, with a booster dose 12-24 months later. Our objective was to provide data on persistence of human serum bactericidal antibody (hSBA) titres in children up to 4 years of age after initial doses at 12-24 months, and immunogenicity of a booster dose at 48 months of age compared with vaccine-naive children. METHODS: Children previously immunized, as part of a randomized controlled trial, with 2 doses of 4CMenB vaccine at 12-24 months of age received a booster at 4 years of age...
October 16, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29037578/a-phase-i-safety-and-immunogenicity-dose-escalation-trial-of-plague-vaccine-flagellin-f1-v-in-healthy-adult-volunteers-dmid-08-0066
#7
Sharon E Frey, Kathleen Lottenbach, Irene Graham, Edwin Anderson, Kanwaldeep Bajwa, Ryan C May, Steven B Mizel, Aaron Graff, Robert B Belshe
INTRODUCTION: Intentional aerosolization of Yersinia pestis may result in pneumonic plague which is highly fatal if not treated early. METHODS: We conducted a phase 1 randomized, double blind (within each group), placebo controlled, dose escalation trial to evaluate a plague vaccine, Flagellin/F1/V, in healthy adults aged 8 through 45years. Vaccine was administered intramuscularly on Days 0 and 28 at a dose of 1, 3, 6 or 10mcg. Subjects were observed for 4h after vaccination for cytokine release syndrome...
October 13, 2017: Vaccine
https://www.readbyqxmd.com/read/29035947/cross-reactivity-of-hiv-vaccine-responses-and-the-microbiome
#8
Wilton B Williams, Qifeng Han, Barton F Haynes
PURPOSE OF REVIEW: A successful HIV-type 1 (HIV-1) vaccine will require immunogens that induce protective immune responses. However, recent studies suggest that the response to HIV-1 and perhaps other viruses may be altered by immune system exposure to intestinal microbiota-antigens. This review will discuss select aspects of these studies. RECENT FINDINGS: Naïve CD4 T and B cell repertoires can be imprinted by intestinal microbiota-antigens to respond to virus epitopes prior to virus infection...
October 14, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29035321/a-novel-multi-epitope-vaccine-based-on-urate-transporter-1-alleviates-streptozotocin-induced-diabetes-by-producing-anti-urat1-antibody-and-an-immunomodulatory-effect-in-c57bl-6j-mice
#9
Yanjie Ma, Huimin Cao, Zhixin Li, Jinzhi Fang, Xiaomin Wei, Peng Cheng, Rui Jiao, Xiaoran Liu, Ya Li, Yun Xing, Jiali Tang, Liang Jin, Taiming Li
Hyperuricemia (HUA) is related to diabetes. Uric acid-induced inflammation and oxidative stress are risk factors for diabetes and its complications. Human urate transporter 1 (URAT1) regulates the renal tubular reabsorption of uric acid. IA-2(5)-P2-1, a potent immunogenic carrier designed by our laboratory, can induce high-titer specific antibodies when it carries a B cell epitope, such as B cell epitopes of DPP4 (Dipeptidyl peptidase-4), xanthine oxidase. In this report, we describe a novel multi-epitope vaccine composing a peptide of URAT1, an anti-diabetic B epitope of insulinoma antigen-2(IA-2) and a Th2 epitope (P2:IPALDSLTPANED) of P277 peptide in human heat shock protein 60 (HSP60)...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29031816/designing-immunostimulatory-double-stranded-messenger-rna-with-maintained-translational-activity-through-hybridization-with-poly-a-sequences-for-effective-vaccination
#10
Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka
Messenger (m)RNA vaccines require a safe and potent immunostimulatory adjuvant. In this study, we introduced immunostimulatory properties directly into mRNA molecules by hybridizing them with complementary RNA to create highly immunogenic double stranded (ds)RNAs. These dsRNA formulations, comprised entirely of RNA, are expected to be safe and highly efficient due to antigen expression and immunostimulation occurring simultaneously in the same antigen presenting cells. In this strategy, design of dsRNA is important...
September 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/29031693/a-brief-review-on-the-immunological-scenario-and-recent-developmental-status-of-vaccines-against-enteric-fever
#11
REVIEW
Debaki Ranjan Howlader, Hemanta Koley, Suhrid Maiti, Ushasi Bhaumik, Priyadarshini Mukherjee, Shanta Dutta
Enteric fever has been one of the leading causes of severe illness and deaths worldwide. S. Typhi and S. Paratyphi A, B and C are important enteric fever-causing organisms globally. This infection causes about 21 million cases among which 222,000 typhoid related deaths occurred in 2015. These estimates do not reflect the ultimate and real status of the disease due to the lack of unified diagnostic and proper reporting system from typhoid endemic and other regions. Current control strategies have become increasingly ineffective due to the emergence of multi-drug resistance among the strains...
October 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29031042/humoral-and-cellular-immune-response-of-mice-challenged-with-yersinia-pestis-antigenic-preparations
#12
Elida A Leal, Josimar D Moreira, Fernanda F Nunes, Larissa R Souza, Janaina M Martins, Vicente P C Toledo, Alzira M P Almeida, Tania M P Guimarães
OBJECTIVES: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. pestis, we assessed the role of these antigens in inducing an immune response...
October 11, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029942/immunogenicity-of-aluminum-adsorbed-hepatitis-a-vaccine-havrix%C3%A2-administered-as-a-third-dose-after-primary-doses-of-japanese-aluminum-free-hepatitis-a-vaccine-aimmugen%C3%A2-for-japanese-travelers-to-endemic-countries
#13
Shinji Fukushima, Tomoko Kiyohara, Koji Ishii, Takashi Nakano, Atsuo Hamada
BACKGROUND: Hepatitis A vaccination is recommended for travelers to endemic countries. Several inactivated aluminum-adsorbed hepatitis A vaccines are available worldwide, but only one licensed hepatitis A vaccine is available in Japan. This vaccine is a lyophilized inactivated aluminum-free hepatitis A vaccine (Aimmugen®). The standard schedule of Aimmugen® is three doses (at 0, 2-4 weeks, and 6 months). Japanese people will go abroad after receiving 2 doses of Aimmugen®. Some long-term travelers will receive the third dose of hepatitis A vaccine at their destination, at 6-24 months after 2 doses of Aimmugen®...
October 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29029400/rat-embryonic-fibroblasts-immortalized-by-mrps18-2-protein-are-target-for-nk-cells
#14
Muhammad Mushtaq, Pradeepa N Pangigadde, Suhas Darekar, Erik Dissen, Elena Kashuba
Overexpression of the human mitochondrial ribosomal protein MRPS18-2 (S18-2) led to immortalization of primary rat embryonic fibroblasts (REFs). The derived cells (18IM) expressed embryonic stem cell markers. Noteworthy, genes encoding the COX family proteins were up-regulated significantly. It is known that the COX family proteins are involved in the regulation of immune response. In the present work we demonstrate that 18IM cells behave like stem cells when subjected to directed differentiation in vitro. However, unlike stem cells, 18IM cells do not develop tumors in vivo, in SCID mice...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029260/an-adjuvanted-postfusion-f-protein-based-vaccine-did-not-prevent-respiratory-syncytial-virus-illness-in-older-adults
#15
Judith Falloon, Jing Yu, Mark T Esser, Tonya Villafana, Li Yu, Filip Dubovsky, Therese Takas, Myron J Levin, Ann R Falsey
Background: Respiratory syncytial virus (RSV) is an important cause of illness in older adults. This study assessed efficacy of a vaccine for prevention of RSV-associated acute respiratory illness (RSV-ARI), defined by specified symptoms with virologic confirmation. Methods: This phase 2b study evaluated RSV postfusion F protein (120 µg) with glucopyranosyl lipid adjuvant (5 µg) in 2% stable emulsion. Subjects aged ≥60 years were randomized 1:1 to vaccine or placebo (all received influenza vaccine)...
September 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029224/immunogenicity-and-safety-of-an-adjuvanted-herpes-zoster-subunit-vaccine-co-administered-with-seasonal-influenza-vaccine-in-adults-aged-50-years-and-older
#16
Tino F Schwarz, Naresh Aggarwal, Beate Moeckesch, Isabelle Schenkenberger, Carine Claeys, Martine Douha, Olivier Godeaux, Katrijn Grupping, Thomas C Heineman, Marta Lopez Fauqued, Lidia Oostvogels, Peter Van den Steen, Himal Lal
Background: The immunogenicity and safety of an adjuvanted herpes zoster subunit vaccine (HZ/su) when co-administered with a quadrivalent seasonal inactivated influenza vaccine (IIV4) was investigated in a phase 3, open-label, randomized clinical trial in adults aged ≥50 years. Methods: Subjects were randomized 1:1 to receive either HZ/su (VZV glycoprotein E [gE]; AS01B Adjuvant System) and IIV4 at day 0 followed by a second HZ/su dose at month 2 (Co-ad group), or IIV4 at month 0 and HZ/su at months 2 and 4 (Control group)...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029122/immunogenicity-and-safety-of-the-hz-su-adjuvanted-herpes-zoster-subunit-vaccine-in-adults-previously-vaccinated-with-a-live-attenuated-herpes-zoster-vaccine
#17
Katrijn Grupping, Laura Campora, Martine Douha, Thomas C Heineman, Nicola P Klein, Himal Lal, James Peterson, Ilse Vastiau, Lidia Oostvogels
Background: Protection against herpes zoster (HZ) induced by the live-attenuated zoster vaccine Zostavax (ZVL) wanes within 3-7 years. Re-vaccination may renew protection. We assessed whether (re)-vaccination with the adjuvanted HZ subunit vaccine candidate (HZ/su) induced comparable immune responses in previous ZVL-recipients and ZVL-naïve individuals (HZ-NonVac). Methods: In an open-label, multicenter study (NCT02581410), adults ≥65 years of age, vaccinated with ZVL ≥5 years previously (HZ-PreVac), were matched to HZ-NonVac adults...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028973/safety-and-immunogenicity-of-newborn-mva85a-vaccination-and-selective-delayed-bacille-calmette-guerin-bcg-for-infants-of-hiv-infected-mothers-a-phase-2-randomized-controlled-trial
#18
Elisa Nemes, Anneke C Hesseling, Michele Tameris, Katya Mauff, Katrina Downing, Humphrey Mulenga, Penelope Rose, Marieke van der Zalm, Sharon Mbaba, Danelle Van As, Willem A Hanekom, Gerhard Walzl, Thomas J Scriba, Helen McShane, Mark Hatherill
Background: Vaccination of HIV-infected infants with bacille Calmette-Guérin (BCG) is contraindicated. HIV-exposed newborns need a new tuberculosis (TB) vaccination strategy that protects against TB early in life; and avoids the potential risk of BCG disease until after HIV infection has been excluded. Methods: This double-blind randomized controlled trial compared newborn MVA85A prime vaccination (1 x10 8 PFU) vs. Candin® control, followed by selective deferred BCG vaccination at 8 weeks of age for HIV-uninfected infants, and 12 months follow-up for safety and immunogenicity...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29027811/prevention-of-human-papillomavirus-hpv-related-tumors-in-people-living-with-human-immunodeficiency-virus-hiv
#19
Mario Poljak, Anja Šterbenc, Maja M Lunar
In comparison to their HIV-negative counterparts, people living with HIV (PLWH) have a higher prevalence of human papillomavirus (HPV) infection in various anatomical sites coupled with increased HPV persistence, higher risk of HPV-related tumors, and faster disease progression. Areas covered: Gender-neutral prevention strategies for HPV-related cancers in PLWH discussed: ABC approach, HPV vaccination, antiretroviral treatment (ART), anal cancer screening, and smoking cessation. Gender specific strategies: cervical cancer screening reduces the incidence and mortality of cervical cancer and circumcision might reduce the risk of HPV infections in men...
October 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29027637/vaccine-adjuvants-smart-components-to-boost-the-immune-system
#20
REVIEW
Rakesh Bastola, Gyubin Noh, Taekwang Keum, Santosh Bashyal, Jo-Eun Seo, Jaewoong Choi, Yeonsu Oh, YoungSik Cho, Sangkil Lee
Vaccination is an effective approach to prevent the consequences of infectious diseases. Vaccines strengthen immunity and make individuals resistant to infections with pathogens. Although conventional vaccines are highly immunogenic, they are associated with some safety issues. Subunit vaccines are safe, but they require adjuvants to stimulate the immune system because of their weaker immunogenicity. Adjuvants are entities incorporated into vaccines to increase the immunogenic responses of antigens. They play a crucial role in increasing the potency and efficacy of vaccines...
October 13, 2017: Archives of Pharmacal Research
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