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https://www.readbyqxmd.com/read/29126301/coagulation-testing-in-the-core-laboratory
#1
William E Winter, Sherri D Flax, Neil S Harris
Primary hemostasis begins with endothelial injury. VWF, produced by endothelial cells, binds to platelets and links them to subendothelial collagen. Platelet-derived ADP and thromboxane activate non-adhered platelets via their GPIIb/IIIa receptors, allowing these platelets to participate in platelet aggregation. Secondary hemostasis is initiated with the binding of factor VII to extravascular tissue factor (TF). Factors II, VII, IX and X are vitamin K-dependent factors. The role of vitamin K is to assist in the addition of gamma carboxylate groups to glutamic acids in the "GLA" domains of these factors...
November 8, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29115871/attendance-at-fragile-x-specialty-clinics-facilitators-and-barriers
#2
Sharon A Kidd, Melissa Raspa, Renée Clark, Holly Usrey-Roos, Anne C Wheeler, Jessica A Liu, Amanda Wylie, Stephanie L Sherman
The objectives were to describe the demographic characteristics of children with Fragile X syndrome (FXS) and to determine predictors of attendance at Fragile X (FX) clinics. Findings from the Community Support Network (CSN) and Our Fragile X World (OFXW) samples showed that children who attended FX Clinics were mostly male, high-school aged or younger, and white, non-Hispanic. Using logistic regression models, awareness about FX Clinic services, guardian education, and income (CSN), and child age, family income, and total number of co-occurring conditions (OFXW) were predictors of clinic attendance...
November 2017: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29099365/removal-of-calcium-hydroxide-intracanal-medicament-by-different-irrigants-and-irrigating-techniques-a-cone-beam-computed-tomography-analysis
#3
Prasanna Neelakantan, Priyanka Sriraman, James L Gutmann
The aim of this study was to use cone beam computed tomography (CBCT) to evaluate the removal of calcium hydroxide (Ca[OH]2) from root canals after using different irrigation and activation protocols. Root canals (n = 128) were filled with Ca(OH)2 and scanned using CBCT. The Ca(OH)2 was removed after 1 week using 1 of 12 groups (G1-G12) according to the final irrigating solution: G1, 6% sodium hypochlorite (NaOCl) + 18% etidronic acid (EA) with no activation; G2, NaOCL + EA + passive ultrasonic irrigation (PUI); G3, NaOCl + EA + Finishing File (FF); G4, NaOCl + EA + NaviTip FX irrigation needle (NTFX); G5, 3% NaOCl + 17% ethylenediaminetetraacetic acid (EDTA) with no activation; G6, NaOCl + EDTA + PUI; G7, NaOCl + EDTA + FF; G8, NaOCl + EDTA + NTFX; G9, 3% NaOCl with no activation; G10, NaOCl + PUI; G11, NaOCl + FF; G12, NaOCL + NTFX...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29098144/exploration-of-superior-modality-safety-and-efficacy-of-hypofractioned-image-guided-intensity-modulated-radiation-therapy-in-patients-with-unresectable-but-confined-intrahepatic-hepatocellular-carcinoma
#4
Tao Jiang, Zhao-Chong Zeng, Ping Yang, Yong Hu
Purpose: To evaluate the efficacy and safety of hypofractioned image-guided intensity modulated radiation therapy (IG-IMRT) for unresectable but confined intrahepatic hepatocellular carcinoma in comparison with conventional 3-dimensional conformal radiotherapy (3D-CRT). Methods: Ninety patients with unresectable but confined intrahepatic hepatocellular carcinoma without distant metastasis and tumor thrombosis received external beam radiation therapy. Of these patients, 45 received IG-IMRT and 45 received 3D-CRT...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29081657/comparative-analysis-of-the-long-term-effect-of-two-families-of-high-flux-polysulfone-dialysers-on-platelet-count-a-retrospective-cross-sectional-study
#5
Rosaria Del Giorno, Lorenzo Berwert, Silvio Pianca, Giorgia Bianchi, Olivier Giannini, Luca Gabutti
INTRODUCTION: Thrombocytopenia is a potential complication of hemodialysis (HD), and its occurrence has been described even with highly biocompatible polysulfone (PSf) membranes. Dialysis units routinely monitor platelet (PLT) count at the beginning of HD sessions. However, considering that the long-term effects on PLT count could easily be missed, the prevalence of HD-related thrombocytopenia could be underestimated. In the present study, we aimed to investigate the following: 1) the long-term impact of HD treatment on PLT count, comparing two families of dialysis membranes made up of similar PSfs; 2) whether the switch between the dialysis membranes studied significantly affects PLT count; and 3) the prevalence and the risk of HD-induced thrombocytopenia according to the dialysis membranes used...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29072911/the-design-of-small-molecule-active-site-inhibitors-of-the-s1a-family-proteases-as-procoagulant-and-anticoagulant-drugs
#6
Peter M Fischer
Vitamin K antagonists (VKA) have long been the default drugs for anticoagulant management in venous thrombosis. While efficacious, they are difficult to use due to interpatient dose-response variability and the risks of bleeding. The approval of fondaparinux, a heparin-derived factor Xa (fXa) inhibitor, provided validation for the development of direct oral anticoagulants (DOAC), and currently such inhibitors of thrombin and fXa are in clinical use. These agents can be used without regular coagulation monitoring but the inherent risk of bleeding complications associated with blocking the common coagulation pathway remains...
October 26, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29068378/primary-and-immortalized-human-respiratory-cells-display-different-patterns-of-cytotoxicity-and-cytokine-release-upon-exposure-to-deoxynivalenol-nivalenol-and-fusarenon-x
#7
Silvia Ferreira Lopes, Gaëlle Vacher, Eleonora Ciarlo, Dessislava Savova-Bianchi, Thierry Roger, Hélène Niculita-Hirzel
The type B trichothecene mycotoxins deoxynivalenol (DON), nivalenol (NIV) and fusarenon-X (FX) are structurally related secondary metabolites frequently produced by Fusarium on wheat. Consequently, DON, NIV and FX contaminate wheat dusts, exposing grain workers to toxins by inhalation. Those trichothecenes at low, relevant, exposition concentrations have differential effects on intestinal cells, but whether such differences exist with respiratory cells is mostly unknown, while it is required to assess the combined risk of exposure to mycotoxins...
October 25, 2017: Toxins
https://www.readbyqxmd.com/read/29066393/mutations-in-algal-and-cyanobacterial-photosystem-i-that-independently-affect-the-yield-of-initial-charge-separation-in-the-two-electron-transfer-cofactor-branches
#8
Syed Lal Badshah, Junlei Sun, Sam Mula, Mike Gorka, Patricia Baker, Rajiv Luthra, Su Lin, Art van der Est, John H Golbeck, Kevin E Redding
In Photosystem I, light-induced electron transfer can occur in either of two symmetry-related branches of cofactors, each of which is composed of a pair of chlorophylls (ec2A/ec3A or ec2B/ec3B) and a phylloquinone (PhQA or PhQB). The axial ligand to the central Mg(2+) of the ec2A and ec2B chlorophylls is a water molecule that is also H-bonded to a nearby Asn residue. Here, we investigate the importance of this interaction for charge separation by converting each of the Asn residues to a Leu in the green alga, Chlamydomonas reinhardtii, and the cyanobacterium, Synechocystis sp...
October 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29049743/additional-veno-venous-gas-exchange-as-a-problem-solving-strategy-for-an-oxygenator-not-transferring-oxygen-in-paediatric-cardiopulmonary-bypass
#9
Wolfgang Boettcher, Nicodème Sinzobahamvya, Frank Dehmel, Andreas Matschke, Andre Iben, Mi-Young Cho, Mathias Redlin, Joachim Photiadis
OBJECTIVES: Oxygenator failure during cardiopulmonary bypass constitutes a life-threatening event, especially when perfusion is conducted under normothermia. An alternative solution to emergency oxygenator changeover is described. METHODS: A supplementary oxygenator is added in the venous line without interrupting perfusion. De-airing is achieved through the cardiotomy reservoir. Oxygen supply is adapted to ensure physiologic partial oxygen pressure. RESULTS: On 5 occasions in the past 4 years, Capiox Baby FX 05 oxygenator (n = 4) and Capiox FX15 (n = 1) failed to exchange blood gases after bypass run ranging from 290 min to 563 min...
November 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29048706/assessment-of-monomer-release-from-3-different-fissure-sealants
#10
K Görkem Ulu Güzel, Işıl Sönmez
BACKGROUND: Light-activated resin-based dental fissure sealants are the most widely accepted among clinicians. The objective of this study was to determine monomer release of 3 different light-curing fissure sealants in vitro: Control Seal (Voco, Germany), Fissurit FX (Voco, Germany) and R&D Series Fıssured Nova (Imicrly, Turkey). METHODS: Each material was polymerized with a curing light: Valo Cordless (Ultradent) LED in standard mode for 20 seconds (n = 27) and 40 seconds (n = 27) and in Xtra power mode (plasma arc) for 3 seconds (n = 27)...
October 18, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/29047929/finite-element-simulation-of-light-transfer-in-turbid-media-under-structured-illumination
#11
Dong Hu, Renfu Lu, Yibin Ying
The spatial-frequency domain (SFD) imaging technique allows us to estimate the optical properties of biological tissues in a wide field of view. The technique is, however, prone to error in measurement because the two crucial assumptions used for deriving the analytical solution to the diffusion approximation cannot be met perfectly in practical applications. This research mainly focused on modeling light transfer in turbid media under the normal incidence of structured illumination using the finite element method (FEM)...
July 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29045560/inflammatory-gastrointestinal-diseases-associated-with-pd-1-blockade-antibodies
#12
M Collins, J M Michot, F X Danlos, C Mussini, E Soularue, C Mateus, D Loirat, A Buisson, I Rosa, O Lambotte, S Laghouati, N Chaput, C Coutzac, A L Voisin, J C Soria, A Marabelle, S Champiat, C Robert, F Carbonnel
Background: Immune check-point blockade agents have shown clinical activity in cancer patients but are associated with immune-related adverse events that could limit their development. The aim of this study was to describe the gastrointestinal immune-related adverse events (GI-irAE) in patients with cancer treated with anti-PD-1. Methods: this is a retrospective study of consecutive adult patients who had a suspected GI-irAE due to anti-PD-1 antibodies between 2013 and 2016...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29042366/emicizumab-a-bispecific-antibody-recognizing-coagulation-factors-ix-and-x-how-does-it-actually-compare-to-factor-viii
#13
Peter J Lenting, Cécile V Denis, Olivier D Christophe
During the last decade, the development of improved and novel approaches for the treatment of hemophilia A has expanded tremendously. These approaches include factor VIII (FVIII) with extended half-life (e.g. FVIII-Fc and PEGylated FVIII), monoclonal antibodies targeting tissue factor pathway inhibitor, si-RNA to reduce antithrombin expression and the bispecific antibody ACE910/Emicizumab. Emicizumab is a bispecific antibody recognizing both the enzyme factor IXa (FIXa) and the substrate factor X (FX). By simultaneously binding enzyme and substrate, Emicizumab mimics some part of the function exerted by the original cofactor FVIII, in that it promotes co-localization of the enzyme/substrate complex...
October 17, 2017: Blood
https://www.readbyqxmd.com/read/29033318/an-alkynyl-fucose-halts-hepatoma-cell-migration-and-invasion-by-inhibiting-gdp-fucose-synthesizing-enzyme-fx-tsta3
#14
Yasuhiko Kizuka, Miyako Nakano, Yoshiki Yamaguchi, Kazuki Nakajima, Ritsuko Oka, Keiko Sato, Chien-Tai Ren, Tsui-Ling Hsu, Chi-Huey Wong, Naoyuki Taniguchi
Fucosylation is a glycan modification critically involved in cancer and inflammation. Although potent fucosylation inhibitors are useful for basic and clinical research, only a few inhibitors have been developed. Here, we focus on a fucose analog with an alkyne group, 6-alkynyl-fucose (6-Alk-Fuc), which is used widely as a detection probe for fucosylated glycans, but is also suggested for use as a fucosylation inhibitor. Our glycan analysis using lectin and mass spectrometry demonstrated that 6-Alk-Fuc is a potent and general inhibitor of cellular fucosylation, with much higher potency than the existing inhibitor, 2-fluoro-fucose (2-F-Fuc)...
September 19, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29030666/lc-pda-apciitms-identification-of-algal-carotenoid-and-oxysterol-precursors-to-fatty-acid-esters-in-hydrolyzed-extracts-of-the-freshwater-mussel-dreissena-bugensis
#15
Maxime C Bridoux, Monika Sobiechowska, Alicia Pérez-Fuentetaja, Katherine T Alben
Carotenyl fatty acid esters (carotenyl-FAEs) were extracted in acetone from freeze-dried Dreissena bugensis (Lakes Erie and Ontario) and hydrolyzed to identify the carotenoid precursors. Analysis by liquid chromatography (LC) with photodiode array (PDA) and atmospheric pressure chemical ionization-ion trap mass spectrometry (APCIitMS) revealed the major hydrolysis products: fucoxanthinol (FOH) from fucoxanthin (FX, diatoms); mactraxanthin (MX) from violaxanthin (VX, chlorophytes); 4-fold higher levels of an unknown, tentatively identified as an adduct of two closely eluting C27H46O3 and C27H48O3 steryl triols...
October 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29024249/bone-strength-in-girls-and-boys-following-a-distal-radius-fracture-a-2-year-hr-pqct-double-cohort-study
#16
Heather M Macdonald, Mikko Määttä, Leigh Gabel, Kishore Mulpuri, Heather A McKay
PURPOSE: We recently reported impaired bone strength in girls with low- to moderate-energy distal radius fractures (Fx) compared with girls with no history of forearm fractures (Non-Fx). We aimed to determine whether bone strength deficits observed at baseline were still present after two years. METHODS: We assessed bone strength, microarchitecture and BMD of the non-fractured (Fx) and non-dominant (Non-Fx) distal radius (7% site) at baseline, 12- and 24-months using high-resolution pQCT (Scanco Medical) in 104 girls (11...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28992973/rivaroxaban-ameliorates-disease-course-in-an-animal-model-of-multiple-sclerosis
#17
Monika Merker, Susann Eichler, Alexander M Herrmann, Heinz Wiendl, Christoph Kleinschnitz, Kerstin Göbel, Sven G Meuth
Recent studies have implicated an important role for coagulation factors in neuroinflammatory disorders like multiple sclerosis (MS). Here, we investigate the role of factor X (FX) in neuroinflammation by using rivaroxaban the selective inhibitor of activated FX (FXa) in experimental autoimmune encephalomyelitis (EAE, an animal model of MS). Rivaroxaban-treated rats were less susceptible to EAE compared to the untreated control group. This finding was accompanied by reduced T-cell infiltration and microglia activation...
September 21, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28991618/optimization-of-transversal-phacoemulsification-settings-in-peristaltic-mode-using-a-new-transversal-ultrasound-machine
#18
Dannen D Wright, Alex J Wright, Tyler D Boulter, Ashlie A Bernhisel, Brian C Stagg, Brian Zaugg, Jeff H Pettey, Larry Ha, Brian T Ta, Randall J Olson
PURPOSE: To determine the optimum bottle height, vacuum, aspiration rate, and power settings in the peristaltic mode of the Whitestar Signature Pro machine with Ellips FX tip action (transversal). SETTING: John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Porcine lens nuclei were hardened with formalin and cut into 2.0 mm cubes. Lens cubes were emulsified using transversal and fragment removal time (efficiency), and fragment bounces off the tip (chatter) were measured to determine optimum aspiration rate, bottle height, vacuum, and power settings in the peristaltic mode...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28990814/induction-of-anoikis-in-human-colorectal-cancer-cells-by-fucoxanthinol
#19
Masaru Terasaki, Hayato Maeda, Kazuo Miyashita, Michihiro Mutoh
Fucoxanthin (Fx), one of the major xanthophylls in brown algae, is known to be effective for colorectal cancer (CRC) chemoprevention through inhibiting cell growth, cell cycle and caspase activation. Recently, we observed fucoxanthinol (FuOH), an anti-cancer active metabolite of Fx, treatment of human CRC cells resulted in plenty of living floating cells several hours after exposure, and induced apoptosis. In the present study, we investigated whether FuOH induced anchorage-dependent apoptosis, that is "anoikis", along with integrin signal suppression in human CRC cells...
October 9, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28987251/the-importance-of-mean-neutrophil-volume-mnv-values-in-differential-diagnosis-of-bacterial-sepsis
#20
Birol Şafak, Özgür Baykan, Osman Kılınç, Diğdem Özer Yıldırım
INTRODUCTION: Bloodstream infections are a significant cause of morbidity and mortality in hospitalized patients. Blood cultures and other laboratory tests are used for diagnosis. Among these tests, the mean neutrophil volume (MNV) value is reported as a potential indicator that supports the diagnosis of sepsis. Our study identified the MNV values of patients via microorganisms cultivated from blood cultures and examined the role of these MNV values in the early diagnosis of bloodstream infections...
2017: Journal of the National Medical Association
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