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https://www.readbyqxmd.com/read/29776134/detection-of-intensity-bursts-using-hawkes-processes-an-application-to-high-frequency-financial-data
#1
Marcello Rambaldi, Vladimir Filimonov, Fabrizio Lillo
Given a stationary point process, an intensity burst is defined as a short time period during which the number of counts is larger than the typical count rate. It might signal a local nonstationarity or the presence of an external perturbation to the system. In this paper we propose a procedure for the detection of intensity bursts within the Hawkes process framework. By using a model selection scheme we show that our procedure can be used to detect intensity bursts when both their occurrence time and their total number is unknown...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29771474/neurocog-fx-study-a-multicenter-cohort-study-on-cognitive-dysfunction-in-patients-with-early-breast-cancer
#2
Oliver Rick, Monika Reuß-Borst, Timm Dauelsberg, Holger Hass, Volker König, Reiner Caspari, Gabriele Götz-Keil, Jürgen Pfitzner, Christa Kerschgens, Klaus Fliessbach, Christian Hoppe
OBJECTIVE: Complaints about cognitive dysfunction (CD) reportedly persist in approximately one third of breast cancer patients but the nature of CD and possible risk factors are unknown. METHODS: A cross-sectional, multicenter study was set-up at 9 German oncological rehabilitation centers. Objective cognitive performance was assessed by the NeuroCog FX test, a short computerized screening (duration <30 min) which assesses working memory, alertness, verbal/figural memory and language/executive...
May 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29749569/postoperative-hypofractionated-stereotactic-brain-radiation-hsrt-for-resected-brain-metastases-improved-local-control-with-higher-bed-10
#3
Aryavarta M S Kumar, Jonathan Miller, Seth A Hoffer, David B Mansur, Michael Coffey, Simon S Lo, Andrew E Sloan, Mitchell Machtay
INTRODUCTION: HSRT directed to large surgical beds in patients with resected brain metastases improves local control while sparing patients the toxicity associated with whole brain radiation. We review our institutional series to determine factors predictive of local failure. METHODS: In a total of 39 consecutive patients with brain metastases treated from August 2011 to August 2016, 43 surgical beds were treated with HSRT in three or five fractions. All treatments were completed on a robotic radiosurgery platform using the 6D Skull tracking system...
May 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29742341/luminescence-tunable-polynorbornenes-for-simultaneous-multicolor-imaging-in-subcellular-organelles
#4
Nan Xie, Ke Feng, Jianqun Shao, Bin Chen, Chen-Ho Tung, Li-Zhu Wu
Through modular ROMP (ring-opening metathesis polymerization), biofunctional polynorbornenes are designed and fabricated from panchromatic fluorophores, bioactive peptides and PEG solubilizer for organelle-specific multicolor imaging. Attributed to the free permutation and combination of highly fluorescent red rhodamine B, green dichlorofluorescein and blue 9,10-diphenylanthracene fluorophores as well as signaling peptide sequences of Fx rFx K and TAT, we successfully realize simultaneous multicolor imaging toward lysosomes and mitochondria in living cells firstly utilizing polymeric scaffolds...
May 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29734520/routine-measurements-of-factor-viii-activity-and-inhibitor-titer-in-the-presence-of-emicizumab-utilizing-anti-idiotype-monoclonal-antibodies
#5
Keiji Nogami, Tetsuhiro Soeda, Tomoko Matsumoto, Yoshiki Kawabe, Takehisa Kitazawa, Midori Shima
BACKGROUND: Emicizumab is an anti-factor (F)IXa/X bispecific monoclonal antibody (mAb), mimicking the Factor (F)VIIIa cofactor activity. Emicizumab does not require activation by thrombin and its shortening effect on the activated partial prothrombin time (aPTT) is more pronounced than that of Factor (F)VIII. aPTT-based FVIII activity (FVIII:C) and FVIII inhibiter titer measurements are influenced by the presence of emicizumab. AIM: To establish a reliable aPTT-based assay to measure FVIII in the presence of emicizumab...
May 7, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29712651/resistance-to-echinocandins-in-candida-can-be-detected-by-performing-the-etest-directly-on-blood-culture-samples
#6
María Ángeles Bordallo-Cardona, Laura Judith Marcos-Zambrano, Carlos Sánchez-Carrillo, Emilio Bouza, Patricia Muñoz, Pilar Escribano, Jesús Guinea
Background: We examined the rapid evaluation of susceptibility to echinocandins in Candida spp. using the Etest performed directly on positive blood cultures and anidulafungin-containing agar plates. Methods: We prospectively collected 80 positive blood cultures (Bactec™-FX system, Becton-Dickinson, Cockeysville, Maryland, USA) with echinocandin-susceptible Candida spp (n=60) and echinocandin-intermediate C. parapsilosis (n=20) from patients with candidemia. Additionally, blood culture bottles of nonfungemic/bacteremic patients were spiked with 35 echinocandin-resistant Candida spp...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29707881/prophylactic-treatment-of-bleeding-episodes-in-children-12-years-with-moderate-to-severe-hereditary-factor-x-deficiency-fxd-efficacy-and-safety-of-a-high-purity-plasma-derived-factor-x-pdfx-concentrate
#7
R Liesner, C Akanezi, M Norton, J Payne
BACKGROUND: Hereditary factor X (FX) deficiency (FXD) affects 1:500 000-1:1 000 000 people worldwide. A novel, high-purity plasma-derived FX concentrate (pdFX) is available in the United States and European Union as replacement therapy for FXD, but data are scarce on pdFX use in children <12 years. AIM: This prospective, open-label phase 3 study assessed the safety, efficacy and pharmacokinetics of pdFX in children <12 years with moderate/severe FXD. METHODS: Subjects aged <12 years with basal plasma FX activity (FX:C) <5 IU/dL received pdFX as prophylactic and on-demand treatment, with doses adjusted to maintain FX:C > 5 IU/dL...
April 30, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29691099/influence-of-aortic-neck-characteristics-on-successful-aortic-wall-penetration-of-endoanchors-in-therapeutic-use-during-endovascular-aneurysm-repair
#8
Seline R Goudeketting, Kim van Noort, Kenneth Ouriel, William D Jordan, Jean M Panneton, Cornelis H Slump, Jean-Paul P M de Vries
OBJECTIVE: This study sought to quantify EndoAnchor (Medtronic Vascular, Santa Rosa, Calif) penetration into the aortic wall in patients undergoing endovascular abdominal aortic aneurysm repair and to assess predictors of successful penetration and its relationship to postprocedural type IA endoleak. METHODS: A subset of patients from the Aneurysm Treatment Using the Heli-FX Aortic Securement System Global Registry (ANCHOR) were included if they met the following criteria: the indication for EndoAnchor use was to treat a type IA endoleak, and postprocedure contrast-enhanced computed tomography (CT) scans of sufficient quality were available for core laboratory review...
April 21, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29674828/depth-and-percentage-of-resin-based-sealer-penetration-inside-the-dentinal-tubules-using-endovac-endoactivator-navi-tip-fx-irrigation-system-a-confocal-laser-scanning-microscope-study
#9
Ramesh Bharti, Aseem Prakash Tikku, Anil Chandra, Vijay Kumar Shakya, Simith Yadav
Aim: This in vitro study was conducted to evaluate the effect of EndoVac, EndoActivator, and Navy Tip FX irrigation system on lateral depth and percentage of sealer penetration into the dentinal tubules using confocal laser scanning microscope. Materials and Methods: Forty recently extracted single-rooted mandibular premolars were taken and root canal treatment was performed using three different irrigation system, that is, EndoVac, EndoActivator, and Navi tip FX...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29661614/a-fluorescence-based-imaging-approach-to-pharmacokinetic-analysis-of-intracochlear-drug-delivery
#10
Andrew M Ayoob, Marcello Peppi, Vishal Tandon, Robert Langer, Jeffrey T Borenstein
Advances in microelectromechanical systems (MEMS) technologies are enhancing the development of intracochlear delivery devices for the treatment of hearing loss with emerging pharmacological therapies. Direct intracochlear delivery addresses the limitations of systemic and intratympanic delivery. However, optimization of delivery parameters for these devices requires pharmacokinetic assessment of the spatiotemporal drug distribution inside the cochlea. Robust methods of measuring drug concentration in the perilymph have been developed, but lack spatial resolution along the tonotopic axis or require complex physiological measurements...
April 5, 2018: Hearing Research
https://www.readbyqxmd.com/read/29655757/fucoxanthin-bioavailability-from-fucoxanthin-fortified-milk-in-vivo-and-in-vitro-study
#11
Il-Kyoon Mok, Jae Kwon Lee, Jeong Hwa Kim, Cheol-Ho Pan, Sang Min Kim
Our previous study reported the improved stability of fucoxanthin (FX) fortified in whole milk (WM) and skimmed milk (SM). In this study, in vivo and in vitro FX bioavailability were investigated using FX-fortified milk (FX-SM and FX-WM) and microalga Phaeodactylum tricornutum biomass (Pt-powder). Organ tissue accumulation of FX and its metabolites (FXOH: fucoxanthinol, AXA: amarouciaxanthin A) after repeated oral administration was in the following order: FX-SM > FX-WM > Pt-powder. In vivo pharmacokinetic study with a single oral administration also demonstrated that the absorption of FXOH and AXA was the highest for FX-SM...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29645406/modified-clot-waveform-analysis-to-measure-plasma-coagulation-potential-in-the-presence-of-the-anti-factor-ixa-factor-x-bispecific-antibody-emicizumab
#12
Keiji Nogami, Tomoko Matsumoto, Yuka Tabuchi, Tetsuhiro Soeda, Nobuo Arai, Takehisa Kitazawa, Midori Shima
BACKGROUND: Emicizumab is an anti-factor (F)IXa/FX bispecific antibody that mimics FVIIIa cofactor function. Emicizumab does not require activation by thrombin and its effect on shortening activated partial prothrombin time (aPTT) is much greater relative to FVIII. The aPTT has limited utility, therefore, in hemophilia A patients (HA-pts) treated with emicizumab. AIM: To evaluate the global coagulation potential of emicizumab. METHODS: Clot waveform analysis (CWA) with prothrombin time (PT)/aPTT-mixed reagents was used to define hemostatic monitoring protocols in HA-pts...
April 12, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29643610/effect-of-the-trunk-forward-bending-angle-in-sitting-position-on-slow-vital-capacity
#13
Juncheol Lee, Dongwook Han
[Purpose] The purpose of this study was to examine whether a trunk forward bending angle in sitting position affected slow vital capacity (SVC). [Subjects and Methods] The subjects of this study were 18 healthy college students to whom the study's methods and purpose were explained and their agreement for participation was obtained. Slow vital capacity was measured using spirometry (Pony FX, COSMED Inc., Italy), repeatedly at a body bending angle of 0°, 15°, and 30° in the sitting position. [Results] Vital capacity, expiratory reserve volume, and inspiratory reserve volume were significantly different according to the trunk forward bending angle...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29626988/thrombin-generation-test-a-reliable-tool-to-evaluate-the-pharmacodynamics-of-vitamin-k-antagonist-rodenticides-in-rats
#14
Jourdi Georges, Lefèbvre Sebastien, Le Bonniec Bernard, Curis Emmanuel, Gaussem Pascale, Lattard Virginie, Siguret Virginie
Vitamin K antagonist rodenticide pharmacodynamics (PD) is studied in rodents with traditional laboratory tests. We wondered if thrombin generation test (TGT) could add value. Difethialone (10 mg/kg) was administered per os to 97 OFA-Sprague Dawley rats. PD was studied over a 72 h-period using the Calibrated Automated Thrombogram on platelet poor plasma before and after intoxication (3 female and 3 male rats for each 13 time points) and TGT parameters were compared with the prothrombin time (PT) and vitamin K dependent factor activities previously reported...
April 2018: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29624513/mice-with-diet-induced-obesity-demonstrate-a-relative-prothrombotic-factor-profile-and-a-thicker-aorta-with-reduced-ex-vivo-function
#15
Aykut G Uner, Cengiz Unsal, Humeyra Unsal, Mumin A Erdogan, Ece Koc, Mehmet Ekici, Hamdi Avci, Muharrem Balkaya, Ferda Belge, Lokman Tarin
: Classical risk factors such as cholesterol and lipoproteins are currently not sufficient to explain all physiopathological processes of obesity-related vascular dysfunction as well as atherosclerosis and arteriosclerosis. Therefore, the discovery of potential markers involved in vascular dysfunction in the obese state is still needed. Disturbances in hemostatic factors may be involved in the developmental processes associated with obesity-related cardiovascular disorders. We hypothesized that alterations of several hemostatic factors in the obese state could correlate with the function and morphology of the aorta and it could play an important role in the development of vascular dysfunction...
April 4, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29622683/peak-forelimb-ground-reaction-forces-experienced-by-dogs-jumping-from-a-simulated-car-boot
#16
David Pardey, Gillian Tabor, James Andrew Oxley, Alison P Wills
Many dog owners allow their pets to jump out of a car boot; however, to date, there has been no study that has investigated whether this places dogs at risk of injury. The aim of this study was to investigate the relationship between height and peak vertical ground reaction force (vGRF) in static start jumps. Fifteen healthy adult dogs performed three jumps from a platform that represented common vehicle boot sill heights (0.55, 0.65, 0.75 m), landing on a single force platform. Kinetic data (mediolateral (Fx), craniocaudal (Fy) and vertical (Fz)) were normalised for body weight and analysed via a one-way repeated analysis of variance (ANOVA) and pairwise post hoc tests with a Bonferroni correction applied...
April 5, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29614522/contribution-of-factor-viii-a2-domain-residues-400-409-to-a-factor-x-interactive-site-in-the-factor-xase-complex
#17
Masahiro Takeyama, Keiji Nogami, Kana Sasai, Shoko Furukawa, Midori Shima
The link between factor (F)VIII and FX is essential for optimum activity of the tenase complex. The interactive site(s) in FVIII for FX remains to be completely clarified, however. We investigated the FVIII A2 domain-FX association that was speculated from inhibitory mechanism(s) by an anti-A2 autoantibody. SDS-PAGE demonstrated that the purified inhibitor IgG recognizing residues 373-562 blocked FXa cleavage at Arg372 in FVIII, and surface-plasmon resonance (SPR)-based assays showed that intact A2 subunit directly bound to FX ( K d ; 63 nM)...
April 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29609581/mild-not-severe-disc-degeneration-is-implicated-in-the-progression-of-bilateral-l5-spondylolysis-to-spondylolisthesis
#18
Vivek A S Ramakrishna, Uphar Chamoli, Luke L Viglione, Naomi Tsafnat, Ashish D Diwan
BACKGROUND: Spondylolytic (or lytic) spondylolisthesis is often associated with disc degeneration at the index-level; however, it is not clear if disc degeneration is the cause or the consequence of lytic spondylolisthesis. The main objective of this computed tomography based finite element modelling study was to examine the role of different grades of disc degeneration in the progression of a bilateral L5-lytic defect to spondylolisthesis. METHODS: High-resolution computed tomography data of the lumbosacral spine from an anonymised healthy male subject (26 years old) were segmented to build a 3D-computational model of an INTACT L1-S1 spine...
April 2, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29603113/fucoxanthin-elicits-epigenetic-modifications-nrf2-activation-and-blocking-transformation-in-mouse-skin-jb6-p-cells
#19
Yuqing Yang, Irene Yang, Mingnan Cao, Zheng-Yuan Su, Renyi Wu, Yue Guo, Mingzhu Fang, Ah-Ng Kong
Nuclear factor erythroid-2-related factor-2 (Nrf2 or NFE2L2) is a master regulator of the anti-oxidative stress response, which is involved in the defense against many oxidative stress/inflammation-mediated diseases, including anticancer effects elicited by an increasing number of natural products. Our previous studies showed that the epigenetic modification of the Nrf2 gene plays a key role in restoring the expression of Nrf2. In this study, we aimed to investigate the epigenetic regulation of Nrf2 by astaxanthin (AST) and fucoxanthin (FX), carotenoids which are abundant in microalgae and seaweeds, in mouse skin epidermal JB6 P+ cells...
February 20, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29601832/antidepressant-effects-of-acupoint-stimulation-and-fluoxetine-by-increasing-dendritic-arborization-and-spine-density-in-ca1-hippocampal-neurons-of-socially-isolated-rats
#20
Amalia Dávila-Hernández, Sergio R Zamudio, Lucía Martínez-Mota, Roberto González-González, Eduardo Ramírez-San Juan
Given the importance of depression and the adverse effects of conventional treatment, it is necessary to seek complementary therapies. In a rat model of depression, this study aimed to assess the behavioral and morphological effects of embedding absorbable thread in acupoints (acu-catgut), and compare the results to those of fluoxetine treatment and the corresponding control groups. Therefore, depressive-like behavior was evaluated with the forced swimming test, and dendritic morphology (in the CA1 hippocampal region) with the Golgi-Cox technique and Sholl analysis...
March 27, 2018: Neuroscience Letters
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