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Cindy Hughes
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January 2017: Family Practice Management
Marko Dimiskovski, Richard Scheinfield, Dwight Higgin, Alexander Krupka, Michel A Lemay
BACKGROUND: The measurement of ground reaction forces (GRFs) in animals trained to locomote on a treadmill after spinal cord injury (SCI) could prove valuable for evaluating training outcomes; however, quantitative measures of the GRFs in spinal felines are limited. NEW METHOD: A split belt treadmill was designed and constructed to measure the GRFs of feline hindlimbs during stepping. The treadmill consists of two independent treadmill assemblies, each mounted on a force plate...
January 6, 2017: Journal of Neuroscience Methods
Satoshi Abe, Yoshiki Kubota, Kei Shibuya, Yoshinari Koyama, Takanori Abe, Tatsuya Ohno, Takashi Nakano
PURPOSE: The aim of this study was to compare the dose-volume parameters of fiducial marker matching (MM) with vertebral body matching (VM) in patient positioning for carbon ion radiotherapy for primary hepatic cancer. MATERIALS AND METHODS: Twenty patients with primary hepatic cancer were retrospectively studied to assess changes in reproducibility of tumor position and dose distribution on two CT scans. One was for treatment planning and another was for dose confirmation, acquired the day before the first treatment day...
January 2, 2017: Physica Medica: PM
Moshe Sagi, Lior Nesher, Pablo Yagupsky
The performance of the BACTEC FX blood culture system for detecting Brucella bacteremia within the routine one-week incubation period was assessed in a prospective study conducted in an endemic area for B. melitensis in southern Israel. Aerobic vials (BD BACTEC™ Plus Aerobic/F Medium) inoculated with blood specimens obtained from adult patients with a positive Rose-Bengal screening test were monitored for four consecutive weeks and blind subcultures of negative vials were performed on solid media on days 7 and 28...
January 4, 2017: Journal of Clinical Microbiology
A Lau, H Liu, L Ren, S Ahmad, Y Chen
PURPOSE: To quantify the simulated mean absorbed dose per technique (cGy/mAs) from a commercially available microCT scanner using various filtration techniques. METHODS: Monte Carlo simulations using the Geant4 toolkit (version 10) was used utilizing the standard electromagnetic physics model. The Quantum FX microCT scanner (PerkinElmer, Waltham, MA) was modeled incorporating measured energy spectra and spatial dimensions of nominal source-to-object (SOD) distances...
June 2016: Medical Physics
L Vazquez Quino, C Huerta Hernandez, A Morrow, B Massingill, D Rangaraj
PURPOSE: To evaluate the use of MobiusFX as a pre-treatment verification IMRT QA tool and compare it with a commercial 4D detector array for VMAT plan QA. METHODS: 15 VMAT plan QA of different treatment sites were delivered and measured by traditional means with the 4D detector array ArcCheck (Sun Nuclear corporation) and at the same time measurement in linac treatment logs (Varian Dynalogs files) were analyzed from the same delivery with MobiusFX software (Mobius Medical Systems)...
June 2016: Medical Physics
M Fast, C Kamerling, S Crijns, M Menten, S Nill, B Raaymakers, U Oelfke
PURPOSE: In tracked dynamic multi-leaf collimator (MLC) treatments, segments are continuously adapted to the target centroid motion in beams-eye-view. On-the-fly segment adaptation, however, potentially induces dosimetric errors due to the finite MLC leaf width and non-rigid target motion. In this study, we outline a novel tool for computing the 4d dose of lung SBRT plans delivered with MLC tracking. METHODS: The following automated workflow was developed: A) centroid tracking, where the initial segments are morphed to each 4dCT phase based on the beams-eye-view GTV shift (followed by a dose calculation on each phase); B) re-optimized tracking, in which all morphed initial plans from (A) are further optimised ("warm-started") in each 4dCT phase using the initial optimisation parameters but phase-specific volume definitions...
June 2016: Medical Physics
V Wu, M Epelman, K Brock, M Feng, R Ten Haken, M Matuszak
PURPOSE: Interfraction changes in abdominal SBRT patient anatomy are challenging to address with image guidance alone because avoidance of an overlapping high-priority gastrointestinal normal structure may come at the expense of tumor coverage. This work investigates the benefit of anticipating interfraction motion and exploiting favorable geometries at the time of treatment through dose adaptive planning. METHODS: Beyond no change, six scenarios of duodenum shifts per fraction are generated (±1 cm XYZ) and sample five-fraction paths (combinations of no and/or the indicated changes) are simulated...
June 2016: Medical Physics
C Teng, C Ainsley, B Teo, B Burgdorf, G Janssens, A Berman, W Levin, Y Xiao, L Lin, C Simone, T Solberg
PURPOSE: In the light of tumor regression and normal tissue changes, dose distributions can deviate undesirably from what was planned. As a consequence, replanning is sometimes necessary during treatment to ensure continued tumor coverage or to avoid overdosing organs at risk (OARs). Proton plans are generally thought to be less robust than photon plans because of the proton beam's higher sensitivity to changes in tissue composition, suggesting also a higher likely replanning rate due to tumor regression...
June 2016: Medical Physics
C Nelson, M Garcia, E Calderon, S Kirsner
PURPOSE: Log file based IMRT and VMAT QA is a system that analyzes treatment log files and uses delivery parameters to compute the dose to the patient/phantom. This system was previously commissioned for Varian machines, the purpose of this work is to describe the process for commissioning Mobius for use with Elekta machines. METHODS: Twelve IMRT and VMAT plans (6×) were planned and delivered and dose was measured using MapCheck, the results were compared to that computed by Mobius...
June 2016: Medical Physics
S Zhou, Q Wu, Q Fan, Y Lei, S Li, X Li, R Ma, S Wang, X Wang, D Zheng, X Zhu, C Enke
PURPOSE: Equivalent Square (ES) is a widely used concept in radiotherapy. It enables us to determine many important quantities for a rectangular treatment field, without measurement, based on the corresponding values from its ES field. In this study, we propose a Generalized Mean (GM) type ES formula and compare it with other established formulae using benchmark datasets. METHODS: Our GM approach is expressed as ES=(w•fx^α+(1-w)•fy^α)^(1/α), where fx, fy, α, and w represent field sizes, power index, and a weighting factor, respectively...
June 2016: Medical Physics
H Zhang
PURPOSE: To evaluate the dosimetric metrics of HDR Ring and Tandem applicator Brachytherapy for primary cervical cancers. METHODS: The dosimetric metrics of high-risk clinical target volumes (HDR-CTV) of 12 patients (in total 60 fractions/plans) treated with the HDR ring and tandem applicators were retrospectively analyzed. Ring diameter is from 2.6 to 3.4 cm, tandem length is from 4 to 6 cm, and the angle is either 45 or 60 degrees. The first fraction plan was MR guided, the MR images were then used as a reference for contouring the HR-CTV in CT images of following 4 fractions...
June 2016: Medical Physics
M Moteabbed, A Trofimov, G Sharp, Y Wang, A Zietman, J Efstathiou, H Lu
PURPOSE: To investigate the impact of anatomy/setup variations on standard vs. hypofractionated anterolateral pencil beam scanning (PBS) proton therapy for prostate cancer. METHODS: Six prostate cancer patients treated with double-scattering proton therapy, who underwent weekly verification CT scans were selected. Implanted fiducials were used for localization, and endorectal balloons for immobilization. New PBS plans using combination of lateral and anterior-oblique (AO) (±35 deg) beams were created...
June 2016: Medical Physics
K Hack, F Renzi, E Hess, F Lauber, J Douxfils, J M Dogné, G R Cornelis
BACKGROUND: Capnocytophaga canimorsus is a Gram-negative bacterium, which belongs to the oral flora of dogs and causes fulminant sepsis in humans who have been bitten, licked or scratched. In patients, bleeding abnormalities, such as petechiae, purpura fulminans or disseminated intravascular coagulation (DIC) occur frequently. OBJECTIVE: We investigated whether C. canimorsus could actively contribute to these bleeding abnormalities. METHODS: Calibrated automated thrombogram and clotting time assays were performed to assess the anticoagulant activity of C...
December 28, 2016: Journal of Thrombosis and Haemostasis: JTH
H Mohd Nazri, A A Suhair, W A R Wan Suriana, Z Zefarina, H Azlan, A Wan Zaidah
Factor X (FX) deficiency is a rare autosomal recessive congenital bleeding disorder. The clinical presentation is among the most severe among the rare coagulation defects. Thus, majority of diagnosed patients will receive factor replacement therapy before surgical manipulation. However, the diagnosis of FX deficiency may be overlooked because it is a rare entity. This is a case report of a 15-year-old male patient who was diagnosed with FX deficiency after developing post-operative complications. With regular fresh frozen plasma infusion given, the patient responded well and recovered...
December 2016: Malaysian Journal of Pathology
Ting-Ting Guo, Li-Li Li, Xing-Yuan Men, Zeng-Bin Lu, Hao Chen, Zhen-Ying Wang, Ting-Lin Sun, Yi Yu
Athetis dissimilis (Hampson) has emerged as a serious pest on corn in recent years in China. Understanding the population response of A. dissimilis to temperature will be beneficial for adopting control strategies for this pest. The impact of five constant temperatures (17, 21, 25, 29, and 33 °C) on the life table of A. dissimilis was studied using age-stage, two-sex life table method in the laboratory. The results showed that the developmental time of egg, larva, pupa, and adult decreased when temperature increased from 17 °C to 33 °C...
December 23, 2016: Journal of Economic Entomology
J Grandoni, G Perret, C Forier
INTRODUCTION/AIM: LR769 is a new second-generation recombinant human Factor VIIa (rhFVIIa) developed for haemophilia treatment. We determined enzymatic properties of LR769 and its interaction with antithrombin, tissue factor, platelets and endothelial protein C receptor (EPCR), compared with NovoSevenRT. METHODS: Kinetic enzyme assays and active site titration were used for enzymatic studies. Surface Plasmon Resonance (SPR) was used for determination of binding constants...
December 19, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
Daniel Contaifer, Daniel E Carl, Urszula Osinska Warncke, Erika J Martin, Bassem M Mohammed, Benjamin Van Tassell, Donald F Brophy, Charles Chalfant, Dayanjan S Wijesinghe
Hemodialysis and peritoneal dialysis are the primary means of managing end stage renal disease (ESRD). However, these treatment modalities are associated with the onset of coagulation abnormalities. Effective management of coagulation risk among these patients requires the identification of surrogate markers that provide an early indication of the coagulation abnormalities. The role of sphingolipids in the manifestation and prediction of coagulation abnormalities among dialysis patients have never been investigated...
December 19, 2016: Journal of Lipid Research
E Sornay-Rendu, F Duboeuf, S Boutroy, R D Chapurlat
The relationships between body composition and bone mineral density are well established but the contribution of body composition to the risk of fracture (Fx) has rarely been evaluated prospectively. We analyzed the risk of Fx by body composition in 595 postmenopausal women (mean age 66±8years) from a longitudinal cohort study (Os des Femmes de Lyon). We assessed the risk of the first incident fragility Fx according to body composition obtained from whole-body DXA: abdominal visceral (VFAT) and subcutaneous fat mass (SFAT), total body fat mass (FM), lean mass index (LMI) and appendicular skeletal muscle mass index (ASMI)...
October 27, 2016: Bone
Qian Yu, Minchao Li
Research has shown that mechanical stress stimulation can cause airway remodeling. We investigate the effects of mechanical stretch on the expression of the airway remodeling-associated factors interleukin-13 (IL-13) and matrix metalloprotein-9 (MMP-9) and signaling pathways in human bronchial epithelioid (16HBE) cells under mechanical stretch. A Flexcell FX-4000 Tension System with a flexible substrate was applied to stretch 16HBE cells at a 15% elongation amplitude and 1Hz frequency, with stretching for 0...
January 25, 2017: Journal of Biomechanics
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