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https://www.readbyqxmd.com/read/29620271/mir%C3%A2-152-regulates-tgf%C3%A2-%C3%AE-1%C3%A2-induced-epithelial%C3%A2-mesenchymal-transition-by-targeting-hpip-in-tubular-epithelial-cells
#1
Ya-Xian Ning, Xiao-Yuan Wang, Jian-Qin Wang, Rong Zeng, Gou-Qin Wang
Renal fibrosis is a common pathological feature of chronic kidney diseases, and their development and progression are influenced by epigenetic modifications including aberrant microRNA (miRNA or miR) expression. miRNAs have been demonstrated to modulate the aggressiveness of various cancers and have emerged as possible therapeutic agents for the management of renal fibrosis. Transforming growth factor β1 (TGF‑β1)‑induced epithelial‑mesenchymal transition (EMT) of tubular epithelial cells serves a role in the initiation and progression of renal fibrosis...
April 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29589299/dissecting-oncogenic-rtk-pathways-in-colorectal-cancer-initiation-and-progression
#2
Stephen McManus, Walid Chababi, Dominique Arsenault, Claire M Dubois, Caroline Saucier
Colorectal cancer (CRC) is a progressive disorder associated with an accumulation of multiple heterogeneous genetic alterations in intestinal epithelial cells (IEC). However, when these cells undergo neoplastic transformation and become cancerous and metastatic, they invariably acquire hallmarks conferring them the ability to hyperproliferate, escape growth-inhibitory and death-inducing cues, and promote angiogenesis as well as epithelial-to-mesenchymal transformation (EMT), fostering their invasive dissemination from primary tumor into distant tissues...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29577543/a-forkhead-box-protein-c2-inhibitor-targeting-epithelial-mesenchymal-transition-and-cancer-metastasis
#3
Maria Castaneda, Luxi Chen, Lagnajeet Pradhan, Shichang Li, Ruba Zein, Yeongju Lee, Hyun-Suk Lim, Hyun-Joo Nam, Jiyong Lee
The epithelial-mesenchymal transition (EMT) has been suggested as a new target for therapeutic intervention of metastatic cancer. A forkhead Box Protein C2 (FOXC2) is known to be necessary to initiate and maintain EMT, and therefore bestow on cancer cells metastatic and cancer stem cell (CSC)-like phenotypes, allowing cells to acquire higher motility, invasiveness, self-renewal and therapy-resistance. Here, we describe the first inhibitor of FOXC2, MC-1-F2. MC-1-F2 was able to induce cadherin switching and reverse EMT through the degradation of FOXC2 and blocking its nuclear localization...
March 25, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29559846/frizzled7-promotes-epithelial-to-mesenchymal-transition-and-stemness-via-activating-canonical-wnt-%C3%AE-catenin-pathway-in-gastric-cancer
#4
Guanman Li, Qiao Su, Haibo Liu, Dong Wang, Wenhui Zhang, Zhenhai Lu, Yu Chen, Xiaohui Huang, Wen Li, Changhua Zhang, Yulong He, Li Fu, Jiong Bi
Aberrant activation of Wnt signaling is a crucial event in tumor development and metastasis. Wnt signaling is commonly divided into canonical and non-canonical signaling pathways based on whether β-catenin is activated (canonical). The two signaling pathways are initiated by Wnt ligand binding to the surface Frizzled (FZD) receptors, and regulate cancer stem cell self-renewal and epithelial-mesenchymal transition (EMT). Frizzled 7 (FZD7), a member of Frizzled family, promotes cell proliferation and invasiveness in many cancers, suggesting that FZD7 transmitting Wnt signaling is important for driving cancer growth...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29551682/enrichment-of-glioma-stem-cell-like-cells-on-3d-porous-scaffolds-composed-of-different-extracellular-matrix
#5
Xuanzhi Wang, Xingliang Dai, Xinzhi Zhang, Xinda Li, Tao Xu, Qing Lan
Cancer stem cells (CSCs), being tumor-initiating with self-renewal capacity and heterogeneity, are most likely the cause of tumor resistance, reoccurrence and metastasis. To further investigate the role of CSCs in tumor biology, there is a need to develop an effective culture system to grow, maintain and enrich CSCs. Three-dimensional (3D) cell culture model has been widely used in tumor research and drug screening. Recently, researchers have begun to utilize 3D models to culture cancer cells for CSCs enrichment...
March 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29544731/autocrine-transforming-growth-factor-%C3%AE-activin-a-smad-signaling-induces-hepatic-progenitor-cells-undergoing-partial-epithelial-mesenchymal-transition-states
#6
Yu Wu, Ze-Yang Ding, Guan-Nan Jin, Yi-Xiao Xiong, Bin Yu, Yi-Min Sun, Wei Wang, Hui-Fang Liang, Bixiang Zhang, Xiao-Ping Chen
Hepatic progenitor cells (HPCs) are a subpopulation of cells which was usually expanded in chronic liver injury and are contributed to liver regeneration through differentiating into hepatocytes and cholangiocytes. Epithelial-mesenchymal transition is a dynamic process which is important for the progression of liver fibrosis and cancer initiation. This study demonstrated that LE/6 and WB-F344 cells, both of which were HPC derived cell lines, were undergoing partial epithelial-mesenchymal transition states, which was indicated by the co-expression of epithelial markers (E-cadherin and zona occludin 1), and mesenchymal markers (vimentin, fibronectin, collagen 1and α-SMA)...
March 12, 2018: Biochimie
https://www.readbyqxmd.com/read/29518912/role-of-akt-isoforms-controlling-cancer-stem-cell-survival-phenotype-and-self-renewal
#7
REVIEW
Sergio Rivas, Carla Gómez-Oro, Inés M Antón, Francisco Wandosell
The cancer stem cell (CSC) hypothesis suggests that tumours are maintained by a subpopulation of cells with stem cell properties. Although the existence of CSCs was initially described in human leukaemia, less evidence exists for CSCs in solid tumours. Recently, a CD133+ cell subpopulation was isolated from human brain tumoursexhibiting stem cell properties in vitro as well as the capacity to initiate tumours in vivo. In the present work, we try to summarize the data showing that some elements of the Phosphoinositide 3-kinase Class I (PI3K)/ Thymoma viral oncogene protein kinase (Akt) pathway, such the activity of PI3K Class I or Akt2, are necessary to maintain the CSC-like phenotype as well as survival of CSCs (also denoted as tumour-initiating cells (TICs))...
March 7, 2018: Biomedicines
https://www.readbyqxmd.com/read/29518612/nicotine-upregulates-fgfr3-and-rb1-expression-and-promotes-non-small-cell-lung-cancer-cell-proliferation-and-epithelial-to-mesenchymal-transition-via-downregulation-of-mir-99b-and-mir-192
#8
Xuemei Du, Fei Qi, Sheyu Lu, Yongchun Li, Wei Han
BACKGROUND: Tobacco smoke is by far the greatest risk factor for non-small-cell lung cancer (NSCLC). Nicotine, an active alkaloid in tobacco, is unable to initiate tumorigenesis in humans and rodents, but can promote the growth and metastasis of various tumors, including NSCLC, initiated by tobacco carcinogens. Recently, cigarette smoke is reported to downregulate 24 miRNAs more than 3-fold in the lungs of rats, and most of these downregulated miRNAs are associated with NSCLC initiation and development...
March 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29503447/lin28b-enhanced-tumorigenesis-in-an-autochthonous-kras-g12v-driven-lung-carcinoma-mouse-model
#9
Lydia Meder, Katharina König, Felix Dietlein, Iris Macheleidt, Alexandra Florin, Meryem S Ercanoglu, Ursula Rommerscheidt-Fuss, Mirjam Koker, Gisela Schön, Margarete Odenthal, Florian Klein, Reinhard Büttner, Johannes H Schulte, Lukas C Heukamp, Roland T Ullrich
LIN28B is a RNA-binding protein regulating predominantly let-7 microRNAs with essential functions in inflammation, wound healing, embryonic stem cells, and cancer. LIN28B expression is associated with tumor initiation, progression, resistance, and poor outcome in several solid cancers, including lung cancer. However, the functional role of LIN28B, especially in non-small cell lung adenocarcinomas, remains elusive. Here, we investigated the effects of LIN28B expression on lung tumorigenesis using LIN28B transgenic overexpression in an autochthonous KRASG12V -driven mouse model...
March 5, 2018: Oncogene
https://www.readbyqxmd.com/read/29468299/smad4-and-epithelial-mesenchymal-transition-proteins-in-colorectal-carcinoma-an-immunohistochemical-study
#10
M Ioannou, E Kouvaras, R Papamichali, M Samara, I Chiotoglou, G Koukoulis
Epithelial-mesenchymal transition (EMT) plays an important role in cancer metastasis. During EMT, tumor cells acquire the capacity to migrate and invade the stroma. Activation of the transforming growth factor-b (TGF-b) signaling pathway is of major importance for the initiation of EMT. Smad4, an essential protein of this pathway, is known to complex with multiple transcription factors (e.g. Snail-1, Slug, Twist-1), in various types of cancer, promoting the repression or activation of target genes. The role of Smad4 in colorectal cancer (CRC) is not straightforward so far...
February 21, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29467255/altered-translation-initiation-of-gja1-limits-gap-junction-formation-during-epithelial-mesenchymal-transition
#11
Carissa C James, Michael J Zeitz, Patrick J Calhoun, Samy Lamouille, James W Smyth
Epithelial-mesenchymal transition (EMT) is activated during development, wound healing, and pathologies including fibrosis and cancer metastasis. Hallmarks of EMT are remodeling of intercellular junctions and adhesion proteins, including gap junctions. The GJA1 mRNA transcript encoding the gap junction protein connexin43 (Cx43) has been demonstrated to undergo internal translation initiation, yielding truncated isoforms that modulate gap junctions. The PI3K/Akt/mTOR pathway is central to translation regulation and is activated during EMT, leading us to hypothesize that altered translation initiation would contribute to gap junction loss...
February 21, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29464017/regulation-of-e-cadherin-localization-by-microtubule-targeting-agents-rapid-promotion-of-cortical-e-cadherin-through-p130cas-src-inhibition-by-eribulin
#12
Nicholas F Dybdal-Hargreaves, April L Risinger, Susan L Mooberry
Microtubule targeting agents (MTAs) are some of the most effective anticancer drugs used to treat a wide variety of adult and pediatric cancers. Building evidence suggests that these drugs inhibit interphase signaling events and that this contributes to their anticancer actions. The effects of diverse MTAs were evaluated following a 2 hour incubation with clinically relevant concentrations to test the hypothesis that these drugs rapidly and differentially disrupt epithelial-to-mesenchymal transition (EMT)-related signaling...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29456682/l1cam-promotes-epithelial-to-mesenchymal-transition-and-formation-of-cancer-initiating-cells-in-human-endometrial-cancer
#13
Jinlong Chen, Fufeng Gao, Naifu Liu
Identification of novel factors critical for epithelial to mesenchymal transition (EMT) and cancer initiating cell (CIC) formation may aid in the identification of novel therapeutics for the treatment of endometrial cancer. The present study demonstrated that L1 cell adhesion molecule (CAM) is critical for EMT and formation of CICs in endometrial cancer. Overexpression of L1CAM may promote EMT with increased formation of CICs in HEC-1A endometrial cancer cells. CICs and mesenchymal status resist chemotherapeutic drugs and may regenerate the various cell types in tumors, thereby resulting in relapse of the disease...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434219/nemopilema-nomurai-jellyfish-venom-exerts-an-anti-metastatic-effect-by-inhibiting-smad-and-nf-%C3%AE%C2%BAb-mediated-epithelial-mesenchymal-transition-in-hepg2-cells
#14
Hyunkyoung Lee, Min Jung Pyo, Seong Kyeong Bae, Yunwi Heo, Indu Choudhary, Duhyeon Hwang, Hyeryeon Yang, Je-Hein Kim, Jinho Chae, Chang Hoon Han, Changkeun Kang, Seungshic Yum, Euikyung Kim
Epithelial-mesenchymal transition (EMT) is a key initial step in metastasis for malignant cancer cells to obtain invasive and motile properties. Inhibiting EMT has become a new strategy for cancer therapy. In our previous in vivo study, Nemopilema nomurai jellyfish venom (NnV) -treated HepG2 xenograft mice group showed that E-cadherin expression was strongly detected compared with non-treated groups. Therefore, this study aimed to determine whether NnV could inhibit the invasive and migratory abilities of HepG2 human hepatocellular carcinoma cells and to examine its effect on EMT...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425820/quercetin-restrains-tgf-%C3%AE-1-induced-epithelial-mesenchymal-transition-by-inhibiting-twist1-and-regulating-e-cadherin-expression
#15
Jihong Feng, Dalong Song, SiYuan Jiang, XiaoHui Yang, TingTing Ding, Hong Zhang, Junmin Luo, Jun Liao, Qian Yin
Emerging evidence has indicated that transforming growth factor-beta 1 (TGF-β1) induces the epithelial-mesenchymal transition (EMT) in cancer cells, thus promoting their motility and invasiveness. Quercetin, a member of the polyphenolic flavonoid family, has been reported to display anticancer activity against a broad range of cancer cell types. Indeed, numerous studies have shown the cancer preventive effects and molecular mechanisms of quercetin in vitro using diverse cell model systems. However, the potential effect of quercetin on EMT remains unclear...
February 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29420531/differential-roles-of-the-drosophila-emt-inducing-transcription-factors-snail-and-serpent-in-driving-primary-tumour-growth
#16
Kyra Campbell, Gaëlle Lebreton, Xavier Franch-Marro, Jordi Casanova
Several transcription factors have been identified that activate an epithelial-to-mesenchymal transition (EMT), which endows cells with the capacity to break through basement membranes and migrate away from their site of origin. A key program in development, in recent years it has been shown to be a crucial driver of tumour invasion and metastasis. However, several of these EMT-inducing transcription factors are often expressed long before the initiation of the invasion-metastasis cascade as well as in non-invasive tumours...
February 8, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29416940/tumor-associated-macrophages-remodeling-emt-and-predicting-survival-in-colorectal-carcinoma
#17
Si Li, Fangying Xu, Jing Zhang, Lili Wang, Yang Zheng, Xuesong Wu, Jing Wang, Qiong Huang, Maode Lai
The immune contexture, a composition of the tumor microenvironment, plays multiple important roles in cancer stem cell (CSC) and epithelial-mesenchymal transition (EMT), and hence critically influences tumor initiation, progression and patient outcome. Tumor-associated macrophages (TAMs) are abundant in immune contexture, however their roles in CSC, EMT and prognosis of colorectal cancer (CRC) have not been elucidated. In 419 colorectal carcinomas, immune cell types (CD68+ macrophages, CD3+ , CD4+ or CD8+ T lymphocytes, CD20+ B lymphocytes), EMT markers (E-cadherin and Snail) as well as the stem cell marker (CD44v6) were detected in tumor center (TC) and tumor invasive front (TF) respectively by immunohistochemistry...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29410023/histone-deacetylase-inhibitors-upregulate-snail-via-smad2-3-phosphorylation-and-stabilization-of-snail-to-promote-metastasis-of-hepatoma-cells
#18
Wei Xu, Hao Liu, Zhi-Gang Liu, Hong-Sheng Wang, Fan Zhang, Hao Wang, Ji Zhang, Jing-Jing Chen, Hong-Jun Huang, Yuan Tan, Meng-Ting Cao, Jun Du, Qiu-Gui Zhang, Guan-Min Jiang
Hepatocellular carcinoma (HCC) remains the third most common cause of cancer-related mortality. Resection and transplantation are the only curative treatments available, but are greatly hampered by high recurrence rates. Histone deacetylase inhibitors (HDACIs) are considered to be promising anticancer agents in drug development. Currently, four HDACIs have been granted Food and Drug Administration (FDA) approval for cancer. HDACIs have shown significant efficacy in hematological malignancies. However, they have limited effects in epithelial cell-derived cancers, including HCC, and the mechanisms of these are not elucidated...
January 30, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29393400/%C3%AE-%C3%A2-carotene-reverses-tobacco-smoke%C3%A2-induced-gastric-emt-via-notch-pathway-in-vivo
#19
Ling Lu, Jia Chen, Manli Li, Ling Tang, Rui Wu, Longtao Jin, Zhaofeng Liang
Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid present in fruits, vegetables and rice, suppresses cancer progression. In this investigation, we evaluated the regulatory role of Notch pathway in tobacco smoke‑mediated gastric EMT and the preventive effect of β‑carotene using a BALB/c mouse smoking model...
February 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29389061/the-mir-203-snai2-axis-regulates-prostate-tumor-growth-migration-angiogenesis-and-stemness-potentially-by-modulating-gsk-3%C3%AE-%C3%AE-catenin-signal-pathway
#20
Xinxin Tian, Fangfang Tao, Baotong Zhang, Jin-Tang Dong, Zhiqian Zhang
Dysregulation of microRNA expression plays a pivotal role in the initiation and progression of a variety of human carcinomas including prostate cancer. Our previous studies have demonstrated that the silence of miR-203 contributes to the invasiveness of malignant breast cancer cells by targeting SNAI2. However, the effects and underlying mechanisms of miR-203/SNAI2 axis in prostate cancer have not been elucidated. The aim of this study is to explore the effects of miR-203/SNAI2 axis on the biological characteristics of prostate carcinomas both in vitro and in vivo...
February 1, 2018: IUBMB Life
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