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Twist2 thyroid

Katrin-Janine Heiliger, Julia Hess, Donata Vitagliano, Paolo Salerno, Herbert Braselmann, Giuliana Salvatore, Clara Ugolini, Isolde Summerer, Tatjana Bogdanova, Kristian Unger, Gerry Thomas, Massimo Santoro, Horst Zitzelsberger
For an identification of novel candidate genes in thyroid tumourigenesis, we have investigated gene copy number changes in a Trk-T1 transgenic mouse model of thyroid neoplasia. For this aim, 30 thyroid tumours from Trk-T1 transgenics were investigated by comparative genomic hybridisation. Recurrent gene copy number alterations were identified and genes located in the altered chromosomal regions were analysed by Gene Ontology term enrichment analysis in order to reveal gene functions potentially associated with thyroid tumourigenesis...
June 2012: Endocrine-related Cancer
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