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JOURNAL ARTICLE
Mirthe Coenen, Floor A S de Kort, Nick A Weaver, Hugo J Kuijf, Hugo Paul Aben, Hee-Joon Bae, Régis Bordet, Christopher Lh Chen, Anna Dewenter, Thomas Doeven, Thibaut Dondaine, Marco Duering, Rong Fang, Ruben S van der Giessen, Jonguk Kim, Beom Joon Kim, Paul L M de Kort, Peter Koudstaal, Minwoo Lee, Jae-Sung Lim, Renaud Lopes, Robert J van Oostenbrugge, Julie Staals, Kyung-Ho Yu, Geert Jan Biessels, J Matthijs Biesbroek
BACKGROUND: Post-stroke cognitive impairment (PSCI) occurs in up to 50% of stroke survivors. Presence of pre-existing vascular brain injury, in particular the extent of white matter hyperintensities (WMH), is associated with worse cognitive outcome after stroke, but the role of WMH location in this association is unclear. AIM: We determined if WMH in strategic white matter tracts explain cognitive performance after stroke. METHODS: Individual patient data from 9 ischemic stroke cohorts with MRI were harmonized through the Meta VCI Map consortium...
April 23, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
#2
JOURNAL ARTICLE
Mehwish Ahmed, Autumn Pu, Kara Jencks, Shrinivas Bishu, Peter Higgins, William D Chey, Krishna Rao, Allen Lee
BACKGROUND: Many patients with quiescent inflammatory bowel disease (IBD) suffer from irritable bowel syndrome (IBS)-like symptoms. Although these symptoms cause significant reductions in quality of life, evidence-based treatments are lacking as risk factors and pathophysiology of these symptoms are not clearly defined. We aimed to identify risk factors for development of IBS-like symptoms in IBD patients with quiescent disease. METHODS: We performed a single-center retrospective cohort study of adults with IBD from 2015 to 2021...
April 23, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#3
JOURNAL ARTICLE
Belen Kornfeld, Lee Kyang, Ahmed Taha, Rachael McCloy, Vanessa Chin, Brett Leavers, Peter Floros, Peter Earls, Dion Forstner, Alfred Addison, Jullia Crawford, Richard Gallagher
No abstract text is available yet for this article.
April 23, 2024: Journal of Laryngology and Otology
#4
JOURNAL ARTICLE
Lara Struelens, Christelle Huet, David Broggio, Jérémie Dabin, Laurent Desorgher, Augusto Giussani, Wei Bo Li, Dietmar Nosske, Yi-Kang Lee, Lidia Cunha, Maria J R Carapinha, Mario Medvedec, Peter Covens
BACKGROUND: In order to ensure adequate radiation protection of critical groups such as staff, caregivers and the general public coming into proximity of nuclear medicine (NM) patients, it is necessary to consider the impact of the radiation emitted by the patients during their stay at the hospital or after leaving the hospital. Current risk assessments are based on ambient dose rate measurements in a single position at a specified distance from the patient and carried out at several time points after administration of the radiopharmaceutical to estimate the whole-body retention...
April 22, 2024: EJNMMI Physics
#5
JOURNAL ARTICLE
Adrian Wai Chan, Charles B Simone Ii, Joanne M van der Velden, Yvette van der Linden, Peter Hoskin, Jay Detsky, J Isabelle Choi, Shing Fung Lee, Henry C Y Wong, Emily J Martin, Srinivas Raman, Dirk Rades, Jonas Willmann, Agata Rembielak, Joanna Kazmierska, Emily R Keit, Gustavo Nader Marta, Vassilios Vassiliou, Sara Alcorn, Pierluigi Bonomo, Eva Oldenburger
No abstract text is available yet for this article.
April 17, 2024: Annals of Palliative Medicine
#6
JOURNAL ARTICLE
Angela Jerath, Christopher J D Wallis, Stephen Fremes, Vivek Rao, Terrence M Yau, Kiyan Heybati, Douglas S Lee, Harindra C Wijeysundera, Jason Sutherland, Peter C Austin, Duminda N Wijeysundera, Dennis T Ko
BACKGROUND: Research shows women experience higher mortality than men after cardiac surgery but information on sex-differences during postoperative recovery is limited. Days alive and out of hospital (DAH) combines death, readmission and length of stay, and may better quantify sex-differences during recovery. This main objective is to evaluate (i) how DAH at 30-days varies between sex and surgical procedure, (ii) DAH responsiveness to patient and surgical complexity, and (iii) longer-term prognostic value of DAH...
April 20, 2024: BMC Cardiovascular Disorders
#7
JOURNAL ARTICLE
Shelley Potter, Kerry Avery, Rosina Ahmed, Jana de Boniface, Sanjoy Chatterjee, David Dodwell, Peter Dubsky, Hiroji Iwata, Michael Jiang, Han-Byoel Lee, Mairead MacKenzie, Fiorita Poulakaki, Andrea L Richardson, Karla Sepulveda, Andrew Spillane, Alastair M Thompson, Gustavo Werutsky, Jean L Wright, Nicholas Zdenkowski, Katherine Cowan, Stuart McIntosh
INTRODUCTION: Neoadjuvant systemic anticancer therapy (neoSACT) is increasingly used in the treatment of early breast cancer. Response to therapy is prognostic and allows locoregional and adjuvant systemic treatments to be tailored to minimise morbidity and optimise oncological outcomes and quality of life. Accurate information about locoregional treatments following neoSACT is vital to allow the translation of downstaging benefits into practice and facilitate meaningful interpretation of oncological outcomes, particularly locoregional recurrence...
April 19, 2024: BMJ Open
#8
JOURNAL ARTICLE
Neil Chanchlani, Simeng Lin, Claire Bewshea, Benjamin Hamilton, Amanda Thomas, Rebecca Smith, Christopher Roberts, Maria Bishara, Rachel Nice, Charlie W Lees, Shaji Sebastian, Peter M Irving, Richard K Russell, Timothy J McDonald, James R Goodhand, Tariq Ahmad, Nicholas A Kennedy
BACKGROUND: We sought to report the effectiveness of infliximab and adalimumab over the first 3 years of treatment and to define the factors that predict anti-TNF treatment failure and the strategies that prevent or mitigate loss of response. METHODS: Personalised Anti-TNF therapy in Crohn's disease (PANTS) is a UK-wide, multicentre, prospective observational cohort study reporting the rates of effectiveness of infliximab and adalimumab in anti-TNF-naive patients with active luminal Crohn's disease aged 6 years and older...
April 16, 2024: Lancet. Gastroenterology & Hepatology
#9
JOURNAL ARTICLE
Mark S Lee, Peter J Tuohy, Caleb Y Kim, Philip P Yost, Katrina Lichauco, Heather L Parrish, Koenraad Van Doorslaer, Michael S Kuhns
CD4+ T cell activation is driven by five-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 complexes. CD4 is the coreceptor module. It reciprocally associates with TCR-CD3-pMHCII assemblies on the outside of a CD4+ T cells and with the Src kinase, LCK, on the inside. Previously, we reported that the CD4 transmembrane GGXXG and cytoplasmic juxtamembrane (C/F)CV+C motifs found in eutherian (placental mammal) CD4 have constituent residues that evolved under purifying selection (Lee et al...
April 19, 2024: ELife
#10
JOURNAL ARTICLE
Edward Griffin, Gawain Shirley, Xin Ying Lee, Susanne F Awad, Alok Tyagi, Peter J Goadsby
BACKGROUND: Migraine is a highly prevalent neurological disease with a substantial societal burden due to lost productivity. From a societal perspective, we assessed the cost-effectiveness of eptinezumab for the preventive treatment of migraine. METHODS: An individual patient simulation of discrete competing events was developed to evaluate eptinezumab cost-effectiveness compared to best supportive care for adults in the United Kingdom with ≥ 4 migraine days per month and prior failure of ≥ 3 preventive migraine treatments...
April 18, 2024: Journal of Headache and Pain
#11
JOURNAL ARTICLE
Daniel M Beswick, Christine M Liu, Jonathan B Overdevest, Anna Zemke, Aastha Khatiwada, David A Gudis, Jessa E Miller, Adam Kimple, Jeremy P Tervo, Emily DiMango, Jennifer L Goralski, Claire Keating, Brent Senior, Amanda L Stapleton, Patricia H Eshaghian, Jess C Mace, Karolin Markarian, Jeremiah A Alt, Todd E Bodner, Naweed I Chowdhury, Anne E Getz, Peter H Hwang, Ashoke Khanwalker, Jivianne T Lee, Douglas A Li, Meghan Norris, Jayakar V Nayak, Cameran Owens, Zara M Patel, Katie Poch, Rodney J Schlosser, Kristine A Smith, Timothy L Smith, Zachary M Soler, Jeffrey D Suh, Grant A Turner, Marilene B Wang, Milene T Saavedra, Jennifer L Taylor Cousar
OBJECTIVES: The 22-question SinoNasal Outcome Test (SNOT-22) assesses chronic rhinosinusitis (CRS) severity. We aimed to identify predictors of SNOT-22 score improvement following highly effective modulator therapy (HEMT) initiation and to corroborate the SNOT-22 minimal clinically important difference (MCID) in adults with cystic fibrosis (CF). METHODS: Prospective observational data was pooled from four studies across 10 US centers investigating people with CF (PwCF) and CRS...
April 18, 2024: Laryngoscope
#12
JOURNAL ARTICLE
Andrew D Harken, Naresh T Deoli, Citlali Perez Campos, Brian Ponnaiya, Guy Garty, Grace S Lee, Malte J Casper, Shikhar Dhingra, Wenze Li, Gary W Johnson, Sally A Amundson, Peter W Grabham, Elizabeth M C Hillman, David J Brenner
To improve particle radiotherapy, we need a better understanding of the biology of radiation effects, particularly in heavy ion radiation therapy, where global responses are observed despite energy deposition in only a subset of cells. Here, we integrated a high-speed swept confocally-aligned planar excitation (SCAPE) microscope into a focused ion beam irradiation platform to allow real-time 3D structural and functional imaging of living biological samples during and after irradiation. We demonstrate dynamic imaging of the acute effects of irradiation on 3D cultures of U87 human glioblastoma cells, revealing characteristic changes in cellular movement and intracellular calcium signaling following ionizing irradiation...
April 1, 2024: Biomedical Optics Express
#13
JOURNAL ARTICLE
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Tariq Ahmad, Dean Allerton, Michelle Bardgett, Emma Clark, Dawn Clewes, Cristina Cotobal Martin, Mary Doona, Jennifer A Doyle, Katherine Frith, Helen C Hancock, Ailsa L Hart, Victoria Hildreth, Peter M Irving, Sameena Iqbal, Ciara Kennedy, Andrew King, Sarah Lawrence, Charlie W Lees, Robert Lees, Laura Letchford, Trevor Liddle, James O Lindsay, Rebecca H Maier, John C Mansfield, Julian R Marchesi, Naomi McGregor, Rebecca E McIntyre, Jasmin Ostermayer, Tolulope Osunnuyi, Nick Powell, Natalie J Prescott, Jack Satsangi, Shriya Sharma, Tara Shrestha, Ally Speight, Michelle Strickland, James Ms Wason, Kevin Whelan, Ruth Wood, Gregory R Young, Xinyue Zhang, Miles Parkes, Christopher J Stewart, Luke Jostins-Dean, Christopher A Lamb
INTRODUCTION: Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient's quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients...
April 17, 2024: BMJ Open
#14
JOURNAL ARTICLE
Anahí Venzor Strader, Magda Sotz, Hannah N Gilbert, Ann C Miller, Anne Cc Lee, Peter Rohloff
INTRODUCTION: Neonatal mortality is a global public health challenge. Guatemala has the fifth highest neonatal mortality rate in Latin America, and Indigenous communities are particularly impacted. This study aims to understand factors driving neonatal mortality rates among Maya Kaqchikel communities. METHODS: We used sequential explanatory mixed methods. The quantitative phase was a secondary analysis of 2014-2016 data from the Global Maternal and Newborn Health Registry from Chimaltenango, Guatemala...
April 17, 2024: BMJ Global Health
#15
MULTICENTER STUDY
Hoang Van Phan, Alexandra Tsitsiklis, Cole P Maguire, Elias K Haddad, Patrice M Becker, Seunghee Kim-Schulze, Brian Lee, Jing Chen, Annmarie Hoch, Harry Pickering, Patrick van Zalm, Matthew C Altman, Alison D Augustine, Carolyn S Calfee, Steve Bosinger, Charles B Cairns, Walter Eckalbar, Leying Guan, Naresh Doni Jayavelu, Steven H Kleinstein, Florian Krammer, Holden T Maecker, Al Ozonoff, Bjoern Peters, Nadine Rouphael, Ruth R Montgomery, Elaine Reed, Joanna Schaenman, Hanno Steen, Ofer Levy, Joann Diray-Arce, Charles R Langelier
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated the impact of aging on host immune response in the blood and the upper airway, as well as the nasal microbiome in a prospective, multicenter cohort of 1031 vaccine-naïve patients hospitalized for COVID-19 between 18 and 96 years old. We performed mass cytometry, serum protein profiling, anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays, and blood and nasal transcriptomics...
April 17, 2024: Science Translational Medicine
#16
JOURNAL ARTICLE
David S Lee, Emma Y Travis, Susan K Wong, Marie-Ange Munyemana, Lauren Mueller, Cathryn Collopy Rowling, Jason T Rich, Patrik Pipkorn, Sidharth V Puram, Ryan S Jackson, Douglas R Adkins, Peter Oppelt, Wade L Thorstad, Cameron C Wick, Jose P Zevallos, Kate McClannahan, Angela L Mazul
PURPOSE: This study aims to characterize patterns in ototoxicity monitoring and identify potential barriers to audiologic follow-up. METHODS: We performed a single-institution retrospective cohort study on adult (≥ 18 years old) cancer patients treated with cisplatin from January 2014 to September 2021. Our primary outcomes were rates of baseline and post-treatment audiograms at the following time points: 3, 6, 12, and greater than 12 months...
April 17, 2024: Journal of Cancer Survivorship: Research and Practice
#17
JOURNAL ARTICLE
Javier Cortes, Eric P Winer, Oleg Lipatov, Seock-Ah Im, Anthony Gonçalves, Eva Muñoz-Couselo, Keun Seok Lee, Peter Schmid, Kenji Tamura, Laura Testa, Isabell Witzel, Shoichiro Ohtani, Stephanie Hund, Karina Kulangara, Vassiliki Karantza, Jaime A Mejia, Junshui Ma, Petar Jelinic, Lingkang Huang, Scott K Pruitt, Kenneth Emancipator
The efficacy of pembrolizumab monotherapy versus chemotherapy increased with increasing programmed death ligand 1 (PD-L1) expression, as quantified by combined positive score (CPS; PD-L1 expression on both tumour cells and immune cells) in patients with previously treated metastatic triple-negative breast cancer (mTNBC) in the phase 3 KEYNOTE-119 study. This exploratory analysis was conducted to determine whether the expression of PD-L1 on tumour cells contributes to the predictive value of PD-L1 CPS in mTNBC...
May 2024: Journal of Pathology. Clinical Research
#18
JOURNAL ARTICLE
Tijs J Hoogteijling, Mohammad Abu Hilal, Giuseppe Zimmitti, Davit L Aghayan, Andrew G R Wu, Federica Cipriani, Salvatore Gruttadauria, Olivier Scatton, Tran Cong Duy Long, Paulo Herman, Marco V Marino, Vincenzo Mazzaferro, Adrian K H Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee Chien Yong, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Alejandro Mejia, James O Park, Fernando Rotellar, Gi Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P Sutcliffe, Johann Pratschke, Chung-Ngai Tang, Charing C N Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, T Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Xiao Liang, Olivier Soubrane, Go Wakabayashi, Roberto I Troisi, Ho Seong Han, Tan To Cheung, Atsushi Sugioka, Safi Dokmak, Kuo Hsin Chen, Rong Liu, David Fuks, Wanguang Zhang, Luca Aldrighetti, Bjørn Edwin, Brian K P Goh
BACKGROUND: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. METHODS: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone...
April 2, 2024: European Journal of Surgical Oncology
#19
JOURNAL ARTICLE
Anthony D Jimenez, Margaret Gopaul, Hannah Asbell, Seyhmus Aydemir, Maysaa M Basha, Ayush Batra, Charlotte Damien, Gregory S Day, Onome Eka, Krista Eschbach, Safoora Fatima, Madeline C Fields, Brandon Foreman, Elizabeth E Gerard, Teneille E Gofton, Hiba A Haider, Stephen T Hantus, Sara Hocker, Amy Jongeling, Mariel Kalkach Aparicio, Padmaja Kandula, Peter Kang, Karnig Kazazian, Marissa A Kellogg, Minjee Kim, Jong Woo Lee, Lara V Marcuse, Christopher M McGraw, Wazim Mohamed, Janet Orozco, Cederic Pimentel, Vineet Punia, Alexandra M Ramirez, Claude Steriade, Aaron F Struck, Olga Taraschenko, Andrew K Treister, Ji Yeoun Yoo, Sahar Zafar, Daniel J Zhou, Deepti Zutshi, Nicolas Gaspard, Lawrence J Hirsch, Aurelie Hanin
Febrile infection-related epilepsy syndrome (FIRES) is a subset of new onset refractory status epilepticus (NORSE) that involves a febrile infection prior to the onset of the refractory status epilepticus. It is unclear whether FIRES and non-FIRES NORSE are distinct conditions. Here, we compare 34 patients with FIRES to 30 patients with non-FIRES NORSE for demographics, clinical features, neuroimaging, and outcomes. Because patients with FIRES were younger than patients with non-FIRES NORSE (median = 28 vs...
April 16, 2024: Epilepsia
#20
JOURNAL ARTICLE
Suryava Bhattacharya, Anthony N Price, Alena Uus, Helena S Sousa, Massimo Marenzana, Kathleen Colford, Peter Murkin, Maggie Lee, Lucilio Cordero-Grande, Rui Pedro A G Teixeira, Shaihan J Malik, Maria Deprez
PURPOSE: We propose a quantitative framework for motion-corrected T2 fetal brain measurements in vivo and validate the single-shot fast spin echo (SS-FSE) sequence to perform these measurements. METHODS: Stacks of two-dimensional SS-FSE slices are acquired with different echo times (TE) and motion-corrected with slice-to-volume reconstruction (SVR). The quantitative T2 maps are obtained by a fit to a dictionary of simulated signals. The sequence is selected using simulated experiments on a numerical phantom and validated on a physical phantom scanned on a 1...
April 16, 2024: Magnetic Resonance in Medicine
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