Meike Kespohl, Carl Christoph Goetzke, Nadine Althof, Clara Bredow, Nicolas Kelm, Sandra Pinkert, Thomas Bukur, Valesca Bukur, Kristin Grunz, Dilraj Kaur, Arnd Heuser, Michael Mülleder, Martina Sauter, Karin Klingel, Hartmut Weiler, Nikolaus Berndt, Matthias M Gaida, Wolfram Ruf, Antje Beling
BACKGROUND: Accumulating evidence implicates the activation of G-protein-coupled PARs (protease-activated receptors) by coagulation proteases in the regulation of innate immune responses. METHODS: Using mouse models with genetic alterations of the PAR2 signaling platform, we have explored contributions of PAR2 signaling to infection with coxsackievirus B3, a single-stranded RNA virus provoking multiorgan tissue damage, including the heart. RESULTS: We show that PAR2 activation sustains correlates of severe morbidity-hemodynamic compromise, aggravated hypothermia, and hypoglycemia-despite intact control of the virus...
February 22, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology