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JOURNAL ARTICLE
Frank Müller, Akhilesh Munagala, Michael J Bouthillier, Jesse I Skok, Harland Holman
BACKGROUND AND OBJECTIVES: Climate change is a major threat to the health of people worldwide. The health care system deals with the immediate health-related effects of climate change and, at the same time, is a major emitter of greenhouse gas. This study aimed to investigate (a) the awareness and perception of climate change among family medicine residency program directors, and (b) the state of climate change education in family medicine residency programs. METHODS: The Council of Academic Family Medicine Educational Research Alliance (CERA) conducted a cross-sectional survey of family medicine program directors in the United States in April 2023...
April 16, 2024: Family Medicine
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JOURNAL ARTICLE
Yuki Hitomi, Kazuko Ueno, Yoshihiro Aiba, Nao Nishida, Michihiro Kono, Mitsuki Sugihara, Yosuke Kawai, Minae Kawashima, Seik-Soon Khor, Kazuhiro Sugi, Hirotaka Kouno, Hiroshi Kouno, Atsushi Naganuma, Satoru Iwamoto, Shinji Katsushima, Kiyoshi Furuta, Toshiki Nikami, Tomohiko Mannami, Tsutomu Yamashita, Keisuke Ario, Tatsuji Komatsu, Fujio Makita, Masaaki Shimada, Noboru Hirashima, Shiro Yokohama, Hideo Nishimura, Rie Sugimoto, Takuya Komura, Hajime Ota, Motoyuki Kojima, Makoto Nakamuta, Naoyuki Fujimori, Kaname Yoshizawa, Yutaka Mano, Hironao Takahashi, Kana Hirooka, Satoru Tsuruta, Takeaki Sato, Kazumi Yamasaki, Yuki Kugiyama, Yasuhide Motoyoshi, Tomoyuki Suehiro, Akira Saeki, Kosuke Matsumoto, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Masahiro Ito, Kazuhito Kawata, Akinobu Takaki, Kuniaki Arai, Teruko Arinaga, Masanori Abe, Masaru Harada, Makiko Taniai, Mikio Zeniya, Hiromasa Ohira, Shinji Shimoda, Atsumasa Komori, Atsushi Tanaka, Kazuyoshi Ishigaki, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
BACKGROUND AIMS: Previous genome-wide association studies (GWAS) have indicated the involvement of shared (population-non-specific) and non-shared (population-specific) susceptibility genes in the pathogenesis of primary biliary cholangitis (PBC) among European and East-Asian populations. Although a meta-analysis of these distinct populations has recently identified more than 20 novel PBC susceptibility loci, analyses of population-specific genetic architecture are still needed for a more comprehensive search for genetic factors in PBC...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#3
JOURNAL ARTICLE
Kuan-Cheng Chen, Tien-Hsiang Wang, Cheng-Yuan Li, Yu-Jen Chiu
BACKGROUND: Tumor staging plays a pivotal role in melanoma management, where the depth of tumor invasion has been traditionally used as the cornerstone of staging. Paradoxically, the tumor diameter has not been integrated into the staging system. The aim of this study is to elucidate the clinical implications and prognostic value of tumor diameter in cutaneous melanoma, with a particular emphasis on the acral-melanoma predominant East Asian population, thus potentially enriching the clinical evaluation and treatment strategies for cutaneous melanoma...
April 23, 2024: World Journal of Surgery
#4
JOURNAL ARTICLE
Lais Ceschini Machado, Filipe Zimmer Dezordi, Gustavo Barbosa de Lima, Raul Emídio de Lima, Lilian Caroliny Amorim Silva, Leandro de Mattos Pereira, Alexandre Freitas da Silva, Antonio Marinho da Silva Neto, André Luiz Sá de Oliveira, Anderson da Costa Armstrong, Rômulo Pessoa-E-Silva, Rodrigo Moraes Loyo, Barbara de Oliveira Silva, Anderson Rodrigues de Almeida, Maira Galdino da Rocha Pitta, Francisco de Assis da Silva Santos, Marilda Mendonça Siqueira, Paola Cristina Resende, Edson Delatorre, Felipe Gomes Naveca, Fabio Miyajima, Tiago Gräf, Rodrigo Feliciano do Carmo, Michelly Cristiny Pereira, Tulio de Lima Campos, Matheus Filgueira Bezerra, Marcelo Henrique Santos Paiva, Gabriel da Luz Wallau
SARS-CoV-2 virus emerged as a new threat to humans and spread around the world, leaving a large death toll. As of January 2023, Brazil is among the countries with the highest number of registered deaths. Nonpharmacological and pharmacological interventions have been heterogeneously implemented in the country, which, associated with large socioeconomic differences between the country regions, has led to distinct virus spread dynamics. Here, we investigate the spatiotemporal dispersion of SARS-CoV-2 lineages in the Pernambuco state (Northeast Brazil) throughout the distinct epidemiological scenarios that unfolded in the first 2 years of the pandemic...
April 23, 2024: Microbiology Spectrum
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JOURNAL ARTICLE
Madhumitha Sentamilvannan, Abir Al-Dekany, Helena Niemi Eide, Anne Kveim Lie
BACKGROUND: Few studies have been conducted on young people's attitudes to the COVID-19 vaccine during the pandemic. We wished to examine how young people with an ethnic minority background decided whether to have the COVID-19 vaccine, based on the concept of vaccine hesitancy. Vaccine hesitancy involves uncertainty with regard to vaccination, irrespective of the decision taken. MATERIAL AND METHOD: Fourteen qualitative in-depth interviews with young people aged 16-25 years with an ethnic minority background and from the east side of Oslo were analysed and categorised into main themes...
April 23, 2024: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
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JOURNAL ARTICLE
Akira Hori
No abstract text is available yet for this article.
January 2024: Free neuropathology
#7
JOURNAL ARTICLE
Change Xiong, Ying Xia, Huihui Chen, Jing Cheng
Objective: The regional inequality of emergency medicine beds distribution has a great impact on population health as well as the accessibility of emergency services. This study aimed to explore the regional inequality of emergency medicine bed distribution and its influencing factors. Methods: The Gini coefficient and health resource agglomeration were used to analyze the regional inequality of emergency medicine beds distribution by area from 2012 to 2021 in China. Grey correlation models were used to explore the factors influencing the regional inequality of emergency medicine beds distribution...
2024: International Journal of Public Health
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JOURNAL ARTICLE
Mahamadou D Camara, Yitian Zhou, Taís Nóbrega De Sousa, José P Gil, Abdoulaye A Djimde, Volker M Lauschke
BACKGROUND: CYP2C8 is responsible for the metabolism of 5% of clinically prescribed drugs, including antimalarials, anti-cancer and anti-inflammatory drugs. Genetic variability is an important factor that influences CYP2C8 activity and modulates the pharmacokinetics, efficacy and safety of its substrates. RESULTS: We profiled the genetic landscape of CYP2C8 variability using data from 96 original studies and data repositories that included a total of 33,185 unrelated participants across 44 countries and 43 ethnic groups...
April 22, 2024: Human Genomics
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JOURNAL ARTICLE
Mandikudza Tembo, Victoria Simms, Helen A Weiss, Tsitsi Bandason, Nicol Redzo, Leyla Larsson, Ethel Dauya, Tafadzwa Nzanza, Pauline Ishumael, Nancy Gweshe, Rangarirai Nyamwanza, Precious Ndlovu, Sarah Bernays, Chido Dziva Chikwari, Constancia Vimbayi Mavodza, Jenny Renju, Suzanna C Francis, Rashida A Ferrand, Constance Mackworth-Young
BACKGROUND: Despite being integral to women's well-being, achieving good menstrual health (MH) remains a challenge. This study examined MH services uptake (including information, analgesics, and a choice of MH products - the menstrual cup and reusable pads) and sustained use of MH products within an integrated sexual and reproductive health intervention for young people in Zimbabwe. METHODS: This mixed-methods study was nested within a cluster randomised trial of integrated sexual and reproductive health services (CHIEDZA) for youth in three provinces (Harare, Mashonaland East, and Bulawayo)...
April 22, 2024: Reproductive Health
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JOURNAL ARTICLE
Yaqin Zhong, Xiaojun Guo, Yitong Liu, Yaning Wang, Yanan Wang, Yan Song, Rujian Lu
BACKGROUND: The aged people who live in nursing home are predicted to keep growing in the following decades. There are both quantitative imbalance and structural imbalance in the utilization of nursing homes in China. This study aimed to analyze old people's preference for nursing homes and help the government optimize resource allocation. METHODS: A discrete choice experiment (DCE) was conducted and six attributes of nursing homes including monthly fee, distance from home, geographical location, medical facilities, environment of nursing homes and nursing staff were determined...
April 22, 2024: BMC Nursing
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JOURNAL ARTICLE
Aljazi Al-Maraghi, Waleed Aamer, Mubarak Ziab, Elbay Aliyev, Najwa Elbashir, Sura Hussein, Sasirekha Palaniswamy, Dhullipala Anand, Donald R Love, Adrian Charles, Ammira A S Akil, Khalid A Fakhro
BACKGROUND: Renal tubular dysgenesis (RTD) is a severe disorder with poor prognosis significantly impacting the proximal tubules of the kidney while maintaining an anatomically normal gross structure. The genetic origin of RTD, involving variants in the ACE, REN, AGT, and AGTR1 genes, affects various enzymes or receptors within the Renin angiotensin system (RAS). This condition manifests prenatally with oligohydramninos and postnatally with persistent anuria, severe refractory hypotension, and defects in skull ossification...
April 22, 2024: BMC Nephrology
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JOURNAL ARTICLE
Anguach Shitie, Abebe Adimasu, Delelegn Tsegaye, Dagne Belete, Esuyawkal Mislu, Mandefro Assfaw, Wondimnew Gashaw Kettema
Breastfeeding is the cornerstone of child and maternal health. However, maternal breast problems during breastfeeding have been frequently reported as one of the reasons for early discontinuation of breastfeeding. Despite the importance of having knowledge on breast problems magnitude and its associated factors in the clinical practices and designing effective interventions, there is limited data on this topic. Therefore, this study aimed to assess the prevalence and associated factors of breast problem among postnatal lactating women in Legambo district, south wollo zone, North East Ethiopia, in 2022...
April 22, 2024: Scientific Reports
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JOURNAL ARTICLE
Zhihao Cao, Ruiyang Guo, Zhengyuan Fang, Zhiwen Wang, Yang Liu, Longhui Lin, Xiang Ji
We established a normal embryonic development table for the Anji salamander Hynobius amjiensis, a critically endangered tailed amphibian of the family Hynobiidae with a very limited distribution in East China, following the standards set by the early developmental table of vertebrates. Put together 32 embryonic stages for the Anji salamander was defined. The total embryonic period from oviposition to hatching is approximately 30 days at 9 °C. Stages 1 to 16 represent early development from cleavage to neurulation...
April 20, 2024: Developmental Biology
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JOURNAL ARTICLE
Jianrong Huang, Hongqiang Feng, V Alistair Drake, Don R Reynolds, Boya Gao, Fajun Chen, Guoyan Zhang, Junsheng Zhu, Yuebo Gao, Baoping Zhai, Guoping Li, Caihong Tian, Bo Huang, Gao Hu, Jason W Chapman
Long-distance migrations of insects contribute to ecosystem functioning but also have important economic impacts when the migrants are pests or provide ecosystem services. We combined radar monitoring, aerial sampling, and searchlight trapping, to quantify the annual pattern of nocturnal insect migration above the densely populated agricultural lands of East China. A total of ~9.3 trillion nocturnal insect migrants (15,000 t of biomass), predominantly Lepidoptera, Hemiptera, and Diptera, including many crop pests and disease vectors, fly at heights up to 1 km above this 600 km-wide region every year...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#15
JOURNAL ARTICLE
Simeon Lisovski, Bethany J Hoye, Jesse R Conklin, Phil F Battley, Richard A Fuller, Ken B Gosbell, Marcel Klaassen, Chengfa Benjamin Lee, Nicholas J Murray, Silke Bauer
The pace and scale of environmental change represent major challenges to many organisms. Animals that move long distances, such as migratory birds, are especially vulnerable to change since they need chains of intact habitat along their migratory routes. Estimating the resilience of such species to environmental changes assists in targeting conservation efforts. We developed a migration modeling framework to predict past (1960s), present (2010s), and future (2060s) optimal migration strategies across five shorebird species (Scolopacidae) within the East Asian-Australasian Flyway, which has seen major habitat deterioration and loss over the last century, and compared these predictions to empirical tracks from the present...
May 7, 2024: Proceedings of the National Academy of Sciences of the United States of America
#16
JOURNAL ARTICLE
Swati Sinha, Supriya Sharma, Kuldeep Singh, Deendayal Swarnkar, Naseem Ahmed, Priyanka Rajput, Bina Srivastava, Anup R Anvikar
BACKGROUND OBJECTIVES: Malaria due to Plasmodium falciparum (Pf) remains a major public threat in India. Artemisinin-based combination therapy (ACT) has been the country's first-line drug for uncomplicated Pf malaria. In 2013-2014, Artesunate plus sulfadoxine (AS+SP) was replaced by Artemether Lumefantrine (AL) as the first- line antimalarial in North East (NE) states of the country which are endemic for Pf malaria. Regular monitoring of antimalarial drugs is of utmost importance to achieve the goal of elimination...
January 1, 2024: Journal of Vector Borne Diseases
#17
JOURNAL ARTICLE
Elodie Ayangma Ndeme, Borris Rosnay Galani Tietcheu, Sylvie Agokeng Demanou, Dieudonne Pascal Chuisseu Djamen, Nicolas Njintang Yanou
BACKGROUNDS OBJECTIVES: Recent research in Cameroon reported several occurrences of dengue in urban settings, but concurrent dengue-malaria infection has received less attention, particularly in the East region. METHODS: A two-month cross-sectional and comparative research was performed at Bertoua Regional Hospital which included 50 malaria-positive participants and 90 non-malaria subjects. Participants were selected and provided with a questionnaire to collect sociodemographic data...
January 1, 2024: Journal of Vector Borne Diseases
#18
JOURNAL ARTICLE
Adam Gray, Sarah Douglas, Michael Tiller, Michael Bleakley
The Tennessee Bureau of Investigation (TBI) serves all 95 counties of Tennessee, but the data included in this article is primarily focused in upper east and east Tennessee (the parts of the state included in the eastern time zone). The forensic chemistry [seized drug] unit of the TBI began reporting nitazene analogues in late 2019. The primary analogues found in forensic chemistry cases were isotonitazene and metonitazene. After discussion and review of reporting statistics, the forensic toxicology unit began to monitor for these compounds in toxicology samples by using ions characteristic with the nitazene analogues...
April 22, 2024: Journal of Analytical Toxicology
#19
JOURNAL ARTICLE
Pramasari Edie Wijaya, Jane Fisher, Maggie Kirkman
Research on female genital cosmetic surgery usually comes from Anglophone countries. We investigated female genital cosmetic surgery in the predominantly Muslim South-East Asian country of Indonesia, aiming to identify the procedures offered by medical clinics on Instagram, how they are justified, and what they claim to achieve; and to understand what this means for women and their bodies. The 184 eligible posts from 19 clinics between 1 January to 31 March 2021 offered vaginoplasty, labiaplasty, hymenoplasty, and other procedures...
April 22, 2024: Culture, Health & Sexuality
#20
REVIEW
Apoorva, Sunit Kumar Singh
The emergence of highly zoonotic viral infections has propelled bat research forward. The viral outbreaks including Hendra virus, Nipah virus, Marburg virus, Ebola virus, Rabies virus, Middle East respiratory syndrome coronavirus, SARS-CoV and the latest SARS-CoV-2 have been epidemiologically linked to various bat species. Bats possess unique immunological characteristics that allow them to serve as a potential viral reservoir. Bats are also known to protect themselves against viruses and maintain their immunity...
April 22, 2024: Future Microbiology
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