keyword
MENU ▼
Read by QxMD icon Read
search

Ian C. Zachary

keyword
https://www.readbyqxmd.com/read/27886350/design-of-artificial-red-blood-cells-using-polymeric-hydrogel-microcapsules-hydrogel-stability-improvement-and-polymer-selection
#1
Wujie Zhang, Matthew J Bissen, Emily S Savela, Joshua N Clausen, Samantha J Fredricks, Xiaoru Guo, Zachary R Paquin, Ryan P Dohn, Ian J Pavelich, Alec L Polovchak, Michael J Wedemeyer, Brock E Shilling, Emily N Dufner, Anna C O'Donnell, Gerardo Rubio, Logan R Readnour, Tyler F Brown, Jung C Lee, Matey G Kaltchev, Junhong Chen, Charles S Tritt
PURPOSE: To improve the stability of pectin-oligochitosan hydrogel microcapsules under physiological conditions. METHODS: Two different approaches were examined: change of the cross-linker length and treatment of the hydrogel microcapsules with 150 Mm CaCl2. Replacement of pectin with alginate was also studied. RESULTS AND CONCLUSIONS: It was observed that the molecular weight of the cross-linker oligochiotsan had no significant improvement on microcapsule stability...
November 16, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27791098/aberrant-h3-3-dynamics-in-nac-promote-vulnerability-to-depressive-like-behavior
#2
Ashley E Lepack, Rosemary C Bagot, Catherine J Peña, Yong-Hwee E Loh, Lorna A Farrelly, Yang Lu, Samuel K Powell, Zachary S Lorsch, Orna Issler, Hannah M Cates, Carol A Tamminga, Henrik Molina, Li Shen, Eric J Nestler, C David Allis, Ian Maze
Human major depressive disorder (MDD), along with related mood disorders, is among the world's greatest public health concerns; however, its pathophysiology remains poorly understood. Persistent changes in gene expression are known to promote physiological aberrations implicated in MDD. More recently, histone mechanisms affecting cell type- and regional-specific chromatin structures have also been shown to contribute to transcriptional programs related to depressive behaviors, as well as responses to antidepressants...
October 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27743751/use-of-a-dermal-regeneration-template-wound-dressing-in-the-treatment-of-combat-related-upper-extremity-soft-tissue-injuries
#3
Ian L Valerio, Zachary Masters, Jonathan G Seavey, George C Balazs, Derek Ipsen, Scott M Tintle
PURPOSE: To assess the outcomes of treatment with a dermal regeneration template (DRT) in a cohort of combat casualties with severe upper extremity injuries. METHODS: Records of all active duty military patients treated with DRT at our institution between November 2009 and July 2013 were screened. Inclusion criteria were upper extremity open wounds sustained during combat, requiring split-thickness or full-thickness skin grafting for closure. The primary outcome measure was wound healing after the first attempt at definitive treatment (defined as the first application of split-thickness or full-thickness skin graft)...
October 12, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27635964/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guideline-on-posttreatment-follow-up-evaluation-of-patients-with-nonfunctioning-pituitary-adenomas
#4
Mateo Ziu, Ian F Dunn, Christopher Hess, Maria Fleseriu, Mary E Bodach, Luis M Tumialan, Nelson M Oyesiku, Kunal S Patel, Renzhi Wang, Bob S Carter, James Y Chen, Clark C Chen, Chirag G Patil, Zachary Litvack, Gabriel Zada, Manish K Aghi
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. Due to the lack of hormonal hypersecretion, posttreatment follow-up evaluation of NFPAs is challenging. OBJECTIVE: To create evidence-based guidelines in an attempt to formulate guidance for posttreatment follow-up in a consistent, rigorous, and cost-effective way. METHODS: An extensive literature search was performed. Only clinical articles describing postoperative follow-up of adult patients with NFPAs were included...
October 2016: Neurosurgery
https://www.readbyqxmd.com/read/27595995/palb2-chek2-and-atm-rare-variants-and-cancer-risk-data-from-cogs
#5
Melissa C Southey, David E Goldgar, Robert Winqvist, Katri Pylkäs, Fergus Couch, Marc Tischkowitz, William D Foulkes, Joe Dennis, Kyriaki Michailidou, Elizabeth J van Rensburg, Tuomas Heikkinen, Heli Nevanlinna, John L Hopper, Thilo Dörk, Kathleen Bm Claes, Jorge Reis-Filho, Zhi Ling Teo, Paolo Radice, Irene Catucci, Paolo Peterlongo, Helen Tsimiklis, Fabrice A Odefrey, James G Dowty, Marjanka K Schmidt, Annegien Broeks, Frans B Hogervorst, Senno Verhoef, Jane Carpenter, Christine Clarke, Rodney J Scott, Peter A Fasching, Lothar Haeberle, Arif B Ekici, Matthias W Beckmann, Julian Peto, Isabel Dos-Santos-Silva, Olivia Fletcher, Nichola Johnson, Manjeet K Bolla, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, Federik Marme, Barbara Burwinkel, Rongxi Yang, Pascal Guénel, Thérèse Truong, Florence Menegaux, Marie Sanchez, Stig Bojesen, Sune F Nielsen, Henrik Flyger, Javier Benitez, M Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menéndez, Hoda Anton-Culver, Susan Neuhausen, Argyrios Ziogas, Christina A Clarke, Hermann Brenner, Volker Arndt, Christa Stegmaier, Hiltrud Brauch, Thomas Brüning, Yon-Dschun Ko, Taru A Muranen, Kristiina Aittomäki, Carl Blomqvist, Natalia V Bogdanova, Natalia N Antonenkova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Amanda B Spurdle, kConFab Investigators, Els Wauters, Dominiek Smeets, Benoit Beuselinck, Giuseppe Floris, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Janet E Olson, Celine Vachon, Vernon S Pankratz, Catriona McLean, Christopher A Haiman, Brian E Henderson, Fredrick Schumacher, Loic Le Marchand, Vessela Kristensen, Grethe Grenaker Alnæs, Wei Zheng, David J Hunter, Sara Lindstrom, Susan E Hankinson, Peter Kraft, Irene Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Arja Jukkola-Vuorinen, Mervi Grip, Saila Kauppila, Peter Devilee, Robert A E M Tollenaar, Caroline Seynaeve, Antoinette Hollestelle, Montserrat Garcia-Closas, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Kamila Czene, Hatef Darabi, Mikael Eriksson, Diana M Eccles, Sajjad Rafiq, William J Tapper, Sue M Gerty, Maartje J Hooning, John W M Martens, J Margriet Collée, Madeleine Tilanus-Linthorst, Per Hall, Jingmei Li, Judith S Brand, Keith Humphreys, Angela Cox, Malcolm W R Reed, Craig Luccarini, Caroline Baynes, Alison M Dunning, Ute Hamann, Diana Torres, Hans Ulrich Ulmer, Thomas Rüdiger, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Susan Slager, Amanda E Toland, Christine B Ambrosone, Drakoulis Yannoukakos, Anthony Swerdlow, Alan Ashworth, Nick Orr, Michael Jones, Anna González-Neira, Guillermo Pita, M Rosario Alonso, Nuria Álvarez, Daniel Herrero, Daniel C Tessier, Daniel Vincent, Francois Bacot, Jacques Simard, Martine Dumont, Penny Soucy, Rosalind Eeles, Kenneth Muir, Fredrik Wiklund, Henrik Gronberg, Johanna Schleutker, Børge G Nordestgaard, Maren Weischer, Ruth C Travis, David Neal, Jenny L Donovan, Freddie C Hamdy, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Daniel J Schaid, Joseph L Kelley, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Katja Butterbach, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Stefan P Renner, Arndt Hartmann, Alexander Hein, Matthias Ruebner, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Sandrina Lambretchs, Jennifer A Doherty, Mary Anne Rossing, Stefan Nickels, Ursula Eilber, Shan Wang-Gohrke, Kunle Odunsi, Lara E Sucheston-Campbell, Grace Friel, Galina Lurie, Jeffrey L Killeen, Lynne R Wilkens, Marc T Goodman, Ingo Runnebaum, Peter A Hillemanns, Liisa M Pelttari, Ralf Butzow, Francesmary Modugno, Robert P Edwards, Roberta B Ness, Kirsten B Moysich, Andreas du Bois, Florian Heitz, Philipp Harter, Stefan Kommoss, Beth Y Karlan, Christine Walsh, Jenny Lester, Allan Jensen, Susanne Krüger Kjaer, Estrid Høgdall, Bernard Peissel, Bernardo Bonanni, Loris Bernard, Ellen L Goode, Brooke L Fridley, Robert A Vierkant, Julie M Cunningham, Melissa C Larson, Zachary C Fogarty, Kimberly R Kalli, Dong Liang, Karen H Lu, Michelle A T Hildebrandt, Xifeng Wu, Douglas A Levine, Fanny Dao, Maria Bisogna, Andrew Berchuck, Edwin S Iversen, Jeffrey R Marks, Lucy Akushevich, Daniel W Cramer, Joellen Schildkraut, Kathryn L Terry, Elizabeth M Poole, Meir Stampfer, Shelley S Tworoger, Elisa V Bandera, Irene Orlow, Sara H Olson, Line Bjorge, Helga B Salvesen, Anne M van Altena, Katja K H Aben, Lambertus A Kiemeney, Leon F A G Massuger, Tanja Pejovic, Yukie Bean, Angela Brooks-Wilson, Linda E Kelemen, Linda S Cook, Nhu D Le, Bohdan Górski, Jacek Gronwald, Janusz Menkiszak, Claus K Høgdall, Lene Lundvall, Lotte Nedergaard, Svend Aage Engelholm, Ed Dicks, Jonathan Tyrer, Ian Campbell, Iain McNeish, James Paul, Nadeem Siddiqui, Rosalind Glasspool, Alice S Whittemore, Joseph H Rothstein, Valerie McGuire, Weiva Sieh, Hui Cai, Xiao-Ou Shu, Rachel T Teten, Rebecca Sutphen, John R McLaughlin, Steven A Narod, Catherine M Phelan, Alvaro N Monteiro, David Fenstermacher, Hui-Yi Lin, Jennifer B Permuth, Thomas A Sellers, Y Ann Chen, Ya-Yu Tsai, Zhihua Chen, Aleksandra Gentry-Maharaj, Simon A Gayther, Susan J Ramus, Usha Menon, Anna H Wu, Celeste L Pearce, David Van Den Berg, Malcolm C Pike, Agnieszka Dansonka-Mieszkowska, Joanna Plisiecka-Halasa, Joanna Moes-Sosnowska, Jolanta Kupryjanczyk, Paul Dp Pharoah, Honglin Song, Ingrid Winship, Georgia Chenevix-Trench, Graham G Giles, Sean V Tavtigian, Doug F Easton, Roger L Milne
BACKGROUND: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk as high as those associated with rare BRCA2 mutations. We aimed to estimate the relative risks associated with specific rare variants in PALB2, CHEK2 and ATM via a multicentre case-control study. METHODS: We genotyped 10 rare mutations using the custom iCOGS array: PALB2 c...
September 5, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27522950/adverse-event-reporting-in-clinical-trials-of-intravenous-and-invasive-pain-treatments-an-acttion-systematic-review
#6
Mark R Williams, Andrew McKeown, Zachary Pressman, Matthew Hunsinger, Kendrick Lee, Paul Coplan, Ian Gilron, Nathaniel P Katz, Michael P McDermott, Srinivasa N Raja, Bob A Rappaport, Michael C Rowbotham, Dennis C Turk, Robert H Dworkin, Shannon M Smith
: Thorough assessment and reporting of adverse events (AEs) facilitates a detailed understanding of a treatment's risk-benefit profile. Although the Consolidated Standards of Reporting Trials (CONSORT) 2004 statement provides recommendations regarding AE reporting, adherence to these standards is often inadequate. We investigated AE reporting in clinical trials of intravenous and invasive pain treatments published in 6 major anesthesiology and pain journals between 2000-2003 and 2006-2012...
August 11, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27293031/imatinib-and-nilotinib-increase-glioblastoma-cell-invasion-via-abl-independent-stimulation-of-p130cas-and-fak-signalling
#7
Antonina Frolov, Ian M Evans, Ningning Li, Kastytis Sidlauskas, Ketevan Paliashvili, Nicola Lockwood, Angela Barrett, Sebastian Brandner, Ian C Zachary, Paul Frankel
Imatinib was the first targeted tyrosine kinase inhibitor to be approved for clinical use, and remains first-line therapy for Philadelphia chromosome (Ph+)-positive chronic myelogenous leukaemia. We show that treatment of human glioblastoma multiforme (GBM) tumour cells with imatinib and the closely-related drug, nilotinib, strikingly increases tyrosine phosphorylation of p130Cas, focal adhesion kinase (FAK) and the downstream adaptor protein paxillin (PXN), resulting in enhanced cell migration and invasion...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27181059/circuit-wide-transcriptional-profiling-reveals-brain-region-specific-gene-networks-regulating-depression-susceptibility
#8
Rosemary C Bagot, Hannah M Cates, Immanuel Purushothaman, Zachary S Lorsch, Deena M Walker, Junshi Wang, Xiaojie Huang, Oliver M Schlüter, Ian Maze, Catherine J Peña, Elizabeth A Heller, Orna Issler, Minghui Wang, Won-Min Song, Jason L Stein, Xiaochuan Liu, Marie A Doyle, Kimberly N Scobie, Hao Sheng Sun, Rachael L Neve, Daniel Geschwind, Yan Dong, Li Shen, Bin Zhang, Eric J Nestler
Depression is a complex, heterogeneous disorder and a leading contributor to the global burden of disease. Most previous research has focused on individual brain regions and genes contributing to depression. However, emerging evidence in humans and animal models suggests that dysregulated circuit function and gene expression across multiple brain regions drive depressive phenotypes. Here, we performed RNA sequencing on four brain regions from control animals and those susceptible or resilient to chronic social defeat stress at multiple time points...
June 1, 2016: Neuron
https://www.readbyqxmd.com/read/27103444/peri-and-postnatal-effects-of-prenatal-adenoviral-vegf-gene-therapy-in-growth-restricted-sheep
#9
David J Carr, Jacqueline M Wallace, Raymond P Aitken, John S Milne, John F Martin, Ian C Zachary, Donald M Peebles, Anna L David
Uterine artery (UtA) adenovirus (Ad) vector-mediated overexpression of vascular endothelial growth factor (VEGF) enhances uterine blood flow in normal sheep pregnancy and increases fetal growth in the overnourished adolescent sheep model of fetal growth restriction (FGR). Herein, we examined its impact on gestation length, neonatal survival, early postnatal growth and metabolism. Singleton-bearing ewes were evenly allocated to receive Ad.VEGF-A165 (5 × 10(10) particles/ml, 10 ml, n = 17) or saline (10 ml, n = 16) injected into each UtA at laparotomy (0...
June 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27044325/vegf-a-isoforms-program-differential-vegfr2-signal-transduction-trafficking-and-proteolysis
#10
Gareth W Fearnley, Gina A Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A Mughal, Shervanthi Homer-Vanniasinkam, Mark T Kearney, Ian C Zachary, Darren C Tomlinson, Michael A Harrison, Stephen B Wheatcroft, Sreenivasan Ponnambalam
Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can elicit differential signal transduction and endothelial responses. However, it is unclear how such cellular responses are controlled by isoform-specific VEGF-A-VEGFR2 complexes. Increasingly, there is the realization that the membrane trafficking of receptor-ligand complexes influences signal transduction and protein turnover...
2016: Biology Open
https://www.readbyqxmd.com/read/26991001/structural-studies-of-neuropilin-2-reveal-a-zinc-ion-binding-site-remote-from-the-vascular-endothelial-growth-factor-binding-pocket
#11
Yi-Chun Isabella Tsai, Constantina Fotinou, Rohini Rana, Tamas Yelland, Paul Frankel, Ian Zachary, Snezana Djordjevic
Neuropilin-2 is a transmembrane receptor involved in lymphangiogenesis and neuronal development. In adults, neuropilin-2 and its homologous protein neuropilin-1 have been implicated in cancers and infection. Molecular determinants of the ligand selectivity of neuropilins are poorly understood. We have identified and structurally characterized a zinc ion binding site on human neuropilin-2. The neuropilin-2-specific zinc ion binding site is located near the interface between domains b1 and b2 in the ectopic region of the protein, remote from the neuropilin binding site for its physiological ligand, i...
May 2016: FEBS Journal
https://www.readbyqxmd.com/read/26845077/teaching-hospital-cataract-surgical-outcomes-in-adelaide-australia
#12
Neeranjali S Jain, Ying Liu, Sarah B Wang, Adarsh George, Matt Govendir, Zachary E McPherson, Ashish Agar, Ian C Francis
No abstract text is available yet for this article.
February 4, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/26728149/pur-alpha-regulates-cytoplasmic-stress-granule-dynamics-and-ameliorates-fus-toxicity
#13
J Gavin Daigle, Karthik Krishnamurthy, Nandini Ramesh, Ian Casci, John Monaghan, Kevin McAvoy, Earl W Godfrey, Dianne C Daniel, Edward M Johnson, Zachary Monahan, Frank Shewmaker, Piera Pasinelli, Udai Bhan Pandey
Amyotrophic lateral sclerosis is characterized by progressive loss of motor neurons in the brain and spinal cord. Mutations in several genes, including FUS, TDP43, Matrin 3, hnRNPA2 and other RNA-binding proteins, have been linked to ALS pathology. Recently, Pur-alpha, a DNA/RNA-binding protein was found to bind to C9orf72 repeat expansions and could possibly play a role in the pathogenesis of ALS. When overexpressed, Pur-alpha mitigates toxicities associated with Fragile X tumor ataxia syndrome (FXTAS) and C9orf72 repeat expansion diseases in Drosophila and mammalian cell culture models...
April 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/26681342/use-of-a-bioartificial-dermal-regeneration-template-for-skin-restoration-in-combat-casualty-injuries
#14
Jonathan G Seavey, Zachary A Masters, George C Balazs, Scott M Tintle, Jennifer Sabino, Mark E Fleming, Ian L Valerio
Military personnel who survive combat injuries frequently have large soft tissue wounds complicated by concomitant injuries and contamination. These devastating wounds present a therapeutic challenge to not only restore the protective skin barrier but also to preserve tendon and muscle excursion, provide protective padding around nerves and restore adequate joint motion. Accordingly, regenerative medicine modalities that can accomplish these goals are of great interest. The use of bioartificial dermal regeneration templates (DRT), such as Integra DRT (Integra Lifesciences Corporation, Plainsboro, NJ, USA), in the management of complex soft tissue injuries has an important role in the reconstruction of war wounds...
January 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/26627644/transformation-and-patterning-of-supermicelles-using-dynamic-holographic-assembly
#15
Oliver E C Gould, Huibin Qiu, David J Lunn, John Rowden, Robert L Harniman, Zachary M Hudson, Mitchell A Winnik, Mervyn J Miles, Ian Manners
Although the solution self-assembly of block copolymers has enabled the fabrication of a broad range of complex, functional nanostructures, their precise manipulation and patterning remain a key challenge. Here we demonstrate that spherical and linear supermicelles, supramolecular structures held together by non-covalent solvophobic and coordination interactions and formed by the hierarchical self-assembly of block copolymer micelle and block comicelle precursors, can be manipulated, transformed and patterned with mediation by dynamic holographic assembly (optical tweezers)...
December 2, 2015: Nature Communications
https://www.readbyqxmd.com/read/26601949/1%C3%AE-25-dihydroxyvitamin-d3-regulates-mitochondrial-oxygen-consumption-and-dynamics-in-human-skeletal-muscle-cells
#16
COMPARATIVE STUDY
Zachary C Ryan, Theodore A Craig, Clifford D Folmes, Xuewei Wang, Ian R Lanza, Niccole S Schaible, Jeffrey L Salisbury, K Sreekumaran Nair, Andre Terzic, Gary C Sieck, Rajiv Kumar
Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal failure, where concentrations of the active vitamin D3 metabolite, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), are low. To evaluate the mechanism of action of 1α,25(OH)2D3 in skeletal muscle, we examined mitochondrial oxygen consumption, dynamics, and biogenesis and changes in expression of nuclear genes encoding mitochondrial proteins in human skeletal muscle cells following treatment with 1α,25(OH)2D3. The mitochondrial oxygen consumption rate (OCR) increased in 1α,25(OH)2D3-treated cells...
January 15, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26538021/sex-linked-skeletal-phenotype-of-lysyl-oxidase-like-1-mutant-mice
#17
Loai Alsofi, Eileen Daley, Ian Hornstra, Elise F Morgan, Zachary D Mason, Jesus F Acevedo, R Ann Word, Louis C Gerstenfeld, Philip C Trackman
Lysyl oxidases are required for collagen and elastin cross-linking and extracellular matrix maturation including in bone. The lysyl oxidase family consists of lysyl oxidase (LOX) and 4 isoforms (LOXL1-4). Here we investigate whether deletion of LOXL1, which has been linked primarily to elastin maturation, leads to skeletal abnormalities. Left femurs (n = 8), L5 vertebrae (n = 8), and tibiae (n = 8) were analyzed by micro-computed tomography in 13-week-old wild-type (WT) and LOXL1-/- male and female mice. Right femurs (n = 8) were subjected to immunohistochemistry for LOXL1, and histochemical/histology analyses of osteoclasts and growth plates...
February 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/26410366/neuropilins-1-and-2-mediate-neointimal-hyperplasia-and-re-endothelialization-following-arterial-injury
#18
Caroline Pellet-Many, Vedanta Mehta, Laura Fields, Marwa Mahmoud, Vanessa Lowe, Ian Evans, Jorge Ruivo, Ian Zachary
AIMS: Neuropilins 1 and 2 (NRP1 and NRP2) play crucial roles in endothelial cell migration contributing to angiogenesis and vascular development. Both NRPs are also expressed by cultured vascular smooth muscle cells (VSMCs) and are implicated in VSMC migration stimulated by PDGF-BB, but it is unknown whether NRPs are relevant for VSMC function in vivo. We investigated the role of NRPs in the rat carotid balloon injury model, in which endothelial denudation and arterial stretch induce neointimal hyperplasia involving VSMC migration and proliferation...
November 1, 2015: Cardiovascular Research
https://www.readbyqxmd.com/read/26158448/genome-modeling-system-a-knowledge-management-platform-for-genomics
#19
Malachi Griffith, Obi L Griffith, Scott M Smith, Avinash Ramu, Matthew B Callaway, Anthony M Brummett, Michael J Kiwala, Adam C Coffman, Allison A Regier, Ben J Oberkfell, Gabriel E Sanderson, Thomas P Mooney, Nathaniel G Nutter, Edward A Belter, Feiyu Du, Robert L Long, Travis E Abbott, Ian T Ferguson, David L Morton, Mark M Burnett, James V Weible, Joshua B Peck, Adam Dukes, Joshua F McMichael, Justin T Lolofie, Brian R Derickson, Jasreet Hundal, Zachary L Skidmore, Benjamin J Ainscough, Nathan D Dees, William S Schierding, Cyriac Kandoth, Kyung H Kim, Charles Lu, Christopher C Harris, Nicole Maher, Christopher A Maher, Vincent J Magrini, Benjamin S Abbott, Ken Chen, Eric Clark, Indraniel Das, Xian Fan, Amy E Hawkins, Todd G Hepler, Todd N Wylie, Shawn M Leonard, William E Schroeder, Xiaoqi Shi, Lynn K Carmichael, Matthew R Weil, Richard W Wohlstadter, Gary Stiehr, Michael D McLellan, Craig S Pohl, Christopher A Miller, Daniel C Koboldt, Jason R Walker, James M Eldred, David E Larson, David J Dooling, Li Ding, Elaine R Mardis, Richard K Wilson
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides detailed tracking of samples and data coupled with reliable and repeatable analysis pipelines. The GMS also serves as a platform for bioinformatics development, allowing a large team to collaborate on data analysis, or an individual researcher to leverage the work of others effectively within its data management system...
July 2015: PLoS Computational Biology
https://www.readbyqxmd.com/read/26158114/variability-and-accuracy-of-different-software-packages-for-dynamic-susceptibility-contrast-magnetic-resonance-imaging-for-distinguishing-glioblastoma-progression-from-pseudoprogression
#20
Zachary S Kelm, Panagiotis D Korfiatis, Ravi K Lingineni, John R Daniels, Jan C Buckner, Daniel H Lachance, Ian F Parney, Rickey E Carter, Bradley J Erickson
Determining whether glioblastoma multiforme (GBM) is progressing despite treatment is challenging due to the pseudoprogression phenomenon seen on conventional MRIs, but relative cerebral blood volume (CBV) has been shown to be helpful. As CBV's calculation from perfusion-weighted images is not standardized, we investigated whether there were differences between three FDA-cleared software packages in their CBV output values and subsequent performance regarding predicting survival/progression. Forty-five postradiation therapy GBM cases were retrospectively identified as having indeterminate MRI findings of progression versus pseudoprogression...
April 2015: Journal of Medical Imaging
keyword
keyword
999
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"