Fabio Vivarelli, Camilla Morosini, Laura Rullo, Loredana Maria Losapio, Antonio Lacorte, Stefano Sangiorgi, Severino Ghini, Ivan Fagiolino, Paola Franchi, Marco Lucarini, Sanzio Candeletti, Donatella Canistro, Patrizia Romualdi, Moreno Paolini
Although the Food and Drug Administration has authorized the marketing of "heat-not-burn" (HnB) electronic cigarettes as a modified risk tobacco product (MRTP), toxicological effects of HnB smoke exposure on the brain are still unexplored. Here, paramagnetic resonance of the prefrontal cortex (PFC) of HnB-exposed rats shows a dramatic increase in reactive radical species (RRS) yield coupled with an inflammatory response mediated by NF-κB-target genes including TNF-α, IL-1β, and IL-6 and the downregulation of peroxisome proliferator-activated receptor (PPAR) alpha and gamma expression...
2024: Frontiers in Pharmacology