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https://www.readbyqxmd.com/read/28527149/characterisation-of-drug-related-problems-and-associated-factors-at-a-clinical-pharmacist-service-na%C3%A3-ve-hospital-in-northern-sweden
#1
Cecilia Peterson, Maria Gustafsson
BACKGROUND: Polypharmacy and increased sensitivity to side effects cause adverse drug events, drug-drug interactions and medication errors in the elderly. OBJECTIVE: The objective of this study was to investigate the prevalence and type of drug-related problems and associated factors among patients admitted to a clinical pharmacist service-naïve medical ward in an inland hospital in northern Sweden. METHODS: During September-November 2015 and February-April 2016, clinical pharmacists working as part of a ward team on the medical ward conducted 103 medication reviews...
May 19, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28527108/increased-expression-of-brain-derived-neurotrophic-factor-transcripts-i-and-vi-camp-response-element-binding-and-glucocorticoid-receptor-in-the-cortex-of-patients-with-temporal-lobe-epilepsy
#2
G A Martínez-Levy, L Rocha, F Rodríguez-Pineda, M A Alonso-Vanegas, A Nani, R M Buentello-García, M Briones-Velasco, D San-Juan, J Cienfuegos, C S Cruz-Fuentes
A body of evidence supports a relevant role of brain-derived neurotrophic factor (BDNF) in temporal lobe epilepsy (TLE). Magnetic resonance data reveal that the cerebral atrophy extends to regions that are functionally and anatomically connected with the hippocampus, especially the temporal cortex. We previously reported an increased expression of BDNF messenger for the exon VI in the hippocampus of temporal lobe epilepsy patients compared to an autopsy control group. Altered levels of this particular transcript were also associated with pre-surgical use of certain psychotropic...
May 19, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28521790/unintentional-drowning-role-of-medicinal-drugs-and-alcohol
#3
Tuulia Pajunen, Erkki Vuori, Frank F Vincenzi, Pirjo Lillsunde, Gordon Smith, Philippe Lunetta
BACKGROUND: Alcohol is a well-known risk factor in unintentional drownings. Whereas psychotropic drugs, like alcohol, may cause psychomotor impairment and affect cognition, no detailed studies have focused on their association with drowning. Finland provides extensive post-mortem toxicological data for studies on drowning because of its high medico-legal autopsy rates. METHODS: Drowning cases, 2000 through 2009, for which post-mortem toxicological analysis was performed, came from the database of the Toxicological Laboratory, Department of Forensic Medicine, University of Helsinki, using the ICD-10 nature-of-injury code T75...
May 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28521676/the-ultimate-outlier-transitional-care-for-persons-with-dementia-and-bpsd
#4
Jiska Cohen-Mansfield, Colleen A Ray, Tasmia Hai, Cristina Marcu, Brandy L Callahan, Morris Freedman
BACKGROUND: Transitional care units aim to assist caregivers who cannot manage the care for persons with dementia who manifest behavioral and psychological symptoms of dementia (BPSD). However, there is a dearth in research on such care units. OBJECTIVE: The current study reviewed one specialized transitional unit to better understand the characteristics of the persons with dementia and behavioral symptoms entering such unit. The study also looked at the change in terms of (a) BPSD, (b) use of psychotropic medications and (c) function of the patients in this unit...
May 15, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28516426/characterization-of-medication-use-in-a-multicenter-sample-of-pediatric-inpatients-with-autism-spectrum-disorder
#5
Logan K Wink, Ernest V Pedapati, Ryan Adams, Craig A Erickson, Kahsi A Pedersen, Eric M Morrow, Desmond Kaplan, Matthew Siegel
Nearly 11% of youth with Autism Spectrum Disorder (ASD) undergo psychiatric hospitalization, and 65% are treated with psychotropic medication. Here we characterize psychotropic medication usage in subjects enrolled in the Autism Inpatient Collection. Participant psychotropic medication usage rates topped 90% at admission and discharge, though there was a decline at 2-month follow-up. Antipsychotics, ADHD medications, and sleep aids were the most commonly reported classes of medications. The impact of age, gender, and non-verbal IQ on medication usage rates was minimal, though age and IQ may play a role in prescribing practices...
May 17, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28515818/pharmacogenomic-testing-for-psychotropic-medication-selection-a-systematic-review-of-the-assurex-genesight-psychotropic-test
#6
(no author information available yet)
BACKGROUND: A large proportion of the Ontario population lives with a diagnosed mental illness. Nearly 5% of Ontarians have major depressive disorder, and another 5% have another type of depressive disorder, bipolar disorder, schizophrenia, anxiety, or some other disorder not otherwise specified. Medications are commonly used to treat mental illness, but choosing the right medication for each patient is challenging, and more than 40% of patients discontinue their medication within 90 days because of adverse effects or lack of response...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28515116/antidepressants-depression-and-venous-thromboembolism-risk-large-prospective-study-of-uk-women
#7
Lianne Parkin, Angela Balkwill, Siân Sweetland, Gillian K Reeves, Jane Green, Valerie Beral
BACKGROUND: Some investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and with use of antidepressant drugs. We explored these associations in a large prospective study of UK women. METHODS AND RESULTS: The Million Women Study recruited 1.3 million women through the National Health Service Breast Screening Programme in England and Scotland. Three years after recruitment, women were sent a second questionnaire that enquired about depression and regular use of medications in the previous 4 weeks...
May 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28514486/efficacy-of-42-pharmacologic-cotreatment-strategies-added-to-antipsychotic-monotherapy-in-schizophrenia-systematic-overview-and-quality-appraisal-of-the-meta-analytic-evidence
#8
Christoph U Correll, Jose M Rubio, Gabriella Inczedy-Farkas, Michael L Birnbaum, John M Kane, Stefan Leucht
Importance: Limited treatment responses in schizophrenia prompted the testing of combining an antipsychotic drug treatment with a second psychotropic medication. A comprehensive evaluation of the efficacy of multiple medication combinations is missing. Objective: To summarize and compare the meta-analytically determined efficacy of pharmacologic combination strategies of antipsychotic drugs in adults with schizophrenia. Data Sources: Systematic search of PubMed and PsycInfo until May 13, 2016...
May 17, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28513794/psychotropic-drug-use-among-older-adults-prevalence-and-associated-factors
#9
Mariza Miranda Abi-Ackel, Maria Fernanda Lima-Costa, Érico Castro-Costa, Antônio Ignácio de Loyola
Objective: Investigating the prevalence of psychotropic drug use among older adults and factors associated with it. Methods: This study was based on the Belo Horizonte Metropolitan Area Health Survey, conducted in 2003. It involved 1,635 elderly (60 years or older) citizens, who were residents of cities within the Belo Horizonte Metropolitan Area and were selected using complex randomize sampling. Logistic regression models were used to identify factors associated with psychotropic drug use, with a 5...
January 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28512768/nursing-home-prices-and-quality-of-care-evidence-from-administrative-data
#10
Arndt R Reichert, Magdalena A Stroka
There is widespread concern about the quality of care in nursing homes. On the basis of administrative data of a large health insurance fund, we investigate whether nursing home prices are associated with relevant quality of care indicators at the resident level. Our results indicate negative associations between price and both inappropriate and psychotropic medication. In contrast, we do not find any relationship between the price and impairments of physical health.
May 17, 2017: Health Economics
https://www.readbyqxmd.com/read/28512767/duration-of-major-and-minor-depressive-episodes-and-associated-risk-indicators-in-a-psychiatric-epidemiological-cohort-study-of-the-general-population
#11
M Ten Have, B W J H Penninx, M Tuithof, S van Dorsselaer, M Kleinjan, J Spijker, R de Graaf
OBJECTIVE: Hardly any studies exist on the duration of major depressive disorder (MDD) and factors that explain variations in episode duration that lack biases. This limits clinical decision-making and leaves patients wondering when they will recover. METHOD: Data were used from the Netherlands Mental Health Survey and Incidence Study-2, a psychiatric epidemiological cohort study among a nationally representative adult population. Respondents with a newly originated depressive episode were selected: 286 MDD and 107 minor depressive disorder (MinDD) cases...
May 16, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28511829/suicidal-behaviors-in-the-dermatology-patient
#12
Madhulika A Gupta, Daiana R Pur, Branka Vujcic, Aditya K Gupta
An assessment of suicidal behaviors in the dermatology patient may be necessary in several situations: (1) in the presence of psychiatric comorbidity (major depressive disorder, body dysmorphic disorder, substance use disorder, posttraumatic stress disorder), encountered in up to 30% of dermatology patients; (2) when dermatologic symptoms ("dysmorphophobia," dermatitis artefacta) represent psychiatric pathologic conditions; (3) when psychosocial stressors (bereavement, interpersonal violence) increase the risk of suicidal behavior and exacerbate stress-reactive dermatoses (psoriasis, acne); (4) in the presence of high disease burden (chronicity, increased disease severity); (5) in instances of significant pruritus or chronic sleep disruption; (6) in the presence of facial lesions or facial scarring; (7) when social exclusion or feelings of alienation arise secondary to the skin disorder; (8) with use of medications (retinoids, biologics) for which suicidal behavior has been implicated as a possible side effect; and (9) when treating psychiatric patients experiencing a serious reaction to psychotropic medications (eg, Stevens-Johnson syndrome and anticonvulsants)...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28506184/complications-of-psychotropic-and-pain-medications-in-an-ultrarapid-metabolizer-patient-at-the-upper-1-of-cytochrome-p450-cyp450-function-quantified-by-combinatorial-cyp450-genotyping
#13
Gualberto Ruaño, Karen Larsen, Mohan Kocherla, James Samuel Graydon, Jonathan Kost
A 44-year-old Caucasian woman presented with a history of empirical treatment with 20 pain and psychotropic medications, as well as dual comorbidity of intractable pain and depression. A multiple gain-of-function profile in the CYP450 family of cytochrome P450 (CYP450) drug metabolism isoenzymes was discovered. The patient was a homozygote of suprafunctional alleles for both CYP2D6 ((*)35/(*)35) and CYP2C19 ((*)17/(*)17) genes and functional alleles for CYP2C9 ((*)1/(*)1), which account for aggregate drug metabolism function at the upper 1% of the population...
May 16, 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28505935/re-sexual-dysfunction-among-females-receiving-psychotropic-medication-a%C3%A2-hospital-based-cross-sectional-study
#14
Allen D Seftel
No abstract text is available yet for this article.
June 2017: Journal of Urology
https://www.readbyqxmd.com/read/28505500/increase-in-the-prescription-rate-of-antidepressants-after-the-sewol-ferry-disaster-in-ansan-south-korea
#15
Kyu-Man Han, Kyoung-Hoon Kim, Mikyung Lee, Sang-Min Lee, Young-Hoon Ko, Jong-Woo Paik
BACKGROUND: Previous pharmaco-epidemiological studies have reported increases in the prescription of psychotropic medications after a disaster, reflecting post-disaster changes in psychiatric conditions and mental health service utilization. We investigated changes in the prescription of psychotropic medications in the Danwon district of Ansan city (Ansan Danwon) compared to a control community before and after the Sewol Ferry disaster on April 16, 2014. METHODS: Data was collected from the Korean Health Insurance Review and Assessment Service database...
May 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28504976/ce-antipsychotic-medications
#16
Donna Sabella
An evidence-based review of the mechanisms of action, adverse effects, and contraindications of these commonly used drugs. ABSTRACT: Antipsychotic medications are primarily used to manage various symptoms of psychosis. In recent years, more adults-and teenagers-are taking at least one type of psychotropic medication, the majority of which are prescribed by primary care and family physicians. Because nurses are now caring for people of varying ages, and with varying diagnoses, who are taking these types of medications, they need to develop a working knowledge of the agents available and know when it's appropriate to prescribe them for mental health disorders as well as for disorders unrelated to mental health...
May 11, 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28499520/prevalence-and-predictors-of-low-sexual-desire-sexually-related-personal-distress-and-hypoactive-sexual-desire-dysfunction-in-a-community-based-sample-of-midlife-women
#17
Roisin Worsley, Robin J Bell, Pragya Gartoulla, Susan R Davis
BACKGROUND: Low desire is the most common sexual problem in women at midlife. Prevalence data are limited by lack of validated instruments or exclusion of un-partnered or sexually inactive women. AIM: To document the prevalence of and factors associated with low desire, sexually related personal distress, and hypoactive sexual desire dysfunction (HSDD) using validated instruments. METHODS: Cross-sectional, nationally representative, community-based sample of 2,020 Australian women 40 to 65 years old...
May 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28496420/impaired-maintenance-of-interpersonal-synchronization-in-musical-improvisations-of-patients-with-borderline-personality-disorder
#18
Katrien Foubert, Tom Collins, Jos De Backer
Borderline personality disorder (BPD) is a serious and complex mental disorder with a lifetime prevalence of 5.9%, characterized by pervasive difficulties with emotion regulation, impulse control, and instability in interpersonal relationships and self-image. Impairments in interpersonal functioning have always been a prominent characteristic of BPD, indicating a need for research to identify the specific interpersonal processes that are problematic for diagnosed individuals. Previous research has concentrated on self-report questionnaires, unidirectional tests, and experimental paradigms wherein the exchange of social signals between individuals was not the focus...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28491214/prescribing-pattern-of-psychotropic-medications-in-child-psychiatric-practice-in-a-mental-referral-hospital-in-botswana
#19
Anthony Olashore, James Ayugi, Philip Opondo
INTRODUCTION: There is a growing preference for psycho-pharmacological therapy over non-pharmacological care. The prescription pattern and the choice of psychotropic medications vary in different settings. Whilst newer agents and rational prescribing are favored in the more specialized settings, the pattern remains unclear in less specialized units, largely due to lack of data. The aims were to conduct a treatment audit in the only mental referral hospital in Botswana, which is a non-specialized child and adolescent care setting and see how it conforms to best practice...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28490035/clinical-pharmacopsychology-conceptual-foundations-and-emerging-tasks
#20
Giovanni A Fava, Elena Tomba, Per Bech
The aim of this critical review was to outline emerging trends and perspectives of clinical pharmacopsychology, an area of clinical psychology that is concerned with the psychological effects of medications. The historical development of clinical pharmacopsychology is outlined, with discussion of its most representative expressions and reference to current challenges of clinical research, with particular reference to clinimetrics. The domains of clinical pharmacopsychology encompass the clinical benefits of psychotropic drugs, the characteristics that predict responsiveness to treatment, the vulnerabilities induced by treatment (side effects, behavioral toxicity, iatrogenic comorbidity), and the interactions between drug treatment and psychological variables...
2017: Psychotherapy and Psychosomatics
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