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pulmonary lymphoepithelioma-like carcinoma

Gul Ege Aktas, Nuray Can, Selin Soyluoglu Demir, Ali Sarıkaya
A 69-year-old male smoker was referred to (18)F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) with the indication of a suspicious solitary pulmonary nodule. FDG PET/CT determined a 2.5 × 2-cm soft-tissue lesion (SUVmax, 16.2) with spiculated margins in the hilum of the right lung. A 1-cm diameter lymphadenopathy on the right hilum with an SUVmax of 3.2 was also determined. Transbronchial biopsy of the right hilar lymphadenopathy did not reveal any malignant features in histopathologic examination, and it was determined to be reactive...
March 2017: Nuclear Medicine and Molecular Imaging
Chun-Yu Lin, Ying-Jen Chen, Meng-Heng Hsieh, Chih-Wei Wang, Yueh-Fu Fang
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is rare, with better clinical outcomes than other lung cancers. However, reports on advanced LELC characteristics and prognosis are lacking. METHODS: This retrospective study included adults diagnosed with advanced LELC (at least stage IIIA) between January 2003 and December 2015. Clinical characteristics, treatment modalities, and outcomes were recorded. RESULTS: Study population comprised 23 patients with a mean age of 63...
January 2017: Journal of Thoracic Disease
Naoko Ose, Teruka Kawai, Daisuke Ishida, Yuko Kobori, Yukiyasu Takeuchi, Hidetoshi Senba
A pulmonary lymphoepithelioma-like carcinoma (PLELC) is similar to a lymphoepithelioma, a subtype of nasopharyngeal carcinoma and commonly associated with Epstein-Barr virus infection which is a rare tumour and classified in the group of "other and unclassified carcinoma" in the latest 2015 World Health Organization (WHO) classification. Some reports of lymphoepithelioma-like carcinoma (LELC) have noted an epidermal growth factor receptor (EGFR) mutation, whereas none have noted a mutation of the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene...
November 2016: Respirology Case Reports
Wen-Yang Jiang, Rui Wang, Xu-Feng Pan, Yu-Zhou Shen, Tian-Xiang Chen, Yun-Hai Yang, Jin-Cheng Shao, Lei Zhu, Bao-Hui Han, Jun Yang, Heng Zhao
BACKGROUND: Lymphoepithelioma-like carcinoma (LELC) is a rare form of non-small cell lung carcinoma. The current study focused on its clinicopathological features and potential factors influencing the prognosis. METHODS: The statistical analysis was based on the clinicopathological records and the prognosis of 43 LELC patients, analyzed by Kaplan-Meier method, Log-rank test, and COX regression analysis. RESULTS: The patients' average age was 57...
September 2016: Journal of Thoracic Disease
Ryoko Oi, Hisashi Saji, Hideki Marushima, Ichiro Maeda, Masayuki Takagi, Haruhiko Nakamura
Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare malignant tumour with histological features similar to undifferentiated nasopharyngeal carcinoma. A close association is known to exist between pulmonary LELC and Epstein-Barr virus infection in Southeast Asian countries. We report a 69-year-old man with pulmonary LELC arising from a thin-walled cavity with a smooth inner surface and characterized by an unexpectedly rapid progression.
September 2016: Respirology Case Reports
Mouna Mlika, Sadok Boudaya, Emna Braham, Fatma Chermiti, Ahmed Sayi, Adel Marghli, Faouzi El Mezni
BACKGROUND: Thymic carcinomas are rare tumors with a challenging diagnosis. Our aim was to report our 17-year experience of these tumors and to highlight the challenges encountered and the main differential diagnoses ruled out. METHODS: We studied 12 (92%) men and 1 (7.7%) woman with a mean age of 37 years (range 15-60 years). All patients were symptomatic, with chest pain representing the most frequent symptom. Radiology revealed anterior mediastinal masses in all cases, with either infiltration of the adjacent organs or pulmonary parenchymal metastases...
May 2016: Asian Cardiovascular & Thoracic Annals
Zhichao Lin, Dongrong Situ, Xiangzhen Chang, Wenhua Liang, Meiling Zhao, Chengjie Cai, Yang Liu, Jianxing He
OBJECTIVES: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare but unique subtype of non-small-cell lung cancer (NSCLC). Our study aimed to evaluate clinicopathological characteristics and the value of surgical treatment for LELC and explore the relevant prognostic factors in a relatively large cohort. METHODS: We retrospectively reviewed the medical records of 39 lung LELC patients who underwent pulmonary resection with curative intent between January 2009 and December 2013...
July 2016: Interactive Cardiovascular and Thoracic Surgery
Jiaxi He, Jianfei Shen, Hui Pan, Jun Huang, Wenhua Liang, Jianxing He
BACKGROUND: Pulmonary lymphoepithelioma-like carcinoma (LELC) is one of the rare histological non-small cell lung cancers. Only a few case reports have been published. The knowledge of its characteristics and prognosis in western population is limited. Based on the data of the Surveillance, Epidemiology, and End Results database (SEER), an analysis was performed to fill the gap of our knowledge. METHODS: Characteristics, treatment and outcomes of all pulmonary LELC patients was extracted both from the SEER database from 1973 to 2011 using SEER*Stat 8...
December 2015: Journal of Thoracic Disease
S Bertz, A Hartmann, R Knüchel-Clarke, N T Gaisa
Bladder cancer shows rare variants and special subtypes with diverse prognostic importance and therefore may necessitate different therapeutic approaches. For pathologists it is important to histologically diagnose and specify such variants. Nested variants of urothelial carcinoma with inconspicuous, well-formed tumor cell nests present with an aggressive course. The plasmacytoid variant, which morphologically resembles plasma cells is associated with a shorter survival time and a high frequency of peritoneal metastasis...
February 2016: Der Pathologe
Liang Wang, Yongbin Lin, Qingqing Cai, Hao Long, Yu Zhang, Tiehua Rong, Guowei Ma, Ying Liang
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a distinct rare subtype of lung cancer. The prevalence of anaplastic lymphoma kinase (ALK) rearrangement and epidermal growth factor receptor (EGFR) mutation in primary pulmonary LELC had not been thoroughly investigated. METHODS: We investigated a cohort of 42 patients with primary pulmonary LELC and genotyped for ALK rearrangement and EGFR mutation. ALK rearrangement was detected by fluorescence in situ hybridization (FISH)...
September 2015: Journal of Thoracic Disease
Wenfeng Fang, Shaodong Hong, Nan Chen, Xiaobo He, Jianhua Zhan, Tao Qin, Ting Zhou, Zhihuang Hu, Yuxiang Ma, Yuanyuan Zhao, Ying Tian, Yunpeng Yang, Cong Xue, Yanna Tang, Yan Huang, Hongyun Zhao, Li Zhang
BACKGROUD: Programmed cell death-ligand 1 (PD-L1) and driver mutations are commonly seen in non-small-cell lung cancer (NSCLC). However, the prevelance of PD-L1 over-expression and its prognostic value in Epstein-Barr virus (EBV) associated pulmonary lymphoepithelioma-like carcinoma (LELC) remains poorly understood. METHODS: A total of 214 NSCLC patients and 113 surgically treated pulmonary LELC patients were included. Paraffin-embedded tumor sections were stained with PD-L1 antibody...
October 20, 2015: Oncotarget
Li Jiang, Liang Wang, Peng-Fei Li, Xin-Ke Zhang, Jie-Wei Chen, Hui-Juan Qiu, Xiao-Dong Wu, Bei Zhang
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare subtype of non-small cell lung cancer (NSCLC), and no effective treatments have been defined for advanced disease. Programmed cell death-ligand 1 (PD-L1) is expressed in a group of cancers that may be suitable targets for specific immunotherapy. METHODS: This study investigated the expression and clinical value of PD-L1 in pulmonary LELC. Seventy-nine patients with pulmonary LELC were investigated...
2015: OncoTargets and Therapy
Yo Kawaguchi, Takuya Fujita, Jun Hanaoka
The spontaneous regression of lung cancer is extremely rare. We encountered a case of a 70-year-old man with pulmonary lymphoepithelioma-like carcinoma that regressed without receiving anticancer therapy. The patient had depression during tumor regression, however, and was treated with a serotonin-selective reuptake inhibitor. On histologic examination, CD3(+), CD4(+), and CD8(+) lymphocytes were found to have infiltrated around the tumor. Thus, the serotonin-selective reuptake inhibitor may have activated these lymphocytes to cause spontaneous tumor regression...
June 2015: Annals of Thoracic Surgery
Liang Wang, Wen Long, Peng-fei Li, Yong-bin Lin, Ying Liang
Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer. In this study, we retrospectively reviewed the data from 74 consecutive patients with pulmonary LELC and investigated the prognostic value of pretreatment monocyte-to-lymphocyte ratio (MLR). The cut-off value determined by ROC curve for MLR was 0.262. According to this cut-off value, 36 (48.6%) patients had lower MLR value (<0.262) at diagnosis. There was no significant correlation between MLR level and gender, age, smoking history, stage, and lactate dehydrogenase (LDH) level...
2015: PloS One
Yih-Leong Chang, Ching-Yao Yang, Mong-Wei Lin, Chen-Tu Wu, Pan-Chyr Yang
OBJECTIVES: Programmed cell death-ligand 1 (PD-L1) and driver mutations are found in non-small cell lung cancers (NSCLCs) and may be suitable targets for specific therapies, but their roles in lymphoepithelioma-like carcinoma (LELC) of the lung are unclear. MATERIALS AND METHODS: Sixty-six patients with pulmonary LELCs were investigated. Paraffin-embedded tumor sections were stained with PD-L1 antibody. Tumors with moderate-to-strong membrane staining in ≥5% of tumor cells were positive for PD-L1 overexpression...
June 2015: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Yasha Liang, Cheng Shen, Guowei Che, Fengming Luo
A mass was detected in the middle lobe of the right lung of a 58-year-old female. The patient did not present any symptoms and was a nonsmoker. Diagnostic evaluation revealed squamous metaplasia in the middle lobe of the right lung. During surgery, a tumor was identified, which was diagnosed as a lymphoepithelioma-like carcinoma (LELC). LELCs have been mainly reported in the Asian population and are associated with the Epstein-Barr virus (EBVs), while they are not associated with smoking. Squamous metaplasia, which is the basis of squamous cell carcinoma, differs from LELC in the therapeutic methods used and the prognostic evaluation...
April 2015: Oncology Letters
Nobuhiro Kushida, Takashi Kushakabe, Masao Kataoka, Shin Kumagai, Ken Aikawa, Yoshiyuki Kojima
Lymphoepithelioma is a malignant epithelial tumor in the nasopharynx characterized by prominent lymphoid infiltration. Carcinomas that resemble lymphoepitheliomas have been called lymphoepithelioma-like carcinomas and have been reported in other organs. A tumor in the bladder is categorized by the percentage of the total area occupied by the lymphoepithelioma-like carcinoma pattern, with the prognosis dependent on the percentage. We present an 81-year-old man with stage 3 chronic obstructive pulmonary disease and a history of aortic aneurysm repair...
January 2015: Case Reports in Oncology
Yoshinori Hiramatsu, Takehiko Okagawa
A 66-year-old male was referred to our hospital due to an abnormal chest shadow in the left lung detected on a medical examination. Chest computed tomography(CT) revealed a round mass of 40 mm in diameter in the left S10. Positron emission tomography (PET) scan showed fluorodeoxy glucose (FDG) accumulation and surgical biopsy was done. The intraoperative frozen histopathological diagnosis was mucosal associated lymphoid tissue( MALT) lymphoma or pseudoinflammatory tumor. By postoperative pathology, the mass was finally diagnosis as lymphoepithelioma-like carcinoma (LELC) of the lung, pT2aN0M0 stage I B...
November 2014: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Mahmut Ozsahin, René-Olivier Mirimanoff, Juliette Thariat, Xu Shan Sun, Banu Atalar, Yasmin Lassen-Ramshad, Gamze Ugurluer, Sunil Krishnan, Christopher Hallemeier, Paul Van Houtte, Marco Krengli, Lan Jun Zhang, Kenneth Chang, Ryan Funk, Jessica Rooney, Robert C Miller
The Rare Cancer Network (RCN) was formed in the early 1990's to create a global network that could pool knowledge and resources in the studies of rare malignancies whose infrequency prevented both their study with prospective clinical trials. To date, the RCN has initiated 74 studies resulting in 46 peer reviewed publications. The First International Symposium of the Rare Cancer Network took place in Nice in March of 2014. Status updates and proposals for new studies were heard for fifteen topics. Ongoing studies continue for cardiac sarcomas, thyroid cancers, glomus tumors, and adult medulloblastomas...
July 30, 2014: Rare Tumors
Yan Gu, Wei Zhang, Hua Du, Guihua Wei, Xiuhua Fu
No abstract text is available yet for this article.
2014: Chinese Medical Journal
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