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https://www.readbyqxmd.com/read/29117779/refractory-chronic-lupus-peritonitis-resolved-by-multitargeted-therapy
#1
S Matsuda, S Yoshida, E Nakamura, T Takeuchi, S Makino
No abstract text is available yet for this article.
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29109286/circadian-clock-cryptochrome-proteins-regulate-autoimmunity
#2
Qi Cao, Xuan Zhao, Jingwen Bai, Sigal Gery, Haibo Sun, De-Chen Lin, Qi Chen, Zhengshan Chen, Lauren Mack, Henry Yang, Ruishu Deng, Xianping Shi, Ling-Wa Chong, Han Cho, Jianjun Xie, Quan-Zhen Li, Markus Müschen, Annette R Atkins, Christopher Liddle, Ruth T Yu, Serhan Alkan, Jonathan W Said, Ye Zheng, Michael Downes, Ronald M Evans, H Phillip Koeffler
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum IgG concentrations, serum antinuclear antibodies, and precipitation of IgG, IgM, and complement 3 in glomeruli and massive infiltration of leukocytes into the lungs and kidneys. Flow cytometry of lymphoid organs revealed decreased pre-B cell numbers and a higher percentage of mature recirculating B cells in the bone marrow, as well as increased numbers of B2 B cells in the peritoneal cavity of Cry DKO mice...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28696256/a-novel-subset-of-anti-inflammatory-cd138-macrophages-is-deficient-in-mice-with-experimental-lupus
#3
Shuhong Han, Haoyang Zhuang, Stepan Shumyak, Jingfan Wu, Hui Li, Li-Jun Yang, Westley H Reeves
Dead cells accumulating in the tissues may contribute to chronic inflammation. We examined the cause of impaired apoptotic cell clearance in human and murine lupus. Dead cells accumulated in bone marrow from lupus patients but not from nonautoimmune patients undergoing myeloablation, where they were efficiently removed by macrophages (MΦ). Impaired apoptotic cell uptake by MΦ also was seen in mice treated i.p. with pristane (develop lupus) but not mineral oil (MO) (do not develop lupus). The inflammatory response to both pristane and MO rapidly depleted resident (Tim4(+)) large peritoneal MΦ...
August 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28274793/pkk-deficiency-in-b-cells-prevents-lupus-development-in-sle-lupus-mice
#4
D Oleksyn, J Zhao, A Vosoughi, J C Zhao, R Misra, A P Pentland, D Ryan, J Anolik, C Ritchlin, J Looney, A P Anandarajah, G Schwartz, L M Calvi, M Georger, C Mohan, I Sanz, L Chen
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that can result in damage to multiple organs. It is well documented that B cells play a critical role in the development of the disease. We previously showed that protein kinase C associated kinase (PKK) is required for B1 cell development as well as for the survival of recirculating mature B cells and B-lymphoma cells. Here, we investigated the role of PKK in lupus development in a lupus mouse model...
May 2017: Immunology Letters
https://www.readbyqxmd.com/read/28068928/newly-recognized-cerebral-infarctions-on-postmortem-imaging-a-report-of-three-cases-with-systemic-infectious-disease
#5
Sakon Noriki, Kazuyuki Kinoshita, Kunihiro Inai, Toyohiko Sakai, Hirohiko Kimura, Takahiro Yamauchi, Masayuki Iwano, Hironobu Naiki
BACKGROUND: Postmortem imaging (PMI) refers to the imaging of cadavers by computed tomography (CT) and/or magnetic resonance imaging (MRI). Three cases of cerebral infarctions that were not found during life but were newly recognized on PMI and were associated with severe systemic infections are presented. CASE PRESENTATIONS: An 81-year-old woman with a pacemaker and slightly impaired liver function presented with fever. Imaging suggested interstitial pneumonia and an iliopsoas abscess, and blood tests showed liver dysfunction and disseminated intravascular coagulation (DIC)...
January 10, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/27768123/milk-fat-globule-egf-factor-8-suppresses-the-aberrant-immune-response-of-systemic-lupus-erythematosus-derived-neutrophils-and-associated-tissue-damage
#6
Wei Huang, Jiyuan Wu, Huiqin Yang, Yin Xiong, Rui Jiang, Tianpen Cui, Duyun Ye
Abnormal features of the systemic lupus erythematosus (SLE)-derived neutrophils, promoted aberrant immune response, have inspired new studies of the induction of autoimmunity and the development of organ damage in SLE. In this study, we explore the effect of milk fat globule-EGF factor 8 (MFG-E8) on the aberrant nitrification features in pristane-induced lupus. SLE patients and mice with pristane-induced lupus develop autoantibodies associated with MFG-E8 overproduction. However, the deletion of MFG-E8 leads to uncontrolled early pulmonary and peritoneal inflammation and tissue damage in mice with pristane-induced lupus...
February 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27504333/association-of-systemic-lupus-erythematosus-and-beta-thalassaemia-trait-a-case-report
#7
Bimal Kumar Agrawal, Saurabh Marwaha, Mini Bhatnagar, Shabir A Parry, Usha Agrawal
Systemic Lupus Erythematosus (SLE) is a multisystem chronic inflammatory disease of autoimmune aetiology. It has a predilection for female gender and presence of photosensitive rash over the sun exposed area gives a clue to the diagnosis. Diagnosis in a male patient with atypical manifestations is unusual and difficult. A 25-year-old male presented with fever, fatigue, vomiting, abdominal pain and loss of weight. He had sustained injury on his right arm following which he developed abscess at the trauma site and severe anaemia...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27354219/tlr9-deficiency-leads-to-accelerated-renal-disease-and-myeloid-lineage-abnormalities-in-pristane-induced-murine-lupus
#8
Lukas Bossaller, Anette Christ, Karin Pelka, Kerstin Nündel, Ping-I Chiang, Catherine Pang, Neha Mishra, Patricia Busto, Ramon G Bonegio, Reinhold Ernst Schmidt, Eicke Latz, Ann Marshak-Rothstein
Systemic lupus erythematosus (SLE) is a chronic, life-threatening autoimmune disorder, leading to multiple organ pathologies and kidney destruction. Analyses of numerous murine models of spontaneous SLE have revealed a critical role for endosomal TLRs in the production of autoantibodies and development of other clinical disease manifestations. Nevertheless, the corresponding TLR9-deficient autoimmune-prone strains consistently develop more severe disease pathology. Injection of BALB/c mice with 2,6,10,14-tetramethylpentadecane (TMPD), commonly known as pristane, also results in the development of SLE-like disease...
August 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27055518/gastrointestinal-manifestations-in-systemic-lupus-erythematosus
#9
M Fawzy, A Edrees, H Okasha, A El Ashmaui, G Ragab
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by multisystem involvement, including the gastrointestinal (GI) tract. There is a significant variation in the clinical presentation and severity of GI disorders. When GI symptoms present as the initial manifestation of SLE, there is likely to be a delay in the diagnosis. The cause of these GI manifestations in SLE may be the disease, or the side effects of medications, or infections. In this study we investigated the GI manifestations in a group of SLE patients...
November 2016: Lupus
https://www.readbyqxmd.com/read/26829196/endoscopic-ultrasound-guided-transgastric-drainage-of-a-complex-multiloculated-peritoneal-fluid-collection-as-rare-complication-of-lupus-peritonitis
#10
Farid Jalali, Jason Samarasena, John G Lee
No abstract text is available yet for this article.
2016: Endoscopy
https://www.readbyqxmd.com/read/26773156/c1q-modulates-the-response-to-tlr7-stimulation-by-pristane-primed-macrophages-implications-for-pristane-induced-lupus
#11
Francesco Carlucci, Attia Ishaque, Guang Sheng Ling, Marta Szajna, Ann Sandison, Philippe Donatien, H Terence Cook, Marina Botto
The complement component C1q is known to play a controversial role in the pathogenesis of systemic lupus erythematosus, but the underlying mechanisms remain poorly understood. Intraperitoneal injection of pristane induces a lupus-like syndrome whose pathogenesis implicates the secretion of type I IFN by CD11b(+) Ly6C(high) inflammatory monocytes in a TLR7-dependent fashion. C1q was also shown to influence the secretion of IFN-α. In this study, we explored whether C1q deficiency could affect pristane-induced lupus...
February 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26770333/a20-overexpression-alleviates-pristine-induced-lupus-nephritis-by-inhibiting-the-nf-%C3%AE%C2%BAb-and-nlrp3-inflammasome-activation-in-macrophages-of-mice
#12
Min Li, Xiaowei Shi, Tian Qian, Jian Li, Zhiqiang Tian, Bing Ni, Fei Hao
BACKGROUND: Lupus nephritis is an autoimmune inflammatory disease and urgently needs effective anti-inflammation therapies. A20, tumor necrosis factor alpha induced protein 3 (TNFAIP3), is a key negative regulator of inflammation, however whether A20 can regulate lupus nephritis has not been clarified. This study aimed at investigating the potential therapeutic effect of A20 on renal inflammation in mouse pristine model oflupus. METHODOLOGY/PRINCIPAL FINDINGS: Female BALB/c mice were intraperitoneally injected with pristine to establish lupus renal injury...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26765478/increased-risks-of-spontaneous-bacterial-peritonitis-and-interstitial-lung-disease-in-primary-biliary-cirrhosis-patients-with-concomitant-sj%C3%A3-gren-syndrome
#13
Chun-Ting Chen, Yu-Chen Tseng, Chih-Wei Yang, Hsuan-Hwai Lin, Peng-Jen Chen, Tien-Yu Huang, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Heng-Cheng Chu
The incidence of Sjögren syndrome (SS) in primary biliary cirrhosis (PBC) patients is high. The influence of SS on the clinical outcomes of PBC patients, however, remains unclear. Our study retrospectively collected data on PBC-only patients and PBC patients with concomitant SS (PBC-SS) to compare the clinical differences of long-term outcomes between them.A total of 183 patients were diagnosed with PBC from January 1999 to December 2014 at our hospital. Of these, the authors excluded patients with diabetes, hypertension, advanced liver cirrhosis at initial diagnosis of PBC (Child-Turcotte-Pugh classification score of ≥7) and other liver diseases (ie, alcoholic liver disease, alpha-antitrypsin deficiency, viral hepatitis, and primary sclerosing cholangitis), and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26762471/chinese-sle-treatment-and-research-group-cstar-registry-vii-prevalence-and-clinical-significance-of-serositis-in-chinese-patients-with-systemic-lupus-erythematosus
#14
MULTICENTER STUDY
J Zhao, W Bai, P Zhu, X Zhang, S Liu, L Wu, L Ma, L Bi, X Zuo, L Sun, C Huang, X Tian, M Li, Y Zhao, X Zeng
OBJECTIVES: To investigate both the prevalence and clinical characteristics of serositis in Chinese patients with systemic lupus erythematosus (SLE) in a large cohort in the Chinese SLE Treatment and Research group (CSTAR) database. METHODS: A prospective cross-sectional study of patients with SLE was conducted based on the data from the CSTAR registry. Serositis was defined according to the 1999 revised American College of Rheumatology (ACR) criteria for SLE - that is, pleuritis/pleural effusion and/or pericarditis/pericardial effusion detected by echocardiography, chest X-ray or chest computerized tomography (CT) scan...
May 2016: Lupus
https://www.readbyqxmd.com/read/26668625/peritoneal-dialysis-treatment-for-severe-lupus-nephritis-patients-complicated-with-essential-organ-dysfunction
#15
Yan Zhou, Yusheng Yu, Zheng Tang, Shijun Li, Weixin Hu, Chunlei Luo, Zhihong Liu
The aim of the present study was to evaluate the clinical efficacy of peritoneal dialysis (PD) in patients with severe lupus nephritis (LN) complicated with organ dysfunction. In total, 13 severe LN patients complicated with multiple-organ dysfunction, who underwent PD treatment between November 2003 and September 2010, were enrolled in the study. Six patients received methylprednisolone pulse therapy due to lupus activity and progressive renal failure. These patients were complicated with severe edema, cardiac insufficiency and severe hypoalbuminemia...
December 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26657791/immunosuppressive-cd11b-ly6chi-monocytes-in-pristane-induced-lupus-mouse-model
#16
Huijuan Ma, Suigui Wan, Chang-Qing Xia
Myeloid-derived suppressor cells with immunosuppressive functions have been described to be associated with one of the mechanisms by which malignant tumors escape immune surveillance. However, little is known about the role of myeloid-derived suppressor cells in autoimmunity. In the current study, when we attempted to characterize the peritoneal cells in pristane-induced lupus model, as reported previously, we observed that there were markedly increased CD11b(+)Ly6C(hi) monocytes. Surprisingly, this type of monocytes was almost phenotypically identical to the reported monocytic myeloid-derived suppressor cells...
June 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/26613028/plasma-exchange-for-paediatric-kidney-disease-indications-and-outcomes-a-single-centre-experience
#17
Sudheer Kumar Reddy, Afsana Jahan, Swasti Chaturvedi, Indira Agarwal
BACKGROUND: Outcome data in paediatrics regarding the use of plasmapheresis for immunological kidney disease are scarce. OBJECTIVES: We aimed to evaluate the role of plasmapheresis in children presenting with severe renal impairment secondary to immunological kidney diseases. METHODS: A retrospective chart review of children admitted between January 2009 and August 2013 to the Paediatric Nephrology Unit, Christian Medical College, Vellore, India, and requiring plasma exchange was undertaken...
December 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26610594/differences-in-initial-treatment-modality-for-end-stage-renal-disease-among-glomerulonephritis-subtypes-in-the-usa
#18
MULTICENTER STUDY
Michelle M O'Shaughnessy, Maria E Montez-Rath, Richard A Lafayette, Wolfgang C Winkelmayer
BACKGROUND: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD), while peritoneal dialysis affords certain benefits over hemodialysis. Distributions and determinants of first ESRD treatment modality have not been compared across glomerulonephritis (GN) subtypes. METHODS: We identified all adult (18-75 years) patients with ESRD attributed to any of six GN subtypes [focal segmental glomerulosclerosis (FSGS), IgA nephropathy (IgAN), membranous nephropathy (MN), membranoproliferative GN (MPGN), lupus nephritis (LN) and vasculitis] who were first registered in the US Renal Data System (USRDS) between 1996 and 2011...
February 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26584539/citral-alleviates-an-accelerated-and-severe-lupus-nephritis-model-by-inhibiting-the-activation-signal-of-nlrp3-inflammasome-and-enhancing-nrf2-activation
#19
Shuk-Man Ka, Jung-Chen Lin, Tsai-Jung Lin, Feng-Cheng Liu, Louis Kuoping Chao, Chen-Lung Ho, Li-Tzu Yeh, Huey-Kang Sytwu, Kuo-Feng Hua, Ann Chen
INTRODUCTION: Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. NLRP3 inflammasome activation, reactive oxygen species (ROS) and mononuclear leukocyte infiltration in the kidney have been shown to provoke the acceleration and deterioration of LN, such as accelerated and severe LN (ASLN). Development of a novel therapeutic remedy based on these molecular events to prevent the progression of the disease is clinically warranted. METHODS: Citral (3,7-dimethyl-2,6-octadienal), a major active compound in a Chinese herbal medicine Litsea cubeba, was used to test its renoprotective effects in a lipopolysaccharide (LPS)-induced mouse ASLN model by examining NLRP3 inflammasome activation, ROS and COX-2 production as well as Nrf2 activation...
November 19, 2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26573552/eskd-transplantation-and-dialysis-in-lupus-nephritis
#20
REVIEW
Alberto J Sabucedo, Gabriel Contreras
Kidney disease resulting from systemic lupus erythematosus accounts for 1.9% of the end-stage kidney disease (ESKD) population in the United States. Systemic lupus erythematosus patients with lupus nephritis (LN) who progress to ESKD in the United States are mostly female (81%) and of African ancestry (49%), with a mean age of 41 years at initiation of renal replacement therapy (RRT). The incidence of ESKD in patients with LN steadily increased between 1982 and 1998 because RRT was offered more readily to LN patients in the United States...
September 2015: Seminars in Nephrology
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