Daniel Camprubí-Ferrer, Alexandru Tomazatos, Leire Balerdi-Sarasola, Ludovico G Cobuccio, Steven Van Den Broucke, Balázs Horváth, Marjan Van Esbroeck, Miguel J Martinez, Javier Gandasegui, Carme Subirà, Meritxell Saloni, Blaise Genton, Emmanuel Bottieau, Dániel Cadar, Jose Muñoz
BACKGROUND: Up to 45% of febrile returning travellers remain undiagnosed after a thorough diagnostic work-up, even at referral centers. Although metagenomic next-generation sequencing (mNGS) has emerged as a promising tool, evidence of its usefulness in imported fever is very limited. METHODS: Travellers returning with fever were prospectively recruited in three referral clinics from November 2017 to November 2019. Unbiased mNGS optimized for virus detection was performed on serum samples of participants with acute undifferentiated febrile illness (AUFI) and results were compared to those obtained by reference diagnostic methods (RDM)...
February 21, 2024: Journal of Travel Medicine