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Travel, malaria

Andrea K Boggild, Jennifer Geduld, Michael Libman, Cedric P Yansouni, Anne E McCarthy, Jan Hajek, Wayne Ghesquiere, Jean Vincelette, Susan Kuhn, David O Freedman, Kevin C Kain
BACKGROUND: Malaria remains the most common specific cause of fever in returned travellers and can be life-threatening. We examined demographic and travel correlates of malaria among Canadian travellers and immigrants to identify groups for targeted pretravel intervention. METHODS: Descriptive data on ill returned Canadian travellers and immigrants presenting to a CanTravNet site between 2004 and 2014 with a diagnosis of malaria were analyzed. Data were collected using the GeoSentinel data platform...
July 2016: CMAJ Open
Engin Burak Selcuk, Uner Kayabas, Hulisi Binbasioglu, Baris Otlu, Yasar Bayindir, Bulent Bozdogan, Mehmet Karatas
BACKGROUND: The number of international travellers is increasing worldwide. Although health risks related to international travel are important and generally well-understood, the perception of these risks was unclear among Turkish travellers. We aimed to evaluate the attitudes and health risk awareness of Turkish travellers travelling to African countries. METHOD: A survey was performed of Turkish travellers bound for Africa from Istanbul International Ataturk Airport in July 2013...
September 20, 2016: Travel Medicine and Infectious Disease
Josef Yayan, Kurt Rasche
Malaria is an acute, life-threatening infectious disease that spreads in tropical and subtropical regions. Malaria is mainly brought over to Germany by travelers, so the disease can be overlooked due to its nonspecific symptoms and a lack of experience of attending physicians. The aim of this study was to analyze, retrospectively, epidemiological and clinical data from patients examined for malaria. Patient data were collected from hospital charts at the Department of Internal Medicine, Saarland University Medical Center, Germany, for the period of 2004-2012...
September 20, 2016: Advances in Experimental Medicine and Biology
L Getaz, L Da Silva-Santos, H Wolff, M Vitoria, N Serre-Delcor, J C Lozano-Becerra, F Chappuis, P Albajar-Viñas
A number of infectious diseases amongst travelers and the immigrant populations are a major public health concern. Some have a long incubation period or remain asymptomatic or paucisymptomatic for many years before leading to significant clinical manifestations and/or complications. HIV, hepatitis B and C, tuberculosis or latent syphilis are among the most significant persistent diseases in migrants. Schistosomiasis and strongyloidiasis, for instance, are persistent helminthic infections that may cause significant morbidity, particularly in patients co-infected with HIV, hepatitis B and C...
October 2016: Revista Española de Sanidad Penitenciaria
Tamar Lachish, Maskit Bar-Meir, Neta Eisenberg, Eli Schwartz
BACKGROUND: Current guidelines recommend daily dosing of atovaquone-proguanil (AP), beginning a day before travel to endemic areas and continuing for 7 days after departure. Adherence of long-term travellers to daily malaria chemoprophylaxis tends to be poor, even when residing in highly endemic malaria regions. Evidence from a volunteer challenging study suggests that non-daily, longer intervals dosing of AP provides effective protection against Plasmodium falciparum This study examines the effectiveness of twice weekly AP prophylaxis in long-term travellers to highly endemic P...
June 2016: Journal of Travel Medicine
Michael Marks, Margaret Armstrong, Christopher J M Whitty, Justin F Doherty
BACKGROUND: Understanding geographic and temporal trends in imported infections is key to the management of unwell travellers. Many tropical infections can be managed as outpatients, with admission reserved for severe cases. METHODS: We prospectively recorded the diagnosis and travel history of patients admitted between 2000 and 2015. We describe the common tropical and non-tropical infectious diseases and how these varied based on region, reason for travel and over time...
August 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
Marlies E van Wolfswinkel, Liese C Koopmans, Dennis A Hesselink, Ewout J Hoorn, Rob Koelewijn, Jaap J van Hellemond, Perry J J van Genderen
BACKGROUND: Acute kidney injury (AKI) is a frequently encountered complication of imported Plasmodium falciparum infection. Markers of structural kidney damage have been found to detect AKI earlier than serum creatinine-based prediction models but have not yet been evaluated in imported malaria. This pilot study aims to explore the predictive performance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for AKI in travellers with imported P. falciparum infection...
2016: Malaria Journal
Michael R Hollingdale, Martha Sedegah, Keith Limbach
INTRODUCTION: Malaria remains a major threat to endemic populations and travelers, including military personnel to these areas. A malaria vaccine is feasible, as radiation attenuated sporozoites induce nearly 100% efficacy. AREAS COVERED: This review covers current malaria clinical trials using adenoviruses and pre-clinical research. Heterologous prime-boost regimens, including replication-deficient human adenovirus 5 (HuAd5) carrying malaria antigens, are efficacious...
September 8, 2016: Expert Review of Vaccines
Benjamin C Francis, Ximena Gonzalo, Sirisha Duggineni, Janice M Thomas, Caoimhe NicFhogartaigh, Zahir Osman Eltahir Babiker
BACKGROUND: Malaria is the most common imported tropical disease in the United Kingdom (UK). The overall mortality is low but inter-regional differences have been observed. METHODS: We conducted a 2-year retrospective review of clinical and laboratory records of patients with malaria attending three acute hospitals in East London from 1 April 2013 through 31 March 2015. Epidemiological and clinical characteristics of imported malaria were described and risk factors associated with severe falciparum malaria were explored...
June 2016: Journal of Travel Medicine
Zeynep Erdil, Celali Kurt, Hacer Özlem Kalaycı, Özgül Gözlükaya, Cemal Tayar
Malaria is a condition that threatens millions of people in many countries in spite of precautions. Sporadic cases have not been observed in our country since 2010, but imported malaria cases are still to be seen because of migration. In this study, two malaria cases are presented that appeared in a non-endemic region within 1 week. Complaints appeared 20 days later after leaving Ivory Coast in the first case and one week after returning from Ghana in the second case. With this two import cases which have a travel story about two different countries and non taking regular chemoprophylaxis; it is aimed to call attention that malaria is a question of common concern and a protozoon which needs to be struggled worldwide...
June 2016: Türkiye Parazitolojii Dergisi
Takeshi Tada, Akihiro Hitani, Natsue Hosono Honda, Shinichi Haruna, Tsuyoshi Yoshimura, Kosuke Haruki, Yasuhiro Tanaka
A 49-year-old healthy woman, who returned from Burkina Faso, visited an ear, nose, and throat clinic with complaints of left hearing loss, tinnitus, and dizziness. Pure tone audiometry demonstrated bilateral mild sensorineural hearing loss. Three days later, she was transported in an ambulance to a general hospital due to high fever and disturbance of consciousness. Plasmodium falciparum was found in the peripheral blood smear. After diagnosing severe falciparum malaria with cerebral involvement, quinine hydrochloride, clindamycin, and artemether/lumefantrine were administered...
August 28, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
A E Heywood, N Zwar, B L Forssman, H Seale, N Stephens, J Musto, C Lane, B Polkinghorne, M Sheikh, M Smith, H Worth, C R Macintyre
Immigrants and their children who return to their country of origin to visit friends and relatives (VFR) are at increased risk of acquiring infectious diseases compared to other travellers. VFR travel is an important disease control issue, as one quarter of Australia's population are foreign-born and one quarter of departing Australian international travellers are visiting friends and relatives. We conducted a 1-year prospective enhanced surveillance study in New South Wales and Victoria, Australia to determine the contribution of VFR travel to notifiable diseases associated with travel, including typhoid, paratyphoid, measles, hepatitis A, hepatitis E, malaria and chikungunya...
August 30, 2016: Epidemiology and Infection
Roos Visser, Quirijn de Mast, Imke Munnix, André van der Ven, Ton Dofferhoff
No abstract text is available yet for this article.
August 18, 2016: Travel Medicine and Infectious Disease
Karl-Heinz Herbinger, Ingrid Hanus, Mirjam Schunk, Marcus Beissner, Frank von Sonnenburg, Thomas Löscher, Gisela Bretzel, Michael Hoelscher, Hans Dieter Nothdurft, Kristina Lydia Huber
The present controlled cross-sectional study aimed to assess elevated values of C-reactive protein (CRP), a positive acute-phase protein, induced by imported infectious diseases (IDs) seen in patients consulting the University of Munich (1999-2015) after being in the tropics/subtropics. The analysis investigated data sets from 11,079 diseased German travelers (cases) returning from Latin America (1,986), Africa (3,387), and Asia (5,706), and from 714 healthy Germans who had not recently traveled (controls)...
October 5, 2016: American Journal of Tropical Medicine and Hygiene
Tobias Homan, Alexandra Hiscox, Collins K Mweresa, Daniel Masiga, Wolfgang R Mukabana, Prisca Oria, Nicolas Maire, Aurelio Di Pasquale, Mariabeth Silkey, Jane Alaii, Teun Bousema, Cees Leeuwis, Thomas A Smith, Willem Takken
BACKGROUND: Odour baits can attract host-seeking Anopheles mosquitoes indoors and outdoors. We assessed the effects of mass deployment of odour-baited traps on malaria transmission and disease burden. METHODS: We installed solar-powered odour-baited mosquito trapping systems (SMoTS) to households on Rusinga Island, Lake Victoria, western Kenya (mean population 24 879), in a stepped-wedge cluster-randomised trial. All residents in the completed health and demographic surveillance system were eligible to participate...
September 17, 2016: Lancet
David Bell, Alessandra E Fleurent, Michael C Hegg, John D Boomgard, Caitlin C McConnico
Despite advances in diagnostic technology, significant gaps remain in access to malaria diagnosis. Accurate diagnosis and misdiagnosis leads to unnecessary waste of resources, poor disease management, and contributes to a cycle of poverty in low-resourced communities. Despite much effort and investment, few new technologies have reached the field in the last 30 years aside from lateral flow assays. This suggests that much diagnostic development effort has been misdirected, and/or that there are fundamental blocks to introduction of new technologies...
2016: Malaria Journal
Iee Ho Choi, Pyoung Han Hwang, Sam Im Choi, Dae Yeol Lee, Min Sun Kim
Prompt malaria diagnosis is crucial so antimalarial drugs and supportive care can then be rapidly initiated. A 15-year-old boy who had traveled to Africa (South Africa, Kenya, and Nigeria between January 3 and 25, 2011) presented with fever persisting over 5 days, headache, diarrhea, and dysuria, approximately 17 days after his return from the journey. Urinalysis showed pyuria and hematuria. Blood examination showed hemolytic anemia, thrombocytopenia, disseminated intravascular coagulation, and hyperbilirubinemia...
September 2016: Journal of Korean Medical Science
John M Marshall, Adam Bennett, Samson S Kiware, Hugh J W Sturrock
The failure of the Global Malaria Eradication Program (GMEP) during the 1960s highlighted the relevance of human movement to both re-introducing parasites in elimination settings and spreading drug-resistant parasites widely. Today, given the sophisticated surveillance of human movement patterns and key traveler groups, it is hoped that interventions can be implemented to protect and treat travelers, prevent onward transmission in low transmission settings, and eliminate sources of transmission, including sources of drug-resistant parasites...
October 2016: Trends in Parasitology
Farah Jazuli, Terence Lynd, Jordan Mah, Michael Klowak, Dale Jechel, Stefanie Klowak, Howard Ovens, Sam Sabbah, Andrea K Boggild
BACKGROUND: Fever in the returned traveller is a potential medical emergency warranting prompt attention to exclude life-threatening illnesses. However, prolonged evaluation in the emergency department (ED) may not be required for all patients. As a quality improvement initiative, we implemented an algorithm for rapid assessment of febrile travelers (RAFT) in an ambulatory setting. METHODS: Criteria for RAFT referral include: presentation to the ED, reported fever and travel to the tropics or subtropics within the past year...
2016: BMJ Open
N Jaén-Sánchez, L Suárez-Hormiga, C Carranza-Rodríguez, M Hernández-Cabrera, E Pisos-Álamo, L García-Reina, J L Pérez-Arellano
OBJECTIVE: The objective of this paper was to determine the demographic characteristics and the evolution of international travelers treated at the Unit of Infectious and Tropical Medicine in order to improve precautions prior to travel and, thus reduce the occurrence of these diseases. METHODS: A retrospective study of all international travelers served in UEIMT (Las Palmas de Gran Canaria) during the period 1998-2013 was performed. The following variables were collected using a standardized protocol were analyzed: age, gender, date of consultation, type of traveler, countries of destination and preventive measures undertaken (malaria chemoprophylaxis and vaccines)...
October 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
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