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https://www.readbyqxmd.com/read/29452961/dipeptidyl-peptidase-4-inhibitors-dpp-4i-combined-with-vitamin-d3-an-exploration-to-treat-new-onset-type-1-diabetes-mellitus-and-latent-autoimmune-diabetes-in-adults-in-the-future
#1
Marcelo Maia Pinheiro, Felipe Moura Maia Pinheiro, Maria Luisa Trabachin
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic beta cells through cell injury caused primarily by cytotoxic T lymphocytes (CD8 + ). The pathophysiological basis of T1DM seems to be an imbalance between a reduced function of T regulatory lymphocytes and an increased inflammatory activity of Th17 lymphocytes caused by increased production of inflammatory cytokines, as IL-1β, IL-6, IL-17 and IFN-gamma due to environmental factors and genetic predisposition...
February 13, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29451877/influence-of-hyperbaric-oxygen-on-biomechanics-and-structural-bone-matrix-in-type-1-diabetes-mellitus-rats
#2
Pedro Henrique Justino Oliveira Limirio, Huberth Alexandre da Rocha Junior, Richarlisson Borges de Morais, Karen Renata Nakamura Hiraki, Ana Paula Coelho Balbi, Priscilla Barbosa Ferreira Soares, Paula Dechichi
BACKGROUND: The aim of this study was to evaluate the biomechanics and structural bone matrix in diabetic rats subjected to hyperbaric oxygen therapy (HBO). METHODS: Twenty-four male rats were divided into the following groups: Control; Control + HBO; Diabetic, and Diabetic + HBO. Diabetes was induced with streptozotocin (STZ) in the diabetic Groups. After 30 days, HBO was performed every 48h in HBO groups and all animals were euthanized 60 days after diabetic induction...
2018: PloS One
https://www.readbyqxmd.com/read/29433560/an-international-survey-on-hypoglycemia-among-insulin-treated-type-i-and-type-ii-diabetes-patients-turkey-cohort-of-the-non-interventional-io-hat-study
#3
Rıfat Emral, Tamer Tetiker, Ibrahim Sahin, Ramazan Sari, Ahmet Kaya, İlhan Yetkin, Sefika Uslu Cil, Neslihan Başcıl Tütüncü
BACKGROUND: Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from Turkey cohort are presented here. METHODS: A non-interventional study to determine the hypoglycemia incidence, retrospectively and prospectively, in Turkish T1DM and T2DM patients using a 2-part self-assessment questionnaire...
February 13, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29433332/generation-of-high-yield-insulin-producing-cells-from-human-induced-pluripotent-stem-cells-on-polyethersulfone-nanofibrous-scaffold
#4
Reyhaneh Nassiri Mansour, Ghasem Barati, Masoud Soleimani, Pegah Ghoraeian, Maryam Nouri Aleagha, Mousa Kehtari, Hossein Mahboudi, Fatemeh Hosseini, Hadi Hassannia, Mohammad Foad Abazari, Seyed Ehsan Enderami
Transplantation of islet is a promising method in treatment of patients with type 1 diabetes mellitus (T1DM), however, is limited by islet shortage. The aim of this study was to prepare a polyethersulfone (PES) nanofibrous scaffolds to evaluate the pancreatic differentiation of human induced pluripotent stem cells (hiPSCs). The differentiation process in tissue culture dishes and PES scaffolds was evaluated at mRNA and protein level by RT-qPCR and immunofluorescence assay, respectively. The functionality of differentiated cells was determined by insulin and C-peptide release in response to glucose challenges...
February 12, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29431304/ketoacidosis-in-newly-diagnosed-type-1-diabetes-in-children-and-adolescents-in-israel-prevalence-and-risk-factors
#5
Ori Eyal, Asaf Oren, Dganit Almasi-Wolker, Yardena Tenenbaum-Rakover, Marianna Rachmiel, Naomi Weintrob
BACKGROUND: Diabetic ketoacidosis (DKA) as the first presentation of type 1 diabetes mellitus (T1DM) is a serious complication that is preventable. OBJECTIVES: To identify risk factors for DKA at presentation of T1DM to delineate high-risk Israeli populations that could benefit from preventative measures. METHODS: Data for this multicenter retrospective study were collected from the medical files of three pediatric diabetes centers representing three districts in Israel...
February 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29422635/diabetes-quantifying-genetic-susceptibility-in-t1dm-implications-for-diagnosis-after-age-30
#6
Everett Meyer, David M Maahs
No abstract text is available yet for this article.
February 9, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29417618/evaluation-of-vitamin-d-receptor-gene-polymorphisms-fok-i-and-bsm-i-in-t1dm-saudi-children
#7
Rabab Ali, Iman Fawzy, Ihsan Mohsen, Ahmad Settin
BACKGROUND: Vitamin D deficiency conferred strongest susceptibility to pathogenesis of type 1 diabetes mellitus (T1DM). Altered gene expression and function have strong effect on VDR gene polymorphism. OBJECTIVES: We aimed to check for the association of two single nucleotide polymorphisms (SNPs) in VDR gene (Fok-I and Bsm-I) with T1DM in Saudi children. SUBJECTS AND METHODS: Cross-sectional study included 100 T1DM Saudi children, plus 102 unrelated healthy subjects...
February 8, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29416197/impact-of-insulin-delivery-method-on-hypoglycemia-incidence-in-pediatric-type-1-diabetes-mellitus-patients
#8
Snijezana Hasanbegovic, Emina Obarcanin, Edo Hasanbegovic, Nedim Begic
Introduction: Insulin therapy of pediatric patients with type 1 diabetes mellitus (T1DM) is highly demanding due to their dynamic growth, development and different daily life activities. Goal: To determine the optimal insulin delivery method for the prevention of hypoglycemia recorded by continuous monitoring of glucose in patients with insulin pump and PEN. Material and Methods: The study included patients up to 18 years of age with diagnosed T1DM and treated with insulin pump and by insulin therapy with PEN at the Pediatric Clinic of the Clinical Center in Sarajevo...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29412120/sodium-glucose-cotransporter-2-inhibitors-and-the-risk-of-diabetic-ketoacidosis-from-pathophysiology-to-clinical-practice
#9
Dimitrios Patoulias, Alexandros Manafis, Christos Mitas, Konstantinos Avranas, Georgios Lales, Ioanna Zografou, Christos Sambanis, Asterios Karagiannis
BACKGROUND: SGLT-2 inhibitors are a novel class of antidiabetic drugs, recently approved for the treatment of patients with T2DM. Their cardioprotective and renoprotective action, along with their beneficial effects on metabolic parameters, make them an attractive therapeutic option. Since 2015, when the US FDA issued warning regarding the increased risk of euDKA in the setting of SGLT-2 inhibitors administration, a vivid discussion upon the direct connection between this novel class and the major metabolic complication of diabetes mellitus is still ongoing...
February 6, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29411304/efficacy-of-anti-osteoporotic-medications-in-patients-with-type-1-and-2-diabetes-mellitus-a-systematic-review
#10
REVIEW
Panagiotis Anagnostis, Stavroula A Paschou, Nifon N Gkekas, Aikaterini-Maria Artzouchaltzi, Konstantinos Christou, Dimitrios Stogiannou, Andromachi Vryonidou, Michael Potoupnis, Dimitrios G Goulis
PURPOSE: Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with bone fragility and increased fracture risk. However, little is known regarding the effect of anti-osteoporotic treatment on bone mineral density (BMD) and/or fracture risk in these patients. We aimed to systematically investigate the efficacy of anti-osteoporotic medications in patients with diabetes in comparison with non-diabetic subjects. METHODS: MEDLINE and Scopus databases were searched (up to 31st October 2017)...
February 6, 2018: Endocrine
https://www.readbyqxmd.com/read/29410325/effects-of-co-existing-autoimmune-diseases-on-serum-lipids-and-lipoprotein-subclasses-profile-in-paediatric-patients-with-type-1-diabetes-mellitus
#11
Dragana Bojanin, Tatjana Milenkovic, Jelena Vekic, Rade Vukovic, Aleksandra Zeljkovic, Jelena Janac, Jasmina Ivanisevic, Sladjana Todorovic, Ilijana Mazibrada, Vesna Spasojevic-Kalimanovska
OBJECTIVE: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. DESIGN AND METHODS: Study included 201 subjects with T1DM (14.1 ± 2.9 years) and 141 age- and gender-matched controls...
February 1, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29410149/cost-calculation-for-a-flash-glucose-monitoring-system-for-uk-adults-with-type-1-diabetes-mellitus-receiving-intensive-insulin-treatment
#12
Richard Hellmund, Raimund Weitgasser, Deirdre Blissett
AIMS: To estimate the costs associated with a flash glucose monitoring system as a replacement for routine self-monitoring of blood glucose (SMBG) in patients with type 1 diabetes mellitus (T1DM) using intensive insulin, from a UK National Health Service (NHS) perspective. METHODS: The base-case cost calculation was created using the maximum frequency of glucose monitoring recommended by the 2015 National Institute for Health and Care Excellence guidelines (4-10 tests per day)...
February 1, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29408994/impact-of-c-peptide-status-on-the-response-of-glucagon-and-endogenous-glucose-production-to-induced-hypoglycaemia-in-t1d
#13
Sabine Zenz, Julia K Mader, Werner Regittnig, Martina Brunner, Stefan Korsatko, Beate Boulgaropoulos, Christoph Magnes, Reingard Raml, Sophie H Narath, Philipp Eller, Thomas Augustin, Thomas R Pieber
Context: Complete loss of beta-cell function in type 1 diabetes (T1DM) patients may lead to an increased risk of severe hypoglycaemia. Objective: We aimed to determine the impact of C-peptide status on glucagon response and endogenous glucose production (EGP) during hypoglycaemia in T1DM patients. Design/ Setting: We conducted an open, comparative trial. Patients: 10 C-peptide positive (C-pos) and 11 matched C-peptide negative (C-neg) T1DM patients were enrolled...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29408092/topical-application-of-hydroxysafflor-yellow-a-accelerates-the-wound-healing-in-streptozotocin-induced-t1dm-rats
#14
Si-Qian Gao, Chen Chang, Xiao-Qian Niu, Long-Jian Li, Yan Zhang, Jian-Qing Gao
To investigate the effects of Hydroxysafflor Yellow A (HSYA), which is derived from safflower, on the proliferation, migration and angiogenesis of cells in vitro and its potential efficacy in vivo when topically applied to a diabetic wound. Human umbilical vein endothelial cells (HUVECs) and mouse macrophage cells (RAW264.7) were used to evaluate angiogenesis and anti-inflammatory activities, respectively. The influence of HSYA on the wound scratch assay was investigated in keratinocytes. A splinted excisional wound model in rats with TIDM induced by streptozotocin was used to assess the effects of wound healing...
January 31, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29392186/environmental-toxicant-exposures-and-type-2-diabetes-mellitus-two-interrelated-public-health-problems-on-the-rise
#15
Marcelo G Bonini, Robert M Sargis
Rates of type 2 diabetes mellitus (T2DM) are rising rapidly across the globe and the impact of this devastating disease threatens to plague the 21st century. While some contributing factors are well-recognized (e.g. sedentary lifestyles and caloric excess), others diabetes-promoting risk factors are less established or poorly appreciated. The latter category includes environmental exposures to diabetogenic contaminants. Herein we review some of the latest concepts and mechanisms by which environmental exposures may contribute to rising rates of T2DM with a particular focus on mechanisms involving mitochondrial dysfunction and imbalances in reactive oxygen species (ROS)...
February 2018: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/29391429/non-invasive-detection-of-divergent-metabolic-signals-in-insulin-deficiency-vs-insulin-resistance-in%C3%A2-vivo
#16
Cornelius von Morze, Prasanna K R Allu, Gene Y Chang, Irene Marco-Rius, Eugene Milshteyn, Zhen J Wang, Michael A Ohliger, Catherine E Gleason, John Kurhanewicz, Daniel B Vigneron, David Pearce
The type 2 diabetic phenotype results from mixed effects of insulin deficiency and insulin resistance, but the relative contributions of these two distinct factors remain poorly characterized, as do the respective roles of the gluconeogenic organs. The purpose of this study was to investigate localized in vivo metabolic changes in liver and kidneys of contrasting models of diabetes mellitus (DM): streptozotocin (STZ)-treated wild-type Zucker rats (T1DM) and Zucker diabetic fatty (ZDF) rats (T2DM). Intermediary metabolism was probed using hyperpolarized (HP) [1-13C]pyruvate MRI of the liver and kidneys...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29391240/atorvastatin-and-insulin-equally-mitigate-brain-pathology-in-diabetic-rats
#17
Wasana Pratchayasakul, La-Ongdao Thongnak, Kenneth Chattipakorn, Anusorn Lungaphin, Anchalee Pongchaidecha, Pattarapong Satjaritanun, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn C Chattipakorn
Although insulin and atorvastatin have been shown to exert glycemic control and could improve brain function, the effects of atorvastatin or insulin as well as the combination of atorvastatin plus insulin on brain pathology in diabetes mellitus type 1 (T1DM) are unclear. Therefore, this study investigated the effect of atorvastatin, insulin or combined drugs on brain pathology in streptozotocin-induced diabetic rats. Thirty-six male rats were divided into two groups, a control group (n = 12) and a diabetic or experimental group (n = 24)...
January 29, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29389505/well-being-diabetes-management-and-breastfeeding-in-mothers-with-type-1-diabetes-an-explorative-analysis
#18
Karolina Linden, Marie Berg, Annsofie Adolfsson, Carina Sparud-Lundin
OBJECTIVES: The aim was to explore and investigate associations between well-being, diabetes management and breastfeeding in mothers with type 1 diabetes mellitus (T1DM) up to six months postpartum. METHODS: An explorative analysis of self-reported questionnaires measuring general well-being, sense of coherence, self-efficacy of diabetes management and experiences of diabetes management during breastfeeding, which were distributed to 155 mothers with T1DM at two months and at six months after childbirth...
March 2018: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/29389159/the-role-of-parent-and-child-self-regulation-in-children-s-glycemic-control
#19
Dione Healey, Andrew R Gray, Matthew Chae, Barry J Taylor, Julie Lawrence, David M Reith, Benjamin J Wheeler
OBJECTIVE: Type 1 diabetes mellitus (T1DM) is a lifelong, metabolic disorder, typically arising in childhood and adolescence. Despite recent advances in diabetes management techniques, glycemic control remains substandard for many individuals This study examined the role of parental and child self-regulation in predicting effective glycemic control in children and adolescents with Type 1 diabetes mellitus (T1DM). METHOD: Sixty-three families (with children aged 3-18 years) with T1DM participated...
February 1, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29386248/trends-in-hospital-admission-for-diabetic-ketoacidosis-in-adults-with-type-1-and-type-2-diabetes-in-england-1998-2013-a-retrospective-cohort-study
#20
Victor W Zhong, Juhaeri Juhaeri, Elizabeth J Mayer-Davis
OBJECTIVE: This study determined trends in hospital admission for diabetic ketoacidosis (DKA) in adults with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) from 1998 to 2013 in England. RESEARCH DESIGN AND METHODS: The study population included 23,246 adults with T1DM and 241,441 adults with T2DM from the Clinical Practice Research Datalink and Hospital Episode Statistics. All hospital admissions for DKA as the primary diagnosis from 1998 to 2013 were identified...
January 31, 2018: Diabetes Care
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