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https://www.readbyqxmd.com/read/29221142/d-4f-increases-microrna-124a-and-reduces-neuroinflammation-in-diabetic-stroke-rats
#1
Ruizhuo Ning, Poornima Venkat, Michael Chopp, Alex Zacharek, Tao Yan, Xu Cui, Don Seyfried, Jieli Chen
D-4F is an apolipoprotein-A1 mimetic peptide that promotes anti-inflammatory effects. MicroRNA-124 is the most abundant brain-specific microRNA and has anti-inflammatory effects. In this study, we investigated the therapeutic efficacy and mechanisms of D-4F treatment of stroke in type one diabetes mellitus (T1DM) rats. Male Wistar rats were induced with T1DM, subjected to embolic middle cerebral artery occlusion and treated with PBS or D-4F (1 mg/kg i.p.) at 2, 24 and 48 hours after stroke (n=8/group). A battery of function tests, brain blood barrier (BBB) integrity, white matter changes and microRNA expression were evaluated in vivo and in vitro...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218780/under-treatment-of-hypertension-and-hypercholesterolemia-in-children-and-adolescents-with-type-1-diabetes-long-term-follow-up-on-time-trends-in-the-occurrence-of-cardiovascular-disease-risk-factors-and-medications-use
#2
Fariba Ahmadizar, Patrick Souverein, Anthonius de Boer, Anke H Maitland-van der Zee
AIMS: 1) To evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and occurrence of CVD events in children with type 1 diabetes mellitus (T1DM), and 2) To assess determinants of under-treatment of CVD risk factors. METHODS: A retrospective cohort study was conducted in 3,728 children (<19 years) with T1DM and up to 5 age and gender-matched diabetes-free children (reference cohort) (n=18,513) using data from the Clinical Practice Research Datalink (CPRD)...
December 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29218110/downregulation-of-cathepsin-g-reduces-the-activation-of-cd4-t-cells-in-murine-autoimmune-diabetes
#3
Fang Zou, Xiaoyang Lai, Jing Li, Shuihong Lei, Lei Hu
Type 1 diabetes mellitus (T1DM) is an autoimmune disease due to progressive injury of islet cells mediated by T lymphocytes (T cells). Our previous studies have shown that only cathepsin G (CatG), not other proteases, is involved in the antigen presentation of proinsulin, and if the presentation is inhibited, the activation of CD4+ T cells induced by proinsulin is alleviated in T1DM patients, and CatG-specific inhibitor reduces the activation of CD4+ cells induced by proinsulin in T1DM patients. Therefore, we hypothesize that CatG may play an important role in the activation of CD4+ T cells in T1DM...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29215678/decrease-in-mandibular-cortical-in-patients-with-type-1-diabetes-mellitus-combined-with-poor-glycemic-control
#4
Francisco Ivison Rodrigues Limeira, Patrícia Ravena Meneses Rebouças, Denise Nóbrega Diniz, Daniela Pita de Melo, Patrícia Meira Bento
In this study we analyzed the mandibular cortical bone of patients with type 1 diabetes mellitus (T1DM) and non-diabetic. Fifty patients with T1DM and 100 non-diabetic ones paired by age and gender were analyzed. Two double-blinded observers evaluated 150 digital panoramic images of both groups. The mandibular cortical bone was analyzed using the Mandibular Cortical Index (MCI), Mental Index (MI), Gonial Index (GI), Antegonial Index (AI) and Upper and Lower Panoramic Mandibular Indexes (UPMI and LPMI), with the aid of RADIOIMP® software...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29214182/thyroid-dysfunction-among-greek-patients-with-type-1-and-type-2-diabetes-mellitus-as-a-disregarded-comorbidity
#5
Maria E Barmpari, Maria Kokkorou, Anastasia Micheli, Irene Alexiou, Elefteria Spanou, Marina Noutsou, Anastasia Thanopoulou
Introduction: The aim of this study was to determine the prevalence of thyroid dysfunction in Greek patients with type 1 (T1DM) and type 2 (T2DM) diabetes mellitus as well as its possible relations to glycaemic control and to diabetic complications. Methods: A total of 1015 patients, consecutively followed in the Outpatient Diabetes Center, were studied. Anthropometric and biochemical measurements, occurrence of diabetes complications, and classical comorbidities were assessed...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29213156/gastroesophageal-reflux-disease-in-patients-with-long-standing-type-1-diabetes-mellitus-utility-of-two-self-report-questionnaires-in-a-multifactorial-disease
#6
Emmanuel Marin Valdez-Solis, Claudia Ramírez-Rentería, Aldo Ferreira-Hermosillo, Mario Molina-Ayala, Victoria Mendoza-Zubieta, Víctor Rodríguez-Pérez
Background: Gastroesophageal pathologies are common and multifactorial in patients with type 1 diabetes (T1DM). The evaluation with endoscopy and 24 h pH esophageal monitoring is expensive and not always available in all medical centers, especially in developing countries so more cost-effective algorithms for diagnosis are required. Clinical questionnaires are easy to apply but its utility for gastroesophageal reflux disease screening in patients with long standing T1DM must be analyzed...
September 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29207798/does-vitamin-d-supplementation-improve-glycaemic-control-in-children-with-type-1-diabetes-mellitus-a-randomized-controlled-trial
#7
Shreya Sharma, Niranjan Biswal, Adhisivam Bethou, Medha Rajappa, Sadish Kumar, Vickneshwaran Vinayagam
Introduction: Vitamin D endocrine system is a potential immune system modulator and has been implicated in the pathogenesis of several autoimmune diseases including Type 1 Diabetes Mellitus (T1DM). Studies have demonstrated an inverse risk relationship between T1DM and Vitamin D levels and also, shown a reduced risk of the disease with its supplementation. Aim: To evaluate the role of Vitamin D as an adjuvant in improving glycaemic control and residual pancreatic beta-cell function...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207795/association-between-vascular-endothelial-markers-and-carotid-intima-media-thickness-in-children-and-adolescents-with-type-1-diabetes-mellitus
#8
Noushin Rostampour, Kiavash Fekri, Elham Hashemi-Dehkordi, Mahdieh Obodiat
Introduction: Type 1 Diabetes Mellitus (T1DM) is one of the important risk factor for cardiovascular disease. Endothelial dysfunction and increased Carotid Intima-Media Thickness (CIMT) result in cardiovascular complications. Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion Molecule-1 (ICAM-1) are two adhesion molecules that are markers of early atherosclerosis and play a significant role in developing atherosclerosis. Aim: To evaluate CIMT and its association with the levels of ICAM-1 and VCAM-1 in children and adolescents with T1DM...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204256/reproductive-disturbances-among-saudi-adolescent-girls-and-young-women-with-type-1-diabetes-mellitus
#9
Rim Braham, Asirvatham Alwin Robert, Maha Ali Musallam, Abdulaziz Alanazi, Nawaf Bin Swedan, Mohamed Abdulaziz Al Dawish
AIM: To identify reproductive disturbances among adolescent girls and young women with type 1 diabetes mellitus (T1DM) in Saudi Arabia. METHODS: This cross sectional study was conducted among 102 female with T1DM, (aged 13-29 years) who attended the Diabetes Clinic at Diabetes Treatment Center, Prince Sultan Military Medical City, Saudi Arabia between April 2015 to March 2016. Clinical history, anthropometric characteristics and reproductive disturbance were collected through a questionnaire...
November 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/29202762/myocyte-membrane-and-microdomain-modifications-in-diabetes-determinants-of-ischemic-tolerance-and-cardioprotection
#10
REVIEW
Jake Russell, Eugene F Du Toit, Jason N Peart, Hemal H Patel, John P Headrick
Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a 'wicked triumvirate': (i) increasing the risk and incidence of IHD and myocardial ischemia; (ii) decreasing myocardial tolerance to ischemia-reperfusion (I-R) injury; and (iii) inhibiting or eliminating responses to cardioprotective stimuli. Changes in ischemic tolerance and cardioprotective signaling may contribute to substantially higher mortality and morbidity following ischemic insult in DM patients...
December 4, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29192247/immunotherapy-pdl1-restoration-reverses-t1dm
#11
Conor A Bradley
No abstract text is available yet for this article.
December 1, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29191919/on-type-1-diabetes-mellitus-pathogenesis
#12
Stavroula A Paschou, Nektaria Papadopoulou-Marketou, George Chrousos, Christina Kanaka-Gantenbein
Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the endocrine pancreas. Pathogenesis of type 1 diabetes mellitus is different from that of type 2 diabetes mellitus, where both insulin resistance and reduced secretion of insulin by the β cells play a synergistic role. We will present genetic, environmental and immunologic factors that destroy β cells of the endocrine pancreas and lead to insulin deficiency. The process of autoimmune destruction takes place in genetically susceptible individuals under the triggering effect of one or more environmental factors and usually progresses over a period of many months to years, during which period patients are asymptomatic and euglycemic, but positive for relevant autoantibodies...
November 30, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29190990/smoking-and-the-risk-of-diabetic-nephropathy-in-patients-with-type-1-and-type-2-diabetes-a-meta-analysis-of-observational-studies
#13
Ning Jiang, Feng Huang, Xiurong Zhang
Background: Conflicting evidence exists for observational studies on whether tobacco smoking is a risk factor for diabetic nephropathy (DN) in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM). In this meta-analysis, we aimed to assess the effects of tobacco smoking on the development of DN. Materials and Methods: We searched MEDLINE and EMBASE databases from their inception to March 31st, 2017 for cross-sectional, case-control, and prospective cohort studies...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29187651/-comparison-of-effects-between-il-2-and-il-7-on-glutamic-acid-decarboxylase-65-reactive-t-cell-responses-in-patients-with-type-1-diabetes
#14
Jiao Yuan, Qiuyan Cui, Wei Tang, Chen Chao, Zhiguang Zhou, Lin Yang
To explore the type of cytokine (IL-2 or IL-7) and its most optimal concentration regarding the improvement of the signal-to-noise ratio of glutamic acid decarboxylase 65 (GAD65) in enzyme-linked immunospot (ELISPOT) assay in Type 1 diabetic (T1DM) patients.
 Methods: Twenty T1DM patients (Group A) and sixteen healthy controls matched with age and sex (Group B) were enrolled in our study, and their peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll method. GAD65, internal control and Pediacel served as "five-for-one" vaccine were selected as the stimulating antigen...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29178923/guided-self-determination-young-versus-standard-care-in-the-treatment-of-young-females-with-type-1-diabetes-study-protocol-for-a-multicentre-randomized-controlled-trial
#15
Josephine Haas, Martina Persson, Anna Lena Brorsson, Eva Hagström Toft, Anna Lindholm Olinder
BACKGROUND: Female adolescents with type 1 diabetes mellitus (T1DM) have the most unsatisfactory glycaemic control of all age groups and report higher disease burden, poorer perceived health, and lower quality of life than their male counterparts. Females with T1DM face an excess risk of all-cause mortality compared with men with T1DM. New methods are needed to help and support young females with T1DM to manage their disease. A prerequisite for successful diabetes management is to offer individualized, person-centred care and support the patient's own motivation...
November 24, 2017: Trials
https://www.readbyqxmd.com/read/29175120/urinary-mirna-377-and-mirna-216a-as-biomarkers-of-nephropathy-and-subclinical-atherosclerotic-risk-in-pediatric-patients-with-type-1-diabetes
#16
Mona Hussein El-Samahy, A A Adly, Yasmine Ibrahim Elhenawy, E A Ismail, Shaimaa Abdelmalik Pessar, Mohamed El-Sayed Mowafy, Mohammed Salah Saad, Hossam Hassan Mohammed
BACKGROUND: Urinary microRNAs (miRNAs) play a role in the pathogenesis of chronic kidney disease (CKD). AIM: To identify the expression of urinary miR-377 and miR-216a in 50 children and adolescents with type 1 diabetes (T1DM) compared with 50 healthy controls and assess their relation to the degree of albuminuria, glycemic control and carotid intimal thickness (CIMT) as an index of atherosclerosis. METHODS: Diabetic subjects were divided into normoalbuminuric and microalbuminuric groups according to urinary albumin creatinine ration (UACR)...
November 7, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29171466/-the-attitude-of-patients-with-types-1-and-2-diabetes-mellitus-towards-having-the-disease
#17
I E Sapozhnikova, E N Zotina
AIM: To analyze the types of attitude towards disease, their relationships to its course in patients with diabetes mellitus (DM). SUBJECTS AND METHODS: 418 patients with DM, including 318 with type 2 DM (T2DM) and 100 with Type 1 (T1DM), were examined. Clinical and laboratory examinations were performed; the types of attitude towards the disease were studied. RESULTS: The patients with T2DM were more frequently found to have anxious (12.9%) and hypochondriacal (10...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29171465/-a-20-year-prospective-follow-up-study-to-evaluate-the-development-of-retinopathy-and-nephropathy-after-the-onset-of-type-1-diabetes-mellitus-contribution-of-glycemic-control-and-metabolic-memory
#18
L L Bolotskaya, E G Bessmertnaya, M V Shestakova, M Sh Shamkhalova, L V Nikankina, A V Ilyin, I S Glek, A V Zolotukhin, I I Dedov
AIM: To assess the time course of changes in the level of glycated hemoglobin (HbA1c) for 20 years after the onset of type 1 diabetes mellitus (T1DM) and to compare its correlation with the development of microvascular complications, such as diabetic retinopathy (DR) and diabetic nephropathy (DN). SUBJECTS AND METHODS: A total of 187 children with new-onset T1DM were registered in Moscow in 1994. During the 20-year follow-up study, these patients underwent regular check-ups at the Endocrinology Research Center, Ministry of Health of the Russian Federation, which included assessment of physical data, HbA1c 2-4 times a year, biochemical blood and albuminuria tests (once per year), and ophthalmologic examination (twice a year)...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29163733/can-antioxidative-status-be-involved-in-type-1-diabetes
#19
Cintia Castro-Correia, M Luz Maia, Sonia Norberto, Cristina Costa-Santos, M Fatima Barroso, Ana Carvalho, Manuel Fontoura, Valentina Domingues, Conceicao Calhau
Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disease with beta-cell destruction, resulting in insulin deficiency. It is now clear that environmental factors also play a role in disease development. The prevalence of type 1 diabetes in children and young people in Portugal is 0.16% between 0 and 19 years of age. The main cause of death in T1DM is cardiovascular disease, and early endothelial dysfunction is its pathophysiologycal precursor. Hyperglycemia is associated with increased production of free radicals and increased oxidative stress...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29162560/diabetes-data-management-system-to-improve-glycemic-control-in-people-with-type-1-diabetes-prospective-cohort-study
#20
Concetta Irace, Matthias Axel Schweitzer, Cesare Tripolino, Faustina Barbara Scavelli, Agostino Gnasso
BACKGROUND: Smartphone and Web technology can improve the health care process, especially in chronic diseases. OBJECTIVE: The aim of this study was to investigate whether the use of blood glucose (BG) data management system, which enables connection to smartphones, the Web, the cloud, and downloading, can improve glycemic control in subjects with type 1 diabetes mellitus (T1DM). METHODS: This study was a prospective, single-arm, cohort feasibility study with 6 months of duration...
November 21, 2017: JMIR MHealth and UHealth
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