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https://www.readbyqxmd.com/read/28098594/mediators-of-diabetic-neuropathy-is-hyperglycemia-the-only-culprit
#1
Anna Grisold, Brian C Callaghan, Eva L Feldman
PURPOSE OF REVIEW: Diabetic peripheral neuropathy (DPN) is a disabling, highly prevalent complication of both type 1 and type 2 diabetes mellitus (T1DM and T2DM). Large clinical studies support the concept that, in addition to hyperglycemia, components of the metabolic syndrome (MetS) may underlie the pathogenesis of DPN, especially in T2DM. This review will present the evidence supporting the MetS and its individual components as potential causal factors for the development of neuropathy...
January 16, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28093842/gilbert-syndrome-in-patients-with-type-1-diabetes-prevalence-glycemic-control-and-microalbuminuria
#2
Sigal Singer, Nurit Pilpel, Orit Pinhas-Hamiel
BACKGROUND: Gilbert syndrome (GS) is a common hereditary condition, characterized by intermittent unconjugated hyperbilirubinemia. In adults with type 2 diabetes and GS, a markedly lower prevalence of nephropathy was documented, suggesting a beneficial effect of hyperbilirubinemia. We investigated the prevalence of GS among individuals with type 1 diabetes mellitus (T1DM), and the prevalence of microalbuminuria. METHODS: The prevalence of GS was assessed in 401 (204 female) patients with T1DM, median age 21...
January 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28089343/assessment-of-microvascular-endothelial-function-in-type-1-diabetes-using-laser-speckle-contrast-imaging
#3
Alessandra S de M Matheus, Eliete Leão Silva Clemente, Maria de Lourdes Guimarães Rodrigues, Débora Cristina Torres Valença, Marília B Gomes
OBJECTIVE: To test whether laser speckle contrast imaging (LSCI) coupled with physiological post-occlusive reactive hyperemia (PORH) and pharmacological iontophoresis of acetylcholine (ACh) as local vasodilator stimuli could distinguish between cutaneous microvascular responses of Type 1 Diabetes (T1DM)'s patients with endothelial dysfunction and that of healthy controls. METHODS: Patients with T1DM aged ≥12years completed a clinical-epidemiological questionnaire...
January 3, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28086765/health-related-quality-of-life-hrqol-and-its-associated-factors-in-children-with-type-1-diabetes-mellitus-t1dm
#4
Marta Murillo, Joan Bel, Jacobo Pérez, Raquel Corripio, Gemma Carreras, Xavier Herrero, Josep-Maria Mengibar, Dolors Rodriguez-Arjona, Ulrike Ravens-Sieberer, Hein Raat, Luis Rajmil
BACKGROUND: The objective of the study was to describe the baseline health-related quality of life (HRQOL) in a cohort of children and adolescents with type 1 diabetes mellitus (T1DM), and analyze its associated clinical and sociodemographic factors, assessing HRQOL through internet. METHODS: This was a descriptive study of 136 patients with T1DM from 5 hospitals in Catalonia, Spain (72 girls, mean age 13.4 years (range 8-19). Inclusion criteria were more than 6 months from diagnosis, more than 8 years old and without cognitive problems...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28067892/impact-of-type-1-diabetes-mellitus-and-celiac-disease-on-nutrition-and-quality-of-life
#5
J G Nunes-Silva, V S Nunes, R P Schwartz, S Mlss Trecco, D Evazian, M L Correa-Giannella, M Nery, M S Queiroz
OBJECTIVE: Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are autoimmune diseases and have similar genetic patterns. T1DM treatment is based on diet, physical activity and insulin therapy, whereas CD depends on dietary changes with restriction of wheat, rye and barley. The aim of the study was to evaluate the quality of life (QoL) of individuals with the association of T1DM and CD, to characterize their nutritional status and to compare it with those with only one disease and healthier controls...
January 9, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28057322/the-assessment-of-fetal-brain-growth-in-diabetic-pregnancy-using-in-utero-magnetic-resonance-imaging
#6
M Paddock, R Akram, D A Jarvis, P Armitage, S Song, P Madhuvrata, P D Griffiths
AIM: To assess fetal brain growth over the third trimester in pregnant women with diabetes using in utero magnetic resonance imaging (iuMRI) to determine if greater brain growth occurs in type 1 (T1DM) when compared to gestational (GDM) diabetes mellitus. MATERIALS AND METHODS: Each consented participant was scanned at three fixed times during the third trimester using iuMRI. One hundred and fifty-seven patients were approached, 48 participants were recruited, and 36 complete data sets were analysed...
January 3, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28053930/effect-of-socioeconomic-factors-and-family-history-on-the-incidence-of-diabetes-in-an-adult-diabetic-population-from-algeria
#7
Nour El Houda Ferdi, Khalida Abla, Haroun Chenchouni
BACKGROUND: Diabetes mellitus is a serious public health problem worldwide and particularly in developing countries. In Algeria, this metabolic disorder occurs with a wide variety or atypical forms that linked to multiple risk factors including local habits and traditions. This study aimed to determine the impact of risk factors (metabolic syndrome, social, cultural, physical activity, family history and the treatment used) on the incidence of diabetes. METHODS: This cross-sectional study was conducted in 2013 on a random sample from a resident population in Tebessa, Northeast Algeria, which underwent a significant expanding of diabetes prevalence conditioned by profound socioeconomic changes...
December 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28052873/path-of-translational-discovery-of-urological-complications-of-obesity-and-diabetes-ucod
#8
Firouz Daneshgari, Guiming Liu, Ann T Hanna-Mitchell
Diabetes Mellitus (DM) is a prevalent chronic disease. Type 1 diabetes mellitus (T1DM) is a metabolic disorder that is characterized by hyperglycemia in the context of absolute lack of insulin; whereas type 2 diabetes mellitus (T2DM) is due to insulin resistance-related relative insulin deficiency. Obesity is an established risk factor for T2DM. In comparison with T1DM, T2DM is more complex. The natural history of T2DM in most patients typically involves a course of obesity to impaired glucose tolerance, to insulin resistance and hyperglycemia...
January 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28049242/factors-associated-with-the-presence-and-severity-of-diabetic-ketoacidosis-at-diagnosis-of-type-1-diabetes-in-korean-children-and-adolescents
#9
Hye Jin Lee, Hyeoh Won Yu, Hae Woon Jung, Young Ah Lee, Jae Hyun Kim, Hye Rim Chung, Jaeho Yoo, Eunyoung Kim, Jeesuk Yu, Choong Ho Shin, Sei Won Yang, Seong Yong Lee
The aim of this study was to identify the risk factors for presence and severity of diabetic ketoacidosis (DKA) at the onset of type 1 diabetes mellitus (T1DM) in Korean children and adolescents. A retrospective chart review of children and adolescents newly diagnosed with T1DM was conducted in seven secondary and tertiary centers in Korea. Eligible subjects were < 20 years of age and had records on the presence or absence of DKA at the time of T1DM diagnosis. DKA severity was categorized as mild, moderate, or severe...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28033258/impact-of-disease-management-programs-on-metabolic-control-in-patients-with-type-1-diabetes-mellitus-a-cohort-study-in-shantou-china
#10
Kun Lin, Xiaoping Yang, Yixi Wu, Shuru Chen, Guoshu Yin, Jianjun Zhan, Chujia Lin, Wencan Xu, Yongsong Chen, Dan Lin, Peiwen Xie, Yishan Fang, Qiuqiang Lin, Shaoda Lin
The aim of this study is to evaluate the effect of diabetes disease management program (DMP) on glycemic control in type 1 diabetes mellitus (T1DM) patients in Shantou China.A sample of 240 participants recruited from 3C study Shantou subgroup was followed up in DMP for 3 years. The DMP provided self-management education, individualized therapy plan, diabetes complications screening, and laboratory examination periodical according to clinical practice guidelines. Primary outcomes were changes in hemoglobin A1C (HbA1c)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28031093/clinical-characteristics-of-261-cases-of-hospitalized-patients-with-type-1-diabetes-mellitus
#11
Jing Yang, Mei-Cen Zhou, Kai Feng, Ou Wang, Hua-Bing Zhang, Wei Li, Fan Ping, Jing Yang, Yu-Xiu Li
Objective To retrospectively analyze the clinical characteristics of 261 cases of hospitalized patients with type 1 diabetes mellitus (T1DM) in Peking Union Medical College Hospital (PUMCH).Methods Clinical data of 261 cases of hospitalized patients diagnosed with T1DM in the Department of Endocrinology at PUMCH from January 2007 to December 2014 were analyzed retrospectively. All patients were divided into the T1DM antibodies positive group (n=180) and negative group (n=81) according to the results of immunohistochemistry, in which 123 newly diagnosed T1DM patients were divided into the adult onset group (>18 years, n=58) and non-adult onset group (≤18 years, n=65) according to the onset age of T1DM, respectively...
June 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28018288/vitamin-d-on-early-stages-of-diabetic-kidney-disease-a-cross-sectional-study-in-patients-with-type-1-diabetes-mellitus
#12
João Soares Felício, Rafael Mendonça Luz, Franciane Trindade Cunha de Melo, Fabricio de Souza Resende, Alana Ferreira de Oliveira, Amanda Soares Peixoto, João Felício Abrahão Neto, Carolina Tavares Carvalho, Denisson Dias da Silva, Marcia Costa Dos Santos, Natércia Neves Marques de Queiroz, Manuela Nascimento de Lemos, Elizabeth Sumi Yamada, Karem Miléo Felício
CONTEXT: Genetic and environmental factors are involved in the pathogenesis of type 1 diabetes mellitus (T1DM), and vitamin D (VD) deficiency appears as a candidate to risk factor for developing diabetic kidney disease (DKD). OBJECTIVE: The purpose of study was to evaluate the existence of an association between low levels of VD and the presence and degree of DKD in T1DM. PATIENTS AND METHODS: We performed a cross-sectional study, between November 2014 and December 2015...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28017523/healthcare-resource-use-direct-and-indirect-costs-of-hypoglycemia-in-type-1-and-type-2-diabetes-and-nationwide-projections-results-of-the-hypos-1-study
#13
C B Giorda, M C Rossi, O Ozzello, S Gentile, A Aglialoro, A Chiambretti, F Baccetti, F M Gentile, F Romeo, G Lucisano, A Nicolucci
BACKGROUND AND AIMS: To obtain an accurate picture of the total costs of hypoglycemia, including the indirect costs and comparing the differences between type 1 (T1DM) and type 2 diabetes mellitus (T2DM). METHODS AND RESULTS: HYPOS-1 was a multicenter, retrospective cohort study which analyzed the data of 2229 consecutive patients seen at 18 diabetes clinics. Data on healthcare resource use and indirect costs by diabetes type were collected via a questionnaire. The domains of inpatient admission and hospital stay, work days lost, and third-party assistance were also explored...
November 18, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28005998/establishment-of-a-3d-in-vitro-model-to-accelerate-the-development-of-human-therapies-against-corneal-diabetes
#14
Shrestha Priyadarsini, Akhee Sarker-Nag, Tyler G Rowsey, Jian-Xing Ma, Dimitrios Karamichos
PURPOSE: To establish an in vitro model that would mirror the in vivo corneal stromal environment in diabetes (DM) patients. METHODS: Human corneal fibroblasts from Healthy (HCFs), Type 1DM (T1DM) and Type 2DM (T2DM) donors were isolated and cultured for 4 weeks with Vitamin C stimulation in order to allow for extracellular matrix (ECM) secretion and assembly. RESULTS: Our data indicated altered cellular morphology, increased cellular migration, increased ECM assembly, and severe mitochondrial damage in both T1DM and T2DMs when compared to HCFs...
2016: PloS One
https://www.readbyqxmd.com/read/28004007/clinical-efficacy-of-two-different-methods-to-initiate-sensor-augmented-insulin-pumps-a-randomized-controlled-trial
#15
Jesus Moreno-Fernandez, Francisco Javier Gómez, Maria Ángeles Gálvez Moreno, Justo P Castaño
Aim. To analyze clinical effect of a novel approach to initiate sensor-augmented insulin pumps in type 1 diabetes mellitus (T1DM) patients through early real-time continuous glucose monitoring (RT-CGM) initiation. Methods. A 26-week pilot study with T1DM subjects randomized (1 : 1) to start RT-CGM three weeks before continuous subcutaneous insulin infusion (CGM pre-CSII) or adding RT-CGM three weeks after continuous subcutaneous insulin infusion (CGM post-CSII). Results. Twenty-two patients were enrolled with a mean age of 36...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27998794/effects-of-troxerutin-on-cognitive-deficits-and-glutamate-cysteine-ligase-subunits-in-the-hippocampus-of-streptozotocin-induced-type-1-diabetes-mellitus-rats
#16
Songyun Zhang, Hongyan Li, Lihui Zhang, Jie Li, Ruiying Wang, Mian Wang
Increasing evidence demonstrates an association between diabetes and hippocampal neuron damage. This study aimed to determine the effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits (GCLM and GCLC) in the hippocampus of streptozotocin-induced type 1 diabetes mellitus (T1DM) rats. At 12 weeks after streptozotocin injection, T1DM rats were randomly divided into 4 groups (n=15 each group) to receive no treatment (T1DM), saline (T1DM+saline), alpha-lipoic acid (T1DM+alpha-lipoic acid), and troxerutin (T1DM+troxerutin), respectively, for 6 weeks...
December 17, 2016: Brain Research
https://www.readbyqxmd.com/read/27995595/fear-of-self-injecting-and-self-testing-and-the-related-risk-factors-in-adolescents-with-type-1-diabetes-a-cross-sectional-study
#17
Ayman A Al Hayek, Asirvatham A Robert, Saleha Babli, Khuloud Almonea, Mohamed A Al Dawish
INTRODUCTION: This study was conducted to investigate the fear of self-injecting and self-testing and its related risk factors among adolescents with type 1 diabetes mellitus (T1DM). METHODS: From December 2015 to April 2016, a cross-sectional study was performed at the Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia on 142 registered T1DM patients between 13 and 19 years of age. Selection of the respondents was done deliberately and carefully, and the suitable patients were given specific identification numbers...
December 19, 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27995574/metabolite-variation-in-lean-and-obese-streptozotocin-stz-induced-diabetic-rats-via-1-h-nmr-based-metabolomics-approach
#18
Azliana Abu Bakar Sajak, Ahmed Mediani, Maulidiani, Amin Ismail, Faridah Abas
Diabetes mellitus (DM) is considered as a complex metabolic disease because it affects the metabolism of glucose and other metabolites. Although many diabetes studies have been conducted in animal models throughout the years, the pathogenesis of this disease, especially between lean diabetes (ND + STZ) and obese diabetes (OB + STZ), is still not fully understood. In this study, the urine from ND + STZ, OB + STZ, lean/control (ND), and OB + STZ rats were collected and compared by using (1)H NMR metabolomics...
December 19, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27992493/clinical-and-metabolic-characteristics-among-mexican-children-with-different-types-of-diabetes-mellitus
#19
María Lola Evia-Viscarra, Rodolfo Guardado-Mendoza, Edel Rafael Rodea-Montero
BACKGROUND: Current classification of diabetes mellitus (DM) is based on etiology and includes type 1 (T1DM), type 2 (T2DM), gestational, and other. Clinical and pathophysiological characteristics of T1DM and T2DM in the same patient have been designated as type 1.5 DM (T1.5DM). OBJECTIVES: The aim of this study was to classify pediatric patients with DM based on pancreatic autoimmunity and the presence or absence of overweight/obesity, and to compare the clinical, anthropometric, and biochemical characteristics between children in the different classes of DM...
2016: PloS One
https://www.readbyqxmd.com/read/27987236/evaluation-of-the-counter-regulatory-responses-to-hypoglycemia-in-patients-with-type-1-diabetes-during-opiate-receptor-blockade-with-naltrexone
#20
Sarita Naik, Renata Belfort-DeAguiar, Anne-Sophie Sejling, Barbara Szepietowska, Robert S Sherwin
AIMS: Hypoglycemia is the major limiting factor in achieving optimal glycemic control in people with type 1 diabetes (T1DM), especially intensively treated patients with impaired glucose counterregulation during hypoglycemia. Naloxone, an opiate receptor blocker, has been reported to enhance the acute counterregulatory response to hypoglycemia when administered intravenously in humans. The current study was undertaken to investigate if the oral formulation of the long acting opiate antagonist, naltrexone, could have a similar effect, and thus might be useful therapeutically in T1DM patients with a high risk for hypoglycemia...
December 17, 2016: Diabetes, Obesity & Metabolism
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