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https://www.readbyqxmd.com/read/28319803/social-economic-costs-of-type-1-diabetes-mellitus-in-pediatric-patients-in-spain-chrystal-observational-study
#1
Julio López-Bastida, Juan Pedro López-Siguero, Juan Oliva-Moreno, Magaly Perez-Nieves, Renata Villoro, Tatiana Dilla, María Merino, Dingfeng Jiang, Isaac Aranda-Reneo, Jesús Reviriego, Luis Alberto Vázquez
AIMS: To estimate the social-economic costs of Type 1 Diabetes Mellitus (T1DM) in patients aged 0-17years in Spain from a social perspective. METHODS: We conducted a cross-sectional observational study in 2014 of 275 T1DM pediatric outpatients distributed across 12 public health centers in Spain. Data on demographic and clinical characteristics, healthcare utilization and informal care were collected from medical records and questionnaires completed by clinicians and patients' caregivers...
March 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28318105/metformin-as-add-on-to-intensive-insulin-therapy-in-type-1-diabetes-mellitus
#2
Frederik Staels, Carolien Moyson, Chantal Mathieu
We aimed to evaluate the effect of adjuvant metformin to intensive insulin therapy in patients with type 1 diabetes (T1DM). A 10 year retrospective study of 2 cohorts was performed. Cohort "MET" (n = 186) consisted of T1DM patients on adjuvant metformin for ≥ 6 months and cohort "CTR" (n = 62) consisted of T1DM patients who refused (n = 25) or adhered <6 months (n = 37) to metformin. HbA1c, BMI and daily insulin dose were registered yearly. A third cross-sectional group "REF" (n = 961) of T1DM patients not offered adjuvant metformin, was used as a reference for baseline comparison...
March 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28304146/liraglutide-acutely-suppresses-glucagon-lipolysis-and-ketogenesis-in-type-1-diabetes
#3
Manisha Garg, Husam Ghanim, Nitesh D Kuhadiya, Kelly Green, Jeanne Hejna, Sanaa Abuaysheh, Barrett Torre, Manav Batra, Antoine Makdissi, Ajay Chaudhuri, Paresh Dandona
In view of the occurrence of diabetic ketoacidosis associated with the use of sodium-glucose transport protein-2 (SGLT2) inhibitors in patients with type 1 diabetes (T1DM) and the relative absence of this complication in patients treated with liraglutide in spite of reductions in insulin doses, we investigated the effect of liraglutide on ketogenesis. Twenty-six patients with inadequately controlled T1DM were randomly divided into two groups of 13 patients each. After an overnight fast, patients were injected, subcutaneously, with either liraglutide 1...
March 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28302354/quadrant-analysis-of-quantitative-computed-tomography-scans-of-the-femoral-neck-reveals-superior-region-specific-weakness-in-young-and-middle-aged-men-with-type-1-diabetes-mellitus
#4
Takuma Kuroda, Koji Ishikawa, Takashi Nagai, Tomoyasu Fukui, Tsutomu Hirano, Katsunori Inagaki
We have previously shown that the intertrochanter of young and middle-aged patients with type 1 diabetes mellitus (T1DM) showed higher buckling ratio (an index of cortical instability) and lower volumetric bone mineral density (vBMD). However, we have not yet reported the detailed findings regarding the mechanical and density properties of the femoral neck. Therefore, we present a subanalysis of our previous study with the aim of further evaluating the middle third of the femoral neck via quadrant quantitative computed tomography in young and middle-aged patients with T1DM...
March 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28296467/comparison-of-insulin-pump-therapy-and-multiple-daily-injections-insulin-regimen-in-patients-with-type-1-diabetes-during-ramadan-fasting
#5
Reem Alamoudi, Maram Alsubaiee, Ali Alqarni, Yousef Saleh, Saleh Aljaser, Abdul Salam, Mohsen Eledrisi
INTRODUCTION: Fasting Ramadan carries a high risk for patients with type 1 diabetes (T1DM). Data on the optimum insulin regimen in these patients are limited. OBJECTIVES: To compare glucose profiles in patients with T1DM who use continuous subcutaneous insulin infusion (CSII) compared with those who use multiple daily injections (MDI) insulin regimen during Ramadan fast. The primary outcome was rates of hypoglycemia. Other outcomes included glycemic control, number of days needed to break fasting, and acute glycemic complications...
March 15, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28283222/correlation-between-serum-interleukin-6-level-and-type-1-diabetes-mellitus-a-systematic-review-and-meta-analysis
#6
Yin-Ling Chen, Yong-Chao Qiao, Yan-Hong Pan, Yan Xu, Yong-Cheng Huang, Yin-Hui Wang, Li-Jun Geng, Hai-Lu Zhao, Xiao-Xi Zhang
OBJECTIVE: This report aimed to explore the association between the change of circulating interleukin-6 (IL-6) in patients and the development of type 1 diabetes mellitus (T1DM). METHODS: Four databases (PubMed, CNKI, WanFang and Civip) were used to search and list all clinical case-control studies about serum IL-6 level in T1DM patients between Jan 1, 2000 and Aug 31, 2016. RESULTS: A total of 20 case-control studies with 1238 T1DM patients and 742 healthy controls were included in this study...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28283030/impaired-osteogenesis-of-t1dm-bone-marrow-derived-stromal-cells-and-periosteum-derived-cells-and-their-differential-in-vitro-responses-to-growth-factor-rescue
#7
Tera M Filion, Jordan D Skelly, Henry Huang, Dale L Greiner, David C Ayers, Jie Song
BACKGROUND: Poor bone quality, increased fracture risks, and impaired bone healing are orthopedic comorbidities of type 1 diabetes (T1DM). Standard osteogenic growth factor treatments are inadequate in fully rescuing retarded healing of traumatic T1DM long bone injuries where both periosteal and bone marrow niches are disrupted. We test the hypotheses that osteogenesis of bone marrow-derived stromal cells (BMSCs) and periosteum-derived cells (PDCs), two critical skeletal progenitors in long bone healing, are both impaired in T1DM and that they respond differentially to osteogenic bone morphogenetic proteins (BMPs) and/or insulin-like growth factor-1 (IGF-1) rescue...
March 11, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28280962/fear-of-hypoglycemia-parenting-stress-and-metabolic-control-for-children-with-type-1-diabetes-and-their-parents
#8
Ann-Sofie Viaene, Tom Van Daele, Dries Bleys, Kelly Faust, Guy G Massa
This study sets out to extend current knowledge of parenting stress and fear of hypoglycemia (FoH) in parents of children with type 1 diabetes mellitus (T1DM). We examined if the relationship between parental and children's FoH and metabolic control, as reflected by HbA1c, is mediated by parenting stress. A total of 63 parents and children with T1DM were recruited during their routine physician's appointment. Parents completed questionnaires on parenting stress and FoH. Children eight years and older also completed a questionnaire on FoH...
March 9, 2017: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/28276512/the-efficacy-and-safety-of-sglt2-inhibitors-for-adjunctive-treatment-of-type-1-diabetes-a-systematic-review-and-meta-analysis
#9
Jiao Chen, Fang Fan, J Y Wang, Yang Long, C L Gao, R C Stanton, Yong Xu
To assess the efficacy and safety of the SGLT-2 inhibitors as adjunct therapy to insulin in T1DM, clinical trials indexed in PubMed, Cochrane Library, EMbase from inception through April 5, 2016. A meta-analysis was conducted on trials of SGLT-2 inhibitors in patients with T1DM on insulin therapy using RevMan 5.3 software. Of the 371 articles identified, ten met eligibility criteria. Seven clinical trials including four randomized controlled trials and 581 patients were included. Compared with the control group, SGLT-2 inhibitors group had significantly reduced fasting plasma glucose by 0...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274344/the-prevalence-of-diabetes-mellitus-and-abnormal-glucose-metabolism-in-the-inpatient-psychiatric-setting-a-systematic-review-and-meta-analysis
#10
REVIEW
Emmert Roberts, Leah Jones, Alexandra Blackman, Thomas Dewhurst, Faith Matcham, Carol Kan, Omar Mustafa, Toral Thomas, Najma Siddiqi, Khalida Ismail, Hermione Price
OBJECTIVE: To systematically determine the prevalence of diabetes mellitus (DM), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) in psychiatric inpatients and explore the impact of patient and study variables on prevalence estimates. METHOD: We searched EMBASE, PsychINFO, Medline and CENTRAL from database inception until 1st December 2015. We included studies of any design reporting prevalence of abnormal glucose metabolism in any adult psychiatric inpatients...
March 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28273469/should-i-stay-or-should-i-go-a-clash-of-%C3%AE-cell-identity
#11
Maria S Remedi
Understanding mechanisms for maintaining pancreatic islet cell fate and function is important for addressing the urgent challenge of restoring islet β- and α-cell function in T1DM. In this issue of Cell Metabolism, Chakravarthy et al. (2017) identify a genetic mechanism by which mouse β-cells are spontaneously regenerated from adult α-cells.
March 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28270484/differences-in-incidence-of-diabetic-retinopathy-between-type-1-and-2-diabetes-mellitus-a-nine-year-follow-up-study
#12
Pedro Romero-Aroca, Raul Navarro-Gil, Aida Valls-Mateu, Ramon Sagarra-Alamo, Antonio Moreno-Ribas, Nuria Soler
BACKGROUND/AIMS: To determine the incidence of any diabetic retinopathy (any-DR), sight-threatening diabetic retinopathy (STDR) and diabetic macular oedema (DMO) and their risk factors in type 1 diabetes mellitus (T1DM) over a screening programme. METHODS: Nine-year follow-up, prospective population-based study of 366 patients with T1DM and 15 030 with T2DM. Epidemiological risk factors were as follows: current age, age at DM diagnosis, sex, type of DM, duration of DM, arterial hypertension, levels of glycosylated haemoglobin (HbA1c), triglycerides, cholesterol fractions, serum creatinine, estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR)...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28269053/deep-learning-framework-for-detection-of-hypoglycemic-episodes-in-children-with-type-1-diabetes
#13
Phyo Phyo San, Sai Ho Ling, Hung T Nguyen
Most Type 1 diabetes mellitus (T1DM) patients have hypoglycemia problem. Low blood glucose, also known as hypoglycemia, can be a dangerous and can result in unconsciousness, seizures and even death. In recent studies, heart rate (HR) and correct QT interval (QTc) of the electrocardiogram (ECG) signal are found as the most common physiological parameters to be effected from hypoglycemic reaction. In this paper, a state-of-the-art intelligent technology namely deep belief network (DBN) is developed as an intelligent diagnostics system to recognize the onset of hypoglycemia...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265345/exercise-induced-albuminuria-vs-circadian-variations-in-blood-pressure-in-type-1-diabetes
#14
Isabelle Hota Tadida Meli, Aurel T Tankeu, Mesmin Y Dehayem, David Chelo, Jean Jacques N Noubiap, Eugene Sobngwi
AIM: To investigated the relationship between exercise-induced ambulatory blood pressure measurement (ABPM) abnormalities in type 1 diabetes mellitus (T1DM) adolescents. METHODS: We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio (ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1DM patients and 20 matched controls. T1DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure (BP) and renal function according to the general reference population...
February 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28263096/glutamine-dipeptide-and-cortisol-change-the-liver-glucose-metabolism-and-reduce-the-severity-of-insulin-induced-hypoglycaemia-in-untreated-t1dm-swiss-mice
#15
Camila Bataglini, Diego G L Rezende, Marcos A Primo, Célia R G Gomes, Maria M D Pedrosa, Vilma A F Godoi
CONTEXT: Glutamine is conditionally essential in type 1 diabetes mellitus, and might be useful to counteract hypoglycaemia. OBJECTIVE: To investigate the systemic and hepatic effects of counter-regulatory hormones and glutamine dipeptide (GDP) during hypoglycemic episodes. MATERIALS AND METHODS: Diabetic Swiss mice made hypoglycaemic by insulin injection (1 U/kg) were given counter-regulatory hormones and/or GDP. Sixty minutes later, liver histology, liver glucose metabolism and plasma were assessed...
May 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28260302/-insulin-regimes-and-impact-on-glycemic-control-in-patients-with-type-1-diabetes
#16
J H Yan, Y Zhang, X Y Zheng, S H Luo, H Y Ai, J Lü, L L Qiu, X W Zhang, D Z Yang, B Yao, J P Weng
Objective: To describe the insulin regimens and their associations with glycemic control and to explore factors associated with intensive insulin therapy. Methods: Patients with type 1 diabetes (T1DM) were recruited from Guangdong Type 1 Diabetes Mellitus Translational Medicine Study which was conducted in 16 centers in Guangdong province. The demographic and clinical data were collected. Patients were grouped according to different insulin regimens: insulin pump (R1), basal insulin plus regular insulin or short-acting insulin (R2), insulin injection 1-3 times per day (R3)...
February 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28256088/prevalence-of-elevated-liver-enzymes-in-adults-with-type-1-diabetes-a-multicenter-analysis-of-the-german-austrian-dpv-database
#17
Marietta Stadler, Esther Bollow, Maria Fritsch, Wolfgang Kerner, Ingrid Schuetz-Fuhrmann, Dietmar Krakow, Sigrun Merger, Michaela Riedl, Peter Jehle, Reinhard W Holl
AIMS: To assess the prevalence of elevated liver enzymes in adults with type 1 diabetes mellitus (T1DM) in routine clinical care and the association with cardiovascular risk profile in the Diabetes-Prospective-Documentation (DPV) network in Germany and Austria. METHODS: This cross sectional observational study from the DPV registry includes data from 45519 adults with T1DM at 478 centers up to 9/2016. Liver enzyme measurements were available in 9226 (29%) patients at 270 centers and were analyzed for increased alanine aminotransferase (ALT; men > 50 U/l, women: >35U/l) and/or aspartate aminotransferase (AST; men >50 U/l, women >35U/l) and/or gamma-glutamyltransferase (GGT; men >60U/l, women > 40 U/l)...
March 2, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28255273/increase-in-peripheral-blood-intermediate-monocytes-is-associated-with-the-development-of-recent-onset-type-1-diabetes-mellitus-in-children
#18
Xiaoya Ren, Wenjun Mou, Chang Su, Xi Chen, Hui Zhang, Bingyan Cao, Xiaoqiao Li, Di Wu, Xin Ni, Jingang Gui, Chunxiu Gong
Monocytes play important roles in antigen presentation and cytokine production to achieve a proper immune response, and are therefore largely implicated in the development and progression of autoimmune diseases. The aim of this study was to analyze the change in the intermediate (CD14+CD16+) monocyte subset in children with recent-onset type 1 diabetes mellitus (T1DM) and its possible association with clinical parameters reflecting islet β-cell dysfunction. Compared with age- and sex-matched healthy controls, intermediate monocytes were expanded in children with T1DM, which was positively associated with hemoglobin A1C and negatively associated with serum insulin and C-peptide...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28246144/population-trends-in-the-10-year-incidence-and-prevalence-of-diabetic-retinopathy-in-the-uk-a-cohort-study-in-the-clinical-practice-research-datalink-2004-2014
#19
Rohini Mathur, Krishnan Bhaskaran, Emma Edwards, Helen Lee, Nishi Chaturvedi, Liam Smeeth, Ian Douglas
OBJECTIVES: To describe trends in the incidence and prevalence of diabetic retinopathy (DR) in the UK by diabetes type, age, sex, ethnicity, deprivation, region and calendar year. DESIGN: Cohort study using the Clinical Practice Research Datalink (CPRD). SETTING: UK primary care. PARTICIPANTS: 7.7 million patients ≥12 contributing to the CPRD from 2004 to 2014. PRIMARY AND SECONDARY OUTCOME MEASURES: Age-standardised prevalence and incidence of diabetes, DR and severe DR (requiring photocoagulation) by calendar year and population subgroup...
February 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28242376/cell-based-therapeutics-in-type-1-diabetes-mellitus
#20
Fernanda Zamboni, Maurice N Collins
This review focuses on Type 1 diabetes mellitus (T1DM) and the role of bioengineering, nanotechnology and cell therapy in its treatment. T1DM is discussed in terms of its prevalence as well as the role of the extra cellular matrix (ECM) of the pancreas in its development and mode of action. Surface engineering strategies and the chemistries behind important cell encapsulation techniques, which are emerging from recent research in immunosuppression, are described. Key enabling technologies such as therapeutic agent immobilization on cells, oxygen releasing systems, gene delivery and bio imaging are assessed with respect to T1DM...
February 27, 2017: International Journal of Pharmaceutics
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