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https://www.readbyqxmd.com/read/28735424/a-novel-3d-anatomic-mapping-approach-using-multipoint-high-density-voltage-gradient-mapping-to-quickly-localize-and-terminate-typical-atrial-flutter
#1
William C Choe, Sri Sundaram, J Ryan Jordan, Nate Mullins, Charles Boorman, Austin Davies, Alex C Tiftickjian, Sunil Nath
PURPOSE: The purposes of the study were to evaluate and characterize the cavotricuspid isthmus using multipoint high density voltage gradient mapping (HD-VGM) to see if this would improve on current ablation techniques compared to standard cavotricuspid isthmus ablation techniques. METHODS: Group 1, 25 patients who underwent ablation using standard methods of 3D mapping and ablation, was compared to group 2, 33 patients undergoing ablation using HD-VGM and ablation...
July 22, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28735397/global-proteomic-profiling-and-identification-of-stress-responsive-proteins-using-two-dimensional-gel-electrophoresis
#2
Pragya Barua, Dipak Gayen, Nilesh Vikram Lande, Subhra Chakraborty, Niranjan Chakraborty
Global proteome profiling is a direct representation of the protein set in an organism, organ, tissues, or an organelle. One of the main objectives of proteomic analysis is the comparison and relative quantitation of proteins under a defined set of conditions. Two-dimensional gel electrophoresis (2-DE) has gained prominence over the last 4 decades for successfully aiding differential proteomics, providing visual confirmation of changes in protein abundance, which otherwise cannot be predicted from genome analysis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735317/genetic-characterization-of-a-novel-composite-transposon-carrying-arma-and-aac-6-ib-genes-in-an-escherichia-coli-isolate-from-egypt
#3
Mona T Kashef, Omneya M Helmy
Aminoglycosides are used in treating a wide range of infections caused by Gram-positive and Gram-negative bacteria; however, aminoglycoside resistance is common and occurs by several mechanisms. Among these mechanisms is bacterial rRNA methylation by the 16S rRNA methyl transferase (16S-RMTase) enzymes; but data about the spread of this mechanism in Egypt are scarce. Cephalosporins are the most commonly used antimicrobial agents in Egypt; therefore, this study was conducted to determine the frequency of 16S-RMTase among third generation cephalosporin-resistant clinical isolates in Egypt...
July 6, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28735055/molecular-analysis-of-virulence-genes-and-the-accessory-gene-regulator-agr-types-among-methicillin-resistant-staphylococcus-aureus-mrsa-strains
#4
Sara Cheraghi, Leyla Pourgholi, Maryam Shafaati, Shirinsadat Hashemi Fesharaki, Arash Jalali, Rahim Nosrati, MohammadAli Boroumand
OBJECTIVES: Methicillin resistant S. aureus (MRSA) strains are a main cause of hospital-acquired infections and are considered as a serious public-health concern. MRSA isolates have plenty of virulence factors, which are the basis for its pathogenicity. The controlling and coordination of the expression of these genes perform by the accessory gene regulator (agr). The aim of this study was to determine the rate of some virulence genes encoding the enterotoxin, exfoliative toxin genes (eta), the adhesin genes and identification of agr specificity groups in MRSA isolates...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28735013/simultaneous-intrinsic-signal-imaging-of-auditory-and-visual-cortex-reveals-profound-effects-of-acute-hearing-loss-on-visual-processing
#5
Manuel Teichert, Jürgen Bolz
It has been suggested that primary sensory cortices do not work in isolation but receive subthreshold inputs originating from other senses. However, repercussions of an acute loss of one sense on multimodal sensory processing remain elusive. Here we investigated the early effects of acute hearing loss on visual processing in adult mice. For this, we developed a method to simultaneously map the primary auditory (A1) and visual cortex (V1) using periodic intrinsic optical imaging. We found that reducing sound evoked A1 responsiveness due to the induction of conductive hearing loss (CHL) led to a concomitant increase of visually driven V1 activity...
July 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28735011/assessment-and-elimination-of-the-effects-of-head-movement-on-meg-resting-state-measures-of-oscillatory-brain-activity
#6
Eirini Messaritaki, Loes Koelewijn, Diana C Dima, Gemma M Williams, Gavin Perry, Krish D Singh
Magnetoencephalography (MEG) is increasingly being used to study brain function because of its excellent temporal resolution and its direct association with brain activity at the neuronal level. One possible cause of error in the analysis of MEG data comes from the fact that participants, even MEG-experienced ones, move their head in the MEG system. Head movement can cause source localization errors during the analysis of MEG data, which can result in the appearance of source variability that does not reflect brain activity...
July 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28734955/predicting-the-nodal-status-in-gastric-cancers-the-role-of-apparent-diffusion-coefficient-histogram-characteristic-analysis
#7
Song Liu, Yujuan Zhang, Jie Xia, Ling Chen, Wenxian Guan, Yue Guan, Yun Ge, Jian He, Zhengyang Zhou
PURPOSE: To explore the application of histogram analysis in preoperative T and N staging of gastric cancers, with a focus on characteristic parameters of apparent diffusion coefficient (ADC) maps. MATERIALS AND METHODS: Eighty-seven patients with gastric cancers underwent diffusion weighted magnetic resonance imaging (b=0, 1000s/mm(2)), which generated ADC maps. Whole-volume histogram analysis was performed on ADC maps and 7 characteristic parameters were obtained...
July 19, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28734874/robotic-assistants-in-personal-care-a-scoping-review
#8
REVIEW
A Bilyea, N Seth, S Nesathurai, H A Abdullah
The aim of this study is to present an overview of the technological advances in the field of robotics developed for assistance with activities of daily living (ADL), and to present areas where further research is required. Four databases were searched for articles presenting either a novel design of one of these personal care robotic system or trial results relating to these systems. Articles presenting nine different robotic personal care systems were examined, six of which had been developed after 2005. These six also all have publications relating to their trials...
July 19, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28734854/pulse-pressure-variation-as-a-guide-for-volume-expansion-in-dogs-undergoing-orthopedic-surgery
#9
Denise T Fantoni, Keila K Ida, André M Gimenes, Matheus M Mantovani, Jacqueline R Castro, Geni C F Patrício, Aline M Ambrósio, Denise A Otsuki
OBJECTIVE: To investigate whether pulse pressure variation (PPV) can predict fluid responsiveness in healthy dogs during clinical surgery. STUDY DESIGN: Prospective clinical study. ANIMALS: Thirty-three isoflurane-anesthetized dogs with arterial hypotension during orthopedic surgery. METHODS: Fluid challenge with lactated Ringer's solution (15 mL kg(-1) in 15 minutes) was administered in mechanically ventilated dogs (tidal volume 10 mL kg(-1)) with hypotension [mean arterial pressure (MAP) < 65 mmHg]...
March 22, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28734853/the-impact-of-mk-467-on-sedation-heart-rate-and-arterial-blood-pressure-after-intramuscular-coadministration-with-dexmedetomidine-in-conscious-cats
#10
Juhana Honkavaara, Bruno Pypendop, Jan Ilkiw
OBJECTIVE: To study the effects of MK-467, a peripheral α2-adrenoceptor antagonist, on sedation, heart rate and blood pressure after intramuscular (IM) coadministration with 25 μg kg(-1) of dexmedetomidine in cats. STUDY DESIGN: Prospective, randomized, controlled, blinded, cross-over, experimental study. ANIMALS: A total of eight healthy, adult, neutered male cats. METHODS: Cats were administered five IM treatments at least 2 weeks apart, consisting of dexmedetomidine 25 μg kg(-1) (D25), MK-467 600 μg kg(-1) (M600) and D25 combined with 300, 600 and 1200 μg kg(-1) of MK-467 (D25M300, D25M600 and D25M1200, respectively)...
March 22, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28734812/quantitative-retinal-vascular-changes-in-obstructive-sleep-apnea
#11
Jessica Y Tong, Mojtaba Golzan, Dana Georgevsky, Jonathan P Williamson, Stuart L Graham, Claude S Farah, Clare L Fraser
PURPOSE: To examine the relationship between both static and dynamic retinal vascular caliber and the severity of obstructive sleep apnea (OSA). DESIGN: Prospective cross-sectional study. METHODS: Adult patients undergoing diagnostic polysomnography studies at a private Australian university teaching hospital were recruited. OSA severity was defined by the apnea-hypopnea index (AHI): severe >30, moderate >15-30, mild 5-15, and controls <5...
July 19, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28734799/eeg-analysis-of-seizure-patterns-using-visibility-graphs-for-detection-of-generalized-seizures
#12
Lei Wang, Xi Long, Johan B A M Arends, Ronald M Aarts
BACKGROUND: The traditional EEG features in the time and frequency domain show limited seizure detection performance in the epileptic population with intellectual disability (ID). In addition, the influence of EEG seizure patterns on detection performance was less studied. NEW METHOD: A single-channel EEG signal can be mapped into visibility graphs (VGS), including basic visibility graph (VG), horizontal VG (HVG), and difference VG (DVG). These graphs were used to characterize different EEG seizure patterns...
July 19, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28734777/inhibitor-mechanisms-in-the-s1-binding-site-of-the-dopamine-transporter-defined-by-multi-site-molecular-tethering-of-photoactive-cocaine-analogs
#13
Danielle Krout, Akula Bala Pramod, Rejwi Acharya Dahal, Michael J Tomlinson, Babita Sharma, James D Foster, Mu-Fa Zou, Comfort Boatang, Amy Hauck Newman, John R Lever, Roxanne A Vaughan, L Keith Henry
Dopamine transporter (DAT) blockers like cocaine and many other abused and therapeutic drugs bind and stabilize an inactive form of the transporter inhibiting reuptake of extracellular dopamine (DA). The resulting increases in DA lead to the ability of these drugs to induce psychomotor alterations and addiction, but paradoxical findings in animal models indicate that not all DAT antagonists induce cocaine-like behavioral outcomes. How this occurs is not known, but one possibility is that uptake inhibitors may bind at multiple locations or in different poses to stabilize distinct conformational transporter states associated with differential neurochemical endpoints...
July 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28734702/impact-of-hypotension-after-return-of-spontaneous-circulation-on-survival-in-patients-of-out-of-hospital-cardiac-arrest
#14
Yu Koon Chiu, Chun Tat Lui, Kwok Leung Tsui
OBJECTIVE: To investigate the relationship between hypotension in the first 3h after return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest. METHOD: This retrospective cohort study occurred at two regional hospitals and included adult OHCA patients who experienced ROSC from July 1, 2014 to December 31, 2015. Hemodynamic and inotrope administration data were retrieved for 3h after ROSC. We calculated the hypotensive exposure index (HEI) as the surrogate marker of the exposure of hypotension...
July 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28734530/joint-optic-disc-and-cup-boundary-extraction-from-monocular-fundus-images
#15
Arunava Chakravarty, Jayanthi Sivaswamy
BACKGROUND AND OBJECTIVE: Accurate segmentation of optic disc and cup from monocular color fundus images plays a significant role in the screening and diagnosis of glaucoma. Though optic cup is characterized by the drop in depth from the disc boundary, most existing methods segment the two structures separately and rely only on color and vessel kink based cues due to the lack of explicit depth information in color fundus images. METHODS: We propose a novel boundary-based Conditional Random Field formulation that extracts both the optic disc and cup boundaries in a single optimization step...
August 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28734351/capillary-electrophoresis-tandem-mass-spectrometry-as-a-highly-selective-tool-for-the-compositional-and-site-specific-assessment-of-multiple-peptide-deamidation
#16
Elena Dominguez-Vega, Thomas De Vijlder, Edwin P Romijn, Govert W Somsen
Site-specific mapping of multiple deamidations in peptides is a challenging analytical task. In this work, capillary electrophoresis-tandem mass spectrometry (CE-MS/MS) is presented as a high-resolution tool for the detailed characterization of these subtle modifications in peptides. The 4.5-kDa peptide drug TRI-1144, which contains five closely-positioned potential deamidation sites, was selected as model compound. TRI-1144 was exposed to acidic conditions and/or elevated temperatures for 1-14 h. Stressed samples were analyzed using a background electrolyte (BGE) of 150 mM ammonium formate (pH 6...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734205/identification-of-mycobacterium-tuberculosis-enoyl-acyl-carrier-protein-reductase-inhibitors-a-combined-in-silico-and-in-vitro-analysis
#17
Mohsin Y Lone, Mohd Athar, Vivek K Gupta, Prakash C Jha
Mycobacterium tuberculosis (Mtb), had developed evolutionary changes in its genome to adapt for survival and thereby generated multi-drug resistant strains. However, novel drug targets that remained unchanged for their biochemical role has impressed the research community to target such proteins. The comprehensive analysis of multiple protein targets has influenced us to make a consensus structural rule exploited by pharmacophore and other allied techniques from a large repository of protein structures. In this pursuit, we made a retrospective analysis of pharmacophores mapped from the tuberculosis structural proteome and identified unique patterns that can be employed for the novel molecules design...
July 14, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28734132/high-dimensional-single-cell-mapping-of-cerium-distribution-in-the-lung-immune-microenvironment-of-an-active-smoker
#18
Adeeb H Rahman, Yonit Lavin, Soma Kobayashi, Andrew Leader, Miriam Merad
BACKGROUND: Mass cytometry leverages inductively coupled mass spectrometry to perform high dimensional single cell analyses using antibodies tagged with rare earth isotopes that are considered to be largely absent in biological samples. We have recently noted an unusual exception to this rule while analyzing tissue samples from patients undergoing surgical resection for early stage lung cancer, and here we present a detailed cytometric characterization of cerium in a clinical patient sample...
July 22, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28733917/evaluation-of-a-modified-triple-p-procedure-in-women-with-morbidly-adherent-placenta-after-previous-caesarean-section
#19
Yanxing Wei, Yanwen Cao, Yanhong Yu, Zhijian Wang
AIM: To describe a modified "Triple-P" procedure and evaluate its outcome in women with morbidly adherent placenta (MAP) after previous caesarean section (CS). METHODS: A retrospective cohort study of 96 women with MAP after CS was recruited with 45 women receiving the modified "Triple-P" procedure as study group and the other 51 cases receiving the conventional managements as the control. The maternal outcomes were compared. RESULTS: The modified "Triple-P" procedure was described in step by step...
July 21, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28733852/wax-crystal-sparse-leaf-4-encoding-a-%C3%AE-ketoacyl-coenzyme-a-synthase-6-is-involved-in-rice-cuticular-wax-accumulation
#20
Lu Gan, Shanshan Zhu, Zhichao Zhao, Linglong Liu, Xiaole Wang, Zhe Zhang, Xin Zhang, Jie Wang, Jiulin Wang, Xiuping Guo, Jianmin Wan
WSL4 encodes a KCS6 protein which is required for cuticular wax accumulation in rice. Very long chain fatty acids (VLCFAs) are essential precursors for cuticular wax biosynthesis. VLCFA biosynthesis occurs in the endoplasmic reticulum and requires the fatty acid elongase (FAE) complex. The β-ketoacyl-coenzyme A synthase (KCS) catalyzes the first step of FAE-mediated VLCFA elongation. Here we characterized the Wax Crystal-Sparse Leaf 4 (WSL4) gene involved in leaf cuticular wax accumulation in rice. The wsl4 mutant displayed a pleiotropic phenotype including dwarfism, less tiller numbers and reduced surface wax load...
July 21, 2017: Plant Cell Reports
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