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https://www.readbyqxmd.com/read/29142429/antioxidant-and-hepatoprotective-potential-of-swaras-and-hima-extracts-of-tinospora-cordifolia-and-boerhavia-diffusa-in-swiss-albino-mice
#1
Amit Kaushik, Athar Husain, Harshika Awasthi, Dewasya Pratap Singh, Raziuddin Khan, Dayanandan Mani
Background: In Ayurveda, five basic extraction procedures are mentioned in order of their decreasing potency. Swaras is considered as the most potent followed by, kalka, kwatha, fanta and hima. Objective: Present study was carried out to investigate the antioxidant and hepatoprotective potential of swaras and hima extracts of T.cordifolia and B. diffusa. Materials and Methods: Swaras and hima extracts of T. cordifolia and B. diffusa were prepared...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29131698/the-anti-inflammatory-and-antioxidant-effects-of-salvia-officinalis-on-lipopolysaccharide-induced-inflammation-in-rats
#2
Umut Kerem Kolac, Mehmet Cengiz Ustuner, Neslihan Tekin, Derya Ustuner, Emine Colak, Emre Entok
Salvia officinalis, which has a high phenolic acid and flavonoid content, is a powerful antioxidant and anti-inflammatory herb. Inflammation plays an important role in the pathophysiology of many diseases and could cause damage by means of oxidative stress. The aim of this study was to investigate the anti-inflammatory and antioxidant activity of S. officinalis formed lipopolysaccharide (LPS)-induced experimental inflammation model. Four- to five-month-old 42 female Wistar albino rats were divided into six groups...
November 13, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29111651/a-series-of-lithium-pyridyl-phenolate-complexes-with-a-pendant-pyridyl-group-for-electron-injection-layers-in-organic-light-emitting-devices
#3
Satoru Ohisa, Taichiro Karasawa, Yuichiro Watanabe, Tatsuya Ohsawa, Yong-Jin Pu, Tomoyuki Koganezawa, Hisahiro Sasabe, Junji Kido
We report a new series of lithium pyridyl phenolate complexes with a pendant pyridyl group, Li2BPP, Li3BPP, and Li4BPP, in which the pendant pyridines are substituted at the 2-, 3-, and 4-positions, respectively. The most important difference between these complexes is their molecular planarity; Li3BPP and Li4BPP adopt twisted bipyridine structures, whereas Li2BPP adopts a planar structure owing to the steric hindrance and chelating effect of bipyridine on the Li core. The planar structure leads to crystallization through π-π stacking interactions, and the small differences in the molecular structures of the pendant pyridine rings cause drastic differences in the physical properties of thin solid films of these complexes...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29105854/simultaneous-determination-and-tissue-distribution-studies-of-four-phenolic-acids-in-rat-tissue-by-uflc-ms-ms-after-intravenous-administration-of-salvianolic-acid-for-injection
#4
Shuang Li, Xiuman Xie, Dongxiang Li, Zhiguo Yu, Ling Tong, Yunli Zhao
A rapid, simple and sensitive ultra-fast liquid chromatography tandem mass spectrometric method was developed and validated for simultaneous determination and tissue distribution studies of rosmarinic acid, salvianolic acid D, lithospermic acid and salvianolic acid B in rats after intravenous administration of salvianolic acid for injection. The tissue homogenate samples were pretreated by protein precipitation with pre-cooled acetonitrile. Chromatographic separation was achieved on a Waters Cortecs UPLC C18 column (1...
November 6, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29105737/enhanced-tissue-adhesiveness-of-injectable-gelatin-hydrogels-through-dual-catalytic-activity-of-horseradish-peroxidase
#5
Thai Thanh Hoang Thi, Yunki Lee, Seung Bae Ryu, Dai Hai Nguyen, Ki Dong Park
Development of bioadhesives with tunable mechanical strength, high adhesiveness, biocompatibility, and injectability is greatly desirable in all surgeries to replace or complement the sutures and staples. Herein, the dual catalytic activity of horseradish peroxidase is exploited to in situ form the hydroxyphenyl propionic acid-gelatin/thiolated gelatin (GH/GS) adhesive hydrogels including two alternative crosslinks (phenol-phenol and disulfide bonds) with fast gelation (few seconds - several minutes) and improved physicochemical properties...
November 6, 2017: Biopolymers
https://www.readbyqxmd.com/read/29098952/a-combination-of-absorption-and-enzymatic-biodegradation-phenol-elimination-from-aqueous-and-organic-phase
#6
Tandjaoui Nassima, Abouseoud Mahmoud, Couvert Annabelle, Amrane Abdeltif, Tassist Amina
Peroxidase from Brassica rapa (BRP) was immobilized as cross-linked enzyme aggregates (CLEAs) and used to treat air containing phenol as a model molecule of volatile organic compounds (VOCs). Prior to enzymatic treatment, phenol was absorbed into aqueous or organic phase (silicone oil, Rhodorsil® 47V20) to reach concentrations ranging from 20 to 160mg/L. The process of enzymatic degradation was carried out by introducing a desired weighing of BRP-CLEAs into preparations and reaction was started by injecting H2O2 solution to medium...
November 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29097839/ethanol-extracts-collected-from-the-styela-clava-tunic-alleviate-hepatic-injury-induced-by-carbon-tetrachloride-ccl4-through-inhibition-of-hepatic-apoptosis-inflammation-and-fibrosis
#7
Eun Kyoung Koh, Ji Eun Kim, Sung Hwa Song, Ji Eun Sung, Hyun Ah Lee, Kil Soo Kim, Jin Tae Hong, Dae Youn Hwang
The Styela clava tunic (SCT) is known as a good raw material for preparing anti-inflammatory compounds, wound healing films, guided bone regeneration, and food additives. To investigate whether ethanol extracts of the SCT (EtSCT) could protect against hepatic injury induced by carbon tetrachloride (CCl4) in ICR mice, alterations in serum biochemical indicators, histopathology, hepatic apoptosis, inflammation, and fibrosis were observed in ICR mice pretreated with EtSCT for 5 days before CCl4 injection. EtSCT contained 15...
October 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29052379/-simultaneous-determination-of-ten-major-compounds-including-iridoid-glycosides-and-phenolic-acids-in-pterocephalus-hookeri-by-uplc-pda
#8
Ce Tang, Jian Wen, Jing Wang, Ke-Hui Zhao, Gang Fan, Xian-Li Meng, Zhong-Mei Zou, Yi Zhang
This study is to develop an UPLC-PDA method for determination of 10 major components in Pterocephalus. The UPLC-PDA assay was performed on a Waters Acquity UPLCR BEH C₁₈(2.1 mm ×100 mm,1.7 μm), and the column temperature was at 30 ℃. The mobile phase consists of water containing 0.2% phosphoric acid (A) and acetonitrile (B) in gradient elution at a flow rate of 0.4 mL•min⁻¹. The detection wave length was set at 237 and 325 nm, and the injection volume was 1 μL in the UPLC system. The linear range of 10 detected compounds were good (r≥0...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29052076/-e-2-methoxy-4-3-4-methoxyphenyl-prop-1-en-1-yl-phenol-ameliorates-lps-mediated-memory-impairment-by-inhibition-of-stat3-pathway
#9
Ji Yeon Choi, Chul Ju Hwang, Do Yeon Lee, Sun Mi Gu, Hee Pom Lee, Dong Young Choi, Ki Wan Oh, Sang-Bae Han, Jin Tae Hong
Alzheimer's disease (AD) is pathologically characterized by an excessive accumulation of amyloid-beta (Aβ) fibrils within the brain. We tested the anti-inflammatory and anti-amyloidogenic effects of (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor. We examined whether MMPP (5 mg/kg in drinking water for 1 month) prevents amyloidogenesis and cognitive impairment on AD model mice induced by intraperitoneal LPS (250 μg/kg daily 7 times) injections...
December 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28993279/anti-scorpion-venom-activity-of-thapsia-garganica-methanolic-extract-histopathological-and-biochemical-evidences
#10
Btissam Bouimeja, Moulay Abdelmonaim El Hidan, Oulaid Touloun, Mehdi Ait Laaradia, Loubna Ait Dra, Noureddine El Khoudri, Abderrahman Chait, Ali Boumezzough
ETHNOPHARMACOLOGICAL RELEVANCE: Thapsia garganica, is a herbal medicine traditionally used as diuretic, emetic and purgative. It is also used as anti-scorpion venom in Morocco; however, its protective effects against scorpion venom remain elusive. AIM OF THE STUDY: The present study was undertaken to evaluate anti-venom activity of T. garganica in vivo through histological and biochemical studies. MATERIALS AND METHODS: Methanolic leaves extract of T...
October 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28969623/protective-effects-of-methanolic-extract-of-juglans-regia-l-leaf-on-streptozotocin-induced-diabetic-peripheral-neuropathy-in-rats
#11
Davood Nasiry, Ali Reza Khalatbary, Hassan Ahmadvand, Fereshteh Talebpour Amiri, Esmaeil Akbari
BACKGROUND: Oxidative stress has a pivotal role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complications of diabetes mellitus. There is accumulating evidence that Juglans regia L. (GRL) leaf extract, a rich source of phenolic components, has hypoglycemic and antioxidative properties. This study aimed to determine the protective effects of Juglans regia L. leaf extract against streptozotocin-induced diabetic neuropathy in rat...
October 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28968925/restoration-of-plasma-markers-of-liver-and-kidney-functions-integrity-in-alloxan-induced-diabetic-rabbits-by-aqueous-extract-of-pleurotus-tuberregium-sclerotia
#12
Catherine Chidinma Ikewuchi, Jude Chigozie Ikewuchi, Mercy Onuekwuzu Ifeanacho
The effect of aqueous extract of the sclerotia of Pleurotus tuberregium on the plasma electrolytes, and markers of liver and kidney functions/integrity of normal and alloxan-induced rabbits was investigated. Diabetes mellitus was induced by injection of alloxan (120mg/kg body weight), via the marginal ear vein. The extract was administered orally at 100, 200 and 300mg/kg (both to normal and diabetic rabbits), and metformin at 50mg/kg. Gas chromatographic-flame ionization detector analysis of the extract revealed the presence of twelve known phenolic acids, consisting mainly of caffeic acid (80...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28936842/-rapid-analysis-on-chemical-constituents-in-yinyanghuo-zonghuangtong-capsule-by-uplc-q-tof-ms-ms
#13
Xue-E Yu, Jian-Ping Qin, Jia-Chun Li, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao
To analyze and identify the chemical constituents from Yinyanghuo Zonghuangtong capsule by using UPLC/Q-TOF-MS/MS. Chromatographic separation was carried out on an Agilent SB-C₁₈ column (2.1 mm×100 mm, 1.8 μm) at the temperature of 30 ℃. The mobile phase was 0.1% formic acid and acetonitrile by gradient elution, with a flow rate at 0.30 mL•min⁻¹, and the injection volume of 2 μL. The MS spectrum was acquired in both negative and positive ion modes using ESI ion source. Based on relative accurate molecular weight, secondary mass spectrometry pyrolysis fragments and chromatographic peak retention time, as well as fragmentation regularity summarized from reference substance and the literature, we could effectively identify the chemical structure of the components under test...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28928658/anti-inflammatory-antinociceptive-and-antioxidant-activities-of-methanol-and-aqueous-extracts-of-anacyclus-pyrethrum-roots
#14
Houria Manouze, Otmane Bouchatta, A Chemseddoha Gadhi, Mohammed Bennis, Zahra Sokar, Saadia Ba-M'hamed
Anacyclus pyrethrum (L.) is a plant widely used in Moroccan traditional medicine to treat inflammatory and painful diseases. The objective of the present study was to evaluate the antinociceptive, anti-inflammatory and antioxidant activities of aqueous and methanol extracts of Anacyclus pyrethrum roots (AEAPR and MEAPR). The anti-inflammatory effect of AEAPR and MEAPR was determined in xylene-induced ear edema and Complete Freund's Adjuvant (CFA)-induced paw edema. The antinociceptive activity of AEAPR and MEAPR (125, 250, and 500 mg/kg) administered by gavage was examined in mice by using acetic acid-induced writhing, hot plate, and formalin tests, and the mechanical allodynia were assessed in CFA-induced paw edema...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28921579/material-basis-studies-of-anti-influenza-a-active-ingredients-in-tanreqing-injection
#15
Haiyan Zhu, Mingcang Chen, Xunlong Shi, Chenchen Shi, Chenggang Huang
Tanreqing Injection (TRQ) has been used primarily in treating infections of the upper respiratory tract and serious influenza in China, as a classical compound herbal recipe. TRQ had been demonstrated to have effects of clearing heat, eliminating phlegm, detoxification, reducing inflammation and alleviating cough. The survival rate, histopathology of lungs and viral titers in mice were evaluated in this study to verify the curative effect of TRQ. However, there is not enough information about the components...
September 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28919499/comparing-electrical-stimulation-with-and-without-ultrasound-guidance-for-phenol-neurolysis-to-the-musculocutaneous-nerve
#16
Mary E Matsumoto, Jessica Berry, Herbie Yung, Martha Matsumoto, Michael C Munin
BACKGROUND: Ultrasound guidance is increasingly being used for neurolytic procedures that have traditionally been done with electrical stimulation (e-stim) guidance alone. Ultrasound visualization with e-stim-guided neurolysis can potentially allow adjustments in injection protocols that will reduce the volume of neurolytic agent needed to achieve clinical improvement. OBJECTIVE: This study compared e-stim only to e-stim with ultrasound guidance in phenol neurolysis of the musculocutaneous nerve (MCN) for elbow flexor spasticity...
September 15, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28918324/simultaneous-determination-and-pharmacokinetic-study-of-twelve-bioactive-compounds-in-rat-plasma-after-intravenous-administration-of-xuebijing-injection-by-uhplc-q-orbitrap-hrms
#17
Lihua Zuo, Qiuyue Zhong, Zhenhui Wang, Zhi Sun, Lin Zhou, Zhuolun Li, Tanye Xu, Yingying Shi, Jinfa Tang, Shuzhang Du, Xiaojian Zhang
Xuebijing injection (XBJ) is a traditional Chinese herbal prescription widely used in the treatment of sepsis. Extensive studies revealed that the major bioactive constituents of XBJ injection, including phenolic acids, flavonoids, monoterpene glycosides, lactones and organic acids, play an important role in the treatment. In this study, a rapid, sensitive and accurate ultra high performance liquid chromatography - Q Exactive hybrid quadrupole - orbitrap high-resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS) method was developed for simultaneous determination of twelve bioactive compounds in rat plasma after intravenous administration of XBJ injection...
September 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28855941/evaluation-of-fibrinolytic-and-antioxidant-effects-of-allium-affine-hydroalcoholic-extract
#18
Masoud Sadeghi, Leila Safaeian, Mohammadreza Aghaye Ghazvini, Mojtaba Ramezani
Allium affine is a member of Amaryllidaceae family, which grows wildly in some western regions of Iran. Limited information is available about the pharmacological activities of this plant. The present study aimed to evaluate the fibrinolytic and antioxidant effects of hydroalcoholic extract of A. affine aerial parts. The in vitro antioxidant properties of the extract were evaluated by total phenolic content assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and ferric reducing antioxidant power (FRAP) assay...
August 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28836990/wound-healing-effect-of-euphorbia-hirta-linn-euphorbiaceae-in-alloxan-induced-diabetic-rats
#19
Riazul Haque Tuhin, Marium Begum, Sohanur Rahman, Rubaba Karim, Taslima Begum, Siraj Uddin Ahmed, Ronia Mostofa, Amir Hossain, Mohamed Abdel-Daim, Rayhana Begum
BACKGROUND: Euphorbia hirta linn., is a species of Euphorbiaceae family. They are known as asthma plant, barokhervi. The plant E. hirta is famous for its medicinal importance among the tribal population. It is a common practice to use the whole to heal wounds. Several pharmacological properties including antiseptic, anti-inflammatory, antidibetic, antispasmodic, antibacterial, antiviral, antifungal, anticonvulsant, nootropic, antifertility and aphrodisiac properties have already been reported for this plant...
August 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28812474/protective-effect-of-raisin-currant-against-spatial-memory-impairment-and-oxidative-stress-in-alzheimer-disease-model
#20
Mohammad Gol, Davoud Ghorbanian, Nabiollah Soltanpour, Jamshid Faraji, Mohsen Pourghasem
OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive pathological changes of the brain. A number of studies demonstrated compelling evidence of the importance of oxidative processes in AD pathogenesis. Raisin contains polyphenol, phenolic acid, and tannin compounds, which have antioxidant and anti-inflammatory properties. The present study was aimed to evaluate the protective effect of raisin on neurobehavioral and histological changes in rats with Alzheimer...
August 16, 2017: Nutritional Neuroscience
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