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Phenol injections

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https://www.readbyqxmd.com/read/28059912/phenol-injection-versus-excision-with-open-healing-in-pilonidal-disease-a-prospective-randomized-trial
#1
Ismail Calikoglu, Kamil Gulpinar, Derya Oztuna, Atilla Halil Elhan, Osman Dogru, Cihangir Akyol, Bulent Erkek, Mehmet Ayhan Kuzu
BACKGROUND: Minimally invasive procedures may be an alternative to surgical excisions for pilonidal disease. OBJECTIVE: The aim of the study was to compare phenol injection versus excision with open healing technique. DESIGN: This is a prospective randomized study (ACTRN12612000868886). SETTINGS: This study was conducted at the Ankara University and Ufuk University Departments of Surgery. PATIENTS: One hundred forty patients were randomly assigned to phenol injection (n = 70) or excision with open healing (n = 70)...
February 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28043811/honokiol-induces-proteasomal-degradation-of-aml1-eto-oncoprotein-via-increasing-ubiquitin-conjugase-ubch8-expression-in-leukemia
#2
Bin Zhou, Haiying Li, Chongyun Xing, Haige Ye, Jianhua Feng, Jianbo Wu, Zhongqiu Lu, Jing Fang, Shenmeng Gao
AML1-ETO is the most common oncoprotein leading to acute myeloid leukemia (AML), in which 5-year survival rate is only about 30%. However, currently there are no specific therapies for AML patients with AML1-ETO. Here, we report that AML1-ETO protein is rapidly degraded by Honokiol (HNK), a natural phenolic compound isolated from the plant Magnolia officinalis. HNK induced the degradation of AML1-ETO in a concentration- and time-dependent manner in leukemic cell lines and primary AML blasts with t(8;21) translocation...
December 30, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28034282/evaluation-of-antidiabetic-activity-of-carnosol-phenolic-diterpene-in-rosemary-in-streptozotocin-induced-diabetic-rats
#3
Tahere Farkhondeh, Saeed Samarghandian, Abasalt Borji
Carnosol (CS) is an ortho-diphenolic diterpene in rosemary with great antioxidant potential. This study was designed to investigate the hypolipidemic, anti-oxidant, and anti-diabetic activities of CS. In our experiment, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, three CS (1, 5, 10 mg/kg/day)-treated diabetic groups. On the first day of the study, the diabetic groups were given streptozotocin (STZ) in a single intraperitoneal (i.p.) injection at a dose of 60 mg/kg for induction of diabetes...
December 29, 2016: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28003341/chicoric-acid-supplementation-prevents-systemic-inflammation-induced-memory-impairment-and-amyloidogenesis-via-inhibition-of-nf-%C3%AE%C2%BAb
#4
Qian Liu, Yuwei Chen, Chun Shen, Yating Xiao, Yutang Wang, Zhigang Liu, Xuebo Liu
Chicoric acid (CA), a natural phenolic acid extracted from chicory and the echinacea (purple coneflower) plant (Echinacea purpurea), has been regarded as a nutraceutical that has powerful antioxidant and antiobesity activities. We investigated the inhibitory effects of CA on systemic inflammation-induced neuroinflammation, amyloidogenesis, and cognitive impairment. C57BL/6J mice were treated with 0.05% CA in the drinking water for 45 d. The mice were then treated by intraperitoneal injection of LPS (lipopolysaccharide)...
December 21, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27988851/outcomes-following-sclerotherapy-for-mucosal-rectal-prolapse-with-oily-phenol-injection-single-centre-review
#5
Rohini Sahay, Govind Murthi, Richard Lindley
AIM OF THE STUDY: To review the outcomes of injection sclerotherapy with oily phenol for mucosal rectal prolapse. METHODS: Retrospective case note review of all children who underwent sclerotherapy with oily phenol injection as primary surgical intervention for mucosal rectal prolapse, from January 2007 to December 2015. MAIN RESULTS: A total of 31 patients were identified. Mean age at presentation was 4.8 years (range 5 months-12 years)...
December 17, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27965009/dual-reductive-oxidative-electrochemistry-liquid-chromatography-mass-spectrometry-towards-peptide-and-protein-modification-separation-and-identification
#6
Lars Büter, Lisa M Frensemeier, Martin Vogel, Uwe Karst
A new hyphenated technique based on on-line dual (oxidative and reductive) electrochemistry coupled to liquid chromatography and high resolution electrospray mass spectrometry is presented. Two liquid streams are combined, with one containing a disulfide, which is reduced to the respective thiol in an electrochemical cell based on a titanium working electrode. The other stream contains phenol, which is electrochemically activated to benzoquinone on a boron-doped diamond working electrode. Upon combination of the two streams, a Michael addition takes places, leading to the covalent coupling of thiol to quinone...
January 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27951473/oleuropein-aglycone-enhances-ucp1-expression-in-brown-adipose-tissue-in-high-fat-diet-induced-obese-rats-by-activating-%C3%AE-adrenergic-signaling
#7
Yuriko Oi-Kano, Yusaku Iwasaki, Toshiyuki Nakamura, Tatsuo Watanabe, Tsuyoshi Goto, Teruo Kawada, Kenichi Watanabe, Kazuo Iwai
Oleuropein is the pungent principle of raw olives. Oleuropein aglycone (OA) is a major phenolic compound in extra virgin olive oil and the absorbed form of oleuropein. We aimed to determine the mechanism underlying the nutritional effects of oleuropein and OA on interscapular brown adipose tissue (IBAT) in rats with high-fat (HF) diet-induced obesity by examining the agonistic activity of oleuropein and OA toward the transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1). Four-week-old male Sprague-Dawley rats were fed an HF (palm oil 30% wt:wt) diet alone or with oleuropein (HF-O, 1 g/kg diet) for 28 days...
November 23, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27941199/-peripheral-nerves-phenolisation-in-spasticity-management-forgotten-art-or-interesting-perspective
#8
Jerzy Kiwerski, Karolina Turżańska, Ryszard Pluta, Małgorzata Drelich, Aneta Zarębska, Mirosław Jabłoński
INTRODUCTION: Spasticity is one of the most common obstacles in the process of rehabilitation after permanent central nervous system injury. Statistics show that the problem affects more than 12 billion people all over the world. Treatment of spasticity is necessary for proper rehabilitation, prevention of secondary disability, pain management and also strongly influences quality of life. Nowadays the most common formula used for the treatment of local spasticity is injection of botulinum toxin...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27937124/antioxidant-anti-inflammatory-and-anti-septic-potential-of-phenolic-acids-and-flavonoid-fractions-isolated-from-lolium-multiflorum
#9
Ki-Choon Choi, Young-Ok Son, Jung-Min Hwang, Beom-Tae Kim, Minseon Chae, Jeong-Chae Lee
CONTEXT: Interest has recently renewed in using Lolium multiflorum Lam. (Poaceae) (called Italian ryegrass; IRG) silage as an antioxidant and anti-inflammatory diet. OBJECTIVE: This study investigated the antioxidant, anti-inflammatory and anti-septic potential of IRG silage and identified the primary components in IRG active fractions. MATERIALS AND METHODS: Total 16 fractions were separated from the chloroform-soluble extract of IRG aerial part using Sephadex LH-20 column before HPLC analysis...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27920825/evaluation-of-cardioprotective-effect-of-aqueous-extract-of-allium-cepa-linn-bulb-on-isoprenaline-induced-myocardial-injury-in-wistar-albino-rats
#10
Geeta B Kharadi, Kaksha J Patel, Bhargav M Purohit, Seema N Baxi, C B Tripathi
To investigate the cardioprotective potential of the aqueous extract of Allium cepa Linn. bulb in isoprenaline-induced myocardial injury in Wistar albino rats. In vitro total phenolic, total flavonoid content and 2, 2'-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. Isoprenaline-induced myocardial injury model was used to evaluate in vivo effect of aqueous extract of A. cepa in Wistar albino rats. Seventy two rats were randomly divided in 6 groups. Rats were treated with A. cepa 400 mg/kg and 800 mg/kg doses for 30 days and myocardial injury was produced by subcutaneous injection of isoprenaline (ISO) 85 mg/kg on day 28 and 29...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27902771/piceatannol-attenuates-renal-fibrosis-induced-by-unilateral-ureteral-obstruction-via-downregulation-of-histone-deacetylase-4-5-or-p38-mapk-signaling
#11
Sin Young Choi, Zhe Hao Piao, Li Jin, Jung Ha Kim, Gwi Ran Kim, Yuhee Ryu, Ming Quan Lin, Hyung-Seok Kim, Hae Jin Kee, Myung Ho Jeong
Piceatannol, a resveratrol metabolite, is a phenolic compound found in red wine and grapes. We investigated the effect of piceatannol on renal fibrosis and histone deacetylase (HDAC) expression in a mouse model of unilateral ureteral obstruction (UUO). Fibrosis was established by UUO and piceatannol was intraperitoneally injected for 2 weeks. Piceatannol suppressed extracellular matrix (ECM) protein deposition including collagen type I and fibronectin as well as connective tissue growth factor (CTGF) and α-smooth muscle actin (α-SMA) in UUO kidneys...
2016: PloS One
https://www.readbyqxmd.com/read/27875788/simultaneous-determination-and-pharmacokinetic-study-of-four-phenolic-acids-in-rat-plasma-using-uflc-ms-ms-after-intravenous-administration-of-salvianolic-acid-for-injection
#12
Xiuman Xie, Jingzhuo Miao, Wanyang Sun, Jingyi Huang, Dongxiang Li, Shuming Li, Ling Tong, Guoxiang Sun
A simple, sensitive and selective ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was established for simultaneous determination and pharmacokinetic study of rosmarinic acid (RA), salvianolic acid D (Sal D), lithospermic acid (LA) and salvianolic acid B (Sal B) in rat plasma after intravenous administration of salvianolic acid for injection (SAFI). Three doses of administration, containing 14, 28 and 56mg/kg, were investigated in this study. Plasma samples were pretreated using protein precipitation (PP) with pre-cooled acetonitrile...
February 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27860258/sesamol-supplementation-prevents-systemic-inflammation-induced-memory-impairment-and-amyloidogenesis-via-inhibition-of-nuclear-factor-kappab
#13
Zhigang Liu, Yuwei Chen, Qinglian Qiao, Yali Sun, Qian Liu, Bo Ren, Xuebo Liu
SCOPE: The aim of the present study was to investigate the inhibitory effects of sesamol, a phenolic lignan from sesame, on the systemic inflammation-induced neuroinflammation and amyloidogenesis as well as memory impairment. METHODS AND RESULTS: C57BL/6J mice were treated with 0.05% sesamol (w/v) in the drinking water for 7 weeks, and then the mice were treated by intraperitoneal injection of LPS (0.25 mg/kg) for 9 days. Sesamol supplementation significantly improved (by 36...
November 15, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27859496/application-of-a-solvent-free-solid-injection-technique-coupled-with-gc-ms-for-discrimination-between-the-secondary-metabolites-of-wild-and-cultivated-south-korean-medicinal-foods
#14
Lieu T B Truong, A M Abd El-Aty, Hyun Jin Kim, Md Musfiqur Rahman, Sung-Woo Kim, Ho-Chul Shin, Jae-Han Shim
Solvent-free solid injection was applied to differentiate between wild and cultivated South Korean medicinal foods, including dureup (Aralia elata), deodeok (Codonopsis lanceolata) and doraji (Platycodon grandiflorus). A number of compounds were identified in wild and cultivated dureup (53 and 46), deodeok (47 and 51) and doraji (43 and 38). Secondary metabolites, including butanal,2-methyl-, β-caryophyllene, neoclovene, α-humulene, γ-curcumene, β-bisabolene, and phytol, were identified in dureup with significantly (P < 0...
November 15, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27810529/integrated-processes-for-produced-water-polishing-enhanced-flotation-sedimentation-combined-with-advanced-oxidation-processes
#15
Silvia Jiménez, María M Micó, Marina Arnaldos, Enrique Ferrero, Jorge J Malfeito, Francisco Medina, Sandra Contreras
In this study, bench scale dissolved air flotation (DAF) and settling processes have been studied and compared to a novel flotation technology based on the use of glass microspheres of limited buoyancy and its combination with conventional DAF, (Enhanced DAF or E-DAF). They were evaluated as pretreatments for advanced oxidation processes (AOPs) to polish produced water (PW) for reuse purposes. Settling and E-DAF without air injection showed adequate turbidity and oil and grease (O&G) removals, with eliminations higher than 87% and 90% respectively, employing 70 mg L(-1) of FeCl3 and 83 min of settling time, and 57...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27809597/phytochemical-screening-by-lc-ms-and-lc-pda-of-ethanolic-extracts-from-the-fruits-of-kigelia-africana-lam-benth
#16
Rosaria Costa, Ambrogina Albergamo, Vito Pellizzeri, Giacomo Dugo
Kigelia africana is a tree native to Africa, with a local employment in numerous fields, ranging from traditional medicine to cosmetics and religious rituals. Parts of the plant generally used are stem bark, fruits, roots and leaves. The fruits, which have a singular 'sausage' shape, are widely exploited by local folk, in particular for applications/products involving genito-urinary apparatus of both human genders. The scope of this work was to make a consistent chemical investigation on this plant species, in order to clarify and increase the information at present available in literature...
November 4, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27780138/malva-sylvestris-extract-protects-upon-lithium-carbonate-induced-kidney-damages-in-male-rat
#17
Anouar Ben Saad, Ilhem Rjeibi, Dalel Brahmi, Amani Smida, Sana Ncib, Nacim Zouari, Lazher Zourgui
Malva sylvestris has recently attracted special attention due to its potential activities in many chronic disorders. We aimed to assess the beneficial effects of Malva sylvestris extract against lithium carbonate induced renal damage in male Wistar rats. For this purpose, Malva sylvestris extract at a dose of 0.2g/kg was orally administrated, followed by 25mg/kg of lithium carbonate (intraperitoneal injection) for 30 days. Malva sylvestris extract was proved to contain large amounts of K(+), Na(+), Ca(++) and the existence of phenolic acids and flavonoids shown by the obtained HPLC-based analysis...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27778760/effect-of-flavonoids-rich-extract-of-capparis-spinosa-on-inflammatory-involved-genes-in-amyloid-beta-peptide-injected-rat-model-of-alzheimer-s-disease
#18
Nazanin Mohebali, Seyed Abolhassan Shahzadeh Fazeli, Hossein Ghafoori, Zeinab Farahmand, Elham MohammadKhani, Faezeh Vakhshiteh, Abdolreza Ghamarian, Mansoureh Farhangniya, Mohammad Hossein Sanati
OBJECTIVES: Alzheimer's disease (AD) is one of the most common forms of neurodegenerative diseases. Despite vast ongoing researches focusing on the area, little is known about novel treatments. In this study, we aimed to survey the effects of Capparis spinosa (C. spinosa) extract on amyloid-beta peptide (Aβ)-injected rat. METHODS: For this purpose, hydroalcoholic extracts of caper leaf and fruit were prepared. Total phenolic content, DPPH, and FRAP assay were accomplished to determine antioxidant activity of C...
October 25, 2016: Nutritional Neuroscience
https://www.readbyqxmd.com/read/27752504/the-effects-of-co2-injection-and-barrel-temperatures-on-the-physiochemical-and-antioxidant-properties-of-extruded-cereals
#19
Thazin Thin, Lin Myat, Gi-Hyung Ryu
The effects of CO2 injection and barrel temperatures on the physiochemical and antioxidant properties of extruded cereals (sorghum, barley, oats, and millet) were studied. Extrusion was carried out using a twin-screw extruder at different barrel temperatures (80, 110, and 140°C), CO2 injection (0 and 500 mL/min), screw speed of 200 rpm, and moisture content of 25%. Extrusion significantly increased the total flavonoid content (TFC) of extruded oats, and β-glucan and protein digestibility (PD) of extruded barley and oats...
September 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/27742410/baicalein-attenuates-%C3%AE-synuclein-aggregation-inflammasome-activation-and-autophagy-in-the-mpp-treated-nigrostriatal-dopaminergic-system-in-vivo
#20
Kai-Chih Hung, Hui-Ju Huang, Yi-Ting Wang, Anya Maan-Yuh Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Neuroinflammation, oxidative stress, and protein aggregation form a vicious cycle in the pathophysiology of Parkinson's disease (PD); activated microglia is the main location of neuroinflammation. A Chinese medicine book, "Shanghan Lun", known as the "Treatises on Cold damage Diseases" has suggested that Scutellaria baicalensis Georgi is effective in treating CNS diseases. The anti-inflammatory mechanisms of baicalein, a phenolic flavonoid in the dried root of Scutellaria baicalensis Georgi, remain to be explored...
December 24, 2016: Journal of Ethnopharmacology
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