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Phenol injections

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https://www.readbyqxmd.com/read/29336521/identification-and-quantification-of-vocs-by-proton-transfer-reaction-time-of-flight-mass-spectrometry-an-experimental-workflow-for-the-optimization-of-specificity-sensitivity-and-accuracy
#1
Andrea Romano, George B Hanna
Proton Transfer Reaction Time of Flight Mass Spectrometry (PTR-ToF-MS) is a direct injection MS technique, allowing for the sensitive and real-time detection, identification and quantification of volatile organic compounds (VOCs). When aiming to employ PTR-ToF-MS for targeted VOC analysis some methodological questions must be addressed, such as the need to correctly identify product ions, or evaluating the quantitation accuracy. This work proposes a workflow for PTR-ToF-MS method development, addressing the main issues affecting the reliable identification and quantification of target compounds...
January 16, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29334186/natural-humic-acid-based-phototheranostic-agent
#2
Zhao-Hua Miao, Kai Li, Pei-Ying Liu, Zhenglin Li, Huanjie Yang, Qingliang Zhao, Manli Chang, Qingzhu Yang, Liang Zhen, Cheng-Yan Xu
Humic acids, a major constituent of natural organic carbon resources, are naturally formed through the microbial biodegradation of animal and plant residues. Due to numerous physiologically active groups (phenol, carboxyl, and quinone), the biomedical applications of humic acid have been already investigated across different cultures for several centuries or even longer. In this work, sodium humate, the sodium salt of humic acid, is explored as phototheranostic agent for light-induced photoacoustic imaging and photothermal therapy based on intrinsic absorption in the near-infrared region...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29318852/-effects-of-electroacupuncture-on-ultrastructure-of-interstitial-cells-of-cajal-and-stem-cell-factor-kit-signal-pathway-of-gastric-antrum-in-diabetic-gastroparesis-rats
#3
Cheng-Cheng Zhang, Ya-Ping Lin, Yan Peng, Zeng-Hui Yue, Hai-Jiao Chen, Jian-Wen Yang, Wei-Wei Liu, Li Liu
OBJECTIVE: To observe the effects of electroacupuncture (EA) on gastrointestinal motility and the ultrastructure of interstitial cells of Cajal (ICC) and the expressions of c-kit receptor protein and stem cell factor (SCF) mRNA in diabetic gastroparesis (DGP) rats, so as to explore its mechanism. METHODS: Fifty SD rats were randomly divided into normal, model, acupoint, non-acupoint and metoclopramide groups (n=10 rats/group). DGP model was established by intraperitoneal injection of streptozotocin (STZ, 2%), and raised with high-sugar high-fat diet irregularly...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29316696/protective-effects-of-protocatechuic-acid-on-seizure-induced-neuronal-death
#4
Song Hee Lee, Bo Young Choi, A Ra Kho, Jeong Hyun Jeong, Dae Ki Hong, Sang Hwon Lee, Sang Yup Lee, Min Woo Lee, Hong Ki Song, Hui Chul Choi, Sang Won Suh
Protocatechuic acid (PCA) is a type of phenolic acid found in green tea and has been shown to have potent antioxidant and anti-inflammatory properties. However, the effect of PCA on pilocarpine seizure-induced neuronal death in the hippocampus has not been evaluated. In the present study, we investigated the potential therapeutic effects of PCA on seizure-induced brain injury. Epileptic seizure was induced by intraperitoneal (i.p.) injection of pilocarpine (25 mg/kg) in adult male rats, and PCA (30 mg/kg) was injected into the intraperitoneal space for three consecutive days after the seizure...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29311400/hypericum-humifusum-leaves-attenuates-hepatic-ischemia-reperfusion-injury-in-a-rat-model
#5
Henda Ferchichi, Issam Salouage, Sarra Bacha, Nadia Kourda, Nadia Jebabli, Emna Gaies, Anis Klouz, Sameh Trabelsi
INTRODUCTION: Effective prevention strategies require specific actions during the different phases of ischemia-reperfusion (I-R) injury. The objective of our study is to evaluate the effect of aqueous extract of Hypericum humifusum leaves (HHL) on liver I-R model in Rat. MATERIAL AND METHODS: Animals were subjected to 90 min of hepatic ischemia followed by reperfusion (120 min). HHL extract (25 mg/mL/kg) was injected 15 min before reperfusion. To evaluate the effect of HHL extract on I-R, we have monitored transaminases levels, Malondialdehyde (MDA) concentration, histological lesions (apoptosis and necrosis) and compared the results to a reference oxidant vitamin E...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29301240/the-determination-of-blood-glucose-lowering-and-metabolic-effects-of-mespilus-germanica-l-hydroacetonic-extract-on-streptozocin-induced-diabetic-balb-c-mice
#6
Fatemeh Shafiee, Elnaz Khoshvishkaie, Ali Davoodi, Ayat Dashti Kalantar, Hossein Bakhshi Jouybari, Ramin Ataee
Background: The serum glucose lowering, normalization animal body weight, and antioxidative stress effects of Mespilus germanica L. leaf extract were investigated in normal and streptozotocin-induced Balb/C mice. Methods: The phenol and flavonoid of the leaves of M. germanica were extracted by percolation and concentrated using a rotary evaporator. Its total phenol and flavonoid content was determined using folin and aluminum chloride methods, respectively. The study was conducted on 48 matured male Balb/C mice (20-30 g) divided into 6 groups (n = 8)...
January 1, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29208914/chemical-profiling-and-quantification-of-xuebijing-injection-a-systematic-quality-control-strategy-using-uhplc-q-exactive-hybrid-quadrupole-orbitrap-high-resolution-mass-spectrometry
#7
Zhi Sun, Lihua Zuo, Tongwen Sun, Jinfa Tang, Daling Ding, Lin Zhou, Jian Kang, Xiaojian Zhang
To clarify and quantify the chemical profiling of XueBiJing injection (XBJ) rapidly, a feasible and accurate strategy was developed by applying ultra high performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS). A total of 162 components were characterized, including 19 phenanthrenequinones, 33 lactones, 28 flavonoids and 12 phenolic acids and 51 other compounds. Among them, 38 major compounds were unambiguously quantified by comparing with reference standards...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29199574/immunoreactivity-of-the-cold-water-extract-of-royal-sun-culinary-medicinal-mushroom-agaricus-brasiliensis-strain-ka21-agaricomycetes-assessed-by-immunoglobulin-preparations-for-intravenous-injection
#8
Katsuya Tajima, Masuro Motoi, Akitomo Motoi, Daisuke Yamanaka, Ken-Ichi Ishibashi, Yoshiyuki Adachi, Naohito Ohno
The royal sun medicinal mushroom, Agaricus brasiliensis, is a health food material that helps to improve quality of life. A. brasiliensis has long been used as a tea by extraction with cold and hot water. Our group has been investigating the immunopharmacological activities of the A. brasiliensis KA21 strain, which is cultivated outdoors. We prepared cold water (AgCWE) and hot water (AgHWE) extracts of this strain. AgCWE contained a larger proportion of proteins, including enzymes, and showed a brownish color during the extraction process...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29196052/ferulic-acid-loaded-nanostructured-lipid-carriers-a-promising-nanoformulation-against-the-ischemic-neural-injuries
#9
Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand
AIMS: Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, ferulic acid (FA), has shown promising antioxidant and neuroprotective effects, however, low bioavailability may negatively affect its efficiency. This, prompted us to incorporate FA into the nanostructured lipid carriers (FA-NLCs) and evaluate its therapeutic potential in in vitro and in vivo models of ischemic stroke. MAIN METHODS: FA-NLCs were prepared by high-pressure homogenization followed by physicochemical characterization, evaluation of the bioactivity of FA-NLCs in oxygen-glucose deprivation (OGD) and global cerebral ischemia/reperfusion (I/R) injury and implication of phosphatidylinositol 3-kinase (PI3K) pathway in this regard...
November 28, 2017: Life Sciences
https://www.readbyqxmd.com/read/29192447/-huvecs-extraction-and-uhplc-ltq-orbitrap-analysis-for-screening-vascular-endothelium-protective-components-in-kudiezi-injection
#10
Si-Yi Liu, Hong-Zhu Zhang, Jing Fan, Zhan-Peng Shang, Fei Wang, Wei-Jie Li, Ying Liu, Jian-Qiu Lu, Jia-Yu Zhang
An effective method has been employed as a tool for screening active components in Kudiezi injection by using cell chromatography and sensitive UHPLC-HR-MSn method. The potential bioactive components in Kudiezi injection could be selectively bound to the HUVECs target cells first. After cell target desensitization and inactivation, the chemical constituents with cell target affinity were identified by LC-MS, so as to screen the possible active components in Kudiezi injection. Based on the accurate mass measurements and the retention time, in total, 9 compounds were tentatively identified and characterized, including 4 sesquiterpene lactones, 3 phenolic acids and 2 flavonoids...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29142429/antioxidant-and-hepatoprotective-potential-of-swaras-and-hima-extracts-of-tinospora-cordifolia-and-boerhavia-diffusa-in-swiss-albino-mice
#11
Amit Kaushik, Athar Husain, Harshika Awasthi, Dewasya Pratap Singh, Raziuddin Khan, Dayanandan Mani
Background: In Ayurveda, five basic extraction procedures are mentioned in order of their decreasing potency. Swaras is considered as the most potent followed by, kalka, kwatha, fanta and hima. Objective: Present study was carried out to investigate the antioxidant and hepatoprotective potential of swaras and hima extracts of T.cordifolia and B. diffusa. Materials and Methods: Swaras and hima extracts of T. cordifolia and B. diffusa were prepared...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29131698/the-anti-inflammatory-and-antioxidant-effects-of-salvia-officinalis-on-lipopolysaccharide-induced-inflammation-in-rats
#12
Umut Kerem Kolac, Mehmet Cengiz Ustuner, Neslihan Tekin, Derya Ustuner, Emine Colak, Emre Entok
Salvia officinalis, which has a high phenolic acid and flavonoid content, is a powerful antioxidant and anti-inflammatory herb. Inflammation plays an important role in the pathophysiology of many diseases and could cause damage by means of oxidative stress. The aim of this study was to investigate the anti-inflammatory and antioxidant activity of S. officinalis formed lipopolysaccharide (LPS)-induced experimental inflammation model. Four- to five-month-old 42 female Wistar albino rats were divided into six groups...
November 13, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29111651/a-series-of-lithium-pyridyl-phenolate-complexes-with-a-pendant-pyridyl-group-for-electron-injection-layers-in-organic-light-emitting-devices
#13
Satoru Ohisa, Taichiro Karasawa, Yuichiro Watanabe, Tatsuya Ohsawa, Yong-Jin Pu, Tomoyuki Koganezawa, Hisahiro Sasabe, Junji Kido
We report a new series of lithium pyridyl phenolate complexes with a pendant pyridyl group, Li2BPP, Li3BPP, and Li4BPP, in which the pendant pyridines are substituted at the 2-, 3-, and 4-positions, respectively. The most important difference between these complexes is their molecular planarity; Li3BPP and Li4BPP adopt twisted bipyridine structures, whereas Li2BPP adopts a planar structure owing to the steric hindrance and chelating effect of bipyridine on the Li core. The planar structure leads to crystallization through π-π stacking interactions, and the small differences in the molecular structures of the pendant pyridine rings cause drastic differences in the physical properties of thin solid films of these complexes...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29105854/simultaneous-determination-and-tissue-distribution-studies-of-four-phenolic-acids-in-rat-tissue-by-uflc-ms-ms-after-intravenous-administration-of-salvianolic-acid-for-injection
#14
Shuang Li, Xiuman Xie, Dongxiang Li, Zhiguo Yu, Ling Tong, Yunli Zhao
A rapid, simple and sensitive ultra-fast liquid chromatography tandem mass spectrometric method was developed and validated for simultaneous determination and tissue distribution studies of rosmarinic acid, salvianolic acid D, lithospermic acid and salvianolic acid B in rats after intravenous administration of salvianolic acid for injection. The tissue homogenate samples were pretreated by protein precipitation with pre-cooled acetonitrile. Chromatographic separation was achieved on a Waters Cortecs UPLC C18 column (1...
November 6, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29105737/enhanced-tissue-adhesiveness-of-injectable-gelatin-hydrogels-through-dual-catalytic-activity-of-horseradish-peroxidase
#15
Thai Thanh Hoang Thi, Yunki Lee, Seung Bae Ryu, Dai Hai Nguyen, Ki Dong Park
Development of bioadhesives with tunable mechanical strength, high adhesiveness, biocompatibility, and injectability is greatly desirable in all surgeries to replace or complement the sutures and staples. Herein, the dual catalytic activity of horseradish peroxidase is exploited to in situ form the hydroxyphenyl propionic acid-gelatin/thiolated gelatin (GH/GS) adhesive hydrogels including two alternative crosslinks (phenol-phenol and disulfide bonds) with fast gelation (few seconds - several minutes) and improved physicochemical properties...
November 6, 2017: Biopolymers
https://www.readbyqxmd.com/read/29098952/a-combination-of-absorption-and-enzymatic-biodegradation-phenol-elimination-from-aqueous-and-organic-phase
#16
Tandjaoui Nassima, Abouseoud Mahmoud, Couvert Annabelle, Amrane Abdeltif, Tassist Amina
Peroxidase from Brassica rapa (BRP) was immobilized as cross-linked enzyme aggregates (CLEAs) and used to treat air containing phenol as a model molecule of volatile organic compounds (VOCs). Prior to enzymatic treatment, phenol was absorbed into aqueous or organic phase (silicone oil, Rhodorsil® 47V20) to reach concentrations ranging from 20 to 160mg/L. The process of enzymatic degradation was carried out by introducing a desired weighing of BRP-CLEAs into preparations and reaction was started by injecting H2O2 solution to medium...
November 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29097839/ethanol-extracts-collected-from-the-styela-clava-tunic-alleviate-hepatic-injury-induced-by-carbon-tetrachloride-ccl4-through-inhibition-of-hepatic-apoptosis-inflammation-and-fibrosis
#17
Eun Kyoung Koh, Ji Eun Kim, Sung Hwa Song, Ji Eun Sung, Hyun Ah Lee, Kil Soo Kim, Jin Tae Hong, Dae Youn Hwang
The Styela clava tunic (SCT) is known as a good raw material for preparing anti-inflammatory compounds, wound healing films, guided bone regeneration, and food additives. To investigate whether ethanol extracts of the SCT (EtSCT) could protect against hepatic injury induced by carbon tetrachloride (CCl4) in ICR mice, alterations in serum biochemical indicators, histopathology, hepatic apoptosis, inflammation, and fibrosis were observed in ICR mice pretreated with EtSCT for 5 days before CCl4 injection. EtSCT contained 15...
October 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29052379/-simultaneous-determination-of-ten-major-compounds-including-iridoid-glycosides-and-phenolic-acids-in-pterocephalus-hookeri-by-uplc-pda
#18
Ce Tang, Jian Wen, Jing Wang, Ke-Hui Zhao, Gang Fan, Xian-Li Meng, Zhong-Mei Zou, Yi Zhang
This study is to develop an UPLC-PDA method for determination of 10 major components in Pterocephalus. The UPLC-PDA assay was performed on a Waters Acquity UPLCR BEH C₁₈(2.1 mm ×100 mm,1.7 μm), and the column temperature was at 30 ℃. The mobile phase consists of water containing 0.2% phosphoric acid (A) and acetonitrile (B) in gradient elution at a flow rate of 0.4 mL•min⁻¹. The detection wave length was set at 237 and 325 nm, and the injection volume was 1 μL in the UPLC system. The linear range of 10 detected compounds were good (r≥0...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29052076/-e-2-methoxy-4-3-4-methoxyphenyl-prop-1-en-1-yl-phenol-ameliorates-lps-mediated-memory-impairment-by-inhibition-of-stat3-pathway
#19
Ji Yeon Choi, Chul Ju Hwang, Do Yeon Lee, Sun Mi Gu, Hee Pom Lee, Dong Young Choi, Ki Wan Oh, Sang-Bae Han, Jin Tae Hong
Alzheimer's disease (AD) is pathologically characterized by an excessive accumulation of amyloid-beta (Aβ) fibrils within the brain. We tested the anti-inflammatory and anti-amyloidogenic effects of (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor. We examined whether MMPP (5 mg/kg in drinking water for 1 month) prevents amyloidogenesis and cognitive impairment on AD model mice induced by intraperitoneal LPS (250 μg/kg daily 7 times) injections...
December 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28993279/anti-scorpion-venom-activity-of-thapsia-garganica-methanolic-extract-histopathological-and-biochemical-evidences
#20
Btissam Bouimeja, Moulay Abdelmonaim El Hidan, Oulaid Touloun, Mehdi Ait Laaradia, Loubna Ait Dra, Noureddine El Khoudri, Abderrahman Chait, Ali Boumezzough
ETHNOPHARMACOLOGICAL RELEVANCE: Thapsia garganica, is a herbal medicine traditionally used as diuretic, emetic and purgative. It is also used as anti-scorpion venom in Morocco; however, its protective effects against scorpion venom remain elusive. AIM OF THE STUDY: The present study was undertaken to evaluate anti-venom activity of T. garganica in vivo through histological and biochemical studies. MATERIALS AND METHODS: Methanolic leaves extract of T...
October 6, 2017: Journal of Ethnopharmacology
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