keyword
MENU ▼
Read by QxMD icon Read
search

Phenol injections

keyword
https://www.readbyqxmd.com/read/28437805/anti-inflammatory-antipyretic-and-antinociceptive-effects-of-a-cressa-cretica-aqueous-extract
#1
Heba Mohammed Ibrahim Abdallah, Abdelsamed Ibrahim Elshamy, Abd El-Nasser Gaber El Gendy, Ahmed Mohamed Abd El-Gawad, Elsayed Abouelfotowh Omer, Marinella De Leo, Luisa Pistelli
Cressa cretica is a widely grown halophytic plant traditionally used for the treatment of different ailments. Previous investigations reported its biological activity on a wide spectrum of diseases. In this study, in vivo antinociceptive, anti-inflammatory, and antipyretic activities of C. cretica aqueous extract whole plant were evaluated. In addition, the total polyphenol content, the total flavonoid content, and the chemical characterization of the extract were performed. C. cretica showed writhing inhibition in acetic acid-induced peripheral nociception of 43 and 48 % at doses of 50 and 100 mg/kg, respectively...
April 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28410190/dietary-oleuropein-inhibits-tumor-angiogenesis-and-lymphangiogenesis-in-the-b16f10-melanoma-allograft-model-a-mechanism-for-the-suppression-of-high-fat-diet-induced-solid-tumor-growth-and-lymph-node-metastasis
#2
Hyerim Song, Do Young Lim, Jae In Jung, Han Jin Cho, So Young Park, Gyoo Taik Kwon, Young-Hee Kang, Ki Won Lee, Myung-Sook Choi, Jung Han Yoon Park
Previously, we reported that high-fat-diet (HFD)-induced obesity stimulates melanoma progression in the B16F10 allograft model. In this study, we examined whether oleuropein (OL), the most abundant phenolic compound in olives, inhibits HFD-induced melanoma progression. Four-week-old male C57BL/6N mice were fed a HFD-diet with or without OL. After 16 weeks of feeding, B16F10-luc cells were subcutaneously injected and the primary tumor was resected 3 weeks later. OL suppressed HFD-induced solid tumor growth. In the tumor tissues, OL reduced HFD-induced expression of angiogenesis (CD31, VE-cadherin, VEGF-A, and VEGFR2), lymphangiogenesis (LYVE-1, VEGF-C, VEGF-D, and VEGFR3), and hypoxia (HIF-1α and GLUT-1) markers as well as HFD-induced increases in lipid vacuoles and M2 macrophages (MΦs)...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28383201/polyphenol-inspired-facile-construction-of-smart-assemblies-for-atp-and-ph-responsive-tumor-mr-optical-imaging-and-photothermal-therapy
#3
Xiao-Rong Song, Shi-Hua Li, Jiayong Dai, Liang Song, Guoming Huang, Ruhui Lin, Juan Li, Gang Liu, Huang-Hao Yang
Smart assemblies have attracted increased interest in various areas, especially in developing novel stimuli-responsive theranostics. Herein, commercially available, natural tannic acid (TA) and iron oxide nanoparticles (Fe3 O4 NPs) are utilized as models to construct smart magnetic assemblies based on polyphenol-inspired NPs-phenolic self-assembly between NPs and TA. Interestingly, the magnetic assemblies can be specially disassembled by adenosine triphosphate, which shows a stronger affinity to Fe3 O4 NPs than that of TA and partly replaces the surface coordinated TA...
April 6, 2017: Small
https://www.readbyqxmd.com/read/28381798/gallic-acid-and-dodecyl-gallate-prevents-carbon-tetrachloride-induced-acute-and-chronic-hepatotoxicity-by-enhancing-hepatic-antioxidant-status-and-increasing-p53-expression
#4
Marlene Raimunda Andreola Perazzoli, Camila Katerin Perondi, Cesar Milton Baratto, Evelyn Winter, Tânia Beatriz Creczynski-Pasa, Claudriana Locatelli
Gallic acid (3,4,5-trihydroxybenzoic acid, GA), a natural phenolic acid has been reported as a strong antioxidant. Therefore the present study was designed to evaluate the effects of GA and dodecyl gallate (DGA) against acute and chronic carbon tetrachloride (CCl4)-induced hepatotoxicity. For acute model, rats were orally treated with GA and DGA for 7 d prior to CCl4 by intraperitoneally (i.p.) injection. For the chronic model, rats were orally treated with GA or DGA and CCl4 i.p. twice a week for four weeks...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28378280/efficacy-of-phenyl-quinoline-phenol-derivatives-as-cox-2-inhibitors-an-approach-to-emergent-the-small-molecules-as-the-anti-inflammatory-and-analgesic-therapeutics
#5
A Manikandan, S Ravichandran, K I Sathiyanarayanan, A Sivakumar
2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequently, to get more insight into the binding mode with COX-2, compounds 4a-l were docked into the COX-2 (PDB ID: 1CX2) active site. In the Human Red Blood Cells (HRBC) membrane stabilization assay (in vitro anti-inflammatory), compounds 4f (IC50 0...
April 4, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28363525/protective-effect-of-a-phenolic-extract-containing-indoline-amides-from-portulaca-oleracea-against-cognitive-impairment-in-senescent-mice-induced-by-large-dose-of-d-galactose-nano2
#6
Peipei Wang, Hongxiang Sun, Dianyu Liu, Zezhao Jiao, Su Yue, Xiuquan He, Wen Xia, Jianbo Ji, Lan Xiang
ETHNOPHARMACOLOGICAL RELEVANCE: Portulaca oleracea L. is a potherb and also a widely used traditional Chinese medicine. In accordance with its nickname "longevity vegetable", pharmacological study demonstrated that this plant possessed antioxidant, anti-aging, and cognition-improvement function. Active principles pertaining to these functions of P. oleracea need to be elucidated. AIM OF THE STUDY: The present study evaluated the effect of a phenolic extract (PAAs) from P...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28350656/an-update-on-the-anatomy-of-the-forehead-compartments
#7
Sebastian Cotofana, Asima Mian, Jonathan M Sykes, Wolfgang Redka-Swoboda, Andrea Ladinger, Tatjana Pavicic, Thilo L Schenck, Fahd Benslimane, Fabio Ingallina, Alexander Schlattau
BACKGROUND: The forehead is one of the most frequent locations for neuromodulator and soft tissue filler applications; however, the underlying anatomy is still poorly understood. Thus far, the presence of deep forehead compartments has not been confirmed. METHODS: Twenty Caucasian cephalic specimens, 15 fresh frozen (six female and nine male) and five with formalin-phenol embalmment (three female and two male) were investigated using contrast-enhanced computed tomographic scans, dye injections, and anatomical dissections...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28348600/delivery-of-bone-marrow-derived-mesenchymal-stem-cells-improves-tear-production-in-a-mouse-model-of-sj%C3%A3-gren-s-syndrome
#8
Hema S Aluri, Mahta Samizadeh, Maria C Edman, Dillon R Hawley, Helene L Armaos, Srikanth R Janga, Zhen Meng, Victor G Sendra, Pedram Hamrah, Claire L Kublin, Sarah F Hamm-Alvarez, Driss Zoukhri
The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of sterile phosphate buffered saline (PBS, control) or murine BD-MSCs (1 × 10(6) cells). Tears production was measured at baseline and once a week after treatment using phenol red impregnated threads...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28337115/hplc-dad-analysis-antinociceptive-and-anti-inflammatory-properties-of-the-ethanolic-extract-of-hyptis-umbrosa-in-mice
#9
Klécia S Dos Anjos, Heitor G Araújo-Filho, Marcelo C Duarte, Vicente C O Costa, Josean F Tavares, Marcelo S Silva, Jackson R G S Almeida, Nathália A C Souza, Larissa A Rolim, Irwin R A Menezes, Henrique D M Coutinho, Jullyana S S Quintans, Lucindo J Quintans-Júnior
Hyptis umbrosa (syn. Mesosphaerum sidifolium) (Lamiaceae Family) has been used to treat several conditions such as gastrointestinal disorders, skin infections, nasal congestion, fever and cramps. The objective of this study was to evaluate the chemical composition, analgesic and anti-inflammatory profiles of ethanol extract from leaves of Hyptis umbrosa (EEB). HPLC-DAD was used to determine the fingerprint chromatogram of the extract. Male Swiss mice were orally pretreated with EEB (100, 200 or 400 mg/kg; 60 min before initiating algesic stimulation) and antinociceptive activity was assessed using the acetic acid-induced writhing model, formalin test and hyperalgesia induced by glutamate or capsaicin...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28298071/protective-effect-of-dracontium-dubium-against-bothrops-asper-venom
#10
Daneiva Caro, Yanet Ocampo, Jenny Castro, Lia Barrios, Rubén Salas, Luis A Franco
In Colombia, Bothrops asper is responsible for 70-90% of ophidians accidents reported annually. Envenoming occurs mainly in rural areas where both antivenom and health centers are scarce. Thus, patients are frequently treated by local healers that employ medicinal herbs; including several species belonging to Dracontium genus. In this work, we evaluated the neutralizing activity of Dracontium dubium Kunth against the lethal, inflammatory, coagulant and hemolytic effects produced by B. asper venom. Mice treated with D...
March 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28288933/effect-of-lyophilized-prune-extract-on-hyperhomocysteinemia-in-mice
#11
Hayate Haddadi-Guemghar, Asma Tlili, Julien Dairou, Jean-Louis Paul, Khodir Madani, Nathalie Janel
Altered homocysteine metabolism defined as hyperhomocysteinemia is implicated as pathogenic factor in several cardiovascular diseases and atherosclerosis. The purpose of this study was to investigate the efficacy of prune extract, a good source of phenolic antioxidants, on lowering plasma homocysteine level in male hyperhomocysteinemic mice from average weight of 28 g. The administration of lyophilized prune extract was carried out by intraperitoneal injection one day preceding and one hour before sacrifice of mice...
March 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28274416/solid-cation-exchange-phase-to-remove-interfering-anthocyanins-in-the-analysis-of-other-bioactive-phenols-in-red-wine
#12
Letícia Flores da Silva, Celito Crivellaro Guerra, Diandra Klein, Ana Maria Bergold
Bioactive phenols (BPs) are often targets in red wine analysis. However, other compounds interfere in the liquid chromatography methods used for this analysis. Here, purification procedures were tested to eliminate anthocyanin interference during the determination of 19 red-wine BPs. Liquid chromatography, coupled to a diode array detector (HPLC-DAD) and a mass spectrometer (UPLC-MS), was used to compare the direct injection of the samples with solid-phase extractions: reversed-phase (C18) and strong cation-exchange (SCX)...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28272351/methyl-gallate-inhibits-osteoclast-formation-and-function-by-suppressing-akt-and-btk-plc%C3%AE-2-ca-2-signaling-and-prevents-lipopolysaccharide-induced-bone-loss
#13
Jong Min Baek, Ju-Young Kim, Chang Hoon Lee, Kwon-Ha Yoon, Myeung Su Lee
In the field of bone research, various natural derivatives have emerged as candidates for osteoporosis treatment by targeting abnormally elevated osteoclastic activity. Methyl gallate, a plant-derived phenolic compound, is known to have numerous pharmacological effects against inflammation, oxidation, and cancer. Our purpose was to explore the relation between methyl gallate and bone metabolism. Herein, we performed screening using methyl gallate by tartrate resistant acid phosphatase (TRAP) staining and revealed intracellular mechanisms responsible for methyl gallate-mediated regulation of osteoclastogenesis by Western blotting and quantitative reverse transcription polymerase chain reaction (RT-PCR)...
March 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28262620/effects-of-jasminum-multiflorum-leaf-extract-on-rodent-models-of-epilepsy-motor-coordination-and-anxiety
#14
Jonas I Addae, Ramish Pingal, Kheston Walkins, Renee Cruickshank, Farid F Youssef, Shivananda B Nayak
Jasmine flowers and leaves are used extensively in folk medicine in different parts of the world to treat a variety of diseases. However, there are very few published reports on the neuropsychiatric effects of Jasmine extracts. Hence, the objectives of the present study were to examine the effects of an alcohol extract of Jasminum multiflorum leaves on topically-applied bicuculline (a model of acute simple partial epilepsy) and maximal electroshock (MES, a model of generalized tonic-clonic seizure) in male Sprague-Dawley rats...
March 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28255862/investigation-of-thymol-effect-on-learning-and-memory-impairment-induced-by-intrahippocampal-injection-of-amyloid-beta-peptide-in-high-fat-diet-fed-rats
#15
Masoumeh Asadbegi, Parichehreh Yaghmaei, Iraj Salehi, Alireza Komaki, Azadeh Ebrahim-Habibi
Obesity and consumption of a high fat diet (HFD) are known to increase the risk of Alzheimer's disease (AD). In the present study, we have examined the protective and therapeutic effects of thymol (main monoterpene phenol found in thyme essential oil) on a HFD-fed rat model of AD. Fourty adult male Wistar rats were randomly assigned to 5 groups:(n = 8 rats/group): group 1, control, consumed an ordinary diet, group 2 consumed a HFD for 8 weeks, then received phosphate-buffered saline (PBS) via intrahippocampal (IHP) injection, group 3 consumed HFD for 8 weeks, then received beta-amyloid (Aβ)1-42 via IHP injections to induce AD, group 4 consumed HFD for 8 weeks, then received Aβ1-42, and was treated by thymol (30 mg/kg in sunflower oil) daily for 4 weeks, and group 5 consumed HFD for 8 week, then received Aβ1-42 after what sunflower oil was administered by oral gavage daily for 4 weeks...
March 2, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28247273/morus-alba-leaf-extract-mediates-neuroprotection-against-glyphosate-induced-toxicity-and-biochemical-alterations-in-the-brain
#16
Olfa Rebai, Manel Belkhir, Adnen Boujelben, Sami Fattouch, Mohamed Amri
Recent studies demonstrate that glyphosate exposure is associated with oxidative stress and some neurological disorders such as Parkinson's pathology. Therefore, phytochemicals, in particular phenolic compounds, have attracted increasing attention as potential agents for neuroprotection. In the present study, we investigate the impact of glyphosate on the rat brain following i.p. injection and the possible molecular target of neuroprotective activity of the phenolic fraction from Morus alba leaf extract (MALE) and its ability to reduce oxidative damage in the brain...
February 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28236459/k-targeted-strategy-for-isolation-of-phenolic-alkaloids-of-nelumbo-nucifera-gaertn-by-counter-current-chromatography-using-lysine-as-a-ph-regulator
#17
Yanyan Wang, Lihong Zhang, Hui Zhou, Xiuyun Guo, Shihua Wu
Counter-current chromatography (CCC) is an efficient liquid-liquid partition chromatography technique without support matrix. Despite there are many significant advancements in the CCC separation of natural products especially for non-ionic neutral compounds, CCC isolation of ionic compounds including alkaloids is still a challenging process guide by classical partition coefficients (K) or distribution ratio (KC) because their partition coefficient could not be equal to distribution ratio in common ionic conditions...
March 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28235997/centrifugeless-dispersive-liquid-liquid-microextraction-based-on-salting-out-phenomenon-as-an-efficient-method-for-determination-of-phenolic-compounds-in-environmental-samples
#18
Ehsan Mirparizi, Maryam Rajabi, Mohammad Bazregar, Alireza Asghari
A new centrifugeless dispersive liquid-liquid microextraction (DLLME) method was applied for the convenient extraction of some phenolic compounds from environmental samples. After dispersing the extracting solvent into the sample solution (10.0 mL), the mixture was passed through a small column filled with 5 g sodium chloride. As a result, phase separation was achieved via the salting-out phenomenon, and the extracting solvent was suspended on top of the sample solution. Using a low-toxic and solidifiable extracting solvent (1-dodecanol), after immersing the column into an ice bath, the extracting solvent was solidified, collected easily, and injected into an HPLC-UV instrument...
April 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28231543/date-seed-extract-ameliorates-%C3%AE-amyloid-induced-impairments-in-hippocampus-of-male-rats
#19
Farzaneh Dehghanian, Taj Pari Kalantaripour, Khadijeh Esmaeilpour, Leila Elyasi, Hakime Oloumi, Fatmeh Mehdi Pour, Majid Asadi-Shekaari
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder among the elderly. Because the existing treatments for Alzheimer's disease only offer limited symptomatic alleviation, more efficient therapeutic agents are urgently needed. Date seed is a hepatoprotective and neuroprotective agent. Date seed extract (DSE) has bioactive components like phenolics, flavonoids, and vitamins. In view of the ameliorative effects of DSE against an oxidative injury, the current study was designed to reveal whether DSE has a neuroprotective resource in the rat model of Alzheimer's disease...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28230569/procedure-oriented-torsional-anatomy-of-the-hand-for-spasticity-injection
#20
Joslyn John, John Cianca, Faye Chiou-Tan, Sindhu Pandit, Erin Furr-Stimming, Katherine H Taber
OBJECTIVES: To provide musculoskeletal ultrasound (MSKUS) images of hand anatomy in the position of hemiparetic flexion as a reference for spasticity injections. After a stroke, spasticity can result in anatomic distortion of the hand. Spasticity may require treatment with botulinum toxin or phenol injections. Anatomic distortion may decrease the accuracy of injections. Standard anatomic references are of limited utility because they are not in this spastic hemiparetic position. There presently is no anatomic reference in the literature for these spastic postures...
March 2017: Journal of Computer Assisted Tomography
keyword
keyword
99876
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"