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Phenol injections

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https://www.readbyqxmd.com/read/28236459/k-targeted-strategy-for-isolation-of-phenolic-alkaloids-of-nelumbo-nucifera-gaertn-by-counter-current-chromatography-using-lysine-as-a-ph-regulator
#1
Yanyan Wang, Lihong Zhang, Hui Zhou, Xiuyun Guo, Shihua Wu
Counter-current chromatography (CCC) is an efficient liquid-liquid partition chromatography technique without support matrix. Despite there are many significant advancements in the CCC separation of natural products especially for non-ionic neutral compounds, CCC isolation of ionic compounds including alkaloids is still a challenging process guide by classical partition coefficients (K) or distribution ratio (KC) because their partition coefficient could not be equal to distribution ratio in common ionic conditions...
February 16, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28235997/centrifugeless-dispersive-liquid-liquid-microextraction-based-on-salting-out-phenomenon-as-an-efficient-method-for-determination-of-phenolic-compounds-in-environmental-samples
#2
Ehsan Mirparizi, Maryam Rajabi, Mohammad Bazregar, Alireza Asghari
A new centrifugeless dispersive liquid-liquid microextraction (DLLME) method was applied for the convenient extraction of some phenolic compounds from environmental samples. After dispersing the extracting solvent into the sample solution (10.0 mL), the mixture was passed through a small column filled with 5 g sodium chloride. As a result, phase separation was achieved via the salting-out phenomenon, and the extracting solvent was suspended on top of the sample solution. Using a low-toxic and solidifiable extracting solvent (1-dodecanol), after immersing the column into an ice bath, the extracting solvent was solidified, collected easily, and injected into an HPLC-UV instrument...
February 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28231543/date-seed-extract-ameliorates-%C3%AE-amyloid-induced-impairments-in-hippocampus-of-male-rats
#3
Farzaneh Dehghanian, Taj Pari Kalantaripour, Khadijeh Esmaeilpour, Leila Elyasi, Hakime Oloumi, Fatmeh Mehdi Pour, Majid Asadi-Shekaari
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder among the elderly. Because the existing treatments for Alzheimer's disease only offer limited symptomatic alleviation, more efficient therapeutic agents are urgently needed. Date seed is a hepatoprotective and neuroprotective agent. Date seed extract (DSE) has bioactive components like phenolics, flavonoids, and vitamins. In view of the ameliorative effects of DSE against an oxidative injury, the current study was designed to reveal whether DSE has a neuroprotective resource in the rat model of Alzheimer's disease...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28230569/procedure-oriented-torsional-anatomy-of-the-hand-for-spasticity-injection
#4
Joslyn John, John Cianca, Faye Chiou-Tan, Sindhu Pandit, Erin Furr-Stimming, Katherine H Taber
OBJECTIVES: To provide musculoskeletal ultrasound (MSKUS) images of hand anatomy in the position of hemiparetic flexion as a reference for spasticity injections. After a stroke, spasticity can result in anatomic distortion of the hand. Spasticity may require treatment with botulinum toxin or phenol injections. Anatomic distortion may decrease the accuracy of injections. Standard anatomic references are of limited utility because they are not in this spastic hemiparetic position. There presently is no anatomic reference in the literature for these spastic postures...
February 23, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28208831/resveratrol-and-grape-extract-loaded-solid-lipid-nanoparticles-for-the-treatment-of-alzheimer-s-disease
#5
Joana A Loureiro, Stephanie Andrade, Ana Duarte, Ana Rute Neves, Joana Fontes Queiroz, Cláudia Nunes, Emmanuel Sevin, Laurence Fenart, Fabien Gosselet, Manuel A N Coelho, Maria Carmo Pereira
The aggregation of amyloid-β peptide (Aβ) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer's disease (AD). Various natural compounds have been suggested as therapeutics for AD. Among these compounds, resveratrol has aroused great interest due to its neuroprotective characteristics. Here, we provide evidence that grape skin and grape seed extracts increase the inhibition effect on Aβ aggregation. However, after intravenous injection, resveratrol is rapidly metabolized into both glucuronic acid and sulfate conjugations of the phenolic groups in the liver and intestinal epithelial cells (within less than 2 h), which are then eliminated...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28198206/nitraria-retusa-fruit-prevents-penconazole-induced-kidney-injury-in-adult-rats-through-modulation-of-oxidative-stress-and-histopathological-changes
#6
Mariem Chaâbane, Mohamed Koubaa, Nejla Soudani, Awatef Elwej, Malek Grati, Kamel Jamoussi, Tahia Boudawara, Semia Ellouze Chaabouni, Najiba Zeghal
CONTEXT: Nitraria retusa (Forssk.) Asch. (Nitrariaceae) is a medicinal plant which produces edible fruits whose antioxidant activity has been demonstrated. OBJECTIVE: The current study elucidates the potential protective effect of N. retusa fruit aqueous extract against nephrotoxicity induced by penconazole, a triazole fungicide, in the kidney of adult rats. MATERIALS AND METHODS: Adult Wistar rats were exposed either to penconazole (67 mg/kg body weight), or to N...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28168978/metal-organic-framework-mixed-matrix-disks-versatile-supports-for-automated-solid-phase-extraction-prior-to-chromatographic-separation
#7
Milad Ghani, Maria Francesca Font Picó, Shima Salehinia, Carlos Palomino Cabello, Fernando Maya, Gloria Berlier, Mohammad Saraji, Víctor Cerdà, Gemma Turnes Palomino
We present for the first time the application of metal-organic framework (MOF) mixed-matrix disks (MMD) for the automated flow-through solid-phase extraction (SPE) of environmental pollutants. Zirconium terephthalate UiO-66 and UiO-66-NH2 MOFs with different size (90, 200 and 300nm) have been incorporated into mechanically stable polyvinylidene difluoride (PVDF) disks. The performance of the MOF-MMDs for automated SPE of seven substituted phenols prior to HPLC analysis has been evaluated using the sequential injection analysis technique...
March 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28168044/anti-inflammatory-and-antioxidative-stress-effects-of-oryzanol-in-glaucomatous-rabbits
#8
Shital S Panchal, Rajesh K Patidar, Abhishek B Jha, Ahmed A Allam, Jamaan Ajarem, Shital B Butani
Purpose. γ-Oryzanol works by anti-inflammatory and radical scavenging activity as a neuroprotective, anticancer, antiulcer, and immunosuppressive agent. The present study was conducted to investigate effect of oryzanol in acute and chronic experimental glaucoma in rabbits. Methods. Effect of oryzanol was evaluated in 5% dextrose induced acute model of ocular hypertension in rabbit eye. Chronic model of glaucoma was induced with subconjunctival injection of 5% of 0.3 ml phenol. Treatment with oryzanol was given for next two weeks after induction of glaucoma...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28147306/rapid-determination-of-30-bioactive-constituents-in-xuebijing-injection-using-ultra-high-performance-liquid-chromatography-high-resolution-hybrid-quadrupole-orbitrap-mass-spectrometry-coupled-with-principal-component-analysis
#9
Lihua Zuo, Zhi Sun, Yurong Hu, Ya Sun, Wenhua Xue, Lin Zhou, Jun Zhang, Xiaoyue Bao, Zhenfeng Zhu, Guanglu Suo, Xiaojian Zhang
Xuebijing injection (XBJ) is a traditional Chinese herbal prescription widely used in the treatment of sepsis. Extensive chemical studies revealed that XBJ injection contains amino acids, phenolic acids, flavonoid glycosides, terpeneglycosides and phthalides. In this study, the applicability of ultra high performance liquid chromatography coupled with high resolution hybrid quadruple-orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) for the simultaneous quantitative analysis of 30 bioactive constituents in XueBiJing injection (XBJ) was investigated...
January 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28123461/involvement-of-nadph-oxidase-in-high-dose-phenolic-acid-induced-pro-oxidant-activity-on-rat-mesenteric-venules
#10
Wen-Yuan Du, Ying Xiao, Jian-Jing Yao, Zhe Hao, Yu-Bin Zhao
In the present study, we investigated the potential role of phenolic acids in initiating oxidative damage to microvascular endothelial cells and the underlying mechanism mediating the pro-oxidant action. Male Wistar rats received high doses of phenolic acid [caffeic acid (CA), salvianolic acid B (SAB), chlorogenic acid (ChA) or ferulic acid (FA)]. The creation of reactive oxygen species in mesenteric microcirculation endothelial cells and adherent leukocytes along with venules were assessed using intravital microscopy...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28109088/antioxidant-evaluation-and-composition-analysis-of-extracts-from-fuzhuan-brick-tea-and-its-comparison-with-two-instant-tea-products
#11
Qing-An Zhang, Xiao-Li Zhang, Yan-Ying Yan, Xue-Hui Fan
In this paper, the antioxidant capacities and compositions of two commercialized tea products and extracts from Fuzhuanbrick tea (FBT) were investigated using three HPLC methods comparing the retention times of injected standards. Principal component analysis and DPPH-spiking HPLC analysis were used to analyze correlation between antioxidant capacity and the compounds detected to screen which compounds contribute to antioxidant activity. Results indicated that all samples contained high amounts of polysaccharides, phenols, and flavonoids and had good antioxidant activity and a high level of correlation among them...
January 21, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28095842/cactus-opuntia-humifusa-water-extract-ameliorates-loperamide-induced-constipation-in-rats
#12
Sung Hee Han, Kyungmi Park, Eun Young Kim, So Hyun Ahn, Hyun-Sun Lee, Hyung Joo Suh
BACKGROUND: Korean cactus Cheonnyuncho (Opuntia humifusa) is rich in pectin, phenols, flavonoids, and minerals such as calcium and phosphorus. Some Koreans drink Cheonnyuncho juice prepared by grinding Cheonnyuncho with water. Cheonnyuncho is well known for its functional properties and antioxidant effects, but its effect on constipation has not been sufficiently studied. METHODS: Loperamide (2 mg/kg) was injected subcutaneously to induce constipation in rats. The animals were divided into four groups: a normal group (NOR), constipation control group (CON), and two constipation groups receiving the Cheonnyuncho extract (CE) at two different concentrations in drinking water, 3% (L-CE group) and 6% (H-CE group), for 25 days...
January 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28059912/phenol-injection-versus-excision-with-open-healing-in-pilonidal-disease-a-prospective-randomized-trial
#13
Ismail Calikoglu, Kamil Gulpinar, Derya Oztuna, Atilla Halil Elhan, Osman Dogru, Cihangir Akyol, Bulent Erkek, Mehmet Ayhan Kuzu
BACKGROUND: Minimally invasive procedures may be an alternative to surgical excisions for pilonidal disease. OBJECTIVE: The aim of the study was to compare phenol injection versus excision with open healing technique. DESIGN: This is a prospective randomized study (ACTRN12612000868886). SETTINGS: This study was conducted at the Ankara University and Ufuk University Departments of Surgery. PATIENTS: One hundred forty patients were randomly assigned to phenol injection (n = 70) or excision with open healing (n = 70)...
February 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28043811/honokiol-induces-proteasomal-degradation-of-aml1-eto-oncoprotein-via-increasing-ubiquitin-conjugase-ubch8-expression-in-leukemia
#14
Bin Zhou, Haiying Li, Chongyun Xing, Haige Ye, Jianhua Feng, Jianbo Wu, Zhongqiu Lu, Jing Fang, Shenmeng Gao
AML1-ETO is the most common oncoprotein leading to acute myeloid leukemia (AML), in which 5-year survival rate is only about 30%. However, currently there are no specific therapies for AML patients with AML1-ETO. Here, we report that AML1-ETO protein is rapidly degraded by Honokiol (HNK), a natural phenolic compound isolated from the plant Magnolia officinalis. HNK induced the degradation of AML1-ETO in a concentration- and time-dependent manner in leukemic cell lines and primary AML blasts with t(8;21) translocation...
December 30, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28034282/evaluation-of-antidiabetic-activity-of-carnosol-phenolic-diterpene-in-rosemary-in-streptozotocin-induced-diabetic-rats
#15
Tahere Farkhondeh, Saeed Samarghandian, Abasalt Borji
Carnosol (CS) is an ortho-diphenolic diterpene in rosemary with great antioxidant potential. This study was designed to investigate the hypolipidemic, anti-oxidant, and anti-diabetic activities of CS. In our experiment, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, three CS (1, 5, 10 mg/kg/day)-treated diabetic groups. On the first day of the study, the diabetic groups were given streptozotocin (STZ) in a single intraperitoneal (i.p.) injection at a dose of 60 mg/kg for induction of diabetes...
December 29, 2016: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28003341/chicoric-acid-supplementation-prevents-systemic-inflammation-induced-memory-impairment-and-amyloidogenesis-via-inhibition-of-nf-%C3%AE%C2%BAb
#16
Qian Liu, Yuwei Chen, Chun Shen, Yating Xiao, Yutang Wang, Zhigang Liu, Xuebo Liu
Chicoric acid (CA), a natural phenolic acid extracted from chicory and the echinacea (purple coneflower) plant (Echinacea purpurea), has been regarded as a nutraceutical that has powerful antioxidant and antiobesity activities. We investigated the inhibitory effects of CA on systemic inflammation-induced neuroinflammation, amyloidogenesis, and cognitive impairment. C57BL/6J mice were treated with 0.05% CA in the drinking water for 45 d. The mice were then treated by intraperitoneal injection of LPS (lipopolysaccharide)...
December 21, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27988851/outcomes-following-sclerotherapy-for-mucosal-rectal-prolapse-with-oily-phenol-injection-single-centre-review
#17
Rohini Sahay, Govind Murthi, Richard Lindley
AIM OF THE STUDY: To review the outcomes of injection sclerotherapy with oily phenol for mucosal rectal prolapse. METHODS: Retrospective case note review of all children who underwent sclerotherapy with oily phenol injection as primary surgical intervention for mucosal rectal prolapse, from January 2007 to December 2015. MAIN RESULTS: A total of 31 patients were identified. Mean age at presentation was 4.8 years (range 5 months-12 years)...
December 17, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27965009/dual-reductive-oxidative-electrochemistry-liquid-chromatography-mass-spectrometry-towards-peptide-and-protein-modification-separation-and-identification
#18
Lars Büter, Lisa M Frensemeier, Martin Vogel, Uwe Karst
A new hyphenated technique based on on-line dual (oxidative and reductive) electrochemistry coupled to liquid chromatography and high resolution electrospray mass spectrometry is presented. Two liquid streams are combined, with one containing a disulfide, which is reduced to the respective thiol in an electrochemical cell based on a titanium working electrode. The other stream contains phenol, which is electrochemically activated to benzoquinone on a boron-doped diamond working electrode. Upon combination of the two streams, a Michael addition takes places, leading to the covalent coupling of thiol to quinone...
January 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27951473/oleuropein-aglycone-enhances-ucp1-expression-in-brown-adipose-tissue-in-high-fat-diet-induced-obese-rats-by-activating-%C3%AE-adrenergic-signaling
#19
Yuriko Oi-Kano, Yusaku Iwasaki, Toshiyuki Nakamura, Tatsuo Watanabe, Tsuyoshi Goto, Teruo Kawada, Kenichi Watanabe, Kazuo Iwai
Oleuropein is the pungent principle of raw olives. Oleuropein aglycone (OA) is a major phenolic compound in extra virgin olive oil and the absorbed form of oleuropein. We aimed to determine the mechanism underlying the nutritional effects of oleuropein and OA on interscapular brown adipose tissue (IBAT) in rats with high-fat (HF) diet-induced obesity by examining the agonistic activity of oleuropein and OA toward the transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1). Four-week-old male Sprague-Dawley rats were fed an HF (palm oil 30% wt:wt) diet alone or with oleuropein (HF-O, 1 g/kg diet) for 28 days...
November 23, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27941199/-peripheral-nerves-phenolisation-in-spasticity-management-forgotten-art-or-interesting-perspective
#20
Jerzy Kiwerski, Karolina Turżańska, Ryszard Pluta, Małgorzata Drelich, Aneta Zarębska, Mirosław Jabłoński
INTRODUCTION: Spasticity is one of the most common obstacles in the process of rehabilitation after permanent central nervous system injury. Statistics show that the problem affects more than 12 billion people all over the world. Treatment of spasticity is necessary for proper rehabilitation, prevention of secondary disability, pain management and also strongly influences quality of life. Nowadays the most common formula used for the treatment of local spasticity is injection of botulinum toxin...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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