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https://www.readbyqxmd.com/read/28928658/anti-inflammatory-antinociceptive-and-antioxidant-activities-of-methanol-and-aqueous-extracts-of-anacyclus-pyrethrum-roots
#1
Houria Manouze, Otmane Bouchatta, A Chemseddoha Gadhi, Mohammed Bennis, Zahra Sokar, Saadia Ba-M'hamed
Anacyclus pyrethrum (L.) is a plant widely used in Moroccan traditional medicine to treat inflammatory and painful diseases. The objective of the present study was to evaluate the antinociceptive, anti-inflammatory and antioxidant activities of aqueous and methanol extracts of Anacyclus pyrethrum roots (AEAPR and MEAPR). The anti-inflammatory effect of AEAPR and MEAPR was determined in xylene-induced ear edema and Complete Freund's Adjuvant (CFA)-induced paw edema. The antinociceptive activity of AEAPR and MEAPR (125, 250, and 500 mg/kg) administered by gavage was examined in mice by using acetic acid-induced writhing, hot plate, and formalin tests, and the mechanical allodynia were assessed in CFA-induced paw edema...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28921579/material-basis-studies-of-anti-influenza-a-active-ingredients-in-tanreqing-injection
#2
Haiyan Zhu, Mingchang Chen, Xunlong Shi, Chenchen Shi, Chenggang Huang
Tanreqing Injection (TRQ) has been used primarily in treating infections of the upper respiratory tract and serious influenza in China, as a classical compound herbal recipe. TRQ had been demonstrated its effects of clearing heat, eliminating phlegm, detoxification, reducing inflammation and alleviating cough. The survival rate, histopathology of lungs and viral titers in mice were evaluated in this study to verify the curative effect of TRQ. However, there is not enough information about the components. In the present study, a high-performance and practical LC/QTOF/MS method was developed for characterization and identification of the natural ingredients in TRQ...
September 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28919499/ultrasound-guidance-for-phenol-neurolysis-to-the-musculocutaneous-nerve
#3
Mary E Matsumoto, Jessica Berry, Herbie Yung, Martha Matsumoto, Michael C Munin
OBJECTIVE: This study compared electrical stimulation only (e-stim) to ultrasound with e-stim (US) guidance in phenol neurolysis of the musculocutaneous nerve (MCN) for elbow flexor spasticity. We also evaluated the US appearance of MCN in this population. DESIGN: Retrospective review SETTING: University hospital outpatient clinic PARTICIPANTS: Adult patients (N=167) receiving phenol neurolysis of the MCN for treatment of elbow flexor spasticity between 1997 to 2014 and adult control subjects...
September 14, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28918324/simultaneous-determination-and-pharmacokinetic-study-of-twelve-bioactive-compounds-in-rat-plasma-after-intravenous-administration-of-xuebijing-injection-by-uhplc-q-orbitrap-hrms
#4
Lihua Zuo, Qiuyue Zhong, Zhenhui Wang, Zhi Sun, Lin Zhou, Zhuolun Li, Tanye Xu, Yingying Shi, Jinfa Tang, Shuzhang Du, Xiaojian Zhang
Xuebijing injection (XBJ) is a traditional Chinese herbal prescription widely used in the treatment of sepsis. Extensive studies revealed that the major bioactive constituents of XBJ injection, including phenolic acids, flavonoids, monoterpene glycosides, lactones and organic acids, play an important role in the treatment. In this study, a rapid, sensitive and accurate ultra high performance liquid chromatography - Q Exactive hybrid quadrupole - orbitrap high-resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS) method was developed for simultaneous determination of twelve bioactive compounds in rat plasma after intravenous administration of XBJ injection...
September 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28855941/evaluation-of-fibrinolytic-and-antioxidant-effects-of-allium-affine-hydroalcoholic-extract
#5
Masoud Sadeghi, Leila Safaeian, Mohammadreza Aghaye Ghazvini, Mojtaba Ramezani
Allium affine is a member of Amaryllidaceae family, which grows wildly in some western regions of Iran. Limited information is available about the pharmacological activities of this plant. The present study aimed to evaluate the fibrinolytic and antioxidant effects of hydroalcoholic extract of A. affine aerial parts. The in vitro antioxidant properties of the extract were evaluated by total phenolic content assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and ferric reducing antioxidant power (FRAP) assay...
August 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28836990/wound-healing-effect-of-euphorbia-hirta-linn-euphorbiaceae-in-alloxan-induced-diabetic-rats
#6
Riazul Haque Tuhin, Marium Begum, Sohanur Rahman, Rubaba Karim, Taslima Begum, Siraj Uddin Ahmed, Ronia Mostofa, Amir Hossain, Mohamed Abdel-Daim, Rayhana Begum
BACKGROUND: Euphorbia hirta linn., is a species of Euphorbiaceae family. They are known as asthma plant, barokhervi. The plant E. hirta is famous for its medicinal importance among the tribal population. It is a common practice to use the whole to heal wounds. Several pharmacological properties including antiseptic, anti-inflammatory, antidibetic, antispasmodic, antibacterial, antiviral, antifungal, anticonvulsant, nootropic, antifertility and aphrodisiac properties have already been reported for this plant...
August 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28812474/protective-effect-of-raisin-currant-against-spatial-memory-impairment-and-oxidative-stress-in-alzheimer-disease-model
#7
Mohammad Gol, Davoud Ghorbanian, Nabiollah Soltanpour, Jamshid Faraji, Mohsen Pourghasem
OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive pathological changes of the brain. A number of studies demonstrated compelling evidence of the importance of oxidative processes in AD pathogenesis. Raisin contains polyphenol, phenolic acid, and tannin compounds, which have antioxidant and anti-inflammatory properties. The present study was aimed to evaluate the protective effect of raisin on neurobehavioral and histological changes in rats with Alzheimer...
August 16, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28810691/improvement-of-implantation-potential-in-mouse-blastocysts-derived-from-ivf-by-combined-treatment-with-prolactin-epidermal-growth-factor-and-4-hydroxyestradiol
#8
Miki Takeuchi, Misato Seki, Etsuko Furukawa, Akihito Takahashi, Kyosuke Saito, Mitsuru Kobayashi, Kenji Ezoe, Emiko Fukui, Midori Yoshizawa, Hiromichi Matsumoto
STUDY QUESTION: Can supplementation of medium with prolactin (PRL), epidermal growth factor (EGF) and 4-hydroxyestradiol (4-OH-E2) prior to embryo transfer improve implantation potential in mouse blastocysts derived from IVF? SUMMARY ANSWER: Combined treatment with PRL, EGF and 4-OH-E2 improves mouse blastocyst implantation rates, while alone, each factor is ineffective. WHAT IS KNOWN ALREADY: Blastocyst dormancy during delayed implantation caused by ovariectomy is maintained by continued progesterone treatment in mice, and estrogen injection rapidly activates blastocysts to implantation-induced status in vivo...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28806668/combination-of-electrochemical-biosensor-and-textile-threads-a-microfluidic-device-for-phenol-determination-in-tap-water
#9
F R Caetano, E A Carneiro, D Agustini, L C S Figueiredo-Filho, C E Banks, M F Bergamini, L H Marcolino-Junior
Microfluidic devices constructed using low cost materials presents as alternative for conventional flow analysis systems because they provide advantages as low consumption of reagents and samples, high speed of analysis, possibility of portability and the easiness of construction and maintenance. Herein, is described for the first time the use of an electrochemical biosensor for phenol detection combined with a very simple and efficient microfluidic device based on commercial textile threads. Taking advantages of capillary phenomena and gravity forces, the solution transportation is promoted without any external forces or injection pump...
July 29, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28806081/chlorination-kinetics-of-11-nor-9-carboxy-%C3%AE-9-tetrahydrocannabinol-effects-of-ph-and-humic-acid
#10
Allison L Mackie, Yu Ri Park, Graham A Gagnon
The main psychoactive compound in marijuana, Δ(9)-tetrahydrocannabinol (THC), and its metabolites are emerging organic contaminants that have been detected in waste and surface waters. As legalization of marijuana for medical and recreational use continues, the effects of increased use and potency of marijuana on water and wastewater treatment processes and the environment should be considered. This study examined degradation kinetics of the main urinary metabolite of THC, 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THC-COOH) with chlorine...
August 29, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28764088/a-novel-flow-injection-chemiluminescence-method-for-automated-and-miniaturized-determination-of-phenols-in-smoked-food-samples
#11
Christina Vakh, Ekaterina Evdokimova, Aleksei Pochivalov, Leonid Moskvin, Andrey Bulatov
An easily performed fully automated and miniaturized flow injection chemiluminescence (CL) method for determination of phenols in smoked food samples has been proposed. This method includes the ultrasound assisted solid-liquid extraction coupled with gas-diffusion separation of phenols from smoked food sample and analytes absorption into a NaOH solution in a specially designed gas-diffusion cell. The flow system was designed to focus on automation and miniaturization with minimal sample and reagent consumption by inexpensive instrumentation...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28762200/rapid-acting-and-human-insulins-hexamer-dissociation-kinetics-upon-dilution-of-the-pharmaceutical-formulation
#12
Klaus Gast, Anja Schüler, Martin Wolff, Anja Thalhammer, Harald Berchtold, Norbert Nagel, Gudrun Lenherr, Gerrit Hauck, Robert Seckler
PURPOSE: Comparison of the dissociation kinetics of rapid-acting insulins lispro, aspart, glulisine and human insulin under physiologically relevant conditions. METHODS: Dissociation kinetics after dilution were monitored directly in terms of the average molecular mass using combined static and dynamic light scattering. Changes in tertiary structure were detected by near-UV circular dichroism. RESULTS: Glulisine forms compact hexamers in formulation even in the absence of Zn(2+)...
July 31, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28761790/potential-wound-healing-activity-of-quercus-infectoria-formulation-in-diabetic-rats
#13
Julalak Chokpaisarn, Sasitorn Chusri, Thanaporn Amnuaikit, Wandee Udomuksorn, Supayang Piyawan Voravuthikunchai
BACKGROUND: Quercus infectoria G. Olivier (Fagaceae) nutgalls have been widely employed in traditional Asian medicine for several treatments, especially wounds and skin disorders. However, the effects of this plant on wound healing have not yet been clearly elucidated. This present work was focused on utilization of Quercus infectoria (Qi) as a topical agent for chronic wound treatment. METHODS: Twenty Qi formulations (QiFs) were pharmaceutically formulated and antibacterial activity of all formulations was performed...
2017: PeerJ
https://www.readbyqxmd.com/read/28748169/evaluation-of-fibrinolytic-and-antioxidant-effects-of-allium-elburzense-bulb-extracts
#14
Leila Safaeian, Behzad Zolfaghari, Mohammadreza Aghaye-Ghazvini, Mahya Behnampour
OBJECTIVE: Allium elburzense is an endemic plant of the family Amaryllidaceae that grows wild in northern Iran with some nutritional and medicinal applications. The present study was aimed to investigate the fibrinolytic and antioxidant effects of A. elburzense bulb extracts. MATERIALS AND METHODS: Hydroalcoholic, aqueous, chloroformic and butanolic extracts were evaluated in this research. In vitro antioxidant assays were performed using total phenolic, DPPH, and FRAP methods...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28738554/amperometric-detector-for-gas-chromatography-based-on-a-silica-sol-gel-solid-electrolyte
#15
William H Steinecker, Krzysztof Miecznikowski, Pawel J Kulesza, Zechariah D Sandlin, James A Cox
An electrochemical cell comprising a silica sol-gel solid electrolyte, a working electrode that protrudes into a gas phase, and reference and counter electrodes that contact the solid electrolyte comprises an amperometric detector for gas chromatography. Under potentiostatic conditions, a current related to the concentration of an analyte in the gas phase is produced by its oxidation at the three-phase boundary among the sol-gel, working electrode, and the gas phase. The sol-gel is processed to contain an electrolyte that also serves as a humidistat to maintain a constant water activity even in the presence the gas chromatographic mobile phase...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28716516/hypertonia
#16
Sarah Helen Evans, Mark William Cameron, Justin Michael Burton
Hypertonia is the abnormal increase in muscle tone as a result of upper motor neuron lesions. There are three following clinical types: spasticity, dystonia, and rigidity. Management of hypertonia is individualized and should be directed by the patient and/or family׳s goals of care as well as the underlying cause of the hypertonia. Treatment options include stretching, strengthening, positioning, oral medications, botulinum toxin injections, phenol injections, as well as surgical procedures. Without effective management, hypertonia can result in muscle imbalance, abnormal movement patterns, pain, joint contracture, joint deformity, and ultimately negatively impact a patient׳s function...
July 14, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28712549/determination-of-trace-amounts-of-g-type-nerve-agents-in-aqueous-samples-utilizing-in-vial-instantaneous-derivatization-and-liquid-chromatography-tandem-mass-spectrometry
#17
Avi Weissberg, Moran Madmon, Maor Elgarisi, Shai Dagan
A methodology for sensitive determination of sarin (GB), soman (GD) and cyclosarin (GF) chemical warfare agents in aqueous media was developed. The method incorporates direct derivatization with 2-[(dimethylamino)methyl]phenol (2-DMAMP), a commercially available, water-soluble reagent, followed by LC-ESI-MS/MS analysis in the positive ion mode. Five derivatization agents were characterized for their MS/MS fragmentation pattern, and their reaction time, temperature and derivatization-reagent amount were optimized...
July 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28695411/protective-effects-of-curcumin-against-rotenone-induced-rat-model-of-parkinson-s-disease-in-vivo-electrophysiological-and-behavioral-study
#18
L V Darbinyan, L E Hambardzumyan, K V Simonyan, V A Chavushyan, L P Manukyan, S A Badalyan, N Khalaji, V H Sarkisian
Curcumin is a naturally occurring phenolic yellow chemical isolated from the rhizomes of the plant Curcuma longa (turmeric), and is a major component of the spice turmeric. Curcumin has protective effects against rotenone-induced neural damage in Parkinson's disease (PD). The present study aims at providing new evidence for the validity of the rotenone rat model of PD by examining whether neuronal activity in the hippocampus is altered. Male albino rats were treated with rotenone injections (2.5 mg/ml intraperitoneally) for 21 days...
July 10, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28683791/in-vivo-administration-of-urolithin-a-and-b-prevents-the-occurrence-of-cardiac-dysfunction-in-streptozotocin-induced-diabetic-rats
#19
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall'Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio
BACKGROUND: Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy. In a rat model of early diabetes, we evaluated whether in vivo administration of urolithin A (UA) or urolithin B (UB), the main gut microbiota phenolic metabolites of ellagitannin-rich foods, can reduce diabetes-induced microenvironmental changes in myocardial tissue, preventing cardiac functional impairment...
July 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28674855/carnosic-acid-attenuates-rankl-induced-oxidative-stress-and-osteoclastogenesis-via-induction-of-nrf2-and-suppression-of-nf-%C3%AE%C2%BAb-and-mapk-signalling
#20
Dinesh Thummuri, V G M Naidu, Pradip Chaudhari
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor, which plays an important role in the cellular defense against oxidative stress by induction of anti-oxidant and cytoprotective enzymes. In the current study, we sought to investigate the osteoprotective effect of carnosic acid (CA), a phenolic (catecholic) diterpene. It is widely identified for its electrophilic nature under oxidative stress conditions and thus anticipated to counter osteoporosis by facilitation of Nrf2 signalling...
July 4, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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