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Post-stroke cognitive impairment

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https://www.readbyqxmd.com/read/28302914/new-insights-into-mechanisms-of-small-vessel-disease-stroke-from-genetics
#1
REVIEW
Rhea Tan, Matthew Traylor, Loes Rutten-Jacobs, Hugh Markus
Cerebral small vessel disease (SVD) is a common cause of lacunar strokes, vascular cognitive impairment (VCI) and vascular dementia. SVD is thought to result in reduced cerebral blood flow, impaired cerebral autoregulation and increased blood-brain barrier (BBB) permeability. However, the molecular mechanisms underlying SVD are incompletely understood. Recent studies in monogenic forms of SVD, such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 'sporadic' SVD have shed light on possible disease mechanisms in SVD...
April 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28220928/malt-combined-motor-and-language-therapy-tool-for-brain-injury-patients-using-kinect
#2
Maitreyee Wairagkar, Rachel McCrindle, Holly Robson, Lotte Meteyard, Malcom Sperrin, Andy Smith, Moyra Pugh
BACKGROUND: The functional connectivity and structural proximity of elements of the language and motor systems result in frequent co-morbidity post brain injury. Although rehabilitation services are becoming increasingly multidisciplinary and "integrated", treatment for language and motor functions often occurs in isolation. Thus, behavioural therapies which promote neural reorganisation do not reflect the high intersystem connectivity of the neurologically intact brain. As such, there is a pressing need for rehabilitation tools which better reflect and target the impaired cognitive networks...
February 21, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28218337/long-term-outcome-after-reperfusion-treated-stroke
#3
Oscar Mühr, Hanna C Persson, Katharina S Sunnerhagen
OBJECTIVE: To explore motor function, health-related quality of life and impact on activities of daily living 5 and 6 years after reperfusion treatment in patients with stroke. METHODS: A total of 75 patients with first-time stroke received either thrombectomy or thrombolytic treatment at the Sahlgrenska University Hospital in Gothenburg during an 18-month period in 2009-2010. Follow-up involved questionnaires and clinical examinations, 5 and 6 years post-stroke...
February 17, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28218007/cognitive-communication-disorder-following-right-hemisphere-stroke-exploring-rehabilitation-access-and-outcomes
#4
Ronelle Hewetson, Petrea Cornwell, David Shum
BACKGROUND: Rehabilitation positively influences return to activities and social roles in people with aphasia. The cognitive-communication disorder (CCD) found following a right hemisphere stroke has been less extensively researched with rehabilitation access and outcomes yet to be determined. OBJECTIVES: To document rehabilitation access and outcomes for people with CCD post-stroke; and compare outcomes based on presence (viz CCD; aphasia) or absence of communication impairment...
February 20, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28144726/-delirium-in-stroke-patients-critical-analysis-of-statistical-procedures-for-the-identification-of-risk-factors
#5
P Nydahl, N G Margraf, A Ewers
BACKGROUND: Delirium is a relevant complication following an acute stroke. It is a multifactor occurrence with numerous interacting risk factors that alternately influence each other. PROBLEM: The risk factors of delirium in stroke patients are often based on limited clinical studies. The statistical procedures and clinical relevance of delirium related risk factors in adult stroke patients should therefore be questioned. METHOD: This secondary analysis includes clinically relevant studies that give evidence for the clinical relevance and statistical significance of delirium-associated risk factors in stroke patients...
January 31, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28131163/the-test-accuracy-of-the-montreal-cognitive-assessment-moca-by-stroke-lateralisation
#6
Edgar Chan, Samantha Altendorff, Colm Healy, David J Werring, Lisa Cipolotti
BACKGROUND: The Montreal Cognitive Assessment (MoCA) is an increasingly popular screening tool for detecting cognitive impairment post-stroke. However its' test accuracy by stroke lateralisation is as yet unknown. AIM: Our aim was to investigate whether the test accuracy of the MoCA differs by stroke lateralisation across different cognitive domains. METHODS: We retrospectively examined the cognitive profiles of 228 subacute stroke patients (86 Left, 142 Right), comparing MoCA-total and domain-specific scores with performance on detailed neuropsychological assessment...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28127524/severe-carotid-artery-stenosis-evaluated-by-ultrasound-is-associated-with-post-stroke-vascular-cognitive-impairment
#7
Xuefeng Li, Xiangling Ma, Jing Lin, Xiangqin He, Feng Tian, Dongmei Kong
BACKGROUND: Acute ischemic stroke has been recognized as one key cause of vascular cognitive impairment (VCI). The purpose of this study was to evaluate the correlation between carotid artery stenosis and post VCI in acute ischemic stroke patients. METHODS: In this study, B-mode ultrasound was applied to measure the degree of carotid artery stenosis. After 1 year, the stroke patients' cognitive function was assessed by the mini-mental state examination (MMSE) score...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28120733/prediction-of-post-stroke-dementia-using-ninds-csn-5-minute-neuropsychology-protocol-in-acute-stroke
#8
Jae-Sung Lim, Mi Sun Oh, Ju-Hun Lee, San Jung, Chulho Kim, Min Uk Jang, Sang-Hwa Lee, Yeo Jin Kim, Yerim Kim, Jaeseol Park, Yeonwook Kang, Kyung-Ho Yu, Byung-Chul Lee
BACKGROUND: The National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute neuropsychology protocol consists of only verbal tasks, and is proposed as a brief screening method for vascular cognitive impairment. We evaluated its feasibility within two weeks after stroke and ability to predict the development of post-stroke dementia (PSD) at 3 months after stroke. METHOD: We prospectively enrolled subjects with ischemic stroke within seven days of symptom onset who were consecutively admitted to 12 university hospitals...
January 25, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28103638/music-interventions-for-acquired-brain-injury
#9
REVIEW
Wendy L Magee, Imogen Clark, Jeanette Tamplin, Joke Bradt
BACKGROUND: Acquired brain injury (ABI) can result in impairments in motor function, language, cognition, and sensory processing, and in emotional disturbances, which can severely reduce a survivor's quality of life. Music interventions have been used in rehabilitation to stimulate brain functions involved in movement, cognition, speech, emotions, and sensory perceptions. An update of the systematic review published in 2010 was needed to gauge the efficacy of music interventions in rehabilitation for people with ABI...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28095900/post-stroke-dementia-a-comprehensive-review
#10
REVIEW
Milija D Mijajlović, Aleksandra Pavlović, Michael Brainin, Wolf-Dieter Heiss, Terence J Quinn, Hege B Ihle-Hansen, Dirk M Hermann, Einor Ben Assayag, Edo Richard, Alexander Thiel, Efrat Kliper, Yong-Il Shin, Yun-Hee Kim, SeongHye Choi, San Jung, Yeong-Bae Lee, Osman Sinanović, Deborah A Levine, Ilana Schlesinger, Gillian Mead, Vuk Milošević, Didier Leys, Guri Hagberg, Marie Helene Ursin, Yvonne Teuschl, Semyon Prokopenko, Elena Mozheyko, Anna Bezdenezhnykh, Karl Matz, Vuk Aleksić, DafinFior Muresanu, Amos D Korczyn, Natan M Bornstein
Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, with few PSD-specific instruments. Choice will depend on purpose of assessment, with differing instruments needed for brief screening (e.g., Montreal Cognitive Assessment) or diagnostic formulation (e...
January 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28067185/effect-of-formal-education-on-vascular-cognitive-impairment-after-stroke-a-meta-analysis-and-study-in-young-stroke-patients
#11
Roy P C Kessels, Willem Sake Eikelboom, Pauline Schaapsmeerders, Noortje A M Maaijwee, Renate M Arntz, Ewoud J van Dijk, Frank-Erik de Leeuw
OBJECTIVES: The extent of vascular cognitive impairment (VCI) after stroke varies greatly across individuals, even when the same amount of brain damage is present. Education level is a potentially protective factor explaining these differences, but results on its effects on VCI are inconclusive. METHODS: First, we performed a meta-analysis on formal education and VCI, identifying 21 studies (N=7770). Second, we examined the effect of formal education on VCI in young-stroke patients who were cognitively assessed on average 11...
January 9, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28056466/subacute-subclinical-brain-infarctions-after-transcatheter-aortic-valve-implantation-negatively-impact-cognitive-function-in-long-term-follow-up
#12
Alexander Ghanem, Jonas Dörner, Leonie Schulze-Hagen, Andreas Müller, Marius Wilsing, Jan-Malte Sinning, Julian Lütkens, Christian Frerker, Karl-Heinz Kuck, Ingo Gräff, Hans Schild, Nikos Werner, Eberhard Grube, Georg Nickenig
AIMS: To date every post-procedural cerebrovascular embolic event (CVE) is dreaded for its potential to accelerate cognitive decline after transcatheter aortic valve implantation (TAVI). This study differentiates the impact of acute (procedural) and post-acute cerebrovascular embolic events (CVEs) on cognitive performance. METHODS: Magnetic resonance imaging (MRI) before, early and late after TAVI was performed to quantify embolic burden. Quantification of diffusion- and T1-weighted lesions, as well as white-matter and total brain volumes, as well as cognitive function testing (MMSE) were assessed in 28 patients with a medium follow-up period of 34 months...
2017: PloS One
https://www.readbyqxmd.com/read/28054834/long-term-restrictions-in-participation-in-stroke-survivors-under-and-over-70-years-of-age
#13
Joris A de Graaf, Maria L van Mierlo, Marcel W M Post, Wilco P Achterberg, L Jaap Kappelle, Johanna M A Visser-Meily
PURPOSE: This study aims to (1) assess differences in participation restrictions between stroke survivors aged under and over 70 years and (2) identify predictors associated with favorable and unfavorable long-term participation in both age groups. METHODS: Prospective cohort study in which 326 patients were assessed at stroke onset, two months and one year after stroke. The Utrecht Scale for Evaluation of Rehabilitation-Participation (USER-Participation) was used to measure participation restrictions one year after stroke...
January 5, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28049565/adapting-the-concepts-of-brain-and-cognitive-reserve-to-post-stroke-cognitive-deficits-implications-for-understanding-neglect
#14
Roza M Umarova
Advanced lesion mapping and connectivity analyses are currently the main tools used to understand the mechanisms underlying post-stroke cognitive deficits. However, the factors contributing to pre-stroke architecture of cognitive networks are often ignored, even though they reportedly play a decisive role in the manifestation of cognitive impairment in neurodegeneration. The present review on post-stroke cognitive deficits therefore adopts the concept of brain and cognitive reserve, which was originally developed to account for the individual differences in the course of aging and neurodegenerative diseases...
December 16, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28041574/suicidal-ideation-at-1-year-post-stroke-a-nationwide-survey-in-china
#15
Yang Yang, Yu-Zhi Shi, Ning Zhang, Shuo Wang, Gabor S Ungvari, Chee H Ng, Yi-Long Wang, Xing-Quan Zhao, Yong-Jun Wang, Chun-Xue Wang, Yu-Tao Xiang
OBJECTIVE: Few studies on suicidal ideation have been conducted in post-stroke patients in China. This national study examined suicidal ideation at 1-year post-stroke and explored its demographic and clinical correlates. METHODS: A total of 1418 patients with ischemic stroke were included in 56 hospitals nationwide. Demographic, clinical characteristics and neuro-imaging information were collected with standardized instruments, including assessment of stroke severity, depression, cognitive impairment, stroke recurrence, physical disability and insomnia...
January 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28000998/the-role-of-objective-cognitive-dysfunction-in-subjective-cognitive-complaints-after-stroke
#16
M W A van Rijsbergen, R E Mark, W J Kop, P L M de Kort, M M Sitskoorn
BACKGROUND AND PURPOSE: Objective cognitive performance (OCP) is often impaired in patients post-stroke but the consequences of OCP for patient-reported subjective cognitive complaints (SCC) are poorly understood. We performed a detailed analysis on the association between post-stroke OCP and SCC. METHODS: Assessments of OCP and SCC were obtained in 208 patients 3 months after stroke. OCP was evaluated using conventional and ecologically valid neuropsychological tests...
December 21, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27999490/predictors-for-post-stroke-delirium-outcome
#17
Zikrija Dostovic, Ernestina Dostovic, Dzevdet Smajlovic, Omer C Ibrahimagic, Leila Avdic, Elvir Becirovic
BACKGROUND: There have been only a small number of studies that have evaluated the outcome of post-stroke delirium. OBJECTIVES: To evaluate the effects of gender, age, stroke localization, delirium severity, previous illnesses, associated medical complications on delirium outcome as well as, to determine effects of delirium on cognitive functioning one year after stroke. PATIENTS AND METHODS: Comprehensive neuropsychological assessments were performed within the first week of stroke onset, at hospital discharge, and followed-up for 3, 6 and 12 months after stroke...
October 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/27974998/assessment-of-cognitive-and-neurologic-recovery-in-ischemic-stroke-drug-trials-results-from-a-randomized-double-blind-placebo-controlled-study
#18
Franco Di Cesare, Jessica Mancuso, Brian Silver, Peter T Loudon
Objective. Ischemic stroke is a serious medical condition with limited therapeutic options. The evaluation of the therapeutic potential of novel pharmacological interventions is carried-out in Phase II trials. The study design, primarily intended to evaluate efficacy and safety, is a balance between utilizing as few patients as possible to minimize safety risk and enrolling sufficient patients to detect unambiguous efficacy signals. We sought to determine whether post-stroke recovery outcomes based on behavioral measures of cognitive and motor impairment yielded additional information beyond that of clinician-based methods...
September 2016: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/27966299/cognitive-impairment-one-year-after-ischemic-stroke-predictorsand-dynamics-of-significant-determinants
#19
Margarita Lubomirova Alexandrova, Maya Penkova Danovska
BACKGROUND/AIM: Evidence suggests that the risk for dementia increases after stroke. This study investigated the dynamics of the neurological and cognitive status of patients with no baseline dementia over a 1-year period after ischemic stroke. MATERIALS AND METHODS: We examined 47 ischemic stroke patients admitted within 48 h of ictus. Their neurological and cognitive statuses, blood biochemical parameters, and microalbuminuria levels were prospectively evaluated over a 1-year period post-stroke...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27938433/deep-microbleeds-and-periventricular-white-matter-disintegrity-are-independent-predictors-of-attention-executive-dysfunction-in-non-dementia-patients-with-small-vessel-disease
#20
Wen-Wei Cao, Yao Wang, Quan Dong, Xue Chen, Yan-Sheng Li, Yan Zhou, Li Gao, Ye Deng, Qun Xu
BACKGROUND: Cerebral small vessel disease (SVD) is the common cause of cognitive decline in the old population. MRI can be used to clarify its mechanisms. However, the surrogate markers of MRI for early cognitive impairment in SVD remain uncertain to date. We investigated the cognitive impacts of cerebral microbleeds (CMBs), diffusion tensor imaging (DTI), and brain volumetric measurements in a cohort of post-stroke non-dementia SVD patients. METHODS: Fifty five non-dementia SVD patients were consecutively recruited and categorized into two groups as no cognitive impairment (NCI) (n = 23) or vascular mild cognitive impairment (VaMCI) (n = 32)...
December 12, 2016: International Psychogeriatrics
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