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Post-stroke cognitive impairment

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https://www.readbyqxmd.com/read/29907385/long-term-changes-in-cerebrovascular-reactivity-following-ec-ic-bypass-for-intracranial-steno-occlusive-disease
#1
Casey Rosen, Larissa McKetton, Jeremy Russell, Kevin Sam, Julien Poublanc, Adrian Crawley, Jay S Han, Olivia Sobczyk, James Duffin, Danny M Mandell, Michael Tymianski, Joseph A Fisher, David J Mikulis, Lashmi Venkatraghavan
The purpose of this retrospective observational study is to investigate the long-term changes in cerebrovascular reactivity (CVR) as a measure of cerebral hemodynamics in patients with intracranial steno-occlusive disease (IC-SOD) after they have undergone an Extracranial-intracranial (EC-IC) bypass. Twenty-six patients suffering from IC-SOD were selected from our CVR database. Nineteen patients underwent unilateral and 7 underwent bilateral revascularization. CVR measurements were done using BOLD-MRI and precisely controlled CO2 and expressed as ΔBOLD (%)/Δ PET CO2 (mmHg)...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29879031/the-association-of-different-types-of-cerebral-infarction-with-post-stroke-depression-and-cognitive-impairment
#2
Jun Tu, Ling-Xiao Wang, Hong-Feng Wen, Yi-Cheng Xu, Pei-Fu Wang
The aim of this study was to investigate post-stroke depression (PSD) and cognitive impairments in patients with different types of cerebral infarction.A total of 110 patients with cerebral infarction treated in our hospital from January 2015 to February 2016 were included in present study. Forty-seven patients were PSD patients and 63 patients were non-PSD patients. The Hamilton Depression Rating Scale (HAMD) and Mini-Mental State Examination (MMSE) were employed to assess depression and cognition of patientsAmong PSD patients, the proportion of patients with partial anterior circulation infarction (PACI, 68...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29867570/xinnao-shutong-modulates-the-neuronal-plasticity-through-regulation-of-microglia-macrophage-polarization-following-chronic-cerebral-hypoperfusion-in-rats
#3
Liye Wang, Rongliang Wang, Zhigang Chen, Haiping Zhao, Yumin Luo
Xinnao shutong (XNST) capsules have been clinically used in China to treat cerebrovascular diseases. Previous studies have demonstrated that XNST has significant neuroprotective effects against acute cerebral ischemic stroke. The present study investigated the effects and mechanisms of XNST treatment following chronic cerebral hypoperfusion. Thirty-six adult male Sprague-Dawley rats were treated with XNST or vehicle following permanent bilateral common carotid artery (BCCA) ligation. Body weight was recorded on days 0, 3, 7, 14, 28, and 42 post-surgery...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29863688/-the-prognosis-for-post-stroke-aphasia
#4
V V Alferova, V M Shklovskij, E G Ivanova, G V Ivanov, L A Mayorova, A G Petrushevsky, S V Kuptsova, A B Guekht
AIM: To determine risk factors and factors of favorable prognosis for regression of post-stroke aphasia in the early recovery period of ischemic stroke (IS). MATERIAL AND METHODS: A cohort study was undertaken with 40 patients with different clinical forms of aphasia. The duration of study was 3-4 months of the disease. The regression of speech and non-speech cognitive impairment was assessed by the Method of a 10-point evaluation of higher mental functions. The method involves a comprehensive assessment of all mental functions with more than 90 subtests at the beginning and at the end of rehabilitation course and the calculation of the difference in the scoring of each mental function as a measure of treatment efficacy...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29843688/huatuo-zaizao-pill-ameliorates-cognitive-impairment-of-app-ps1-transgenic-mice-by-improving-synaptic-plasticity-and-reducing-a%C3%AE-deposition
#5
Jing-Hua Zhang, Lin-Jie Yu, Hui Yang, Zhen Hui, Su Jiang, Ling Chen, Yang Zhao, Su-Lei Wang, Yi Liu, Yun Xu
BACKGROUND: It is well known that Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and synaptic dysfunction play important roles in the pathophysiology of Alzheimer's disease (AD). The Huatuo Zaizao pill (HT) is a Traditional Chinese Medicine (TCM) that has been used clinically for many years in China, mainly for post-stroke rehabilitation and cognitive decline; however, the mechanism of cognitive function is not clear...
May 29, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29803601/cognitive-impairment-vulnerability-and-mortality-post-ischemic-stroke-a-five-year-follow-up-of-the-action-on-secondary-prevention-interventions-and-rehabilitation-in-stroke-aspire-s-cohort
#6
Eva Gaynor, Daniela Rohde, Margaret Large, Lisa Mellon, Patricia Hall, Linda Brewer, Orla Conway, Anne Hickey, Kathleen Bennett, Eamon Dolan, Elizabeth Callaly, David Williams
BACKGROUND: The aim of this study was to examine predictors of mortality in patients 5 years after ischemic stroke, focusing on cognitive impairment, vulnerability, and vascular risk factors assessed at 6 months post stroke. MATERIALS AND METHODS: Patients from the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) cohort were followed up 5 years post ischemic stroke. Vascular risk factors, cognitive impairment, and vulnerability were assessed at 6 months post stroke...
May 23, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29798978/-the-relationship-of-pathological-ankle-brachial-index-and-cognitive-decline-in-patients-after-ischemic-stroke
#7
Yu A Kolmykova, I N Kukhareva, M V Ott, O A Trubnikova, A V Kovalenko, A N Sumin
AIM: To identify associations between cognitive impairment and values of ankle-brachial index (ABI) in patients after ischemic stroke at discharge from the hospital and over one-year follow-up. MATERIAL AND METHODS: The study included 375 patients with normal (n=192) and elevated (n=153) ABI who underwent ischemic stroke (IS). Neurological examination was performed using NIHSS, the Rankin scale, Barthel index, Rivermead Mobility Index at discharge from the hospital and over one-year follow-up...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29793824/effects-of-glycemic-variability-and-hyperglycemia-in-acute-ischemic-stroke-on-post-stroke-cognitive-impairments
#8
Jae-Sung Lim, Chulho Kim, Mi Sun Oh, Ju-Hun Lee, San Jung, Min Uk Jang, Sang-Hwa Lee, Yeo Jin Kim, Yerim Kim, Sang Won Suh, Byung-Chul Lee, Kyung-Ho Yu
AIMS: We aimed to investigate the effect of glycemic variability in the acute stage of stroke on the development of post-stroke cognitive impairment (PSCI). METHODS: Patients who underwent blood glucose tests at least five times within 7 days after acute ischemic stroke were included. Factors related to glycemic variability (standard deviation (SD), coefficient of variance (CV), and mean absolute glucose (MAG)) were calculated; neuropsychological assessments were administered 3 months after stroke...
March 29, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29765301/the-additional-contribution-of-white-matter-hyperintensity-location-to-post-stroke-cognitive-impairment-insights-from-a-multiple-lesion-symptom-mapping-study
#9
Lei Zhao, Adrian Wong, Yishan Luo, Wenyan Liu, Winnie W C Chu, Jill M Abrigo, Ryan K L Lee, Vincent Mok, Lin Shi
White matter hyperintensities (WMH) are common in acute ischemic stroke patients. Although WMH volume has been reported to influence post-stroke cognition, it is still not clear whether WMH location, independent of acute ischemic lesion (AIL) volume and location, contributes to cognitive impairment after stroke. Here, we proposed a multiple-lesion symptom mapping model that considers both the presence of WMH and AIL to measure the additional contribution of WMH locations to post-stroke cognitive impairment...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29740308/cyclosporin-a-mediated-activation-of-endogenous-neural-precursor-cells-promotes-cognitive-recovery-in-a-mouse-model-of-stroke
#10
Labeeba Nusrat, Jessica M Livingston-Thomas, Vaakiny Raguthevan, Kelsey Adams, Ilan Vonderwalde, Dale Corbett, Cindi M Morshead
Cognitive dysfunction following stroke significantly impacts quality of life and functional independance; yet, despite the prevalence and negative impact of cognitive deficits, post-stroke interventions almost exclusively target motor impairments. As a result, current treatment options are limited in their ability to promote post-stroke cognitive recovery. Cyclosporin A (CsA) has been previously shown to improve post-stroke functional recovery of sensorimotor deficits. Interestingly, CsA is a commonly used immunosuppressant and also acts directly on endogenous neural precursor cells (NPCs) in the neurogenic regions of the brain (the periventricular region and the dentate gyrus)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29712605/long-term-functional-outcomes-after-blunt-cerebrovascular-injury-a-20-year-experience
#11
Charles P Shahan, Taylor C Stavely, Martin A Croce, Timothy C Fabian, Louis J Magnotti
Since blunt cerebrovascular injury (BCVI) became increasingly recognized more than 20 years ago, significant improvements have been made in both diagnosis and treatment. Little is known regarding long-term functional outcomes in BCVI. The purpose of this study was to evaluate the impact of BCVI on those long-term outcomes. All patients with BCVI from 1996 to 2014 were identified from the trauma registry. Functional outcome was measured using the Boston University Activity Measure for Post-Acute Care. Multiple regression analysis was performed to identify potential predictors of outcomes...
April 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29712538/the-relationship-between-early-post-stroke-cognition-and-longer-term-activities-and-participation-a-systematic-review
#12
Joseph A Mole, Nele Demeyere
This systematic review examined whether early cognitive impairment after stroke is predictive of outcome within the "activity" and "participation" domains of the International Classification of Functioning, Disability and Health (ICF) at 6-12 months post-injury. Studies were included if cognitive functioning was assessed within 6 weeks of injury and outcome was measured at least 6 months post-injury. PsycINFO, MEDLINE, CINAHL and EMBASE databases were searched and 14 studies were identified...
April 30, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29685145/post-stroke-unilateral-spatial-neglect-virtual-reality-based-navigation-and-detection-tasks-reveal-lateralized-and-non-lateralized-deficits-in-tasks-of-varying-perceptual-and-cognitive-demands
#13
Tatiana Ogourtsova, Philippe S Archambault, Anouk Lamontagne
BACKGROUND: Unilateral spatial neglect (USN), a highly prevalent and disabling post-stroke impairment, has been shown to affect the recovery of locomotor and navigation skills needed for community mobility. We recently found that USN alters goal-directed locomotion in conditions of different cognitive/perceptual demands. However, sensorimotor post-stroke dysfunction (e.g. decreased walking speed) could have influenced the results. Analogous to a previously used goal-directed locomotor paradigm, a seated, joystick-driven navigation experiment, minimizing locomotor demands, was employed in individuals with and without post-stroke USN (USN+ and USN-, respectively) and healthy controls (HC)...
April 23, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29684474/environmental-enrichment-cognitive-neuroprotection-in-an-experimental-model-of-cerebral-ischemia-biochemical-and-molecular-aspects
#14
Lara Vezula Gonçalves, Alice Laschuk Herlinger, Tamara Andrea Alarcon Ferreira, Juliana Barbosa Coitinho, Rita Gomes Wanderley Pires, Cristina Martins-Silva
Stroke is considered a major cause of global morbidity. Currently, there are no effective treatments for post-stroke cognitive impairment. Enriched environment (EE) has been brought forward as a preconditioning method to induce cerebral tolerance in an ischemic event. However, the subjacent mechanisms involved in this tolerance are not yet clear. Herein we aimed to identify the mechanisms of neuroprotection triggered by EE preconditioning in a murine model of ischemic stroke. In order to do so, C57Bl/6 mice were kept for five weeks either in EE or in standard environment (SC) prior to ischemic injury through bilateral carotid occlusion (BCCAo) or sham surgery...
August 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29680773/changes-in-the-hippocampal-and-peripheral-phospholipid-profiles-are-associated-with-neurodegeneration-hallmarks-in-a-long-term-global-cerebral-ischemia-model-attenuation-by-linalool
#15
Angélica Maria Sabogal-Guáqueta, Rafael Posada-Duque, Natalie Charlotte Cortes, Julian D Arias-Londoño, Gloria Patricia Cardona-Gómez
Phospholipid alterations in the brain are associated with progressive neurodegeneration and cognitive impairment after acute and chronic injuries. Various types of treatments have been evaluated for their abilities to block the progression of the impairment, but effective treatments targeting long-term post-stroke alterations are not available. In this study, we analyzed changes in the central and peripheral phospholipid profiles in ischemic rats and determined whether a protective monoterpene, Linalool, could modify them...
June 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29678195/does-sensorimotor-upper-limb-therapy-post-stroke-alter-behavior-and-brain-connectivity-differently-compared-to-motor-therapy-protocol-of-a-phase-ii-randomized-controlled-trial
#16
Nele De Bruyn, Bea Essers, Liselot Thijs, Annick Van Gils, Lisa Tedesco Triccas, Sarah Meyer, Kaat Alaerts, Geert Verheyden
BACKGROUND: The role of somatosensory feedback in motor performance has been warranted in the literature. Although sensorimotor deficits are common after stroke, current rehabilitation approaches primarily focus on restoring upper limb motor ability. Evidence for integrative sensorimotor rehabilitation approaches is scarce, as is knowledge about neural correlates of somatosensory impairments after stroke and the effect of rehabilitation on brain connectivity level. Therefore, we aim to investigate changes in sensorimotor function and brain connectivity following a sensorimotor therapy program compared to an attention-matched motor therapy program for the upper limb after stroke...
April 20, 2018: Trials
https://www.readbyqxmd.com/read/29660413/validation-of-french-upper-limb-erasmus-modified-nottingham-sensory-assessment-in-stroke
#17
Claire Villepinte, Emilie Catella, Magali Martin, Sylvie Hidalgo, Sabrina Téchené, Claire Lebely, Evelyne Castel-Lacanal, Xavier de Boissezon, HuiJun Chih, David Gasq
BACKGROUND: Somatosensory impairment of the upper limb (UL) occurs in approximately 50% of adults post-stroke, associated with loss of hand motor function, activity and participation. Measurement of UL sensory impairment is a component of rehabilitation contributing to the selection of sensorimotor techniques optimizing recovery and providing a prognostic estimate of UL function. To date, no standardized official French version of a measure of somatosensory impairment has been established...
April 13, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29648983/enhancement-of-brain-d-serine-mediates-recovery-of-cognitive-function-after-traumatic-brain-injury
#18
Sigal Liraz-Zaltsman, Barbara Slusher, Dana Atrakchi-Baranes, Kineret Rosenblatt, Yael Friedman Levi, Efrat Kesner, Alcino J Silva, Anat Biegon, Esther Shohami
Cognitive deficits, especially memory loss, are common and devastating neuropsychiatric sequelae of traumatic brain injury (TBI). The deficits may persist for years and may be accompanied by increased risk of developing early- onset dementia. Past attempts to reverse the neuropathological effects of brain injury with glutamate-N-methyl-d-aspartate (NMDA) antagonists failed to show any benefits or worsened the outcome, suggesting that activation, rather than blockage, of the NMDA receptor (NMDAR) may be useful in the subacute period after TBI and stroke...
April 30, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29617168/what-neuropsychological-functions-best-discriminate-performance-in-adults-post-stroke
#19
Jaqueline de Carvalho Rodrigues, Wagner de Lara Machado, Denise Ren da Fontoura, Andrea Garcia Almeida, Rosane Brondani, Sheila Ouriques Martins, Denise Ruschel Bandeira, Jerusa Fumagalli de Salles
This study aimed to develop a short version of an instrument to detect cognitive impairment in stroke patients, investigate which cognitive dimensions best discriminate between stroke patients and healthy adults and to graphically analyze the relationships among the neuropsychological variables and groups. This pilot study included 94 adults (49 post-stroke and 45 neurologically healthy) who answered the Brief Neuropsychological Assessment Battery NEUPSILIN for patients with expressive aphasia (NEUPSILIN-Af) to assess orientation, perception, memory, praxis, executive functions, oral language, and academic achievement (written language and arithmetic)...
April 4, 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29610037/cytokine-response-tract-specific-fractional-anisotropy-and-brain-morphometry-in-post-stroke-cognitive-impairment
#20
Aleksey Kulesh, Viktor Drobakha, Elena Kuklina, Irina Nekrasova, Vladimir Shestakov
BACKGROUND: Post-stroke cognitive impairment is a clinically heterogeneous condition and its types have a different course and prognosis. The aim of the present study is to address the roles of inflammation, white matter pathology, and brain atrophy in different neuropsychological types of cognitive impairment in the acute period of ischemic stroke. METHODS: In 92 patients, we performed an assessment of the cognitive status and measured concentrations of cytokines (interleukin [IL]-1β, IL-6, tumor necrosis factor-alpha, IL-10) in liquor and serum, as well as a number of magnetic resonance imaging (MRI) morphometric parameters and fractional anisotropy...
July 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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