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Post-stroke cognitive impairment

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https://www.readbyqxmd.com/read/29660413/validation-of-french-upper-limb-erasmus-modified-nottingham-sensory-assessment-in-stroke
#1
Claire Villepinte, Emilie Catella, Magali Martin, Sylvie Hidalgo, Sabrina Téchené, Claire Lebely, Evelyne Castel-Lacanal, Xavier de Boissezon, HuiJun Chih, David Gasq
BACKGROUND: Somatosensory impairment of the upper limb (UL) occurs in approximately 50% of adults post-stroke, associated with loss of hand motor function, activity and participation. Measurement of UL sensory impairment is a component of rehabilitation contributing to the selection of sensorimotor techniques optimising recovery and providing a prognostic estimate of UL function. To date, no standardized official French version of a measure of somatosensory impairment has been established...
April 13, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29648983/enhancement-of-brain-d-serine-mediates-recovery-of-cognitive-function-after-tbi
#2
Sigal Liraz-Zaltsman, Barbara Slusher, Dana Atrakchi-Baranes, Kinneret Rosenblatt, Yael Friedman Levi, Efrat Leah Kesner, Alcino J Silva, Anat Biegon, Esther Shohami
Cognitive deficits, especially memory loss, are common and devastating neuropsychiatric sequelae of traumatic brain injury (TBI). The deficits may persist for a long time and may be accompanied by increased risk of developing early onset dementia. Past attempts to reverse the neuropsychological effects of brain injury with glutamate-N-methyl-D-aspartate (NMDA) antagonists failed to show any benefits or worsened the outcome, suggesting activation, rather than blockage, of the NMDA receptor (NMDAR) may be useful in the sub-acute period after TBI and stroke...
March 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29617168/what-neuropsychological-functions-best-discriminate-performance-in-adults-post-stroke
#3
Jaqueline de Carvalho Rodrigues, Wagner de Lara Machado, Denise Ren da Fontoura, Andrea Garcia Almeida, Rosane Brondani, Sheila Ouriques Martins, Denise Ruschel Bandeira, Jerusa Fumagalli de Salles
This study aimed to develop a short version of an instrument to detect cognitive impairment in stroke patients, investigate which cognitive dimensions best discriminate between stroke patients and healthy adults and to graphically analyze the relationships among the neuropsychological variables and groups. This pilot study included 94 adults (49 post-stroke and 45 neurologically healthy) who answered the Brief Neuropsychological Assessment Battery NEUPSILIN for patients with expressive aphasia (NEUPSILIN-Af) to assess orientation, perception, memory, praxis, executive functions, oral language, and academic achievement (written language and arithmetic)...
April 4, 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29610037/cytokine-response-tract-specific-fractional-anisotropy-and-brain-morphometry-in-post-stroke-cognitive-impairment
#4
Aleksey Kulesh, Viktor Drobakha, Elena Kuklina, Irina Nekrasova, Vladimir Shestakov
BACKGROUND: Post-stroke cognitive impairment is a clinically heterogeneous condition and its types have a different course and prognosis. The aim of the present study is to address the roles of inflammation, white matter pathology, and brain atrophy in different neuropsychological types of cognitive impairment in the acute period of ischemic stroke. METHODS: In 92 patients, we performed an assessment of the cognitive status and measured concentrations of cytokines (interleukin [IL]-1β, IL-6, tumor necrosis factor-alpha, IL-10) in liquor and serum, as well as a number of magnetic resonance imaging (MRI) morphometric parameters and fractional anisotropy...
March 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29569040/recurrent-hypoglycemia-exacerbates-cerebral-ischemic-damage-in-diabetic-rats-via-enhanced-post-ischemic-mitochondrial-dysfunction
#5
Vibha Shukla, Perry Fuchs, Allen Liu, Charles H Cohan, Chuanhui Dong, Clinton B Wright, Miguel A Perez-Pinzon, Kunjan R Dave
Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function has been implicated as a central player in the development of cerebral ischemic damage. Hypoglycemia is also known to affect mitochondrial functioning. The present study tested the hypothesis that prior exposure of insulin-treated diabetic (ITD) rats to RH exacerbates brain damage via enhanced post-ischemic mitochondrial dysfunction...
March 22, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29541055/using-the-oxford-cognitive-screen-to-detect-cognitive-impairment-in-stroke-patients-a-comparison-with-the-mini-mental-state-examination
#6
Mauro Mancuso, Nele Demeyere, Laura Abbruzzese, Alessio Damora, Valentina Varalta, Fabio Pirrotta, Gabriella Antonucci, Alessandro Matano, Marina Caputo, Maria Giovanna Caruso, Giovanna Teresa Pontiggia, Michela Coccia, Irene Ciancarelli, Pierluigi Zoccolotti
Background: The Oxford Cognitive Screen (OCS) was recently developed with the aim of describing the cognitive deficits after stroke. The scale consists of 10 tasks encompassing five cognitive domains: attention and executive function, language, memory, number processing, and praxis. OCS was devised to be inclusive and un-confounded by aphasia and neglect. As such, it may have a greater potential to be informative on stroke cognitive deficits of widely used instruments, such as the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment, which were originally devised for demented patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29487561/a-case-control-study-investigating-simulated-driving-errors-in-ischemic-stroke-and-subarachnoid-hemorrhage
#7
Megan A Hird, Kristin A Vesely, Tahira Tasneem, Gustavo Saposnik, R Loch Macdonald, Tom A Schweizer
Background: Stroke can affect a variety of cognitive, perceptual, and motor abilities that are important for safe driving. Results of studies assessing post-stroke driving ability are quite variable in the areas and degree of driving impairment among patients. This highlights the need to consider clinical characteristics, including stroke subtype, when assessing driving performance. Methods: We compared the simulated driving performance of 30 chronic stroke patients (>3 months), including 15 patients with ischemic stroke (IS) and 15 patients with subarachnoid hemorrhage (SAH), and 20 age-matched controls...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29451096/elevated-crp-at-admission-predicts-post-stroke-cognitive-impairment-in-han-chinese-patients-with-intracranial-arterial-stenosis
#8
Jian Guo, Wei Su, Jinhuan Fang, Ning Chen, Muke Zhou, Yang Zhang, Li He
OBJECTIVES: Elevated C-reactive protein (CRP) levels have been associated with cognitive deficits in certain patient populations, but whether this is also true of ischemic stroke patients is controversial. This study aims to examine the possible association between CRP concentration and post-stroke cognitive impairment (PSCI) in Han Chinese patients and to determine whether this association depends on intracranial arterial stenosis (ICAS). METHODS: Patients with mild or moderate stroke admitted to a large regional medical center in Western China were consecutively enrolled in our study...
April 2018: Neurological Research
https://www.readbyqxmd.com/read/29448162/cognitive-motor-dual-task-interference-modulates-mediolateral-dynamic-stability-during-gait-in-post-stroke-individuals
#9
R Tisserand, S Armand, G Allali, A Schnider, S Baillieul
Gait asymmetry and dynamic balance impairments observed in post-stroke individuals increase their risk of fall. Moreover, walking while performing a cognitive task (i.e. dual-task) disturbs the control of balance in post-stroke individuals. Here we investigated the mediolateral dynamic stability in twenty-two community-dwelling participants (12 post-strokes and 10 healthy controls) while walking in single-task (normal gait) and four different dual-tasks (cognitive-motor interference). Positions of the extrapolated center of mass and mediolateral widths of both margin of stability and base of support were extracted from 35 marker trajectories...
February 12, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29427575/rhythm-perception-and-production-abilities-and-their-relationship-to-gait-after-stroke
#10
Kara K Patterson, Jennifer S Wong, Svetlana Knorr, Jessica A Grahn
OBJECTIVES: To assess rhythm abilities, describe their relationship to clinical presentation, and to determine if rhythm production independently contributes to temporal gait asymmetry post-stroke. DESIGN: Cross-sectional. SETTING: Large urban rehabilitation hospital and university. PARTICIPANTS: Individuals with subacute and chronic stroke (n=39) and data for healthy adults extracted from a pre-existing database (n=21)...
February 7, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29427168/diagnostic-test-accuracy-of-the-montreal-cognitive-assessment-in-the-detection-of-post-stroke-cognitive-impairment-under-different-stages-and-cutoffs-a-systematic-review-and-meta-analysis
#11
Dan Shi, Xiao Chen, Zheng Li
The purposes of this review were to give the optimal cutoffs of the Montreal Cognitive Assessment (MoCA) by comparing sensitivity and specificity under different cutoffs and compare the MoCA with other screening tools in post-stroke cognitive impairment (PSCI) determined by a neuropsychological evaluation. Articles were derived from a systematic search in PubMed, Web of science, Embase, and CINAHL and were assessed for internal validity by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The figure of risk of bias was made by Review Manager 5...
February 9, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29423616/frequency-and-predictors-of-post-stroke-delirium-in-prospective-observational-polish-study-propolis
#12
P Pasinska, K Kowalska, E Klimiec, A Szyper-Maciejowska, A Wilk, A Klimkowicz-Mrowiec
Delirium is the most common and serious neurobehavioral complication in acute hospital admissions. Some patients develop signs of delirium but do not meet all diagnostic criteria. Stroke is a major risk factor for delirium. The aim of this prospective study was to build a predictive model for delirium and subsyndromal post-stroke delirium. Patients with stroke were screened for delirium during the first 7 days after admission. Delirium was diagnosed according to DSM-V criteria. Baseline demographic, biochemical, stroke-related data, medications used, neurological deficit, and premorbid cognitive and functional impairment were assessed...
February 8, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29409115/expression-of-nerve-growth-factor-carried-by-pseudotyped-lentivirus-improves-neuron-survival-and-cognitive-functional-recovery-of-post-ischemia-in-rats
#13
Jia-Yu Cao, Yong Lin, Yan-Fei Han, Sheng-Hao Ding, Yi-Ling Fan, Yao-Hua Pan, Bing Zhao, Qin-Hua Guo, Wen-Hua Sun, Jie-Qing Wan, Xiao-Ping Tong
AIMS: Nerve growth factor (NGF) has been reported to prevent neuronal damage and contributes to the functional recovery in animal brain injury models and human ischemic disease as well. We aimed to investigate a potential therapeutic effect of NGF gene treatment in ischemic stroke and to estimate the functional recovery both at the cellular and cognitive levels in an ischemia rat model. METHODS: After microinjection of pseudolentivirus-delivered β-NGF into an established ischemic stroke model in rats (tMCAO), we estimated neuronal cell apoptosis with TUNEL labeling and neurogenesis by cell proliferation marker Ki67 staining in both ischemic core and penumbra of striatum...
February 6, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29406402/impaired-cognitive-performance-in-endothelial-nitric-oxide-synthase-knock-out-mice-after-ischemic-stroke-a-pilot-study
#14
Shanshan Li, Yao Wang, Ze Jiang, Yaping Huai, James K Liao, Kaari A Lynch, Ross Zafonte, Lisa J Wood, Qing Mei Wang
OBJECTIVES: Cognitive dysfunction and dementia are common following ischemic stroke. Endothelial nitric oxide synthase (eNOS) has been found to play an important role in neurological function and cognition. The purpose of the present study was to assess the specific role of eNOS in cognitive performance after stroke. DESIGN: Male wildtype (WT) and mice lacking eNOS (eNOS) underwent middle cerebral artery occlusion (MCAO) or sham-surgery. Primary outcomes were repeated measures of neurological score, limb asymmetry, sensory/motor function and spatial memory/learning assessed at intervals up to 28-days post-surgery...
February 5, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29372883/brain-repair-by-hematopoietic-growth-factors-in-the-subacute-phase-of-traumatic-brain-injury
#15
Gentian Toshkezi, Michele Kyle, Sharon L Longo, Lawrence S Chin, Li-Ru Zhao
OBJECTIVE Traumatic brain injury (TBI) is a major cause of long-term disability and death in young adults. The lack of pharmaceutical therapy for post-acute TBI recovery remains a crucial medical challenge. Stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF), which are 2 key hematopoietic growth factors, have shown neuroprotective and neurorestorative effects in experimental stroke. The objective of this study was to determine the therapeutic efficacy of combined treatment (SCF + G-CSF) in subacute TBI...
January 26, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29354984/-electroacupuncture-for-post-stroke-cognitive-impairment-a-systematic-review-and-meta-analyses
#16
Jie Zhan, Xuewen Wang, Nanfang Cheng, Feng Tan
OBJECTIVE: To systematically evaluate the efficacy and safety of electroacupuncture (EA) for post stroke cognitive impairment (PSCI). METHODS: The randomized clinical trials (RCTs) regarding EA for PSCI published before October of 2016 were researched in China National Knowledge Infrastructure (CNKI), Chinese Biomedical Database (CBM), WanFang database, VIP medicine information system, PubMed and Cochrane Library. The literature screening and information extraction was conducted by two independent reviewers...
October 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29354218/evolution-of-short-cognitive-test-performance-in-stroke-patients-with-vascular-cognitive-impairment-and-vascular-dementia-baseline-evaluation-and-follow-up
#17
Nilton Custodio, Rosa Montesinos, David Lira, Eder Herrera-Perez, Yadira Bardales, Lucia Valeriano-Lorenzo
There is limited evidence about the progression of cognitive performance during the post-stroke stage. Objective: To assess the evolution of cognitive performance in stroke patients without vascular cognitive impairment (VCI), patients with vascular mild cognitive impairment (MCI), and patients with vascular dementia (VD). Methods: A prospective cohort of stroke outpatients from two secondary medical centers in Lima, Peru was studied. We performed standardized evaluations at definitive diagnosis (baseline evaluation), and control follow-ups at 6 and 12 months, including a battery of short cognitive tests: Clinical Dementia Rating (CDR), Addenbrooke's Cognitive Examination (ACE), and INECO Frontal Screening (IFS)...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29338817/correlation-of-stress-hyperglycemia-after-ischemic-stroke-with-early-vascular-cognitive-impairment
#18
Yi Dong Zhou, Huai Wu Yuan, Ren Jie Ji, Ben Yan Luo
Objective To investigate the influence and forecast value of stress hyperglycemia on the early vascular cognitive impairment (VCI) in stroke patients.Methods Totally 422 patients with acute non-diabetic stroke were divided into three groups according to the fasting plasma glucose level:the euglycemia group (<6.1 mmol/L),the mild stress hyperglycemia group (6.1-7.0 mmol/L),and the severe stress hyperglycemia group (≥7.0 mmol/L).Mini-mental state examination,Alzheimer's disease rating scale cognitive subscale,and clinical dementia rating scale were used to evaluate early cognition in post-stroke patients,and patients were divided into three groups accordingly:normal cognitive function group,mild VCI group,and vascular dementia group...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29334331/transport-mobility-5-years-after-stroke-in-an-urban-setting
#19
Hanna C Persson, Helena Selander
Background People after stroke may have residual problems with mobility that can affect their independence and mode of transport. However, there is limited knowledge about transport mobility several years after stroke. Objective The objective was to survey the outdoor mobility and transportation in an urban setting five years post-stroke. Method This cross-sectional study was based on a mail survey focusing on long-term consequences after stroke. The survey comprises a set of self-evaluated questionnaires and was sent to 457 persons, of whom 281 responded (61...
April 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29325929/post-stroke-cognitive-impairment-depression-and-apathy-untangling-the-relationship
#20
EDITORIAL
Perminder S Sachdev
No abstract text is available yet for this article.
March 2018: American Journal of Geriatric Psychiatry
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