Read by QxMD icon Read

Post-stroke cognitive impairment

Roderick Wondergem, Martijn F Pisters, Eveline J Wouters, Nick Olthof, Rob A de Bie, Johanna M A Visser-Meily, Cindy Veenhof
BACKGROUND: Stroke is not only an acute disease, but for the majority of patients, it also becomes a chronic condition. There is a major concern about the long-term follow-up with respect to activities of daily living (ADL) in stroke survivors. Some patients seem to be at risk for decline after a first-ever stroke. The purpose of this study was to determine the course of ADL from 3 months after the first-ever stroke and onward and identify factors associated with decline in ADL. METHODS: A systematic literature search of 3 electronic databases through June 2015 was conducted...
October 18, 2016: Cerebrovascular Diseases
Teige C Bourke, Catherine R Lowrey, Sean P Dukelow, Stephen D Bagg, Kathleen E Norman, Stephen H Scott
BACKGROUND: Stroke can affect our ability to perform daily activities, although it can be difficult to identify the underlying functional impairment(s). Recent theories highlight the importance of sensory feedback in selecting future motor actions. This selection process can involve multiple processes to achieve a behavioural goal, including selective attention, feature/object recognition, and movement inhibition. These functions are often impaired after stroke, but existing clinical measures tend to explore these processes in isolation and without time constraints...
October 10, 2016: Journal of Neuroengineering and Rehabilitation
Xiaoyan Jiang, Hongjian Pu, Xiaoming Hu, Zhishuo Wei, Dandan Hong, Wenting Zhang, Yanqin Gao, Jun Chen, Yejie Shi
White matter injury induced by ischemic stroke elicits sensorimotor impairments, which can be further deteriorated by persistent proinflammatory responses. We previously reported that delayed and repeated treatments with omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve spatial cognitive functions and hippocampal integrity after ischemic stroke. In the present study, we report a post-stroke n-3 PUFA therapeutic regimen that not only confers protection against neuronal loss in the gray matter but also promotes white matter integrity...
December 2016: Translational Stroke Research
Andoret van Wyk, Carina A Eksteen, Piet J Becker, Barbara M Heinze
INTRODUCTION: Visual impairment, specifically eye movement disorders and vestibular dysfunction may have a negative influence on the functional recovery in post-stroke patients. This type of sensory dysfunction may further be associated with poor functional outcome in patients' post-stroke. METHODS: In phase 1, a cross-sectional survey (n = 100) will be conducted to determine the prevalence of eye movement disorders and vestibular dysfunction in patients who sustained a stroke...
2016: Frontiers in Neurology
Siham Zahi, Laila Mahir, Herman Azanmasso, Fatima Lmidmani, Abdellatif El Fatimi
OBJECTIVE: Depression affects many people following their stroke (between 30 and 60%). It can occur in the days following the attack but several years later. Our objective was to investigate the incidence of depression and anxiety in our patients after stroke followed for post-stroke hemiplegia. MATERIAL/PATIENTS AND METHODS: Prospective study over 6 months from 10 September 2014 to 10 March 2015. It covered all cases of stroke supported the MPR service during this period were excluded patients with severe aphasia...
September 2016: Annals of Physical and Rehabilitation Medicine
Bertrand Glize, Étienne Santos, Sophie Broussy, Igor Sibon, Pierre-Alain Joseph, Patrick Dehail
OBJECTIVE: Post-stroke medical management, defined by national and international guidelines, involves many professionals, allowing optimal secondary prevention. The general practitioner is as a major player in this management. The improved of this management appears as the new challenge following the stroke Plan 2009-2014. The aim of this study was to evaluate the medical and paramedical management of patients in the year following a stroke. MATERIAL/PATIENTS AND METHODS: This was an observational study among general practitioners of stroke patients in Aquitaine...
September 2016: Annals of Physical and Rehabilitation Medicine
Flavia Coroian, Jérôme Froger, H-Y Bonnin Koang, Claire Jourdan, Karima Bakhti, Marc Julia, Audrey Jaussent, Christian Hérisson, Isabelle Laffont
OBJECTIVE: The sensori-motor impairment of upper limb (UL) affects more than 50% of patients after stroke. The objective of this work was to study the efficiency of isokinetic muscle strengthening (IMS) in the chronic phase of stroke in this population. MATERIAL/PATIENTS AND METHODS: The patients underwent 6 weeks of outpatient rehabilitation, 3 days per week, combining physiotherapy (twice/day) and occupational therapy every day. The program was completed by 30 minutes elbow and wrist concentric slow speed IMS of flexor and extensor muscles, in the study group versus 30 minutes passive mobilisation of the joints carried out by the same isokinetic dynamometer in the control group...
September 2016: Annals of Physical and Rehabilitation Medicine
Mathilde Chevignard, Camille de Montferrand, Estelle Yvon-Chaou, Alain Mardaye, Anne Tiberghien, Anne Laurent-Vannier, Georges Dellatolas
OBJECTIVE: Studies on language outcome following childhood stroke are rare. The aims of this study were to study language, cognitive and school outcomes following childhood stroke. MATERIALS/PATIENTS AND METHODS: We retrospectively reviewed the files of children (1 month-15 years) consecutively admitted to a physical medicine and rehabilitation department following childhood stroke between 1992 and 2015. Age at onset, aetiology, lesion laterality, initial severity, motor and functional impairments upon admission and discharge, language tests, neuropsychological assessment (or developmental age/quotient) and academic outcome were collected...
September 2016: Annals of Physical and Rehabilitation Medicine
Sébastien Baillieul, Dominic Perennou, Mathieu Marillier, Jean-Louis Pépin, Samuel Vergès, Bernard Wuyam
OBJECTIVE: Obstructive sleep apnea (OSA) is now widely seen as a major public health issue with widespread societal consequences. In addition to an increased stroke risk, OSA leads to cerebral consequences including cognitive deficits that impair quality of life and daily functioning. In a recent uncontrolled study, moderate-to-severe OSA have been associated with higher stride time variability (STV), reflecting poor gait control (Celle, Annweiler et al., 2014). STV is a clinical marker of cortical gait control linked with cognitive performance and cerebral integrity (Beauchet, Annweiler et al...
September 2016: Annals of Physical and Rehabilitation Medicine
N Charfi, S Trabelsi, M Turki, M Mâalej Bouali, L Zouari, M Dammak, J Ben Thabet, C Mhiri, M Mâalej
INTRODUCTION: The physical and/or psycho-cognitive changes after stroke may lead to a decline in the quality of life (QOL) of patients. The aims of our study were to evaluate the QOL of stroke survivors and to investigate its relationships with the physical disability degree and the emotional disorders (anxiety and depression). METHODS: We conducted a cross-sectional study, which included 147 patients, followed for stroke that had occurred over the past year, in the outpatient neurology department at the university hospital Habib Bourguiba of Sfax (Tunisia)...
September 20, 2016: L'Encéphale
Xin Wang, Aiguo Chen, Honghai Wu, Min Ye, Hong Cheng, Xinfeng Jiang, Xiaohong Wang, Xiaobin Zhang, Di Wu, Xin Gu, Feiyang Shen, Chunlei Shan, Duonan Yu
Post-stroke cognitive impairment (PSCI), commonly seen in the clinical practice, is a major factor impeding patient rehabilitation. Enriched environment (EE) intervention is a simple and effective way to improve cognitive impairment, partially due to the rebalancing of the basal forebrain-hippocampus cholinergic signaling pathway. Epigenetic changes have been identified in many cognitive disorders. However, studies on the effects of EE on epigenetic regulation of cholinergic circuits in PSCI animal models have not yet been reported...
November 1, 2016: Brain Research
Adrian Wong, Alexander Y L Lau, Jie Yang, Zhaolu Wang, Wenyan Liu, Bonnie Y K Lam, Lisa Au, Lin Shi, Defeng Wang, Winnie C W Chu, Yun-Yun Xiong, Eugene S K Lo, Lorraine S N Law, Thomas W H Leung, Linda C W Lam, Anne Y Y Chan, Yannie O Y Soo, Eric Y L Leung, Lawrence K S Wong, Vincent C T Mok
BACKGROUND: The objectives of this study are 1) to examine the frequencies of neuropsychiatric symptom clusters in patients with stroke or transient ischemic attack (TIA) by cognitive level and stroke subtype; and 2) to evaluate effect of demographic, clinical, and neuroimaging measures of chronic brain changes and amyloid upon neuropsychiatric symptom clusters. METHODS: Hospital-based, cross-sectional study. 518 patients were administered the Neuropsychiatric Inventory (NPI) 3-6 months post index admission...
2016: PloS One
Nia M Harris, Rodney Ritzel, Nikolas Mancini, Yuhang Jiang, Xiang Yi, Devika S Manickam, William A Banks, Alexander V Kabanov, Louise D McCullough, Rajkumar Verma
BACKGROUND: Low levels of brain-derived neurotrophic factor (BDNF) are linked to delayed neurological recovery, depression, and cognitive impairment following stroke. Supplementation with BDNF reverses these effects. Unfortunately, systemically administered BDNF in its native form has minimal therapeutic value due to its poor blood brain barrier permeability and short serum half-life. In this study, a novel nano-particle polyion complex formulation of BDNF (nano-BDNF) was administered to mice after experimental ischemic stroke...
September 13, 2016: Pharmacology, Biochemistry, and Behavior
T S Klarić, E J Jaehne, S A Koblar, B T Baune, M D Lewis
In addition to causing widespread cell death and loss of brain function, cerebral ischaemia also induces extensive neuroplasticity. In humans, stroke is often accompanied by severe cognitive and psychiatric changes that are thought to arise as a consequence of this infarct-induced remodelling. A candidate for producing these post-stroke neuropsychiatric changes is Npas4, an activity-dependent transcription factor involved in synaptic plasticity whose expression is aberrantly up-regulated following ischaemic injury...
January 1, 2017: Behavioural Brain Research
Celine Timmermans, Melvyn Roerdink, Marielle W van Ooijen, Carel G Meskers, Thomas W Janssen, Peter J Beek
BACKGROUND: Walking in everyday life requires the ability to adapt walking to the environment. This adaptability is often impaired after stroke, and this might contribute to the increased fall risk after stroke. To improve safe community ambulation, walking adaptability training might be beneficial after stroke. This study is designed to compare the effects of two interventions for improving walking speed and walking adaptability: treadmill-based C-Mill therapy (therapy with augmented reality) and the overground FALLS program (a conventional therapy program)...
2016: Trials
Mohd Faizal Mohd Zulkifly, Shazli Ezzat Ghazali, Normah Che Din, Ponnusamy Subramaniam
BACKGROUND: This study aims to estimate the prevalence and explore the predictors for post-stroke cognitive impairment at the community level in Malaysia. METHODS: A total of 50 stroke patients aged 29 to 81-year-old were included in this study. A face to face interview was conducted to gather the demographic and clinical data. Subsequently, assessments including Barthel ADL Index (BI), Addenbrooke's Cognitive Examination-Revised (ACE-R) and Hospital Anxiety and Depression Scale (HADS) were administered to the subjects...
March 2016: Malaysian Journal of Medical Sciences: MJMS
Francesco Arba, Terence J Quinn, Graeme J Hankey, Kennedy R Lees, Joanna M Wardlaw, Myzoon Ali, Domenico Inzitari
BACKGROUND: Previous studies suggested that enlarged perivascular spaces are neuroimaging markers of cerebral small vessel disease. However, it is not clear whether enlarged perivascular spaces are associated with cognitive impairment. We aimed to determine the cross-sectional relationship between enlarged perivascular spaces and small vessel disease, and to investigate the relationship between enlarged perivascular spaces and subsequent cognitive impairment in patients with recent cerebral ischemic event...
August 19, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Frank Arne Wollenweber, Sonja Därr, Claudia Müller, Marco Duering, Katharina Buerger, Vera Zietemann, Rainer Malik, Matthias Brendel, Birgit Ertl-Wagner, Peter Bartenstein, Axel Rominger, Martin Dichgans
BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) is common after stroke and associated with poor outcome. However, the mechanisms underlying poststroke MCI (PS-MCI) are insufficiently understood. We performed amyloid-β positron emission tomography (PET) in a prospective cohort of stroke survivors to determine the role of amyloid pathology in PS-MCI. METHODS: We studied 178 consecutive patients enrolled into the prospective DEDEMAS study (Determinants of Dementia After Stroke)...
October 2016: Stroke; a Journal of Cerebral Circulation
Kristian P Doyle, Marion S Buckwalter
Post-stroke cognitive decline and dementia pose a significant public health problem, with 30% of stroke survivors suffering from dementia. The reason for this high prevalence is not well understood. Pathogenic B cell responses to the damaged CNS are one possible contributing factor. B-lymphocytes and antibodies are present in and around the stroke core of some human subjects who die with stroke and dementia, and mice that develop delayed cognitive dysfunction after stroke have clusters of B-lymphocytes in the stroke lesion, and antibody infiltration in the stroked hemisphere...
August 13, 2016: Brain, Behavior, and Immunity
Matthias Volz, Johanna Möbus, Christa Letsch, Katja Werheid
BACKGROUND: Post-stroke depression (PSD) is the most frequent mental disorder after stroke, affecting about 30% of stroke survivors. Despite extensive research, little is known about the influence of general self-efficacy (GSE) on PSD. We investigated the effect of GSE on depression six months post-stroke while controlling for established risk factors. METHODS: Eighty-eight patients from two rehabilitation centers with first-ever ischemic stroke were assessed around 8 weeks and 6 months after stroke...
July 22, 2016: Journal of Affective Disorders
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"