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Post-stroke cognitive impairment

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https://www.readbyqxmd.com/read/29022422/investigating-cognitive-ability-and-self-reported-driving-performance-of-post-stroke-adults-in-a-driving-simulator
#1
Alison Blane, Torbjörn Falkmer, Hoe C Lee, Tania Dukic Willstrand
Background Safe driving is a complex activity that requires calibration. This means the driver can accurately assess the level of task demand required for task completion and can accurately evaluate their driving capability. There is much debate on the calibration ability of post-stroke drivers. Objectives The aim of this study was to assess the cognition, self-rated performance, and estimation of task demand in a driving simulator with post-stroke drivers and controls. Methods A between-groups study design was employed, which included a post-stroke driver group and a group of similarly aged older control drivers...
October 12, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29022086/lesions-responsible-for-delayed-oral-transit-time-in-post-stroke-dysphagia
#2
Hyun Im Moon, Seo Yeon Yoon, Tae Im Yi, Yoon Jeong Jeong, Tae Hwan Cho
INTRODUCTION: Some stroke patients show oral phase dysphagia, characterized by a markedly prolonged oral transit time that hinders oral feeding. The aim of this study was to clarify the clinical characteristics and lesions responsible for delayed swallowing. METHODS: We reviewed 90 patients with stroke. The oral processing time plus the postfaucial aggregation time required to swallow semisolid food was assessed. The patients were divided into two groups according to oral transit time, and we analyzed the differences in characteristics such as demographic factors, lesion factors, and cognitive function...
October 11, 2017: Dysphagia
https://www.readbyqxmd.com/read/29020466/improving-post-stroke-cognitive-and-behavioral-abnormalities-by-using-virtual-reality-a-case-report-on-a-novel-use-of-nirvana
#3
Rosaria De Luca, Michele Torrisi, Adriana Piccolo, Giovanni Bonfiglio, Provvidenza Tomasello, Antonino Naro, Rocco Salvatore Calabrò
Cognitive impairment, as well as mood and anxiety disorders, occur frequently in patients following stroke. Aim of this study was to evaluate the effects of a combined rehabilitative treatment using conventional relaxation and respiratory techniques, in a specific rehabilitative virtual environment (by using Bts-Nirvana). A 58-year-old woman, affected by hemorrhagic stroke, underwent two different rehabilitation trainings, including either standard relaxation techniques alone in a common clinical setting or the same psychological approach in a semi-immersive virtual environment with an augmented sensorial (audio-video) and motor feedback (sensory motor-interaction)...
October 11, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29017492/electroacupuncture-ameliorating-post-stroke-cognitive-impairments-via-inhibition-of-peri-infarct-astroglial-and-microglial-macrophage-p2-purinoceptors-mediated-neuroinflammation-and-hyperplasia
#4
Jia Huang, Xiaofang You, Weilin Liu, Changming Song, Xiaomin Lin, Xiufeng Zhang, Jing Tao, Lidian Chen
BACKGROUND: During ischemic stroke (IS), adenosine 5'-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors singling, and causing pro-inflammatory cytokine secretion, which is likely to initiate or aggravate motor and cognitive impairment. It has been proved that electroacupuncture (EA) is an effective and safe strategy used in anti-inflammation. However, EA for the role of purine receptors in the central nervous system has not yet been reported...
October 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28993004/cerebral-amyloid-angiopathy-related-cognitive-impairment-the-search-for-a-specific-neuropsychological-pattern
#5
REVIEW
M Planton, N Raposo, J-F Albucher, J Pariente
Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage. CAA can also be diagnosed in memory clinics when patients are referred for cognitive impairment assessment, and may be a reason for admission to emergency or neurology departments because of rapidly progressive cognitive or neurological decline, or a transient focal neurological episode. CAA may even be observed in older community-dwelling individuals. Neuropsychological impairment in CAA has been described over the past 20 years...
October 6, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28980579/-a-comparative-clinical-study-of-the-efficacy-of-computer-cognitive-training-in-patients-with-post-stroke-cognitive-impairments
#6
S V Prokopenko, A F Bezdenezhnykh, E Yu Mozheyko, E M Zubrickaya
AIM: To assess the effectiveness of neuropsychological computer programs in comparison with entertainment computer games. MATERIAL AND METHODS: Patients (n=68), aged 40-65 years, were randomized into three groups: an intervention group (neuropsychological computer programs), an active control group (entertaining computer games), a passive control group (conventional treatment). RESULTS: An analysis of the coefficient of effectiveness showed significant improvements in the intervention group comparing with the passive control group (MoCA, MMSE, Schulte test) and the active control group (MoCA)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28970969/slower-eeg-alpha-generation-synchronization-and-flow-possible-biomarkers-of-cognitive-impairment-and-neuropathology-of-minor-stroke
#7
Jelena Petrovic, Vuk Milosevic, Miroslava Zivkovic, Dragan Stojanov, Olga Milojkovic, Aleksandar Kalauzi, Jasna Saponjic
BACKGROUND: We investigated EEG rhythms, particularly alpha activity, and their relationship to post-stroke neuropathology and cognitive functions in the subacute and chronic stages of minor strokes. METHODS: We included 10 patients with right middle cerebral artery (MCA) ischemic strokes and 11 healthy controls. All the assessments of stroke patients were done both in the subacute and chronic stages. Neurological impairment was measured using the National Institute of Health Stroke Scale (NIHSS), whereas cognitive functions were assessed using the Montreal Cognitive Assessment (MoCA) and MoCA memory index (MoCA-MIS)...
2017: PeerJ
https://www.readbyqxmd.com/read/28963553/development-and-validation-of-a-risk-score-change-for-cognitive-impairment-after-ischemic-stroke
#8
Russell J Chander, Bonnie Y K Lam, Xuling Lin, Aloysius Y T Ng, Adrian P L Wong, Vincent C T Mok, Nagaendran Kandiah
Post-stroke cognitive impairment (PSCI) warrants early detection and management. We sought to develop a risk score for screening patients at bedside for risk of delayed PSCI. Ischemic stroke survivors with PSCI and no cognitive impairments (NCI) 3-6 months post-stroke were studied to identify candidate variables predictive of PSCI. These variables were used to develop a risk score using regression models. The score, and the best identified clinical cutoff point, underwent development, stability testing, and internal and external validation in three independent cohorts from Singapore and Hong Kong...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28963037/disruption-of-the-ascending-arousal-system-and-cortical-attention-networks-in-post-stroke-delirium-and-spatial-neglect
#9
REVIEW
Olga Boukrina, A M Barrett
Delirium is an acute attention and cognitive dysfunction, adversely affecting functional outcomes and mortality. As many as half of hospitalized right brain stroke survivors may develop delirium. Further, about 50% of right stroke patients experience spatial neglect, impairing safety and recovery. In this review we explore the brain mechanisms, which may explain the high incidence of delirium and spatial neglect after right-brain stroke. We suggest that brain networks for spatial attention and arousal, composed of ascending projections from the midbrain nuclei and integrating dorsal and ventral cortical and limbic components, may underlie impairments in delirium and spatial neglect...
September 27, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28962104/altered-functional-connectivity-in-patients-with-post-stroke-memory-impairment-a-resting-fmri-study
#10
Jiao Liu, Qin Wang, Feiwen Liu, Haiyan Song, Xiaofeng Liang, Zhengkun Lin, Wenjun Hong, Shanli Yang, Jia Huang, Guohua Zheng, Jing Tao, Li-Dian Chen
Post-stroke memory dysfunction (PMD) is one of the most common forms of cognitive impairment among stroke survivors. However, only a limited number of studies have directly investigated the neural mechanisms associated with memory decline. The aim of the present study was to identify dynamic changes in the functional organization of the default mode network (DMN) and the dorsal attention network of patients with PMD. A total of 27 patients with PMD who experienced a stroke in the right hemisphere were enrolled in the current study, along with 27 healthy control subjects matched by age, sex, and educational level...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28942450/cognitive-function-and-prognosis-of-multimodal-neuroimage-guided-thrombectomy-on-mild-to-moderate-anterior-circulation-infarction-patients-with-broadened-therapeutic-window-a-prospective-study
#11
Guodong Xu, Xiaoli Dong, Xiaoli Niu, Guimin Zheng, Hebo Wang, Fan Zhang, Litao Li, Peiyuan Lv
BACKGROUND AND OBJECTIVES: Endovascular mechanical thrombectomy is an important approach for acute ischemic stroke (AIS) treatment. Multimodal neuroimaging methods ideally provide the exact localization, extent, and metabolic activity of target tissues. Post-stroke cognitive impairment has recently been realized to be another major concern except for neurological function impairment. The aim of our study was to carry out a prospective study to compare neurological and cognitive functions after thrombectomy in mild to moderate anterior circulation infarction patients selected by multimodal neuroimaging...
September 22, 2017: European Neurology
https://www.readbyqxmd.com/read/28924104/validation-of-the-r2chads2-and-chads2-scores-for-predicting-post-stroke-cognitive-impairment
#12
Kazuo Washida, Hisatomo Kowa, Hirotoshi Hamaguchi, Fumio Kanda, Tatsushi Toda
Objective Post-stroke cognitive impairment often afflicts stroke survivors and is a major obstacle both for cognitive and physical rehabilitation. Stroke risk scores ["Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, Stroke" (CHADS2) and "CHADS2 + creatinine clearance <60 mL/min" (R2CHADS2)] are used to assess the future risk of cardioembolic stroke in patients with atrial fibrillation (AF). However, congestive heart failure, hypertension, aging, diabetes mellitus, stroke, and renal dysfunction are also risk factors for cognitive impairment...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28922154/atrial-fibrillation-is-independently-associated-with-cognitive-impairment-after-ischemic-stroke
#13
Russell Jude Chander, Levinia Lim, Sagarika Handa, Shaun Hiu, Angeline Choong, Xuling Lin, Rajinder Singh, Daniel Oh, Nagaendran Kandiah
BACKGROUND: While atrial fibrillation (AF) is an important risk factor for ischemic strokes and mild cognitive impairment (MCI) in Alzheimer's disease, the association between AF and post-stroke cognitive impairment (PSCI), and the factors mediating this association, is unclear. OBJECTIVE: To investigate the role of AF in PSCI, especially in relation to other markers of cerebrovascular disease. METHODS: 445 subjects with mild ischemic stroke without pre-stroke cognitive decline were assessed 3-6 months post-stroke for cognitive deficits...
September 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28895445/strategic-infarct-location-for-post-stroke-cognitive-impairment-a-multivariate-lesion-symptom-mapping-study
#14
Lei Zhao, J Matthijs Biesbroek, Lin Shi, Wenyan Liu, Hugo J Kuijf, Winnie Wc Chu, Jill M Abrigo, Ryan Kl Lee, Thomas Wh Leung, Alexander Yl Lau, Geert J Biessels, Vincent Mok, Adrian Wong
Lesion location is an important determinant for post-stroke cognitive impairment. Although several 'strategic' brain regions have previously been identified, a comprehensive map of strategic brain regions for post-stroke cognitive impairment is lacking due to limitations in sample size and methodology. We aimed to determine strategic brain regions for post-stroke cognitive impairment by applying multivariate lesion-symptom mapping in a large cohort of 410 acute ischemic stroke patients. Montreal Cognitive Assessment at three to six months after stroke was used to assess global cognitive functioning and cognitive domains (memory, language, attention, executive and visuospatial function)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28886738/gaps-in-care-for-patients-with-memory-deficits-after-stroke-views-of-healthcare-providers
#15
Eugene Yee Hing Tang, Christopher Price, Blossom Christa Maree Stephan, Louise Robinson, Catherine Exley
BACKGROUND: Stroke is a common cause of physical disability but is also strongly associated with cognitive impairment and a risk for future dementia. Despite national clinical guidelines, the service provided for stroke survivors with cognitive and memory difficulties varies across localities. This study critically evaluated the views of healthcare professionals about barriers and facilitators to their care. METHODS: Seventeen semi-structured individual interviews were conducted by a single interviewer with both primary and secondary care clinicians in regular contact with stroke-survivors...
September 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28884386/association-between-cardiac-autonomic-control-and-cognitive-performance-among-patients-post-stroke-and-age-matched-healthy-controls-an-exploratory-pilot-study
#16
Noa Raphaely Beer, Nachum Soroker, Nathan M Bornstein, Michal Katz Leurer
Associations between autonomic nervous system health and cognitive performance have been described in different populations. Autonomic disturbances are a common phenomenon in patients post stroke. Little is known about the relationship between post stroke disturbances of the autonomic nervous system and the commonly occurring disturbances of cognitive functions revealed by victims of stroke. To assess the association between heart rate variability (HRV) and cognitive performance among patients post ischemic stroke and healthy age-matched controls, 13 patients post first-ever ischemic stroke aged 40-80 years and 15 age-matched healthy controls were evaluated...
September 7, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28881795/rnase-alleviates-neurological-dysfunction-in-mice-undergoing-cardiac-arrest-and-cardiopulmonary-resuscitation
#17
Ye Ma, Chan Chen, Shu Zhang, Qiao Wang, Hai Chen, Yuanlin Dong, Zheng Zhang, Yan Li, Zhendong Niu, Tao Zhu, Hai Yu, Bin Liu
Cardiac arrest (CA) is one of the leading lethal factors. Despite cardiopulmonary resuscitation (CPR) procedure has been consecutively improved and lots of new strategies have been developed, neurological outcome of the patients experienced CPR is still disappointing. Ribonuclease (RNase) has been demonstrated to have neuroprotective effects in acute stroke and postoperative cognitive impairment, possibly through acting against endogenous RNA that released from damaged tissue. However, the role of RNase in post-cardiac arrest cerebral injury is unknown...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28842715/high-serum-levels-of-malondialdehyde-and-8-ohdg-are-both-associated-with-early-cognitive-impairment-in-patients-with-acute-ischaemic-stroke
#18
Zhihua Liu, Yuntao Liu, Xinjie Tu, Huiping Shen, Huihua Qiu, Huijun Chen, Jincai He
Post-stroke cognitive impairment (PSCI) is an increasingly prevalent sequel after stroke that may associate with poor functional outcome and increased risk of recurrent stroke. We aimed to explore the relationship between oxidative stress biomarkers and the presence of PSCI. 193 first-ever acute ischaemic stroke patients were consecutively enrolled in the current study. The oxidative stress biomarkers malondialdehyde (MDA) and 8-hydroxydeoxyquanosine (8-OHdG) were measured within 24 h after admission. Cognition function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after stroke...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838792/vascular-cognitive-impairment-advances-and-trends
#19
REVIEW
M Barbay, H Taillia, C Nedelec-Ciceri, A Arnoux, L Puy, E Wiener, S Canaple, C Lamy, O Godefroy, M Roussel
The presence of vascular neurocognitive impairment (whatever the severity) is always associated with a functional impact and increased risk of dependency and institutionalization. However, vascular cognitive impairment remains underdiagnosed, and the mechanisms underlying post-stroke cognitive disorders are still poorly understood. However, the advent of new criteria and a standardized international neuropsychological battery is expected to lead to improved diagnosis and management, and the development of novel techniques (such as brain imaging and amyloid PET) should improve our understanding of the mechanisms underlying vascular cognitive impairment and help to identify potential targets for therapy...
August 21, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28821706/apigenin-ameliorates-post-stroke-cognitive-deficits-in-rats-through-histone-acetylation-mediated-neurochemical-alterations
#20
Fengxia Tu, Qiongyi Pang, Tingting Huang, Yun Zhao, Meixia Liu, Xiang Chen
BACKGROUND To identify the effect of apigenin on cognitive deficits of rats after cerebral ischemia and reperfusion injury, and to investigate the potential molecular mechanisms. MATERIAL AND METHODS The rats were given sodium butyrate (NaB) or apigenin (20 or 40 mg/kg) for 28 days. Cognition was investigated by the Morris water maze (MWM) test. On day 28, the rats were euthanized and their hippocampal brain regions were used to identify biochemical and neurochemical alterations. The content of histone deacetylase (HDAC) was measured by enzyme-linked immunosorbent assay (ELISA)...
August 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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