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https://www.readbyqxmd.com/read/29021196/nf-%C3%AE%C2%BAb-dependent-upregulation-of-pro-renin-receptor-mediates-high-nacl-induced-apoptosis-in-mouse-inner-medullary-collecting-duct-cells
#1
Jiahui Su, Xiyang Liu, Chuanming Xu, Xiaohan Lu, Fei Wang, Hui Fang, Aihua Lu, Qixiang Qiu, Chunling Li, Tianxin Yang
(Pro)renin receptor (PRR), a new component of renin-angiotensin system (RAS), has emerged as a new regulator of collecting duct function. The present study was designed to investigate the role of PRR in high salt-induced apoptosis in cultured mouse inner medullary collecting duct cells, mIMCD-K2 cells. Exposure to high NaCl at 550 mOsm/kg H2O increased PRR protein abundance so did mannitol, sodium gluconate or choline chloride. This was accompanied with upregulation of phosphorylated NF-κB p65 protein abundance...
October 11, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29019944/variation-and-distribution-of-l-a-helper-totiviruses-in-saccharomyces-sensu-stricto-yeasts-producing-different-killer-toxins
#2
Nieves Rodríguez-Cousiño, Pilar Gómez, Rosa Esteban
Yeasts within the Saccharomyces sensu stricto cluster can produce different killer toxins. Each toxin is encoded by a medium size (1.5-2.4 Kb) M dsRNA virus, maintained by a larger helper virus generally called L-A (4.6 Kb). Different types of L-A are found associated to specific Ms: L-A in K1 strains and L-A-2 in K2 strains. Here, we extend the analysis of L-A helper viruses to yeasts other than S. cerevisiae, namely S. paradoxus, S. uvarum and S. kudriavzevii. Our sequencing data from nine new L-A variants confirm the specific association of each toxin-producing M and its helper virus, suggesting co-evolution...
October 11, 2017: Toxins
https://www.readbyqxmd.com/read/29019496/mechanochemically-prepared-srfcl-nanophosphor-co-doped-with-yb-3-and-er-3-for-detecting-ionizing-radiation-by-upconversion-luminescence
#3
Jun Zhang, Nicolas Riesen, Hans Riesen
We report a novel method for detecting ionizing radiation by employing the phenomenon of upconversion luminescence. Nanocrystalline SrFCl:Yb(3+)/Er(3+) was prepared by ball-milling and characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The photoluminescence properties of nanocrystalline SrFCl:Yb(3+), SrFCl:Er(3+) and SrFCl:Yb(3+)/Er(3+) before and after X-irradiation were investigated. The results demonstrate that both Yb(3+) and Er(3+) ions in the SrFCl host are reduced to their divalent state upon X-ray exposure...
October 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/29016659/effectiveness-of-longitudinal-faculty-development-programs-on-mcqs-items-writing-skills-a-follow-up-study
#4
Hamza Mohammad Abdulghani, Mohammad Irshad, Shafiul Haque, Tauseef Ahmad, Kamran Sattar, Mahmoud Salah Khalil
This study examines the long-term impact of the faculty development programs on the multiple choice question (MCQ) items' quality leading to study its effect on the students' overall competency level during their yearly academic assessment. A series of longitudinal highly constructed faculty development workshops were conducted to improve the quality of the MCQs items writing skills. A total of 2207 MCQs were constructed by 58 participants for the assessment of 882 students' cognitive competency level during the academic years 2012-2015...
2017: PloS One
https://www.readbyqxmd.com/read/28988127/comparative-genome-analysis-of-novel-podoviruses-lytic-for-hypermucoviscous-klebsiella-pneumoniae-of-k1-k2-and-k57-capsular-types
#5
Ekaterina V Solovieva, Vera P Myakinina, Angelina A Kislichkina, Valentina M Krasilnikova, Vladimir V Verevkin, Vladimir V Mochalov, Anastasia I Lev, Nadezhda K Fursova, Nikolay V Volozhantsev
Hypermucoviscous (HV) strains of capsular types K1, K2 and K57 are the most virulent representatives of the Klebsiella pneumoniae species. Eight novel bacteriophages lytic for HV K. pneumoniae were isolated and characterized. Three bacteriophages, KpV41, KpV475, and KpV71 were found to have a lytic activity against mainly K. pneumoniae of capsular type K1. Two phages, KpV74, and KpV763 were lytic for K2 capsular type K. pneumoniae, and the phage KpV767 was specific to K57-type K. pneumoniae only. Two more phages, KpV766, and KpV48 had no capsular specificity...
October 5, 2017: Virus Research
https://www.readbyqxmd.com/read/28987091/experimental-and-theoretical-studies-of-the-reactions-of-ground-state-sulfur-atoms-with-hydrogen-and-deuterium
#6
Kristopher M Thompson, Yide Gao, Paul Marshall, Han Wang, Linsen Zhou, Yongle Li, Hua Guo
The gas-phase kinetics of S((3)P) atoms with H2 and D2 have been studied via the laser flash photolysis-resonance fluorescence technique. S atoms were generated by pulsed photolysis of CS2 at 193 nm and monitored by time-resolved fluorescence at 181 nm. The rate coefficients for H2 (k1) and D2 (k2), respectively, are summarized as k1(600-1110 K) = 3.0 × 10(-9) exp-1.317×10(5)-2.703×10(7)K/T8.314 T/K cm(3) molecule(-1) s(-1) and k2(770-1110 K) = 2.2 × 10(-14) (T/298 K)(3.55) exp(-5420 K/T) cm(3) molecule(-1) s(-1)...
October 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28986748/anesthetic-isoflurane-or-desflurane-plus-surgery-differently-affects-cognitive-function-in-alzheimer-s-disease-transgenic-mice
#7
Huihui Miao, Yuanlin Dong, Yiying Zhang, Hui Zheng, Yuan Shen, Gregory Crosby, Deborah J Culley, Edward R Marcantonio, Zhongcong Xie
Anesthesia/surgery could be associated with cognitive impairment and Alzheimer's disease neuropathogenesis. However, whether surgery under different anesthetics has different effects on cognitive function remains largely unknown. We therefore set out to compare effects of anesthetic isoflurane or desflurane plus surgery on cognitive function and hippocampus levels of synaptic marker (postsynaptic density-95 and synaptophysin) and ATP. Five-month-old AD Transgenic (Tg) (FAD5X) and wild-type male mice received isoflurane or desflurane plus abdominal surgery...
October 6, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28984839/complete-mitochondrial-genome-sequencing-of-a-burial-from-a-romano-christian-cemetery-in-the-dakhleh-oasis-egypt-preliminary-indications
#8
J Eldon Molto, Odile Loreille, Elizabeth K Mallott, Ripan S Malhi, Spence Fast, Jennifer Daniels-Higginbotham, Charla Marshall, Ryan Parr
The curse of ancient Egyptian DNA was lifted by a recent study which sequenced the mitochondrial genomes (mtGenome) of 90 ancient Egyptians from the archaeological site of Abusir el-Meleq. Surprisingly, these ancient inhabitants were more closely related to those from the Near East than to contemporary Egyptians. It has been accepted that the timeless highway of the Nile River seeded Egypt with African genetic influence, well before pre-Dynastic times. Here we report on the successful recovery and analysis of the complete mtGenome from a burial recovered from a remote Romano-Christian cemetery, Kellis 2 (K2)...
October 6, 2017: Genes
https://www.readbyqxmd.com/read/28973555/the-effects-of-an-environmentally-relevant-level-of-arsenic-on-the-gut-microbiome-and-its-functional-metagenome
#9
Liang Chi, Xiaoming Bian, Bei Gao, Pengcheng Tu, Hongyu Ru, Kun Lu
Multiple environmental factors induce dysbiosis in the gut microbiome and cause a variety of human diseases. Previously, we have first demonstrated that arsenic alters the composition of the gut microbiome. However, the functional impact of arsenic on the gut microbiome has not been adequately assessed, particularly at environmentally relevant concentrations. In this study, we used 16S rRNA sequencing and metagenomics sequencing to investigate how exposure to 100 ppb arsenic for 13 weeks alters the composition and functional capacity of the gut microbiome in mice...
August 29, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28967756/low-ph-induced-lamellar-to-bicontinuous-primitive-cubic-phase-transition-in-dioleoylphosphatidylserine-monoolein-membranes
#10
Toshihiko Oka, Moynul Hasan, Md Zahidul Islam, Md Moniruzzaman, Masahito Yamazaki
Electrostatic interactions (EIs) play important roles in the structure and stability of inverse bicontinuous cubic (QII) phases of lipid membranes. We examined the effect of pH on the phase of dioleoylphosphatidylserine (DOPS)/monoolein (MO) membranes at low ionic strengths using small-angle X-ray scattering (SAXS). We found that the phase transitions from lamellar liquid-crystalline (Lα) to primitive cubic (QII(P)) phases in DOPS/MO (2/8 molar ratio) membranes occurred in buffers containing 50 mM NaCl at and below the final pH of 2...
October 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28960496/synthesis-and-functional-investigations-of-computer-designed-novel-cladribine-like-compounds-for-the-treatment-of-multiple-sclerosis
#11
Serkan Yavuz, Aysu Çetin, Atilla Akdemir, Doğukan Doyduk, Ali Dişli, Gurbet Çelik Turgut, Alaattin Şen, Yılmaz Yıldırır
Cladribine (2-CdA) is used as an anti-cancer drug but is currently studied as a potential treatment for use in relapsing-remitting multiple sclerosis (MS). In this study, we computer designed, synthesized, and characterized two novel derivatives of 2-CdA, K1-5d and K2-4c, and investigated their underlying mechanism of beneficial effect using the CCRF-CEM and RAJI cell lines. For this purpose, we first determined their effect on MS and DNA damage and repair-related gene expression profiles using custom arrays along with 2-CdA treatment at non-toxic doses...
September 28, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28952607/vitamin-k-induced-effects-on-body-fat-and-weight-results-from-a-3-year-vitamin-k2-intervention-study
#12
M H J Knapen, K M Jardon, C Vermeer
BACKGROUND/OBJECTIVES: Vitamin K status has been linked to fat and glucose metabolism by several authors, but whether high vitamin K intake influences body weight or composition has remained unclear. Here we tested the hypothesis that increased vitamin K intake decreases body fat or fat distribution. SUBJECTS/METHODS: In a randomized placebo-controlled human intervention trial, 214 postmenopausal women, 55-65 years of age, received either 180 mcg/day of vitamin K2 (menaquinone-7, MK-7) or placebo for 3 years...
September 27, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28952417/rapid-removal-of-ultra-high-concentration-p-nitrophenol-in-aqueous-solution-by-microwave-enhanced-fe-cu-bimetallic-particle-mw-fe-cu-system
#13
Yi Ren, Jinfan Zhou, Zhicheng Pan, Bo Lai, Donghai Yuan
Ultra-high-concentration PNP-contained wastewaters are produced sometimes due to the wide application of this nitrophenolic compound in the chemical industry. However, there is a lack of appropriate technologies to rapidly pretreat the ultra-high-concentration wastewater. Therefore, a new microwave-enhanced Fe/Cu bimetallic particles (MW-Fe/Cu) system was developed to rapidly remove ultra-high-concentration PNP. First, the priority of the determinative parameters was obtained by orthogonal experiment. Based on this result, the effects of initial pH, microwave power, Fe/Cu dosage and initial PNP concentration on PNP removal were optimized thoroughly...
October 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28951958/ocular-anatomic-changes-for-different-accommodative-demands-using-swept-source-optical-coherence-tomography-a-pilot-study
#14
José J Esteve-Taboada, Teresa Ferrer-Blasco, Miguel A Aloy, José E Adsuara, Pablo Cerdá-Durán, Petar Mimica, Robert Montés-Micó
PURPOSE: The purpose of our study was to assess the changes in ocular parameters for different accommodative demands using a new optical biometer based on swept-source optical coherence tomography (SS-OCT). METHODS: Seven subjects were included in this pilot study, and only one eye per participant was analyzed. Each eye was measured six times with the optical biometer IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany). As this instrument is not able to change the vergence of the stimulus, to enable measurements at different accommodative states, a tilted first-surface mirror attached to the optical biometer was used to place the fixation stimulus at different vergences...
September 26, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28951784/intrastromal-corneal-ring-segments-for-astigmatism-correction-after-deep-anterior-lamellar-keratoplasty
#15
Júlio C D Arantes, Sandro Coscarelli, Paulo Ferrara, Luana P N Araújo, Marcos Ávila, Leonardo Torquetti
Background. To evaluate the change in corneal astigmatism after intrastromal corneal ring segment (ICRS) implantation in keratoconus patients with previous deep anterior lamellar keratoplasty (DALK). Design was a longitudinal, retrospective, interventional study. The study included 25 eyes of 24 patients with keratoconus who had DALK performed at least two years prior to ICRS implantation. All patients had a clear corneal graft with up to 8.00 D of corneal astigmatism and intolerance to contact lenses. The studied parameters were age, sex, corrected distance visual acuity (CDVA), maximum keratometry (K1), minimum keratometry (K2), spherical equivalent, and astigmatism...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28942255/melamine-based-dendrimer-amine-modified-magnetic-nanoparticles-as-an-efficient-pb-ii-adsorbent-for-wastewater-treatment-adsorption-optimization-by-response-surface-methodology
#16
Fatemeh Jiryaei Sharahi, Afsaneh Shahbazi
Magnetic Fe3O4 nanoparticles with an average diameter of 64 nm was synthesized solvothermically and subsequently modified with melamine-based dendrimer amine (MDA-Fe3O4) via grafting method. The synthesized materials were characterized using DLS, SEM, XRD, FTIR, VSM, TGA and elemental analysis techniques. The MDA-Fe3O4 was employed for the efficient removal of Pb(II) ions from an aqueous solution. The adsorption efficiency was investigated in relation to the independent variables of Pb(II) concentration (80-250 mg L(-1)), pH of the solution (3-7), adsorbent dosage (0...
September 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28942247/hydrochars-and-phosphate-enhancing-the-transport-of-nanoparticle-silica-in-saturated-sands
#17
Cheng Liu, Nan Xu, Gang Feng, Dongmei Zhou, Xueying Cheng, Zuling Li
Due to the potential negative impact of nano silica (nSiO2) on human's health and living environments, it is important to investigate their transport in soil environments. Hydrochars has been widely used in agricultural soil and phosphate (P) is an important nutrient, thus the aggregation and transport of nSiO2 in saturated sand columns were investigated in single and binary systems of hydrochars and P. The experimental results showed that the nSiO2 aggregates can be restablized by the adsorption of P or the attachment of hydrochars at high IS (>100 mM) and low pH (<7...
September 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28940992/synthesis-and-characterization-of-an-eclipsed-digermylene-as-a-building-block-to-construct-a-cyclic-octagermylene
#18
Yu-Te Wey, Fan-Shan Yang, Hsien-Chen Yu, Ting-Shen Kuo, Yi-Chou Tsai
Here we report the preparation of an unprecedented Ge(I)-Ge(I) bonded digermylene [K2{Ge2(μ-κ2:η2:η4-2,6-(2,6-iPr2C6H3-N)2-4-CH3C5H2N)2}] (3) in an eclipsed conformation stabilized by two bridging diamidopyridyl ligands. Although 3 exhibits an eclipsed conformation, the Ge-Ge bond length is 2.5168(6) Å, shorter than those in the trans-bent and gauche digermylenes. In combination with two pendant amido groups, the GeI2 motif of 3 is employed as a building block to assemble the first example of octagermylene [Ge4(μ-κ2:κ1-2,6-(2,6-iPr2C6H3-N)2-4-CH3C5H2N)2]2 (5) showing a cyclic configuration and containing three distinct types of Ge(I)-Ge(I) bonds...
September 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28936426/comparison-of-diabetic-and-non-diabetic-human-leukocytic-responses-to-different-capsule-types-of-klebsiella-pneumoniae-responsible-for-causing-pyogenic-liver-abscess
#19
I Russel Lee, Ethel Sng, Kok-Onn Lee, James S Molton, Monica Chan, Shirin Kalimuddin, Ezlyn Izharuddin, David C Lye, Sophia Archuleta, Yunn-Hwen Gan
The major risk factor for Klebsiella liver abscess (KLA) is type 2 diabetes mellitus (DM), but the immunological mechanisms involved in the increased susceptibility are poorly defined. We investigated the responses of neutrophils and peripheral blood mononuclear cells (PBMCs) to hypervirulent Klebsiella pneumoniae (hvKP), the causative agent of KLA. DNA and myeloperoxidase levels were elevated in the plasma of KLA patients compared to uninfected individuals indicating neutrophil activation, but diabetic status had no effect on these neutrophil extracellular trap (NET) biomarkers in both subject groups...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28933828/latent-porosity-in-alkali-metal-m2b12f12-salts-structures-and-rapid-room-temperature-hydration-dehydration-cycles
#20
Dmitry V Peryshkov, Eric V Bukovsky, Matthew R Lacroix, Hui Wu, Wei Zhou, W Matthew Jones, Matic Lozinšek, Travis C Folsom, D Luke Heyliger, Terrence J Udovic, Steven H Strauss
Structures of the alkali-metal hydrates Li2(H2O)4Z, LiK(H2O)4Z, Na2(H2O)3Z, and Rb2(H2O)2Z, unit cell parameters for Rb2Z and Rb2(H2O)2Z, and the density functional theory (DFT)-optimized structures of K2Z, K2(H2O)2Z, Rb2Z, Rb2(H2O)2Z, Cs2Z, and Cs2(H2O)Z are reported (Z(2-) = B12F12(2-)) and compared with previously reported X-ray structures of Na2(H2O)0,4Z, K2(H2O)0,2,4Z, and Cs2(H2O)Z. Unusually rapid room-temperature hydration/dehydration cycles of several M2Z/M2(H2O)nZ salt hydrate pairs, which were studied by isothermal gravimetry, are also reported...
October 2, 2017: Inorganic Chemistry
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