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M Otre Ba, D Wrześniok, J Rok, A Beberok, E Buszman
Prochlorperazine is a phenothiazine-class antipsychotic drug usually used to treat nausea, vomiting and schizophrenia. Phenothiazine derivatives have been known to cause serious side effects, like extrapyramidal symptoms, but also skin disorders which mechanism has not been fully established. The aim of this study was to examine the interaction between prochlorperazine and melanin as well as to estimate the effect of prochlorperazine on cell viability, melanogenesis and antioxidant defense system in normal human melanocytes...
March 1, 2017: Die Pharmazie
Joao Henrique Neves Soares, Alysson Roncally Carvalho, Bruno Curty Bergamini, Maria Alice Kuster Gress, Frederico Caetano Jandre, Walter Araujo Zin, Antonio Giannella-Neto
PURPOSE: We compared respiratory mechanics between the positive end-expiratory pressure of minimal respiratory system elastance (PEEP minErs ) and three levels of PEEP during low-tidal-volume (6 mL/kg) ventilation in rats. METHODS: Twenty-four rats were anesthetized, paralyzed, and mechanically ventilated. Airway pressure (P aw ), flow (F), and volume (V) were fitted by a linear single compartment model (LSCM) P aw (t) = E rs × V(t) + R rs × F(t) + PEEP or a volume- and flow-dependent SCM (VFDSCM) P aw (t) = (E 1 + E 2 × V(t)) × V(t) + (K 1 + K 2 × |F(t)|) × F(t) + PEEP, where E rs and R rs are respiratory system elastance and resistance, respectively; E 1 and E 2 × V are volume-independent and volume-dependent E rs , respectively; and K 1 and K 2 × F are flow-independent and flow-dependent R rs , respectively...
February 12, 2018: Lung
Chaitra Shankar, Balaji Veeraraghavan, Laura Eve Buchnan Nabarro, Raji Ravi, Naveen Kumar Devanga Ragupathi, Priscilla Rupali
BACKGROUND: Hypervirulent K. pneumoniae (hvKp) causes severe community acquired infections, predominantly in Asia. Though initially isolated from liver abscesses, they are now prevalent among invasive infections such as bacteraemia. There have been no studies reported till date on the prevalence and characterisation of hvKp in India. The objective of this study is to characterise the hypervirulent strains isolated from bacteraemic patients for determination of various virulence genes and resistance genes and also to investigate the difference between healthcare associated and community acquired hvKp with respect to clinical profile, antibiogram, clinical outcome and molecular epidemiology...
January 8, 2018: BMC Microbiology
Subramanyam Dasari, Angela Lincy Prem Antony Samy, Andre Kajdacsy-Balla, Maarten C Bosland, Gnanasekar Munirathinam
The aim of this study was to evaluate the therapeutic effects of vitamin K2 (VK2) on castration-resistant prostate cancer (CRPC) and its anti-cancer mechanisms in a pre-clinical study using a VCaP cell line (ATCC ® CRL-2876™) which was established from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. Our data showed that VK2 significantly inhibited CRPC VCaP cell proliferation in a dosedependent manner at 48 h treatment in vitro. In addition, VK2 reduced the migration potential of VCaP cells and inhibited anchorage-independent growth of these cells...
February 9, 2018: Food and Chemical Toxicology
Atef G Hussein, Randa H Mohamed, Sally M Shalaby, Dalia M Abd El Motteleb
OBJECTIVES: The biological mechanisms behind the association between vitamin K (Vit K) and glucose metabolism are uncertain. We aimed to analyze the expression of insulin 1 (Ins 1), insulin 2 (Ins 2) and cyclin D2, the expression of adiponectin and UCP-1 . In addition, we aimed to estimate the doses of Vit K2 able to affect various aspects of glucose and energy metabolism in type 2 diabetes. METHODS: Thirty adult male rats were allocated equally into five groups: control group, diabetes mellitus group, and groups 3, 4, and 5, which received Vit K 2 at three daily dose levels (10, 15, and 30 mg/kg, respectively) for 8 wk...
March 2018: Nutrition
Nathalie Bussières, Osama Hamid Ababneh, Mohammed Ali Abu Ameerh, Muawyah D Al Bdour
PURPOSE: To characterize the asymmetry between both eyes in patients with keratoconus based on corneal tomography. MATERIALS AND METHODS: All patients with keratoconus who presented to the eye clinic at Jordan University Hospital between January 2008 and November 2011 were included in the study. Using computerized corneal tomography, the keratometric values and indices of both eyes of participants with keratoconus and normal controls were compared. For both eyes to be considered symmetrical, the difference between the mean curvature power (Km), flat curvature power (K1), or steep curvature power (K2) in both eyes was equal to or <2...
October 2017: Middle East African Journal of Ophthalmology
Zhi-Quan Huang, Wei-Chih Chen, Gennevieve M Macam, Christian P Crisostomo, Shin-Ming Huang, Rong-Bin Chen, Marvin A Albao, Der-Jun Jang, Hsin Lin, Feng-Chuan Chuang
The abounding possibilities of discovering novel materials has driven enhanced research effort in the field of materials physics. Only recently, the quantum anomalous hall effect (QAHE) was realized in magnetic topological insulators (TIs) albeit existing at extremely low temperatures. Here, we predict that MPn (M =Ti, Zr, and Hf; Pn =Sb and Bi) honeycombs are capable of possessing QAH insulating phases based on first-principles electronic structure calculations. We found that HfBi, HfSb, TiBi, and TiSb honeycomb systems possess QAHE with the largest band gap of 15 meV under the effect of tensile strain...
February 7, 2018: Nanoscale Research Letters
Sadek A Nehmeh, Jazmin Schwartz, Milan Grkovski, Ivan Yeung, Charles M Laymon, Mark Muzi, John L Humm
PURPOSE: To assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET. METHODS: Study-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed. RESULTS: Study-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs...
January 12, 2018: Clinical Imaging
Linda Kim, Katrina Brudzynski
Our recent research indicated that honey active macromolecules form colloidal particles that scatter the light and produce elaborate UV spectral profile dominated by double absorption peaks at 240-250 nm. The absorption at 240-250 nm signified the stable honey conformation that supported antibacterial activity and hydrogen peroxide production. Our aim was to identify the bioactive constituent relevant to this absorption. The methodology included activity-guided fractionation of honey through size-exclusion chromatography, solid-phase extraction and UPLC-UV-MS...
May 30, 2018: Food Chemistry
Qin-Hua Song, Shao-Lin Wang, Lin Zhong
Phosgene and its substitutes, diphosgene and triphosgene, are highly toxic and widely used chemicals, so it is necessary to investigate their reactivity and develop facile, sensitive and specific methods for detecting them. In this work, we have developed a new 1,8-naphthalimide-based fluorescent chemosensor, Phos-2, which exhibits high sensitivity (detection limits, 0.2-0.7 nM), high selectivity to phosgene and its substitutes over nitric oxide (NO), various acyl chlorides and nerve agent mimics in solutions...
February 5, 2018: Chemistry: a European Journal
Nawaf Abu-Khalaf, Abdel Naser Zaid, Nidal Jaradat, Alaaldin AlKilany, Basima Abu Rumaila, Rowa Al Ramahi, Shrouq Shweiki, Safaa Nidal, Nibal Surakhi
Background: The taste of oral liquid dosage forms is a crucial factor that impacts paediatric patient compliance. The electronic tongue (ET) is an emerging tool that could be useful in taste assessment in order to minimize the involvement of humans in such evaluations. Purpose: The aim of this study is to evaluate the taste of commercially available clarithromycin (CM) oral pharmaceutical suspensions in the Palestinian market. Method: Commercially available CM suspensions (the brand Klacid® and two generic K1 and K2) were assayed using the high performance liquid chromatography (HPLC) method...
February 3, 2018: Sensors
Gabriela de Jonge, Talita L Dos Santos, Bruno R Cruz, Mackelly Simionatto, Jeanine I M Bittencourt, Everson A Krum, Mariane F Moss, Danielle Cristyane K Borato
BACKGROUND: Hemolysis may occur in vivo, under pathological conditions, or in vitro, related to pre-analytical errors. Hemolyzed samples may produce unreliable results, leading to errors in diagnostic and monitoring evaluations. This study aims to evaluate the interference of in vitro hemolysis on the interpretation of the parameters of the blood cell-counting performed by the impedance method. METHODS: Peripheral blood samples were collected in anticoagulant K2-EDTA and subsequently divided into three 1...
February 3, 2018: Journal of Clinical Laboratory Analysis
Ming-Tsun Tsai, Ying-Ying Chen, Wei-Jeng Chang, Szu-Yuan Li
BACKGROUND: Vascular calcification is highly prevalent in end-stage renal disease (ESRD) and is a significant risk factor for future cardiovascular events and death. Warfarin use results in dysfunction of matrix Gla protein, an inhibitor of vascular calcification. However, the effect of warfarin on vascular calcification in patients with ESRD is still not well characterized. Thus we investigated whether arterial calcification can be accelerated by warfarin treatment both in vitro and in vivo using a mouse remnant kidney model...
January 23, 2018: Journal of the Chinese Medical Association: JCMA
L Havela, S Mašková, J Kolorenč, E Colineau, J-C Griveau, R Eloirdi
We established the basic electronic properties of ζ-Pu19Os, which is a close analogue to β-Pu, and its low-temperature variety, η-Pu19Os. Their magnetic susceptibility is 15% higher than for δ-Pu. A specific heat study of ζ-Pu19Os shows a soft lattice similar to δ-Pu, leading to a low Debye temperature Θ D  =  101 K. The linear electronic coefficient γ related to the quasiparticle density of states at the Fermi level points to a higher value, 55  ±  2 mJ (mol Pu K2)-1, compared to 40 mJ (mol K2)-1 for δ-Pu...
February 1, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Li Liu, Sarah E Wheeler, Raman Venkataramanan, Jacqueline A Rymer, Anthony F Pizon, Michael J Lynch, Kenichi Tamama
Objectives: Illicit drug abuse has reached an epidemic level in the United States. Drug overdose has become the leading cause of injury-related deaths since 2008 due to the recent surge of opioid overdose by heroin, controlled prescription drugs, and nonmethadone synthetic opioids. Synthetic designer drugs such as synthetic cathinones ("bath salts") and synthetic cannabinoids ("Spice" and "K2") continue to emerge and attract recreational users. Methods: The emergence of new drugs of abuse poses a steep challenge for clinical toxicology laboratories...
January 29, 2018: American Journal of Clinical Pathology
Xihua Wu, Zhemin Li, Hui Liu, Peng Wang, Li Wang, Xue Fang, Xiaowen Sun, Wenfeng Ni, Qiang Yang, Zhiming Zheng, Genhai Zhao
The effect of methanol addition on the heterologous expression of isoprenyl transferase NovQ was studied in Pichia pastoris Gpn12, with menadione and isopentenol as precursors to catalyze vitamin K2 (MK-3) synthesis. The expression of NovQ increased by 36% when 2% methanol was added every 24 h. The influence of initial pH, temperature, methanol addition, precursors (menadione, isopentenol) addition, catalytic time and cetyltrimethyl-ammonium bromide (CTAB) addition were explored in the P. pastoris whole-cell catalytic synthesis process of MK-3 in shaking flask...
January 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
Fan Zhang, Xin Ma, Hongzhao Li, Yu Zhang, Xintao Li, Luyao Chen, Gang Guo, Yu Gao, Liangyou Gu, Yongpeng Xie, Junyao Duan, Xu Zhang
Forkhead box K2 (FOXK2) belongs to the forkhead box transcription factor family. Recent studies have revealed that FOXK2 plays essential roles in cancer cell proliferation and survival. However, the biological function of FOXK2 in renal cell carcinoma remains unexplored. In this study, we demonstrated that FOXK2 mRNA and protein levels were decreased in clear-cell renal cell carcinoma (ccRCC) tissues compared with that in corresponding non-tumor renal tissues, and decreased FOXK2 levels were associated with poor prognosis in ccRCC patients after nephrectomy...
January 25, 2018: International Journal of Cancer. Journal International du Cancer
Danijela Bakarić, Jens Spanget-Larsen
2-ethynylpyridine (2-EP) presents a multifunctional system capable of participation in hydrogen-bonded complexes utilizing hydrogen bond donating (CH, Aryl-H) and hydrogen bond accepting functions (N-atom, CC and pyridine π-systems). In this work, IR spectroscopy and theoretical calculations are used to study possible 2-EP dimer structures as well as their distribution in an inert solvent such as tetrachloroethene. Experimentally, the CH stretching vibration of the 2-EP monomer absorbs close to 3300 cm-1, whereas a broad band with maximum around 3215 cm-1 emerges as the concentration rises, indicating the formation of hydrogen-bonded complexes involving the CH moiety...
January 20, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Li Fu, Mei Huang, XinZhou Zhang, XiaoYing Yang, Yao Liu, LuHua Zhang, ZhiKun Zhang, GuangXi Wang, YingShun Zhou
The aim of this study is to determine the frequency of virulence genes in high biofilm formation blaKPC-2 producing Klebsiella pneumoniae strains collected over a period of two years. A total of 43 non-repetitive high biofilm blaKPC-2 producing isolates were screened from 429 strains. The MIC of carbapenems (imipenem and meropenem) ranged from 4 to 32 μg/ml. The OD595 value of the biofilm ranged from 0.56 to 2.56. The K1, K2, K5, K20, K54, K57 genotypes, MLST and virulence factors, including entB, ybtS, mrkD, fimH, rmpA, allS, iutA, kfu, wcaG, aerobaction, fecIRA, shiF, magA and pagO gene, were determined by PCR...
January 19, 2018: Microbial Pathogenesis
Eike M Langer, Olaf Walter, Jean-Yves Colle, Dirk Bosbach, Evgeny V Alekseev
A study of neptunium (Np) chemistry in the complex oxo-selenium system has been performed. Hereby, two sets of precipitation experiments were conducted, investigating the influence of the initial oxidation state of selenium using SeIVO2 and H2SeVIO4 with NpV in alkali nitrate solution, keeping the ratio of Np/Se constant. Surprising results were observed. Five novel neptunium and selenium bearing compounds have been obtained by slow evaporation from aqueous solution. The novel NpIV phase K4-x[Np(SeO3)4-x(HSeO3)x]·(H2O)1...
January 22, 2018: Inorganic Chemistry
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