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https://www.readbyqxmd.com/read/28339022/cytochrome-p450-2e1-increases-the-sensitivity-of-hepatoma-cells-to-vitamin-k2
#1
Lu Li, Lu Wang, Rui Song, Guangliang Chen, Yanyan Liu
Although vitamin K2 (VK2) exhibits inhibitory effects on the viability of hepatoma cells, hepatoma cells are insensitive to VK2. Therefore, this investigation is an attempt to enhance the sensitivity of hepatoma cells to VK2. Our results showed that VK2 acted synergistically with ethanol (EtOH) to inhibit the viability of Smmc-7721 cells, mainly because cytochrome P450 2E1 (CYP2E1) was activated by EtOH. The synergistic effect of VK2 and EtOH was also observed in QGY-7703 cells, which also express CYP2E1. However, in HepG2 cells, which do not express CYP2E1, the synergistic effect of VK2 and EtOH was not observed...
March 24, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28334288/genome-sequencing-and-comparative-analysis-of-three-hypermucoviscous-klebsiella-pneumoniae-strains-isolated-in-russia
#2
Angelina A Kislichkina, Anastasia I Lev, Ekaterina V Komisarova, Nadezhda K Fursova, Vera P Myakinina, Tatiana N Mukhina, Alexander A Bogun, Nikolay V Volozhantsev
The prevalence and characteristics of hypermucoviscous (HV) strains among Klebsiella pneumoniae isolated in Russian hospitals were investigated. The HV strains were accounted for 11% K. pneumoniae isolates collected on the period from 2011 to 2016, and were characterized by belonging to K1, K2, K20 and K57 serotypes. Whole genome sequences (WGSs) of K. pneumoniae HV clinical strains KPi261 (SCPM-O-B-7850) and KPB4010 (SCPM-O-B-7846) belonging to K1 and K2 capsular types, as well as WGSs of K. pneumoniae strain KPM9 (SCPM-O-B-7749) of K20 capsular type isolated from freshwater were completed...
March 9, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28333111/solanesol-biosynthesis-in-plants
#3
REVIEW
Ning Yan, Yanhua Liu, Hongbo Zhang, Yongmei Du, Xinmin Liu, Zhongfeng Zhang
Solanesol is a non-cyclic terpene alcohol composed of nine isoprene units that mainly accumulates in solanaceous plants. Solanesol plays an important role in the interactions between plants and environmental factors such as pathogen infections and moderate-to-high temperatures. Additionally, it is a key intermediate for the pharmaceutical synthesis of ubiquinone-based drugs such as coenzyme Q10 and vitamin K2, and anti-cancer agent synergizers such as N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl) ethylenediamine (SDB)...
March 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28330262/biodegradation-of-isoproturon-by-pseudoxanthomonas-sp-isolated-from-herbicide-treated-wheat-fields-of-tarai-agro-ecosystem-pantnagar
#4
Krishna Giri, Shailseh Pandey, Rajesh Kumar, J P N Rai
A gram-negative, rod-shaped, isoproturon (IPU) utilizing bacterium was isolated from herbicide-applied wheat fields of Tarai agro-ecosystem, Pantnagar. The phylogenetic sequence analysis based on 16S rRNA sequence revealed that the isolate could be a distinct species within the genus Pseudomonas. The isolate was a close relative of Pseudoxanthomonas japonensis (95 % similarity) and designated as K2. The bacterial isolate showed positive reaction for oxidase, catalase, and 20 carbohydrates using KB009 Part A and B HiCarbohydrate™ Kit...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28323623/vitamin-k2-in-the-prevention-of-cardiovascular-diseases-and-diabetes
#5
Andrew W Campbell
No Abstract Available.
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28322963/the-effect-of-oxaloacetic-acid-on-tyrosinase-activity-and-structure-integration-of-inhibition-kinetics-with-docking-simulation
#6
Lin Gou, Jinhyuk Lee, Hao Hao, Yong-Doo Park, Yi Zhan, Zhi-Rong Lü
Oxaloacetic acid (OA) is naturally found in organisms and well known as an intermediate of citric acid cycle producing ATP. We evaluated the effects of OA on tyrosinase activity and structure via integrating methods of enzyme kinetics and computational simulations. OA was found to be a reversible inhibitor of tyrosinase and its induced mechanism was the parabolic non-competitive inhibition type (IC50=17.5±0.5mM and Ki=6.03±1.36mM). Kinetic measurements by real-time interval assay showed that OA induced multi-phasic inactivation process composing with fast (k1) and slow (k2) phases...
March 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28317710/influence-of-microwave-vacuum-drying-on-glass-transition-temperature-gelatinization-temperature-physical-and-chemical-qualities-of-lotus-seeds
#7
Yingting Zhao, Yajun Jiang, Baodong Zheng, Weijing Zhuang, Yafeng Zheng, Yuting Tian
This study investigated the effects of microwave power density on effective moisture diffusion coefficient (Deff), glass transition temperature (Tg), gelatinization temperature (TP), physical and chemical qualities of lotus seeds during microwave vacuum drying. Deff increased by 42% and 127% at 15W/g and 20W/g, respectively, when compared with 10W/g. TP was negatively correlated with the relaxation times of T21 and T22, while Tg was negatively correlated with the relative areas A22. The rates of change of color were observed to be divided roughly into two periods, consisting of a rapid change caused by enzymatic browning and a slow change caused by non-enzymatic browning...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28316557/achieving-prudent-dementia-care-palliare-an-international-policy-and-practice-imperative
#8
Debbie Tolson, Anne Fleming, Elizabeth Hanson, Wilson de Abreu, Manuel Lillo Crespo, Rhoda Macrae, Graham Jackson, Simona Hvalič-Touzery, Iva Holmerová, Pirkko Routasalo
This paper examines the provision of integrated advanced dementia care within seven European countries and critically reviews the potential contribution of the Prudent Healthcare perspective as a starting point for reform. Progressive efforts to innovate, promote quality and integrate care are tempered with the reality of resource constraints. Some policy makers in Europe and North America have turned their attention to the principles of Prudent Healthcare as a potential mechanism to maximise benefits for patients within available resources...
December 31, 2016: International Journal of Integrated Care
https://www.readbyqxmd.com/read/28293952/higher-pedot-molecular-weight-giving-rise-to-higher-thermoelectric-property-of-pedot-pss-a-comparative-study-of-cleviostm-p-and-cleviostm-ph1000
#9
Zeng Fan, Donghe Du, Hongyan Yao, Jianyong Ouyang
Poly(3,4-ethylenedioxuthiphene):poly(styrenesulfonate) (PEDOT:PSS) is a promising candidate as the next-generation thermoelectric (TE) material. Its TE properties are strongly dependent on its chemical and electronic structures. In this paper, we investigated the effect of PEDOT molecular weight on the TE properties of PEDOT:PSS films by a comparative study on two commercial grades of PEDOT:PSS, CleviosTM P and CleviosTM PH1000. Dynamic light scattering (DLS) and Raman spectra imply that the PEDOT of CleviosTM PH1000 possesses longer conjugated chains than that of CleviosTM P...
March 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28287234/synthesis-of-a-dimeric-3%C3%AE-hydroxy-7%C3%AE-12%C3%AE-diamino-5%C3%AE-cholan-24-oate-conjugate-and-its-derivatives-and-the-effect-of-lipophilicity-on-their-anion-transport-efficacy
#10
Zhi Li, Yun Chen, De-Qi Yuan, Wen-Hua Chen
A dimeric 3α-hydroxy-7α,12α-diamino-5β-cholan-24-oate conjugate and its derivatives having alkyl chains of varying length from methyl to n-pentyl groups on the amido bonds were synthesized and fully characterized on the basis of NMR ((1)H and (13)C) and ESI MS (LR and HR) data. Their transmembrane anion transport activities were investigated in detail by means of a chloride ion selective electrode technique and the pyranine assay. The data indicate that this set of compounds is capable of promoting the transmembrane transport of anions, presumably via an anion exchange process and a mobile carrier mechanism...
March 13, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28278688/molecular-phylogenetic-analysis-of-genus-osteobrama-heckel-1843-and-discovery-of-osteobrama-serrata-sp-nov-from-north-east-india
#11
Mahender Singh, Rashmi Verma, Rameshori Yumnam, Waikhom Vishwanath
Genus Osteobrama Heckel is characterized by strongly compressed, fairly deep body with abdominal edge sharp and trenchant entirely or from the pelvic fin base to vent; anal fin long with 14-36 rays, of which 11-13 are branched rays. The fishes of this genus are distributed in Pakistan, India, Bangladesh, Burma, and Yunnan (China). Present study involve six Osteobrama species viz. O. belangeri, O. cotio, O. cunma, O. feae, O. serrata sp. nov., and O. vigorsii. Out of the 655 positions analyzed in the COI sequence dataset, 171 positions (26...
March 2, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28275931/the-concentration-of-vanadium-in-pathologically-altered-human-kidneys
#12
Aleksandra Wilk, Barbara Wiszniewska, Dagmara Szypulska-Koziarska, Paulina Kaczmarek, Maciej Romanowski, Jacek Różański, Marcin Słojewski, Kazimierz Ciechanowski, Małgorzata Marchelek-Myśliwiec, Elżbieta Kalisińska
Vanadium has a unique and beneficial effect on both humans and animal organisms; however, excessive amount of the above-mentioned metal can cause many alterations in tissues and organs, including the kidneys. The aim of the study was to determine the concentration of vanadium (V) in the kidneys removed from patients due to lesions of various etiologies, including the rejection of the transplanted kidneys. Additionally, we determined the influence of selected biological and environmental factors on the V concentration...
March 9, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28275304/subclinical-atherosclerosis-is-linked-to-small-intestinal-bacterial-overgrowth-via-vitamin-k2-dependent-mechanisms
#13
Francesca Romana Ponziani, Maurizio Pompili, Enrico Di Stasio, Maria Assunta Zocco, Antonio Gasbarrini, Roberto Flore
AIM: To assess the rate of matrix Gla-protein carboxylation in patients with small intestinal bacterial overgrowth (SIBO) and to decipher its association with subclinical atherosclerosis. METHODS: Patients with suspected SIBO who presented with a low risk for cardiovascular disease and showed no evidence of atherosclerotic plaques were included in the study. A glucose breath test was performed in order to confirm the diagnosis of SIBO and vascular assessment was carried out by ultrasound examination...
February 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28265719/health-state-utility-values-and-patient-reported-outcomes-before-and-after-vertebral-and-non-vertebral-fractures-in-an-osteoporosis-clinical-trial
#14
T Imai, S Tanaka, K Kawakami, T Miyazaki, H Hagino, M Shiraki
We assessed the health state utility value (HSUV) reductions associated with vertebral fractures using data collected in the Japanese Osteoporosis Intervention Trial-03 (JOINT-03). Our analysis revealed that assessment of HSUVs after morphometric vertebral fracture is important to capture the burden of vertebral fractures. INTRODUCTION: Evaluation of the HSUV after fracture is important to calculate the quality-adjusted life years (QALYs) of osteoporosis patients, which is essential information in the context of health economic evaluation...
March 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28264560/overcoming-an-extreme-drug-resistant-xdr-pathogen-avibactam-restores-susceptibility-to-ceftazidime-for-burkholderia-cepacia-complex-isolates-from-cystic-fibrosis-patients
#15
Krisztina M Papp-Wallace, Scott A Becka, Elise T Zeiser, Nozumi Ohuchi, Maria F Mojica, Julian A Gatta, Monica Falleni, Delfina Tosi, Elisa Borghi, Marisa L Winkler, Brigid M Wilson, John J LiPuma, Michiyoshi Nukaga, Robert A Bonomo
Burkholderia multivorans is a significant health threat to persons with cystic fibrosis (CF). Infections are difficult to treat as this pathogen is inherently resistant to multiple antibiotics. Susceptibility testing of isolates obtained from CF respiratory cultures revealed that single agents selected from different antibiotic classes were unable to inhibit growth. However, all isolates were found to be susceptible to ceftazidime when combined with the novel non-β-lactam β-lactamase inhibitor, avibactam (all minimum inhibitor concentrations (MICs) were ≤ 8 mg/L of ceftazidime and 4 mg/L of avibactam)...
March 6, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28263430/single-molecule-mechanochemical-characterization-of-e-coli-pol-iii-core-catalytic-activity
#16
M Nabuan Naufer, David A Murison, Ioulia Rouzina, Penny J Beuning, Mark C Williams
Pol III core is the three-subunit subassembly of the E. coli replicative DNA polymerase III holoenzyme. It contains the catalytic polymerase subunit α, the 3' → 5' proofreading exonuclease ε, and a subunit of unknown function, θ. We employ optical tweezers to characterize pol III core activity on a single DNA substrate. We observe polymerization at applied template forces F<25 pN and exonucleolysis at F>30 pN. Both polymerization and exonucleolysis occur as a series of short bursts separated by pauses...
March 6, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28261488/biodegradation-of-total-petroleum-hydrocarbons-from-acidic-sludge-produced-by-re-refinery-industries-of-waste-oil-using-in-vessel-composting
#17
Alireza Asgari, Ramin Nabizadeh, Amir Hossein Mahvi, Simin Nasseri, Mohammad Hadi Dehghani, Shahrokh Nazmara, Kamyar Yaghmaeian
BACKGROUND: In Iran, re-refinery industry has been developed many years ago based on the acid-clay treatment. Acidic sludge with high concentration of total petroleum hydrocarbon (TPH) is the final products of some facilities. In this study removal of TPH by aerated in-vessel composting was investigated. METHODS: In order to microorganisms seeding and nutrient providing, urban immature compost was added as an amendment to acidic sludge. The ratios of acidic sludge (AS) to compost were, 1:0 (as control), 1:5, 1:8, 1:10, 1:15, 1:20, 1:30, 1:40, 1:50, 1:75 and 1:100 (as dry basis) at a C: N: P ratio of 100:5:1 and 45-65% moisture content for 70 days...
2017: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/28254628/mitochondrial-genomic-comparison-of-clonorchis-sinensis-from-south-korea-with-other-isolates-of-this-species
#18
Daxi Wang, Neil D Young, Anson V Koehler, Patrick Tan, Woon-Mok Sohn, Pasi K Korhonen, Robin B Gasser
Clonorchiasis is a neglected tropical disease that affects >35 million people mainly in China, Vietnam, South Korea and some parts of Russia. The disease-causing agent, Clonorchis sinensis, is a liver fluke of humans and other piscivorous animals, and has a complex aquatic life cycle involving snails and fish intermediate hosts. Chronic infection in humans causes liver disease and associated complications including malignant bile duct cancer. Central to control and to understanding the epidemiology of this disease is knowledge of the specific identity of the causative agent as well as genetic variation within and among populations of this parasite...
February 22, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28250595/genetic-variation-of-a-global-germplasm-collection-of-chickpea-cicer-arietinum-l-including-italian-accessions-at-risk-of-genetic-erosion
#19
C De Giovanni, S Pavan, F Taranto, V Di Rienzo, M M Miazzi, A R Marcotrigiano, G Mangini, C Montemurro, L Ricciardi, C Lotti
Chickpea (Cicer arietinum L.) is one of the most important legumes worldwide. We addressed this study to the genetic characterization of a germplasm collection from main chickpea growing countries. Several Italian traditional landraces at risk of genetic erosion were included in the analysis. Twenty-two simple sequence repeat (SSR) markers, widely used to explore genetic variation in plants, were selected and yielded 218 different alleles. Structure analysis and hierarchical clustering indicated that a model with three distinct subpopulations best fits the data...
January 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28250342/antitumor-allium-sulfides
#20
Toshihiro Nohara, Yukio Fujiwara, Mona El-Aasr, Tsuyoshi Ikeda, Masateru Ono, Daisuke Nakano, Junei Kinjo
We examined the sulfides in onion (Allium cepa L.), Welsh onion (A. fistulosum L.), and garlic (A. sativum L.), and obtained three new thiolane-type sulfides (onionins A1-A3) from onion; two new thiabicyclic-type sulfides (welsonins A1, A2), together with onionins A1-A3, from Welsh onion; and six new acyclic-type sulfides (garlicnins L-1-L-4, E, and F), ten new thiolane-type sulfides (garlicnins A, B1-B4, C1-C3, K1, and K2), and three new atypical cyclic-type sulfides (garlicnins G, I, and J) from garlic. Acetone extracts showed the potential of these sulfides in inhibiting the polarization of M2 activated macrophages that are capable of suppressing tumor-cell proliferation...
2017: Chemical & Pharmaceutical Bulletin
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