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https://www.readbyqxmd.com/read/28108554/genome-wide-analysis-of-lncrna-and-mrna-expression-during-differentiation-of-abdominal-preadipocytes-in-the-chicken
#1
Tao Zhang, Xiangqian Zhang, Kunpeng Han, Genxi Zhang, Jinyu Wang, Kaizhou Xie, Qian Xue
Long non-coding RNAs (lncRNAs) regulate adipogenesis and other processes associated with metabolic tissue development and function. However, little is known about the function and profile of lncRNAs during preadipocyte differentiation in the chicken (Gallus gallus). Herein, lncRNA and mRNA expression in preadipocytes at different stages of differentiation were analyzed using RNA sequencing. A total of 1,300,074,528 clean reads and 27,023 novel lncRNAs were obtained from 12 samples. The number of genes (1,336 lncRNAs and 1,759 mRNAs; 3,095 in total) differentially expressed across various stages declined as differentiation progressed...
January 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28107947/surface-enhanced-raman-spectroscopy-sers-as-a-method-for-the-toxicological-analysis-of-synthetic-cannabinoids
#2
Thaddeus Mostowtt, Bruce McCord
Synthetic cannabinoids (K2, spice) present problems in forensic investigations because standard presumptive methods, such as immunoassays, are insufficiently specific for the wide range of potential target compounds. This issue can lead to problems with low sensitivity and yield false negative results. A potential solution to this problem is surface enhanced Raman spectroscopy (SERS). In this study we demonstrate the analysis of a set of structurally similar synthetic cannabinoids using SERS. The procedure involves mixing the analyte with gold nanoparticles prepared in a solution containing alkali or alkaline earth salt solutions...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107005/kinetic-analysis-and-mechanism-of-the-hydrolytic-degradation-of-squaramides-and-squaramic-acids
#3
Marta Ximenis, Emilio Bustelo, Andrés G Algarra, Manel Vega, Carmen Rotger, Manuel G Basallote, Antonio Costa
The hydrolytic degradation of squaramides and squaramic acids, the product of partial hydrolysis of squaramides, has been evaluated by UV spectroscopy at 37°C in the pH range 3-10. Under these conditions, the compounds are kinetically stable over long time periods (>100 d). At pH > 10, the hydrolysis of the squaramate anions shows first-order dependence on both squaramate and OH-. At the same temperature and [OH-], the hydrolysis of squaramides usually displays biphasic spectral changes (A → B → C kinetic model) with formation of squaramates as detectable reaction intermediates...
January 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28106995/nucleophilicity-parameters-of-arylsulfonyl-substituted-halomethyl-anions
#4
Zhen Li, Quan Chen, Peter Mayer, Herbert Mayr
The rates of the reactions of the arylsulfonyl substituted carbanions carrying α-chloro and α-bromo substituents 1a-e with quinone methides 2a-g and benzylidenemalonates 2h-i in DMSO were determined photometrically at 20 °C. The reactions were carried out under pseudo-first-order conditions, and the second-order rate constants were obtained as the slopes of the plots of the pseudo-first-order rate constants versus the concentrations of the reactants used in excess. The second-order rate constants correlate linearly with the parameters E of the reference electrophiles according to the linear free-energy relationship log k2(20 °C) = sN(N + E), which allowed to derive the nucleophile-specific parameters N and sN of the carbanions 1a-e...
January 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28097771/solution-synthesis-structure-and-co2-reduction-reactivity-of-a-scandium-ii-complex-sc-n-sime3-2-3
#5
David H Woen, Guo P Chen, Joseph W Ziller, Timothy J Boyle, Filipp Furche, William J Evans
The first crystallographically characterizable complex of Sc(2+) , [Sc(NR2 )3 ](-) (R=SiMe3 ), has been obtained by LnA3 /M reactions (Ln=rare earth metal; A=anionic ligand; M=alkali metal) involving reduction of Sc(NR2 )3 with K in the presence of 2.2.2-cryptand (crypt) and 18-crown-6 (18-c-6) and with Cs in the presence of crypt. Dark maroon [K(crypt)](+) , [K(18-c-6)](+) , and [Cs(crypt)](+) salts of the [Sc(NR2 )3 ](-) anion are formed, respectively. The formation of this oxidation state of Sc is also indicated by the eight-line EPR spectra arising from the I=7/2 (45) Sc nucleus...
January 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28092834/computational-exploration-of-regioselectivity-and-atmospheric-lifetime-in-no3-initiated-reactions-of-ch3och3-and-ch3och2ch3
#6
Jin-Ting Ye, Feng-Yang Bai, Shao-Qing Shi, Xiu-Mei Pan
The NO3-initiated reactions of CH3OCH3 and CH3OCH2CH3 have been investigated by the BHandHLYP method in conjunction with the 6-311G(d,p) basis set. Thermodynamic and kinetic data are further refined using the comparatively accurate CCSD(T) method. According to the values of reaction enthalpies (ΔHr,298(θ)) and reaction Gibbs free energies (ΔGr,298(θ)) from CH3OCH2CH3 with NO3 system, we find that H-abstraction pathway from the α-CH2 group is more exothermic. It is further confirmed by the calculated CH bond dissociation energy of CH3OCH2CH3 molecule...
January 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28075568/reaction-pathways-and-kinetics-of-a-cyanobacterial-neurotoxin-%C3%AE-n-methylamino-l-alanine-bmaa-during-chlorination
#7
Yiting Chen, Wan-Ru Chen, Zhiquan Liu, Tsair-Fuh Lin
β-N-Methylamino-L-alanine (BMAA), a probable cause of the amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC), or Alzheimer's disease, has been identified in more than 20 cyanobacterial genera. However, its removal and fate in drinking water has never been reported before. In this study, the reaction of BMAA with chlorine, a common drinking-water oxidant/disinfectant, was investigated. A liquid chromatograph coupled with a triple quadrupole mass spectrometer was employed to quantify BMAA and its intermediates...
January 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28069206/optimization-of-simultaneous-ultrasound-assisted-toxic-dyes-adsorption-conditions-from-single-and-multi-components-using-central-composite-design-application-of-derivative-spectrophotometry-and-evaluation-of-the-kinetics-and-isotherms
#8
Ebrahim Sharifpour, Hedayat Haddadi, Mehrorang Ghaedi
Present study is devoted on the efficient application of Sn (O, S)-NPs -AC for simultaneous sonicated accelerated adsorption of some dyes from single and multi-components systems. Sn (O, S) nanoparticles characterization by FESEM, EDX, EDX mapping and XRD revel its nano size structure with high purity of good crystallinity. Present adsorbent due to its nano spherical shape particles with approximate diameter of 40-60nm seems to be highly effective in this regard. The effects of five variables viz. pH (3.5-9...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28068285/vitamin-k2-improves-anxiety-and-depression-but-not-cognition-in-rats-with-metabolic-syndrome-a-role-of-blood-glucose
#9
Silvia M Gancheva, Maria D Zhelyazkova-Savova
BACKGROUND: The metabolic syndrome is a socially important disorder of energy utilization and storage, recognized as a factor predisposing to the development of depression, anxiety and cognitive impairment in humans. AIM: In the present study we examined the effects of vitamin K2 on the behavior of rats with metabolic syndrome and looked for relationships with the effects on blood sugar. MATERIALS AND METHODS: Male Wistar rats were divided in four groups: a control group on a regular rat chow, a metabolic syndrome (MS) group fed a high-fat high-fructose diet, a control group treated with vitamin K2 and a MS group treated with vitamin K2...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28062596/prediction-of-the-clinical-standardized-uptake-value-ratio-in-amyloid-pet-imaging-using-a-biomathematical-modeling-approach-towards-the-efficient-development-of-a-radioligand
#10
Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
OBJECTIVE: Our study aimed to develop a method to mathematically predict the kinetic parameters K1, k2 and BPND of amyloid PET tracers, and finally obtain standardized uptake value ratio (SUVR) values from predicted time-activity curves (TACs) of target and reference regions. METHODS: Ten clinically applied amyloid PET radioligands, (11)C-PIB, (11)C-BF-227, (11)C-AZD2184, (11)C-SB-13, (18)F-FACT, (18)F-Florbetapir, (18)F-Florbetaben, (18)F-Flutemetamol, (18)F-FDDNP and (18)F-AZD4694, were investigated...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28061030/regeneration-of-%C3%AE-carotene-from-radical-cation-by-eugenol-isoeugenol-and-clove-oil-in-the-marcus-theory-inverted-region-for-electron-transfer
#11
Hui-Ting Chang, Hong Cheng, Rui-Min Han, Peng Wang, Jian-Ping Zhang, Leif H Skibsted
Rate of regeneration of β-carotene by eugenol from the β-carotene radical cation, an initial bleaching product of β-carotene, was found by laser flash photolysis and transient absorption spectroscopy to be close to the diffusion limit in chloroform/methanol (9:1, v:v) with a second-order rate constant (k2) of 4.3×109 Lmol-1s-1. at 23 °C. Isoeugenol, more reducing with a standard reduction potential 100 mV lower than eugenol, was slower with k2 = 7.2 ×108 Lmol-1s-1. Regeneration of β-carotene following photobleaching was found 50% more efficient by eugenol, indicating that for the more reducing isoeugenol, the driving force exceeds the reorganization energy for electron transfer significantly in the Marcus theory inverted region...
January 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28051307/highly-efficient-magnetic-nitrogen-doped-porous-carbon-prepared-by-one-step-carbonization-strategy-for-hg2-removal-from-water
#12
Lijin Huang, Man He, Bei-Bei Chen, Qian Cheng, Bin Hu
Hydrophilic magnetic N-doped porous carbon composites (MNPCs) with high special surface areas and rich nitrogen content was prepared via simple one-step carbonization of zinc oxide nanoparticles (ZnO NPs), 2-methylimidazole (HmIm) and Fe3O4@SiO2 magnetic nanoparticles (MNPs) mixture directly. During the carbonization process, ZnO NPs directly reacts with HmIm to yield porous ZIF-8 while the MNPs are incorporated into the frameworks to generate magnetic metal-organic frameworks (MFCs), and the MFCs acts as a self-sacrificing template to prepare MNPC...
January 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28050321/comparison-of-anterior-segment-measurements-obtained-by-aladdin-optical-biometer-and-sirius-corneal-topography
#13
Onur Polat, Zeki Baysal, Serkan Özcan, Sibel İnan, Ümit Übeyt İnan
OBJECTIVES: To assess the agreement of anterior segment parameter measurements derived from Aladdin optical biometer using optical low coherence interferometer and Sirius corneal topography using combined Scheimpflug-Placido disk. MATERIALS AND METHODS: Data obtained using the Aladdin and Sirius systems from 110 eyes of 59 subjects who had no health problems other than refractive errors were retrospectively evaluated. Anterior chamber depth (ACD), flat (K1) and steep (K2) keratometry readings, and white-to-white distance (WTW) measurements taken with both devices were noted...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28047445/su-f-j-172-hybrid-mr-ct-compatible-phantom-for-mr-only-based-radiotherapy
#14
M Kim, S Lee, K Song, S Park, T Suh
PURPOSE: Development of hybrid MR/CT compatible phantom was introduced to fully establish MR image only radiation treatment and this suggested technique using in-house developed hybrid MR/CT compatible phantom image would utilize to generate radiation treatment planning and perform dose calculation without multi-modal registration process or generation of pseudo CT. METHODS: Fundamental characteristics for "hybrid MR/CT compatible phantom" was established: Relaxation times equivalent to human tissue, dielectric properties, homogeneous relaxation times, sufficient strength to fabricate a torso, ease of handling, a wide variety of density material for calibration, chemical and physical stability over an extended time...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047381/su-f-j-213-feasibility-study-of-using-a-dual-energy-cone-beam-ct-decbct-in-proton-therapy-treatment-planning
#15
H Peng, T Kanehira, S Takao, T Matsuura, K Umegaki, H Shirato, L Xing
PURPOSE: The aim of this study is to evaluate the feasibility of using a dual-energy CBCT (DECBCT) in proton therapy treatment planning to allow for accurate electron density estimation. METHODS: For direct comparison, two scenarios were selected: a dual-energy fan-beam CT (high: 140 kVp, low: 80 kVp) and a DECBCT (high: 125 kVp, low: 80 kVp). A Gammex 467 tissue characterization phantom was used, including the rods of air, water, bone (B2-30% mineral), cortical bone (SB3), lung (LN-300), brain, liver and adipose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045455/the-pseudomonas-putida-t6ss-is-a-plant-warden-against-phytopathogens
#16
Patricia Bernal, Luke P Allsopp, Alain Filloux, María A Llamas
Bacterial type VI secretion systems (T6SSs) are molecular weapons designed to deliver toxic effectors into prey cells. These nanomachines have an important role in inter-bacterial competition and provide advantages to T6SS active strains in polymicrobial environments. Here we analyze the genome of the biocontrol agent Pseudomonas putida KT2440 and identify three T6SS gene clusters (K1-, K2- and K3-T6SS). Besides, 10 T6SS effector-immunity pairs were found, including putative nucleases and pore-forming colicins...
January 3, 2017: ISME Journal
https://www.readbyqxmd.com/read/28043055/hip-mechanics-underlie-lower-extremity-power-training-induced-increase-in-old-adults-fast-gait-velocity-the-potsdam-gait-study-pogs
#17
Chantal M I Beijersbergen, Urs Granacher, Martijn Gäbler, Paul DeVita, Tibor Hortobágyi
BACKGROUND: Aging is associated with slowed gait and old compared with young adults generally walk with greater positive hip work (H1) and reduced positive ankle work (A2). The role of exercise interventions on old adults' gait mechanics that underlie training-induced improvements in gait velocity is unclear. We examined the effects of lower extremity power training and detraining on old adults' gait kinetics. METHODS: As part of the Potsdam Gait Study (POGS), healthy old adults completed a no-intervention control period (69...
December 21, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28032678/nacnac-cobalt-mediated-p4-transformations
#18
Manfred Scheer, Fabian Spitzer, Christian Graßl, Gabor Balazs, Eric Mädl, Eva Zolnhofer, Martin Keilwerth, Karsten Meyer
A comparison of P4 activations mediated by low-valent β diketiminato (L) cobalt complexes is presented. The formal Co(0) source [K2(L3Co)2(µ2:ƞ1,ƞ1-N2)] (1) reacts with P4 to form a mixture of the monoanionic complexes [K(thf)6][(L3Co)2(µ2:ƞ4,ƞ4-P4)] (2) and [K(thf)6][(L3Co)2(µ2:ƞ3,ƞ3-P3)] (3). The analogue Co(I) precursor [L3Co(tol)] (4a), however, selectively yields the corresponding neutral derivative [(L3Co)2(µ2:ƞ4,ƞ4-P4)] (5a). Compound 5a undergoes thermal P atom loss to form the unprecedented complex [(L3Co)2(µ2:ƞ3,ƞ3-P3)] (6)...
December 29, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28017991/rheological-properties-and-bread-quality-of-frozen-sweet-dough-with-added-xanthan-and-different-freezing-rate
#19
Mina Akbarian, Arash Koocheki, Mohebbat Mohebbi, Elnaz Milani
In this paper the effects of frozen storage time, xanthan gum and rate of freezing on frozen sweet dough properties and unfermented bread quality was investigated. Results revealed that the water holding capacity, WHC, K1 (stress decay rate) and K2 (residual stress at the end of the stress relaxation experiment) values of frozen dough decreased with increasing frozen storage time and decreasing freezing rate; while the lowest values for these parameters were obtained for samples without xanthan gum. The amount of unfreezable water increased and freezable water decreased with addition of xanthan gum...
October 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28005346/identification-of-crucial-amino-acid-residues-involved-in-agonist-signaling-at-the-gpr55-receptor
#20
Mary A Lingerfelt, Pingwei Zhao, Haleli P Sharir, Dow P Hurst, Patricia H Reggio, Mary E Abood
GPR55 is a newly deorphanized class A G-protein-coupled receptor that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone development, and cancer. Few potent GPR55 ligands have been identified to date. This is largely due to an absence of information about salient features of GPR55, such as residues important for signaling and residues implicated in the GPR55 signaling cascade. The goal of this work was to identify residues that are key for the signaling of the GPR55 endogenous ligand, l-α-lysophosphatidylinositol (LPI), as well as the signaling of the GPR55 agonist, ML184 {CID 2440433, 3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide}...
January 11, 2017: Biochemistry
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