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https://www.readbyqxmd.com/read/27793773/gaba%C3%AF-selective-antagonist-tpmpa-partially-inhibits-gaba-mediated-currents-recorded-from-neurones-and-astrocytes-in-mouse-striatum
#1
Daniel Reyes-Haro, José Antonio Hernández-Santos, Ricardo Miledi, Ataúlfo Martínez-Torres
The neostriatum plays a central role in motor coordination where nerve cells operate neuronal inhibition through GABAergic transmission. The neostriatum expresses a wide range of GABA-A subunits, including GABAρ1 and ρ2 which are restricted to a fraction of GABAergic interneurons and astrocytes. Spontaneous postsynaptic currents (sPSCs) evoked by 4-aminopyridine (4-AP) were recorded from neurones of the dorsal neostriatum, and their frequency was reduced > 50% by the selective GABAρ antagonist (1,2,5,6-Tetrahydropyridine-4-yl) methylphosphinic acid (TPMPA)...
October 25, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27605623/neostriatal-gabaergic-interneurons-mediate-cholinergic-inhibition-of-spiny-projection-neurons
#2
Thomas W Faust, Maxime Assous, James M Tepper, Tibor Koós
UNLABELLED: Synchronous optogenetic activation of striatal cholinergic interneurons ex vivo produces a disynaptic inhibition of spiny projection neurons composed of biophysically distinct GABAAfast and GABAAslow components. This has been shown to be due, at least in part, to activation of nicotinic receptors on GABAergic NPY-neurogliaform interneurons that monosynaptically inhibit striatal spiny projection neurons. Recently, it has been proposed that a significant proportion of this inhibition is actually mediated by activation of presynaptic nicotinic receptors on nigrostriatal terminals that evoke GABA release from the terminals of the dopaminergic nigrostriatal pathway...
September 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27579022/neostriatal-neuronal-activity-correlates-better-with-movement-kinematics-under-certain-rewards
#3
Ioan Opris, Mikhail A Lebedev, Randall J Nelson
This study investigated how the activity of neostriatal neurons is related to the kinematics of movement when monkeys performed visually and vibratory cued wrist extensions and flexions. Single-unit recordings of 142/236 neostriatal neurons showed pre-movement activity (PMA) in a reaction time task with unpredictable reward. Monkeys were pseudo-randomly (75%) rewarded for correct performance. A regression model was used to determine whether the correlation between neostriatal neuronal activity and the kinematic variables (position, velocity, and acceleration) of wrist movement changes as a function of reward contingency, sensory cues, and movement direction...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27074771/neurological-disorders-associated-with-striatal-lesions-classification-and-diagnostic-approach
#4
REVIEW
Davide Tonduti, Luisa Chiapparini, Isabella Moroni, Anna Ardissone, Giovanna Zorzi, Federica Zibordi, Sergio Raspante, Celeste Panteghini, Barbara Garavaglia, Nardo Nardocci
Neostriatal abnormalities can be observed in a very large number of neurological conditions clinically dominated by the presence of movement disorders. The neuroradiological picture in some cases has been described as "bilateral striatal necrosis" (BSN). BSN represents a condition histo-pathologically defined by the involvement of the neostriata and characterized by initial swelling of putamina and caudates followed by degeneration and cellular necrosis. After the first description in 1975, numerous acquired and hereditary conditions have been associated with the presence of BSN...
June 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/26778989/relationship-between-l-dopa-induced-reduction-in-motor-and-exploratory-activity-and-striatal-dopamine-d2-receptor-binding-in-the-rat
#5
Susanne Nikolaus, Markus Beu, Maria A de Souza Silva, Joseph P Huston, Hubertus Hautzel, Claudia Mattern, Christina Antke, Hans-Wilhelm Müller
PURPOSE: The present study assessed the influence of L-DOPA administration on neostriatal dopamine (DA) D2 receptor binding in relation to motor and exploratory behaviors in the rat. METHODS: D2 receptor binding was measured in baseline, after challenge with the aromatic L-amino acid decarboxylase inhibitor benserazide, and after challenge with either 5 or 10 mg/kg L-DOPA plus benserazide. Additional rats received injections of saline. For baseline and challenges, striatal equilibrium ratios (V[Formula: see text]) were computed as estimation of the binding potential...
2015: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/26746579/accumulation-of-iron-in-the-putamen-predicts-its-shrinkage-in-healthy-older-adults-a-multi-occasion-longitudinal-study
#6
Ana M Daugherty, Naftali Raz
Accumulation of non-heme iron is believed to play a major role in neurodegeneration of the basal ganglia. In healthy aging, however, the temporal relationship between change in brain iron content and age-related volume loss is unclear. Here, we present the first long-term longitudinal multi-occasion investigation of changes in iron content and volume in the neostriatum in a sample of healthy middle-aged and older adults (N=32; ages 49-83years at baseline). Iron content, estimated via R2* relaxometry, increased in the putamen, but not the caudate nucleus...
March 2016: NeuroImage
https://www.readbyqxmd.com/read/26590367/the-mao-b-inhibitor-deprenyl-reduces-the-oral-tremor-and-the-dopamine-depletion-induced-by-the-vmat-2-inhibitor-tetrabenazine
#7
Samantha J Podurgiel, Samantha E Yohn, Kristina Dortche, Merce Correa, John D Salamone
Tetrabenazine (TBZ) is prescribed for the treatment of chorea associated with Huntington's disease. Via inhibition of the vesicular monoamine transporter (VMAT-2), TBZ blocks dopamine (DA) storage and depletes striatal DA; this drug also has been shown to induce Parkinsonian motor side effects in patients. Recently, TBZ was shown to induce tremulous jaw movements (TJMs) in rats and mice. TJMs are an oral tremor that has many of the characteristics of Parkinsonian tremor in humans. The present study focused upon the ability of the well-established antiparkinsonian agent deprenyl to attenuate the behavioral and neurochemical effects of 2...
February 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26505142/structural-covariance-of-neostriatal-and-limbic-regions-in-patients-with-obsessive-compulsive-disorder
#8
Marta Subirà, Marta Cano, Stella J de Wit, Pino Alonso, Narcís Cardoner, Marcelo Q Hoexter, Jun Soo Kwon, Takashi Nakamae, Christine Lochner, João R Sato, Wi Hoon Jung, Jin Narumoto, Dan J Stein, Jesus Pujol, David Mataix-Cols, Dick J Veltman, José M Menchón, Odile A van den Heuvel, Carles Soriano-Mas
BACKGROUND: Frontostriatal and frontoamygdalar connectivity alterations in patients with obsessive-compulsive disorder (OCD) have been typically described in functional neuroimaging studies. However, structural covariance, or volumetric correlations across distant brain regions, also provides network-level information. Altered structural covariance has been described in patients with different psychiatric disorders, including OCD, but to our knowledge, alterations within frontostriatal and frontoamygdalar circuits have not been explored...
March 2016: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/26385010/children-s-intellectual-ability-is-associated-with-structural-network-integrity
#9
Dae-Jin Kim, Elysia Poggi Davis, Curt A Sandman, Olaf Sporns, Brian F O'Donnell, Claudia Buss, William P Hetrick
Recent structural and functional neuroimaging studies of adults suggest that efficient patterns of brain connectivity are fundamental to human intelligence. Specifically, whole brain networks with an efficient small-world organization, along with specific brain regions (i.e., Parieto-Frontal Integration Theory, P-FIT) appear related to intellectual ability. However, these relationships have not been studied in children using structural network measures. This cross-sectional study examined the relation between non-verbal intellectual ability and structural network organization in 99 typically developing healthy preadolescent children...
January 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/26256420/phosphodiesterase-10a-inhibitor-mp-10-pf-2545920-produces-greater-induction-of-c-fos-in-dopamine-d2-neurons-than-in-d1-neurons-in-the-neostriatum
#10
COMPARATIVE STUDY
Jonathan M Wilson, Ann Marie L Ogden, Sally Loomis, Gary Gilmour, Anthony J Baucum, Teri L Belecky-Adams, Kalpana M Merchant
Studies described here tested the hypothesis that phosphodiesterase 10A inhibition by a selective antagonist, MP-10, activates the dopamine D2 receptor expressing medium spiny neurons to a greater extent than the D1 receptor expressing neurons. We used regional pattern of c-Fos induction in the neostriatal subregions of rodents and direct assessment of D1-positive and -negative neurons in the DRd1a-tdTomato mice for the purpose. MP-10 (1, 3, 10 or 30 mg/kg, PO) dose-dependently increased c-Fos immunopositive nuclei in all regions of neostriatum...
December 2015: Neuropharmacology
https://www.readbyqxmd.com/read/26215117/gender-dependent-and-genotype-sensitive-monoaminergic-changes-induced-by-polychlorinated-biphenyl-153-in-the-rat-brain
#11
Kine S N Dervola, Espen B Johansen, S Ivar Walaas, Frode Fonnum
Polychlorinated biphenyls (PCBs) are present as ortho- and non-ortho-substituted PCBs, with most of the ortho-substituted congeners being neurotoxic. The present study examined effects of the ortho-substituted PCB 153 on dopamine, serotonin and amino acid neurotransmitters in the neostriatum of both male and female Wistar Kyoto (WKY) and spontaneously hypertensive rat (SHR) genotypes. PCB 153 exposure at p8, p14 and p20 had no effects on levels of these transmitters when examined at p55, but led to increased levels of both homovanillic acid and 5-hydroxyindoleacetic acid, the degradation products of dopamine and serotonin, respectively, in all groups except the female SHR...
September 2015: Neurotoxicology
https://www.readbyqxmd.com/read/25908399/dopaminergic-and-cholinergic-modulation-of-striatal-tyrosine-hydroxylase-interneurons
#12
Osvaldo Ibáñez-Sandoval, Harry S Xenias, James M Tepper, Tibor Koós
The recent electrophysiological characterization of TH-expressing GABAergic interneurons (THINs) in the neostriatum revealed an unexpected degree of diversity of interneurons in this brain area (Ibáñez-Sandoval et al., 2010, Unal et al., 2011, 2015). Despite being relatively few in number, THINs may play a significant role in transmitting and distributing extra- and intrastriatal neuromodulatory signals in the striatal circuitry. Here we investigated the dopaminergic and cholinergic regulation of THINs in vitro...
August 2015: Neuropharmacology
https://www.readbyqxmd.com/read/25865337/novel-fast-adapting-interneurons-mediate-cholinergic-induced-fast-gabaa-inhibitory-postsynaptic-currents-in-striatal-spiny-neurons
#13
Thomas W Faust, Maxime Assous, Fulva Shah, James M Tepper, Tibor Koós
Previous work suggests that neostriatal cholinergic interneurons control the activity of several classes of GABAergic interneurons through fast nicotinic receptor-mediated synaptic inputs. Although indirect evidence has suggested the existence of several classes of interneurons controlled by this mechanism, only one such cell type, the neuropeptide-Y-expressing neurogliaform neuron, has been identified to date. Here we tested the hypothesis that in addition to the neurogliaform neurons that elicit slow GABAergic inhibitory responses, another interneuron type exists in the striatum that receives strong nicotinic cholinergic input and elicits conventional fast GABAergic synaptic responses in projection neurons...
July 2015: European Journal of Neuroscience
https://www.readbyqxmd.com/read/25574457/effects-of-developmental-manganese-stress-and-the-combination-of-both-on-monoamines-growth-and-corticosterone
#14
Charles V Vorhees, Devon L Graham, Robyn M Amos-Kroohs, Amanda A Braun, Curtis E Grace, Tori L Schaefer, Matthew R Skelton, Keith M Erikson, Michael Aschner, Michael T Williams
Developmental exposure to manganese (Mn) or stress can each be detrimental to brain development. Here, Sprague-Dawley rats were exposed to two housing conditions and Mn from postnatal day (P)4-28. Within each litter two males and 2 females were assigned to the following groups: 0 (vehicle), 50, or 100 mg/kg Mn by oral gavage every other day. Half the litters were reared in cages with standard bedding and half with no bedding. One pair/group in each litter had an acute shallow water stressor before tissue collection (i...
2014: Toxicology Reports
https://www.readbyqxmd.com/read/25566000/relationship-between-l-dopa-induced-reduction-in-motor-and-exploratory-activity-and-degree-of-dat-binding-in-the-rat
#15
Susanne Nikolaus, Markus Beu, Angelica Maria De Souza Silva, Joseph P Huston, Hubertus Hautzel, Owen Y Chao, Christina Antke, Hans-Wilhelm Müller
PURPOSE: The present study assessed the influence of L-DOPA administration on neostriatal dopamine (DA) transporter (DAT) binding in relation to motor and exploratory behaviors in the rat. METHODS: Rats received injections of 5 mg/kg L-DOPA, 10 mg/kg L-DOPA or vehicle. Motor and exploratory behaviors were assessed for 30 min in an open field prior to administration of [(123)I]FP-CIT. Dopamine transporter binding was measured with small animal single-photon emission computed tomography (SPECT) 2 h after radioligand administration for 60 min...
2014: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/25063429/a-transgenic-minipig-model-of-huntington-s-disease
#16
Monika Baxa, Marian Hruska-Plochan, Stefan Juhas, Petr Vodicka, Antonin Pavlok, Jana Juhasova, Atsushi Miyanohara, Tetsuya Nejime, Jiri Klima, Monika Macakova, Silvia Marsala, Andreas Weiss, Svatava Kubickova, Petra Musilova, Radek Vrtel, Emily M Sontag, Leslie M Thompson, Jan Schier, Hana Hansikova, David S Howland, Elena Cattaneo, Marian DiFiglia, Martin Marsala, Jan Motlik
BACKGROUND: Some promising treatments for Huntington's disease (HD) may require pre-clinical testing in large animals. Minipig is a suitable species because of its large gyrencephalic brain and long lifespan. OBJECTIVE: To generate HD transgenic (TgHD) minipigs encoding huntingtin (HTT)1-548 under the control of human HTT promoter. METHODS: Transgenesis was achieved by lentiviral infection of porcine embryos. PCR assessment of gene transfer, observations of behavior, and postmortem biochemical and immunohistochemical studies were conducted...
2013: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/25023309/investigation-of-synaptic-microcircuits-using-patch-clamp-paired-recordings-in-acute-brain-slices
#17
Giovanni Russo, Stefano Taverna
Multiple patch clamp recordings represent a powerful tool to investigate functional synaptic connectivity among individual cells. This technical approach is particularly useful to study the synaptic organization of microcircuits in certain brain areas, e.g., the striatum, which are characterized by heterogeneous cell populations and an apparent lack of an anatomically ordered cytoarchitecture. Fast-spiking interneurons (FSIs) represent less than 1 % of striatal neurons, but despite their rareness they exert a strong influence on signal processing by striatal microcircuits and principal cells output...
2014: Methods in Molecular Biology
https://www.readbyqxmd.com/read/24706558/novel-tubb4a-mutations-and-expansion-of-the-neuroimaging-phenotype-of-hypomyelination-with-atrophy-of-the-basal-ganglia-and-cerebellum-h-abc
#18
REVIEW
Carlos Ferreira, Andrea Poretti, Julie Cohen, Ada Hamosh, Sakkubai Naidu
Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) has recently been associated with a single heterozygous p.D249N mutation in TUBB4A. We describe two novel mutations in this gene. A p.C239F mutation was found in one of the originally described H-ABC patients, for whom we provide follow-up 11 years after the original publication. The second novel mutation, p.R262H, was found in a patient with a typical clinical presentation for H-ABC, but with a novel neuroimaging phenotype, given the absence of atrophy of the putamen and caudate nucleus despite 7 years of follow-up...
July 2014: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/24685534/neuroprotective-effects-of-hypothermia-on-synaptic-actin-cytoskeletal-changes-induced-by-perinatal-asphyxia
#19
Javier Muñiz, Juan Romero, Mariana Holubiec, George Barreto, Janneth González, Madeleine Saint-Martin, Eduardo Blanco, Juan Carlos Cavicchia, Rocío Castilla, Francisco Capani
Cerebral hypoxia-ischemia damages synaptic proteins, resulting in cytoskeletal alterations, protein aggregation and neuronal death. In the previous works, we have shown neuronal and synaptic changes in rat neostriatum subjected to hypoxia that leads to ubi-protein accumulation. Recently, we also showed that, changes in F-actin organization could be related to early alterations induced by hypoxia in the Central Nervous System. However, little is known about effective treatment to diminish the damage. The main aim of this work is to study the effects of birth hypothermia on the actin cytoskeleton of neostriatal post-synaptic densities (PSD) in 60 days olds rats by immunohistochemistry, photooxidation and western blot...
May 14, 2014: Brain Research
https://www.readbyqxmd.com/read/24486731/neurochemical-dysfunction-in-treated-and-nontreated-schizophrenia-a-retrospective-analysis-of-in-vivo-imaging-studies
#20
REVIEW
Susanne Nikolaus, Hubertus Hautzel, Hans-Wilhelm Müller
To evaluate the contribution of individual synaptic constituents, all available in vivo imaging studies on schizophrenic patients were subjected to a retrospective analysis. For the pool of drug-naïve, drug-free, and acutely medicated patients, major findings were increases in neostriatal dopamine (DA) synthesis and release and decreases in neostriatal DA transporters and D1 receptors, neostriatal, thalamic, frontal, and parietal D2 receptors, mesencephalic/pontine and temporal 5-HT1A receptors, frontal and temporal HT2A and μ-amino butyric acid (GABA)A receptors...
2014: Reviews in the Neurosciences
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