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luteinizing hormones

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https://www.readbyqxmd.com/read/28723610/pediatric-reference-intervals-for-29-ortho-vitros-5600-immunoassays-using-the-caliper-cohort-of-healthy-children-and-adolescents
#1
Victoria Higgins, Angela W S Fung, Man Khun Chan, Joseph Macri, Khosrow Adeli
BACKGROUND: Accurate reference intervals (RIs) based on a healthy pediatric population are essential for pediatric test result interpretation. The CALIPER project has recruited a large healthy cohort and completed a series of a priori studies to address gaps in pediatric RIs. As immunoassays from different manufacturers for endocrine and special chemistry markers are not standardized and show marked intermethod differences, direct RI studies are needed for each major analytical platform...
July 19, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28721614/low-doses-of-chlorpyrifos-interfere-with-spermatogenesis-of-rats-through-reduction-of-sex-hormones
#2
Dinithi Champika Peiris, Thamali Dhanushka
Use of pesticides results in indirect effects on human health. We aimed to evaluate implications of toxicological effects of subchronic chlorpyrifos exposure on reproductive function in male rats. A total of 48 adult Wistar male rats were separated into four groups (n = 12). Animals were gavaged with 2.5 mg/kg (T1), 5 mg/kg (T2), or 10 mg/kg (T3) body weight of chlorpyrifos (CPF) or distilled water (control) daily for 30 days. Organ weights, epididymal sperm parameters, DNA integrity, sex hormonal (FHS and LH) levels, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), and creatinine concentrations were determined on day 31...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28720645/influences-of-manganese-on-pubertal-development
#3
W Les Dees, Jill K Hiney, Vinod K Srivastava
The onset of puberty is the result of complex neuroendocrine interactions within hypothalamic region of the brain, as well as from genetic and environmental influences. These interactions ultimately result in the increased synthesis and release of luteinizing hormone- releasing hormone (LHRH). Manganese (Mn) is an essential environmental element known for years to be involved in numerous mammalian physiological processes, including growth and reproductive function. Studies in recent years have shown the ability of Mn to cross the blood-brain barrier and act within the hypothalamus to influence the timing of puberty...
July 18, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28716370/a-systematic-review-and-framework-for-the-use-of-hormone-therapy-with-salvage-radiation-therapy-for-recurrent-prostate-cancer
#4
REVIEW
Daniel E Spratt, Robert T Dess, Zachary S Zumsteg, Daniel W Lin, Phuoc T Tran, Todd M Morgan, Emmanuel S Antonarakis, Paul L Nguyen, Charles J Ryan, Howard M Sandler, Matthew R Cooperberg, Edwin Posadas, Felix Y Feng
CONTEXT: Salvage radiotherapy (SRT) is a standard of care for men who recur postprostatectomy, and recent randomized trials have assessed the benefit and toxicity of adding hormone therapy (HT) to SRT with differing results. OBJECTIVE: To perform a systematic review of randomized phase III trials of the use of SRT ± HT and generate a framework for the use of HT with SRT. EVIDENCE ACQUISITION: Systematic literature searches were conducted on February 15, 2017 in three databases (MEDLINE [via PubMed], EMBASE, and ClinicalTrials...
July 14, 2017: European Urology
https://www.readbyqxmd.com/read/28715966/protective-effects-of-human-chorionic-gonadotropin-against-breast-cancer-how-can-we-use-this-information-to-prevent-treat-the-disease
#5
C V Rao
Breast cancers (BCs) are the most common malignancies among women worldwide. Giving birth to a first child before 24 years of age decreases the BC risk by about half, when women reach menopausal years. The scientific evidence suggests that the actions of human chorionic gonadotropin (hCG) are responsible for this decrease. Human BC cells and tissues contain hCG/luteinizing hormone receptors. The activation of the receptors results in an increase in cell differentiation and apoptosis. Conversely, it decreases the cell proliferation, invasion, and survival...
August 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28713816/effect-of-the-camelid-s-seminal-plasma-ovulation-inducing-factor-%C3%AE-ngf-a-kisspeptin-target-hypothesis
#6
REVIEW
Khalid El Allali, Najlae El Bousmaki, Hassan Ainani, Valérie Simonneaux
Female mammals are classified into spontaneous and induced ovulators based on the mechanism eliciting ovulation. Ovulation in spontaneous species (e.g., human, sheep, cattle, horse, pigs, and most rodents) occurs at regular intervals and depends upon the circulating estradiol. However, in induced ovulators (e.g., rabbits, ferrets, cats, and camelids), ovulation is associated with coitus. In the later, various factors have been proposed to trigger ovulation, including auditory, visual, olfactory, and mechanic stimuli...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28712786/the-relationship-between-hot-flashes-and-testosterone-recovery-after-12-months-of-androgen-suppression-for-men-with-localised-prostate-cancer-in-the-ascende-rt-trial
#7
M Dosani, W J Morris, S Tyldesley, T Pickles
AIMS: This study describes the proportion of men who experienced hot flashes (flashes), and the testosterone level at onset, peak frequency and cessation of flashes after 12 months of androgen deprivation therapy (ADT) in men undergoing curative-intent external beam radiation therapy (± brachytherapy boost). We also aimed to characterise testosterone recovery in this population. MATERIALS AND METHODS: This was a pre-specified secondary analysis of the ASCENDE-RT clinical trial...
July 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28712426/negative-affect-is-unrelated-to-fluctuations-in-hormone-levels-across-the-menstrual-cycle-evidence-from-a-multisite-observational-study-across-two-successive-cycles
#8
Michael P Hengartner, Tillmann H C Kruger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Susanna Röblitz, Rainald Ehrig, Lanja Saleh, Katharina Spanaus, Cordula Schippert, Yuanyuan Zhang, Brigitte Leeners
BACKGROUND: Female sex hormones may play a crucial role in the occurrence of cycle-related mood disorders. However, the literature is inconsistent and methodologically stringent observational studies on the relationship between sex hormones and negative affect are lacking. METHODS: In this longitudinal multisite study from Hannover, Germany, and Zurich, Switzerland, we examined oestrogen, progesterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels in association with negative affect as measured with the Positive and Negative Affect Schedule (PANAS)...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28711266/intravaginal-instillation-of-gonadotropin-releasing-hormone-analogues-with-an-absorption-enhancer-induced-a-surge-of-luteinizing-hormone-in-lactating-dairy-cows
#9
R Wijma, M L Stangaferro, M Masello, M A Elmetwally, G E Granados, F Amovilli, J O Giordano
Our objectives were to evaluate circulating LH concentrations after intravaginal (IVG) instillation of GnRH analogs in lactating dairy cows. In 2 experiments, lactating Holstein cows (experiment 1: n = 32; experiment 2: n = 47) received the experimental treatments 48 h after the first of 2 PGF2α treatments given 12 h apart and 7 d after a modified Ovsynch protocol (GnRH at -7 d, PGF2α at -24 h, PGF2α at -56 h, GnRH at 0 h). In experiment 1, cows were stratified by parity and randomly allocated to receive the following treatments: 2 mL of saline IVG (SAL, n = 6), 100 µg of gonadorelin (Gon) i...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28711070/female-adolescents-with-chronic-or-end-stage-kidney-disease-and-strategies-for-their-care
#10
Maria E Diaz-Gonzalez De Ferris, Ana Catalina Alvarez-Elías, Michael Ted Ferris, Mara Medeiros
The prevalence of chronic or end-stage kidney disease in pediatric girls is lower than in boys, however, girls have unique morbidities that can have great effect on their quality of life. For female adolescents, creatinine excretion peaks at approximately 14 years of age and is significantly less than males, owing to lower muscle mass. Females have higher nitric oxide activity, and estrogens may contribute to lower blood pressure. Females excrete less growth hormone during the prepubertal and pubertal years...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28708501/bmal1-interference-impairs-hormone-synthesis-and-promotes-apoptosis-in-porcine-granulosa-cells
#11
Wusu Wang, Lin Yin, Long Bai, Guangjun Ma, Cunzhen Zhao, Aoqi Xiang, Weijun Pang, Gongshe Yang, Guiyan Chu
In mammals, granulosa cell proliferation, differentiation, luteinization, apoptosis, and hormone synthesis are tightly related to oocyte maturation, follicular development and ovarian function. In current study, we investigated the role of the key circadian clock gene, brain and muscle arnt-like protein-1 (Bmal1), on porcine granulosa cell hormone secretion and apoptosis. The transcription levels of circadian clock genes, including Bmal1 and period circadian clock 2 (Per2), were detected by RT-qPCR. We found that the circadian clock genes exhibited rhythmic change and were further enhanced by dexamethasone synchronization in granulosa cells...
May 23, 2017: Theriogenology
https://www.readbyqxmd.com/read/28707810/curative-effect-of-1-88-mg-and-3-75-mg-gonadotrophin-releasing-hormone-agonist-on-stage-iii-iv-endometriosis-randomized-controlled-study
#12
Huiru Tang, Ruifang Wu, Xiaohong Li, Yanqiu Zhou, Zhihong Liu, Chun Wang, Yun Chen, Fangting Zhang
AIM: To compare the therapeutic effect of 1.88-mg and 3.75-mg gonadotrophin-releasing hormone agonist (GnRHa) in the treatment of stage III-IV endometriosis after laparoscopic surgery. METHODS: Fifty patients with stage III-IV endometriosis diagnosed on laparoscopy were randomized into two groups according to GnRHa dose. Sex hormone level, symptoms of estrogen deficiency and lumbar vertebrae bone density were compared and analyzed between the two groups. RESULTS: Bone density was decreased in both groups at 20 weeks after treatment, and the degree of bone density loss in the full-dose group (5...
July 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28706612/polymorphisms-in-the-estrogen-receptor-beta-gene-and-the-risk-of-unexplained-recurrent-spontaneous-abortion
#13
Marzieh Mahdavipour, Saeed Zarei, Ramina Fatemi, Haleh Edalatkhah, Hamed Heidari-Vala, Mahmood Jeddi-Tehrani, Farah Idali
BACKGROUND: Recurrent Spontaneous Abortion (RSA) is caused by multiple genetic and non-genetic factors. Around 50% of the RSA cases have no known etiology and are considered as Unexplained RSA (URSA). Estrogens, via binding to their receptors, play an important role in female reproduction. This study aimed to investigate whether single nucleotide polymorphisms (SNPs; +1082G/A, +1730G/A and rs1256030 C/T) in the estrogen receptor beta (ESR2) gene are associated with susceptibility to URSA in a population of Iranian women...
July 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28702774/do-fsh-lh-ratio-and-gonadal-hormone-levels-predict-clinical-improvement-in-postmenopausal-schizophrenia-women
#14
Alexandre González-Rodríguez, Miquel Bernardo, Rafael Penadés, Bárbara Arias, Victoria Ruiz Cortés, Mary V Seeman, Rosa Catalán
Menopause is a process characterized by a decline in estrogen levels and is therefore a period of biological vulnerability for psychotic relapse in women with schizophrenia. Our goal was to correlate not only gonadal hormone levels but also follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels with improvement in specific clinical symptoms. Thirty-seven acutely ill postmenopausal schizophrenia women with a newly initiated, clinically determined change in antipsychotic medication participated in a 12-week prospective observational outcome study...
July 12, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28701961/insights-into-the-development-of-the-adult-leydig-cell-lineage-from-stem-leydig-cells
#15
REVIEW
Leping Ye, Xiaoheng Li, Linxi Li, Haolin Chen, Ren-Shan Ge
Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers, including luteinizing hormone (LH) receptor and 3β-hydroxysteroid dehydrogenase. The commitment of SLCs into the progenitor Leydig cells (PLCs), the first stage in the lineage, requires growth factors, including Dessert Hedgehog (DHH) and platelet-derived growth factor-AA...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28699305/enhancement-of-the-lh-surge-by-male-olfactory-signals-is-associated-with-avpv-kiss1-cell-activation-in-female-rats
#16
Youki Watanabe, Kana Ikegami, Ren Ishigaki, Nahoko Ieda, Yoshihisa Uenoyama, Kei-Ichiro Maeda, Hiroko Tsukamura, Naoko Inoue
Olfactory stimuli play an important role in regulating reproductive functions in mammals. The present study investigated the effect of olfactory signals derived from male rats on kisspeptin neuronal activity and luteinizing hormone (LH) secretion in female rats. Wistar-Imamichi strain female rats were ovariectomised (OVX) and implanted with preovulatory levels of oestradiol-17β (E2). OVX+E2 rats were sacrificed 1 hour after exposure to either: clean bedding, female-soiled bedding or male-soiled bedding. Dual staining for Kiss1 mRNA in situ hybridization and c-Fos immunohistochemistry revealed that the numbers of Kiss1-expressing cells and c-Fos-immunopositive Kiss1-expressing cells in the anteroventral periventricular nucleus (AVPV) were significantly higher in OVX+E2 rats exposed to male-soiled bedding than those of the other groups...
July 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28699196/cytokeratin-positive-folliculo-stellate-cells-in-chicken-adenohypophysis
#17
Shotaro Nishimura, Miyu Yamashita, Takane Kaneko, Fuminori Kawabata, Shoji Tabata
Folliculo-stellate (FS) cells are non-endocrine cells found in the adenohypophysis and are identified in many animals by the S100 protein marker. Although keratin is another FS marker in several animals, there is no information on localization of keratin in the avian adenohypophysis. In this study, localization of cytokeratin in chicken adenohypophyseal cells was investigated immunohistochemically. Basic cytokeratin (bCK)-positive cells were arranged radially in the cell cords with their cytoplasmic processes reaching the basal lamina...
July 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28697822/-diagnostic-value-of-baseline-serum-luteinizing-hormone-level-for-central-precocious-puberty-in-girls
#18
Li-Xue Ou-Yang, Fan Yang
OBJECTIVE: To evaluate the diagnostic value of baseline serum luteinizing hormone (LH) level for central precocious puberty (CPP) in girls. METHODS: A total of 279 girls with precocious puberty were subjected to assessment of growth and development, bone age determination, baseline LH test, and follicle-stimulating hormone (FSH) test, gonadotropin-releasing hormone stimulation test, and other related examinations. Of the 279 patients, 175 were diagnosed with CPP and 104 with premature thelarche (PT)...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28695963/differential-regulation-of-cumulus-cell-transcription-during-oocyte-maturation-in-vivo-and-in-vitro
#19
Giovanni Coticchio, Libby Ophir, Yuval Yung, Micha Baum, Mariabeatrice Dal Canto, Mario Mignini-Renzini, Fausta Brambillasca, Rubens Fadini, Ariel Hourvitz
Differences in cumulus cell gene expression after oocyte maturation in vitro (IVM) or in vivo have been described in previous studies. However, the possible impact of follicle stage on gene expression deregulation during human oocyte IVM remains unknown. Expression of selected genes of interest was compared in cumulus cell of three classes of human cumulus cell-oocyte complexes (COCs): a) COCs derived from human chorionic gonadotropin (hCG)-triggered IVM cycles, collected at the germinal vesicle (GV) stage from mid-sized follicles (4-12 mm) and matured in vitro (IVM-GV); b) COCs derived from hCG-triggered IVM cycles, collected from mid-sized follicles (4-12 mm) and matured in vivo (IVM-MII); c) COCs derived from controlled ovarian stimulation in vitro fertilization (IVF) cycles, collected from large/preovulatory follicles and matured in vivo (IVF-MII)...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28693207/-99m-tc-lhrh-in-tumor-receptor-imaging
#20
Dawei Hao, Lingfei Sun, Xiang Hu, Xiaowen Hao
Detection of gonadotropin-releasing hormone (GnRH) also known as luteinizing hormone-releasing hormone (LHRH) in the relevant tumor tissue and normal tissues and organs in vivo expression was investigated. To examine the method of direct radio labeling of LHRH by (99m)Tc with relatively high radiochemical purity and stability, screening the best labeling conditions, to establish a simple and reliable method of preparation of (99m)Tc-LHRH was undertaken. The detection of radioisotope-labeled LHRH distribution in mice, LHRH receptor imaging for the study and treatment of cancer basis were evaluated...
July 2017: Oncology Letters
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