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luteinizing hormones

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https://www.readbyqxmd.com/read/28933574/is-there-a-role-for-kisspeptin-in-pathogenesis-of-polycystic-ovary-syndrome
#1
Umit Gorkem, Cihan Togrul, Emine Arslan, Ayla Sargin Oruc, Nuriye Buyukkayaci Duman
AIM: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. MATERIALS AND METHODS: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28931393/successful-pregnancy-and-live-birth-from-a-hypogonadotropic-hypogonadism-woman-with-low-serum-estradiol-concentrations-despite-numerous-oocyte-maturations-a-case-report
#2
Kaori Matsumoto, Kazuhiko Imakawa, Chuyu Hayashi
BACKGROUND: The increase in serum estradiol (E2) concentrations during the follicular phase becomes the index of oocyte maturation in vivo. When ovarian stimulation is performed to hypogonadotropic hypogonadism (HH) patients with only follicle stimulating hormone (FSH), proper increase in serum E2 concentrations is not observed. Even if oocytes are obtained, which usually have low fertilization rate. In this report, we would like to present an unique case, in which under low E2 concentrations and without luteinizing hormone (LH) administration, numerous mature oocytes could be obtained and a healthy baby delivered...
September 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28930160/human-chorionic-gonadotrophin-as-a-possible-mediator-of-leiomyoma-growth-during-pregnancy-molecular-mechanisms
#3
REVIEW
Veronica Sarais, Greta Chiara Cermisoni, Matteo Schimberni, Alessandra Alteri, Enrico Papaleo, Edgardo Somigliana, Paola Vigano'
Uterine fibroids are the most common gynecologic benign tumors. Studies supporting a strong pregnancy-related growth of leiomyomas generally claimed a crucial role of sex steroid hormones. However, sex steroids are unlikely the unique actors involved as estrogen and progesterone achieve a pick serum concentration in the last trimester while leiomyomas show a typical increase during the first trimester. Given the rapid exponential raise in serum human Chorionic Gonadotrophin (hCG) at the beginning of gestation, we conducted a review to assess the potential role of hCG in the striking growth of leiomyomas during initial pregnancy...
September 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28929602/chromium-supplementation-in-women-with-polycystic-ovary-syndrome-systematic-review-and-meta-analysis
#4
Xiao-Lei Tang, Zheng Sun, Lei Gong
AIM: Increasing evidence has suggested that chromium supplementation may improve the clinical symptoms of polycystic ovary syndrome (PCOS), yet the results have been inconsistent. To derive a more precise estimation of the efficacy of chromium, a meta-analysis was performed. METHODS: Studies published in PubMed, EMBASE and the Cochrane Library up to April 2017 were retrieved. Standardized mean differences (SMD) with 95%CI were calculated for net changes using random-effects or fixed-effects models...
September 20, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28920796/successful-laparoscopic-oviductal-artificial-insemination-in-the-clouded-leopard-neofelis-nebulosa-in-thailand
#5
Wanlaya Tipkantha, Paweena Thuwanut, Umaporn Maikeaw, Ampika Thongphakdee, Saifon Yapila, Sumate Kamolnorranath, Boripat Siriaroonrat, Pierre Comizzoli, Kaywalee Chatdarong
Captive breeding of clouded leopards (Neofelis nebulosa) is challenging because of mating incompatibility, high incidence of teratospermia in males, and inconsistent ovulation patterns in females. Assisted reproductive techniques, therefore, are necessary to overcome these issues and maintain the genetic diversity in the captive population. The objective was to use laparoscopic oviductal artificial insemination (AI) to breed genetically valuable females (n = 4; aged 4.5-5 yr) that were unsuccessfully paired...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28920406/evaluation-of-high-nutrient-diets-on-litter-performance-of-heat-stressed-lactating-sows
#6
Yohan Choi, Abdolreza Hosseindoust, Minju Kim, Alip Kumar, Seungmin Oh, Young Hwa Kim, Byung Jo Chae
Objective: The present study investigated the litter performance of multiparous sows fed 3% and 6% densified diets at farrowing to weaning during summer with mean maximum room temperature of 30.5°C. Methods: A total of 60 crossbred multiparous sows were allotted to one of three treatments based on body weight according to a completely randomized design. Three different nutrient levels based on NRC were applied as standard diet (ST; ME, 3300 kcal/kg), high nutrient level 1 (HE1; ST + 3% higher energy and 16...
September 18, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28914097/advanced-glycation-end-products-interfere-in-luteinizing-hormone-and-follicle-stimulating-hormone-signaling-in-human-granulosa-kgn-cells
#7
Eleni A Kandaraki, Antonios Chatzigeorgiou, Efstathia Papageorgiou, Christina Piperi, Christos Adamopoulos, Athanasios G Papavassiliou, Michael Koutsilieris, Evanthia Diamanti-Kandarakis
Advanced glycation end products accumulate in the ovarian granulosa-cell layer of women with polycystic ovarian syndrome. Taken that the MAPK/ERK-pathway is a key regulator of oocyte maturation and function, consisting the main pathway used by the gonadotrophic hormones (luteinizing hormone, follicle stimulating hormone) to control ovulation, the present study aims to assess advanced glycation end products' interference into luteinizing hormone-and follicle stimulating hormone-signaling via the MAPK/ERK-pathway in the human granulosa KGN cell line...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28912339/reproductive-and-metabolic-features-during-puberty-in-sons-of-women-with-polycystic-ovary-syndrome
#8
Nicolas Crisosto, Barbara Echiburú, Manuel Maliqueo, Marta Luchsinger, Pedro Rojas, Sergio Recabarren, Teresa Sir-Petermann
CONTEXT: Intrauterine life may be implicated in the origin of polycystic cvary syndrome (PCOS) modifying the endocrine and metabolic function of children born to PCOS mothers independently of the genetic inheritance and gender. The aim of the present study was to evaluate the reproductive and metabolic function in sons of women with PCOS during puberty. METHODS: Sixty nine PCOSs and 84 control sons (Cs) 7 to 18 years old matched by Tanner stage score were studied...
September 14, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28912046/seasonal-expression-of-luteinizing-hormone-receptor-and-follicle-stimulating-hormone-receptor-in-testes-of-the-wild-ground-squirrels-citellus-dauricus-brandt
#9
Junjie Wang, Ying Wang, Manyu Zhu, Fengwei Zhang, Xia Sheng, Haolin Zhang, Yingying Han, Zhengrong Yuan, Qiang Weng
The objective of this study was to evaluate whether luteinizing hormone (LH), follicle stimulating hormone (FSH) and their receptors luteinizing hormone receptor (LHR) and follicle stimulating hormone receptor (FSHR) play roles in the seasonal spermatogenesis of the wild ground squirrels. To that end, we characterized the testicular immunolocalization of LHR and FSHR, their expression on both mRNA and protein levels, as well as serum concentrations of LH and FSH in male wild ground squirrels throughout the annual reproductive cycle...
September 11, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28911176/new-insights-into-the-role-of-estrogens-in-male-fertility-based-on-findings-in-aromatase-deficient-zebrafish
#10
Haipei Tang, Yu Chen, Yun Liu, Yike Yin, Gaofei Li, Yin Guo, Xiaochun Liu, Haoran Lin
It has been demonstrated that estrogens are indispensable for male fertility in mammals. Aromatase (encoded by CYP19) catalyzes the final step of estradiol biosynthesis. However, less is known about the role of aromatase in male fertility in nonmammalian species. Fish aromatase is encoded by two separate genes: the gonad-specific cyp19a1a and the brain-specific cyp19a1b. In a recent study, we used transcription activatorlike effector nucleases to systematically generate cyp19a1a and cyp19a1b mutant lines and a cyp19a1a;cyp19a1b double-mutant line in zebrafish and demonstrated that cyp19a1a was indispensable for sex differentiation...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28904502/antispermatogenic-mechanism-of-trona-is-associated-with-lipid-peroxidation-but-not-testosterone-suppression
#11
Ayodeji F Ajayi, Roland E Akhigbe
BACKGROUND: About half of the cases of infertility in couples have been attributed to male factor. Despite the claim in folklore medicine that trona (a sesquicarbonate or hydrated carbonate of sodium) causes fetal loss, its effect on male reproductive function has not been investigated. AIM: This study sought to provide scientific evidence on the effect of trona on sperm characteristics, male reproductive hormones and organs, and lipid peroxidation. MATERIALS AND METHODS: Forty male Wistar rats of comparable weights were used for the study...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28904496/serum-amh-level-to-predict-the-hyper-response-in-women-with-pcos-and-non-pcos-undergoing-controlled-ovarian-stimulation-in-art
#12
Radha Vembu, Nellepalli Sanjeeva Reddy
BACKGROUND: It is essential to determine the cut-off value of serum anti-Mullerian hormone (AMH) to predict the hyper response in assisted reproductive technology (ART). There are few studies mentioning the cut-off value for the hyper response in infertile women but not specifically for polycystic ovary syndrome (PCOS) and non-PCOS groups. With this in background, this study was conducted. AIM: To determine the cut-off value of serum AMH to predict the hyper response in women with PCOS and non-PCOS undergoing a controlled ovarian stimulation (COS) in ART...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28903472/gnrh-antagonist-versus-long-agonist-protocols-in-ivf-a-systematic-review-and-meta-analysis-accounting-for-patient-type
#13
C B Lambalk, F R Banga, J A Huirne, M Toftager, A Pinborg, R Homburg, F van der Veen, M van Wely
BACKGROUND: Most reviews of IVF ovarian stimulation protocols have insufficiently accounted for various patient populations, such as ovulatory women, women with polycystic ovary syndrome (PCOS) or women with poor ovarian response, and have included studies in which the agonist or antagonist was not the only variable between the compared study arms. OBJECTIVE AND RATIONALE: The aim of the current study was to compare GnRH antagonist protocols versus standard long agonist protocols in couples undergoing IVF or ICSI, while accounting for various patient populations and treatment schedules...
September 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28894900/interaction-between-luteinizing-hormone-releasing-hormone-and-gm1-doped-cholesterol-sphingomyelin-vesicles-a-spectroscopic-study
#14
Zarrin Shahzadi, Chaitali Mukhopadhyay
Understanding the role of neural membrane in translocation and action of neurohormone is of great importance. Luteinizing hormone-releasing hormone (LHRH) is a neuropeptide hormone and it acts as a final signaling molecule by stimulating the synthesis of LH and FSH to maintain reproduction in all vertebrates. The receptors of LHRH are found in breast tumors and pituitary gland in the brain. Moreover, neural plasma membrane is also found to contain specific binding site for LHRH. The mechanism by which LHRH binds to membrane before it binds to the receptors is a very critical step and can have a profound impact upon the translation of peptide across the membrane...
September 11, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28887616/amitriptyline-plays-important-roles-in-modifying-the-ovarian-morphology-and-improving-its-functions-in-rats-with-estradiol-valerate-induced-polycystic-ovary
#15
Xinqiang Li, Shufen Wang, Li Zhang, Lei Zhang, Jiali Liu, Haoshu Luo, Kemian Gou, Sheng Cui
Previous studies demonstrated that depression is more prevalent in women with polycystic ovary syndrome (PCOS). In this study, we aimed to determine whether amitriptyline (AMT), an antidepressant drug, plays a role in preventing PCOS. The results showed that AMT modified ovarian morphology improved the ovarian functions and estrus cycle in estradiol valerate (EV)-induced polycystic ovary (PCO). AMT restored the levels of estradiol (E2), testosterone (T) and progesterone (P4) to normal, and elevated the level of luteinizing hormone (LH) in EV-induced PCO...
September 8, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28887327/uterine-flushings-from-women-treated-with-levonorgestrel-affect-sperm-functionality-in-vitro
#16
Mayel Chirinos, Marta Durand, María Elena González-González, Gabriela Hernández-Silva, Israel Maldonado-Rosas, Pablo Lopez, Fernando Larrea
Levonorgestrel (LNG), a synthetic 19 nor-testosterone derivative, is widely used for emergency contraception. It is well known that LNG prevents ovulation only when given prior to the surge of serum luteinizing hormone (LH) during the periovulatory phase of the menstrual cycle. This observation suggests that LNG, given its contraceptive efficacy, has additional effects other than those affecting ovulation. In this study, we have evaluated the effects on human sperm functionality of uterine flushings (UF) obtained from women at day LH+1 of a control cycle (CTR-LH+1) and after receiving LNG (LNG-LH+1) two days before the surge of LH...
September 8, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28878336/effect-of-gnrhr-polymorphisms-on-in-vitro-fertilization-and-embryo-transfer-in-patients-with-polycystic-ovary-syndrome
#17
Wei-Yan Chen, Yan-Qiu Du, Xia Guan, Hong-Yun Zhang, Ting Liu
We investigated the relationship between gonadotropin-releasing hormone receptor (GnRHR) gene polymorphisms and outcome of patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET). PCOS patients undergoing IVF-ET were selected, and infertile patients due to dysfunctional oviducts served as controls. GnRHR gene polymorphisms were detected using the polymerase chain reaction-restriction fragment length polymorphism assay. Gene-gene interaction and linkage disequilibrium tests were performed using the SHEsis software...
September 7, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28877731/hypoluteoidism-in-a-dog-associated-with-recurrent-mammary-fibroadenoma-stimulated-by-progestin-therapy
#18
Maria Teresa Zedda, Luisa Bogliolo, Elisabetta Antuofermo, Laura Falchi, Federica Ariu, Giovanni Pietro Burrai, Salvatore Pau
BACKGROUND: Hypoluteoidism in the bitch is characterized by insufficient production and secretion of progesterone by the corpora lutea. It is a rare pathologic condition and during pregnancy, it leads to embryonic resorption or fetal abortion. Supplementary therapy with progestins is indicated during pregnancy to obtain delivery of vital puppies but unwarranted side effects of such treatment are poorly documented. CASE PRESENTATION: A 4-year-old, nulliparous, female Istrian Shorthaired Hound dog had been mated repeatedly in six heats with different dogs of proven fertility but signs of pregnancy did not develop...
September 6, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28875319/kisspeptin-expression-features-in-the-arcuate-and-anteroventral-periventricular-nuclei-of-hypothalamus-of-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#19
Elham Aliabadi, Mohammad Reza Namavar, Keywan Mortezaee, Heidar Toolee, Sara Keshtgar, Hossein Mirkhani, Mohammad Akbari, Tayebeh Rastegar, Somayeh Solhjoo
PURPOSE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the reproductive system characterized by polycystic ovaries and androgen excess. Letrozole is a nonsteroidal aromatase inhibitor that is used in experimental research to induce PCOS. Kisspeptin is an essential protein in regulation of cyclicity. Kisspeptin receptor is expressed in the hypothalamus and pituitary glands, and kisspeptin containing neurons are affected from sex steroid hormones. We aimed to investigate the number of kisspeptin-positive cells in the arcuate (Arc) and anteroventral periventricular nuclei (AVPV) of hypothalamus in the letrozole-induced PCOS...
September 5, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28872086/-subclinical-hypothyroidism-and-endocrine-metabolic-characteristics-in-women-with-polycystic-ovary-syndrome
#20
Fangzhi Yue, Dongmei Zhang, Fei Gong, Li Zhang, Zhixiang Sun, Minxiang Lei
To explore associations of subclinical hypothyroidism (SCH) with endocrine metabolic characteristics in women with polycystic ovary syndrome (PCOS).
 Methods: A total of 321 women who were newly diagnosed as PCOS were recruited from two endocrine outpatient clinics. The diagnosis of PCOS was established according to the 2003 Rotterdam consensus criteria. Thyroid function was examined by chemiluminescent immunoassay. Patients who had normal free thyroxine (FT4) were divided into different SCH subgroups according to two thyroid stimulating hormone (TSH) cutoff points (4...
August 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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