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https://www.readbyqxmd.com/read/27796107/prevalence-of-lung-lesions-in-slaughtered-cattle-in-the-eastern-cape-province-south-africa
#1
Ishmael F Jaja, Borden Mushonga, Ezekiel Green, Voster Muchenje
Information obtained from abattoirs on the causes of lung condemnation is important in preventing the spread of zoonotic diseases and for promoting food security. In this study, we assessed the causes of lung condemnation in cattle at three abattoirs represented as ANA, QTA and EBA to evaluate the financial losses associated with lung condemnation. A retrospective study (n = 51 302) involving the use of abattoir slaughter records of 2010-2012 and an active abattoir survey (n = 1374) was conducted from July to December 2013...
October 26, 2016: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/27751868/microfluidic-platform-for-electrophysiological-recordings-from-host-stage-hookworm-and-ascaris-suum-larvae-a-new-tool-for-anthelmintic-research
#2
Janis C Weeks, William M Roberts, Kristin J Robinson, Melissa Keaney, Jon J Vermeire, Joseph F Urban, Shawn R Lockery, John M Hawdon
The screening of candidate compounds and natural products for anthelmintic activity is important for discovering new drugs against human and animal parasites. We previously validated in Caenorhabditis elegans a microfluidic device ('chip') that records non-invasively the tiny electrophysiological signals generated by rhythmic contraction (pumping) of the worm's pharynx. These electropharyngeograms (EPGs) are recorded simultaneously from multiple worms per chip, providing a medium-throughput readout of muscular and neural activity that is especially useful for compounds targeting neurotransmitter receptors and ion channels...
September 15, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27691948/radiographic-thoracic-anatomy-of-the-red-panda-ailurus-fulgens
#3
Modesta Makungu, Wencke M du Plessis, Michelle Barrows, Hermanus B Groenewald, Katja N Koeppel
The red panda ( Ailurus fulgens ) is classified as an endangered species by the International Union for Conservation of Nature and Natural Resources. The natural distribution of the red panda is in the Himalayas and southern China. Thoracic diseases such as dirofilariasis, hypertrophic cardiomyopathy, tracheal obstruction, lung worm infestation, and pneumonia have been reported in the red panda. The aim of this study was to describe the normal radiographic thoracic anatomy of captive red pandas as a species-specific reference for routine health examinations and clinical cases...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27575422/high-prevalence-of-concomitant-oncogene-mutations-in-prospectively-identified-patients-with-ros1-positive-metastatic-lung-cancer
#4
Marcel Wiesweg, Wilfried E E Eberhardt, Henning Reis, Saskia Ting, Nikoleta Savvidou, Charlotte Skiba, Thomas Herold, Daniel C Christoph, Johannes Meiler, Karl Worm, Stefan Kasper, Dirk Theegarten, Jörg Hense, Thomas Hager, Kaid Darwiche, Filiz Oezkan, Clemens Aigner, Stefan Welter, Hilmar Kühl, Martin Stuschke, Kurt W Schmid, Martin Schuler
PURPOSE: Chromosomal rearrangements involving ROS1 define a rare entity of lung adenocarcinomas with exquisite sensitivity to molecularly targeted therapy. We report clinical outcomes and genomic findings of patients with ROS1-positive lung cancer that were prospectively identified within a multiplex biomarker profiling program at the West German Cancer Center. PATIENTS AND METHODS: Standardized immunohistochemistry, fluorescence in situ-hybridization (FISH) and hotspot mutation analyses were performed in 1,345 advanced cancer patients, including 805 patients with metastatic lung adenocarcinoma...
August 26, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27562899/molecular-and-immunological-characterization-of-cathepsin-l-like-cysteine-protease-of-paragonimus-pseudoheterotremus
#5
Tippayarat Yoonuan, Supaporn Nuamtanong, Paron Dekumyoy, Orawan Phuphisut, Poom Adisakwattana
Cathepsin L is a cysteine protease belonging to the papain family. In parasitic trematodes, cathepsin L plays essential roles in parasite survival and host-parasite interactions. In this study, cathepsin L of the lung fluke Paragonimus pseudoheterotremus (PpsCatL) was identified and its molecular biological and immunological features characterized. A sequence analysis of PpsCatL showed that the gene encodes a 325-amino-acid protein that is most similar to P. westermani cathepsin L. The in silico three-dimensional structure suggests that PpsCatL is a pro-enzyme that becomes active when the propeptide is cleaved...
August 26, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27492228/helminth-infections-and-cardiovascular-diseases-toxocara-species-is-contributing-to-the-disease
#6
Mohammad Zibaei
Toxocariasis is the clinical term used to describe human infection with either the dog ascarid Toxocara canis or the feline ascarid Toxocara cati. As with other helminths zoonoses, the infective larvae of these Toxocara species cannot mature into adults in the human host. Instead, the worms wander through organs and tissues, mainly the liver, lungs, myocardium, kidney and central nervous system, in a vain attempt to find that, which they need to mature into adults. The migration of these immature nematode larvae causes local and systemic inflammation, resulting in the "larva migrans" syndrome...
August 3, 2016: Current Cardiology Reviews
https://www.readbyqxmd.com/read/27432058/human-pulmonary-dirofilariasis-masquerading-as-a-mass
#7
Sheba Jacob, Ashok Parameswaran, Rajan Santosham, Rajiv Santosham
Pulmonary dirofilariasis, caused by Dirofilaria immitis, rarely affects humans and is usually asymptomatic, but may present as chest pain, cough, hemoptysis, wheezing, low-grade fever, and malaise. The dead and dying worms obstruct branches of the pulmonary artery, causing infarction and a granulomatous reaction. Coin lesions are apparent on radiography, raising concern of malignancy. Complete surgical excision is the treatment of choice and an anthelmintic can be administered if residual lesions are present or the patient is from an endemic area...
September 2016: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/27313865/vectors-and-spatial-patterns-of-angiostrongylus-cantonensis-in-selected-rice-farming-villages-of-mu%C3%A3-oz-nueva-ecija-philippines
#8
Ma Angelica A Tujan, Ian Kendrich C Fontanilla, Vachel Gay V Paller
In the Philippines, rats and snails abound in agricultural areas as pests and source of food for some of the local people which poses risks of parasite transmission to humans such as Angiostrongylus cantonensis. This study was conducted to determine the extent of A. cantonensis infection among rats and snails collected from rice-farming villages of Muñoz, Nueva Ecija. A total of 209 rats, 781 freshwater snails, and 120 terrestrial snails were collected for the study. Heart and lungs of rats and snail tissues were examined and subjected to artificial digestion for parasite collection...
2016: Journal of Parasitology Research
https://www.readbyqxmd.com/read/27198783/first-report-of-metastrongylus-pudendotectus-by-the-genetic-characterization-of-mitochondria-genome-of-cox1-in-pigs-from-tibet-china
#9
Kun Li, Houqiang Luo, Hui Zhang, Yanfang Lan, Zhaoqing Han, Muhammad Shahzad, Xiaoqiang Wang, Gang Qiu, Shucheng Huang, Wenteng Jiang, Jiakui Li
Lungworms, a world wild distributed parasites cause serious respiratory diseases to the pigs. A high infection rate of Metastrongylus lungworms has been found in Tibetan pigs being slaughtered in different slaughter houses of Tibet autonomous region. The main aim of our study was to detect and confirm the lungworm parasite by the genetic characterization of mitochondrial cox1genome isolated from the lungs of Tibetan pig. The adult lungworms were collected from the lungs of slaughtered pigs and identification was done through morphological examinations...
June 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27183598/myeloid-restricted-ampk%C3%AE-1-promotes-host-immunity-and-protects-against-il-12-23p40-dependent-lung-injury-during-hookworm-infection
#10
Wildaliz Nieves, Li-Yin Hung, Taylor K Oniskey, Louis Boon, Marc Foretz, Benoit Viollet, De'Broski R Herbert
How the metabolic demand of parasitism affects immune-mediated resistance is poorly understood. Immunity against parasitic helminths requires M2 cells and IL-13, secreted by CD4(+) Th2 and group 2 innate lymphoid cells (ILC2), but whether certain metabolic enzymes control disease outcome has not been addressed. This study demonstrates that AMP-activated protein kinase (AMPK), a key driver of cellular energy, regulates type 2 immunity and restricts lung injury following hookworm infection. Mice with a selective deficiency in the AMPK catalytic α1 subunit in alveolar macrophages and conventional dendritic cells produced less IL-13 and CCL17 and had impaired expansion of ILC2 in damaged lung tissue compared with wild-type controls...
June 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27147350/electromagnetic-guided-couch-and-multileaf-collimator-tracking-on-a-truebeam-accelerator
#11
Rune Hansen, Thomas Ravkilde, Esben Schjødt Worm, Jakob Toftegaard, Cai Grau, Kristijan Macek, Per Rugaard Poulsen
PURPOSE: Couch and MLC tracking are two promising methods for real-time motion compensation during radiation therapy. So far, couch and MLC tracking experiments have mainly been performed by different research groups, and no direct comparison of couch and MLC tracking of volumetric modulated arc therapy (VMAT) plans has been published. The Varian TrueBeam 2.0 accelerator includes a prototype tracking system with selectable couch or MLC compensation. This study provides a direct comparison of the two tracking types with an otherwise identical setup...
May 2016: Medical Physics
https://www.readbyqxmd.com/read/27144645/angiostrongylus-cantonensis-infection-on-mayotte-island-indian-ocean-2007-2012
#12
Loïc Epelboin, Renaud Blondé, Abdourahim Chamouine, Alexandra Chrisment, Laure Diancourt, Nicolas Villemant, Agnès Atale, Claire Cadix, Valérie Caro, Denis Malvy, Louis Collet
INTRODUCTION: Human angiostrongyliasis (HA) is a neurological helminthic disease caused by the lung worm Angiostrongylus cantonensis. It is suspected in the combination of travel or a residence in an endemic area and eosinophilic meningitis. In Mayotte, an island in the Indian Ocean, cases are rare but regular. The main objective of our study was to describe the epidemiological and diagnosis clues of HA in Mayotte. The secondary objectives were to evaluate the contribution of Real-Time Polymerase Chain Reaction (RT- PCR) for the diagnosis of HA, delineate the characteristics of the local transmission and ascertain the presence of A...
May 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27016171/a-dosimetric-comparison-of-real-time-adaptive-and-non-adaptive-radiotherapy-a-multi-institutional-study-encompassing-robotic-gimbaled-multileaf-collimator-and-couch-tracking
#13
Emma Colvill, Jeremy Booth, Simeon Nill, Martin Fast, James Bedford, Uwe Oelfke, Mitsuhiro Nakamura, Per Poulsen, Esben Worm, Rune Hansen, Thomas Ravkilde, Jonas Scherman Rydhög, Tobias Pommer, Per Munck Af Rosenschold, Stephanie Lang, Matthias Guckenberger, Christian Groh, Christian Herrmann, Dirk Verellen, Kenneth Poels, Lei Wang, Michael Hadsell, Thilo Sothmann, Oliver Blanck, Paul Keall
PURPOSE: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion. METHODS AND MATERIALS: Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion traces and planning protocols to create a lung and a prostate plan...
April 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26972210/guidelines-on-dermatomyositis-excerpt-from-the-interdisciplinary-s2k-guidelines-on-myositis-syndromes-by-the-german-society-of-neurology
#14
Cord Sunderkötter, Alexander Nast, Margitta Worm, Reinhard Dengler, Thomas Dörner, Horst Ganter, Reinhard Hohlfeld, Arthur Melms, Nico Melzer, Kai Rösler, Jens Schmidt, Michael Sinnreich, Maggi C Walter, Julia Wanschitz, Heinz Wiendl
The present guidelines on dermatomyositis (DM) represent an excerpt from the interdisciplinary S2k guidelines on myositis syndromes of the German Society of Neurology (available at www.awmf.org). The cardinal symptom of myositis in DM is symmetrical proximal muscle weakness. Elevated creatine kinase, CRP or ESR as well as electromyography and muscle biopsy also provide important diagnostic clues. Pharyngeal, respiratory, cardiac, and neck muscles may also be affected. Given that approximately 30% of patients also develop interstitial lung disease, pulmonary function tests should be part of the diagnostic workup...
March 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/26888797/-the-worm-that-got-away-parainfectious-atypical-optic-neuritis-associated-with-schistosomiasis-infection
#15
Chinar Osman, Sally Hannigan, Adam Ditchfield, Stephen Harden, Ben Marshall, Ashwin Arnold Pinto
Although optic neuritis is commonly associated with multiple sclerosis, patients with atypical optic neuritis require further investigations to exclude other associated conditions. We report a woman presenting with cough, fatigue, atypical optic neuritis with chiasmitis. She responded partially to corticosteroids and we subsequently found she had a ground-glass lung nodule. Follow-up CT scan of thorax at 12 months showed new parenchymal lung lesions that suggested schistosomiasis. Further questioning by a respiratory physician identified, in retrospect, a previous exposure history; serological testing confirmed schistosoma infection...
June 2016: Practical Neurology
https://www.readbyqxmd.com/read/26853088/synthesis-of-a-18-f-labeled-ceritinib-analogue-for-positron-emission-tomography-of-anaplastic-lymphoma-kinase-a-receptor-tyrosine-kinase-in-lung-cancer
#16
Sandun Perera, David Piwnica-Worms, Mian M Alauddin
Anaplastic lymphoma kinase (ALK), an oncogenic receptor tyrosine kinase, has emerged as a therapeutic target in solid and hematologic tumors. Although several ALK inhibitors have gained recent approval for therapy, non-invasive indicators of target engagement or for use as predictive biomarkers in vivo are lacking. Therefore, we designed and synthesized a radiolabeled analogue of the ALK inhibitor ceritinib, [(18)F]fluoroethyl-ceritinib ([(18)F]-FEC), for use with positron emission tomography. We used two methods to synthesize [(18)F]-FEC...
March 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/26831469/comparison-of-relm%C3%AE-and-relm%C3%AE-single-and-double-gene-deficient-mice-reveals-that-relm%C3%AE-expression-dictates-inflammation-and-worm-expulsion-in-hookworm-infection
#17
Gang Chen, Spencer H Wang, Jessica C Jang, Justin I Odegaard, Meera G Nair
Resistin-like molecules (RELMs) are highly expressed following helminth infection, where they impact both the host and helminth. While RELMα (Retnla) impairs helminth expulsion by inhibiting protective Th2 immunity, RELMβ (Retnlb) can promote its expulsion. We employed Retnla(-/-) and Retnlb(-/-) mice to delineate the function of both proteins following infection with Nippostrongylus brasiliensis, a hookworm that infects the lung and intestine. Whereas wild-type (WT) and Retnlb(-/-)mice exhibited equivalent infection-induced inflammation, Retnla(-/-) mice suffered a heightened inflammatory response, including increased mortality, weight loss, and lung inflammation...
April 2016: Infection and Immunity
https://www.readbyqxmd.com/read/26827860/lung-parasites-of-the-genus-metastrongylus-molin-1861-nematoda-metastrongilidae-in-wild-boar-sus-scrofa-l-1758-in-central-italy-an-eco-epidemiological-study
#18
Giovanni Poglayen, Barbara Marchesi, Giulia Dall'Oglio, Giulia Barlozzari, Roberta Galuppi, Benedetto Morandi
The respiratory tracts of 57 wild boars (Sus scrofa L. 1758) hunted in central Italy during the 2011/2012 hunting season were examined to detect the presence of lung worms. Fifty-five out of 57 animals (96,5%) were positive. Five species of Metastrongylus were detected and their prevalence was as follows: Metastrongylus asymmetricus Noda, 1973 (91.2%), Metastrongylus confusus Jansen, 1964 and Metastrongylus salmi Gedoelst, 1923 (87.7%), Metastrongylus apri Gmelin, 1790 (80.7%), Metastrongylus pudendotectus Vostokov, 1905 (70...
February 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/26809912/new-species-of-genus-diplotriaena-railliet-and-henry-1909-filariidae-nematoda-from-passer-domesticus-linnaeus-and-p-pyrhonotus-blyth-passeridae-passeriformes-in-jamshoro-sindh-pakistan
#19
Irshad Chandio, Ali Murtaza Dharejo, Saima Naz, Muhammad Munif Khan
OBJECTIVE: The present study was conducted to examine the filarial nematodes of house sparrow [Passer domesticus (Linnaeus, 1758)] and Sindh sparrow (P. pyrrhonotus Blyth, 1844) from Jamshoro, Sindh, Pakistan. METHODS: Twenty-three house sparrows and 12 Sindh sparrows were examined for nematode parasites. A total of seven birds were found infected by 16 filarial worms belonging to the genus Diplotriaena Railliet and Henry, 1909. Birds were dissected and parasites were processed through the standard method of temporary slide mounting...
December 2015: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/26763929/the-parasitic-worm-derived-immunomodulator-es-62-and-its-drug-like-small-molecule-analogues-exhibit-therapeutic-potential-in-a-model-of-chronic-asthma
#20
J C Coltherd, D T Rodgers, R E Lawrie, L Al-Riyami, C J Suckling, W Harnett, M M Harnett
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial inflammation. As its recent dramatic increase in industrialised countries has not been mirrored in developing regions, it has been suggested that helminth infection may protect humans against developing asthma. Consistent with this, ES-62, an immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, can prevent pathology associated with chronic asthma (cellular infiltration of the lungs, particularly neutrophils and mast cells, mucus hyper-production and airway thickening) in an experimental mouse model...
2016: Scientific Reports
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