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https://www.readbyqxmd.com/read/29228018/genome-wide-association-study-identifies-a-locus-associated-with-rotator-cuff-injury
#1
Thomas R Roos, Andrew K Roos, Andrew L Avins, Marwa A Ahmed, John P Kleimeyer, Michael Fredericson, John P A Ioannidis, Jason L Dragoo, Stuart K Kim
Rotator cuff tears are common, especially in the fifth and sixth decades of life, but can also occur in the competitive athlete. Genetic differences may contribute to overall injury risk. Identifying genetic loci associated with rotator cuff injury could shed light on the etiology of this injury. We performed a genome-wide association screen using publically available data from the Research Program in Genes, Environment and Health including 8,357 cases of rotator cuff injury and 94,622 controls. We found rs71404070 to show a genome-wide significant association with rotator cuff injury with p = 2...
2017: PloS One
https://www.readbyqxmd.com/read/29222543/disclosures-in-nutrition-research-why-it-is-different
#2
John P A Ioannidis, John F Trepanowski
No abstract text is available yet for this article.
December 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29211824/corrigendum-systematic-reviews-guidance-relevant-for-studies-of-older-people
#3
Susan D Shenkin, Jennifer K Harrison, Tim Wilkinson, Richard M Dodds, John P A Ioannidis
No abstract text is available yet for this article.
December 2, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29191447/comparative-evidence-on-harms-in-pediatric-rcts-from-less-developed-versus-more-developed-countries-is-limited
#4
REVIEW
Dario Tedesco, Mufiza Farid-Kapadia, Martin Offringa, Zulfiqar A Bhutta, Yvonne Maldonado, John P A Ioannidis, Despina G Contopoulos-Ioannidis
OBJECTIVE: Evaluate comparative harm-rates from medical interventions in pediatric randomized-trials (RCTs) from more-developed (MDCs) and less-developed countries (LDCs). STUDY DESIGN: Meta-epidemiologic empirical evaluation of Cochrane Database of Systematic Reviews (June 2014) meta-analyses reporting clinically-important harm-outcomes (severe adverse events [AEs], discontinuations due to AEs, any AE and mortality) that included at least 1 pediatric-RCT from MDCs and at least 1 from LDCs...
November 27, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29174118/poor-performance-of-clinical-prediction-models-the-harm-of-commonly-applied-methods
#5
Ewout W Steyerberg, Hajime Uno, John P A Ioannidis, Ben van Calster, Chinedu Ukaegbu, Tara Dhingra, Sapna Syngal, Fay Kastrinos
OBJECTIVE: To evaluate limitations of common statistical modeling approaches in deriving clinical prediction models and explore alternative strategies. STUDY DESIGN AND SETTING: A previously published model predicted the likelihood of having a mutation at the time of diagnosis of colorectal cancer. This model was based on a cohort where 38 mutations were found among 870 participants, with validation in an independent cohort with 35 mutations. The modeling strategy included stepwise selection of predictors from a pool of 37 candidate predictors and dichotomization of continuous predictors...
November 23, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29146752/physical-activity-and-cancer-an-umbrella-review-of-the-literature-including-22-major-anatomical-sites-and-770%C3%A2-000-cancer-cases
#6
REVIEW
Leandro Fórnias Machado de Rezende, Thiago Hérick de Sá, Georgios Markozannes, Juan Pablo Rey-López, I-Min Lee, Konstantinos K Tsilidis, John P A Ioannidis, José Eluf-Neto
OBJECTIVE: To provide an overview of the breadth and validity of claimed associations between physical activity and risk of developing or dying from cancer. DESIGN: Umbrella review. DATA SOURCES: We searched Medline, Embase, Cochrane Database and Web of Science. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Systematic reviews about physical activity and cancer incidence and cancer mortality in different body sites among general population...
November 16, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29146289/off-label-treatments-were-not-consistently-better-or-worse-than-approved-drug-treatments-in-randomized-trials
#7
Aviv Ladanie, John P A Ioannidis, Randall S Stafford, Hannah Ewald, Heiner C Bucher, Lars G Hemkens
BACKGROUND: Off-label drug use is highly prevalent, but controversial and often discouraged assuming generally inferior medical effects associated with off-label use. METHODS: We searched Medline, PubMed Health and the Cochrane Library up to May 2015 for systematic reviews including meta-analyses of randomized clinical trials (RCTs) comparing off-label and approved drugs head-to-head in any population and on any medical outcome. We combined the comparative effects in meta-analyses providing summary odds ratios (sOR) for each treatment comparison and outcome, and then calculated an overall summary of the sOR across all comparisons (ssOR)...
November 13, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29055626/pulmonary-arterial-hypertension-with-abnormal-v-q-single-photon-emission-computed-tomography
#8
Kenneth Chan, Stefanos Ioannidis, John G Coghlan, Margaret Hall, Benjamin E Schreiber
OBJECTIVES: This study aimed to evaluate the incidence and clinical outcomes of abnormal ventilation/perfusion (V/Q) single-photon emission computed tomography (SPECT) without thromboembolism, especially in patients with group I pulmonary arterial hypertension (PAH). BACKGROUND: American Heart Association/American College of Cardiology and European Society of Cardiology guidelines recommend V/Q scan for screening for chronic thromboembolic pulmonary hypertension...
October 16, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29040395/human-genome-sequencing-at-the-population-scale-a-primer-on-high-throughput-dna-sequencing-and-analysis
#9
REVIEW
Rachel L Goldfeder, Dennis P Wall, Muin J Khoury, John P A Ioannidis, Euan A Ashley
Most human diseases have underlying genetic causes. To better understand the impact of genes on disease and its implications for medicine and public health, researchers have pursued methods for determining the sequences of individual genes, then all genes, and now complete human genomes. Massively parallel high-throughput sequencing technology, where DNA is sheared into smaller pieces, sequenced, and then computationally reordered and analyzed, enables fast and affordable sequencing of full human genomes. As the price of sequencing continues to decline, more and more individuals are having their genomes sequenced...
October 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28985641/a-genetic-marker-associated-with-de-quervain-s-tenosynovitis
#10
Stuart K Kim, Marwa A Ahmed, Andy L Avins, John P A Ioannidis
De Quervain's tenosynovitis is a repetitive strain injury involving synovial inflammation of the tendons of the first extensor compartment of the wrist. It is relatively common in the general population, and is the most common radial-sided tendinopathy seen in athletes. Identifying a genetic marker associated with de Quervain's tenosynovitis could provide a useful tool to help identify those individuals with an increased risk for injury. A genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health (RPGEH) including 4,129 cases and 98,374 controls...
November 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28981138/greece-crisis-smoking-and-tobacco-conflicts-in-social-media
#11
John P A Ioannidis
Greece has undergone a distressing crisis that has taken a heavy toll, devaluing lives of individuals and functions of society at large. Besides the economic meltdown, there has been an even worse crisis of values. The country currently occupies a low rank in the WHO Happiness Index (1) (99(th) in 2016 and 87(th) in 2017), not so much because of worsening ranking in healthy life expectancy (still ranked 24(th) in the world in 2017) or even wealth (still ranked 44(th) in GDP per capita), but because of mediocre ranking in social support (ranked 80(th) ) and extremely low rankings in freedom to make life choices (ranked 150(th) among 155 countries), generosity (ranked 155(th) , i...
October 5, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28957384/two-genetic-loci-associated-with-ankle-injury
#12
Stuart K Kim, John P Kleimeyer, Marwa A Ahmed, Andrew L Avins, Michael Fredericson, Jason L Dragoo, John P A Ioannidis
Ankle injuries, including sprains, strains and other joint derangements and instability, are common, especially for athletes involved in indoor court or jumping sports. Identifying genetic loci associated with these ankle injuries could shed light on their etiologies. A genome-wide association screen was performed using publicly available data from the Research Program in Genes, Environment and Health (RPGEH) including 1,694 cases of ankle injury and 97,646 controls. An indel (chr21:47156779:D) that lies close to a collagen gene, COL18A1, showed an association with ankle injury at genome-wide significance (p = 3...
2017: PloS One
https://www.readbyqxmd.com/read/28943377/interpretation-of-epidemiologic-studies-very-often-lacked-adequate-consideration-of-confounding
#13
Lars G Hemkens, Hannah Ewald, Florian Naudet, Aviv Ladanie, Jonathan G Shaw, Gautam Sajeev, John P A Ioannidis
BACKGROUND AND OBJECTIVE: Confounding bias is a most pervasive threat to validity of observational epidemiologic research. We assessed whether authors of observational epidemiologic studies consider confounding bias when interpreting the findings. STUDY DESIGN AND SETTING: We randomly selected 120 cohort or case-control studies published in 2011 and 2012 by the general medical, epidemiologic, and specialty journals with the highest impact factors. We used Web of Science to assess citation metrics through January 2017...
September 21, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28881000/how-to-survive-the-medical-misinformation-mess
#14
John P A Ioannidis, Michael E Stuart, Shannon Brownlee, Sheri A Strite
Most physicians and other healthcare professionals are unaware of the pervasiveness of poor quality clinical evidence that contributes considerably to overuse, underuse, avoidable adverse events, missed opportunities for right care and wasted healthcare resources. The Medical Misinformation Mess comprises four key problems. First, much published medical research is not reliable or is of uncertain reliability, offers no benefit to patients, or is not useful to decision makers. Second, most healthcare professionals are not aware of this problem...
September 7, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28880988/the-10-item-standardized-cosmesis-and-health-nasal-outcomes-survey-schnos-for-functional-and-cosmetic-rhinoplasty
#15
Sami P Moubayed, John P A Ioannidis, Mikhail Saltychev, Sam P Most
Importance: Rhinoplasty is a common operation in which shape and function are intimately related, whether the procedure is cosmetic, functional, or combined in nature. There is currently no properly developed and validated patient-reported outcome measure (PROM) to evaluate both functional and cosmetic components of rhinoplasty. Objective: To develop, validate, and field test the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) to evaluate both functional and cosmetic outcomes of rhinoplasty...
September 7, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28864698/development-and-validation-of-the-fracture-risk-scale-frs-that-predicts-fracture-over-a-1-year-time-period-in-institutionalised-frail-older-people-living-in-canada-an-electronic-record-linked-longitudinal-cohort-study
#16
George Ioannidis, Micaela Jantzi, Jenn Bucek, Jonathan D Adachi, Lora Giangregorio, John Hirdes, Laura Pickard, Alexandra Papaioannou
OBJECTIVES: To develop and validate our Fracture Risk Scale (FRS) over a 1-year time period, using the long-term care (LTC) Resident Assessment Instrument Minimum Data Set Version 2.0 (RAI-MDS 2.0). DESIGN: A retrospective cohort study. SETTING: LTC homes in Ontario, Canada. PARTICIPANTS: Older adults who were admitted to LTC and received a RAI-MDS 2.0 admission assessment between 2006 and 2010. RESULTS: A total of 29 848 LTC residents were enrolled in the study...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28856136/impact-of-a-genetic-risk-score-for-coronary-artery-disease-on-reducing-cardiovascular-risk-a-pilot-randomized-controlled-study
#17
Joshua W Knowles, Shirin Zarafshar, Aleksandra Pavlovic, Benjamin A Goldstein, Sandra Tsai, Jin Li, Michael V McConnell, Devin Absher, Euan A Ashley, Michaela Kiernan, John P A Ioannidis, Themistocles L Assimes
PURPOSE: We tested whether providing a genetic risk score (GRS) for coronary artery disease (CAD) would serve as a motivator to improve adherence to risk-reducing strategies. METHODS: We randomized 94 participants with at least moderate risk of CAD to receive standard-of-care with (N = 49) or without (N = 45) their GRS at a subsequent 3-month follow-up visit. Our primary outcome was change in low density lipoprotein cholesterol (LDL-C) between the 3- and 6-month follow-up visits (ΔLDL-C)...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28826375/nature-nurture-and-cancer-risks-genetic-and-nutritional-contributions-to-cancer
#18
REVIEW
Evropi Theodoratou, Maria Timofeeva, Xue Li, Xiangrui Meng, John P A Ioannidis
It is speculated that genetic variants are associated with differential responses to nutrients (known as gene-diet interactions) and that these variations may be linked to different cancer risks. In this review, we critically evaluate the evidence across 314 meta-analyses of observational studies and randomized controlled trials of dietary risk factors and the five most common cancers (breast, lung, prostate, colorectal, and stomach). We also critically evaluate the evidence across 13 meta-analyses of observational studies of gene-diet interactions for the same cancers...
August 21, 2017: Annual Review of Nutrition
https://www.readbyqxmd.com/read/28738115/inconsistent-guideline-recommendations-for-cardiovascular-prevention-and-the-debate-about-zeroing-in-on-and-zeroing-ldl-c-levels-with-pcsk9-inhibitors
#19
John P A Ioannidis
No abstract text is available yet for this article.
August 1, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28729459/enhancing-the-usability-of-systematic-reviews-by-improving-the-consideration-and-description-of-interventions
#20
Tammy C Hoffmann, Andrew D Oxman, John Pa Ioannidis, David Moher, Toby J Lasserson, David I Tovey, Ken Stein, Katy Sutcliffe, Philippe Ravaud, Douglas G Altman, Rafael Perera, Paul Glasziou
No abstract text is available yet for this article.
July 20, 2017: BMJ: British Medical Journal
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