keyword
MENU ▼
Read by QxMD icon Read
search

John ioannidis

keyword
https://www.readbyqxmd.com/read/29666377/potential-reporting-bias-in-neuroimaging-studies-of-sex-differences
#1
Sean P David, Florian Naudet, Jennifer Laude, Joaquim Radua, Paolo Fusar-Poli, Isabella Chu, Marcia L Stefanick, John P A Ioannidis
Numerous functional magnetic resonance imaging (fMRI) studies have reported sex differences. To empirically evaluate for evidence of excessive significance bias in this literature, we searched for published fMRI studies of human brain to evaluate sex differences, regardless of the topic investigated, in Medline and Scopus over 10 years. We analyzed the prevalence of conclusions in favor of sex differences and the correlation between study sample sizes and number of significant foci identified. In the absence of bias, larger studies (better powered) should identify a larger number of significant foci...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663048/are-systematic-reviews-and-meta-analyses-still-useful-research-we-are-not-sure
#2
EDITORIAL
Morten Hylander Møller, John P A Ioannidis, Michael Darmon
No abstract text is available yet for this article.
April 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29628364/antidepressants-might-work-for-people-with-major-depression-where-do-we-go-from-here
#3
Andrea Cipriani, Georgia Salanti, Toshi A Furukawa, Matthias Egger, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Lauren Z Atkinson, Anna Chaimani, Julian P T Higgins, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes
No abstract text is available yet for this article.
April 5, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29615035/real-world-evidence-how-pragmatic-are-randomized-controlled-trials-labeled-as-pragmatic
#4
Rafael Dal-Ré, Perrine Janiaud, John P A Ioannidis
INTRODUCTION: Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings. Pragmatic RCTs assess effectiveness of available medicines, while explanatory RCTs assess efficacy of investigational medicines. Explanatory and pragmatic are the extremes of a continuum. This debate article seeks to evaluate and provide recommendation on how to characterize pragmatic RCTs in light of the current landscape of RCTs...
April 3, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29596415/assessing-scientists-for-hiring-promotion-and-tenure
#5
David Moher, Florian Naudet, Ioana A Cristea, Frank Miedema, John P A Ioannidis, Steven N Goodman
Assessment of researchers is necessary for decisions of hiring, promotion, and tenure. A burgeoning number of scientific leaders believe the current system of faculty incentives and rewards is misaligned with the needs of society and disconnected from the evidence about the causes of the reproducibility crisis and suboptimal quality of the scientific publication record. To address this issue, particularly for the clinical and life sciences, we convened a 22-member expert panel workshop in Washington, DC, in January 2017...
March 29, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29574405/meta-analyses-in-environmental-and-occupational-health
#6
John P A Ioannidis
OBJECTIVES: Meta-analyses are considered generally as the highest level of evidence, but concerns have been voiced about their massive, low-quality production. This paper aimed to evaluate the landscape of meta-analyses in the field of occupational and environmental health and medicine. METHODS: Using relevant search terms, all meta-analyses were searched for, but those published in 2015 were assessed for their origin, whether they included randomised trials and individual-level data and whether they had authors from the industry or consultancy firms...
March 24, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29570246/the-obesity-paradox-a-misleading-term-that-should-be-abandoned
#7
Katherine M Flegal, John P A Ioannidis
The term "obesity paradox" is a figure of speech, not a scientific term. The term has no precise definition and has been used to describe numerous observations that have little in common other than the finding of an association of obesity with a favorable outcome. The terminology has led to misunderstandings among researchers and the public alike. It's time for authors and editors to abandon the use of this term. Simply labeling counterintuitive findings as the "obesity paradox" adds no value...
April 2018: Obesity
https://www.readbyqxmd.com/read/29566133/the-proposal-to-lower-p-value-thresholds-to-005
#8
John P A Ioannidis
No abstract text is available yet for this article.
March 22, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29534260/two-genetic-variants-associated-with-plantar-fascial-disorders
#9
Stuart K Kim, John P A Ioannidis, Marwa A Ahmed, Andrew L Avins, John P Kleimeyer, Michael Fredericson, Jason L Dragoo
Plantar fascial disorder is comprised of plantar fasciitis and plantar fibromatosis. Plantar fasciitis is the most common cause of heel pain, especially for athletes involved in running and jumping sports. Plantar fibromatosis is a rare fibrous hyperproliferation of the deep connective tissue of the foot. To identify genetic loci associated with plantar fascial disorders, a genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health including 21,624 cases of plantar fascial disorders and 80,879 controls...
March 13, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29534060/meta-research-why-research-on-research-matters
#10
John P A Ioannidis
Meta-research is the study of research itself: its methods, reporting, reproducibility, evaluation, and incentives. Given that science is the key driver of human progress, improving the efficiency of scientific investigation and yielding more credible and more useful research results can translate to major benefits. The research enterprise grows very fast. Both new opportunities for knowledge and innovation and new threats to validity and scientific integrity emerge. Old biases abound, and new ones continuously appear as novel disciplines emerge with different standards and challenges...
March 13, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29477251/comparative-efficacy-and-acceptability-of-21-antidepressant-drugs-for-the-acute-treatment-of-adults-with-major-depressive-disorder-a-systematic-review-and-network-meta-analysis
#11
Andrea Cipriani, Toshi A Furukawa, Georgia Salanti, Anna Chaimani, Lauren Z Atkinson, Yusuke Ogawa, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Julian P T Higgins, Matthias Egger, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes
BACKGROUND: Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of inadequate resources, antidepressants are used more frequently than psychological interventions. Prescription of these agents should be informed by the best available evidence. Therefore, we aimed to update and expand our previous work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder...
February 20, 2018: Lancet
https://www.readbyqxmd.com/read/29474574/evidence-based-medicine-and-big-genomic-data
#12
John P A Ioannidis, Muin J Khoury
Genomic and other related big data (Big Genomic Data, BGD for short) are ushering a new era of precision medicine. This overview discusses whether principles of evidence-based medicine (EBM) hold true for BGD and how they should be operationalized in the current era. Major EBM principles include the systematic identification, description and analysis of the validity and utility of BGD, the combination of individual clinical expertise with individual patient needs and preferences, and the focus on obtaining experimental evidence, whenever possible...
February 20, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29466592/effect-of-low-fat-vs-low-carbohydrate-diet-on-12-month-weight-loss-in-overweight-adults-and-the-association-with-genotype-pattern-or-insulin-secretion-the-dietfits-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Christopher D Gardner, John F Trepanowski, Liana C Del Gobbo, Michelle E Hauser, Joseph Rigdon, John P A Ioannidis, Manisha Desai, Abby C King
Importance: Dietary modification remains key to successful weight loss. Yet, no one dietary strategy is consistently superior to others for the general population. Previous research suggests genotype or insulin-glucose dynamics may modify the effects of diets. Objective: To determine the effect of a healthy low-fat (HLF) diet vs a healthy low-carbohydrate (HLC) diet on weight change and if genotype pattern or insulin secretion are related to the dietary effects on weight loss...
February 20, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29440066/data-sharing-and-reanalysis-of-randomized-controlled-trials-in-leading-biomedical-journals-with-a-full-data-sharing-policy-survey-of-studies-published-in-the-bmj-and-plos-medicine
#14
Florian Naudet, Charlotte Sakarovitch, Perrine Janiaud, Ioana Cristea, Daniele Fanelli, David Moher, John P A Ioannidis
OBJECTIVES: To explore the effectiveness of data sharing by randomized controlled trials (RCTs) in journals with a full data sharing policy and to describe potential difficulties encountered in the process of performing reanalyses of the primary outcomes. DESIGN: Survey of published RCTs. SETTING: PubMed/Medline. ELIGIBILITY CRITERIA: RCTs that had been submitted and published by The BMJ and PLOS Medicine subsequent to the adoption of data sharing policies by these journals...
February 13, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29432860/larger-effect-sizes-in-non-randomized-studies-are-associated-with-higher-rates-of-ema-licensing-approval
#15
Benjamin Djulbegovic, Paul Glasziou, Farina A Klocksieben, Tea Reljic, Magali VanDenBergh, Rahul Mhaskar, John P A Ioannidis, Iain Chalmers
OBJECTIVES: Evaluate how often the European Medicines Agency (EMA) has authorized drugs based on non-randomized studies and whether there is an association between treatment effects and EMA preference for further testing in RCTs. STUDY DESIGN AND SETTING: We reviewed all initial marketing authorizations in the EMA database on human medicines between 1995 and 2015 and included authorizations granted without randomized data. We extracted data on treatment effects and EMA preference for further testing in RCTs...
February 9, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29424772/systematic-identification-of-correlates-of-hiv-infection-an-x-wide-association-study
#16
Chirag J Patel, Jay Bhattacharya, John P A Ioannidis, Eran Bendavid
OBJECTIVE: Better identification of at-risk groups could benefit HIV-1 care programmes. We systematically identified HIV-1 risk factors in two nationally representative cohorts of women in the Demographic and Health Surveys. METHODS: We identified and replicated the association of 1415 social, economic, environmental, and behavioral factors with HIV-1 status. We used the 2007 and 2013-2014 surveys conducted among 5715 and 15 433 Zambian women, respectively (688 shared factors)...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29410855/modelling-science-trustworthiness-under-publish-or-perish-pressure
#17
David Robert Grimes, Chris T Bauch, John P A Ioannidis
Scientific publication is immensely important to the scientific endeavour. There is, however, concern that rewarding scientists chiefly on publication creates a perverse incentive, allowing careless and fraudulent conduct to thrive, compounded by the predisposition of top-tier journals towards novel, positive findings rather than investigations confirming null hypothesis. This potentially compounds a reproducibility crisis in several fields, and risks undermining science and public trust in scientific findings...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29386350/a-universal-standard-for-the-validation-of-blood-pressure-measuring-devices-association-for-the-advancement-of-medical-instrumentation-european-society-of-hypertension-international-organization-for-standardization-aami-esh-iso-collaboration-statement
#18
George S Stergiou, Bruce Alpert, Stephan Mieke, Roland Asmar, Neil Atkins, Siegfried Eckert, Gerhard Frick, Bruce Friedman, Thomas Graßl, Tsutomu Ichikawa, John P Ioannidis, Peter Lacy, Richard McManus, Alan Murray, Martin Myers, Paolo Palatini, Gianfranco Parati, David Quinn, Josh Sarkis, Andrew Shennan, Takashi Usuda, Jiguang Wang, Colin O Wu, Eoin O'Brien
In the past 30 years, several organizations, such as the US Association for the Advancement of Medical Instrumentation (AAMI), the British Hypertension Society, the European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring, and the International Organization for Standardization (ISO), have developed protocols for clinical validation of BP measuring devices. However, it is recognized that science, as well as patients, consumers, and manufacturers, would be best served if all BP measuring devices were assessed for accuracy according to an agreed single validation protocol that had global acceptance...
January 31, 2018: Hypertension
https://www.readbyqxmd.com/read/29384983/a-universal-standard-for-the-validation-of-blood-pressure-measuring-devices-association-for-the-advancement-of-medical-instrumentation-european-society-of-hypertension-international-organization-for-standardization-aami-esh-iso-collaboration-statement
#19
George S Stergiou, Bruce Alpert, Stephan Mieke, Roland Asmar, Neil Atkins, Siegfried Eckert, Gerhard Frick, Bruce Friedman, Thomas Graßl, Tsutomu Ichikawa, John P Ioannidis, Peter Lacy, Richard McManus, Alan Murray, Martin Myers, Paolo Palatini, Gianfranco Parati, David Quinn, Josh Sarkis, Andrew Shennan, Takashi Usuda, Jiguang Wang, Colin O Wu, Eoin O'Brien
: In the last 30 years, several organizations, such as the US Association for the Advancement of Medical Instrumentation (AAMI), the British Hypertension Society, the European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring and the International Organization for Standardization (ISO) have developed protocols for clinical validation of BP measuring devices. However, it is recognized that science, as well as patients, consumers and manufacturers would be best served if all BP measuring devices were assessed for accuracy according to an agreed single validation protocol that had global acceptance...
March 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29383638/possible-mechanisms-of-direct-cardiovascular-impact-of-glp-1-agonists-and-dpp4-inhibitors
#20
REVIEW
Vasiliki Bistola, Vaia Lambadiari, George Dimitriadis, Ioannis Ioannidis, Konstantinos Makrilakis, Nikolaos Tentolouris, Apostolos Tsapas, John Parissis
Diabetes mellitus is a leading cause of cardiovascular morbidity and mortality worldwide. Traditional antidiabetic therapies targeting hyperglycemia reduce diabetic microvascular complications but have minor effects on macrovascular complications, including cardiovascular disease. Instead, cardiovascular complications are improved by antidiabetic medications (metformin) and other therapies (statins, antihypertensive medications) ameliorating insulin resistance and other associated metabolic abnormalities. Novel classes of antidiabetic drugs have proven efficacious in improving glycemia, while at the same time exert beneficial effects on pathophysiologic mechanisms of diabetes-related cardiovascular disease...
January 31, 2018: Heart Failure Reviews
keyword
keyword
99847
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"