keyword
MENU ▼
Read by QxMD icon Read
search

John ioannidis

keyword
https://www.readbyqxmd.com/read/29440066/data-sharing-and-reanalysis-of-randomized-controlled-trials-in-leading-biomedical-journals-with-a-full-data-sharing-policy-survey-of-studies-published-in-the-bmj-and-plos-medicine
#1
Florian Naudet, Charlotte Sakarovitch, Perrine Janiaud, Ioana Cristea, Daniele Fanelli, David Moher, John P A Ioannidis
OBJECTIVES: To explore the effectiveness of data sharing by randomized controlled trials (RCTs) in journals with a full data sharing policy and to describe potential difficulties encountered in the process of performing reanalyses of the primary outcomes. DESIGN: Survey of published RCTs. SETTING: PubMed/Medline. ELIGIBILITY CRITERIA: RCTs that had been submitted and published by The BMJ and PLOS Medicine subsequent to the adoption of data sharing policies by these journals...
February 13, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29432860/larger-effect-sizes-in-non-randomized-studies-are-associated-with-higher-rates-of-ema-licensing-approval
#2
Benjamin Djulbegovic, Paul Glasziou, Farina A Klocksieben, Tea Reljic, Magali VanDenBergh, Rahul Mhaskar, John P A Ioannidis, Iain Chalmers
OBJECTIVES: Evaluate how often the European Medicines Agency (EMA) has authorized drugs based on non-randomized studies and whether there is an association between treatment effects and EMA preference for further testing in RCTs. STUDY DESIGN AND SETTING: We reviewed all initial marketing authorizations in the EMA database on human medicines between 1995 and 2015 and included authorizations granted without randomized data. We extracted data on treatment effects and EMA preference for further testing in RCTs...
February 9, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29424772/systematic-identification-of-correlates-of-hiv-infection-an-x-wide-association-study
#3
Chirag J Patel, Jay Bhattacharya, John P A Ioannidis, Eran Bendavid
OBJECTIVE: Better identification of at-risk groups could benefit HIV-1 care programmes. We systematically identified HIV-1 risk factors in two nationally representative cohorts of women in the Demographic and Health Surveys. METHODS: We identified and replicated the association of 1415 social, economic, environmental, and behavioral factors with HIV-1 status. We used the 2007 and 2013-2014 surveys conducted among 5715 and 15 433 Zambian women, respectively (688 shared factors)...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29410855/modelling-science-trustworthiness-under-publish-or-perish-pressure
#4
David Robert Grimes, Chris T Bauch, John P A Ioannidis
Scientific publication is immensely important to the scientific endeavour. There is, however, concern that rewarding scientists chiefly on publication creates a perverse incentive, allowing careless and fraudulent conduct to thrive, compounded by the predisposition of top-tier journals towards novel, positive findings rather than investigations confirming null hypothesis. This potentially compounds a reproducibility crisis in several fields, and risks undermining science and public trust in scientific findings...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29386350/a-universal-standard-for-the-validation-of-blood-pressure-measuring-devices-association-for-the-advancement-of-medical-instrumentation-european-society-of-hypertension-international-organization-for-standardization-aami-esh-iso-collaboration-statement
#5
George S Stergiou, Bruce Alpert, Stephan Mieke, Roland Asmar, Neil Atkins, Siegfried Eckert, Gerhard Frick, Bruce Friedman, Thomas Graßl, Tsutomu Ichikawa, John P Ioannidis, Peter Lacy, Richard McManus, Alan Murray, Martin Myers, Paolo Palatini, Gianfranco Parati, David Quinn, Josh Sarkis, Andrew Shennan, Takashi Usuda, Jiguang Wang, Colin O Wu, Eoin O'Brien
In the past 30 years, several organizations, such as the US Association for the Advancement of Medical Instrumentation (AAMI), the British Hypertension Society, the European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring, and the International Organization for Standardization (ISO), have developed protocols for clinical validation of BP measuring devices. However, it is recognized that science, as well as patients, consumers, and manufacturers, would be best served if all BP measuring devices were assessed for accuracy according to an agreed single validation protocol that had global acceptance...
January 31, 2018: Hypertension
https://www.readbyqxmd.com/read/29384983/a-universal-standard-for-the-validation-of-blood-pressure-measuring-devices-association-for-the-advancement-of-medical-instrumentation-european-society-of-hypertension-international-organization-for-standardization-aami-esh-iso-collaboration-statement
#6
George S Stergiou, Bruce Alpert, Stephan Mieke, Roland Asmar, Neil Atkins, Siegfried Eckert, Gerhard Frick, Bruce Friedman, Thomas Graßl, Tsutomu Ichikawa, John P Ioannidis, Peter Lacy, Richard McManus, Alan Murray, Martin Myers, Paolo Palatini, Gianfranco Parati, David Quinn, Josh Sarkis, Andrew Shennan, Takashi Usuda, Jiguang Wang, Colin O Wu, Eoin O'Brien
: In the last 30 years, several organizations, such as the US Association for the Advancement of Medical Instrumentation (AAMI), the British Hypertension Society, the European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring and the International Organization for Standardization (ISO) have developed protocols for clinical validation of BP measuring devices. However, it is recognized that science, as well as patients, consumers and manufacturers would be best served if all BP measuring devices were assessed for accuracy according to an agreed single validation protocol that had global acceptance...
March 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29383638/possible-mechanisms-of-direct-cardiovascular-impact-of-glp-1-agonists-and-dpp4-inhibitors
#7
REVIEW
Vasiliki Bistola, Vaia Lambadiari, George Dimitriadis, Ioannis Ioannidis, Konstantinos Makrilakis, Nikolaos Tentolouris, Apostolos Tsapas, John Parissis
Diabetes mellitus is a leading cause of cardiovascular morbidity and mortality worldwide. Traditional antidiabetic therapies targeting hyperglycemia reduce diabetic microvascular complications but have minor effects on macrovascular complications, including cardiovascular disease. Instead, cardiovascular complications are improved by antidiabetic medications (metformin) and other therapies (statins, antihypertensive medications) ameliorating insulin resistance and other associated metabolic abnormalities. Novel classes of antidiabetic drugs have proven efficacious in improving glycemia, while at the same time exert beneficial effects on pathophysiologic mechanisms of diabetes-related cardiovascular disease...
January 31, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29373992/beyond-genomics-understanding-exposotypes-through-metabolomics
#8
REVIEW
Nicholas J W Rattray, Nicole C Deziel, Joshua D Wallach, Sajid A Khan, Vasilis Vasiliou, John P A Ioannidis, Caroline H Johnson
BACKGROUND: Over the past 20 years, advances in genomic technology have enabled unparalleled access to the information contained within the human genome. However, the multiple genetic variants associated with various diseases typically account for only a small fraction of the disease risk. This may be due to the multifactorial nature of disease mechanisms, the strong impact of the environment, and the complexity of gene-environment interactions. Metabolomics is the quantification of small molecules produced by metabolic processes within a biological sample...
January 26, 2018: Human Genomics
https://www.readbyqxmd.com/read/29371070/immunogenicity-and-safety-of-the-multicomponent-meningococcal-b-vaccine-4cmenb-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#9
Maria Elena Flacco, Lamberto Manzoli, Annalisa Rosso, Carolina Marzuillo, Mario Bergamini, Armando Stefanati, Rosario Cultrera, Paolo Villari, Walter Ricciardi, John P A Ioannidis, Despina G Contopoulos-Ioannidis
BACKGROUND: The multicomponent meningococcal serogroup B vaccine (4CMenB) has been licensed in more than 35 countries. However, uncertainties remain about the lowest number of doses required to induce satisfactory, persistent immune responses. We did a systematic review and meta-analysis to provide quantitative estimates for the immunogenicity, persistence of immunogenicity, and safety of 4CMenB vaccine in children and adolescents. METHODS: For this systematic review and meta-analyses (proportion, head to head, and network), we searched MEDLINE, Scopus, Embase, and ClinicalTrials...
January 19, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29369337/improving-the-integrity-of-published-science-an-expanded-taxonomy-of-retractions-and-corrections
#10
Daniele Fanelli, John Pa Ioannidis, Steven Goodman
Policies and practices to correct and retract scientific articles suffer from numerous limitations that are increasingly discussed in the literature. We briefly summarize these issues and propose a new and unified taxonomy of amendment types. The proposed 13-category system both simplifies and expands existing classifications and may be used as a heuristic tool to retrospectively classify literature amendments, as a taxonomy for electronic tagging, and as a blueprint for new amendment formats that journal editors could experiment with...
January 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29362788/altmetric-scores-citations-and-publication-of-studies-posted-as-preprints
#11
Stylianos Serghiou, John P A Ioannidis
No abstract text is available yet for this article.
January 23, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29352556/what-causes-psychosis-an-umbrella-review-of-risk-and-protective-factors
#12
Joaquim Radua, Valentina Ramella-Cravaro, John P A Ioannidis, Abraham Reichenberg, Nacharin Phiphopthatsanee, Taha Amir, Hyi Yenn Thoo, Dominic Oliver, Cathy Davies, Craig Morgan, Philip McGuire, Robin M Murray, Paolo Fusar-Poli
Psychosis is a heterogeneous psychiatric condition for which a multitude of risk and protective factors have been suggested. This umbrella review aimed to classify the strength of evidence for the associations between each factor and psychotic disorders whilst controlling for several biases. The Web of Knowledge database was searched to identify systematic reviews and meta-analyses of observational studies which examined associations between socio-demographic, parental, perinatal, later factors or antecedents and psychotic disorders, and which included a comparison group of healthy controls, published from 1965 to January 31, 2017...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29325575/routinely-collected-data-for-randomized-trials-promises-barriers-and-implications
#13
REVIEW
Kimberly A Mc Cord, Rustam Al-Shahi Salman, Shaun Treweek, Heidi Gardner, Daniel Strech, William Whiteley, John P A Ioannidis, Lars G Hemkens
BACKGROUND: Routinely collected health data (RCD) are increasingly used for randomized controlled trials (RCTs). This can provide three major benefits: increasing value through better feasibility (reducing costs, time, and resources), expanding the research agenda (performing trials for research questions otherwise not amenable to trials), and offering novel design and data collection options (e.g., point-of-care trials and other designs directly embedded in routine care). However, numerous hurdles and barriers must be considered pertaining to regulatory, ethical, and data aspects, as well as the costs of setting up the RCD infrastructure...
January 11, 2018: Trials
https://www.readbyqxmd.com/read/29320509/dynamics-of-co-authorship-and-productivity-across-different-fields-of-scientific-research
#14
Austin J Parish, Kevin W Boyack, John P A Ioannidis
We aimed to assess which factors correlate with collaborative behavior and whether such behavior associates with scientific impact (citations and becoming a principal investigator). We used the R index which is defined for each author as log(Np)/log(I1), where I1 is the number of co-authors who appear in at least I1 papers written by that author and Np are his/her total papers. Higher R means lower collaborative behavior, i.e. not working much with others, or not collaborating repeatedly with the same co-authors...
2018: PloS One
https://www.readbyqxmd.com/read/29242891/diagnosis-and-treatment-of-hypertension-in-the-2017-acc-aha-guidelines-and-in-the-real-world
#15
John P A Ioannidis
No abstract text is available yet for this article.
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29228018/genome-wide-association-study-identifies-a-locus-associated-with-rotator-cuff-injury
#16
Thomas R Roos, Andrew K Roos, Andrew L Avins, Marwa A Ahmed, John P Kleimeyer, Michael Fredericson, John P A Ioannidis, Jason L Dragoo, Stuart K Kim
Rotator cuff tears are common, especially in the fifth and sixth decades of life, but can also occur in the competitive athlete. Genetic differences may contribute to overall injury risk. Identifying genetic loci associated with rotator cuff injury could shed light on the etiology of this injury. We performed a genome-wide association screen using publically available data from the Research Program in Genes, Environment and Health including 8,357 cases of rotator cuff injury and 94,622 controls. We found rs71404070 to show a genome-wide significant association with rotator cuff injury with p = 2...
2017: PloS One
https://www.readbyqxmd.com/read/29222543/disclosures-in-nutrition-research-why-it-is-different
#17
John P A Ioannidis, John F Trepanowski
No abstract text is available yet for this article.
December 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29211824/corrigendum-systematic-reviews-guidance-relevant-for-studies-of-older-people
#18
Susan D Shenkin, Jennifer K Harrison, Tim Wilkinson, Richard M Dodds, John P A Ioannidis
No abstract text is available yet for this article.
December 2, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29191447/comparative-evidence-on-harms-in-pediatric-rcts-from-less-developed-versus-more-developed-countries-is-limited
#19
REVIEW
Dario Tedesco, Mufiza Farid-Kapadia, Martin Offringa, Zulfiqar A Bhutta, Yvonne Maldonado, John P A Ioannidis, Despina G Contopoulos-Ioannidis
OBJECTIVE: Evaluate comparative harm-rates from medical interventions in pediatric randomized-trials (RCTs) from more-developed (MDCs) and less-developed countries (LDCs). STUDY DESIGN: Meta-epidemiologic empirical evaluation of Cochrane Database of Systematic Reviews (June 2014) meta-analyses reporting clinically-important harm-outcomes (severe adverse events [AEs], discontinuations due to AEs, any AE and mortality) that included at least 1 pediatric-RCT from MDCs and at least 1 from LDCs...
November 27, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29174118/poor-performance-of-clinical-prediction-models-the-harm-of-commonly-applied-methods
#20
Ewout W Steyerberg, Hajime Uno, John P A Ioannidis, Ben van Calster
OBJECTIVE: To evaluate limitations of common statistical modeling approaches in deriving clinical prediction models and explore alternative strategies. STUDY DESIGN AND SETTING: A previously published model predicted the likelihood of having a mutation in germline DNA mismatch repair genes at the time of diagnosis of colorectal cancer. This model was based on a cohort where 38 mutations were found among 870 participants, with validation in an independent cohort with 35 mutations...
November 24, 2017: Journal of Clinical Epidemiology
keyword
keyword
99847
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"