keyword
MENU ▼
Read by QxMD icon Read
search

John ioannidis

keyword
https://www.readbyqxmd.com/read/29040395/human-genome-sequencing-at-the-population-scale-a-primer-on-high-throughput-dna-sequencing-and-analysis
#1
Rachel L Goldfeder, Dennis P Wall, Muin J Khoury, John P A Ioannidis, Euan A Ashley
Most human diseases have underlying genetic causes. To better understand the impact of genes on disease and its implications for medicine and public health, researchers have pursued methods for determining the sequences of individual genes, then all genes, and now complete human genomes. Massively parallel high-throughput sequencing technology, where DNA is sheared into smaller pieces, sequenced, and then computationally reordered and analyzed, enables fast and affordable sequencing of full human genomes. As the price of sequencing continues to decline, more and more individuals are having their genomes sequenced...
October 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28985641/a-genetic-marker-associated-with-de-quervain-s-tenosynovitis
#2
Stuart K Kim, Marwa A Ahmed, Andy L Avins, John P A Ioannidis
De Quervain's tenosynovitis is a repetitive strain injury involving synovial inflammation of the tendons of the first extensor compartment of the wrist. It is relatively common in the general population, and is the most common radial-sided tendinopathy seen in athletes. Identifying a genetic marker associated with de Quervain's tenosynovitis could provide a useful tool to help identify those individuals with an increased risk for injury. A genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health (RPGEH) including 4,129 cases and 98,374 controls...
October 6, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28981138/greece-crisis-smoking-and-tobacco-conflicts-in-social-media
#3
John P A Ioannidis
Greece has undergone a distressing crisis that has taken a heavy toll, devaluing lives of individuals and functions of society at large. Besides the economic meltdown, there has been an even worse crisis of values. The country currently occupies a low rank in the WHO Happiness Index (1) (99(th) in 2016 and 87(th) in 2017), not so much because of worsening ranking in healthy life expectancy (still ranked 24(th) in the world in 2017) or even wealth (still ranked 44(th) in GDP per capita), but because of mediocre ranking in social support (ranked 80(th) ) and extremely low rankings in freedom to make life choices (ranked 150(th) among 155 countries), generosity (ranked 155(th) , i...
October 5, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28957384/two-genetic-loci-associated-with-ankle-injury
#4
Stuart K Kim, John P Kleimeyer, Marwa A Ahmed, Andrew L Avins, Michael Fredericson, Jason L Dragoo, John P A Ioannidis
Ankle injuries, including sprains, strains and other joint derangements and instability, are common, especially for athletes involved in indoor court or jumping sports. Identifying genetic loci associated with these ankle injuries could shed light on their etiologies. A genome-wide association screen was performed using publicly available data from the Research Program in Genes, Environment and Health (RPGEH) including 1,694 cases of ankle injury and 97,646 controls. An indel (chr21:47156779:D) that lies close to a collagen gene, COL18A1, showed an association with ankle injury at genome-wide significance (p = 3...
2017: PloS One
https://www.readbyqxmd.com/read/28943377/interpretation-of-epidemiological-studies-very-often-lacked-adequate-consideration-of-confounding
#5
Lars G Hemkens, Hannah Ewald, Florian Naudet, Aviv Ladanie, Jonathan G Shaw, Gautam Sajeev, John P A Ioannidis
BACKGROUND: Confounding bias is a most pervasive threat to validity of observational epidemiological research. METHODS: We assessed whether authors of observational epidemiological studies consider confounding bias when interpreting the findings. We randomly selected 120 cohort or case-control studies published in 2011 and 2012 by the general medical, epidemiological, and specialty journals with the highest impact factors. We used Web of Science to assess citation metrics through January 2017...
September 21, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28881000/how-to-survive-the-medical-misinformation-mess
#6
John P A Ioannidis, Michael E Stuart, Shannon Brownlee, Sheri A Strite
Most physicians and other healthcare professionals are unaware of the pervasiveness of poor quality clinical evidence that contributes considerably to overuse, underuse, avoidable adverse events, missed opportunities for right care and wasted healthcare resources. The Medical Misinformation Mess comprises four key problems. First, much published medical research is not reliable or is of uncertain reliability, offers no benefit to patients, or is not useful to decision makers. Second, most healthcare professionals are not aware of this problem...
September 7, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28880988/the-10-item-standardized-cosmesis-and-health-nasal-outcomes-survey-schnos-for-functional-and-cosmetic-rhinoplasty
#7
Sami P Moubayed, John P A Ioannidis, Mikhail Saltychev, Sam P Most
Importance: Rhinoplasty is a common operation in which shape and function are intimately related, whether the procedure is cosmetic, functional, or combined in nature. There is currently no properly developed and validated patient-reported outcome measure (PROM) to evaluate both functional and cosmetic components of rhinoplasty. Objective: To develop, validate, and field test the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) to evaluate both functional and cosmetic outcomes of rhinoplasty...
September 7, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28864698/development-and-validation-of-the-fracture-risk-scale-frs-that-predicts-fracture-over-a-1-year-time-period-in-institutionalised-frail-older-people-living-in-canada-an-electronic-record-linked-longitudinal-cohort-study
#8
George Ioannidis, Micaela Jantzi, Jenn Bucek, Jonathan D Adachi, Lora Giangregorio, John Hirdes, Laura Pickard, Alexandra Papaioannou
OBJECTIVES: To develop and validate our Fracture Risk Scale (FRS) over a 1-year time period, using the long-term care (LTC) Resident Assessment Instrument Minimum Data Set Version 2.0 (RAI-MDS 2.0). DESIGN: A retrospective cohort study. SETTING: LTC homes in Ontario, Canada. PARTICIPANTS: Older adults who were admitted to LTC and received a RAI-MDS 2.0 admission assessment between 2006 and 2010. RESULTS: A total of 29 848 LTC residents were enrolled in the study...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28856136/impact-of-a-genetic-risk-score-for-coronary-artery-disease-on-reducing-cardiovascular-risk-a-pilot-randomized-controlled-study
#9
Joshua W Knowles, Shirin Zarafshar, Aleksandra Pavlovic, Benjamin A Goldstein, Sandra Tsai, Jin Li, Michael V McConnell, Devin Absher, Euan A Ashley, Michaela Kiernan, John P A Ioannidis, Themistocles L Assimes
PURPOSE: We tested whether providing a genetic risk score (GRS) for coronary artery disease (CAD) would serve as a motivator to improve adherence to risk-reducing strategies. METHODS: We randomized 94 participants with at least moderate risk of CAD to receive standard-of-care with (N = 49) or without (N = 45) their GRS at a subsequent 3-month follow-up visit. Our primary outcome was change in low density lipoprotein cholesterol (LDL-C) between the 3- and 6-month follow-up visits (ΔLDL-C)...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28826375/nature-nurture-and-cancer-risks-genetic-and-nutritional-contributions-to-cancer
#10
REVIEW
Evropi Theodoratou, Maria Timofeeva, Xue Li, Xiangrui Meng, John P A Ioannidis
It is speculated that genetic variants are associated with differential responses to nutrients (known as gene-diet interactions) and that these variations may be linked to different cancer risks. In this review, we critically evaluate the evidence across 314 meta-analyses of observational studies and randomized controlled trials of dietary risk factors and the five most common cancers (breast, lung, prostate, colorectal, and stomach). We also critically evaluate the evidence across 13 meta-analyses of observational studies of gene-diet interactions for the same cancers...
August 21, 2017: Annual Review of Nutrition
https://www.readbyqxmd.com/read/28738115/inconsistent-guideline-recommendations-for-cardiovascular-prevention-and-the-debate-about-zeroing-in-on-and-zeroing-ldl-c-levels-with-pcsk9-inhibitors
#11
John P A Ioannidis
No abstract text is available yet for this article.
August 1, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28729459/enhancing-the-usability-of-systematic-reviews-by-improving-the-consideration-and-description-of-interventions
#12
Tammy C Hoffmann, Andrew D Oxman, John Pa Ioannidis, David Moher, Toby J Lasserson, David I Tovey, Ken Stein, Katy Sutcliffe, Philippe Ravaud, Douglas G Altman, Rafael Perera, Paul Glasziou
No abstract text is available yet for this article.
July 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28710141/perspective-improving-nutritional-guidelines-for-sustainable-health-policies-current-status-and-perspectives
#13
Paolo Magni, Dennis M Bier, Sergio Pecorelli, Carlo Agostoni, Arne Astrup, Furio Brighenti, Robert Cook, Emanuela Folco, Luigi Fontana, Robert A Gibson, Ranieri Guerra, Gordon H Guyatt, John Pa Ioannidis, Ann S Jackson, David M Klurfeld, Maria Makrides, Basil Mathioudakis, Alessandro Monaco, Chirag J Patel, Giorgio Racagni, Holger J Schünemann, Raanan Shamir, Niv Zmora, Andrea Peracino
A large body of evidence supports the notion that incorrect or insufficient nutrition contributes to disease development. A pivotal goal is thus to understand what exactly is appropriate and what is inappropriate in food ingestion and the consequent nutritional status and health. The effective application of these concepts requires the translation of scientific information into practical approaches that have a tangible and measurable impact at both individual and population levels. The agenda for the future is expected to support available methodology in nutrition research to personalize guideline recommendations, properly grading the quality of the available evidence, promoting adherence to the well-established evidence hierarchy in nutrition, and enhancing strategies for appropriate vetting and transparent reporting that will solidify the recommendations for health promotion...
July 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28692782/a-comparison-of-bivariate-multivariate-random-effects-and-poisson-correlated-gamma-frailty-models-to-meta-analyze-individual-patient-data-of-ordinal-scale-diagnostic-tests
#14
Gabrielle Simoneau, Brooke Levis, Pim Cuijpers, John P A Ioannidis, Scott B Patten, Ian Shrier, Charles H Bombardier, Flavia de Lima Osório, Jesse R Fann, Dwenda Gjerdingen, Femke Lamers, Manote Lotrakul, Bernd Löwe, Juwita Shaaban, Lesley Stafford, Henk C P M van Weert, Mary A Whooley, Karin A Wittkampf, Albert S Yeung, Brett D Thombs, Andrea Benedetti
Individual patient data (IPD) meta-analyses are increasingly common in the literature. In the context of estimating the diagnostic accuracy of ordinal or semi-continuous scale tests, sensitivity and specificity are often reported for a given threshold or a small set of thresholds, and a meta-analysis is conducted via a bivariate approach to account for their correlation. When IPD are available, sensitivity and specificity can be pooled for every possible threshold. Our objective was to compare the bivariate approach, which can be applied separately at every threshold, to two multivariate methods: the ordinal multivariate random-effects model and the Poisson correlated gamma-frailty model...
July 10, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28655142/systematic-reviews-guidance-relevant-for-studies-of-older-people
#15
Susan D Shenkin, Jennifer K Harrison, Tim Wilkinson, Richard M Dodds, John P A Ioannidis
Systematic reviews and meta-analyses are increasingly common. This article aims to provide guidance for people conducting systematic reviews relevant to the healthcare of older people. An awareness of these issues will also help people reading systematic reviews to determine whether the results will influence their clinical practice. It is essential that systematic reviews are performed by a team which includes the required technical and clinical expertise. Those performing reviews for the first time should ensure they have appropriate training and support...
September 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28645203/neurosurgical-randomized-controlled-trials-distance-travelled
#16
Tej D Azad, Anand Veeravagu, Vaishali Mittal, Rogelio Esparza, Eli Johnson, John P A Ioannidis, Gerald A Grant
BACKGROUND: The evidence base for many neurosurgical procedures has been limited. We performed a comprehensive and systematic analysis of study design, quality of reporting, and trial results of neurosurgical randomized controlled trials (RCTs). OBJECTIVE: To systematically assess the design and quality characteristics of neurosurgical RCTs. METHODS: From January 1961 to June 2016, RCTs with >5 patients assessing any 1 neurosurgical procedure against another procedure, nonsurgical treatment, or no treatment were retrieved from MEDLINE, Scopus, and Cochrane Library...
June 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28632861/nonreproducibility-of-preclinical-research-reply
#17
LETTER
John P A Ioannidis
No abstract text is available yet for this article.
June 20, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28611196/atf3-repression-of-bcl-xl-determines-apoptotic-sensitivity-to-hdac-inhibitors-across-tumor-types
#18
Anderly C Chüeh, Janson W T Tse, Michael Dickinson, Paul Ioannidis, Laura Jenkins, Lars Togel, BeeShin Tan, Ian Luk, Mercedes Davalos-Salas, Rebecca Nightingale, Matthew R Thompson, Bryan R G Williams, Guillaume Lessene, Erinna F Lee, Walter D Fairlie, Amardeep S Dhillon, John M Mariadason
Purpose: Histone deacetylase inhibitors (HDACi) are epigenome-targeting small molecules approved for the treatment of cutaneous T-cell lymphoma and multiple myeloma. They have also demonstrated clinical activity in acute myelogenous leukemia, non-small cell lung cancer, and estrogen receptor-positive breast cancer, and trials are underway assessing their activity in combination regimens including immunotherapy. However, there is currently no clear strategy to reliably predict HDACi sensitivity. In colon cancer cells, apoptotic sensitivity to HDACi is associated with transcriptional induction of multiple immediate-early (IE) genes...
September 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28589600/timing-and-characteristics-of-cumulative-evidence-available-on-novel-therapeutic-agents-receiving-food-and-drug-administration-accelerated-approval
#19
Huseyin Naci, Olivier J Wouters, Radhika Gupta, John P A Ioannidis
Policy Points: Randomized trials-the gold standard of evaluating effectiveness-constitute a small minority of existing evidence on agents given accelerated approval. One-third of randomized trials are in therapeutic areas outside of FDA approval and less than half evaluate the therapeutic benefits of these agents but use them instead as common backbone treatments. Agents receiving accelerated approval are often tested concurrently in several therapeutic areas. For most agents, no substantial time lag is apparent between the average start dates of randomized trials evaluating their effectiveness and those using them as part of background therapies...
June 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/28532614/evidence-based-medicine-was-bound-to-fail-a-report-to-alvan-feinstein
#20
Giovanni A Fava
John Ioannidis has provided a lucid account, in the form of a report to David Sackett, of how evidence-based medicine (EBM) was hijacked to serve vested interests: major randomized controlled trials are largely done by and for the benefit of the industry; meta-analyses and guidelines are flooded with conflicts of interest; national and federal research funds are unable to address basic clinical questions. Nonetheless, EBM would remain a worthwhile goal. In this paper, in the form of a report to Alvan Feinstein, it is argued that current developments were largely predictable...
April 2017: Journal of Clinical Epidemiology
keyword
keyword
99847
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"