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adrenal supression with glucocorticoids

Hatice Ozisik, Banu Sarer Yurekli, Ilgin Yildirim Simsir, Ilker Altun, Utku Soyaltin, Ezgi Guler, Huseyin Onay, Banu Sarsik, Fusun Saygili
Congenital adrenal hyperplasia is one of the most common autosomal recessive genetic disorders. Testicular adrenal tumors are significant complications of congenital adrenal hyperplasia. We would like to present two patients of testicular adrenal rest tumors. Patient 1 24 year-old male, he was diagnosed with congenital adrenal hyperplasia at the age of 8 due to precocious puberty. He received hydro-cortisone treatment until the age of 18. Testicular mass had been detected and right radical orchiectomy had been applied 6 months ago and reported as testicular adrenal rest tumor...
September 2017: European Journal of Medical Genetics
A K Short, K A Fennell, V M Perreau, A Fox, M K O'Bryan, J H Kim, T W Bredy, T Y Pang, A J Hannan
Recent studies have suggested that physiological and behavioral traits may be transgenerationally inherited through the paternal lineage, possibly via non-genomic signals derived from the sperm. To investigate how paternal stress might influence offspring behavioral phenotypes, a model of hypothalamic-pituitary-adrenal (HPA) axis dysregulation was used. Male breeders were administered water supplemented with corticosterone (CORT) for 4 weeks before mating with untreated female mice. Female, but not male, F1 offspring of CORT-treated fathers displayed altered fear extinction at 2 weeks of age...
June 14, 2016: Translational Psychiatry
Zlatan Fatusić
Cortikosteroids, a hormons of adrenal glands have a influence to almost all organic sistems because of their antiinflamatory and immunosupressive effects. They are used in perinatology to accelerate lungs maturation in expected premature labour. The most frequent used corticosteroids are bethamethason and dexamethason, with useful effects: acceleration of growth of fetal lungs by ripening pneumocites type II and supression of creating secundary septs; by protection of brain from intraventricular haemorrhage and periventricular leucomalation; decreasing rate of rethinopathy and enterocolitis and ductus artheriosus persistens...
2004: Medicinski Arhiv
G G Nussdorfer
Adrenomedullin (ADM) and proadrenomedullin N-terminal 20 peptide (PAMP) are widely distributed in various body tissues and organs, including the hypothalamo-pituitary-adrenal (HPA) axis. ADM and PAMP inhibit in vitro release of ACTH from pituitary corticotropes, and findings suggest that this effect may become relevant when an exceedingly high ACTH secretion must be counteracted. ADM directly supresses angiotensin-II- and K+-stimulated aldosterone secretion from ZG cells, acting through calcitonin gene-related peptide (CGRP) type 1 ADM(22-52)-sensitive receptors, the activation of which is likely to impair Ca2+ influx...
2001: International Review of Cytology
J M Miralles García, D Outerino, A García-Fernández, S de Castro del Pozo, M C Valentín
Thirteen cases of bronchopulmonary carcinomas without symptoms of hypercorticoidism, hypopotassemic alkalosis, or intolerance to an overdose of glucose are described. Repeated circadian rhythm and the suppression test with small doses of dexamethasone were practiced on each one. In 7 cases the secretion of cortisol was supressed normally with oral administration of dexametahsone. In the other 6 cases the circadian rhythm was lost and it was imposible to reduce the plasma level of cortisol with dexamethasone...
January 10, 1979: Medicina Clínica
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