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Miquel Avella-Oliver, Javier Carrascosa, Rosa Puchades, Ángel Maquieira
A novel label-free biosensing approach based on bioreceptor networks patterned as diffractive gratings (biogratings) has been developed. Nanogrooved structures were used as optically active scaffolds for producing arrays of functional BSA biogratings on low energy surfaces by a water-assisted variant of microcontact printing. An analytical scanner, comprising a LightScribe compact disk drive, was developed to measure the diffraction patterns of these biogratings, thus allowing biointeractions to be quantitatively sensed in a multiplex and label-free fashion by means of diffraction efficiency changes...
September 5, 2017: Analytical Chemistry
Karen Y Oróstica, Ricardo A Verdugo
UNLABELLED: : Visualizing genomic data in chromosomal context can help detecting errors in data processing and may suggest new hypotheses to be tested. Here, we report a new tool for displaying large and diverse genomic data along chromosomes. The software is implemented in R so that visualization can be easily integrated with its numerous packages for processing genomic data. It supports simultaneous visualization of multiple tracks of data. Large genomic regions such as QTLs or synteny tracts may be shown along histograms of number of genes, genetic variants, or any other type of genomic element...
August 1, 2016: Bioinformatics
Jae-Won Huh, Dae-Soo Kim, Hong-Seok Ha, Kung Ahn, Kyu-Tae Chang, Byung-Wook Cho, Heui-Soo Kim
Porcine endogenous retroviruses (PERVs) gamma1 in the pig genome have the potential to act as harmful factors in xenotransplantation (pig-to-human). Long terminal repeats (LTRs) are known to be strong promoter elements that could control the transcription activity of PERV elements and the adjacent functional genes. To investigate the transcribed PERV gamma1 LTR elements in pig tissues, bioin-formatic and experimental approaches were conducted. Using RT-PCR amplification and sequencing approaches, 69 different transcribed LTR elements were identified...
January 31, 2009: Molecules and Cells
Rosalba Alonso Campero, Roberto Bernardo Escudero, Doris Del Cisne Valle Alvarez, Mario González de la Parra, Salvador Namur Montalvo, Victoria Burke Fraga, Rodolfo Silva Hernandez, Alberto De Lago Acosta
BACKGROUND: Trimethoprim/sulfamethoxazole (TMP/SMX) is a combination of 2 antimicrobial agents that act synergistically, sequentially blocking 2 chemical reactions essential to bacterial survival. TMP/SMX is effective against organisms that are resistant to its separate components. OBJECTIVE: The objective of this study was to compare the bioavailability of 2 commercial preparations of T:MP/SMX 40/200 mg per 5-ml, oral suspension, used in Mexico for the treatment of bacterial infection...
February 2007: Clinical Therapeutics
E Schrader, W Schwankl, C Sieder, V Christoffel
The relative oral bioavailability of beta-escine (CAS 11072-93-8) from a sugar-coated tablet formulation was compared to a reference preparation available in capsule form in 18 healthy, male volunteers over a 48 h period. The study design was randomized, single-blind and cross-over. Both the test and the reference preparation contained 50 mg standardized horse chestnut seed extract; beta-escine was taken as the reference substance. By means of a newly developed, validated radioimmunosorbent assay (RIA), beta-escine in plasma was determined (blind samples) after oral intake of a single dose of each drug formulation...
September 1995: Die Pharmazie
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