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https://www.readbyqxmd.com/read/29226152/the-phytoestrogen-genistein-produces-similar-effects-as-17%C3%AE-estradiol-on-anxiety-like-behavior-in-rats-at-12-weeks-after-ovariectomy
#1
Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo, Abraham Puga-Olguín, Eduardo Rivadeneyra-Domínguez, Blandina Bernal-Morales, Emma Virginia Herrera-Huerta, Andrea Santos-Torres
The phytoestrogen genistein produces anxiolytic-like effects in ovariectomized rats, which highlights its potential therapeutic effect in ameliorating anxiety in surgical menopausal women. However, no studies have directly compared the effects of identical doses of genistein and 17β-estradiol, the main estrogen used in hormone replacement therapy in menopausal women. The present study evaluated the anxiolytic-like effects of identical doses of genistein and 17β-estradiol (0.045, 0.09, and 0.18 mg/kg/7 days, s...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225059/effect-of-music-on-outpatient-urological-procedures-a-systematic-review-and-meta-analysis-from-european-section-of-uro-technology-esut
#2
Rena Kyriakides, Patrick Jones, Robert Geraghty, Andreas Skolarikos, Evangellos Liatsikos, Olivier Traxer, Amelia Pietropaolo, Bhaskar K Somani
PURPOSE: Music is a practical, cheap and harmless analgesic and anxiolytic. An increasing number of original studies have been performed investigating its potential application in urology. Our aim was to identify the effect of music on outpatient based urological procedures. METHOD: A systematic review was performed on the effect of using music during all reported outpatient urology procedures including transrectal ultrasound guided prostate biopsy (TRUS), shock-wave lithotripsy (SWL), urodynamic studies (UDS), percutaneous nephrostomy (PCN) tube placement and cystoscopy...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29223391/effects-of-a-hydroethanolic-extract-of-boophone-disticha-bulb-on-anxiety-related-behaviour-in-naive-balb-c-mice
#3
William Pote, Shamiso Musarira, Donald Chuma, Louis L Gadaga, Ellen Mwandiringana, Dexter Tagwireyi
ETHNOPHARMACOLOGICAL RELEVANCE: Boophone disticha is one of the most important medicinal bulbs of Southern Africa. Previous in vitro studies have shown that it's crude ethanolic extracts and some alkaloidal phytoconstituents possesses high affinity for the serotonin transporter protein (SERT) and serotonin receptor 1a (5HT1a) which are both implicated in the pathogenesis and treatment of anxiety disorders. However, there are no in vivo studies that validates the anxiolytic actions of the plant...
December 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29217174/n-propyl-2-2-diphenyl-2-hydroxyacetamide-a-novel-%C3%AE-hydroxyamide-with-anticonvulsant-anxiolytic-and-antidepressant-like-effects-that-inhibits-voltage-gated-sodium-channels
#4
Valentina Pastore, Cristina Wasowski, Pedro Martin, Andrea Enrique, Josefina Higgs, Luis E Bruno-Blanch, Veronica Milesi, Mariel Marder
In patients with epilepsy, anxiety and depression are the most frequent psychiatric comorbidities but they often remain unrecognized and untreated. We report herein the antidepressant-like activity in two animal models, tail suspension and forced swimming tests, of six anticonvulsants α-hydroxyamides. From these, N-propyl-2,2-diphenyl-2-hydroxyacetamide (compound 5) emerged not only as the most active as anticonvulsant (ED50= 2.5mg/kg, MES test), but it showed the most remarkable antidepressant-like effect in the tail suspension and forced swimming tests (0...
December 4, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29217165/anxiolytic-and-antidepressant-like-activities-of-a-methanolic-extract-of-morinda-citrifolia-linn-noni-fruit-in-mice-involvement-of-benzodiazepine-gabaaergic-serotonergic-and-adrenergic-systems
#5
Megala Narasingam, Kamini Vijeepallam, Zahurin Mohamed, Vijayapandi Pandy
This study presents anxiolytic- and antidepressant-like effects of a methanolic extract of Morinda citrifolia Linn. (noni) fruit (MMC) in well-established mouse models of anxiety and depression. The administration of MMC (1 g/kg, p.o.) and diazepam (1 mg/kg, i.p.) significantly attenuated anxiety-like behaviour in mice by increasing the percentage of time spent and number of entries in the open arms in the elevated plus maze (EPM), and significantly enhanced the exploration in the light box in the light/dark test (LDT)...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29216745/differential-experimental-effects-of-a-short-bout-of-walking-meditation-or-combination-of-walking-and-meditation-on-state-anxiety-among-young-adults
#6
Meghan K Edwards, Simon Rosenbaum, Paul D Loprinzi
INTRODUCTION: Single bouts of aerobic exercise and meditation have been shown to improve anxiety states. Yet to be evaluated in the literature, we sought to examine the effects of a single, short bout of aerobic exercise or meditation, as well as exercise and meditation combined on state anxiety among young adults. DESIGN: Randomized controlled trial. SETTING: University. SUBJECTS: Participants (N = 110, mean age = 21...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29216521/the-use-of-palliative-medications-before-death-from-prostate-cancer-swedish-population-based-study-with-a-comparative-overview-of-european-data
#7
Magdalena Lycken, Linda Drevin, Hans Garmo, Pär Stattin, Jan Adolfsson, Ingela Franck Lissbrant, Lars Holmberg, Anna Bill-Axelson
BACKGROUND: Symptoms of terminal cancer have previously been reported as undertreated. The aim of this study was to assess the use of palliative medications before death from prostate cancer. METHODS: This Swedish register study included men who died from 2009 to 2012 with prostate cancer as the underlying cause of death. We assessed the proportion who collected a prescription of androgen deprivation therapy, non-steroidal anti-inflammatory drugs, paracetamol, opioids, glucocorticoids, antidepressants, anxiolytics and sedative-hypnotics and the differences in treatment related to age, time since diagnosis, educational level, close relatives and comorbidities...
December 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29212346/palliative-care-providers-practices-surrounding-psychological-distress-screening-and-treatment-a-national-survey
#8
Elissa Kozlov, Claude Eghan, Sheila Moran, Keela Herr, M Carrington Reid
OBJECTIVE: To investigate how inpatient palliative care teams nationwide currently screen for and treat psychological distress. METHODS: A web-based survey was sent to inpatient palliative care providers of all disciplines nationwide asking about their practice patterns regarding psychological assessment and treatment. Descriptive statistics were used to characterize the sample and responses, and analysis of variance was conducted to determine whether certain disciplines were more likely to utilize specific treatment modalities...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29211139/use-of-psychotropic-medications-in-adults-and-elderly-living-in-campinas-s%C3%A3-o-paulo-brazil-cross-sectional-population-based-study
#9
Maria Aparecida Medeiros Barros do Prado, Priscila Maria S Bergamo Francisco, Marilisa Berti de Azevedo Barros
OBJECTIVE: to estimate the prevalence of use of psychotropic medicines and associated factors in adults and elderly, and to identify the main classes used. METHODS: cross-sectional population-based study, conducted in Campinas-SP, Brazil (January/2008-April/2009); chi-square Rao-Scott test and Poisson multiple regression were applied. RESULTS: the study included 2,472 individuals and the prevalence of use of at least one psychotropic medication in the three previous days was 6...
October 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29210995/support-for-natural-small-molecule-phenols-as-anxiolytics
#10
Xiaohong Wang, Yahong Chen, Qiang Wang, Lu Sun, Guiyun Li, Chanxi Zhang, Jianmei Huang, Lei Chen, Haifeng Zhai
Natural small-molecule phenols (NSMPs) share some bioactivities. The anxiolytic activity of NSMPs is attracting attention in the scientific community. This paper provides data supporting the hypothesis that NSMPs are generally anxiolytic. The anxiolytic activities of seven simple phenols, including phloroglucinol, eugenol, protocatechuic aldehyde, vanillin, thymol, ferulic acid, and caffeic acid, were assayed with the elevated plus maze (EPM) test in mice. The oral doses were 5, 10 and 20 mg/kg, except for phloroglucinol for which the doses were 2...
December 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29210709/alphaxalone-binds-in-inner-transmembrane-%C3%AE-%C3%AE-interfaces-of-%C3%AE-1%C3%AE-3%C3%AE-2-%C3%AE-aminobutyric-acid-type-a-receptors
#11
Alexis M Ziemba, Andrea Szabo, David W Pierce, Marian Haburcak, Alex T Stern, Anahita Nourmahnad, Elizabeth S Halpin, Stuart A Forman
BACKGROUND: Neurosteroids like alphaxalone are potent anxiolytics, anticonvulsants, amnestics, and sedative-hypnotics, with effects linked to enhancement of γ-aminobutyric acid type A (GABAA) receptor gating in the central nervous system. Data locating neurosteroid binding sites on synaptic αβγ GABAA receptors are sparse and inconsistent. Some evidence points to outer transmembrane β-α interfacial pockets, near sites that bind the anesthetics etomidate and propofol. Other evidence suggests that steroids bind more intracellularly in β-α interfaces...
November 28, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29210667/nerolidol-and-its-pharmacological-application-in-treating-neurodegenerative-diseases-a-review
#12
Rusbene Bruno Fonseca De Carvalho, Antonia Amanda Cardoso De Almeida, Neylon Barbosa Campelo, Daniel Ramon Oliveira Dantas Lellis, Livio Cesar Cunha Nunes
BACKGROUND: Research on natural bioactive compounds has increased exponentially over the last decades. The discovery of new phytochemicals that possess pharmaceutical properties is useful in the development of therapeutic alternatives. The nerolidol (3,7,11-trimetil-1,6,10-dodecatrien-3-ol or 3,7,11-trimetildodeca-1,6,10-trien-3-ol) has been extensively studied for its therapeutic potential because of its pharmacological activities in the treatment of neurodegenerative diseases. METHODS: All articles and patents regarding to nerolidol and its pharmacological properties were revised, focusing mainly on the important properties in the treatment of neurodegenerative diseases...
December 6, 2017: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/29205599/postnatal-separation-prevents-the-development-of-prenatal-stress-induced-anxiety-in-association-with-changes-in-estrogen-receptor-and-oxytocin-immunoreactivity-in-female-mandarin-vole-microtus-mandarinus-offspring
#13
Fengqin He, Zijian Wang, Guanlin Guo
Estrogen has both anxiogenic and anxiolytic effects because of variation in opposing action on alpha (ERα) and beta (ERβ) estrogen receptors in the medial preoptic area (mPOA), bed nucleus of the stria terminalis (BNST) and medial amygdala (MeA). Oxytocin (OT) reverses some of the anxiogenic effects of estrogen in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON). Because anxiety disorders are twice as common in women as in men, and estrogen and OT are more important in females, we examined interactions between prenatal restraint stress (GS) and postnatal early short-term maternal separation (MS) and female mandarin vole behavior, estrogen receptors and OT...
December 4, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29203736/the-exchange-of-monoamines-during-the-experimental-neurosis-on-the-background-of-using-of-amide-2-hydroxy-n-naphthalen-1-yl-2-2-oxo-2-dihydroindol-3-ylidene
#14
Ruslan V Lutsenko, Elena V Vlasova, Elina G Kolot, Victoria M Gladka, Antonina G Sidorenko
INTRODUCTION: Incessant increase in the frequency and distribution of anxiety disorders stipulates searching, research and study of the mechanism of action of new substances for their correction, including the group of 2-oxoindolin-3-glyoxylic acid derivatives. THE AIM: To research the effect of N-(1-naphthyl) amide-2-oxoindolin-3-glyoxylic acid on monoaminergic system of subjected to experimental neurosis of rats. MATERIALS AND METHODS: The experiments were performed on male Wistar rats, who have weight 180-220g and were researching the effect of 2-hydro-N-naphthalen-1-yl-2-(2-oxy-1,2-dihydroindol-3-ylidene)-acetamide (compound 18) at a dose (12 mg/kg), by intragastric drug injection of subjected to experimental neurosis rats, during 30 days (1 time in three days), for monoamines content (epinephrine, norepinephrine, dopamine and serotonin) in the blood, their decay products (homovanillic acid, vanillylmandelic acid and 5-oxyindolacetic acid) in the urine and the ratio of end products of the reaction to their predecessors...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29201489/factors-affecting-health-related-quality-of-life-in-hospitalized-patients-with-heart-failure
#15
Georgia Audi, Aggeliki Korologou, Ioannis Koutelekos, Georgios Vasilopoulos, Kostas Karakostas, Kleanthi Makrygianaki, Maria Polikandrioti
This study identified factors affecting health related quality of life (HRQOL) in 300 hospitalized patients with heart failure (HF). Data were collected by the completion of a questionnaire which included patients' characteristics and the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Analysis of data showed that the median of the total score of MLHFQ was 46 and the median of the physical and mental state was 22 and 6, respectively. Also, participants who were householders or had "other" professions had lower score of 17 points and therefore better quality of life compared to patients who were civil/private employees (p < 0...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29196383/opioid-analgesic-use-in-patients-with-ankylosing-spondylitis-an-analysis-of-the-prospective-study-of-outcomes-in-an-ankylosing-spondylitis-cohort
#16
Jonathan D Dau, MinJae Lee, Michael M Ward, Lianne S Gensler, Matthew A Brown, Thomas J Learch, Laura A Diekman, Amirali Tahanan, Mohammad H Rahbar, Michael H Weisman, John D Reveille
OBJECTIVE: Opioid analgesics may be prescribed to ankylosing spondylitis (AS) patients with pain that is unresponsive to antirheumatic treatment. Our study assessed factors associated with opioid usage in AS. METHODS: A prospective cohort of 706 patients with AS meeting modified New York criteria followed at least 2 years underwent comprehensive clinical evaluation of disease activity and functional impairment. These were assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI)...
December 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29195839/the-ventromedial-hypothalamic-nucleus-plays-an-important-role-in-anxiolytic-like-effect-of-neuropeptide-s
#17
Jin Hong Jiang, Ya Li Peng, Pei Jiang Zhang, Hong Xiang Xue, Zhen He, Xue Ya Liang, M Chang
Neuropeptide S (NPS), the endogenous neuropeptide ligand of NPSR, has been reported to regulate anxiety-related behavior involved in multiple brain regions, including amygdale, locus coeruleus and Barrington's nucleus. However, little research has been conducted on the anxiolytic-like behaviors of NPS on the hypothalamus, which was an important area in defensive behavior. Here, we investigated a role of hypothalamus in anxiolytic-like behaviors of NPS. We found that NPSR protein of mouse distributed mainly in the ventromedial hypothalamus (VMH)...
November 7, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29194280/conization-and-healthcare-use-a-population-based-register-study
#18
Maria E Frederiksen, Miguel Vázquez-Prada Baillet, Pernille T Jensen, Carsten Rygaard, Jesper Hallas, Elsebeth Lynge
The aim of this study was to assess whether negative psychological consequences of conization reported in questionnaire studies translated into increased use of the healthcare services that could relieve such symptoms. This was a population-based register study comparing women undergoing conization with a control group of women with normal cytology results. Data were derived from Danish registers. Using the difference-in-differences method, we measured contacts with general practitioners (GPs), hospitals, psychiatrist/psychologists, and use of anxiolytic and antidepressant prescription drugs over 5 years 'before' and 'after' the conization in the study group, and in comparable periods in the control group...
November 29, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29191711/analyzing-test-batteries-in-animal-models-of-psychopathology-with-multivariate-analysis-of-variance-manova-one-possible-approach-to-increase-external-validity
#19
Yelena Stukalin, Haim Einat
BACKGROUND: One concern regarding animal models of psychopathology is unclear external validity. One way to establish external validity is to examine measures representing separate facets of the pathology with a battery of tests in the same cohort of animals. Additionally, utilizing the same animals in a battery of tests can help to reduce the number of animals in research. However, issues had been raised regarding the analysis of data coming from batteries and the standard practice is to analyze each test separately...
November 27, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29191085/effects-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-on-anxiety-like-behavior-in-socially-isolated-rats
#20
Yasuyo Oshima, Tasuku Watanabe, Shun Endo, Shuichi Hata, Tsuyoshi Watanabe, Kyoichi Osada, Asako Takenaka
The effects of fish oil for improving mental health have been reported. The present study was undertaken to compare the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on anxiety-like behavior using a rat model. Experimental diets enriched in EPA or DHA as glycerides were prepared. Rats were exposed to social isolation stress and fed the experimental diet for 14 days. The results of behavioral tests revealed that rats fed the EPA-enriched diet exhibited less anxiety-like behavior than rats fed the control or DHA-enriched diets...
December 1, 2017: Bioscience, Biotechnology, and Biochemistry
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