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https://www.readbyqxmd.com/read/27861199/heart-rate-reduction-with-adjusted-dose-ivabradine-in-patients-undergoing-coronary-computed-tomographic-angiography-a-randomized-trial
#1
Blaž Kacijan, Zala Novak, Borut Jug, Maja Dolenc Novak, Matjaž Vrtovec, Barbara Gužič Salobir
OBJECTIVE: Our prospective, randomized, open-label study assessed the efficacy of a heart rate-lowering, adjusted-dose protocol with ivabradine prior to coronary computed tomographic angiography (CCTA). METHODS: Patients undergoing CCTA were randomized to 7 days of adjusted-dose ivabradine or standard care (ie, no additional medication). Heart rate and β-blocker and antianxiety medication use on the day of the CCTA were recorded. RESULTS: One hundred one patients were randomized (mean age, 60 [SD, 13] years; 66% women)...
November 17, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27858904/pattern-of-psychotropic-medications-use-in-a-cohort-of-patients-with-uninvestigated-dyspepsia-undergoing-upper-endoscopy-a-retrospective-study
#2
Maria Pina Dore, Laura Piras, Liliana Lorettu, Giovanni Mario Pes
The prevalence of psychotropic drugs usage is growing in the general population. Moreover, patients with dyspeptic symptoms are increasingly referred to the use of psychiatric and antianxiety drugs in addition to the primary medical treatment. The focus of this observational retrospective study was to investigate the burden of psychotropic drugs usage in a cohort of patients with uninvestigated dyspepsia scheduled for esophagogastroduodenoscopy.Medical records of 11,275 patients (4377 men and 6898 women, age range 18-96 years) referred to the Gastroenterology Unit of the University of Sassari, Sardinia, between January 1995 and December 2013 were reviewed...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27845264/antianxiety-activity-guided-isolation-and-characterization-of-bergenin-from-caesalpinia-digyna-rottler-roots
#3
Jitender Singh, Ashwani Kumar, Anupam Sharma
ETHNOPHARMACOLOGICAL RELEVANCE: Caesalpinia digyna Rottler (Caesalpiniaceae) roots have been used traditionally for soothing nerves, as nervine tonic and febrifuge. The aim of the present study was to isolate the antianxiety constituent(s) from C. digyna roots following bioactivity guided fractionation approach. MATERIAL AND METHODS: Bioactive fraction F4 was subjected to column chromatography to get three sub-fractions (F4.1-F4.3) and a compound CD2. CD1 and CD2 were characterized using standard spectral techniques...
November 11, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27790460/blonanserin-a-novel-antianxiety-and-antidepressant-drug-an-experimental-study
#4
Ramchandra Prabhakar Limaye, Aditi Nitin Patil
INTRODUCTION: Many psychiatric disorders show signs and symptoms of anxiety and depression. A drug with both, effects and lesser adverse effects is always desired. Blonanserin is a novel drug with postulated effect on anxiety and depression. AIM: The study was aimed to evaluate the effect of Blonanserin on anxiety and depression in animal models. MATERIALS AND METHODS: By using elevated plus maze test and forced swimming test, the antianxiety and antidepressant effects were evaluated...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27737817/isolation-characterization-and-quantification-of-an-anxiolytic-constituent-mahanimbine-from-murraya-koenigii-linn-spreng-leaves
#5
Jyoti Dahiya, Jitender Singh, Ashwani Kumar, Anupam Sharma
ETHNOPHARMACOLOGICAL RELEVANCE: Leaves of M. koenigii Linn. Spreng (Rutaceae) have been used as traditional medicine for anxiety disorders. Aim of the study was to isolate antianxiety principle(s) from the leaves of M. koenigii using bioactivity guided approach. MATERIAL AND METHODS: Hydroalcoholic extract of M. koenigii leaves was prepared using soxhlet apparatus, and the same was evaluated for antianxiety activity at 250, 500 and 750mg/kg, po, using Elevated plus-maze (EPM)...
October 10, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27721543/anxiolytic-antidepressant-and-antistress-activities-of-the-aqueous-extract-of-cinnamomum-tamala-nees-and-eberm-in-rats
#6
Gayaprasad Upadhyay, Sarvesh Khoshla, Ramoji Kosuru, Sanjay Singh
OBJECTIVE: The current study was designed to explore anxiolytic, antidepressant, and antistress actions of Cinnamomum tamala (CT) leaves (aqueous extract) in rats. MATERIALS AND METHODS: Behavioral procedures of anxiety, depression, and stress were assessed in rats. CT (100, 200, and 400 mg/kg) was given once a daily for 7 days via oral route and the efficacy was matched by those elicited by lorazepam (1 mg/kg, p.o.), imipramine (10 mg/kg, p.o.), and Withania somnifera (100 mg/kg, p...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27639708/effect-of-methanol-extract-of-trigonella-foenum-graecum-l-seeds-on-anxiety-sedation-and-motor-coordination
#7
Tahira Assad, Rafeeq Alam Khan
Currently available anxiolytics cause numerous adverse effects and show craving and tolerance during long term treatment. Currently traditional medicines have been re-evaluated widely through work on various plant species. Numerous plants in traditional system show pharmacological activity with unlimited prospective for therapeutic use. Hence we planned to evaluate the effect of methanol extract of T. foenum-graecum L. seeds on anxiety, sedation and motor coordination in mice at different doses following 15 days of oral feeding...
September 17, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27549375/pharmacological-treatment-of-cannabis-related-disorders-a-narrative-review
#8
David A Gorelick
BACKGROUND: Cannabis is the most widely used illicit psychoactive substance world-wide, yet no medication is approved for the treatment of intoxication, withdrawal, or cannabis use disorder (CUD). OBJECTIVE: To comprehensively review the current state of knowledge. METHOD: Search of the PubMed electronic data base and review of reference lists of relevant articles to identify controlled clinical trials of pharmacological treatment. RESULTS: The search identified 4 trials for specific intoxication symptoms (none for global intoxication), 7 trials for withdrawal, and 12 phase II trials for CUD...
August 22, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27514298/sexual-dysfunction-due-to-psychotropic-medications
#9
REVIEW
Anita H Clayton, Andrew R Alkis, Nishant B Parikh, Jennifer G Votta
Sexual functioning is important to assess in patients with psychiatric illness as both the condition and associated treatment may contribute to sexual dysfunction (SD). Antidepressant medications, mood stabilizers, antipsychotics, and antianxiety agents may be associated with SD related to drug mechanism of action. Sexual adverse effects may be related to genetic risk factors, impact on neurotransmitters and hormones, and psychological elements. Effective strategies to manage medication-induced sexual dysfunction are initial choice of a drug unlikely to cause SD, switching to a different medication, and adding an antidote to reverse SD...
September 2016: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/27508815/-op-7a-06-treating-hypertensive-crises-between-guidelines-and-real-world-an-anti-hypertensive-role-of-anti-anxiety-drugs
#10
M Gabba, F Salinaro, R Mussinelli, M Boldrini, A Raimondi, C Belotti, A Maggi, T Perrone, M A Bressan, S Perlini
OBJECTIVE: Current ESH Guidelines are extensively devoted to diagnosis, management and follow-up of arterial hypertension in the "chronic" setting, whereas less attention is given to the acute management of hypertensive crises, a group of potentially life-threatening complications. Moreover, epidemiological data concerning hypertensive crises are limited. DESIGN AND METHOD: During 2014, 457 consecutive patients with an initial systolic blood pressure (SBP) >170 mmHg and/or diastolic blood pressure (DBP) >110 mmHg were enrolled after being admitted to an Emergency Department (ED) serving a population of more than 50000 inhabitants, RESULTS: : Hypertensive crises represented 0...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27468734/acute-left-ventricle-failure-on-induction-of-anesthesia-a-case-report-of-reverse-stress-cardiomyopathy-presentation-diagnosis-and-treatment
#11
Sohail Ikram, Nashwa Saleem, Rana K Latif
Reverse takotsubo cardiomyopathy (TCM) is a less common variant of classic TCM that presents within a different patient profile and with its own hemodynamic considerations. A 46-year-old woman was admitted to our hospital for laryngoscopy and possible balloon dilatation for tracheal stenosis under general anesthesia. One year prior to this admission, the patient was admitted after a motor vehicle accident with subdural hematoma, subarachnoid hemorrhage, and fracture of the eighth thoracic vertebra. She underwent uneventful anesthesia for thoracic spine surgery and tracheostomy to help her wean from the ventilator during that admission...
October 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27413203/nutritional-and-therapeutic-perspectives-of-chia-salvia-hispanica-l-a-review
#12
REVIEW
Rahman Ullah, M Nadeem, A Khalique, M Imran, S Mehmood, A Javid, J Hussain
The ancient grain is becoming enormously popular in modern food regimen in many countries; the higher proportion of α-linolenic acid makes chia the superb source of omega-3 fatty (about 65 % of the oil content). Omega-3 fatty acid has been associated with a large number of physiological functions in human body. Chia seed is a potential source of antioxidants with the presence of chlorogenic acid, caffeic acid, myricetin, quercetin, and kaempferol which are believed to have cardiac, hepatic protective effects, anti-ageing and anti-carcinogenic characteristics...
April 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27401108/central-histaminergic-transmission-modulates-the-ethanol-induced-anxiolysis-in-mice
#13
Lokesh Verma, Nishant S Jain
Intrigued by the report demonstrating an increase in brain histamine levels by ethanol administration and central histamine transmission to affect the anxiety related behaviors, the present study examined the permissive role of central histaminergic transmission in the acute anxiolytic-like effect of the ethanol on elevated plus maze (EPM) in mice. Results demonstrated that prior administration of the agents that are known to enhance the brain histamine transmission, i.e. low dose of histamine (0.1μg/mouse, i...
October 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27354909/lysergic-acid-diethylamide-a-drug-of-use
#14
REVIEW
Saibal Das, Preeti Barnwal, Anand Ramasamy, Sumalya Sen, Somnath Mondal
Lysergic acid diethylamide (LSD), described as a classical hallucinogen, began its journey from the middle of the last century following an accidental discovery. Since then, it was used as a popular and notorious substance of abuse in various parts of the world. Its beneficial role as an adjunct to psychotherapy was much unknown, until some 'benevolent' experiments were carried out over time to explore some of its potential uses. But, many of its effects were unclear and seemed to be a psychedelic enigma. In this review article, we have described the receptor pharmacology, mechanism of action, effects and adverse effects of LSD on the normal body system...
June 2016: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/27353547/synthesis-and-biological-evaluation-of-2-fluoro-and-3-trifluoromethyl-phenyl-piperazinylalkyl-derivatives-of-1h-imidazo-2-1-f-purine-2-4-3h-8h-dione-as-potential-antidepressant-agents
#15
Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Agata Siwek, Monika Głuch-Lutwin, Gabriela Starowicz, Grzegorz Kazek, Anna Partyka, Anna Wesołowska, Karolina Słoczyńska, Elżbieta Pękala, Maciej Pawłowski
A series of 2-fluoro and 3-trifluoromethylphenylpiperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione (4-21) were synthesized and evaluated for their serotonin (5-HT1A/5-HT7) receptor affinity and phosphodiesterase (PDE4B and PDE10A) inhibitor activity. The study enabled the identification of potent 5-HT1A, 5-HT7 and mixed 5-HT1A/5-HT7 receptor ligands with weak inhibitory potencies for PDE4B and PDE10A. The tests have been completed with the determination of lipophilicity and metabolic stability using micellar electrokinetic chromatography (MEKC) system and human liver microsomes (HLM) model...
June 29, 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/27293469/jujuboside-a-protects-h9c2-cells-from-isoproterenol-induced-injury-via-activating-pi3k-akt-mtor-signaling-pathway
#16
Dandan Han, Changrong Wan, Fenghua Liu, Xiaolong Xu, Linshu Jiang, Jianqin Xu
Jujuboside A is a kind of the saponins isolated from the seeds of Ziziphus jujuba, which possesses multiple biological effects, such as antianxiety, antioxidant, and anti-inflammatory effects; however, its mediatory effect on isoproterenol-stimulated cardiomyocytes has not been investigated yet. In this study, we tried to detect the protective effect and potential mechanism of JUA on ISO-induced cardiomyocytes injury. H9C2 cells were treated with ISO to induce cell damage. Cells were pretreated with JUA to investigate the effects on the cell viability, morphological changes, light chain 3 conversion, and the activation of PI3K/Akt/mTOR signaling pathway...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27191614/the-therapeutic-voyage-of-pyrazole-and-its-analogs-a-review
#17
REVIEW
Mohemmed Faraz Khan, Mohammad Mumtaz Alam, Garima Verma, Wasim Akhtar, Mymoona Akhter, Mohammad Shaquiquzzaman
Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic categories viz. antianxiety, anti-inflammatory, antipsychotic, anticancer, antiobesity, analgesic, antipyretic etc. has made it an indispensable anchor for design and development of new pharmacological agents. Owing to the development of novel and new pyrazole based therapeutic agents at a faster pace, there is a need to couple the latest information with previously available information to understand status of this moiety in medicinal chemistry research...
September 14, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27143891/patterns-of-psychotropic-medication-use-in-inpatient-and-outpatient-psychiatric-settings-in-saudi-arabia
#18
Fahad D Alosaimi, Abdulhadi Alhabbad, Mohammed F Abalhassan, Ebtihaj O Fallata, Nasser M Alzain, Mohammad Zayed Alassiry, Bander Abdullah Haddad
OBJECTIVE: To study the pattern of psychotropic medication use and compare this pattern between inpatient and outpatient psychiatric settings in Saudi Arabia. METHOD: This cross-sectional observational study was conducted between July 2012 and June 2014 on patients seeking psychiatric advice at major hospitals in five main regions of Saudi Arabia. Male (n=651) and female (n=594) patients who signed the informed consent form and were currently or had been previously using psychotropic medications, irrespective of the patient's type of psychiatric diagnosis and duration of the disease, were included...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27133721/electronic-health-record-availability-and-anxiety-treatment-in-office-based-practices
#19
Jeffrey S Harman, Jon Mills, Robert L Cook, Christopher A Harle
OBJECTIVE: This study compared the probability of receiving anxiety treatment during a physician visit to primary care practices with and without an electronic health record (EHR). METHODS: The 2007-2010 National Ambulatory Medical Care Survey was used to identify visits for anxiety (N=290). The outcome was receipt of anxiety treatment. The independent variable was the presence of a fully functioning EHR. Logistic regression was used to conduct the analysis. RESULTS: Patients who were seen in practices with a fully functioning EHR had lower odds of being offered antianxiety medication (adjusted odds ratio [AOR]=...
October 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27121715/synthesis-and-antinociception-activities-of-some-novel-derivatives-of-phencyclidine-with-substituted-aminobenzothiazoles
#20
Abbas Ahmadi, Mohsen Khalili, Behrooz Mirza, Mojtaba Mohammadi-Diz, Farnaz Azami-Lorestani, Parisa Ghaderi, Babak Nahri-Niknafs
Phencyclidine (PCP) as well as the analogues has indicated several pharmacological behaviors like analgesic, anticonvulsant, antianxiety, antidepressant depending on the dose and species examined. They interact with some neurotransmitter systems in the central nervous system like particular affinity for PCP sites in NMDA receptors or dopamine uptake blocking or both. In this study, due to analgesic properties of aminobenzothiazoles family, piperidine ring of PCP was replaced with electron-donating and electron-withdrawing substituted aminobenzothiazoles (1-4) for obtaining new analogues (II-V) with more analgesic activities...
April 28, 2016: Mini Reviews in Medicinal Chemistry
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