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management of thyroid nodules

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https://www.readbyqxmd.com/read/29428041/the-sonographic-subcentimeter-malignant-thyroid-nodule-what-does-it-stand-for
#1
Annette Pascual Marrero, Alvaro Gracia, William Méndez
Thyroid cancer management has moved to less extensive surgery in lesions with favorable criteria. Our study evaluated if the sonographic (US) size of thyroid nodules is a reliable criterion to determine the extent of surgery in patients with papillary thyroid carcinoma (PTC). A retrospective study was performed to evaluate thyroid nodules measuring <10 mm in the preop sonogram with a permanent pathology of PTC. Patients were subdivided into two groups based on the US size: A (1-5 mm) and B (6-10 mm). Statistical correlations were made for the presence of the following unfavorable criteria: multifocality, capsular invasion, angio/lymphatic invasion, extrathyroidal invasion, and presence of metastases...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29406334/hmga2-gene-expression-in-fine-needle-aspiration-samples-of-thyroid-nodules-as-a-marker-for-preoperative-diagnosis-of-thyroid-cancer
#2
Ivan Šamija, Neven Mateša, Sanja Kožaj, Ivana Majstorović, Ante Bolanča, Zvonko Kusić
There is a great interest in molecular markers that would help in the preoperative diagnosis of malignant thyroid nodules in cases of indeterminate fine-needle aspiration cytology. The aim of this study was to determine the diagnostic accuracy of HMGA2 gene expression in discriminating benign from malignant thyroid nodules. In this study, 237 preoperative thyroid fine-needle aspiration samples were analyzed prospectively for the expression of the HMGA2 gene by real-time reverse transcription polymerase chain reaction...
February 5, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29398434/effect-of-implementing-community-of-practice-modified-thyroid-imaging-reporting-and-data-system-on-reporting-adherence-and-number-of-thyroid-biopsies
#3
Tetyana Maniuk, Ania Z Kielar, Joseph P O'Sullivan, Mohamed El-Khodary, Heather Lochnan, Bibianna Purgina, Michael J Odell
RATIONALE AND OBJECTIVES: Thyroid nodules are common in the population, although the rate of malignancy is relatively low (5%-15%). The purpose of this study was to determine if introducing a modified standardized reporting format and management algorithm (Thyroid Imaging Reporting and Data System [TI-RADS]) affects radiologist reporting adherence, number of thyroid biopsies, and other measurable outcomes. MATERIALS AND METHODS: All thyroid biopsies performed over two 6-month periods were evaluated at a tertiary care hospital with Research Ethics Board approval...
February 2, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29396809/molecular-testing-of-nodules-with-a-suspicious-or-malignant-cytologic-diagnosis-in-the-setting-of-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#4
Kyle C Strickland, Markus Eszlinger, Ralf Paschke, Trevor E Angell, Erik K Alexander, Ellen Marqusee, Matthew A Nehs, Vickie Y Jo, Alarice Lowe, Marina Vivero, Monica Hollowell, Xiaohua Qian, Tad Wieczorek, Christopher A French, Lisa A Teot, Edmund S Cibas, Neal I Lindeman, Jeffrey F Krane, Justine A Barletta
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor characterized by frequent RAS mutations and an absence of the BRAF V600E mutation commonly seen in classical papillary thyroid carcinoma (cPTC). The ability to differentiate potential NIFTP/follicular variant of papillary thyroid carcinoma (FVPTC) from cPTC at the time of fine-needle aspiration (FNA) can facilitate conservative management of NIFTP. The aim of the current study was to investigate how molecular testing may add to cytologic assessment in the pre-operative differentiation of potential NIFTP/FVPTC and cPTC...
February 2, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29393868/galectin-3-the-impact-on-the-clinical-management-of-patients-with-thyroid-nodules-and-future-perspectives
#5
REVIEW
Armando Bartolazzi, Salvatore Sciacchitano, Calogero D'Alessandria
Galectins (S-type lectins) are an evolutionarily-conserved family of lectin molecules, which can be expressed intracellularly and in the extracellular matrix, as well. Galectins bind β-galactose-containing glycoconjugates and are functionally active in converting glycan-related information into cell biological programs. Altered glycosylation notably occurring in cancer cells and expression of specific galectins provide, indeed, a fashionable mechanism of molecular interactions able to regulate several tumor relevant functions, among which are cell adhesion and migration, cell differentiation, gene transcription and RNA splicing, cell cycle and apoptosis...
February 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29387413/incidental-finding-of-papillary-thyroid-carcinoma-on-ct-examination-of-mandibular-lesion-case-report
#6
Irfan Sugianto, Yoshinobu Yanagi, Hidenobu Konouchi, Miki Hisatomi, Shunsuke Okada, Babatunde O Bamgbose, Junichi Asaumi
The number of significant incidental findings identified on radiographic examinations has increased. In total, 169 patients, 87 males and 82 females, with a mean age of 67.3 years (range, 17-92 years), as well as 65 patients (38.5%), 43 (66.2%) female and 22 (33.8%) male had abnormal findings in the thyroid for one year in our institution. Thyroid nodules are the most common incidental findings on oral and maxillofacial evaluations. Computed tomography (CT) and magnetic resonance imaging (MRI) examination are frequently used to detect thyroid abnormality...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29380524/noninvasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-should-it-also-be-reclassified-in-children
#7
Rachel A Mariani, Rachel Kadakia, Nicoleta C Arva
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (noniEFVPTC) has low risk of adverse outcome in adults, warranting reclassification as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). In children, thyroid nodules have higher risk of malignancy and it is unknown if encapsulated FVPTC (EFVPTC) and infiltrative FVPTC (IFVPTC) tumors have different behavior. We analyzed the clinicopathologic features of follicular variant of papillary thyroid carcinoma (FVPTC) subtypes in our pediatric population to determine if noniEFVPTC has an indolent course as reported in adults...
January 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29369334/the-incidental-thyroid-nodule
#8
REVIEW
Sarah B Fisher, Nancy D Perrier
Incidental thyroid nodules that are found on an imaging study performed for reasons other than thyroid pathology represent a common scenario encountered by health care providers. The initial workup for these nodules comprises a thorough history and physical examination, thyroid function tests, a dedicated thyroid ultrasound, and fine-needle aspiration of any suspicious lesions. Management ranges from observation and reassurance to surgical resection and depends on the cytologic diagnosis. In cases of cytologically indeterminate or discordant nodules, surgical excision (lobectomy) offers a definitive diagnosis, although molecular testing or a reasonable period of observation may be useful as less invasive adjuncts...
January 25, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29354013/ultrasonographic-interval-changes-in-solid-thyroid-nodules-after-ultrasonography-guided-fine-needle-aspiration
#9
Ik Jung Hwang, Dong Wook Kim, Yoo Jin Lee, Hye Jung Choo, Soo Jin Jung, Hye Jin Baek
Objective: None of the previous studies have investigated the interval change in ultrasonography (US) features of solid thyroid nodules (STNs) after US-guided fine-needle aspiration (US-FNA). This study aimed to assess the prevalence and characteristics of US interval changes in STNs after US-FNA. Materials and Methods: This study included 257 STNs in 257 patients in whom thyroid US and initial US-FNA had been performed by two radiologists from January 2015 to June 2015...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29345225/indications-for-the-surgical-management-of-benign-goiter-in-adults
#10
Detlef K Bartsch, Markus Luster, Heinz J Buhr, Dietmar Lorenz, Christoph-Thomas Germer, Peter E Goretzki
BACKGROUND: Thyroidectomy is still three to six times more common in Germany than in the USA, Great Britain, and the Scandinavian countries. Thus, the question is often asked whether thyroidectomy in Germany is being performed for the correct indications. METHODS: This review is based on studies and guidelines containing information on the indications for surgery in benign goiter and Graves' disease; these publications were retrieved by a systematic literature search in the Medline and Cochrane Library databases (1990-2016)...
January 8, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29336606/update-on-molecular-testing-for-cytologically-indeterminate-thyroid-nodules
#11
Michiya Nishino, Marina Nikiforova
CONTEXT: - Approximately 15% to 30% of thyroid nodules that undergo fine-needle aspiration are classified as cytologically indeterminate, presenting management challenges for patients and clinicians alike. During the past several years, several molecular tests have been developed to reduce the diagnostic uncertainty of indeterminate thyroid fine-needle aspirations. OBJECTIVE: - To review the methodology, clinical validation, and recent peer-reviewed literature for 4 molecular tests that are currently marketed for cytologically indeterminate thyroid fine-needle aspiration specimens: Afirma, ThyroSeq, ThyGenX/ThyraMIR, and RosettaGX Reveal...
January 16, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29323546/validation-of-the-2015-american-thyroid-association-management-guidelines-for-thyroid-nodules-with-benign-cytologic-findings-in-the-era-of-the-bethesda-system
#12
Yeun-Yoon Kim, Kyunghwa Han, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y Park, Jin Young Kwak
OBJECTIVE: The purpose of this study is to investigate follow-up strategies for cytologically benign thyroid nodules according to size and ultrasound (US) pattern according to the 2015 American Thyroid Association (ATA) guidelines in the era of the Bethesda system. MATERIALS AND METHODS: This retrospective study included 1208 patients with 1230 nodules that were cytologically benign at initial fine-needle aspiration performed from June 2012 to December 2014. False-negative rates (FNRs) were calculated by considering nodule size and US pattern according to the 2015 ATA guidelines and were compared between nodules with the high-suspicion US pattern and nodules with the high- or intermediate-suspicion US patterns according to size...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29279153/inter-exam-agreement-and-diagnostic-performance-of-the-korean-thyroid-imaging-reporting-and-data-system-for-thyroid-nodule-assessment-real-time-versus-static-ultrasonography
#13
Jung Min Bae, Soo Yeon Hahn, Jung Hee Shin, Eun Young Ko
OBJECTIVE: To investigate the inter-exam agreement for thyroid nodule between real-time ultrasonography (US) assessment and retrospective US interpretation and to compare the diagnostic performance between two methods by using the most recently published guidelines for the US-based management of thyroid nodules, the Korean Thyroid Imaging Reporting and Data System (K-TIRADS). METHODS: The study included 253 nodules in 238 patients for the inter-exam agreement and 201 nodules in 190 patients for the diagnostic performance...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29249077/distinguishing-benign-from-malignant-thyroid-nodules-using-thyroid-ultrasonography-utility-of-adding-superb-microvascular-imaging-and-elastography
#14
Hye Shin Ahn, Jong Beum Lee, Mirinae Seo, Sung Hee Park, Byung Ihn Choi
OBJECTIVE: Thyroid nodules are common; however, malignancy is less than 7%. Therefore, additional techniques such as Doppler ultrasonography or elastography are used to improve diagnostic performance of conventional ultrasonography. We want to prospectively investigate the use of additional superb microvascular imaging (SMI) and strain elastography to B-mode ultrasound in thyroid nodules in distinguishing benign from malignant thyroid nodules. METHODS: We analyzed 52 thyroid nodules (malignant = 26, benign = 26) and reviewers scored the likelihood of malignancy for three data sets (i...
December 16, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29243502/evidence-based-management-of-incidental-focal-uptake-of-fluorodeoxyglucose-on-pet-ct
#15
Deborah Pencharz, Malavika Nathan, Thomas L Wagner
Focal incidental uptake, with or without CT abnormalities, is a common finding on FDG PET/CT and evidence based management for this type of uptake is lacking. This article reviews the evidence on focal incidental uptake including the incidence of malignancy, differential diagnosis and imaging criteria which can be used to further characterise it. The article focusses on PET rather than CT criteria. The strength of the evidence base is highly variable ranging from systematic reviews and meta-analyses to a virtual absence of evidence...
December 15, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29234625/insight-into-differentiated-thyroid-cancer-gross-pathological-specimen-shrinkage-and-its-influence-on-tnm-staging
#16
Alexis Lacout, Emmanuel Chamorey, Juliette Thariat, Mostafa El Hajjam, Carole Chevenet, Renaud Schiappa, Pierre Yves Marcy
Introduction: This study aimed at comparing thyroid cancer staging when taking into account the differences between the "T" assessment" using ultrasound (US) and histopathological measurements. Material and Methods: This retrospective study included all consecutive differentiated follicular thyroid cancer (DTC) and medullary thyroid cancer (MTC) patients who underwent postoperative histopathological staging assessment at a single institution. Anaplastic thyroid carcinomas were excluded from the present study...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29230133/invasive-insular-thyroid-carcinoma-presenting-as-nonparalytic-dysphonia
#17
Blake S Raggio, Blair M Barton, Maria C Grant, Judith A Fornadley, Jeffrey P Marino
Background: Patients with suspected thyroid malignancy often undergo preoperative laryngeal examination with a focus on vocal fold mobility. We present the unique case of a patient with invasive thyroid carcinoma who presented with dysphonia despite intact vocal fold motion. Case Report: A 73-year-old female with a remote thyroid lobectomy presented with dysphonia. Thyroid ultrasound and fine-needle aspiration revealed a 1.1-cm nodule consistent with a colloid cyst...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29201322/the-diagnostic-value-of-fine-needle-aspiration-in-comparison-with-frozen-section-in-thyroid-nodules-a-20-year-study
#18
Sepideh Siadati, Seyed Mozafar Rabiee, Ebrahim Alijanpour, Mohammad Ali Bayani, Novin Nikbakhsh
Background: Fine needle aspiration (FNA) is the most important method in the diagnosis of thyroid nodules before surgery. Recently, the efficiency of FNA in thyroid nodule management has been debatable. On the other hand, intraoperative frozen section (FS) has been used to confirm the diagnosis of FNA and select the proper surgical approach. In this regard, the present study aimed to assess the diagnostic value of FNA as compared to FS in the diagnosis of thyroid nodules. Methods: This retrospective study was performed on 69 patients with FNA and FS and histopathological examination from 1993 to 2014 in Babol, northern Iran...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29189861/-study-and-management-of-thyroid-nodes-by-non-specialist-physicians-soched-consensus
#19
Hernán Tala, René E Díaz, José Miguel Domínguez Ruiz-Tagle, Jorge Sapunar Zenteno, Pedro Pineda, Patricia Arroyo Albala, Marcela Barberán, Patricio Cabané, Francisco Cruz Olivos, Patricio Gac E, Andrea Glasinovic Pizarro, Hernán E González, Francisca Grob, Maria Soledad Hidalgo Valle, Rodrigo Jaimovich, Alejandra Lanas, Claudio Liberman, Maite Lobo Guiñez, Arturo Madrid
The thyroid nodule is a frequent cause of primary care consultation. The prevalence of a palpable thyroid nodule is approximately 4-7%, increasing up to 67% by the incidental detection of nodules on ultrasound. The vast majority are benign and asymptomatic, staying stable over time. The clinical importance of studying a thyroid nodule is to exclude thyroid cancer, which occurs in 5 to 10% of the nodules. The Board of SOCHED (Chilean Society of Endocrinology and Diabetes) asked the Thyroid Study Group to develop a consensus regarding the diagnostic management of the thyroid nodule in Chile, aimed at non-specialist physicians and adapted to the national reality...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29181988/diagnostic-performances-and-interobserver-agreement-according-to-observer-experience-a-comparison-study-using-three-guidelines-for-management-of-thyroid-nodules
#20
Jieun Koh, Soo-Yeon Kim, Hye Sun Lee, Eun-Kyung Kim, Jin Young Kwak, Hee Jung Moon, Jung Hyun Yoon
Background The differences regarding categorization of thyroid nodules among different guidelines may affect the diagnostic performances and agreement among observers. Purpose To compare the diagnostic performances and agreements between observers with various degree of experience when applying different guidelines for stratifying thyroid nodules using suspicious ultrasonography (US) features. Material and Methods This retrospective study included 370 thyroid nodules (≥10 mm). Four observers, grouped as experienced and inexperienced, evaluated the US features and made final assessments according to the Kim criteria, Thyroid Imaging Reporting and Data System (TIRADS) by Kwak et al...
January 1, 2017: Acta Radiologica
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