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paraganglioma carotid

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https://www.readbyqxmd.com/read/28321772/paragangliomas-of-the-head-and-neck-an-overview-from-diagnosis-to-genetics
#1
Michelle D Williams
Paragangliomas (PGL) develop from the parasympathetic system in the head and neck (HN) and arise primarily in four distinct areas: Carotid body, vagal, middle ear, and larynx. Globally, the diagnosis and morphologic features are the same regardless of anatomic site, however the incidence, frequency of genetic alterations/syndromes and differential diagnosis vary. It is now recognized that nearly 40% of all HN PGLs are hereditary, including a significant subset without a known family history. Now pathologists are central to the evaluation for diagnosis and further management of patients with HNPGLs...
March 20, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28298947/glomus-vagale-tumour-can-it-be-diagnosed-only-on-sonography
#2
Shuchi Bhatt, Pooja Verma, Neha Meena, Anupama Tandon, Nadeem Tanveer, Divya Bansal
Vagal paragangliomas are rare benign tumors accounting for only 3% of head and neck paragangliomas and arise from vagal ganglions, predominately the nodose ganglion in the carotid sheath. Imaging plays an important role in their diagnosis, differentiation from more common lesions presenting in the carotid space, and management. MRI is the method of choice for investigation when paragangliomas are clinically suspected. The typical salt-and-pepper appearance in T1-weighted images is well known but not specific to paragangliomas...
March 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28262005/parotid-or-carotid-misled-by-site
#3
Ruchita Tyagi, Manish Munjal, Pavneet Kaur, Harpreet Kaur, Neena Sood
We present an interesting scenario where a 64 years old male presented with a long standing painless, infra-auricular swelling, which had progressively increased in size. Based on the site, the clinical impression was of a salivary gland lesion and FNAC was performed. The smears were unusually cellular and had necrotic background. The cytological diagnosis was a cystic neoplasm of salivary gland, possibly mucoepidermoid carcinoma. Warthin's tumor was also kept in differential. However, the radiological investigations, which were made available after the FNAC report were conflicting with cytological diagnosis of a malignancy and were characteristic of a carotid body tumor, generally a benign neoplasm...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28245992/overt-and-subclinical-baroreflex-dysfunction-following-bilateral-carotid-body-tumor-resection-pathophysiology-diagnosis-and-implications-for-management
#4
REVIEW
Michael G Z Ghali, Visish M Srinivasan, Ehab Hanna, Franco DeMonte
Carotid body paragangliomas are rare, usually benign, tumors arising from glomus cells of the carotid body. Bilateral involvement is present in ∼5% of sporadic cases and up to one-third of familial cases. In the majority of patients undergoing bilateral resection of carotid body tumors (CBTs), a condition known as baroreflex failure syndrome (BFS) develops following resection of the second tumor characterized by headache, anxiety, emotional lability, orthostatic lightheadedness, hypertension, and tachycardia...
February 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28187022/carotid-body-paraganglioma-a-rare-tumor-with-serious-anesthetic-challenges
#5
Angela T Truong, Sudip Thakar, Dam-Thuy Truong
No abstract text is available yet for this article.
February 10, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28109497/management-of-carotid-body-tumor-in-pediatric-patients-a-case-report-and-review-of-the-literature
#6
Apanisile Ifeoluwa, István Lázár, Éva Szövördi, Tamás Karosi
Carotid body tumors (CBTs) are rare types of extra-adrenal paragangliomas, which originate from the neuroendocrine cells of the adventitial layer of carotid bifurcation. An 8-year-old girl was admitted to our department with left-sided and pulsating neck swelling, which progressively grew over several months. The patient had no family history of CBTs. Computed tomography (CT) and CT angiography (CTA) scans revealed a contrast material enhancing, hypervascularized mass involving the left carotid bifurcation, internal carotid artery (ICA), and external carotid artery (ECA), respectively...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28028970/diagnostic-and-therapeutic-difficulties-in-carotid-body-paragangliomas-based-on-clinical-experience-and-a-review-of-the-literature
#7
Karolina Dorobisz, Tadeusz Dorobisz, Hanna Temporale, Tomasz Zatoński, Marzena Kubacka, Mariusz Chabowski, Andrzej Dorobisz, Tomasz Kręcicki, Dariusz Janczak
BACKGROUND: Paragangliomas are rare neuroendocrine tumors, representing 0.03% of all tumors. Half of them develop in the head and neck, and among these 50% are sporadic cervical tumors. OBJECTIVES: The aim of the study was to carry out an epidemiological and clinical analysis of paraganglioma patients diagnosed and treated at the authors' clinics between 1985 and 2014. MATERIAL AND METHODS: The medical data of 47 patients were analyzed. All the patients were qualified for surgery...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28001459/long-term-effect-of-adrenalectomy-on-cardiovascular-remodeling-in-patients-with-pheochromocytoma
#8
Bohumil Majtan, Tomáš Zelinka, Ján Rosa, Ondřej Petrák, Zuzana Krátká, Branislav Štrauch, Vladimír Tuka, Alice Vránková, David Michalský, Květoslav Novák, Dan Wichterle, Jiří Widimský, Robert Holaj
CONTEXT: Catecholamines may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial and myocardial wall due to various mechanisms. Reversibility of this process has not been studied on both structures simultaneously. OBJECTIVE: This study aimed to clarify the long-term effect of catecholamines' excess normalization on carotid and myocardial wall changes in patients with pheochromocytoma or functional paraganglioma (PHEO) after tumor removal...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27923112/the-double-mandibular-osteotomy-for-vascular-and-tumor-surgery-of-the-parapharyngeal-space
#9
Thomas Schlieve, Eric R Carlson, Michael Freeman, Ryan Buckley, Josh Arnold
PURPOSE: The purposes of this study are to describe our experience using a double mandibular osteotomy for access to the parapharyngeal space in vascular and tumor surgery and to report on the outcomes and complications of this procedure. PATIENTS AND METHODS: We designed and implemented a case series to review the medical records of all patients treated with a double mandibular osteotomy for parapharyngeal space access from 1994 to 2016. Patient demographic characteristics, indications for the procedure, outcomes, and complications were recorded...
November 15, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27902883/metastatic-carotid-body-paraganglioma-of-lungs-and-lymph-nodes-unsuspected-diagnosis-on-ebus-tbna
#10
Kalpana Kumari, Deepali Jain, Rohit Kumar, Anant Mohan, Rakesh Kumar
Paragangliomas are tumors that originate from the extra-adrenal chromaffin and nonchromaffin cells of neural crest origin. Lymph node metastases are common, while distant metastases to lung, liver, and bone are rare events and usually occur in the presence of a long standing clinically evident primary tumor. Primary diagnosis of paraganglioma at a metastatic site without a known primary is a diagnostic challenge. We report a case of an adult woman with incidentally detected metastasis to bilateral lungs from an occult carotid body paraganglioma, which presented a cytopathological diagnostic dilemma on EBUS-TBNA from paratracheal lymph nodes...
April 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27887852/morphological-and-functional-imaging-of-neck-paragangliomas
#11
J-P Guichard, N Fakhry, J Franc, P Herman, C-A Righini, D Taieb
OBJECTIVE: To review the optimal techniques for localization and characterization of neck paragangliomas (PGL). MATERIAL AND METHODS: Systematic review of the literature from the PubMed/Medline database. RESULTS: Neck PGL are hypervascular tumours essentially arising from paraganglionic tissue situated at the carotid bifurcation (carotid body) and along the vagus nerve. Morphological and functional imaging are indicated to confirm the diagnosis, identify multifocal disease and for local and regional staging...
November 22, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27871494/current-surgical-management-of-carotid-body-tumors
#12
Victor J Davila, James M Chang, William M Stone, Richard J Fowl, Thomas C Bower, Michael L Hinni, Samuel R Money
BACKGROUND: Carotid body tumors (CBTs) are rare. Management guidelines may include genetic testing for succinate dehydrogenase (SDH) mutations. We performed an institutional review of the surgical management of CBT. METHODS: A retrospective analysis (1994-2015) of CBT excisions at our institution was performed. Data obtained included demographics, genetic testing (if performed), intraoperative details, postoperative morbidity, and long-term outcomes. Data from the first CBT excision were included in patients with bilateral tumors...
December 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27867439/evaluation-of-head-and-neck-paragangliomas-by-computed-tomography-in-patients-with-pheochromocytoma-paraganglioma-syndromes
#13
Ilona Michałowska, Anna Lewczuk, Jarosław Ćwikła, Aleksander Prejbisz, Urszula Swoboda-Rydz, Mariusz I Furmanek, Małgorzata Szperl, Andrzej Januszewicz, Mariola Pęczkowska
BACKGROUND: Hereditary head and neck paragangliomas (HNP) are very often associated with pheochromocytoma-paraganglioma syndromes, which are caused by mutations in genes encoding subunits of succinate dehydrogenase (SDHx) complex. The aim of this study was to determine the frequency and location of HNP among SDHx carriers. MATERIAL/METHODS: A total of 72 patients with SDHx mutations underwent computed tomography examinations of the head and neck. HNP were present in 44 (61...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27858099/-percutaneous-embolization-and-ultrasound-scissors-for-removal-of-a-carotid-body-tumor
#14
I I Venara-Vulpe, B Morisod, G B Morand, J-B Zerlauth, C Simon
Paragangliomas are highly vascularized usually benign neoplasms originating from the sympathoadrenal and parasympathetic paraganglia of the autonomic nervous system. When resectable, the management of these tumors consists of surgical ablation preceded by transarterial embolization. The aim of this article is to describe a novel treatment strategy combining intralesional percutaneous embolization with dissection using ultrasound scissors. The case of a 74-year-old women presenting with a Shamblin type III carotid body paraganglioma is presented...
December 2016: HNO
https://www.readbyqxmd.com/read/27833982/an-evaluation-on-multidisciplinary-management-of-carotid-body-paragangliomas-a-report-of-seven-cases
#15
Dragoş Cătălin Jianu, Silviana Nina Jianu, Andrei Gheorghe Marius Motoc, Traian Flavius Dan, Mărioara Poenaru, Sorina Tăban, Octavian Marius CreŢu
Carotid body paragangliomas (CBPGLs) are a rare neoplasms of the neuroendocrine system that affect the carotid glomus. The aim of this study is to improve their management in our Departments. This retrospective analysis reports family history, clinical presentation, imaging diagnostics, Shamblin classification, surgical treatment, complications, and the outcome of seven patients with CBPGLs. All lesions were represented by a painless cervical mass, with no functional or bilateral neck tumors. One patient had two different localizations (the second one was a glomus tumor of the right prelachrymal sac), and a family history for CBPGL...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27556663/treatment-of-head-and-neck-paragangliomas
#16
REVIEW
Kenneth Hu, Mark S Persky
BACKGROUND: Commonly occurring in the head and neck, paragangliomas are typically benign, highly vascular neoplasms embryologically originating from the extra-adrenal paraganglia of the neural crest. Frequently, these tumors are associated with the vagus or tympanic plexus nerve or the carotid artery, or jugular bulb. Their clinical presentation can vary across a wide spectrum of signs and symptoms. METHODS: We reviewed and compared standard treatment approaches for paragangliomas of the head and neck...
July 2016: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/27402879/parent-of-origin-tumourigenesis-is-mediated-by-an-essential-imprinted-modifier-in-sdhd-linked-paragangliomas-slc22a18-and-cdkn1c-are-candidate-tumour-modifiers
#17
Attje S Hoekstra, Ruben D Addie, Cor Ras, Reza M Seifar, Claudia A Ruivenkamp, Inge H Briaire-de Bruijn, Frederik J Hes, Jeroen C Jansen, Eleonora P M Corssmit, Willem E Corver, Hans Morreau, Judith V M G Bovée, Jean-Pierre Bayley, Peter Devilee
Mutations in SDHD and SDHAF2 (both located on chromosome 11) give rise to hereditary paraganglioma almost exclusively after paternal transmission of the mutation, and tumours often show loss of the entire maternal copy of chromosome 11. The 'Hensen' model postulates that a tumour modifier gene located on chromosome 11p15, a region known to harbour a cluster of imprinted genes, is essential to tumour formation. We observed decreased protein expression of the 11p15 candidate genes CDKN1C, SLC22A18 and ZNF215 evaluated in 60 SDHD-mutated tumours compared to normal carotid body tissue and non-SDH mutant tumours...
July 8, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27376229/sympathetic-chain-schwannoma-resembling-carotid-body-tumour
#18
Tallat Najeeb, Musaddiq Khan
Schwannomas are rare, benign nerve sheath tumours of parapharyngeal space. Differential diagnosis should include salivary gland tumours, paragangliomas, neurofibromas, and metastatic lymph nodes. The tumours may arise from vagus nerve and cervical sympathetic chain (CSC). Diagnosis is usually made by imaging techniques: contrast CT, magnetic resonance imaging (MRI), and magnetic resonance angiography (MRA). Fine needle aspiration cytology (FNAC) is useful diagnostic procedure but poor results are seen in neurogenic tumours...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27371607/mediastinal-paraganglioma-fed-by-the-left-circumflex-artery
#19
José María González-Santos, María Elena Arnáiz-García, Ángel Muñoz-Herrera, Javier López-Rodríguez
A 60-year-old male patient who previously underwent carotid and jugular paraganglioma resections was referred because of a mediastinal recurrence at the root of the great vessels. Coronary angiography confirmed the circumflex artery of the left coronary artery as the feeding artery of the tumour. The patient underwent surgery due to the tumour's location and malignant potential. Upon mass resection, histopathological examination characterized the tumour as a secondary paraganglioma. Neuroendocrine tumours arising from chromaffin tissues at the extra-adrenal paraganglions of the autonomic nervous system are termed paragangliomas...
November 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27355479/-percutaneous-phil%C3%A2-embolization-for-preoperative-therapy-of-carotid-body-paragangliomas
#20
G Psychogios, A Berlis, B Märkl, T Schaller, M N Psychogios, J Zenk
Introduction: Paragangliomas are rare tumors representing a therapeutic challenge. In particular, the surgical removal may lead to life-threatening bleeding. The preoperative percutaneous embolization is an alternative that allows a high closure rate of tumor-feeding vessels in a short intervention time and thus significantly reduces intraoperative bleeding probability. Complete tumor resection is facilitated thereby. The use of a new non-adhesive liquid embolic agent is presented here. Methods: A 50-year old patient presented with 4 cm large paraganglioma of the carotid body (Shamblin II)...
January 2017: Laryngo- Rhino- Otologie
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