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https://www.readbyqxmd.com/read/28541267/choroidal-melanoma-sector-melanocytosis-and-retinal-pigment-epithelial-microdetachments-in-birt-hogg-dub%C3%A3-syndrome
#1
Charlotte L Marous, Molly R Marous, R Joel Welch, Jerry A Shields, Carol L Shields
PURPOSE: Birt-Hogg-Dubé Syndrome (BHDS) is a rare autosomal dominant condition that can predispose patients to numerous cutaneous fibrofolliculomas and other cutaneous lesions, pulmonary cysts with spontaneous pneumothorax, and multifocal renal tumors and cancer. The genetic mutations responsible for BHDS are related to tumor suppression and the mammalian target of rapamycin (mTOR) pathway. Previous reports of the ocular findings in BHDS include eyelid fibrofolliculomas, "flecked chorioretinopathy," and one report of choroidal melanoma...
May 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28537014/usefulness-of-pet-ct-for-early-detection-of-internal-malignancies-in-patients-with-muir-torre-syndrome-report-of-two-cases
#2
Yui Ishiguro, Shigenori Homma, Tadashi Yoshida, Yosuke Ohno, Nobuki Ichikawa, Hideki Kawamura, Hiroo Hata, Satoru Kase, Susumu Ishida, Hiromi Okada-Kanno, Kanako C Hatanaka, Akinobu Taketomi
BACKGROUND: Muir-Torre syndrome (MTS) is a rare autosomal dominant genodermatosis caused by mutations in mismatch repair genes. It is characterized by the presence of at least one sebaceous skin tumor associated with internal malignancies. Whether positron emission tomography/computed tomography (PET/CT) is useful for the detection of malignancies in patients with MTS has not been determined. We herein report two cases in which PET/CT was useful for the diagnosis and follow-up of internal malignancies in patients with MTS...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28507440/ocular-basal-cell-carcinoma-a-brief-literature-review-of-clinical-diagnosis-and-treatment
#3
REVIEW
Yingyun Shi, Renbing Jia, Xianqun Fan
Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consist of surgery, vismodegib, radiotherapy and imiquimod. Surgical excision using Mohs micrographic surgery or wide surgical excision with frozen section margin control is the first consideration for treatment of periocular BCC...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28474158/two-stage-rapid-exenteration-reconstruction-to-allow-early-radiation-therapy-for-an-aggressive-orbital-cancer
#4
Sagar Y Patel, Diana A Tamboli, Ronald Mancini
PURPOSE: Describe a novel two-stage orbital exenteration technique using an INTEGRA dermal regeneration matrix. METHODS: A 63-year-old Hispanic male presented with multiple invasive right eyelid masses that incisional biopsy revealed was infiltrative basal cell carcinoma. The patient underwent a right orbital exenteration without lid sparing. An INTEGRA graft was sutured in place to cover the defect at the time of surgery and allowed to vascularize for 3 weeks...
May 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28472011/multifocal-ocular-surface-squamous-neoplasia
#5
Swati Singh, Ruchi Mittal, Suryasnata Rath
A 64-year-old healthy female presented with a papillomatous limbal lesion involving 6 clock hours of superior limbus and diffuse involvement of upper tarsal conjunctiva of left eye of 6 months duration. Excision of superior limbal lesion on histopathology showed carcinoma in situ with focal breach in basement membrane and moderate degree of differentiation. The surgical base and margins were uninvolved. The tarsal lesion was initially treated with subconjunctival interferon alpha 2b (IFN alpha 2b) (3 cycles of IFN alpha 2b) with poor response...
May 2, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28471957/aggressively-progressing-primary-undifferentiated-pleomorphic-sarcoma-in-the-eyelid-a-case-report-and-review-of-the-literature
#6
Won Choi, Jae Ha Hwang, Ga Eon Kim, Kyung Chul Yoon
RATIONALE: Undifferentiated pleomorphic sarcoma is extremely rare in the head and neck area, and the aggressive nature of this tumor has not been previously described. PATIENT CONCERNS: Therefore, we report a unique case of a very rapidly growing primary undifferentiated pleomorphic sarcoma in the eyelid. A 67-year-old woman presented with a left lower lid mass. She had no previous history of surgery, skin malignancy, or radiation to the eyelid. On initial presentation, the patient showed a 2 × 1 × 1 cm firm, yellow nodule in the left lower eyelid...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28469319/fine-needle-aspiration-cytology-of-solitary-fibrous-tumor-of-the-orbit
#7
Vani Krishnamurthy, S Suchitha, M Asha, G V Manjunath
Solitary fibrous tumor (SFT) is a distinct and a rare spindle cell neoplasm, commonly known to occur in the pleura and other serosal sites. With the advent of immunohistochemistry, varied extraserosal sites are being recognized as common locations for this rare tumor. We report a case of SFT in a 50-year-old male patient who presented with multiple swellings in the eyelid, with emphasis on the cytological features.
April 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28467283/pigmented-tumors-in-fallow-deer-dama-dama-11-cases
#8
Kelly L Hughes, Rob J Bildfell, Benjamin Alcantar
Pigmented tumors have been reported infrequently in captive deer. We document herein the clinical progression and gross and histopathologic features of pigmented tumors diagnosed as melanoma and pigmented schwannoma in 11 white fallow deer ( Dama dama). Affected animals were part of a captive herd maintained at a drive-through park in southern Oregon and were 5-17 y of age during the study period (2004-2013). Primary lesion locations included periocular, perineal, and neck tissues, with cutaneous and internal metastases later identified at autopsy in some cases of malignant melanoma...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28454286/suspected-tumor-to-meningioma-metastasis-a-case-report
#9
Iuri Santana Neville, Davi Fontoura Solla, Arthur Maynart Oliveira, Cesar Casarolli, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
Tumor-to-meningioma metastasis (TMM) is a fairly uncommon phenomenon. Only 7 cases of prostate cancer with TMM have previously been described in the literature. The present study aimed to report a case of prostate cancer TMM, and to discuss the relevant clinical and neuroimaging aspects of this condition. A 68-year-old patient presented with headaches, poor visual acuity in the left eye and ipsilateral eyelid droop 3 years after a Simpson II resection of a left sphenoid wing meningioma. Computed tomography revealed a hyperdense area suggestive of a recurrent left sphenoid wing meningioma...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28413552/trigeminocardiac-reflex-preceding-development-of-postoperative-superior-orbital-fissure-syndrome
#10
Rudrashish Haldar, Prakhar Gyanesh, Arun Srivastava, Guru Prasad Bettaswamy
The superior orbital fissure syndrome (SOFS) is a rare condition presenting as painful unilateral opthalmoplegia, ptosis, pupillary dilatation and anesthesia of the upper eyelid and forehead. It has been described after facial trauma. Other etiologies include infections, tumors or spontaneous hemorrhages in the retro-orbital space. Occurrence of SOFS after surgery in the skull base has not been described before. We recently encountered a case where a young female developed SOFS following surgery for cerebrospinal fluid (CSF) rhinorrhea...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28407252/combined-endonasal-and-eyelid-approach-for-management-of-extensive-frontal-sinus-inverting-papilloma
#11
Monirah Albathi, Murugappan Ramanathan, Andrew P Lane, Kofi D O Boahene
OBJECTIVES: Sinonasal inverting papilloma (IP) is a benign but locally aggressive mucosal neoplasm with a high recurrence rate. Extension into the frontal sinus presents surgical challenges for endonasal resection. This study presents an orbitofrontal approach for managing extensive IP. STUDY DESIGN: Case series. METHODS: Four patients seen between 2012 and 2016 with biopsy-proven IP with lateral frontal sinus extension underwent a combined endonasal and transpalpebral approach for tumor resection...
April 13, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28399341/lymphoproliferative-tumors-of-the-ocular-adnexa
#12
Robert M Verdijk
The ocular adnexa include the eyelids, conjunctiva, lacrimal apparatus, and orbital soft tissue. One percent of all lymphomas and approximately 8% of all extranodal lymphomas arise in the ocular adnexa and their incidence is increasing. Reactive lymphoid hyperplasia comprises 16% of all lymphoproliferative tumors of the ocular adnexa. The relative frequencies of ocular adnexal lymphoma presentation are in the orbit, 37%; conjunctiva, 29%; lacrimal apparatus, 20%; and eyelid, 14%. The most frequent primary lymphoma types of the ocular adnexa are extranodal marginal zone lymphoma, 62%; follicular lymphoma, 17%; and diffuse large B-cell lymphoma, 10%...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399340/what-s-new-in-eyelid-tumors
#13
Nora Silverman, Roman Shinder
Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Given the constraints of the anatomy and function of the eyelids, excision with negative margins and reconstruction can be challenging. In cases of significant tissue invasion or metastasis, complete tumor removal may not be possible...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28374274/bilateral-extensive-nodular-xanthelasma-palpebrarum-an-infrequent-case-report
#14
Pei Wang, Qingli Luo, Li Tang
PURPOSE: To report a rare case of extensive bilateral xanthelasma palpebrarum (XP). A 70-year-old man presented with nodular lesions of his eyelids for 12 years. The skin changes began with his left lower eyelid and progressively spread to both lateral-inferior and infero-medial periorbital areas. The lesions were yellow nodules that were hard, extensive, multiple and coalescent. METHOD: The tumors of this patient's eyelids underwent resection and tissue was processed for light microscopic examination...
April 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28373462/expression-of-anti-apoptotic-protein-bag3-in-human-sebaceous-gland-carcinoma-of-the-eyelid
#15
Tatsuya Yunoki, Yoshiaki Tabuchi, Atsushi Hayashi
BACKGROUND: Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), has been shown to play a role in anti-apoptosis of various malignant tumors. In this study, the expression of BAG3 was examined in human sebaceous gland carcinoma of the eyelid. MATERIALS AND METHODS: The expression of BAG3 was evaluated by immunohistochemistry of surgical samples from 5 patients with sebaceous gland carcinoma in the eyelid. RESULTS: BAG3 was positive diffusely in the cytoplasm in all patients...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373404/precancer-atlas-to-drive-precision-prevention-trials
#16
Avrum Spira, Matthew B Yurgelun, Ludmil Alexandrov, Anjana Rao, Rafael Bejar, Kornelia Polyak, Marios Giannakis, Ali Shilatifard, Olivera J Finn, Madhav Dhodapkar, Neil E Kay, Esteban Braggio, Eduardo Vilar, Sarah A Mazzilli, Timothy R Rebbeck, Judy E Garber, Victor E Velculescu, Mary L Disis, Douglas C Wallace, Scott M Lippman
Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality will take a fundamental rethinking and deep understanding of premalignant biology. In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), integrating multi-omics and immunity - basic tenets of the neoplastic process. The biology of neoplasia caused by germline mutations has led to paradigm-changing precision prevention efforts, including: tumor testing for mismatch repair (MMR) deficiency in Lynch syndrome establishing a new paradigm, combinatorial chemoprevention efficacy in familial adenomatous polyposis (FAP), signal of benefit from imaging-based early detection research in high-germline risk for pancreatic neoplasia, elucidating early ontogeny in BRCA1-mutation carriers leading to an international breast cancer prevention trial, and insights into the intricate germline-somatic-immunity interaction landscape...
April 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28364339/characteristics-of-orbital-lymphoma-a-clinicopathological-study-of-26-cases
#17
Daniel Briscoe, Christine Safieh, Yokrat Ton, Hava Shapiro, Ehud I Assia, Dvora Kidron
OBJECTIVE: Evaluation of the medical data of patients with orbital and adnexal lymphoma. DESIGN: Cohort study of all cases diagnosed with orbital or adnexal lymphoma at Meir Medical Center between 1993 and 2007. PARTICIPANTS: Twenty-six patients, with intraorbital or subconjunctival masses with orbital involvement, were examined and followed up between 1 and 8 years. MATERIALS AND METHODS: Examined data included: clinical presentation, age, gender, imaging, tumor location, surgical management, and pathological diagnosis...
March 31, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28353472/orbital-schwannoma-radiographic-and-histopathologic-correlation-in-15-cases
#18
Renelle Pointdujour-Lim, Sara E Lally, Jerry A Shields, Ralph C Eagle, Carol L Shields
PURPOSE: To evaluate the relationship between radiographic and histopathologic features of orbital schwannoma. METHODS: Retrospective review of 15 patients with orbital schwannoma managed at an ocular oncology service. RESULTS: The mean patient age at the time of presentation was 42 years old (median 40, range 15-64 years). The orbital schwannoma was found incidentally (n = 2) or with symptoms of proptosis (n = 2), blurred vision (n = 3), pain (n = 3), eyelid swelling (n = 2), diplopia (n = 2), or headache (n = 1)...
March 28, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350693/prognostic-value-of-the-staging-system-for-eyelid-tumors-in-the-7th-edition-of-the-american-joint-committee-on-cancer-staging-manual
#19
Joshua Ford, Sudip Thakar, Bradley Thuro, Bita Esmaeli
PURPOSE: To determine the prognostic value of the staging criteria for eyelid tumors in the 7th edition of the American Joint Committee on Cancer (AJCC) staging manual and to determine, for each type of eyelid tumor, which AJCC T categories are associated with increased risk of nodal metastasis and thus potential usefulness of sentinel lymph node biopsy. METHODS: Systematic review and analysis of articles found by searching PubMed and Google Scholar using the search terms "AJCC," "eyelid," "carcinoma," and "melanoma...
March 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28331425/apocrine-adenocarcinoma-occurring-on-the-chin
#20
Hiromi Higaki-Mori, Kazunari Sugita, Reiko Tsutsumi, Koji Adachi, Yuichi Yoshida, Osamu Yamamoto
We report a case of adenocarcinoma affecting the chin of a 48-year-old man. The tumor showed signs of apocrine differentiation and had infiltrated the muscle. The patient had no history or clinical evidence of breast cancer. We made a diagnosis of cutaneous apocrine adenocarcinoma. Apocrine adenocarcinoma rarely arises in areas with scarce apocrine glands. We reviewed the literature on apocrine adenocarcinoma of the face in areas other than the eyelids and auditory canal, where specialized apocrine glands are present...
March 2017: Yonago Acta Medica
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