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https://www.readbyqxmd.com/read/28221292/dermatofibroma-of-the-eyelid-immunohistochemical-diagnosis
#1
Frederick A Jakobiec, Fouad R Zakka, Yufei Tu, Suzanne K Freitag
A 66-year-old man developed a painless 2 mm to 3 mm recurrent nodule at the left upper eyelid margin. Excision disclosed a spindle cell lesion without frank atypia or mitotic activity growing in a twisted fascicular pattern often referred to as storiform. All the surgical margins were involved with tumor. Immunohistochemistry demonstrated that many of the constituent spindle and dendritic tumor cells were CD34, factor XIIIa, and CD 163, the latter 2 being biomarkers for monocytic lineage. The lesion was diagnosed as a dermatofibroma rather than a fibrous histiocytoma, a term that should be reserved for more aggressive lesions of deeper fascial planes...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28204937/a-new-approach-to-upper-eyelid-reconstruction
#2
A Bulla, C Vielà, L Fiorot, A Bolletta, E Pancrazi, G V Campus
BACKGROUND: Reconstruction of large defects of the upper eyelid is challenging because of its complex anatomy and specialized function. The aim of this work is to develop a single-stage reconstruction procedure based on a new approach. The technique consists of the advancement of an orbicularis oculi myocutaneous flap designed within the blepharoplasty skin excision pattern. METHODS: After the tumor's excision is completed with clear margins, the borders of the flap are incised down to the submuscular plane inside the classical pattern of upper eyelid blepharoplasty...
February 15, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28203199/plexiform-neurofibroma-involving-the-lacrimal-gland
#3
Mikael Hofsli, Nico Gampenrieder, Steffen Heegaard
BACKGROUND: To present a rare case of a 2-year-old girl with neurofibromatosis type 1 (NF1) who presented with ptosis of the right upper eyelid along with a tumor in the eyelid. METHODS: A magnetic resonance imaging scan of the orbit revealed a solid tumor located extraconally at the site of the right lacrimal gland. A transcranial orbitotomy was performed. RESULTS: Histopathological examination demonstrated expanded nerve branches/fascicles cut in various planes in between normal lacrimal gland acini...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28203187/reconstructive-surgery-of-the-upper-eyelid-using-the-residual-tarsus-after-excision-of-sebaceous-gland-carcinoma
#4
Tatsuya Yunoki, Yasuhisa Nakamura, Chiharu Fuchizawa, Atsushi Hayashi
PURPOSE: To report a successful eyelid reconstruction performed using the residual tarsus after excision of a sebaceous gland carcinoma. CASE REPORT: An 86-year-old woman presented with a sebaceous gland carcinoma of the upper eyelid margin. After excision of the tumor, she underwent reconstructive surgery of the superior eyelid performed using the residual tarsus. Because the tumor was localized on the upper lid margin, a tarsus of about 4-5 mm in height remained after the excision; we therefore used the residual tarsus to reconstruct the upper eyelid...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28203109/a-b-cell-lymphoma-case-that-is-unclassifiable-and-intermediate-between-diffuse-large-b-cell-lymphoma-and-burkitt-lymphoma-of-lacrimal-gland
#5
Tatsuya Yunoki, Jun Murakami, Yukihiro Imagawa, Takahiko Nakajima, Atsushi Hayashi
A 60-year-old woman presented with acute eyelid swelling and a subcutaneous hemorrhage in the right eye. Magnetic resonance imaging showed a spherical tumor of the lacrimal gland. The tumor was removed by the Kroenlein method. We diagnosed as a B-cell lymphoma that is unclassifiable, and intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) (intermediate DLBCL/BL) based on its immunohistopathological examination and c-MYC/IgH rearrangement. We administered six cycles of dose-adjusted-EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin hydrochloride, and rituximab) therapy, and remission of the lymphoma was obtained...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28181367/periocular-breast-carcinoma-metastases-correlation-of-clinical-radiologic-and-histopathologic-features
#6
Natalie Homer, Frederick A Jakobiec, Anna Stagner, Mary Elizabeth Cunnane, Suzanne K Freitag, Aaron Fay, Michael K Yoon
IMPORTANCE: To describe presenting patterns of breast cancer metastases to the orbit and eyelids BACKGROUND: To provide clinical, radiographic, and pathologic correlations of breast metastases to the orbit or eyelids and evaluate radiographic volumetric orbital changes DESIGN: Retrospective review in an academic center PARTICIPANTS: Ten female patients with periocular metastatic breast carcinoma who were seen at the Massachusetts Eye and Ear Infirmary Oculoplastics Clinic METHODS: Retrospective review of patient records, imaging and pathology findings...
February 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28138125/face-transplant-in-an-advanced-neurofibromatosis-type-1-patient
#7
Łukasz Krakowczyk, Adam Maciejewski, Cezary Szymczyk, Krzysztof Oleś, Stanisław Półtorak
BACKGROUND The human face is a one-of-a-kind structure with unique morphology, complexity, and function, in which different subunits are not even similar to other parts of the body. Therefore, extended complex deficits of the face are usually difficult to reconstruct, and autologous tissue restoration is generally not able to give a satisfactory aesthetic and functional outcome. The main goal of face allotransplantation is to restore symmetry, contour, and appearance as well as function of the face, especially control of orbicularis oculi and oris muscle physiology...
January 31, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28058953/use-of-a-subdermal-plexus-flap-to-reconstruct-an-upper-eyelid-following-radical-tumor-resection-in-a-cat
#8
Filipe C Dias, Alan Danielski, Kate Forster, David L Williams
CASE DESCRIPTION A 15-year-old neutered male domestic shorthair cat was examined for treatment of a recurrent neoplastic mass in the left upper eyelid that had been excised 6 months earlier by the referring veterinarian. CLINICAL FINDINGS An apparently nonpainful firm cutaneous mass (approx 2 × 2 mm) was located on the lateral third of the left upper eyelid near the scar from the previous surgical excision. TREATMENT AND OUTCOME Approximately one-third of the left upper lip was used as a subdermal plexus (lip-to-lid) flap to cover the defect created by en bloc excision of the eyelid mass...
January 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28050325/the-importance-of-frozen-section-controlled-excision-in-recurrent-basal-cell-carcinoma-of-the-eyelids
#9
Berna Şahan, Ferda Çiftçi, Ferda Özkan, Vildan Öztürk
OBJECTIVES: To show the importance of frozen section-controlled excision to avoid the re-recurrence of recurrent basal cell carcinoma (BCC) of the eyelids. MATERIALS AND METHODS: Thirty-five cases who underwent eyelid tumor excision in different centers and were admitted to our clinic with recurrent eyelid tumors. Recurrent tumors were resected by excision 1-2 mm from the tumor's visible margin and sent to pathology for frozen section examination. Eyelid reconstructions with flap and graft were performed after confirming that the surgical margins were negative...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28048327/su-f-p-58-squamous-cell-and-basal-cell-carcinoma-of-the-skin-treated-with-a-freiburg-flap-applicator
#10
K Dou, B Li, M Jacobs, B Laser
PURPOSE: To treat squamous cell and basal cell carcinoma of the skin with the Freiburg flap applicator using a high dose rate modality of an Elekta Flexitron or MicroSelectron for radiation delivery by compensating the dose deviation resulting from the incomplete scatter environment. METHODS: Patients were selected to have lesions greater than or equal to 2cm. A mask might be needed depending on special locations. The lesions on the eyelid and face presented in this research were, however, treated without a mask...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28012879/dermatofibroma-of-the-eyelid-with-monster-cells
#11
Frederick A Jakobiec, Yufei Tu, Fouad R Zakka, Arthur K F Tong
Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A 64-year-old woman developed a recurrent lesion of the right lower eyelid. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted and hyperchromatic nucleus. The presence of these cells does not signify a malignant transformation. The background cells were either histiocytoid (many were adipophilin-positive), spindled cells, or dendritiform cells without mitoses...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27994815/pleomorphic-adenoma-of-the-eyelid-with-apocrine-gland-origin-an-atypical-location
#12
Renata T Rothwell, Sofia B Campelos, Sandra Prazeres
PURPOSE: To describe the clinical presentation and treatment of a patient with a cutaneous pleomorphic adenoma of the eyelid. CASE REPORT: A 73-year-old male patient presented with a nodular mass on the lateral third of his right upper eyelid, which had slowly enlarged over 10 years. Radiologic features were of an extra-conical mass, with no invasion of adjacent structures. An excisional biopsy of the lesion was performed. The histopathological examination revealed a biphasic tumor, composed of tubules with a double layer of epithelial cells arranged in a chondromyxoid stroma...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27990744/-en-face-ex-vivo-reflectance-confocal-microscopy-to-help-the-surgery-of-basal-cell-carcinoma-of-the-eyelid
#13
Marine Espinasse, Elisa Cinotti, Damien Grivet, Bruno Labeille, Virginie Prade, Catherine Douchet, Frédéric Cambazard, Gilles Thuret, Philippe Gain, Jean Luc Perrot
BACKGROUND: Fluorescence confocal microscopy (FCM) is a recent imaging technique for the examination of surgical cutaneous specimens and has been suggested as a fast alternative to Mohs micrographic surgery. Up-to-date it has been used in the fluorescence mode and with vertical sections of the specimen margins. The aim of this study was to evaluate FCM in the reflectance mode and with a horizontal ("en face") scanning of the surgical specimen in a series of basal cell carcinoma (BCC) of the eyelid...
December 19, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27956720/indication-for-and-limitation-of-the-facial-dismasking-flap-approach-for-skull-base-surgery-to-achieve-the-best-esthetical-and-functional-results
#14
Tomoyuki Yano, Mutsumi Okazaki, Kentaro Tanaka, Atsunobu Tsunoda, Masaru Aoyagi, Seiji Kishimoto
BACKGROUND: The facial dismasking flap (FDF) approach to operations on the deep skull base region consists of a coronal incision and a circumpalpebral incision. This approach provides a wide surgical field for extirpation of deep extended craniofacial tumors without leaving any undesirable scars on the face. Therefore, the FDF approach can provide satisfactory esthetical and functional results. Meanwhile, in some cases, especially in patients with a history of skull base surgery or orbital extension, patients are not fully satisfied even when the FDF approach is used...
January 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27906855/periocular-basal-cell-carcinoma-predictors-for-recurrence-and-infiltration-of-the-orbit
#15
Alena Furdova, Pavol Lukacko
PURPOSE: To present the proportion of patients with periocular basal cell carcinoma (BCC) who underwent orbital exenteration and to evaluate the significance of the risk factors. DESIGN: Retrospective, comparative, interventional case series. METHODS: Data of all patients with BCC between 2008 and 2014 were reviewed for patient demographics, previous treatment options, tumor localization, and histopathologic subtype. RESULTS: In group of 256 patients, orbital exenteration underwent 7 patients (2...
January 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27894880/lymphoma-of-the-eyelid
#16
REVIEW
Frederik Holm Svendsen, Steffen Heegaard
Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B-cell lymphoma (18 cases-9%). T-cell lymphomas are most frequently mycosis fungoides (25 cases-13%), extranodal natural killer/T-cell, nasal-type lymphoma (12 cases-6%), and primary cutaneous anaplastic large-cell lymphoma (12 cases-6%)...
November 26, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27878368/-therapy-options-for-malignant-eyelid-tumors
#17
M Weiling, A Bergua, F E Kruse, L Holbach
Basal cell carcinomas are the most common malignant tumors of the eyelids. Patient history, clinical symptoms and signs, inspection, palpation and slit-lamp examination usually allow a working diagnosis; however, the clinical diagnosis requires histopathological confirmation and determination of the histopathological type. Squamous cell carcinomas, sebaceous gland carcinomas, melanomas and Merkel cell carcinomas can metastasize usually via the lymph vessels into the regional lymph nodes. Microscopically controlled excision of the primary tumor into healthy tissue is most commonly the first goal...
December 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27843900/separate-primary-melanomas-of-the-bulbar-conjunctiva-and-eyelid-skin-clinical-implications-of-multiple-primary-melanomas
#18
Frances A Jacinto, George H Fisher, Edgar M Espana, Ilya M Leyngold, Curtis E Margo
PURPOSE: We report a patient with previous in situ melanoma of the forehead skin who was referred for treatment of a bulbar conjunctival melanoma and a separate superficially invasive melanoma of the eyelid skin, and we offer a review of the biological and clinical implications of patients who have multiple primary melanomas. METHODS: This article offers a clinicopathological correlation with a review of the relevant literature. RESULTS: An 80-year-old white man was referred for evaluation of a suspicious conjunctival tumor and a lower-eyelid lesion...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27843279/unusual-presentation-of-ulcerative-postauricular-swelling-as-sebaceous-cell-carcinoma
#19
Prem Chand, Ashok Kumar, Paramjit Singh, Lakshay Singla
Sebaceous glands have high concentration over head and neck region. Despite high concentration, sebaceous cell adenoma and carcinomas are infrequent. Sebaceous cell carcinoma is an uncommon, cutaneous aggressive tumor arising from the sebaceous glands and seen almost exclusively on the eyelids (75%). It accounts for just 0.2-0.7% of all eyelid tumors in the USA and very few cases that have originated in areas other than the eyelids have been reported. A 67-year-old male presented with swelling (3 cm × 4 cm), on the right postauricular region, since about 1-month...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27828924/isolated-nonsyndromic-intraneural-neuroma-of-the-eyelid-skin
#20
Frederick A Jakobiec, Alia Rashid, Michael K Yoon
A 56-year-old man developed a 2 × 2 mm, yellow-orange painless, smooth-surfaced nodule in the middle third of his left upper eyelid. Microscopic evaluation disclosed a spindle cell tumor that was well circumscribed by a perineurium. The tumor cells manifested wavy, bland nuclei displaying comma-shaped and pointed ends. These cells were uniformly S100 positive. Immunohistochemical analysis further revealed an even dispersion of numerous dot-like neurofilaments diagnostic of an isolated intraneural neuroma...
November 2016: Ophthalmic Plastic and Reconstructive Surgery
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