keyword
https://read.qxmd.com/read/38021670/uncovering-the-cardiovascular-threat-a-comprehensive-examination-of-liver-fibrosis-and-subclinical-atherosclerosis-in-non-alcoholic-fatty-liver-disease
#21
REVIEW
Niketa Sharma, Swarupa Chakole, Bhushan Wandile
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global epidemic intricately linked to the rising tide of obesity and metabolic syndrome. This comprehensive review delves into the complex web of relationships between NAFLD, liver fibrosis, and subclinical atherosclerosis, shedding light on their interplay, shared risk factors, and clinical implications. NAFLD encompasses a spectrum of liver conditions, from the benign non-alcoholic fatty liver (NAFL) to the more severe non-alcoholic steatohepatitis (NASH), characterized by inflammation and hepatocellular injury...
October 2023: Curēus
https://read.qxmd.com/read/37999546/association-between-air-pollution-and-lipid-profiles
#22
REVIEW
Yi Zhang, Jiaqi Shi, Ying Ma, Nairui Yu, Pai Zheng, Zhangjian Chen, Tiancheng Wang, Guang Jia
Dyslipidemia is a critical factor in the development of atherosclerosis and consequent cardiovascular disease. Numerous pieces of evidence demonstrate the association between air pollution and abnormal blood lipids. Although the results of epidemiological studies on the link between air pollution and blood lipids are unsettled due to different research methods and conditions, most of them corroborate the harmful effects of air pollution on blood lipids. Mechanism studies have revealed that air pollution may affect blood lipids via oxidative stress, inflammation, insulin resistance, mitochondrial dysfunction, and hypothalamic hormone and epigenetic changes...
October 31, 2023: Toxics
https://read.qxmd.com/read/37986679/research-progress-on-the-effects-of-adverse-exposure-during-pregnancy-on-skeletal-muscle-function-in-offspring
#23
JOURNAL ARTICLE
Rui Liu, Jianzhong Sheng, Hefeng Huang
Skeletal muscle plays a crucial role in maintaining metabolic function, energy homeostasis, movement function, as well as endocrine function. The gestation period is a critical stage for the myogenesis and development of skeletal muscle. Adverse environmental exposures during pregnancy would impose various effects on the skeletal muscle health of offspring. Maternal obesity during pregnancy can mediate lipid deposition in skeletal muscle of offspring by affecting fetal skeletal muscle metabolism and inflammation-related pathways...
November 21, 2023: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://read.qxmd.com/read/37963998/pathophysiology-of-obesity-related-infertility-and-its-prevention-and-treatment-by-potential-phytotherapeutics
#24
REVIEW
V V Sathibabu Uddandrao, Parim Brahma Naidu, P Chandrasekaran, G Saravanan
BACKGROUND: Obesity is a complex multifactorial disease in which the accumulation of excess body fat has adverse health effects, as it can increase the risk of several problems, including infertility, in both men and women. Obesity and infertility have risen together in recent years. Against this background, the present review aims to highlight the impact of obesity on infertility and the underlying pathophysiology of obesity-related infertility (ORI) in men and women, and to provide readers with knowledge of current trends in the effective development of phytotherapeutics for its treatment...
November 14, 2023: International Journal of Obesity
https://read.qxmd.com/read/37929034/signaling-pathways-and-targeted-therapeutic-strategies-for-polycystic-ovary-syndrome
#25
REVIEW
Kexin Wang, Yanhua Li
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Although promising strides have been made in the field of PCOS over the past decades, the distinct etiologies of this syndrome are not fully elucidated. Prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins all contribute to the development of this intricate and highly heterogeneous metabolic, endocrine, reproductive, and psychological disorder. Moreover, interactions between androgen excess, insulin resistance, disruption to the hypothalamic-pituitary-ovary (HPO) axis, and obesity only make for a more complex picture...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37893188/epigenetics-in-heart-failure-role-of-dna-methylation-in-potential-pathways-leading-to-heart-failure-with-preserved-ejection-fraction
#26
REVIEW
Simon W Rabkin, Chenille N Wong
This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca2+ -ATPase, oxidative-nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation...
October 17, 2023: Biomedicines
https://read.qxmd.com/read/37886940/exploring-the-functional-basis-of-epigenetic-aging-in-relation-to-body-fat-phenotypes-in-the-norfolk-island-cohort
#27
JOURNAL ARTICLE
Thao Van Cao, Heidi G Sutherland, Miles C Benton, Larisa M Haupt, Rodney A Lea, Lyn R Griffiths
DNA methylation is an epigenetic factor that is modifiable and can change over a lifespan. While many studies have identified methylation sites (CpGs) related to aging, the relationship of these to gene function and age-related disease phenotypes remains unclear. This research explores this question by testing for the conjoint association of age-related CpGs with gene expression and the relation of these to body fat phenotypes. The study included blood-based gene transcripts and intragenic CpG methylation data from Illumina 450 K arrays in 74 healthy adults from the Norfolk Island population...
September 27, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/37854189/modulation-of-fetoplacental-growth-development-and-reproductive-function-by-endocrine-disrupters
#28
REVIEW
Sanjay Basak, Saikanth Varma, Asim K Duttaroy
Maternal endocrine homeostasis is vital to a successful pregnancy, regulated by several hormones such as human chorionic gonadotropin, estrogen, leptin, glucocorticoid, insulin, prostaglandin, and others. Endocrine stress during pregnancy can modulate nutrient availability from mother to fetus, alter fetoplacental growth and reproductive functions. Endocrine disrupters such as bisphenols (BPs) and phthalates are exposed in our daily life's highest volume. Therefore, they are extensively scrutinized for their effects on metabolism, steroidogenesis, insulin signaling, and inflammation involving obesity, diabetes, and the reproductive system...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37844863/phthalate-exposure-and-risk-of-metabolic-syndrome-components-a-systematic-review
#29
REVIEW
Celia Perez-Diaz, Maialen Uriz-Martínez, Carmen Ortega-Rico, Ester Leno-Duran, Rocío Barrios-Rodríguez, Inmaculada Salcedo-Bellido, Juan Pedro Arrebola, Pilar Requena
Metabolic syndrome is a cluster of conditions that increase the risk of cardiovascular disease, i.e. obesity, insulin resistance, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-c) levels and arterial hypertension. Phthalates are environmental chemicals which might influence the risk of the aforementioned disturbances, although the evidence is still controversial. To synthesize the evidence on the association between human phthalate exposure and metabolic syndrome or any of its components...
October 14, 2023: Environmental Pollution
https://read.qxmd.com/read/37781923/fto-fuels-diabetes-induced-vascular-endothelial-dysfunction-associated-with-inflammation-by-erasing-m6a-methylation-of-tnip1
#30
JOURNAL ARTICLE
Chuandi Zhou, Xinping She, Chufeng Gu, Yanan Hu, Mingming Ma, Qinghua Qiu, Tao Sun, Xun Xu, Haibing Chen, Zhi Zheng
Endothelial dysfunction is a critical and initiating factor of the vascular complications of diabetes. Inflammation plays an important role in endothelial dysfunction regulated by epigenetic modifications. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications in eukaryotic cells. In this research, we identified an m6A demethylase, fat mass and obesity-associated protein (FTO), as an essential epitranscriptomic regulator in diabetes-induced vascular endothelial dysfunction. We showed that enhanced FTO reduced the global level of m6A in hyperglycemia...
October 2, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37763315/epigenetic-aspects-of-a-new-probiotic-concept-a-pilot-study
#31
JOURNAL ARTICLE
Nina Okuka, Verena Schuh, Ulrike Krammer, Snezana Polovina, Mirjana Sumarac-Dumanovic, Neda Milinkovic, Ksenija Velickovic, Brizita Djordjevic, Alexander Haslberger, Nevena Dj Ivanovic
Several studies report the important role of an altered gut microbiota in the development of obesity, highlighting the potential use of probiotics in the treatment of obesity. The aim of this study is to investigate the effect of a novel probiotic approach on the expression of specific miRNAs and mRNAs associated with obesity in combination with the hypocholesterolemic octacosanol. Twenty overweight/obese women participated in a randomized, placebo-controlled, double-blind study and were randomly divided into two groups: the intervention group (daily one capsule containing Lactobacillus plantarum 299v (DSM9843), Saccharomyces cerevisiae var...
September 14, 2023: Life
https://read.qxmd.com/read/37762023/the-role-of-selected-epigenetic-pathways-in-cardiovascular-diseases-as-a-potential-therapeutic-target
#32
REVIEW
Anna Wołowiec, Łukasz Wołowiec, Grzegorz Grześk, Albert Jaśniak, Joanna Osiak, Jakub Husejko, Mariusz Kozakiewicz
Epigenetics is a rapidly developing science that has gained a lot of interest in recent years due to the correlation between characteristic epigenetic marks and cardiovascular diseases (CVDs). Epigenetic modifications contribute to a change in gene expression while maintaining the DNA sequence. The analysis of these modifications provides a thorough insight into the cardiovascular system from its development to its further functioning. Epigenetics is strongly influenced by environmental factors, including known cardiovascular risk factors such as smoking, obesity, and low physical activity...
September 6, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37738759/placental-dysfunction-in-obese-women-and-antenatal-surveillance
#33
REVIEW
Anjum Doshani, Justin C Konje
Obesity is a significant health concern worldwide and is associated with numerous health complications, including placental dysfunction during pregnancy. Placental dysfunction can lead to adverse outcomes for both the mother and the foetus, such as preeclampsia, gestational diabetes, preterm birth, and foetal growth restriction. Studies have shown that maternal obesity can lead to placental dysfunction through various mechanisms, including chronic inflammation, oxidative stress, and dysregulation of metabolic pathways...
December 2023: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/37726284/maternal-and-paternal-obesity-differentially-reprogram-the-ovarian-mitochondrial-biogenesis-of-f1-female-rats
#34
JOURNAL ARTICLE
Amina G Ramadan, Wafaa M Abdel-Rehim, Rasha A El-Tahan, Samar S Elblehi, Maher A Kamel, Sara A Shaker
Obesity has harmful consequences on reproductive outcomes and the rapid increase in obesity is assumed to be influenced by epigenetics and trans-generation effects. Our study aimed to explore the effect of maternal and/or paternal obesity on the ovarian tissues of the first-generation female offspring in rats. The study was conducted on 40 adult Wistar albino rats (20 males and 20 females). Obesity was induced by feeding them an obesogenic diet for 3 months. The pregnancy was induced in the females by mating with males in four combinations: healthy mother with healthy father (control parents, CP), healthy mother with obese fathers (OF), obese mothers with healthy father (OM), and obese mother with obese father (obese parents, OP)...
September 19, 2023: Scientific Reports
https://read.qxmd.com/read/37720354/dna-methylation-in-cancer-epigenetic-view-of-dietary-and-lifestyle-factors
#35
REVIEW
Mohsen Maleknia, Nooshin Ahmadirad, Fereshteh Golab, Yasmina Katebi, Arsh Haj Mohamad Ebrahim Ketabforoush
BACKGROUND: Alterations in DNA methylation play an important role in cancer development and progression. Dietary nutrients and lifestyle behaviors can influence DNA methylation patterns and thereby modulate cancer risk. INTRODUCTION: To comprehensively review available evidence on how dietary and lifestyle factors impact DNA methylation and contribute to carcinogenesis through epigenetic mechanisms. MATERIALS AND METHODS: A literature search was conducted using PubMed to identify relevant studies published between 2005 and 2022 that examined relationships between dietary/lifestyle factors and DNA methylation in cancer...
2023: Epigenetics Insights
https://read.qxmd.com/read/37714902/effects-of-obesity-and-of-weight-loss-following-bariatric-surgery-on-methylation-of-dna-from-the-rectal-mucosa-and-in-cell-free-dna-from-blood
#36
JOURNAL ARTICLE
Khalil ElGendy, Fiona C Malcomson, Sorena Afshar, Michael D Bradburn, John C Mathers
BACKGROUND: DNA methylation is an epigenetic mechanism through which environmental factors including nutrition and inflammation influence health. Obesity is a major modifiable risk factor for many common diseases including cardiovascular diseases and cancer. In particular, obesity-induced inflammation resulting from aberrantly-methylated inflammatory genes may drive risk of several non-communicable diseases including colorectal cancer (CRC). This study is the first to investigate the effects of weight loss induced by bariatric surgery (BS) on DNA methylation in the rectum and in cell-free DNA (cfDNA) from blood...
September 15, 2023: International Journal of Obesity
https://read.qxmd.com/read/37660305/gestational-diabetes-mellitus-genetic-factors-epigenetic-alterations-and-microbial-composition
#37
REVIEW
Dennise Lizárraga, Bruno Gómez-Gil, Teresa García-Gasca, Anaguiven Ávalos-Soriano, Livio Casarini, Azucena Salazar-Oroz, Alejandra García-Gasca
Gestational diabetes mellitus (GDM) is a common metabolic disorder, usually diagnosed during the third trimester of pregnancy that usually disappears after delivery. In GDM, the excess of glucose, fatty acids, and amino acids results in foetuses large for gestational age. Hyperglycaemia and insulin resistance accelerate the metabolism, raising the oxygen demand, and creating chronic hypoxia and inflammation. Women who experienced GDM and their offspring are at risk of developing type-2 diabetes, obesity, and other metabolic or cardiovascular conditions later in life...
September 3, 2023: Acta Diabetologica
https://read.qxmd.com/read/37651852/maternal-obesity-and-high-leptin-levels-prime-pro-inflammatory-pathways-in-human-cord-blood-leukocytes
#38
JOURNAL ARTICLE
Bernardo J Krause, Fabian A Vega-Tapia, Gustavo Soto-Carrasco, Isidora Lefever, Catalina Letelier, Claudia G Saez, Jose A Castro-Rodriguez
INTRODUCTION: Maternal obesity alters the immune function in the offspring. We hypothesize that maternal obesity and pro-inflammatory pathways induce leptin-related genes in neonatal monocytes, whereby high leptin levels enhance their inflammatory response. METHODS: Transcriptional profiles of cord blood leukocytes (CBL) in basal and pro-inflammatory conditions were studied to determine differentially expressed genes (DEG). The DNA methylation profile of CB monocytes (CBM) of neonates born to control BMI mothers and women with obesity was assayed to identify differentially methylated probes (DMP)...
October 2023: Placenta
https://read.qxmd.com/read/37649101/fathers-preconception-smoking-and-offspring-dna-methylation
#39
JOURNAL ARTICLE
Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C Dharmage, Svein Magne Skulstad, Sarah H Watkins, Matthew Suderman, Francisco Gómez-Real, Vivi Schlünssen, Cecilie Svanes, John W Holloway
BACKGROUND: Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic marks in offspring associated with father's preconception smoking. METHODS: We conducted epigenome-wide association studies (EWAS) in the RHINESSA cohort (7-50 years) on father's any preconception smoking (n = 875 offspring) and father's pubertal onset smoking < 15 years (n = 304), using Infinium MethylationEPIC Beadchip arrays, adjusting for offspring age, own smoking and maternal smoking...
August 31, 2023: Clinical Epigenetics
https://read.qxmd.com/read/37626900/the-transcription-factor-hoxa5-novel-insights-into-metabolic-diseases-and-adipose-tissue-dysfunction
#40
REVIEW
Luca Parrillo, Rosa Spinelli, Michele Longo, Federica Zatterale, Gianluca Santamaria, Alessia Leone, Michele Campitelli, Gregory Alexander Raciti, Francesco Beguinot
The transcription factor HOXA5 , from the HOX gene family, has long been studied due to its critical role in physiological activities in normal cells, such as organ development and body patterning, and pathological activities in cancer cells. Nonetheless, recent evidence supports the hypothesis of a role for HOXA5 in metabolic diseases, particularly in obesity and type 2 diabetes (T2D). In line with the current opinion that adipocyte and adipose tissue (AT) dysfunction belong to the group of primary defects in obesity, linking this condition to an increased risk of insulin resistance (IR) and T2D, the HOXA5 gene has been shown to regulate adipocyte function and AT remodeling both in humans and mice...
August 18, 2023: Cells
keyword
keyword
99824
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.