keyword
MENU ▼
Read by QxMD icon Read
search

Respiratory disease obesity

keyword
https://www.readbyqxmd.com/read/29127035/the-high-production-volume-fungicide-pyraclostrobin-induces-triglyceride-accumulation-associated-with-mitochondrial-dysfunction-and-promotes-adipocyte-differentiation-independent-of-ppar%C3%AE-activation-in-3t3-l1-cells
#1
Anthony L Luz, Christopher D Kassotis, Heather M Stapleton, Joel N Meyer
Pyraclostrobin is one of the most heavily used fungicides, and has been detected on a variety of produce, suggesting human exposure occurs regularly. Recently, pyraclostrobin exposure has been linked to a variety of toxic effects, including neurodegeneration and triglyceride (TG) accumulation. As pyraclostrobin inhibits electron transport chain complex III, and as mitochondrial dysfunction is associated with metabolic syndrome (cardiovascular disease, type II diabetes, obesity), we designed experiments to test the hypothesis that mitochondrial dysfunction underlies its adipogenic activity...
November 7, 2017: Toxicology
https://www.readbyqxmd.com/read/29120929/risk-factors-for-opioid-induced-respiratory-depression-and-failure-to-rescue-a-review
#2
Kapil Gupta, Arun Prasad, Mahesh Nagappa, Jean Wong, Lusine Abrahamyan, Frances Chung
PURPOSE OF REVIEW: The primary objective of this review is to identify the risk factors for opioid-induced respiratory depression (OIRD) in the postoperative period. RECENT FINDINGS: In the postoperative period, OIRD has often been reported resulting in morbidity and mortality. The risk factors which predispose surgical patients to increased risk of OIRD are not clearly defined. A literature search was performed for adult surgical patients who were prescribed opioids during their hospital stay and any available reports on postoperative respiratory depression/respiratory events...
November 7, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29118943/novel-therapies-for-perioperative-respiratory-complications
#3
REVIEW
Jahan Porhomayon, Leili Pourafkari, Ali El-Solh, Nader D Nader
Postoperative respiratory complications are of paramount clinical importance as they prolong the hospitalization, increase the costs of treatment and contribute to the perioperative mortality. Obesity, preexisting pulmonary disease and advanced age are known risk factors for developing postoperative respiratory complications, which affect exceeding number of patients. Hereby, we present a review on the pathogenesis of post-operative respiratory complications particularly in obese and older patients. We further focus on the standard management and emerging therapies for the post-operative respiratory complications...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29117118/diet-and-asthma-is-it-time-to-adapt-our-message
#4
REVIEW
Laurent Guilleminault, Evan J Williams, Hayley A Scott, Bronwyn S Berthon, Megan Jensen, Lisa G Wood
Asthma is a chronic respiratory disorder which is associated with airway inflammation. Environmental factors, in association with genetic susceptibility, play a critical role in asthma pathophysiology. Inhaled allergens, smoke exposure, indoor and outdoor air pollution are common triggers of asthma symptoms. Although the role of diet has clearly established mechanisms in diseases such as cardiovascular disease, type 2 diabetes, and cancer, it is not commonly identified as a causal factor in asthma. However, some dietary patterns, such as the Western diet, which includes a high intake of refined grains, processed and red meats, and desserts, have pro-inflammatory effects...
November 8, 2017: Nutrients
https://www.readbyqxmd.com/read/29115454/mycoleptodonoides%C3%A2-aitchisonii-suppresses-asthma-via-th2-and-th1-cell-regulation-in-an-ovalbumin%C3%A2-induced-asthma-mouse-model
#5
Soon-Young Lee, Chun-Sik Bae, Ji-Hye Seo, Seung Sik Cho, Min-Suk Bae, Deuk-Sil Oh, Dae-Hun Park
Asthma is a chronic respiratory disease related to hyper‑responsiveness. The majority of patients suffer mild symptoms, however, some cases, especially in the young and the elderly, can lead to death by apnea. Mycoleptodonoides atichisonii (M. atichisonii) is an edible mushroom that has previously been reported to possess several bioactive properties, such as the synthesis of nerve growth factors, anti‑obesity effects and the ability to prevent cell death. In the current study, the authors evaluated the anti‑asthmatic effects of M...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29079731/involvement-of-er-stress-pi3k-akt-activation-and-lung-fibroblast-proliferation-in-bleomycin-induced-pulmonary-fibrosis
#6
Han-Shui Hsu, Chen-Chi Liu, Jiun-Han Lin, Tien-Wei Hsu, Jyuan-Wei Hsu, Kelly Su, Shih-Chieh Hung
Pulmonary fibrosis is characterized by fibroblast proliferation and extracellular matrix remodelling, leading to respiratory insufficiency. The mechanisms underlying this progressive and devastating disease remain unclear. Conditions that can impair the function of the endoplasmic reticulum (ER) cause accumulation of unfolded or misfolded proteins, resulting in ER stress and activation of the unfolded protein response (UPR). ER stress has been implicated in many conditions including cancer, diabetes, obesity, and inflammation...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066903/fat-embolism-after-fractures-in-duchenne-muscular-dystrophy-an-underdiagnosed-complication-a-systematic-review
#7
REVIEW
David Feder, Miriam Eva Koch, Beniamino Palmieri, Fernando Luiz Affonso Fonseca, Alzira Alves de Siqueira Carvalho
Duchenne muscular dystrophy is the most frequent lethal genetic disease. Several clinical trials have established both the beneficial effect of steroids in Duchenne muscular dystrophy and the well-known risk of side effects associated with their daily use. For many years it has been known that steroids associated with ambulation loss lead to obesity and also damage the bone structure resulting in the bone density reduction and increased incidence of bone fractures and fat embolism syndrome, an underdiagnosed complication after fractures...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29054851/changes-in-the-venous-pulse-waveform-in-pericardial-effusion-revealed-by-doppler-echocardiography-of-the-superior-vena-cava
#8
Benoy N Shah, Dhrubo J Rakhit
No abstract text is available yet for this article.
December 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/29048927/early-origins-of-asthma-role-of-microbial-dysbiosis-and-metabolic-dysfunction
#9
Fernando D Martinez, Stefano Guerra
Asthma is a developmental disease that affects airway growth and is characterized by inappropriate responses to a variety of environmental stimuli. Recent advances point to two altered early life pathways as major determinants of asthma risk. In the "microbial" pathway, pre- and post-natal exposures to microbiota-loaded farm environments block gene-virus interactions (e.g., interactions between risk alleles in chromosome 17q21 and lower respiratory illnesses [LRI] by rhinovirus) that are associated with asthma development...
October 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29039444/vaspin-protects-against-lps%C3%A2-induced-ards-by-inhibiting-inflammation-apoptosis-and-reactive-oxygen-species-generation-in-pulmonary-endothelial-cells-via-the-akt-gsk%C3%A2-3%C3%AE-pathway
#10
Di Qi, Daoxin Wang, Chunrong Zhang, Xumao Tang, Jing He, Yan Zhao, Wang Deng, Xinyu Deng
Acute respiratory distress syndrome (ARDS) is characterized by uncontrolled extravasation of protein‑rich fluids, which is caused by disruption and dysfunction of the barrier of pulmonary endothelial cells (ECs). Visceral adipose tissue‑derived serine protease inhibitor (vaspin) is a novel adipokine with pleiotropic properties, which has been reported to exert beneficial effects against obesity‑associated systemic vascular diseases; however, its effects on ARDS remain unknown. In the present study, mice were subjected to systemic administration of adenoviral vector expressing vaspin (Ad‑vaspin) to examine its effects on lipopolysaccharide (LPS)‑induced ARDS in vivo...
October 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29019017/leptospirosis-associated-catastrophic-respiratory-failure-supported-by-extracorporeal-membrane-oxygenation
#11
Tamara Cantwell, Andrés Ferre, Nicolette Van Sint Jan, Rodrigo Blamey, Jorge Dreyse, Cristian Baeza, Rodrigo Diaz, Tomás Regueira
A previously healthy, 39-year-old obese farmer, arrived hypotensive and tachycardic, with fever, myalgia, headache, abdominal pain, diarrhea, and progressive dyspnea. Ten days before symptoms onset, he was in direct contact with mice and working in a contaminated drain. Patient laboratory showed acute kidney injury and thrombocytopenia. Chest X-ray exhibited bilateral diffuse interstitial infiltrates. First-line empirical antibiotics were started and influenza discarded. Patient evolved with severe respiratory failure, associated with hemoptysis, and rapidly severe hemodynamic compromise...
October 10, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29016794/epidemiology-of-chronic-respiratory-diseases-and-associated-factors-in-the-adult-italian-population
#12
Gianluigi Ferrante, Sandro Baldissera, Stefano Campostrini
Background: Detailed epidemiology of Chronic Respiratory Diseases (CRDs) and of their risk and protective factors is needed to plan preventive interventions to reduce the burden of CRDs on population health. This study determines the prevalence of doctor-diagnosed CRDs and its associated factors in the adult Italian population. Methods: Data was collected from adults participating in the ongoing cross-sectional Italian Behavioural Risk Factor Surveillance System (PASSI) between 2013 and 2015...
July 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28993936/the-influence-of-body-composition-on-pulmonary-rehabilitation-outcomes-in-chronic-obstructive-pulmonary-disease-patients
#13
Pichapong Tunsupon, M Jeffery Mador
INTRODUCTION: Alterations in body composition are commonly present in chronic obstructive pulmonary disease (COPD). The hypothesis of this study is that COPD patients would achieve clinical benefits after pulmonary rehabilitation (PR) independent of muscle mass depletion or body weight. METHODS: We conducted a retrospective cohort study using single-frequency bioelectrical impedance analysis (BIA) for assessment of fat-free mass (FFM) depletion (muscle depletion)...
December 2017: Lung
https://www.readbyqxmd.com/read/28990428/retrospective-review-of-comorbid-conditions-in-a-multidisciplinary-pediatric-weight-management-clinic
#14
Christine Thang, Margaret Whitley, Nilufar Izadpanah, Daniel DeUgarte, Wendy Slusser
A retrospective medical chart review was conducted of patients enrolled in the Fit for Healthy Weight Clinic (Fit Clinic). At initial evaluation, comorbidities were identified by the patient and pediatrician. The number of comorbidities increased with age among patients. In reviewing the differences among the number of identified comorbidities among grade school age and adolescent patients, increases of 30% were observed in gastrointestinal-associated, 23% in psychiatric, 18% in endocrine, 16% in cardiovascular, and 14% in respiratory comorbidities...
October 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28987445/immunogenicity-and-safety-of-an-inactivated-quadrivalent-influenza-vaccine-co-administered-with-a-23-valent-pneumococcal-polysaccharide-vaccine-versus-separate-administration-in-adults-%C3%A2-50years-of-age-results-from-a-phase-iii-randomized-non-inferiority-trial
#15
Opokua Ofori-Anyinam, Geert Leroux-Roels, Mamadou Drame, Annelies Aerssens, Cathy Maes, Arshad Amanullah, Anne Schuind, Ping Li, Varsha K Jain, Bruce L Innis
INTRODUCTION: We compared co-administration versus separate administration of an inactivated quadrivalent influenza vaccine (IIV4) with a 23-valent pneumococcal polysaccharide vaccine (PPV23) in adults at high risk of complications of influenza and pneumococcal infection. METHODS: This phase III, placebo-controlled, observer-blind trial (NCT02218697) was conducted in France and Belgium during the 2014-2015 influenza season. Adults≥50years of age meeting their country's vaccination recommendations were randomized 1:1 to co-administration or separate administration...
October 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28983937/factors-associated-with-change-in-health-related-quality-of-life-among-individuals-treated-with-long-term-mechanical-ventilation-a-six-year-follow-up-study
#16
Heidi Markussen, Sverre Lehmann, Roy M Nilsen, Gerd K Natvig
AIMS: To examine changes and explanatory variables for changes in health-related quality of life in patients treated with long-term mechanical ventilation over a six-year period. BACKGROUND: Long-term mechanical ventilation is a treatment for individuals with chronic hypercapnic respiratory failure, primarily caused by neuromuscular diseases, obesity hypoventilation syndrome, chronic obstructive pulmonary and restrictive thoracic diseases. Studies on long-term outcome on health-related quality of life and factors influencing it are lacking...
October 6, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28981157/effects-of-melatonin-on-fatty-liver-disease-the-role-of-nr4a1-dna-pkcs-p53-pathway-mitochondrial-fission-and-mitophagy
#17
Hao Zhou, Wenjuan Du, Ye Li, Chen Shi, Nan Hu, Sai Ma, Weihu Wang, Jun Ren
Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) through poorly defined mechanisms. Melatonin supplementation has been found to protect liver function in diabetes and obesity. Here, we intensively explored the role and mechanism of melatonin in the development of NAFLD. We demonstrated that the onset of diet-induced NAFLD greatly caused NR4A1 upregulation in hepatocytes, leading to the activation of DNA-PKcs and p53. On the one hand, p53 aided Drp1 migration in the mitochondria and consequently drove mitochondrial fission...
October 5, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28974645/noninvasive-ventilation-in-obese-subjects-after-acute-respiratory-failure
#18
Charlotte Bry, Sandrine Jaffré, Béatrice Guyomarc'h, Frédéric Corne, Sylvaine Chollet, Antoine Magnan, François-Xavier Blanc
INTRODUCTION: Noninvasive ventilation (NIV) has been widely used to treat acute respiratory failure in obese patients. Criteria that could help clinicians to decide whether they should continue to use NIV after such an initial episode remain unclear. Our retrospective study aims to analyze characteristics of subjects receiving long-term NIV after an initial hospitalization for acute respiratory failure. METHODS: From January 2011 to December 2012, 77 obese adults were admitted in the ICU of the respiratory disease department in Nantes University Hospital in France...
October 3, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28964798/phenotypic-clusters-predict-outcomes-in-a-longitudinal-interstitial-lung-disease-cohort
#19
Ayodeji Adegunsoye, Justin M Oldham, Jonathan H Chung, Steven M Montner, Cathryn Lee, Leah J Witt, Danielle Stahlbaum, Rene S Bermea, Lena W Chen, Scully Hsu, Aliya N Husain, Imre Noth, Rekha Vij, Mary E Strek, Matthew Churpek
BACKGROUND: The current interstitial lung disease (ILD) classification has overlapping clinical presentations and outcomes. Cluster analysis modeling is a valuable tool in identifying distinct clinical phenotypes in heterogeneous diseases. However, this approach has yet to be implemented in ILD. METHODS: Using cluster analysis, novel ILD phenotypes were identified among subjects from a longitudinal ILD cohort, and outcomes were stratified according to phenotypic clusters compared with subgroups according to current American Thoracic Society/European Respiratory Society ILD classification criteria...
September 28, 2017: Chest
https://www.readbyqxmd.com/read/28958941/jip3-deficiency-protects-mice-from-high-fat-diet-induced-liver-injury
#20
Xiao-Juan Rao, Yu-Min Wu, Yan Wang, Shuang-Wei Shi
Multiple pathways contribute to nonalcoholic fatty liver disease (NAFLD) in response to high fat diets (HFD). A homolog of mammalian JNK-interacting protein 3 (JIP3), also known as JSAP-1, activates different components in various signaling pathways to modulate cellular processes. The purpose of this study was to examine the role of JIP3 in obesity-related pathologies pathway. Wild-type (WT) C57BL/6 and JIP3-knockout (JIP3(-/-)) mice were randomized to chow or HFD. HFD-fed WT mice increased hepatic JIP3 expression...
September 25, 2017: Biochemical and Biophysical Research Communications
keyword
keyword
99822
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"