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Diabetes polyphenols

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https://www.readbyqxmd.com/read/29161661/chlorogenic-acid-prevents-diabetic-nephropathy-by-inhibiting-oxidative-stress-and-inflammation-through-modulation-of-the-nrf2-ho-1-and-nf-%C3%A4-b-pathways
#1
Liping Bao, Jushuang Li, Dongqing Zha, Lian Zhang, Ping Gao, Tao Yao, Xiaoyan Wu
Oxidative and inflammatory damage have been suggested to play important roles in the pathogenesis of diabetic nephropathy (DN). Chlorogenic acid (CGA) is one of the most abundant polyphenols and has known immunoprotective, antioxidant and anti-inflammatory properties. In the present study, animal experiments were designed to examine the protective effects of CGA in DN, and cellular experiments were designed to explore the underlying mechanisms. CGA significantly attenuated diabetic renal damage based on histological pathology and molecular biological methods...
November 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29158770/does-the-enterolactone-enl-affect-fatty-acid-transporters-and-lipid-metabolism-in-liver
#2
Krzysztof Drygalski, Klaudia Berk, Tomasz Charytoniuk, Nicoletta Iłowska, Bartłomiej Łukaszuk, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
Background: NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations. Due to its dangerous aftermaths, finding new substances, such as polyphenols and their derivatives, which might reduce liver steatosis is the main target of research into NAFLD treatment. Hence, the aim of the present study was to evaluate the effect(s) of enterolactone (ENL), a metabolite of secoisolariciresinol (SECO), on lipid metabolism together with changes in the expression of fatty acid transporters in fatty liver...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29156154/coconut-phytocompounds-inhibits-polyol-pathway-enzymes-implication-in-prevention-of-microvascular-diabetic-complications
#3
Devi Lekshmi Sheela, Puthiyaveetil Abdulla Nazeem, Arunaksharan Narayanankutty, R Muthangaparambil Shylaja, Sangeetha P Davis, Priyanga James, Ravisankar Valsalan, Thekkekara Devassy Babu, Achuthan C Raghavamenon
Coconut oil (CO), the primary choice of cooking purposes in the south Asian countries, is rich in medium chain saturated fatty acids, especially lauric acid (50-52%). The oil has high medicinal use in Ayurvedic system and known to contain polyphenolic antioxidants. Studies have reported that CO improves insulin sensitivity and shows hypoglycemic effect. However, there is no information regarding its effect on chronic diabetic complications including retinopathy and nephropathy is available. The secondary diabetic complications are mediated by the activation of polyol pathway, where aldose reductase (AR) plays crucial role...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29154192/resveratrol-attenuates-testicular-apoptosis-in-type-1-diabetic-mice-role-of-akt-mediated-nrf2-activation-and-p62-dependent-keap1-degradation
#4
Yuguang Zhao, Wenjing Song, Zhenyu Wang, Zongqiang Wang, Xing Jin, Jiancheng Xu, Ling Bai, Yuying Li, Jiuwei Cui, Lu Cai
Infertility is a common complication in diabetic men, mainly due to the loss of germ cells by apoptotic cell death. However, effective and safe approaches to prevent diabetic induction of testicular apoptosis for diabetic patients have not been available. Resveratrol (RSV), a group of compounds called polyphenols from plants, has been indicated its promising used clinically for cancers and cardiovascular diseases. Therefore, the present study aimed determining whether RSV attenuates type 1 diabetes (T1D)-induced testicular apoptotic cell death in a mouse model...
November 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/29146347/effect-of-tea-products-on-the-in-vitro-enzymatic-digestibility-of-starch
#5
Haihua Zhang, Yulan Jiang, Junxian Pan, Yangjun Lv, Jun Liu, Shikang Zhang, Yuejin Zhu
The importance of postprandial hyperglycemia in the treatment of diabetes has been recognized recently. Tea products, such as tea polyphenols (TP), epigallocatechin gallate (EGCG), matcha, and instant tea, were chosen as constituents of tea-flour food, aimed at regulating the release of glucose from starchy foods in the postprandial period. Six starches were chosen for internal composition analysis and hydrolysis studies in vitro. Corn starch, wheat starch, and lily root flour appeared to have higher resistant starch content, slower digestion profiles, and lower kinetic constants, implying sustained release of glucose in the gastrointestinal tract...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29142432/inhibition-of-glycation-induced-cytotoxicity-protein-glycation-and-activity-of-proteolytic-enzymes-by-extract-from-perovskia-atriplicifolia-roots
#6
Mehran Miroliaei, Akram Aminjafari, Sylwester Ślusarczyk, Izabela Nawrot-Hadzik, Mehdi Rahimmalek, Adam Matkowski
Background: Protein glycation and glycotoxicity belong to the main oxidative-stress related complications in diabetes. Perovskia species are used in Asian folk medicine as antidiabetic herbs. Objective: The aim of this study was to verify the ability of the methanolic extract from Perovskia atriplicifolia Benth. roots to diminish glycation of albumin and to prevent cell damage in vitro. Furthermore, we tested the extract for in vitro antioxidant activity and inhibition of elastase and collagenase...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142425/hypoglycemic-hypolipidemic-and-wound-healing-potential-of-quercetin-in-streptozotocin-induced-diabetic-rats
#7
Mahrukh Ahmad, Mudasir Sultana, Rajinder Raina, Nrip Kishore Pankaj, Pawan Kumar Verma, Shahid Prawez
Background: Among the dietary polyphenolic, quercetin is the most common compound available in vegetables and fruits. The phytochemicals are used to treat diabetic wounds and diabetes, and specifically dietary polyphenols are being extensively studied for their anti-inflammatory and antioxidant abilities. Objective: The objective of the study was to assess the hypoglycemic, hypolipidemic, and wound healing potential of quercetin in streptozotocin (STZ)-induced diabetic Wistar rats...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141575/the-protective-effects-of-extra-virgin-olive-oil-on-immune-mediated-inflammatory-responses
#8
Rosa Casas, Ramon Estruch, Emilio Sacanella
BACKGROUND AND OBJECTIVE: The increasing interest in the Mediterranean diet (MeDiet) hinges on the relevant role it plays in inflammatory diseases. Several clinical, epidemiological and experimental evidences suggest that consumption of the MeDiet reduces the incidence of certain pathologies related to oxidative stress, chronic inflammation and immune system diseases such as cancer, atherosclerosis and cardiovascular disease (CVD). DISCUSSION: These reductions can be partially attributed to extra virgin olive oil (EVOO) consumption which has been described as a key bioactive food because of its high nutritional quality and its particular composition of fatty acids, vitamins and polyphenols...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141574/anti-inflammatory-activity-of-extra-virgin-olive-oil-polyphenols-which-role-in-the-prevention-and-treatment-of-immune-mediated-inflammatory-diseases
#9
Carmela Santangelo, Rosaria Vari, Beatrice Scazzocchio, Patrizia De Sanctis, Claudio Giovannini, Massimo D'Archivio, Roberta Masella
Altered inflammatory response characterizes chronic immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, and psoriasis. Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source of fat in the Mediterranean diet, is associated with a reduced risk of developing chronic degenerative disorders such cardiovascular diseases, type 2 diabetes and cancer. The beneficial effects on health of EVOO have been attributed, besides to the monounsaturated fats content, to the presence of phenolic compounds that have antioxidant, anti-inflammatory and immunomodulatory properties...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141541/ellagic-acid-a-logical-lead-for-drug-development
#10
Abolfazl Shakeri, Mohammad Reza Zirak, Amirhossein Sahebkar
BACKGROUND: Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer. Ellagic acid (EA) is an herbal polyphenol that is structurally a condensed dimer of gallic acid. METHODS: This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29141041/effects-of-a-mixed-berry-beverage-on-cognitive-functions-and-cardiometabolic-risk-markers-a-randomized-cross-over-study-in-healthy-older-adults
#11
Anne Nilsson, Ilkka Salo, Merichel Plaza, Inger Björck
BACKGROUND: Berries and associated bioactive compounds, e.g. polyphenols and dietary fibre (DF), may have beneficial implications with respect to the metabolic syndrome, including also cognitive functions. The aim of this study was to evaluate effects on cognitive functions and cardiometabolic risk markers of 5 wk intervention with a mixture of berries, in healthy humans. METHODS: Forty healthy subjects between 50-70 years old were provided a berry beverage based on a mixture of berries (150g blueberries, 50g blackcurrant, 50g elderberry, 50g lingonberries, 50g strawberry, and 100g tomatoes) or a control beverage, daily during 5 weeks in a randomized crossover design...
2017: PloS One
https://www.readbyqxmd.com/read/29132827/high-performance-thin-layer-chromatographic-methods-in-the-evaluation-of-the-antioxidant-and-anti-hyperglycemic-activity-of-myrmecodia-platytyrea-as-a-promising-opportunity-in-diabetes-treatment
#12
S Agatonovic-Kustrin, D W Morton, A Adam, H H Mizaton, H Zakaria
The steady increase of diabetes is becoming a major burden on health care systems. As diabetic complications arise from oxidative stress, an antioxidant therapy along with anti-diabetic drugs is recommended. Myrmecodia or ant plant is highly valued as a traditional medicine in West Papua. It is used as an alternative treatment for diabetes, as the substances produced by ants can reduce blood sugar levels. The aim of this study was to develop and establish high-performance thin-layer chromatographic (HPTLC)-bioautographic methods to measure the antioxidant and hypoglycemic effects in different extracts from Myrmecodia platytyrea and to compare them with sterol content...
November 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29128800/beneficial-roles-of-honey-polyphenols-against-some-human-degenerative-diseases-a-review
#13
REVIEW
Md Sakib Hossen, Md Yousuf Ali, M H A Jahurul, Mohamed M Abdel-Daim, Siew Hua Gan, Md Ibrahim Khalil
Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties. Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such as cardiovascular diseases (CVD), diabetes, cancer, neurodegenerative diseases, pulmonary diseases, liver diseases and so on. Nevertheless, it is challenging to identify the specific biological mechanism underlying individual polyphenols and to determine how polyphenols impact human health...
July 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29113147/antibacterial-activity-of-polyphenols-structure-activity-relationship-and-influence-of-hyperglycemic-condition
#14
Yixi Xie, Jing Chen, Aiping Xiao, Liangliang Liu
Polyphenols are plant-derived natural products with well-documented health benefits to human beings, such as antibacterial activities. However, the antibacterial activities of polyphenols under hyperglycemic conditions have been rarely studied, which could be relevant to their antibacterial efficacy in disease conditions, such as in diabetic patients. Herein, the antibacterial activities of 38 polyphenols under mimicked hyperglycemic conditions were evaluated. The structure-antibacterial activity relationships of polyphenols were also tested and analyzed...
November 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29113066/polyphenol-rich-dry-common-beans-phaseolus-vulgaris-l-and-their-health-benefits
#15
REVIEW
Kumar Ganesan, Baojun Xu
Polyphenols are plant metabolites with potent anti-oxidant properties, which help to reduce the effects of oxidative stress-induced dreaded diseases. The evidence demonstrated that dietary polyphenols are of emerging increasing scientific interest due to their role in the prevention of degenerative diseases in humans. Possible health beneficial effects of polyphenols are based on the human consumption and their bioavailability. Common beans (Phaseolus vulgaris L.) are a greater source of polyphenolic compounds with numerous health promoting properties...
November 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29110743/rosmarinic-acid-modes-of-action-medicinal-values-and-health-benefits
#16
Mahmoud Alagawany, Mohamed Ezzat Abd El-Hack, Mayada Ragab Farag, Marappan Gopi, Kumaragurubaran Karthik, Yashpal Singh Malik, Kuldeep Dhama
The supplementation of livestock rations with herbs containing bioactive components, such as rosmarinic acid (RA), have shown promising results as a natural feed additive in promoting growth, productive and reproductive performance, feed utilization, fertility, anti-oxidant status and immunologic indices. Furthermore, RA reportedly reduces the risks of various animal diseases and mitigates side effects of chemical and synthetic drugs. RA is a natural polyphenol present in several Lamiaceae herbs like Perilla frutescens, and RA is becoming an integral component of animal nutrition as it counters the effect of reactive oxygen species induced in the body as a consequence of different kinds of stressors...
November 7, 2017: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29105385/punica-granatum-l-fruit-aqueous-extract-suppresses-reactive-oxygen-species-mediated-p53-p65-mir-145-expressions-followed-by-elevated-levels-of-irs-1-in-alloxan-diabetic-rats
#17
Ehsan Gharib, Shideh Montasser Kouhsari, Maryam Izad
OBJECTIVES: Reactive oxygen species (ROS) is an apoptosis inducer in pancreatic β-cells that stimulates p53/p65 mediated microRNA (miR)-145 expression. Punica granatum L. (pomegranate) is an antioxidant fruit that attenuates ROS generation. This study examines the effects of pomegranate fruit aqueous extract (PGE) on the levels of ROS, p53, p65, miR-145, and its target insulin receptor substrate 1 (irs-1) mRNA in Alloxan-diabetic male Wistar rats. MATERIALS AND METHODS: In this experimental study, diabetic rats received different doses of PGE...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29103827/hybrid-drug-combination-anti-diabetic-treatment-of-type-2-diabetic-wistar-rats-with-combination-of-ellagic-acid-and-pioglitazone
#18
Rakesh P Nankar, Mukesh Doble
BACKGROUND: Pioglitazone is an effective drug for the treatment of type 2 diabetes. The drug was suspended from Indian market in June 2013 due to the risk of bladder cancer but was reintroduced in July 2013 because its benefits outweighed the risks. The risks associated with pioglitazone can be minimized if its dose is reduced. HYPOTHESIS: Ellagic acid, a polyphenolic antioxidant, is reported to reduce blood sugar in diabetic rats. The mechanism of anti-diabetic action of ellagic acid is not known...
October 24, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29103418/hypolipidemic-activity-of-tamarix-articulata-vahl-in-diabetic-rats
#19
Morad Hebi, Mohamed Eddouks
OBJECTIVE: Tamarix articulata Vahl. (Tamaricaceae) is a medicinal plant commonly used in Morocco for the treatment of diabetes mellitus and cardiovascular diseases. The objective of this study was to evaluate the hypolipidemic activity of aqueous extract of T. articulata in normal and streptozotocin (STZ)-induced diabetic rats. Phytochemical analysis as well as determination of polyphenol and flavonoid contents in the aqueous extract of T. articulata was performed. METHODS: The effects of oral administration of aqueous extract of T...
November 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29089337/curcumin-and-other-dietary-polyphenols-potential-mechanisms-of-metabolic-actions-and-therapy-for-diabetes-and-obesity
#20
Tianru Jin, Zhuolun Song, Jianping Weng, I George Fantus
Recent controversy regarding the therapeutic potential of curcumin indicate the challenges to research in this field. Here, we highlight the investigations of curcumin and other plant-derived polyphenols that demonstrate their application to metabolic diseases, in particular obesity and diabetes. Thus a number of preclinical and clinical investigations have shown the beneficial effect of curcumin (and other dietary polyphenols) in attenuating body weight gain, improving insulin sensitivity and preventing diabetes development in rodent models and pre-diabetic subjects...
October 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
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