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Diabetes polyphenols

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https://www.readbyqxmd.com/read/28431322/xanthohumol-and-8-prenylnaringenin-ameliorate-diabetic-related-metabolic-dysfunctions-in-mice
#1
Raquel Costa, Ilda Rodrigues, Luísa Guardão, Sílvia Rocha-Rodrigues, Carolina Silva, José Magalhães, Manuel Ferreira-de-Almeida, Rita Negrão, Raquel Soares
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. Thirty C57Bl/6 mice were randomly divided into five groups: standard diet (control), high-fat diet (DM), high-fat diet plus ethanol (DM-Ethanol), high-fat diet plus 10 mg/L XN (DM-XN) and high-fat diet plus 10 mg/L 8PN (DM-8PN) during 20 weeks...
April 6, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28425868/pomegranate-as-a-possible-treatment-in-reducing-risk-of-developing-wound-healing-obesity-neurodegenerative-disorders-and-diabetes-mellitus
#2
Manaf AlMatar, Md Rashedul Islam, Othman Albari, Işıl Var, Fatih Köksal
Four distinguished although overlying stages make up the methodical procedure of wound healing, which are hemostasis, inflammation, proliferation and remodelling. Multiple sclerosis (MS) comprises a persistent inflammatory infection of the central nervous system, and is related to demyelination, neurodegeneration, as well as susceptibility to oxidative pressure. Obesity signifies a swiftly developing danger to the wellbeing of populations in a rising number of nations. Usually called diabetes mellitus (DM) by medical practitioners, diabetes details a collection of metabolic diseases within which the individual has raised blood glucose, either due to an insufficiency of insulin generation, or the lack of suitable response by the body to insulin, or both...
April 19, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28416441/glechoma-hederacea-extracts-attenuate-cholestatic-liver-injury-in-a-bile-duct-ligated-rat-model
#3
Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Su-Lan Liao, Chih-Cheng Wu, Pin-Ho Pan, Su-Tze Chou, Chun-Jung Chen
ETHNOPHARMACOLOGICAL RELEVANCE: In traditional Chinese medicine, Glechoma hederacea is frequently prescribed to patients with cholelithiasis, dropsy, abscess, diabetes, inflammation, and jaundice. Polyphenolic compounds are main bioactive components of Glechoma hederacea. AIM OF THE STUDY: This study was aimed to investigate the hepatoprotective potential of hot water extract of Glechoma hederacea against cholestatic liver injury in rats. MATERIALS AND METHODS: Cholestatic liver injury was produced by ligating common bile ducts in Sprague-Dawley rats...
April 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28414549/do-marine-algal-polyphenols-have-antidiabetic-anti-hyperlipidaemic-or-anti-inflammatory-effects-in-humans-a-systematic-review
#4
Margaret Murray, Aimee L Dordevic, Maxine P Bonham, Lisa Ryan
Cardiovascular disease and type 2 diabetes are leading causes of morbidity and mortality globally. Marine algal polyphenols have potential to reduce the risk of these conditions, however little is known about their impact in humans. This systematic review investigates the antidiabetic, anti-hyperlipidaemic and anti-inflammatory effects of marine polyphenols in humans. Scopus, Medline, PsychInfo, Embase and Cochrane Library databases were searched in November 2016. Eligible studies included 1) human adults, 2) marine polyphenol intervention, 3) blood lipid, glucose, insulin or inflammatory marker outcomes, and 4) were a randomised-controlled trial...
April 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28412986/effects-of-subacute-ingestion-of-chlorogenic-acids-on-sleep-architecture-and-energy-metabolism-through-activity-of-the-autonomic-nervous-system-a-randomised-placebo-controlled-double-blinded-cross-over-trial
#5
Insung Park, Ryuji Ochiai, Hitomi Ogata, Momoko Kayaba, Sayaka Hari, Masanobu Hibi, Yoshihisa Katsuragi, Makoto Satoh, Kumpei Tokuyama
Chlorogenic acids (CGA) are the most abundant polyphenols in coffee. Continuous consumption of CGA reduces body fat and body weight. Since energy metabolism and sleep are controlled by common regulatory factors, consumption of CGA might modulate sleep. Lack of sleep has been identified as a risk factor for obesity, hypertension and type 2 diabetes. The aim of this study was to determine the effects of ingesting CGA over 5 d on energy metabolism and sleep quality in humans. A total of nine healthy subjects (four male and five female) completed a placebo-controlled, double-blinded, cross-over intervention study...
April 17, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28402903/nutritional-anti-inflammatories-in-the-treatment-and-prevention-of-type-2-diabetes-mellitus-and-the-metabolic-syndrome
#6
REVIEW
Lea Merone, Robyn McDermott
AIMS: Obesity-fuelled metabolic syndrome and diabetes is now a global epidemic. There is increasing evidence that these and other chronic conditions have common inflammatory antecedents. There is an interest in nutritionally based anti-inflammatory treatments for type 2 diabetes and metabolic syndrome. The aim of this review is to examine the evidence from a 5-year period; 2011-2016, for nutritionally based anti-inflammatory treatments for the Metabolic Syndrome and Type 2 Diabetes Mellitus...
February 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28399705/biophysical-insight-reveals-tannic-acid-as-amyloid-inducer-and-conformation-transformer-from-amorphous-to-amyloid-aggregates-in-concanavalin-a-cona
#7
Mohsin Vahid Khan, Mohd Ishtikhar, Mohammad Khursheed Siddiqui, Masihuz Zaman, Tajalli Ilm Chandel, Nabeela Majid, Mohd Rehan Ajmal, Ali Saber Abdelhameed, Yasser E Shahein, Rizwan Hasan Khan
The aggregation phenomenon (amyloid and amorphous) is associated with several pathological complications in human, such as Alzheimer's, Parkinson's, Huntington, Cataract diseases and Diabetes mellitus type 2. In the present study we are offering evidence and breaking the general belief with regard to the polyphenols action as protein aggregate inhibitors. Herein we confirm that tannic acid (TA) is not only an amyloid inducer, but also it switches one type of conformation, ultimately morphology, into another...
April 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28393690/hepatic-amp-kinase-as-a-potential-target-for-treating-nonalcoholic-fatty-liver-disease-evidence-from-studies-of-natural-products
#8
Gang Xu, Kaixun Huang, Jun Zhou
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, is the leading cause of cryptogenic cirrhosis and has consistently been implicated in related metabolic disorders, such as dyslipidemia and type 2 diabetes (T2D). However, the pathogenesis of NAFLD remains to be elucidated, and no established therapeutic regimens for treating NAFLD exist. Adenosine monophosphate (AMP)-activated protein kinase (AMPK), the main cellular energy sensor, has been implicated as a key regulator of hepatic lipid and glucose metabolism...
April 4, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28393248/epigallocatechin-3-gallate-ameliorates-insulin-resistance-in-hepatocytes
#9
Shan-Bo Ma, Rui Zhang, Shan Miao, Bin Gao, Yang Lu, Sen Hui, Long Li, Xiao-Peng Shi, Ai-Dong Wen
Hyperglycemia is a typical pathogenic factor in a series of complications among patients with type II diabetes. Epigallocatechin-3-gallate (EGCG) is the major polyphenol extracted from green tea and is reported to be an antioxidant. The aim of the present study was to examine the effect of EGCG on insulin resistance in human HepG2 cells pretreated with high concentrations of glucose. The protein kinase B (AKT)/glycogen synthase kinase (GSK) pathways were analyzed using western blot analysis in HepG2 cells and primary mouse hepatocytes treated with high glucose and/or EGCG...
April 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28391515/the-potential-effects-of-chlorogenic-acid-the-main-phenolic-components-in-coffee-on-health-a-comprehensive-review-of-the-literature
#10
REVIEW
Narges Tajik, Mahboubeh Tajik, Isabelle Mack, Paul Enck
Chlorogenic acid (CGA), an important biologically active dietary polyphenol, is produced by certain plant species and is a major component of coffee. Reduction in the risk of a variety of diseases following CGA consumption has been mentioned in recent basic and clinical research studies. This systematic review discusses in vivo animal and human studies of the physiological and biochemical effects of chlorogenic acids (CGAs) on biomarkers of chronic disease. We searched PubMed, Embase, Amed and Scopus using the following search terms: ("chlorogenic acid" OR "green coffee bean extract") AND (human OR animal) (last performed on April 1st, 2015) for relevant literature on the in vivo effects of CGAs in animal and human models, including clinical trials on cardiovascular, metabolic, cancerogenic, neurological and other functions...
April 8, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28366989/black-soybean-seed-coat-polyphenols-prevent-aaph-induced-oxidative-dna-damage-in-hepg2-cells
#11
Yasukiyo Yoshioka, Xiu Li, Tianshun Zhang, Takakazu Mitani, Michiko Yasuda, Fumio Nanba, Toshiya Toda, Yoko Yamashita, Hitoshi Ashida
Black soybean seed coat extract (BE), which contains abundant polyphenols such as procyanidins, cyanidin 3-glucoside, (+)-catechin, and (-)-epicatechin, has been reported on health beneficial functions such as antioxidant activity, anti-inflammatory, anti-obesity, and anti-diabetic activities. In this study, we investigated that prevention of BE and its polyphenols on 2,2'-azobis(2-methylpropionamide) dihydrochloride (AAPH)-induced oxidative DNA damage, and found that these polyphenols inhibited AAPH-induced formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker for oxidative DNA damage in HepG2 cells...
March 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28358620/daily-coffee-intake-inhibits-pancreatic-beta-cell-damage-and-nonalcoholic-steatohepatitis-in-a-mouse-model-of-spontaneous-metabolic-syndrome-tsumura-suzuki-obese-diabetic-mice
#12
Syunsuke Watanabe, Tetsuyuki Takahashi, Hirohisa Ogawa, Hisanori Uehara, Takaaki Tsunematsu, Hayato Baba, Yuki Morimoto, Koichi Tsuneyama
BACKGROUND: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, which spontaneously exhibit obesity, diabetes, hyperlipidemia, and NASH with liver nodules...
March 30, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28347309/chemical-composition-and-pharmacological-activities-of-pisum-sativum
#13
Md Nazmul Hasan Zilani, Tamanna Sultana, S M Asabur Rahman, Md Anisuzzman, Md Amirul Islam, Jamil A Shilpi, Md Golam Hossain
BACKGROUND: Consumption of vegetables has been proven to be effective in the prevention of different diseases. Traditionally edible aerial part of Pisum sativum L. subsp. sativum (Fabaceae) is used to treat diabetes, heart diseases and as blood purifier. Present study was aimed to explore the traditional use of aerial parts of P. sativum as a source of antidiabetic agent. In addition, antioxidant activity and chemical composition was carried out. METHODS: Total polyphenol content was spectrophotometrically determined using Folin Chiocalteu's reagent while the flavonoids by aluminum chloride colorimetric assay...
March 27, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28333970/-epicatechin-3-o-%C3%AE-d-allopyranoside-from-davallia-formosana-prevents-diabetes-and-dyslipidemia-in-streptozotocin-induced-diabetic-mice
#14
Cheng-Hsiu Lin, Jin-Bin Wu, Jia-Ying Jian, Chun-Ching Shih
The objective of this study was to evaluate the effects and molecular mechanism of (-)-epicatechin-3-O-β-D-allopyranoside from Davallia formosana (BB) (also known as Gu-Sui-Bu) on type 1 diabetes mellitus and dyslipidemia in streptozotocin (STZ)-induced diabetic mice. This plant was demonstrated to display antioxidant activities and possess polyphenol contents. Diabetic mice were randomly divided into six groups and were given daily oral gavage doses of either BB (at three dosage levels), metformin (Metf) (at 0...
2017: PloS One
https://www.readbyqxmd.com/read/28333074/assessment-of-the-anti-hyperglycaemic-anti-inflammatory-and-antioxidant-activities-of-the-methanol-extract-of-moringa-oleifera-in-diabetes-induced-nephrotoxic-male-wistar-rats
#15
Elizabeth I Omodanisi, Yapo G Aboua, Oluwafemi O Oguntibeju
Diabetes mellitus is an endocrine disease of multiple aetiologies in insulin secretion. A deficiency in insulin results in hyperglycemia with metabolic disturbances of biomolecules. Moringa oleifera (MO) is endemic in the tropics with a variety of ethnomedicinal importance. The leaf of this plant has been reported to possess antioxidant and medicinal properties that may be helpful in the treatment and management of diabetes and its associated complications. Diabetes was induced intraperitoneally in rats by a single dose of streptozotocin (55 mg/kg) and treated with methanolic extract of Moringa oleifera (250 mg/kg b...
March 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28317262/hydroxytyrosol-restores-proper-insulin-signaling-in-an-astrocytic-model-of-alzheimer-s-disease
#16
M Carmen Crespo, Joao Tomé-Carneiro, Cristina Pintado, Alberto Dávalos, Francesco Visioli, Emma Burgos-Ramos
Recent epidemiological evidence demonstrated that diabetes is a risk factor for AD onset and development. Indeed, meta-analyses of longitudinal epidemiologic studies show that diabetes increases AD risk by 50-100%, being insulin resistance (IR) the main binding link between diabetes and AD. Astrocytes are the foremost cerebral macroglial cells and are responsible for converting glucose into lactate and transfer it to neurons that use it as fuel, but Aβ(1-42) impairs insulin signaling and glycogen storage. Recent prospective studies showed that the Mediterranean diet is associated with lower incidence of AD...
March 20, 2017: BioFactors
https://www.readbyqxmd.com/read/28314182/biosynthesis-of-polyphenol-stabilised-nanoparticles-and-assessment-of-anti-diabetic-activity
#17
Yuanyuan Li, Jiaqiang Zhang, Jiangning Gu, Shi Chen
Green synthesis of nanoparticles (NPs) is a major developing field. In this study, we utilised Whitania somnifera leaves as a green source to synthesise platinum (Pt) NPs. Synthesised Pt NPs resulted from controlled synthesis of 12nm spherical particles. The synthesised Pt NPs were subjected to anti-diabetic applications resulting in a significant decrease in plasma glucose levels after injecting the Pt NPs into streptozotocin-induced diabetic rats.
February 24, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28290272/strawberry-and-cranberry-polyphenols-improve-insulin-sensitivity-in-insulin-resistant-non-diabetic-adults-a-parallel-double-blind-controlled-and-randomised-clinical-trial
#18
Martine Paquette, Ana S Medina Larqué, S J Weisnagel, Yves Desjardins, Julie Marois, Geneviève Pilon, Stéphanie Dudonné, André Marette, Hélène Jacques
Plant-derived foods rich in polyphenols are associated with several cardiometabolic health benefits, such as reduced postprandial hyperglycaemia. However, their impact on whole-body insulin sensitivity using the hyperinsulinaemic-euglycaemic clamp technique remains under-studied. We aimed to determine the effects of strawberry and cranberry polyphenols (SCP) on insulin sensitivity, glucose tolerance, insulin secretion, lipid profile, inflammation and oxidative stress markers in free-living insulin-resistant overweight or obese human subjects (n 41) in a parallel, double-blind, controlled and randomised clinical trial...
February 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28285194/islet-encapsulation-with-polyphenol-coatings-decreases-pro-inflammatory-chemokine-synthesis-and-t-cell-trafficking
#19
Dana Pham-Hua, Lindsey E Padgett, Bing Xue, Brian Anderson, Michael Zeiger, Jessie M Barra, Maigen Bethea, Chad S Hunter, Veronika Kozlovskaya, Eugenia Kharlampieva, Hubert M Tse
Type 1 Diabetes (T1D) is a chronic pro-inflammatory autoimmune disease consisting of islet-infiltrating leukocytes involved in pancreatic β-cell lysis. One promising treatment for T1D is islet transplantation; however, clinical application is constrained due to limited islet availability, adverse effects of immunosuppressants, and declining graft survival. Islet encapsulation may provide an immunoprotective barrier to preserve islet function and prevent immune-mediated rejection after transplantation. We previously demonstrated that a novel cytoprotective nanothin multilayer coating for islet encapsulation consisting of tannic acid (TA), an immunomodulatory antioxidant, and poly(N-vinylpyrrolidone) (PVPON), was efficacious in dampening in vitro immune responses involved in transplant rejection and preserving in vitro islet function...
June 2017: Biomaterials
https://www.readbyqxmd.com/read/28274436/red-raspberry-rubus-idaeus-l-intake-decreases-oxidative-stress-in-obese-diabetic-db-db-mice
#20
Giuliana D Noratto, Boon P Chew, Liezl M Atienza
Red raspberry fruit intake was investigated on obese diabetic (db/db) mice for 8weeks. Animals fed isocaloric diets (5.3% freeze-dried raspberry, or control) were assessed for obesity-diabetes-disease risk biomarkers. Results showed that raspberry intake improved antioxidant status and lessened plasma interleukin (IL)-6 (0.3-fold of control, p<0.1); most likely through enhancing glutathione peroxidase (GPx) activity in liver (4.3-fold of control), and in blood (2.1-fold of control). Other disease-risk biomarkers were similar between groups (p>0...
July 15, 2017: Food Chemistry
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