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Diabetes polyphenols

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https://www.readbyqxmd.com/read/28936721/a-novel-resveratrol-derivative-selectively-inhibits-the-proliferation-of-colorectal-cancer-cells-with-kras-mutation
#1
Haruna Okamoto, Taiji Matsukawa, Satoshi Doi, Toshiyuki Tsunoda, Yuuga Sawata, Madoka Naemura, Koichiro Ohnuki, Senji Shirasawa, Yojiro Kotake
Resveratrol is a polyphenolic compound in many edible foods including grapes, peanuts, and berries. Several studies have revealed the beneficial effects of resveratrol against various diseases such as heart disease, diabetes, obesity, neurological disorders, and cancer. A recent study showed that resveratrol inhibits the proliferation of HCT116 human colorectal cancer cells in three-dimensional culture (3DC) via induction of luminal apoptosis in HCT116 cell spheroids. In this study, we showed that a novel compound, caffeic acid-adducted resveratrol, has a stronger inhibitory effect on the growth of HCT116 cell spheroids in 3DC than resveratrol...
September 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28930190/oligonol-a-low-molecular-weight-polyphenol-derived-from-lychee-alleviates-muscle-loss-in-diabetes-by-suppressing-atrogin-1-and-murf1
#2
Hung-Wen Liu, Yen-Ju Chen, Yun-Ching Chang, Sue-Joan Chang
Stimulation of the ubiquitin-proteasome pathway-especially E3 ubiquitin ligases Atrogin-1 and MuRF1-is associated with muscle loss in diabetes. Elevated lipid metabolites impair myogenesis. Oligonol, a low molecular weight polyphenol derived from lychee, exhibited anti-diabetic and anti-obesity properties, suggesting it could be a proper supplement for attenuating muscle loss. Dietary (10 weeks) oligonol supplementation (20 or 200 mg/kg diet) on the skeletal muscle loss was investigated in diabetic db/db mice...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28930173/polyphenols-from-root-tubercles-and-grains-cropped-in-brazil-chemical-and-nutritional-characterization-and-their-effects-on-human-health-and-diseases
#3
REVIEW
Diego Dos Santos Baião, Cyntia Silva de Freitas, Laidson Paes Gomes, Davi da Silva, Anna Carolina N T F Correa, Patricia Ribeiro Pereira, Eduardo Mere Del Aguila, Vania Margaret Flosi Paschoalin
Throughout evolution, plants have developed the ability to produce secondary phenolic metabolites, which are important for their interactions with the environment, reproductive strategies and defense mechanisms. These (poly)phenolic compounds are a heterogeneous group of natural antioxidants found in vegetables, cereals and leguminous that exert beneficial and protective actions on human health, playing roles such as enzymatic reaction inhibitors and cofactors, toxic chemicals scavengers and biochemical reaction substrates, increasing the absorption of essential nutrients and selectively inhibiting deleterious intestinal bacteria...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28911531/biological-actions-and-molecular-effects-of-resveratrol-pterostilbene-and-3-hydroxypterostilbene
#4
REVIEW
Hui-Yun Tsai, Chi-Tang Ho, Yu-Kuo Chen
Stilbenes are a class of polyphenolic compounds, naturally found in a wide variety of dietary sources such as grapes, berries, peanuts, red wine, and some medicinal plants. There are several well-known stilbenes including trans-resveratrol, pterostilbene, and 3'-hydroxypterostilbene. The core chemical structure of stilbene compounds is 1,2-diphenylethylene. Recently, stilbenes have attracted extensive attention and interest due to their wide range of health-beneficial effects such as anti-inflammation, -carcinogenic, -diabetes, and -dyslipidemia activities...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904737/anticataractogenesis-and-antiretinopathy-effects-of-the-novel-protective-agent-containing-the-combined-extract-of-mango-and-vietnamese-coriander-in-stz-diabetic-rats
#5
Jintanaporn Wattanathorn, Paphaphat Thiraphatthanavong, Wipawee Thukham-Mee, Supaporn Muchimapura, Panakaporn Wannanond, Terdthai Tong-Un
The novel protectant against diabetic cataract and diabetic retinopathy is currently required due to the increased prevalence and therapeutic limitation. Based on the advantage of polyphenol on diabetic eye complications, we hypothesized that the combined extract of mango seed Vietnamese coriander (MPO), a polyphenol-rich substance, should possess anticataractogenesis and antiretinopathy in streptozotocin- (STZ-) diabetic rats. MPO at doses of 2, 10, and 50 mg/kg·BW were orally given to STZ-diabetic rats for 10 weeks...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28901409/epigallocatechin%C3%A2-3%C3%A2-gallate-protects-from-high-glucose-induced-podocyte-apoptosis-via-suppressing-endoplasmic-reticulum-stress
#6
Chunhong Xiang, Xiaoyan Xiao, Bei Jiang, Mengkun Zhou, Yidan Zhang, Hui Li, Zhao Hu
Podocytes serve a critical role in the development of many glomerular diseases, including diabetic nephropathy (DN). Epigallocatechin‑3‑gallate (EGCG), a predominant polyphenolic component of green tea, has indicated its therapeutic effects in diabetes. In the present study, mouse podocyte cells were cultured in vitro, cell injury was induced by high glucose, and the protective effect of EGCG on cell proliferation and apoptosis and the underlying mechanisms were investigated. The results demonstrated that high glucose significantly inhibited cell proliferation after 48 and 72 h compared with normal glucose and mannitol treatment...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28895235/infrared-assisted-extraction-and-hplc-analysis-of-prunus-armeniaca-l-pomace-and-detoxified-kernel-and-their-antidiabetic-effects
#7
Karim Raafat, Nada El-Darra, Fatima A Saleh, Hiba N Rajha, Richard G Maroun, Nicolas Louka
INTRODUCTION: Prunus armeniaca L. (P. armeniaca) is one of the medicinal plants with a high safety-profile. OBJECTIVES: The aim of this work was to make an infrared-assisted extraction (IR-AE) of P. armeniaca fruit (pomace) and kernel, and analyse them using reverse phase high-performance liquid chromatography (RP-HPLC) aided method. METHODS: IR-AE is a novel-technique aimed at increasing the extraction-efficiency. The antidiabetic-potentials of the P...
September 12, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28894509/effects-of-polyphenol-intake-on-metabolic-syndrome-current-evidences-from-human-trials
#8
REVIEW
Gemma Chiva-Blanch, Lina Badimon
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors which severely increases the risk of type II diabetes and cardiovascular disease. Several epidemiological studies have observed a negative association between polyphenol intake and MetS rates. Nevertheless, there are relatively small numbers of interventional studies evidencing this association. This review is focused on human interventional trials with polyphenols as polyphenol-rich foods and dietary patterns rich in polyphenols in patients with MetS...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28893620/protective-effects-of-tea-red-wine-and-cocoa-in-diabetes-evidences-from-human-studies
#9
REVIEW
Maria Angeles Martin, Luis Goya, Sonia Ramos
Prevention of diabetes through the diet has recently received an increasing interest, and polyphenolic compounds, such as flavanols, have become important potential chemopreventive natural agents due to their proved benefits on health, with low toxicity and cost. Tea, red wine and cocoa are good sources of flavanols and these highly consumed foods might contribute to prevent diabetes. In this regard, there is increasing evidence for a protective effect of tea, red wine and cocoa consumption against this disorder...
September 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28891383/a-hypothesis-moderate-consumption-of-alcoholic-beverages-contributes-to-lower-prevalence-of-type-2-diabetes-t2dm-due-to-scavenging-of-%C3%AE-dicarbonyls-by-several-classes-of-dietary-phytochemicals
#10
Benjamin S Szwergold
The world is experiencing an epidemic of Type-2-Diabetes (T2DM). This has led to increased morbidity and mortality, explosive growth in heath-care budgets and has an even greater, if indirect, impact on societies and economies of the affected countries. While genetic susceptibility to T2DM is a major determinant of its prevalence, changes in life-styles also play a role. One such change has been a transition from traditional diets characterized by low caloric and high nutrient density to calorie-rich but nutrient-poor Western diets...
September 11, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28888441/effect-of-clarified-brazilian-native-fruit-juices-on-postprandial-glycemia-in-healthy-subjects
#11
Diully Mata Balisteiro, Renata Luise de Araujo, Luciano Ricardo Giacaglia, Maria Inés Genovese
Brazilian native fruits have been shown as excellent sources of polyphenols which are associated with multiple biological activities including inhibition of carbohydrate-hydrolyzing enzymes, α-amylase and α-glucosidase. Postmeal blood glucose elevations and high glycemic index diets can play a major role in the development of type 2 diabetes, therefore alternative approaches to reduce postprandial hyperglycemia are of growing interest in order to reduce diabetes risk. Here we investigated the effect of six Brazilian native clarified fruit juices from Amazon, Savannah and Atlantic Forest biomes on postprandial glycemia after consumption of a carbohydrate meal...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28888089/antidiabetic-potential-of-polyphenolic-rich-fraction-of-tamarindus-indica-seed-coat-in-alloxan-induced-diabetic-rats
#12
Santosh Singh Bhadoriya, Aditya Ganeshpurkar, Ravi Pratap Singh Bhadoriya, Sanjeev Kumar Sahu, Jay Ram Patel
BACKGROUND: Tamarindus is a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the India, Sudan, Nigeria, Bangladesh and entire subcontinent. METHODS: Hydroethanolic seed coat extract of Tamarindus indica (HETI) was assessed for presence of phytoconstituents and selection of optimum dose through acute and sub acute toxicity study...
September 9, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28887918/hepatoprotective-and-hypoglycemic-effects-of-a-tannin-rich-extract-from-ximenia-americana-var-caffra-root
#13
Mansour Sobeh, Mona F Mahmoud, Mohamed A O Abdelfattah, Hesham A El-Beshbishy, Assem M El-Shazly, Michael Wink
BACKGROUND: Liver diseases and diabetes are serious health disorders associated with oxidative stress and ageing. Some plant polyphenols can lower the risk of these diseases. PURPOSE: We investigated the phytochemical profiling of a root extract from Ximenia americana var. caffra using HPLC-PDA-ESI-MS/MS. The antioxidant activities in vitro were investigated. The hepatoprotective activities were studied in rat models with d-galactosamine (d-GaIN)-induced hepatotoxicity and the antidiabetic activities in STZ-diabetic rats were also investigated...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28883903/dietary-polyphenols-mediterranean-diet-prediabetes-and-type-2-diabetes-a-narrative-review-of-the-evidence
#14
REVIEW
Marta Guasch-Ferré, Jordi Merino, Qi Sun, Montse Fitó, Jordi Salas-Salvadó
Dietary polyphenols come mainly from plant-based foods including fruits, vegetables, whole grains, coffee, tea, and nuts. Polyphenols may influence glycemia and type 2 diabetes (T2D) through different mechanisms, such as promoting the uptake of glucose in tissues, and therefore improving insulin sensitivity. This review aims to summarize the evidence from clinical trials and observational prospective studies linking dietary polyphenols to prediabetes and T2D, with a focus on polyphenol-rich foods characteristic of the Mediterranean diet...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28874357/reduced-obesity-diabetes-and-steatosis-upon-cinnamon-and-grape-pomace-are-associated-with-changes-in-gut-microbiota-and-markers-of-gut-barrier
#15
Matthias Van Hul, Lucie Geurts, Hubert Plovier, Céline Druart, Amandine Everard, Marcus Ståhlman, Moez Rhimi, Kleopatra Chira, Pierre-Louis Teissedre, Nathalie M Delzenne, Emmanuelle Maguin, Angèle Guilbot, Amandine Brochot, Philippe Gerard, Fredrik Bäckhed, Patrice D Cani
Increasing evidence suggests that polyphenols have a significant potential in the prevention and treatment of risk factors associated with metabolic syndrome. The objective of this study was to assess the metabolic outcomes of two polyphenol-containing extracts from cinnamon bark (CBE) and grape pomace (GPE) on C57BL/6J mice fed a high-fat diet (HFD) for 8 weeks. Both CBE and GPE were able to decrease fat mass gain and adipose tissue inflammation in mice fed a HFD without reducing food intake. This was associated with reduced liver steatosis and lower plasma non-esterified fatty acids levels...
September 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28873762/the-novel-contributors-of-anti-diabetic-potential-in-mulberry-polyphenols-revealed-by-uhplc-hr-esi-tof-ms-ms
#16
Fuhua Li, Bin Zhang, Gu Chen, Xiong Fu
To explore the comprehensive phenolic profile of mulberry (Morus alba L.) fruit and reveal the novel anti-diabetic constituents, mulberry polyphenols (MP) were fractionated through gradient ethanol elution and subjected to composition and bioactivity analysis. Forty-seven phenolic compounds were identified and quantified through UHPLC-HR-ESI-TOF-MS/MS, including twenty-one newly identified compounds such as delphinidin 3-rutinoside-5-glucoside and cyanidin 3-rutinoside dimer. The antioxidant activity and anti-diabetic potential of fractionated MP were analyzed in vitro and ex vivo with HepG2 and pancreatic β-cell RIN-m5F...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28867799/could-pomegranate-juice-help-in-the-control-of-inflammatory-diseases
#17
REVIEW
Francesca Danesi, Lynnette R Ferguson
Fruits rich in polyphenols, such as pomegranates, have been shown to have health benefits relating to their antioxidant and anti-inflammatory properties. Using data obtained from PubMed and Scopus, this article provides a brief overview of the therapeutic effects of pomegranate on chronic inflammatory diseases (CID) such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), metabolic and cardiovascular disorders, and other inflammatory-associated conditions, with an emphasis on fruit-derived juices...
August 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28864169/molecular-understanding-of-epigallocatechin-gallate-egcg-in-cardiovascular-and-metabolic-diseases
#18
REVIEW
Qian Yi Eng, Punniyakoti Veeraveedu Thanikachalam, Srinivasan Ramamurthy
ETHNOPHARMACOLOGICAL RELEVANCE: The compound epigallocatechin-3-gallate (EGCG), the major polyphenolic compound present in green tea [Camellia sinensis (Theaceae], has shown numerous cardiovascular health promoting activity through modulating various pathways. However, molecular understanding of the cardiovascular protective role of EGCG has not been reported. AIM OF THE REVIEW: This review aims to compile the preclinical and clinical studies that had been done on EGCG to investigate its protective effect on cardiovascular and metabolic diseases in order to provide a systematic guidance for future research...
August 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28862678/rosemary-extract-as-a-potential-anti-hyperglycemic-agent-current-evidence-and-future-perspectives
#19
REVIEW
Madina Naimi, Filip Vlavcheski, Hesham Shamshoum, Evangelia Tsiani
Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin action (termed insulin resistance) combined with impaired insulin secretion. Current methods of prevention and treatments for insulin resistance and T2DM are lacking in number and efficacy and, therefore, there is a need for new preventative measures and targeted therapies. In recent years, chemicals found in plants/herbs have attracted attention for their use as functional foods or nutraceuticals for preventing and treating insulin resistance and T2DM...
September 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28858362/the-acute-effect-of-coffee-on-endothelial-function-and-glucose-metabolism-following-a-glucose-load-in-healthy-human-volunteers
#20
Evan A J Boon, Kevin D Croft, Sujata Shinde, Jonathan M Hodgson, Natalie C Ward
A diet rich in plant polyphenols has been suggested to reduce the incidence of cardiovascular disease and type 2 diabetes mellitus, in part, via improvements in endothelial function. Coffee is a rich source of phenolic compounds including the phenolic acid, chlorogenic acid (CGA). The aim of the study was to investigate the effect of coffee as a whole beverage on endothelial function, blood pressure and blood glucose concentration. Twelve healthy men and women were recruited to a randomised, placebo-controlled, cross-over study, with three treatments tested: (i) 18 g of ground caffeinated coffee containing 300 mg CGA in 200 mL of hot water, (ii) 18 g of decaffeinated coffee containing 287 mg CGA in 200 mL of hot water, and (iii) 200 mL of hot water (control)...
September 20, 2017: Food & Function
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