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Diabetes polyphenols

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https://www.readbyqxmd.com/read/29788873/one-molecule-many-targets-and-numerous-effects-the-pleiotropy-of-curcumin-lies-in-its-chemical-structure
#1
Mahdi Hatamipour, Thomas P Johnston, Amirhossein Sahebkar
Curcumin quite possibly represents one of the most diverse therapeutic agents yet isolated from natural sources. Therapeutic benefits of this extraordinary natural compound have been demonstrated during treatment of a variety of diseases, including cancer, inflammatory processes, immunological disorders, diabetes, and oxidative stress often associated with hyperlipidemia. Due to its unique molecular chemical structure and functional groups, curcumin may bind with and subsequently either inhibit or activate a variety of endogenous biomolecules, including enzymes, receptors, signaling molecules, metals, transcription factors, and even certain proteins located in cell membranes...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29785173/phytochemicals-that-influence-gut-microbiota-as-prophylactics-and-for-the-treatment-of-obesity-and-inflammatory-diseases
#2
REVIEW
Lucrecia Carrera-Quintanar, Rocío I López Roa, Saray Quintero-Fabián, Marina A Sánchez-Sánchez, Barbara Vizmanos, Daniel Ortuño-Sahagún
Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you "feed your microbiota and are fed by it." GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29774337/fermentation-alters-the-bioaccessible-phenolic-compounds-and-increases-the-alpha-glucosidase-inhibitory-effects-of-aronia-juice-in-a-dairy-matrix-following-in-vitro-digestion
#3
Xue Du, Angela D Myracle
The prevalence of diabetes reached 415 million worldwide in 2015. Polyphenol-rich food intake can benefit the glycemic control for individuals with diabetes. Fermentation may increase the bioavailability of polyphenols, which is generally low. Aronia (Aronia melanocarpa) is a polyphenol-rich berry that is native to North America. Proanthocyanins and anthocyanins are the major phenolic compounds in aronia. In this study, aronia kefir was made by fermenting cow's milk with added aronia juice. The changes in bioaccessible polyphenols of aronia kefir during digestion were assessed using an in vitro model...
May 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29770169/dietary-total-antioxidant-capacity-and-dietary-polyphenol-intake-and-prevalence-of-metabolic-syndrome-in-polish-adults-a-nationwide-study
#4
Małgorzata Elżbieta Zujko, Anna Waśkiewicz, Anna Maria Witkowska, Danuta Szcześniewska, Tomasz Zdrojewski, Krystyna Kozakiewicz, Wojciech Drygas
Specific classes and subclasses of polyphenols have been studied for their potential effects on noncommunicable diseases, but studies on association between dietary polyphenol intake (DPI) and dietary total antioxidant capacity (DTAC) and MetS (metabolic syndrome) are scarce. Therefore, the aim of this study was to determine associations between DTAC and DPI and the prevalence of MetS and its components in the Polish adult population. Subjects (5690) were participants of the Polish National Multicentre Health Examination Survey (WOBASZ II study) performed in 2013-2014...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29769013/antidiabetic-effect-of-spearmint-in-streptozotocin-induced-diabetic-rats
#5
Omar Farid, A El Haidani, Mohamed Eddouks
In this work the effect of Mentha spicata (L.) (M. spicata) aerial part aqueous extract (A.P.A.E) at a dose of 20 mg/kg body weight on blood glucose levels has been demonstrated in normal and streptozotocin (STZ) diabetic rats. Additionally, a preliminary phytochemical screening for various bioactive constituents was realized and a dosage of polyphenols and flavonoid has been done. Moreover, the histopathological changes in liver and pancreas have been evaluated both in normal and STZ diabetic rats. The effect of M...
May 16, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29759646/quantification-of-38-dietary-polyphenols-in-plasma-by-differential-isotope-labelling-and-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#6
David Achaintre, Audrey Gicquiau, Liang Li, Sabina Rinaldi, Augustin Scalbert
Polyphenols constitute one of the most complex classes of phytochemicals in the human diet and have been suggested to play a role in the prevention of chronic diseases such as cardiovascular diseases, diabetes and cancers. However, evidence from epidemiological studies is still needed to better understand their role in disease prevention. To do so, robust methods for the accurate measurement of these molecules in large series of samples are needed. We report here the development of a highly-sensitive method based on differential isotope labelling with 13 C- and 12 C-dansyl chloride for the analysis of 38 structurally diverse polyphenols in 50 μL plasma by tandem mass spectrometry with limits of quantification varying between 0...
May 9, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29756477/anti-hyperglycemic-and-anti-inflammatory-activities-of-polyphenolic-rich-extract-of-syzygium-cumini-linn-leaves-in-alloxan-induced-diabetic-rats
#7
Basiru O Ajiboye, Oluwafemi A Ojo, Olivia S Akuboh, Okesola M Abiola, Olajumoke Idowu, Aliyu O Amuzat
In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats were orally administered with 400 mg/kg free phenol, 400 mg/kg bound phenol, and 5 mg/kg metformin, respectively. On the 14th day of oral administration, the animals were sacrificed, anti-hyperglycemic and anti-inflammatory were assessed...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29744225/inhibition-of-intestinal-cellular-glucose-uptake-by-phenolics-extracted-from-whole-wheat-grown-at-different-locations
#8
Maryam Shamloo, Peter J H Jones, Peter K Eck
Whole grain consumption is associated with reduced risk of type 2 diabetes, and the underlying mechanism might be related to the actions of polyphenols. Dietary polyphenols contribute to low glycemic indices through inhibition of intestinal glucose transport proteins. This study has two objectives: (1) to evaluate how the contents of phenolic acids in wheat vary by genetic background and growth condition and (2) to evaluate how these changes translate into physiologic relevance by investigating cellular glucose transporter inhibitions...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29743988/molecular-mechanisms-underlying-curcumin-mediated-therapeutic-effects-in-type-2-diabetes-and-cancer
#9
REVIEW
Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Alicja Wozniak
The growing prevalence of age-related diseases, especially type 2 diabetes mellitus (T2DM) and cancer, has become global health and economic problems. Due to multifactorial nature of both diseases, their pathophysiology is not completely understood so far. Compelling evidence indicates that increased oxidative stress, resulting from an imbalance between production of reactive oxygen species (ROS) and their clearance by antioxidant defense mechanisms, as well as the proinflammatory state contributes to the development and progression of the diseases...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29735097/uhplc-qqq-ms-ms-identification-quantification-of-polyphenols-from-passiflora-subpeltata-fruit-pulp-and-determination-of-nutritional-antioxidant-%C3%AE-amylase-and-%C3%AE-glucosidase-key-enzymes-inhibition-properties
#10
Saravanan Shanmugam, Isla Alcântara Gomes, Marina Denadai, Bruno Dos Santos Lima, Adriano Antunes de Souza Araújo, Narendra Narain, Maria Terezinha Santos Leite Neta, Mairim Russo Serafini, Lucindo José Quintans-Júnior, Parimelazhagan Thangaraj
The diabetic key enzymes inhibition, nutritional, antioxidant activity and bioactive compounds identification of Passiflora subpeltata fruit pulp were investigated. Fifteen polyphenolic compounds including protocatechuic acid, ferulic acid, vanillic acid, epicatechin, p-coumaric acid, cinnamic acid, eriodictyol and quercetin-3-glucoside were identified in the pulp of this species by using UHPLC-QqQ-MS/MS analysis. The total carbohydrates and crude protein contents in fruit pulp were 2.62 mg glucose equivalent/g sample fruit pulp and 8...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29733843/modulation-of-nuclear-factor-%C3%AE%C2%BAb-signaling-and-reduction-of-neural-tube-defects-by-quercetin-3-glucoside-in-embryos-of-diabetic-mice
#11
Chengyu Tan, Fantong Meng, E Albert Reece, Zhiyong Zhao
BACKGROUND: Diabetes mellitus in early pregnancy increases the risk of birth defects in infants. Maternal hyperglycemia stimulates the expression of nitric oxide (NO) synthase 2 (NOS2), which can be regulated by transcription factors of the nuclear factor-κB (NF-κB) family. Increases in reactive nitrogen species (RNS) generate intracellular stress conditions, including nitrosative, oxidative, and endoplasmic reticulum (ER) stresses, and trigger programmed cell death (or apoptosis) in the neural folds, resulting in neural tube defects (NTDs) in the embryo...
May 4, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29732743/regulation-of-autophagy-by-tea-polyphenols-in-diabetic-cardiomyopathy
#12
Hui Zhou, Yan Chen, Shu-Wei Huang, Peng-Fei Hu, Li-Jiang Tang
OBJECTIVE: To investigate the effect of tea polyphenols on cardiac function in rats with diabetic cardiomyopathy, and the mechanism by which tea polyphenols regulate autophagy in diabetic cardiomyopathy. METHODS: Sixty Sprague-Dawley (SD) rats were randomly divided into six groups: a normal control group (NC), an obesity group (OB), a diabetic cardiomyopathy group (DCM), a tea polyphenol group (TP), an obesity tea polyphenol treatment group (OB-TP), and a diabetic cardiomyopathy tea polyphenol treatment group (DCM-TP)...
May 2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29726706/-i-hibiscus-sabdariffa-i-roselle-polyphenol-rich-extract-averts-cardiac-functional-and-structural-abnormalities-in-type-1-diabetic-rats
#13
Nur Liyana Mohammed Yusof, Satirah Zainalabidin, Norsyahida Mohd Fauzi, Siti Balkis Budin
Diabetes mellitus is often associated with cardiac functional and structural alteration, an initial event leading to cardiovascular complications. <i>Hibiscus sabdariffa</i> or roselle has been widely proven as an antioxidant and recently has incited research interest for its potential in treating cardiovascular disease. Therefore, this study aimed to determine the cardioprotective effects of <i>H. sabdariffa </i>(roselle) polyphenol-rich extract (HPE) in type-1 induced diabetic rats...
May 4, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29723857/resveratrol-modulates-apoptosis-and-autophagy-induced-by-high-glucose-and-palmitate-in-cardiac-cells
#14
Kui Xu, Xiu-Fen Liu, Zhi-Qiang Ke, Qing Yao, Shuang Guo, Chao Liu
BACKGROUND/AIMS: Diabetic cardiomyopathy is associated with increased apoptosis and suppressed autophagy in cardiac cells. The polyphenol resveratrol has shown beneficial effects in various cardiovascular diseases. This study investigated if resveratrol protected cardiac cells by modulating apoptosis and autophagy in the context of diabetes. METHODS: H9c2 cardiac myoblast cells were exposed to high glucose combined with palmitate. Autophagy was evaluated by estimating LC3-II/I ratio, P62 protein levels, and LC3 fluorescent puncta...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29710819/carnosol-increases-skeletal-muscle-cell-glucose-uptake-via-ampk-dependent-glut4-glucose-transporter-translocation
#15
Filip Vlavcheski, David Baron, Ioannis A Vlachogiannis, Rebecca E K MacPherson, Evangelia Tsiani
Skeletal muscle is a major insulin-target tissue and plays an important role in glucose homeostasis. Insulin action in muscle activates the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway causing the translocation of intracellularly stored GLUT4 glucose transporters to the plasma membrane and increased glucose uptake. Impaired insulin action in muscle results in insulin resistance and type 2 diabetes mellitus (T2DM). Activation of the energy sensor AMP-activated kinase (AMPK) increases muscle glucose uptake and the use of AMPK activators is viewed as an effective strategy to combat insulin resistance...
April 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29710469/hydroxytyrosol-nicotinate-a-new-multifunctional-hypolipidemic-and-hypoglycemic-agent
#16
Yun-Dong Xie, Zi-Zhang Chen, Na Li, Wen-Fang Lu, Yan-Hong Xu, Yuan-Yuan Lin, Li-Hua Shao, Qiu-Tang Wang, Li-Ying Guo, Yu-Qiong Gao, Guang-De Yang, Yi-Ping Li, Xiao-Li Bian
Hydroxytyrosol (HT) is a natural polyphenol antioxidant that exists in olive oil. In the study of multifunctional hypolipidemic of nicotinic derivatives, we found that hydroxytyrosol nicotinate (HT-N) incorporation of niacin with HT displayed ?-glucosidase inhibitory activities in vitro, such as yeast ?-glucosidase (IC50 ?=?117.72??M) and rat intestinal ?-glucosidases maltase (IC50 ?=?31.86??M) and sucrase (IC50 ?=?22.99??M), and had a good control of postprandial blood glucose (PBG). HT-N shown significantly hypoglycemic action by 16...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29693586/ellagic-acid-alleviates-hepatic-oxidative-stress-and-insulin-resistance-in-diabetic-female-rats
#17
Simran Alexandria Polce, Cameron Burke, Lucas Martins França, Benjamin Kramer, Antonio Marcus de Andrade Paes, Maria Alicia Carrillo-Sepulveda
Non-alcoholic fatty liver disease (NAFLD) affects more than 70% of patients with type 2 diabetes mellitus (T2DM) and has become one of the most common metabolic liver diseases worldwide. To date, treatments specifically targeting NAFLD do not exist. Oxidative stress and insulin resistance have been implicated in the pathogenesis of NAFLD in diabetes. Accordingly, the goal of this present study was to determine whether Ellagic acid (EA), a natural antioxidant polyphenol found in berries and nuts, mitigates hepatic oxidative stress and insulin resistance in T2DM rats, and thus alleviates NAFLD...
April 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29677167/the-role-of-catechins-in-cellular-responses-to-oxidative-stress
#18
REVIEW
Jurga Bernatoniene, Dalia Marija Kopustinskiene
Catechins are polyphenolic compounds&mdash;flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29668036/optimization-of-extraction-of-hypoglycemic-ingredients-from-grape-seeds-and-evaluation-of-%C3%AE-glucosidase-and-%C3%AE-amylase-inhibitory-effects-in-vitro
#19
Fansheng Kong, Yaru Qin, Zhipeng Su, Zhengxiang Ning, Shujuan Yu
Grape seeds full with oil and also rich in hypoglycemic ingredients. This study is to improve the comprehensive utilization of grape seeds and the quality of grape seeds oil. Extract water soluble active substances before extracting oil from grape seeds, which show the grape seeds in water soluble extracts containing TP, TC, PC contents, respectively, are 171.1 ± 1.1, 658.8 ± 0.2, 482.3 ± 0.2 (mg GSAE/g). Also we found GSAE samples containing catechin and epicatechin were 44.12 ± 0.21 mg/mL, 111.23 ± 1...
April 18, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29652940/functionality-of-cow-milk-naturally-enriched-with-polyunsaturated-fatty-acids-and-polyphenols-in-diets-for-diabetic-rats
#20
Emerson H Yoshimura, Nadine W Santos, Erica Machado, Bruna C Agustinho, Lucelia M Pereira, Sílvia C de Aguiar, Anacharis B Sá-Nakanishi, Cecília E Mareze-da-Costa, Lucia M Zeoula
The increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturated fatty acids (PUFA) and polyphenols in rats with streptozotocin-induced diabetes. Forty male 28-day-old Wistar rats were distributed in four experimental treatments of diabetic animals (streptozotocin induction) and a normal group (non-induced)...
2018: PloS One
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