keyword
https://read.qxmd.com/read/38398799/effect-of-polyphenol-supplementation-on-memory-functioning-in-overweight-and-obese-adults-a-systematic-review-and-meta-analysis
#21
REVIEW
Sara Farag, Catherine Tsang, Emad A S Al-Dujaili, Philip N Murphy
Negative health consequences of obesity include impaired neuronal functioning and cell death, thus bringing the risk of impaired cognitive functioning. Antioxidant properties of polyphenols offer a possible intervention for overweight people, but evidence for their effectiveness in supporting cognitive functioning is mixed. This review examined evidence from randomized controlled trials concerning the effect of polyphenols on tasks requiring either immediate or delayed retrieval of learned information, respectively, thus controlling for differences in cognitive processes and related neural substrates supporting respective task demands...
February 6, 2024: Nutrients
https://read.qxmd.com/read/38398772/molecular-assessment-of-methylglyoxal-induced-toxicity-and-therapeutic-approaches-in-various-diseases-exploring-the-interplay-with-the-glyoxalase-system
#22
REVIEW
Muhanad Alhujaily
This comprehensive exploration delves into the intricate interplay of methylglyoxal (MG) and glyoxalase 1 (GLO I) in various physiological and pathological contexts. The linchpin of the narrative revolves around the role of these small molecules in age-related issues, diabetes, obesity, cardiovascular diseases, and neurodegenerative disorders. Methylglyoxal, a reactive dicarbonyl metabolite, takes center stage, becoming a principal player in the development of AGEs and contributing to cell and tissue dysfunction...
February 17, 2024: Life
https://read.qxmd.com/read/38398503/the-perfect-cup-coffee-derived-polyphenols-and-their-roles-in-mitigating-factors-affecting-type-2-diabetes-pathogenesis
#23
REVIEW
Brooke Chapple, Seth Woodfin, William Moore
Type 2 diabetes (T2D) is a growing health concern with an estimated 462 million people having been diagnosed worldwide. T2D is characterized by chronically elevated blood glucose and insulin resistance, which culminate in a diminished function of the β-cell mass in its later stages. This can be perpetuated by and result in inflammation, excess reactive oxygen species production, obesity, and the dysregulation of multiple cellular pathways. Many naturally occurring small molecules have been investigated in terms of their roles in modulating glucose homeostasis and β-cell function...
February 6, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38397458/polyphenols-role-in-modulating-immune-function-and-obesity
#24
REVIEW
Md Abdullah Al Mamun, Ahmed Rakib, Mousumi Mandal, Santosh Kumar, Bhupesh Singla, Udai P Singh
Polyphenols, long-used components of medicinal plants, have drawn great interest in recent years as potential therapeutic agents because of their safety, efficacy, and wide range of biological effects. Approximately 75% of the world's population still use plant-based medicinal compounds, indicating the ongoing significance of phytochemicals for human health. This study emphasizes the growing body of research investigating the anti-adipogenic and anti-obesity functions of polyphenols. The functions of polyphenols, including phenylpropanoids, flavonoids, terpenoids, alkaloids, glycosides, and phenolic acids, are distinct due to changes in chemical diversity and structural characteristics...
February 14, 2024: Biomolecules
https://read.qxmd.com/read/38396635/sirtuins-as-players-in-the-signal-transduction-of-citrus-flavonoids
#25
REVIEW
Giovanni Enrico Lombardo, Caterina Russo, Alessandro Maugeri, Michele Navarra
Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+ )-dependent class III histone deacetylases, which come into play in the regulation of epigenetic processes through the deacetylation of histones and other substrates. The human genome encodes for seven homologs (SIRT1-7), which are localized into the nucleus, cytoplasm, and mitochondria, with different enzymatic activities and regulatory mechanisms. Indeed, SIRTs are involved in different physio-pathological processes responsible for the onset of several human illnesses, such as cardiovascular and neurodegenerative diseases, obesity and diabetes, age-related disorders, and cancer...
February 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38391003/effect-of-proanthocyanidins-on-blood-lipids-a-systematic-review-and-meta-analysis
#26
REVIEW
Peng Wang, Xue Lian Liu, Zong Zhe Jiang, Yang Long, Chen Lin Gao, Wei Huang, Xiao Zhen Tan, Xiu Mei Ma, Yong Xu
Proanthocyanidins (PCs) are natural antioxidant polyphenols and their effect on the regulation of blood lipids is still controversial. This study was conducted to evaluate the effect of PCs on lipid metabolism. We searched PubMed, Embase, Web of Science, Chinese biomedical literature service system, China National Knowledge Internet, and Wanfang Data with no time restriction until March 18, 2022, using various forms of "proanthocyanidins" and "blood lipid" search terms. Randomized controlled trials investigating the relationship between PCs and lipid metabolism were included...
February 23, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38378922/physiological-functions-of-poorly-absorbed-polyphenols-via-the-glucagon-like-peptide-1
#27
JOURNAL ARTICLE
Yoko Yamashita
Polyphenols are compounds of plant origin with several documented bioactivities related to health promotion. Some polyphenols are hard to be absorbed into the body due to their structural characteristics. This review focuses on the health beneficial effects of polyphenols mediated by intestinal hormones, particularly related to the systemic functions through the secretion of glucagon-like peptide 1 (GLP-1), an enteric hormone that stimulates postprandial insulin secretion. GLP-1 is secreted from L cells in the distal small intestine...
February 20, 2024: Bioscience, Biotechnology, and Biochemistry
https://read.qxmd.com/read/38370057/the-effects-of-pomegranate-consumption-on-obesity-indices-in-adults-a-systematic-review-and-meta-analysis
#28
REVIEW
Hossein Bahari, Sanaz Pourreza, Kian Goudarzi, Seyedeh Nooshan Mirmohammadali, Omid Asbaghi, Kosar Sadat Hosseini Kolbadi, Moslem Naderian, Ali Hosseini
Evidence supports the potential application of polyphenols as agents against obesity. Pomegranate is one of the fruits that possess a high content of polyphenols. This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of pomegranate consumption on obesity indices, including body mass index (BMI), body weight, waist circumference (WC), fat mass (FM), body fat percentage (BFP), and fat-free mass (FFM) in adults. Relevant RCTs were obtained by searching databases, including PubMed, SCOPUS, and Web of Science, up to May 2023...
February 2024: Food Science & Nutrition
https://read.qxmd.com/read/38358042/phenolic-composition-and-bioactivities-of-sea-buckthorn-hippophae-rhamnoids-l-fruit-and-seeds-an-unconventional-source-of-natural-antioxidants-in-north-america
#29
JOURNAL ARTICLE
Renan Danielski, Fereidoon Shahidi
BACKGROUND: Sea buckthorn (Hippophae rhamnoids L.) was introduced in Canada in the early 2000s. This plant bears fruits with high commercial value in other countries due to its premium oil. Nevertheless, sea buckthorn berries are also a rich source of bioactives with nutraceutical potential, especially the variety grown in Newfoundland (Canada), which has not previously been characterized. As such, this study evaluated the composition of polyphenols in sea buckthorn pomace and seeds, as well as their prospective health-promoting effects...
February 15, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38354975/anthocyanins-potential-phytochemical-candidates-for-the-amelioration-of-non-alcoholic-fatty-liver-disease
#30
REVIEW
Bitasta Mandal, Rakesh Das, Sandip Mondal
Nonalcoholic fatty liver disease (NAFLD) is described by too much hepatic fat deposition causing steatosis, which further develops into nonalcoholic steatohepatitis (NASH), defined by necroinflammation and fibrosis, progressing further to hepatic cirrhosis, hepatocellular carcinoma, and liver failure. NAFLD is linked to different aspects of the metabolic syndrome like obesity, insulin resistance, hypertension, and dyslipidemia, and its pathogenesis involves several elements including diet, obesity, disruption of lipid homeostasis, and a high buildup of triglycerides and other lipids in liver cells...
February 13, 2024: Annales Pharmaceutiques Françaises
https://read.qxmd.com/read/38346281/a-structure-activity-relationship-study-of-amino-acid-derivatives-of-pterostilbene-analogues-toward-human-breast-cancer
#31
JOURNAL ARTICLE
Fabiana Cordella, Nicola Dragone, Rosarita D'Orsi, Concetta Saponaro, Daniele Vergara, Marco Lessi, Gaetano Angelici
Pterostilbene is the dimethylated analogue of Resveratrol, a compound with well-known biological activities, such as antioxidant, chemopreventive, anti-diabetic, anti-obesity, and cardioprotective. Despite many studies on the general effect of such polyphenolic molecules and their derivatives, a deep comprehension of their action and systematic structure-activity relationship studies are still rare. Herein, three different analogues of functionalizable Pterostilbene were efficiently synthesized and derivatized with a selected library of antioxidant amino acids, allowing for a highly diversified exploration of the chemical space...
February 12, 2024: ChemMedChem
https://read.qxmd.com/read/38343059/the-recommendation-of-the-mediterranean-styled-japanese-diet-for-healthy-longevity
#32
JOURNAL ARTICLE
Kazuki Santa, Yoshio Kumazawa, Kenji Watanabe, Isao Nagaoka
BACKGROUND: The Mediterranean diet, listed as the intangible cultural heritage of humanity by UNESCO, is known as healthy and consumed worldwide. The Japanese diet is also listed and considered healthy. This narrative review compares the Mediterranean diet with its Japanese counterpart. DISCUSSION: Research has reported that people in Mediterranean regions, such as Italy and Greece, have one-third of the mortality ratio from cardiovascular diseases compared to people in the United States and Northern Europe because of the difference in eating habits...
February 9, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/38339081/metabolic-insights-into-caffeine-s-anti-adipogenic-effects-an-exploration-through-intestinal-microbiota-modulation-in-obesity
#33
REVIEW
Isabela Monique Fortunato, Quélita Cristina Pereira, Fabricio de Sousa Oliveira, Marisa Claudia Alvarez, Tanila Wood Dos Santos, Marcelo Lima Ribeiro
Obesity, a chronic condition marked by the excessive accumulation of adipose tissue, not only affects individual well-being but also significantly inflates healthcare costs. The physiological excess of fat manifests as triglyceride (TG) deposition within adipose tissue, with white adipose tissue (WAT) expansion via adipocyte hyperplasia being a key adipogenesis mechanism. As efforts intensify to address this global health crisis, understanding the complex interplay of contributing factors becomes critical for effective public health interventions and improved patient outcomes...
February 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38329279/urolithin-a-production-drives-the-effects-of-pomegranate-on-the-gut-microbial-metabolism-of-bile-acids-and-cholesterol-in-mild-dyslipidaemic-overweight-and-obese-individuals
#34
JOURNAL ARTICLE
Adrián Cortés-Martín, Carlos E Iglesias-Aguirre, Alicia Marín, María Romo-Vaquero, Fernando Vallejo, Juan Carlos Espín, María Victoria Selma
The metabolism of (poly)phenols and some host metabolites, including bile acids (BAs) and cholesterol, varies among individuals depending on their gut microbiota. The gut microbial metabolism of ellagitannins (ETs) and ellagic acid (EA) produces urolithins (Uros), yielding three metabotypes with quantitative and qualitative differences based on dissimilar Uro-producing profiles (UM-A, UM-B, and UM-0, i.e. , non-producers). Previous animal studies demonstrated that polyphenols impact BAs and cholesterol microbial metabolism, but data on their effects in humans and data regarding the inter-individual variability of these metabolic conversions are scant...
February 8, 2024: Food & Function
https://read.qxmd.com/read/38324260/effect-of-resveratrol-on-insulin-action-in-primary-myotubes-from-lean-and-individuals-with-severe-obesity
#35
JOURNAL ARTICLE
Sanghee Park, Filip Jevtovic, Polina M Krassovskaia, Alec B Chaves, Donghai Zheng, Jonas T Treebak, Joseph A Houmard
Background. Resveratrol (RSV), a natural polyphenol compound contained in numerous plants, has been proposed as a treatment for obesity-related disease processes such as insulin resistance. However, in humans there are conflicting results concerning the efficacy of RSV in improving insulin action; the purpose of the present study was to determine if obesity status (lean, severely obese) affects the response to RSV in human skeletal muscle. Methods. Primary skeletal muscle cells were derived from biopsies obtained from age-matched lean and insulin-resistant women with severe obesity and incubated with RSV (1µM) for 24-hours...
February 7, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38317864/a-polyphenol-rich-plant-extract-prevents-hypercholesterolemia-and-modulates-gut-microbiota-in-western-diet-fed-mice
#36
JOURNAL ARTICLE
Cédric Langhi, Marie Vallier, Auriane Bron, Yolanda F Otero, Maheva Maura, Florian Le Joubioux, Niek Blomberg, Martin Giera, Bruno Guigas, Thierry Maugard, Benoit Chassaing, Sébastien Peltier, Stéphanie Blanquet-Diot, Jean-Marie Bard, Pascal Sirvent
INTRODUCTION: Totum-070 is a combination of five plant extracts enriched in polyphenols to target hypercholesterolemia, one of the main risk factors for cardiovascular diseases. The aim of this study was to investigate the effects of Totum-070 on cholesterol levels in an animal model of diet-induced hypercholesterolemia. METHODS: C57BL/6JOlaHsd male mice were fed a Western diet and received Totum-070, or not, by daily gavage (1g/kg and 3g/kg body weight) for 6 weeks...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38317482/benefits-of-monascus-anka-solid-state-fermentation-for-quinoa-polyphenol-bioaccessibility-and-the-anti-obesity-effect-linked-with-gut-microbiota
#37
JOURNAL ARTICLE
Kai Huang, Guoqiang Chu, Pei Yang, Yongyong Liu, Yu Zhang, Xiao Guan, Sen Li, Hongdong Song, Ying Zhang
In our previous study, a polyphenol-utilization targeted quinoa product was developed via solid-state fermentation with Monascus anka . In this study, we investigated the polyphenol-related novel functions of the fermented product further. Compared with unfermented quinoa, M. anka fermented quinoa alleviated the trapping effect of the macromolecules, especially in the colonic fermentation stage, resulting in enhanced polyphenol bioaccessibility. Lachnoclostridium , Megasphaera , Megamonas , Dialister , and Phascolarctobacterium might contribute to polyphenol liberation and metabolism in fermented quinoa...
February 6, 2024: Food & Function
https://read.qxmd.com/read/38312542/effects-of-citrus-depressa-hayata-juice-on-high-fat-diet-induced-obesity-in-hbv-transgenic-mice
#38
JOURNAL ARTICLE
Pei-Yi Chu, Chang-Lu Hsu, Yen-An Lin, Yi-Cheng Pan, Yun-Hao Dai, Ying-Chun Yu, Juan-Cheng Yang, Wen-Lung Ma, Yi-Jinn Lillian Chen, Chia-Lin Lee, Yang-Chang Wu
The present study investigated the potential anti-obesity properties of Citrus depressa Hayata (CDH) juice in HBV transgenic mice, as well as the impact of fermentation on the effectiveness of the juice. The results revealed that fermentation increased the levels of polyphenols and hesperidin in CDH juice. The animal study demonstrated that both juices were effective in mitigating the weight gain induced by a high-fat diet by correcting metabolic parameter imbalances, reducing hepatic lipid accumulation, and reversing hepatic immune suppression...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38310782/inhibition-of-pancreatic-lipase-by-coffee-leaves-derived-polyphenols-a-mechanistic-study
#39
JOURNAL ARTICLE
Qingwei Cao, Suhuan Mei, Arshad Mehmood, Yu Sun, Xiumin Chen
The suppression of pancreatic lipase has been employed to mitigate obesity. This study explored the mechanism of coffee leaf extracts to inhibit pancreatic lipase. The ethyl acetate fraction derived from coffee leaves (EAC) exhibited the highest inhibitory capacity with a half-maximal inhibitory concentration (IC50 ) of 0.469 mg/mL and an inhibitor constant (Ki ) of 0.185 mg/mL. This fraction was enriched with 3,5-dicaffeoylquinic acid (3,5-diCQA, 146.50 mg/g), epicatechin (87.51 mg/g), and isoquercetin (48...
January 24, 2024: Food Chemistry
https://read.qxmd.com/read/38310647/chaenomeles-sinensis-thouin-koehne-fruit-polyphenols-alleviate-high-fat-diet-induced-obesity-and-liver-steatosis-by-improving-lipid-metabolism-in-mice
#40
JOURNAL ARTICLE
Haizhao Song, Hong Li, Jing Lu, Minfang Chen, Yubo Cao, Qiang Chu
Chaenomeles sinensis (Thouin) Koehne fruit is a rich source of medicinally and nutritionally important natural phytochemicals that benefit human health. Based on the information provided, we hypothesized that Chaenomeles sinensis (Thouin) Koehne fruit polyphenols (CSFP) possessed in vivo protective effect of on high-fat diet (HFD)-induced obesity and hepatic steatosis. Specific pathogen-free male C57BL/6J mice were randomly divided into 3 groups and fed with a low-fat diet, HFD, or HFD supplemented with CSFP by intragastric administration for 14 weeks...
January 20, 2024: Nutrition Research
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