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Obesity polyphenols

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https://www.readbyqxmd.com/read/28930190/oligonol-a-low-molecular-weight-polyphenol-derived-from-lychee-alleviates-muscle-loss-in-diabetes-by-suppressing-atrogin-1-and-murf1
#1
Hung-Wen Liu, Yen-Ju Chen, Yun-Ching Chang, Sue-Joan Chang
Stimulation of the ubiquitin-proteasome pathway-especially E3 ubiquitin ligases Atrogin-1 and MuRF1-is associated with muscle loss in diabetes. Elevated lipid metabolites impair myogenesis. Oligonol, a low molecular weight polyphenol derived from lychee, exhibited anti-diabetic and anti-obesity properties, suggesting it could be a proper supplement for attenuating muscle loss. Dietary (10 weeks) oligonol supplementation (20 or 200 mg/kg diet) on the skeletal muscle loss was investigated in diabetic db/db mice...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28928462/total-and-specific-dietary-polyphenol-intakes-and-6-year-anthropometric-changes-in-a-middle-aged-general-population-cohort
#2
S Adriouch, E Kesse-Guyot, T Feuillet, M Touvier, V Olié, V Andreeva, S Hercberg, P Galan, L Fezeu
BACKGROUND: Dietary polyphenols are suggested anti-obesogenic agents. Prospective evidence in general populations of an association between polyphenol intakes and anthropometry is lacking. OBJECTIVE: To assess the associations between dietary polyphenol intakes and changes in body mass index (BMI) and waist circumference (WC) over a 6-year period. METHODS: Individual intakes of 264 different polyphenols (mg/day) were estimated using the Phenol-Explorer database and the mean of 6-17 24-h dietary records collected in 1994-1996...
September 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28904735/corrigendum-to-immune-profile-of-obese-people-and-in-vitro-effects-of-red-grape-polyphenols-on-peripheral-blood-mononuclear-cells
#3
Thea Magrone, Emilio Jirillo, Anna Spagnoletta, Manrico Magrone, Matteo Antonio Russo, Sergio Fontana, Flavia Laforgia, Ilaria Donvito, Angelo Campanella, Franco Silvestris, Giovanni De Pergola
[This corrects the article DOI: 10.1155/2017/9210862.].
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28874357/reduced-obesity-diabetes-and-steatosis-upon-cinnamon-and-grape-pomace-are-associated-with-changes-in-gut-microbiota-and-markers-of-gut-barrier
#4
Matthias Van Hul, Lucie Geurts, Hubert Plovier, Céline Druart, Amandine Everard, Marcus Ståhlman, Moez Rhimi, Kleopatra Chira, Pierre-Louis Teissedre, Nathalie M Delzenne, Emmanuelle Maguin, Angèle Guilbot, Amandine Brochot, Philippe Gerard, Fredrik Bäckhed, Patrice D Cani
Increasing evidence suggests that polyphenols have a significant potential in the prevention and treatment of risk factors associated with metabolic syndrome. The objective of this study was to assess the metabolic outcomes of two polyphenol-containing extracts from cinnamon bark (CBE) and grape pomace (GPE) on C57BL/6J mice fed a high-fat diet (HFD) for 8 weeks. Both CBE and GPE were able to decrease fat mass gain and adipose tissue inflammation in mice fed a HFD without reducing food intake. This was associated with reduced liver steatosis and lower plasma non-esterified fatty acids levels...
September 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28870713/dietary-pomegranate-extract-and-inulin-affect-gut-microbiome-differentially-in-mice-fed-an-obesogenic-diet
#5
Song Zhang, Jieping Yang, Susanne M Henning, Rupo Lee, Mark Hsu, Emma Grojean, Rita Pisegna, Austin Ly, David Heber, Zhaoping Li
Growing evidence suggests that dysbiosis of gut microbiota is associated with pathogenesis of a variety of human diseases. Using dietary intervention to shape the composition and metabolism of the gut microbiota is increasingly recognized. In the present study, we investigated the effects of polysaccharide inulin and polyphenol-rich pomegranate extract (PomX) alone or in combination on the cecal microbiota composition and function in a diet induced obesity mouse model. Male C57BL/6 mice were randomly divided into four experimental groups and consumed either high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose, 17% energy from protein)] diet, HF/HS diet supplemented with PomX (0...
September 13, 2017: Anaerobe
https://www.readbyqxmd.com/read/28867080/dietary-nutritional-profile-and-phenolic-compounds-consumption-in-school-children-of-highlands-of-argentine-northwest
#6
M C Rossi, M N Bassett, N C Sammán
The objective of this work was to assess dietary patterns and consumption of phenolic compounds from fruits and vegetables byschoolchildren of high altitude regions from northwest of Argentina. A nutritional survey including food-frequency consumption, 24-h dietary recall and anthropometric measurements was applied to 241 children from 6 to 12years old. The amounts of the different classes of phenolic compounds were established from Food Composition Tables available in phenol-explorer website. Statistics analyses were performed using IBM SPSS 20...
January 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28863365/a-polyphenolic-extract-from-green-tea-leaves-activates-fat-browning-in-high-fat-diet-induced-obese-mice
#7
Audrey M Neyrinck, Laure B Bindels, Lucie Geurts, Matthias Van Hul, Patrice D Cani, Nathalie M Delzenne
Fat browning has emerged as an attractive target for the treatment of obesity and related metabolic disorders. Its activation leads to increased energy expenditure and reduced adiposity, thus contributing to a better energy homeostasis. Green tea extracts (GTEs) were shown to attenuate obesity and low-grade inflammation and to induce the lipolytic pathway in the white adipose tissue (WAT) of mice fed a high-fat diet. The aim of the present study was to determine whether the antiobesity effect of an extract from green tea leaves was associated with the activation of browning in the WAT and/or the inhibition of whitening in the brown adipose tissue (BAT) in HF-diet induced obese mice...
July 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28846633/strawberries-improve-pain-and-inflammation-in-obese-adults-with-radiographic-evidence-of-knee-osteoarthritis
#8
Jace Schell, R Hal Scofield, James R Barrett, Biji T Kurien, Nancy Betts, Timothy J Lyons, Yan Daniel Zhao, Arpita Basu
Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee...
August 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28840618/the-beneficial-effect-of-anthocyanidin-rich-vitis-vinifera-l-grape-skin-extract-on-metabolic-changes-induced-by-high-fat-diet-in-mice-involves-antiinflammatory-and-antioxidant-actions
#9
Gisele França da Costa, Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28825642/multi-targeted-molecular-effects-of-hibiscus-sabdariffa-polyphenols-an-opportunity-for-a-global-approach-to-obesity
#10
REVIEW
María Herranz-López, Mariló Olivares-Vicente, José Antonio Encinar, Enrique Barrajón-Catalán, Antonio Segura-Carretero, Jorge Joven, Vicente Micol
Improper diet can alter gene expression by breaking the energy balance equation and changing metabolic and oxidative stress biomarkers, which can result in the development of obesity-related metabolic disorders. The pleiotropic effects of dietary plant polyphenols are capable of counteracting by modulating different key molecular targets at the cell, as well as through epigenetic modifications. Hibiscus sabdariffa (HS)-derived polyphenols are known to ameliorate various obesity-related conditions. Recent evidence leads to propose the complex nature of the underlying mechanism of action...
August 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28820474/significance-of-resveratrol-in-clinical-management-of-chronic-diseases
#11
REVIEW
Awais Wahab, Kuo Gao, Caixia Jia, Feilong Zhang, Guihua Tian, Ghulam Murtaza, Jianxin Chen
Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases...
August 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28819580/analytical-method-for-the-validation-of-three-polyphenols-as-a-marker-compound-for-the-standardization-of-solidago-virgaurea-subsp-gigantea-extracts-and-antiadipogenesis-of-harvesting-time-and-location
#12
Seung Hwan Hwang, Ju Hee Kim, Zhiqiang Wang, Jae-Yong Lee, Soon Sung Lim
Protocatechuic acid (PC), chlorogenic acid (CA), and kaempferol-3-O-rutinoside (K-O-R), isolated from the Solidago virgaurea subsp. gigantea (SV) extract, were quickly and efficiently separated using HPLC. Our chromatographic method was found to effectively separate PC, CA, and K-O-R at retention times of 5.36, 8.22, and 17.04 min, respectively. Linearity of PC, CA, and K-O-R was found to be in the range of 4.85-485.00, 47.5-1900.00, and 8.50-850.00 μg/ml. Recoveries ranged between 101.32 and 103.30%, 95...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28805446/epigallocatechin-gallate-as-an-anti-obesity-therapeutic-compound-an-in-silico-approach-for-structure-based-drug-designing
#13
Muhammad Shahid Javaid, Noreen Latief, Bushra Ijaz, Usman Ali Ashfaq
Epigallocatechin gallate is a polyphenol of tea plants. Other than tea its trace amounts are found in apple skin, onions and plums. It has anti-adipogenic and anti-oxidant potential. It was investigated that epigallocatechin gallate stopped the adipogenic differentiation of mice mesenchymal stem cells but its underlying mechanism is not well understood. Different proteins and transcription factors responsible for differentiation of adipocytes could be its targets. This study was designed to determine the potential target of epigallocatechin gallate in human...
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28758919/research-progress-in-the-modification-of-quercetin-leading-to-anticancer-agents
#14
REVIEW
Alessandro Massi, Olga Bortolini, Daniele Ragno, Tatiana Bernardi, Gianni Sacchetti, Massimo Tacchini, Carmela De Risi
The flavonoid quercetin (3,3',4',5,7-pentahydroxyflavone) is widely distributed in plants, foods, and beverages. This polyphenol compound exhibits varied biological actions such as antioxidant, radical-scavenging, anti-inflammatory, antibacterial, antiviral, gastroprotective, immune-modulator, and finds also application in the treatment of obesity, cardiovascular diseases and diabetes. Besides, quercetin can prevent neurological disorders and exerts protection against mitochondrial damages. Various in vitro studies have assessed the anticancer effects of quercetin, although there are no conclusive data regarding its mode of action...
July 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28754022/unfolding-novel-mechanisms-of-polyphenol-flavonoids-for-better-glycaemic-control-targeting-pancreatic-islet-amyloid-polypeptide-iapp
#15
REVIEW
Ivana R Sequeira, Sally D Poppitt
Type 2 diabetes (T2D) is characterised by hyperglycaemia resulting from defective insulin secretion, insulin resistance, or both. The impact of over-nutrition and reduced physical activity, evidenced by the exponential rise in obesity and the prevalence of T2D, strongly supports the implementation of lifestyle modification programs. Accordingly, an increased consumption of fruits and plant-derived foods has been advocated, as their intake is inversely correlated with T2D prevalence; this has been attributed, in part, to their contained polyphenolic compounds...
July 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28748997/-role-of-mediterranean-diet-on-the-prevention-of-alzheimer-disease
#16
REVIEW
Arnoldo Miranda, Carolina Gómez-Gaete, Sigrid Mennickent
Type 2 diabetes and obesity are possible risk factors for Alzheimer’s disease and these can be modified by physical activity and changes in dietary patterns, such as switching to a Mediterranean diet. This diet includes fruits, vegetables, olive oil, fish and moderate wine intake. These foods provide vitamins, polyphenols and unsaturated fatty acids. This diet should be able to reduce oxidative stress. The inflammatory response is also reduced by unsaturated fatty acids, resulting in a lower expression and a lower production of pro-inflammatory cytokines...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28747010/traditional-knowledge-to-clinical-trials-a-review-on-therapeutic-actions-of-emblica-officinalis
#17
REVIEW
Suraj Singh Yadav, Manish Kumar Singh, Pawan Kumar Singh, Vipin Kumar
Plants are the integral part of the traditional indigenous healthcare system and are becoming concrete source of new drug discovery, evident by the increasing numbers of modern drugs derived from the phytochemicals. Emblica officinalis Gaertn. or Phyllanthus emblica Linn (family Phyllanthaceae) has been explained extensively and well documented for its therapeutic efficacies in indigenous system of medicine, in India. Every part of this plant possesses high medicinal value but fruits are the most valuable part in folklore and therapeutic uses...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28745498/curcumin-and-salsalate-suppresses-colonic-inflammation-and-procarcinogenic-signaling-in-high-fat-fed-azoxymethane-treated-mice
#18
Xian Wu, Anna C Pfalzer, Gar Yee Koh, Sanyuan Tang, Jimmy W Crott, Michael J Thomas, Mohsen Meydani, Joel B Mason
High-fat diets (HFDs) and excess adiposity increase proinflammatory cytokines in the colon, altering gene expression in a manner that promotes the development of colorectal cancer (CRC). Thus, compounds that reduce this biochemical inflammation are potential chemopreventive agents. Curcumin (CUR), a dietary polyphenol, and salsalate (SAL), a non-steroidal anti-inflammatory drug, are both anti-inflammatories. We investigated the inhibitory effects of CUR with or without SAL on inflammatory cytokines and procarcinogenic signaling in azoxymethane (AOM)-treated A/J mice...
August 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28741853/application-of-nir-spectroscopy-coupled-with-pls-regression-for-quantification-of-total-polyphenol-contents-from-the-fruit-and-aerial-parts-of-citrullus-colocynthis
#19
Tania S Rizvi, Fazal Mabood, Liaqat Ali, Mohammed Al-Broumi, Hamida K M Al Rabani, Javid Hussain, Farah Jabeen, Suryyia Manzoor, Ahmed Al-Harrasi
INTRODUCTION: Citrullus colocynthis (L.) Schrad is extensively used to treat diabetes, obesity, fever, cancer, amenorrhea, jaundice, leukemia, rheumatism, and respiratory diseases. Chemical studies have indicated the presence of several cucurbitacins, flavones, and other polyphenols in this plant. These phytochemical constituents are responsible for the interesting antioxidant and other biological activities of C. colocynthis. OBJECTIVE: In the present study, for the first time, near infrared (NIR) spectroscopy coupled with partial least square (PLS) regression analysis was used to quantify the polyphenolic phytochemicals of C...
July 25, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28739640/egcg-ameliorates-high-fat-and-high-fructose-induced-cognitive-defects-by-regulating-the-irs-akt-and-erk-creb-bdnf
#20
Yashi Mi, Guoyuan Qi, Rong Fan, Qinglian Qiao, Yali Sun, Yuqi Gao, Xuebo Liu
Obesity, which is caused by an energy imbalance between calorie intake and consumption, has become a major international health burden. Obesity increases the risk of insulin resistance and age-related cognitive decline, accompanied by peripheral inflammation. (-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, possesses antioxidant, anti-inflammatory, and cardioprotective activities; however, few reports have focused on its potential effect on cognitive disorders. In this study, our goal was to investigate the protective effects of EGCG treatment on insulin resistance and memory impairment induced by a high-fat and high-fructose diet (HFFD)...
July 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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