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https://www.readbyqxmd.com/read/28938189/the-potent-suppressive-effect-of-%C3%AE-d-mannuronic-acid-m2000-on-molecular-expression-of-the-tlr-nf-kb-signaling-pathway-in-ankylosing-spondylitis-patients
#1
Maryam Roozbehkia, Mahdi Mahmoudi, Somaye Aletaha, Nima Rezaei, Mohammad Javad Fattahi, Fahimeh Jafarnezhad-Ansariha, Anis Barati, Abbas Mirshafiey
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterized by the inflammation of sacroiliac joints and axial skeleton. A combination of genetic, environmental and immunological factors are involved in AS's pathogenesis. TLRs are type I transmembrane glycoproteins that play a crucial role in the innate immune responses against invading pathogens. Observational studies have demonstrated a possible association between TLR dysregulation and AS. The β-d-mannuronic acid (M2000), as a novel NSAID with immunosuppressive property, has shown an inhibitory effect on Toll-like receptor (TLR) 2, 4 signaling in HEK293 cells...
September 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28937279/reply-to-mri-assessment-of-sacroiliac-joints-according-to-assessment-in-spondyloarthritis-international-society-criteria
#2
Ali Özgen
No abstract text is available yet for this article.
October 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28937275/mri-assessment-of-sacroiliac-joints-according-to-assessment-of-spondyloarthritis-international-society-criteria
#3
Ali Kemal Sivrioglu, Serkan Aribal, Okan Ince
No abstract text is available yet for this article.
October 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28934785/1-year-results-of-a-randomized-controlled-trial-of-conservative-management-vs-minimally-invasive-surgical-treatment-for-sacroiliac-joint-pain
#4
Julius Dengler Dengler, Djaya Kools, Robert Pflugmacher, Alessandro Gasbarrini, Domenico Prestamburgo, Paolo Gaetani, Eddie van Eeckhoven, Daniel Cher, Bengt Sturesson
BACKGROUND: Low back pain (LBP) emanating from the sacroiliac joint (SIJ) is a common finding. Devices to fuse the SIJ are now commercially available, but high-quality evidence supporting their effectiveness is limited. OBJECTIVES: To compare the safety and effectiveness of conservative management (CM) to minimally invasive sacroiliac joint fusion (SIJF) in patients with chronic LBP originating from the SIJ. STUDY DESIGN: Prospective, multicenter randomized controlled trial...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28932014/the-effectiveness-of-physiotherapy-interventions-for-sacroiliac-joint-dysfunction-a-systematic-review
#5
REVIEW
Moayad Al-Subahi, Mohamed Alayat, Mansour Abdullah Alshehri, Omar Helal, Hammad Alhasan, Ahmed Alalawi, Abdullah Takrouni, Ali Alfaqeh
[Purpose] The aim of this study is to investigate the effectiveness of physical therapy interventions in the treatment of sacroiliac joint dysfunction (SIJD). [Subjects and Methods] MEDLINE, PUBMED, CINAHL, AMED, PEDro, and CIRRIE databases were searched and only relevant data from studies that matched the inclusion criteria were included. CASP tools for critical appraisal were used to assess the quality of studies included. [Results] Nine articles met the inclusion criteria, of which, three examined the effect of exercise on SIJD, three used kinesio tape and four studies examined the effect of manipulation...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28922873/long-term-reduction-of-sacroiliac-joint-pain-with-peripheral-nerve-stimulation
#6
Marin Guentchev, Christian Preuss, Rainer Rink, Levente Peter, Martin H M Sailer, Jochen Tuettenberg
BACKGROUND: We recently demonstrated that 86% of the patients treated with peripheral nerve stimulation (PNS) for therapy-refractory sacroiliac joint (SIJ) pain were satisfied with the result after 1 year of treatment. OBJECTIVE: To investigate the long-term (up to 4 years) response rate of this novel treatment. METHODS: Sixteen consecutive patients with therapy-refractory SIJ pain were treated with PNS and followed for 4 years in 3 patients, 3 years in 6 patients, and 2 years in 1 patient...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28910361/fever-as-an-initial-manifestation-of-spondyloarthritis-a-retrospective-study
#7
Se Jin Byun, William Han Bae, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
OBJECTIVES: We aimed to evaluate a wide spectrum of clinical features of adult patients with spondyloarthritis (SpA) whose initial manifestation was fever, using the Assessment of SpondyloArthritis international Society (ASAS) classification criteria. METHODS: We retrospectively collected the electronic medical records of hospitalized SpA patients who initially presented to the Severance Hospital (Seoul, Korea) with fever from January 2010 to May 2016. As a control group, we also recruited one-hundred consecutive patients who were diagnosed with SpA in our outpatient clinic...
2017: PloS One
https://www.readbyqxmd.com/read/28905097/color-doppler-and-spectral-doppler-ultrasound-detection-of-active-sacroiliitis-in-spondyloarthritis-compared-to-physical-examination-as-gold-standard
#8
Concepción Castillo-Gallego, Eugenio De Miguel, Miriam García-Arias, Chamaida Plasencia, Leticia Lojo-Oliveira, Emilio Martín-Mola
Sacroiliac joint (SIJ) involvement is a distinctive feature of spondyloarthritis (SpA). The main objective of this study was to assess the validity of color Doppler ultrasound (CDUS) in SIJ. This was a cross-sectional, blinded, case-control study of 108 cases divided into three groups: (a) 53 SpA patients with inflammatory back pain (IBP); (b) 28 SpA patients with no IBP; and (c) 27 healthy mechanical lumbar pain subjects. Physical examinations of the SIJs were assessed as positive or negative in each SIJ and were used as the gold standard...
September 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28902756/sacroiliac-joint-dysfunction-in-the-athlete-diagnosis-and-management
#9
Rebecca Peebles, Christopher E Jonas
Sacroiliac joint (SIJ) dysfunction is a common cause of low back pain in the athlete, especially in sports with repetitive, asymmetric loading. Complex anatomy and broad pain referral pattern make diagnosis difficult. Identifying three or more positive physical examination maneuvers for the SIJ improves examination sensitivity and specificity. Imaging is rarely helpful in establishing the diagnosis but is often used to rule out other pathology. Conservative management with activity modification, medication, physical therapy, manipulation and bracing is first line treatment...
September 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28890658/magnetic-resonance-imaging-of-the-axial-skeleton-in-patients-with-spondyloarthritis-distribution-pattern-of-inflammatory-and-structural-lesions
#10
Patrick Hoffstetter, Mohammed H Al Suwaidi, Alexander Joist, Achim Benditz, Martin Fleck, Christian Stroszczynski, Christian Dornia
PURPOSE: Spondyloarthritis is a chronic inflammatory disorder of the musculoskeletal system driven by systemic enthesitis and typically involving the axial skeleton, ie, the spine and the sacroiliac joints. The purpose of this study was to assess the distribution pattern of inflammatory and structural magnetic resonance imaging (MRI) findings in spondyloarthritis. METHODS: Retrospective study of 193 patients with axial spondyloarthritis who received MRI of the spine and the sacroiliac joints...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28885332/comparisons-of-front-plate-percutaneous-sacroiliac-screws-and-sacroiliac-anterior-papilionaceous-plate-in-fixation-of-unstable-pelvic-fractures
#11
Ronghe Gu, Weiguo Huang, Lijing Yang, Huijiang Liu, Kegong Xie, Zonggui Huang
BACKGROUND: This observational study was aimed at comparing the clinical efficacy of sacroiliac anterior plate fixation (SAPF), sacroiliac anterior papilionaceous plate (SAPP), and percutaneous sacroiliac screw internal fixation (PSCIF) introduced for patients with unstable pelvic fracture. METHODS: Seventy-eight patients with unstable pelvic fracture (Tile type B or C) were recruited. Twenty-six patients underwent SAPF, 26 underwent SAPP, and 26 underwent PSCIF...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28878533/the-importance-of-pelvic-ring-stabilization-as-a-life-saving-measure-in-pre-hospital-a-case-report-commented-by-autopsy
#12
Carlos Durão, Magda Alves, André Barros, Frederico Pedrosa
Hip fractures with unstable pelvic ring have great morbidity and mortality rates. These fractures result from high energy trauma such as falls from heights, road accidents and collapsing structures or other similar mechanisms of action. We report the case of a 63 years old man, construction worker, who stood inside a ditch during a wall construction when he was surprised by this collapse, which resulted in direct trauma to the right thigh and pelvis. The autopsy revealed diaphysis fracture of the right femur with an open book pelvic fracture with severe hemorrhagic infiltration and hematoma of the pelvic muscles without arterial injury...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28878511/management-of-the-open-book-apc-ii-pelvis-survey-results-from-pelvic-and-acetabular-surgeons-in-the-united-kingdom
#13
James R Gill, Colin Murphy, Ben Quansah, Andrew Carrothers
The results of this questionnaire show that the opinion of pelvic and acetabular surgeons in the UK and Republic of Ireland vary as to the best method of fixation for APC II pelvic injuries. A single anterior plate and single sacroiliac joint (SIJ) screw was the most popular fixation method, chosen by 34%. 74% favour a single, opposed to two orthogonal anterior plates. Posterior fixation supplementing anterior plating is preferred by 63% of surgeons, 58% use a single versus 42% two SIJ screws. Case by case assessment and intraoperative screening to assess stability is essential when considering whether to stabilise the SIJ...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28878452/the-effects-of-spinal-support-device-on-pain-and-extensibility-of-the-hamstrings-in-patients-with-non-specific-low-back-pain
#14
Eun Tae Jeon, Jin-Hwa Jung, Jong Hoon Moon, Kyoung-Sim Jung, Young Sik Won, Sung-Jin Kim, Suk-Chan Hahm, Hwi-Young Cho
[Purpose] The objective of this study was to investigate the effects of spinal support device (SSD) on pain and hamstring extensibility in patients with non-specific low back pain (NSLBP). [Subjects and Methods] 20 patients with NSLBP were recruited and randomly assigned to either the SSD group or the control group. In the SSD group, SSD was applied; in the control group, bed rest in supine position was performed. Both groups underwent treatment 20 min/day, 3 times a week, for a duration of 4 weeks. To assess the hamstring extensibility, sit and reach test (SRT) was performed...
August 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28866262/groin-pain-associated-with-sacroiliac-joint-dysfunction-and-lumbar-disorders
#15
Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa
OBJECTIVE: We investigated the prevalence of groin pain in patients with sacroiliac joint (SIJ) dysfunction, lumbar spinal canal stenosis (LSS), and lumbar disc herniation (LDH) who did not have hip disorders, and evaluated the clinical features that distinguished SIJ dysfunction from LSS and LDH. PATIENT AND METHODS: We evaluated 127 patients (57 men, 70 women, average age 55 years) with SIJ dysfunction, 146 (98 men, 48 women, average age 71 years) with LSS, and 124 (83 men, 41 women, average age 50 years) with LDH...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28865223/improvement-of-dairy-cow-embryo-yield-with-low-level-laser-irradiation
#16
G Palubinskas, V Žilaitis, R Antanaitis
The goal of this study is to estimate the effects of low-level laser irradiation (LLLI) on the superovulatory response according to the number of corpora lutea (CL), follicles (F) and the embryo yield. In recent years, while searching for new, more efficient and organic methods to improve superovulatory response and embryo yield with respect to the conventional methods, low-level laser irradiation (LLLI) is a more sensitive and less costly technology that can be used to improve animal reproduction, namely, artificial insemination and the embryo production system...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28838880/innervation-of-the-anterior-sacroiliac-joint
#17
Marcus Cox, Garrett Ng, Faizullah Mashriqi, Joe Iwanaga, Fernando Alonso, Kevin Tubbs, Marios Loukas, Rod J Oskouian, R Shane Tubbs
OBJECTIVE: Sacroiliac joint pain can be disabling and recalcitrant to medical therapy. The innervation of this joint is poorly understood, especially its anterior aspect. Therefore, the present cadaveric study was performed to better elucidate this anatomy. METHODS: Twenty-four cadaveric sides underwent dissection of the anterior sacroiliac joint with special attention given to any branches from regional nerves to this joint. RESULTS: No femoral, obturator, or lumbosacral trunk branches destined to the anterior sacroiliac joint were identified in the 24 sides...
August 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28822009/urolithiasis-as-an-extraarticular-manifestation-of-ankylosing-spondylitis
#18
REVIEW
Cengiz Korkmaz, Döndü Üsküdar Cansu, John A Sayer
Ankylosing spondylitis (AS) affects sacroiliac and axial joints as well as extraarticular organs, such as the eye, lung, bowel, and heart. Although examples of renal involvement in AS, such as IgA nephropathy, amyloidosis, and glomerulonephritis, have been reported, it has not been emphasized that urolithiasis is frequently formed in the clinical course of AS. Growing evidence indicates that urolithiasis may be observed in AS patients and is more frequent than other extraarticular features. In this review, we will discuss frequency and predictors of AS-related urolithiasis and summarize the possible underlying genetic and biochemical mechanisms...
August 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28819782/the-effects-of-%C3%AE-d-mannuronic-acid-m2000-as-a-novel-nsaid-on-cox1-and-cox2-activities-and-gene-expression-in-ankylosing-spondylitis-patients-and-the-murine-monocyte-macrophage-j774-cell-line
#19
Fahimeh Jafarnezhad-Ansariha, Mir Saeed Yekaninejad, Ahmad-Reza Jamshidi, Reza Mansouri, Mahdi Vojdanian, Mahdi Mahmoudi, Mohammad Javad Fattahi, Seyed Naser Hashemi, Bernd H A Rehm, Hidenori Matsuo, Emanuela Esposito, Salvatore Cuzzocrea, Abbas Mirshafiey
Ankylosing spondylitis (AS) is a debilitating chronic inflammatory disease with genetic predisposition, which is characterized by the involvement of spine and sacroiliac joints. Due to the relatively unsuccessful treatments, we designed β-D-mannuronic (M2000) with the beneficial effects in various experimental models as a novel non-steroidal anti-inflammatory drug (NSAID). The aims of our present study were: first, to compare the therapeutic effects of M2000, as a novel designed NSAID, with naproxen and placebo in Iranian patients with AS during 12 weeks; second, to evaluate the effect of M2000 on gene expression of cyclooxygenase enzyme (COX-1/COX-2), a key enzyme in the initiation of inflammatory pathways in AS patients; and third, to assess the activity of COX-1 and COX-2 enzymes in the presence/absence of M2000 at the different doses in the murine macrophage, J774 cell line...
August 17, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28812174/-magnetic-resonance-imaging-mri-diagnostics-in-axial-spondyloarthritis
#20
T Witte, X Baraliakos
BACKGROUND: Axial spondyloarthritis (axSpA) is a frequent disorder, which is difficult to diagnose in the early phase. Currently, magnetic resonance imaging (MRI) of the sacroiliac joints and the spine is frequently applied in this phase, when conventional X rays still provide inconclusive results. OBJECTIVE: To explain the typical pathological results and the role of MRI in diagnosing axSpA. RESULTS: The use of MRI of the sacroiliac joints plays a central role in the assessment of the Spondyloarthritis International Association Society (ASAS) classification criteria of axSpA...
August 15, 2017: Zeitschrift Für Rheumatologie
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