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JOURNAL ARTICLE
Ülkü Mete Ural
PURPOSE: The complications of surgical treatments of stress urinary incontinence have led to the search for less invasive and safer treatment procedures. We aimed to investigate the efficacy of locally administered injectable platelet-rich fibrin (i-PRF), an autologous material that plays an important role in tissue regeneration, in women with stress urinary incontinence. METHODS: Thirty-four women were included in this prospective, single-center, and interventional study, suffering from stress urinary incontinence refractory to conservative treatment...
February 29, 2024: Archives of Gynecology and Obstetrics
#2
Juanhong Pan, Hongpeng Li, Yongshen Wang, Li Lu, Ying Wang, Tianyu Zhao, Di Zhang, Song Jin
OBJECTIVE: To evaluate the effect of low-frequency (≤1 Hz) repetitive transcranial magnetic stimulation (low-frequency rTMS) combined with antidepressants on depression and the levels of inflammatory factors IL-6 and TNF-α in patients with post-stroke depression (PSD). DESIGN: PubMed, Embase, Web of Science, Cochrane Library (CBM), China National Knowledge Infrastructure, Technology Periodical Database, and Wanfang Database were searched until October 2022 for randomized controlled trials...
2023: Frontiers in Neurology
#3
RANDOMIZED CONTROLLED TRIAL
Chrysoula Stachtari, Zoi Stergiouda, Eleni Koraki, Freideriki Sifaki, Stella Bagntasarian, Stavros Chatzopoulos
OBJECTIVE: Regional techniques minimize anesthetic requirements and their effects may be beneficial. There is a lack of consensus and evidence concerning alternative analgesia strategies for cranial neurosurgery. This study was designed to evaluate the effect of scalp block with or without dexmedetomidine combined with general anesthesia on hemodynamic stability, opioid consumption and postoperative pain in patients undergoing elective craniotomy. METHODS: One hundred five patients undergoing elective craniotomy for tumor dissection were randomly divided into three groups to receive scalp block as an adjuvant to general anesthesia: with either 40 ml ropivacaine 0...
April 2023: Clinical Neurology and Neurosurgery
#4
JOURNAL ARTICLE
Shuangshuang Zhao, Zhipeng Shen, Juan Li, Lei Shi, Ni Zhang
RATIONALE: Outcomes remain poor in children with recurrent ependyomams (rEPNs), despite advances in surgery and radiotherapy. Systemic therapeutic options are limited, given the low response to chemotherapy and targeted drugs. There is an urgent need for efective pharmacotherapy. Apatinib is a multitarget tyrosine kinase inhibitor, which has been reported to exhibit broad antitumor profiles. However, its effects on rEPNs have not been reported thus far. PATIENT CONCERNS: We present a 5-year-old recurrent ependyomam patient benefting from apatinib and temozolomide...
September 16, 2022: Medicine (Baltimore)
#5
JOURNAL ARTICLE
Biao Duan, Jing Peng, Yi Zhang
BACKGROUND: Extraction of drug drug interactions from biomedical literature and other textual data is an important component to monitor drug-safety and this has attracted attention of many researchers in healthcare. Existing works are more pivoted around relation extraction using bidirectional long short-term memory networks (BiLSTM) and BERT model which does not attain the best feature representations. RESULTS: Our proposed DDI (drug drug interaction) prediction model provides multiple advantages: (1) The newly proposed attention vector is added to better deal with the problem of overlapping relations, (2) The molecular structure information of drugs is integrated into the model to better express the functional group structure of drugs, (3) We also added text features that combined the T-distribution and chi-square distribution to make the model more focused on drug entities and (4) it achieves similar or better prediction performance (F-scores up to 85...
August 14, 2022: BMC Bioinformatics
#6
JOURNAL ARTICLE
Diego Casas-Deza, Luis Javier Lamuela Calvo, Fernando Gomollón, José Miguel Arbonés Mainar, Berta Caballol, Javier P Gisbert, Montserrat Rivero, Eugenia Sánchez Rodríguez, Lara Arias García, Ana Gutiérrez Casbas, Olga Merino, Lucía Márquez, Viviana Laredo, María Dolores Martín-Arranz, Pilar López Serrano, Sabino Riestra Menéndez, Carlos González-Muñoza, Luisa de Castro Parga, Marta Calvo Moya, Esteban Fuentes-Valenzuela, Maria Esteve, Marisa Iborra, Miguel Dura Gil, Manuel Barreiro-De Acosta, Rufo Humberto Lorente Poyatos, Noemí Manceñido, Margalida Calafat, Iago Rodríguez Lago, Jordi Guardiola Capo, Maria Antonia Payeras, Víctor Jair Morales Alvarado, Carlos Tardillo, Luis Bujanda, José Fernando Muñoz Núñez, Yolanda Ber Nieto, Fernando Bermejo, Pedro Almela, Mercè Navarro-Llavat, Pilar Martínez Montiel, Cristina Rodríguez Gutiérrez, Manuel Van Domselaar, Eva Sesé, Teresa Martínez Pérez, Elena Ricart, María Chaparro, María José García, Antonio López-Sanromán, Beatriz Sicilia, Beatriz Orts, Alicia López García, Eduardo Martín-Larraz, José Lázaro Pérez Calle, Ruth de Francisco, Esther García-Planella, Eugeni Domènech, Y Santiago García-López
BACKGROUND AND AIMS: Clinical trials and real-life studies with ustekinumab in Crohn's disease (CD) have shown a good efficacy and safety profile. However, these data are scarcely available in elderly patients. Therefore, we aim to assess the effectiveness and safety of ustekinumab in elderly patients with CD. METHODS: Elderly patients (>60 years old) from the prospectively maintained ENEIDA registry treated with ustekinumab due to CD were included. Every patient was matched with two controls under 60 years of age, according to anti-TNF use and smoking habit...
August 1, 2022: Journal of Crohn's & Colitis
#7
REVIEW
Bruna Souza Felix Bravo, Stephanie Bianco, Julien Totti de Bastos, Raquel de Melo Carvalho
BACKGROUND: The aesthetic treatment based on fillers with hyaluronic acid presents an increasing demand in the present day because it is considered a safe and minimally invasive procedure. In the management of adverse effects or more severe complications of hyaluronic acid-based fillers, hyaluronidase is the treatment of choice. AIMS: To demonstrate efficacy in reversibility and safety in the treatment of HA complications. PATIENTS/METHODS: It is a retrospective study article that reports the use of hyaluronidase in the main undesirable effects of fillers in 114 patients in a private dermatological clinic from 2015 to 2018...
October 2021: Journal of Cosmetic Dermatology
#8
REVIEW
Qin Zeng, Xin-Hui Wang, Li-Ping Yang, Rui Lang, Ying Liang, Ren-Huan Yu
Shengxuening (SXN), as an effective supplement to heme-like iron, has been widely used in China to treat renal anemia. However, proof of its use for improving inflammation is scarce in the past decades. This work aimed to evaluate the effectiveness of SXN with inflammatory factors as primary endpoints. By searching PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM), VIP Information/ China Science and Technology Journal Database, and WANFANG Database, we identified previous studies that met the inclusion criteria and included them in the systematic review...
December 2020: Journal of Translational Internal Medicine
#9
REVIEW
Sai Kranthi Vanga, Vijaya Raghavan
"Tree nut" is a broad term for classification of nuts that include cashews, almonds, hazelnuts, etc. Reports of mild to adverse immune reactions following the consumption of these nuts has been on a rise in recent years. Currently, about 1.2-2% of the world's population suffer from sensitivity to tree nuts. The only solution is complete abstinence from the allergy causing tree nut which is not feasible in most cases due to issues like cross contamination or their presence in the form of hidden ingredients in processed foods...
November 22, 2017: Critical Reviews in Food Science and Nutrition
#10
Roman Prymula, Susanna Esposito, Gian Vincenzo Zuccotti, Fang Xie, Daniela Toneatto, Igor Kohl, Peter M Dull
The novel meningococcal serogroup B vaccine (4CMenB, Bexsero(®)), recently approved in Europe and Australia, may soon be included in routine infant immunization schedules, subject to guidance from national or regional recommending bodies. In the development of 4CMenB and consistent with other newly introduced vaccines, clinical studies have shown concomitant administration with routine infant vaccines induces an incremental increase in some reactions, including fever. As this may hinder acceptability, we examined the impact of prophylactic paracetamol on the occurrence of fever and other solicited reactions, as well as the immune responses to study vaccines, in a prospectively designed study...
April 24, 2014: Human Vaccines & Immunotherapeutics
#11
RANDOMIZED CONTROLLED TRIAL
S Iu Martsevich, S N Tolpygina, Iu V Lukina, V P Voronina, N V Kiseleva, E S Boĭchenko, R É Dubinskaia, E N Khoseva
The purpose of the study was a comparative study of antiplatelet activity of acetylsalicylic acid drugs, produced in gastro-resistant form trombopol 75 mg and aspirin cardio 100 mg in patients with high risk of cardiovascular events. Effect of trombopol 75 mg versus 100 mg aspirin cardio on platelet aggregation in 30 patients with high risk of cardiovascular events during 3 week treatment period was studied. Design method: blind, randomized, crossover method. Three weeks before the initial therapy, for those patients, who received antiplatelet platelet therapy at the time of inclusion in the study, this therapy was withdrew ("wash-out period"), after which patient was given one of the study drug (sequence of courses was s determined according to the scheme of randomization) with the recommendation of taking it daily in the morning at the same time...
2012: Kardiologiia
#12
RANDOMIZED CONTROLLED TRIAL
Dai-Rong Xiang, Ji-Fang Sheng
OBJECTIVE: To analyze the efficacy of adefovir dipivoxil combined with bicyclol in treatment of HBeAg-positive chronic viral hepatitis B (CHB). METHODS: A total of 91 patients with CHB were randomized into experimental group and control group to be treated. The patients in experimental group (46 samples) received adefovir dipivoxil orally 10 mg daily and bicyclol orally 150 mg daily for 48 weeks and those in control group (45 samples) received adefovir dipivoxil orally 10 mg daily alone for 48 weeks...
August 2009: Chinese Journal of Experimental and Clinical Virology
#13
REVIEW
Stephen Chia, William Gradishar
With the aromatase inhibitors (AIs) replacing tamoxifen as the first-line treatment for postmenopausal women with hormone receptor-positive early and advanced breast cancer, there is a need to evaluate appropriate endocrine treatment options following AI failure. However, until recently, there were no Phase III trial data in this area. Fulvestrant (Faslodex) is an oestrogen receptor antagonist utilised for the treatment of postmenopausal women with locally advanced or metastatic breast cancer following progression or recurrence on anti-oestrogen therapy...
April 2008: Breast: Official Journal of the European Society of Mastology
#14
RANDOMIZED CONTROLLED TRIAL
Stephen Chia, William Gradishar, Louis Mauriac, Jose Bines, Frederic Amant, Miriam Federico, Luis Fein, Gilles Romieu, Aman Buzdar, John F R Robertson, Adam Brufsky, Kurt Possinger, Pamela Rennie, Francisco Sapunar, Elizabeth Lowe, Martine Piccart
PURPOSE: The third-generation nonsteroidal aromatase inhibitors (AIs) are increasingly used as adjuvant and first-line advanced therapy for postmenopausal, hormone receptor-positive (HR+) breast cancer. Because many patients subsequently experience progression or relapse, it is important to identify agents with efficacy after AI failure. MATERIALS AND METHODS: Evaluation of Faslodex versus Exemestane Clinical Trial (EFECT) is a randomized, double-blind, placebo controlled, multicenter phase III trial of fulvestrant versus exemestane in postmenopausal women with HR+ advanced breast cancer (ABC) progressing or recurring after nonsteroidal AI...
April 1, 2008: Journal of Clinical Oncology
#15
COMPARATIVE STUDY
Juan Francisco Márquez Peiró, Victoria Eugenia Valero Alcocer, María Morales Suárez-Varela, Agustín Llopis González, Carmen Pérez Peiró
BACKGROUND AND OBJECTIVE: The adverse reactions (ADR) derived from the treatment of hepatitis C with peginterferon alpha and ribavirin causes dose reductions and discontinuations of the treatment that compromise its efectiveness. The aims of this study are to determine the ADR that the patients have presented according to the type of peginterferon alpha, and the effect of these in treatment duration and accumulated dose. PATIENTS AND METHOD: Cohort, prospective and longitudinal study (from November 2002 to April 2006), with monoinfected patients not previously treated (group A: peginterferon alpha-2a plus ribavirin; group B: peginterferon alpha-2b plus ribavirin)...
November 3, 2007: Medicina Clínica
#16
RANDOMIZED CONTROLLED TRIAL
Guillermo Torre-Amione, Cynthia K Wallace, James B Young, Michael M Koerner, Vinay Thohan, Susan McRee, Roberta C Bogaev
Cardiac allograft hypertrophy is associated with persistent expression of cardiac tumor necrosis factor (TNF)-alpha. We investigated whether TNFalpha antagonism would impact allograft hypertrophy. EFECT (EFfect of Etanercept on Cardiac Transplantation) was a randomized, controlled, double-blind trial evaluating the effect of etanercept versus placebo treatment immediately posttransplant. The primary end-point was change in left ventricular (LV) mass after 6 months. Secondary endpoints included degree of collagen deposition at 6 months and incidence of adverse events...
August 27, 2007: Transplantation
#17
JOURNAL ARTICLE
S Wang, K E Panter, D R Gardner, R C Evans, T D Bunch
Isocupressic acid (ICA) [15-hydroxylabda-8 (17), 13E-dien-19-oic acid], a labdane diterpene acid, isolated from ponderosa pine (Pinus ponderosa), Lodgepole pine (Pinus contorta), common juniper (Juniperus communis) and Monterey cypress (Cupressus macrocarpa), induces abortion in pregnant cows when ingested primarily during the last trimester. The objective of this study was to investigate the effects of isocupressic acid on bovine oocyte maturation (in vitro maturation (IVM)-Experiment I) and preimplantation embryo development (in vitro culture (IVC)-Experiment II) using in vitro embryo production techniques and to subsequently evaluate viability and developmental competence of ICA-cultured embryos via embryo transfer to recipient heifers (Experiment III)...
April 2004: Animal Reproduction Science
#18
JOURNAL ARTICLE
I Roch-Torreilles, W Camu, D Hillaire-Buys
Amyotrophic lateral sclerosis (ALS) is a rapidly fatal degenerative disorder of the motoneurones which was without any effective therapy until 1997. Riluzole (Rilutek) has been the first patented drug used in its specific treatment. In order to evaluate the tolerability profile of this molecule, a Pharmacovigilance study was undertaken in the Department of Neurology B at the Montpellier University Hospital. A total of 153 patients were studied and all observed side-effects were listed in the French bank of Pharmacovigilance...
March 2000: Thérapie
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