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Brain surface mri

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https://www.readbyqxmd.com/read/29053191/perceived-stress-is-associated-with-smaller-hippocampal-volume-in-adolescence
#1
Luciane R Piccolo, Kimberly G Noble
Perceived stress has been associated with decreased hippocampal, amygdala, and prefrontal cortex volume, as well as decreased memory and executive functioning performance in adulthood. Parents' perceived stress has been linked to decreased hippocampal volume in young children. However, no studies have investigated the links between self-perceived stress and brain structure or function in adolescents. Additionally, findings from previous research with younger or older samples are inconsistent, likely in part due to inconsistencies in participants' age range...
October 20, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29034964/hemispheric-asymmetry-of-the-frontolimbic-cortex-in-young-adults-with-borderline-personality-disorder
#2
Q Zhou, M Zhong, S Yao, X Jin, Y Liu, C Tan, X Zhu, J Yi
OBJECTIVE: Although the frontolimbic cortex has been implicated in borderline personality disorder (BPD), information about possible asymmetries in this region in patients with BPD is limited. This study aimed to examine whether frontolimbic cortex asymmetries differ between patients with BPD and healthy individuals. METHODS: The brains of 30 young adult patients with BPD and 32 healthy control subjects were scanned with magnetic resonance imaging (MRI). The participants completed self-report scales assessing impulsivity, affect intensity and other psychological variables...
October 16, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29025172/-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-paediatric-patients-with-optic-neuritis
#3
Helmut Tegetmeyer, Andreas Merkenschlager
Background Myelin oligodendrocyte glycoprotein (MOG) is located on the surface of oligodendrocytes and myelin in the central nervous system. MOG-IgG is associated with acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis (NNO), and transverse myelitis (TM) in both paediatric and adult patients. The combination of NNO and TM or other inflammatory brain lesions is a typical feature of neuromyelitis optica spectrum disorders (NMO-SD) which are associated with specific pathogenic autoantibodies against the water channel aquaporin-4 (AQP4-IgG)...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29023798/intrathecal-antibody-distribution-in-the-rat-brain-surface-diffusion-perivascular-transport-and-osmotic-enhancement-of-delivery
#4
Michelle E Pizzo, Daniel J Wolak, Niyanta N Kumar, Eric Brunette, Christina L Brunnquell, Melanie-Jane Hannocks, N Joan Abbott, M Elizabeth Meyerand, Lydia Sorokin, Danica B Stanimirovic, Robert G Thorne
The precise mechanisms governing the central distribution of macromolecules from the cerebrospinal fluid (CSF) to the brain and spinal cord remain poorly understood, despite their importance for physiological processes such as antibody trafficking for central immune surveillance as well as several ongoing intrathecal clinical trials. Here, we clarify how immunoglobulin G (IgG) and smaller single-domain antibodies (sdAb) distribute throughout the whole brain in a size-dependent manner after intrathecal infusion in rats using ex vivo fluorescence and in vivo 3D magnetic resonance imaging...
October 12, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28991694/dilemmas-in-the-diagnosis-and-treatment-of-intracranial-tuberculomas
#5
REVIEW
Rajeswari Ramachandran, M Muniyandi, Vijay Iyer, T Sripriya, B Priya, T G Govindarajan
Tuberculosis (TB) remains a major public health problem across the globe. A common form of extrapulmonary TB (EPTB) with high mortality and morbidity is neuro TB or tuberculosis of the nervous system. The management of brain TB remains a big challenge due to the lack of specific diagnostic tools and appropriate treatment guidelines. In this context, this manuscript discusses clinical, diagnostic and treatment dilemmas in the management of intracranial tuberculomas. Brain tuberculoma may occur at any site within the cranium, no part of the brain substance or ventricular surface being exempt...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28969373/glymphatic-mri-in-idiopathic-normal-pressure-hydrocephalus
#6
Geir Ringstad, Svein Are Sirirud Vatnehol, Per Kristian Eide
The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so far been limited to rodents. We aimed to image cerebrospinal fluid flow characteristics and glymphatic function in humans, and applied the methodology in a prospective study of 15 idiopathic normal pressure hydrocephalus patients (mean age 71...
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28968785/the-genetic-contributions-to-maturational-coupling-in-the-human-cerebrum-a-longitudinal-pediatric-twin-imaging-study
#7
J Eric Schmitt, Jay N Giedd, Armin Raznahan, Michael C Neale
Although prior studies have demonstrated that genetic factors play the dominant role in the patterning of the pediatric brain, it remains unclear how these patterns change over time. Using 1748 longitudinal anatomic MRI scans from 792 healthy twins and siblings, we quantified how genetically mediated inter-regional associations change over time via multivariate longitudinal structural equation modeling. These analyses found that genetic correlations for both lobar volumes and cortical thickness are dynamic, with relatively static effects on surface area...
August 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28968658/task-general-and-acoustic-invariant-neural-representation-of-speech-categories-in-the-human-brain
#8
Gangyi Feng, Zhenzhong Gan, Suiping Wang, Patrick C M Wong, Bharath Chandrasekaran
A significant neural challenge in speech perception includes extracting discrete phonetic categories from continuous and multidimensional signals despite varying task demands and surface-acoustic variability. While neural representations of speech categories have been previously identified in frontal and posterior temporal-parietal regions, the task dependency and dimensional specificity of these neural representations are still unclear. Here, we asked native Mandarin participants to listen to speech syllables carrying 4 distinct lexical tone categories across passive listening, repetition, and categorization tasks while they underwent functional magnetic resonance imaging (fMRI)...
August 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28965234/clinical-responses-of-patients-with-diffuse-leptomeningeal-glioneuronal-tumors-to-chemotherapy
#9
Dolly Aguilera, Robert Craig Castellino, Anna Janss, Mathew Schniederjan, Renee McNall, Tobey MacDonald, Claire Mazewski
INTRODUCTION: Diffuse leptomeningeal glioneuronal tumors (DLGT) have been recognized in the most recent WHO classification as a distinct entity. OBJECTIVE: We describe seven pediatric cases of DLGT and the responses to therapy and outcome. METHODS: We conducted a retrospective review of charts from 1985 to 2013. RESULTS: DBS is an effective therapeutic modality for intractable TLE, particularly in patients with lateralized EEG A total of seven patients were identified...
September 30, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28962808/herpes-virus-encephalitis-in-adults-current-knowledge-and-old-myths
#10
REVIEW
Alejandro A Rabinstein
Herpes simplex virus (HSV) encephalitis is uncommon in clinical practice, but is frequently suspected in patients with acute alterations of consciousness. Symptoms and physical signs are nonspecific, and diagnostic confirmation typically hinges on demonstration of viral DNA in cerebrospinal fluid. Brain MRI is helpful in diagnosis and provides prognostic information. Early initiation of intravenous acyclovir is essential to optimize the patient's chances of favorable recovery. HSV encephalitis can trigger an autoimmune reaction with the possible appearance of antibodies to neuronal surface antigens...
November 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28959704/cryptogenic-norse-its-distinctive-clinical-features-and-response-to-immunotherapy
#11
Takahiro Iizuka, Naomi Kanazawa, Juntaro Kaneko, Naomi Tominaga, Yutaka Nonoda, Atsuko Hara, Yuya Onozawa, Hiroki Asari, Takashi Hata, Junya Kaneko, Kenji Yoshida, Yoshihiro Sugiura, Yoshikazu Ugawa, Masashi Watanabe, Hitomi Tomita, Arifumi Kosakai, Atsushi Kaneko, Daisuke Ishima, Eiji Kitamura, Kazutoshi Nishiyama
OBJECTIVE: To report the distinctive clinical features of cryptogenic new-onset refractory status epilepticus (C-NORSE) and the C-NORSE score based on initial clinical assessments. METHODS: A retrospective study was conducted for 136 patients with clinically suspected autoimmune encephalitis who underwent testing for autoantibodies to neuronal surface antigens between January 1, 2007, and August 31, 2016. Eleven patients with C-NORSE were identified. Their clinical features were compared with those of 32 patients with anti-NMDA receptor encephalitis (NMDARE)...
November 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28959379/empowering-cortical-thickness-measures-in-clinical-diagnosis-of-alzheimer-s-disease-with-spherical-sparse-coding
#12
Jie Zhang, Yonghui Fan, Qingyang Li, Paul M Thompson, Jieping Ye, Yalin Wang
Cortical thickness estimation performed in vivo via magnetic resonance imaging (MRI) is an important technique for the diagnosis and understanding of the progression of Alzheimer's disease (AD). Directly using raw cortical thickness measures as features with Support Vector Machine (SVM) for clinical group classification only yields modest results since brain areas are not equally atrophied during AD progression. Therefore, feature reduction is generally required to retain only the most relevant features for the final classification...
April 2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28945310/brain-structural-correlates-of-irritability-findings-in-a-large-healthy-cohort
#13
Bianca Besteher, Letizia Squarcina, Robert Spalthoff, Marcella Bellani, Christian Gaser, Paolo Brambilla, Igor Nenadić
Irritability and nonviolent aggression are common behavioral features across the population, yet there is limited neurobiological research into subclinical phenotypes representing the lower edge of a symptom continuum ranging from slight irritability to criminal violence. We studied brain structural correlates of irritability in a large healthy cohort to test the hypothesis of associations with fronto-limbic brain structures implicated in mood regulation. In a large multicenter effort, we recruited 409 mentally healthy adults from the community, who received T1-weighted high-resolution 3 T MRI scans...
September 25, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28943848/multimodal-discrimination-of-schizophrenia-using-hybrid-weighted-feature-concatenation-of-brain-functional-connectivity-and-anatomical-features-with-an-extreme-learning-machine
#14
Muhammad Naveed Iqbal Qureshi, Jooyoung Oh, Dongrae Cho, Hang Joon Jo, Boreom Lee
Multimodal features of structural and functional magnetic resonance imaging (MRI) of the human brain can assist in the diagnosis of schizophrenia. We performed a classification study on age, sex, and handedness-matched subjects. The dataset we used is publicly available from the Center for Biomedical Research Excellence (COBRE) and it consists of two groups: patients with schizophrenia and healthy controls. We performed an independent component analysis and calculated global averaged functional connectivity-based features from the resting-state functional MRI data for all the cortical and subcortical anatomical parcellation...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28943701/automatic-falx-cerebri-and-tentorium-cerebelli-segmentation-from-magnetic-resonance-images
#15
Jeffrey Glaister, Aaron Carass, Dzung L Pham, John A Butman, Jerry L Prince
The falx cerebri and tentorium cerebelli are dural structures found in the brain. Due to the roles both structures play in constraining brain motion, the falx and tentorium must be identified and included in finite element models of the head to accurately predict brain dynamics during injury events. To date there has been very little research work on automatically segmenting these two structures, which is understandable given that their 1) thin structure challenges the resolution limits of in vivo 3D imaging, and 2) contrast with respect to surrounding tissue is low in standard magnetic resonance imaging...
February 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28940863/a-phase-ii-study-of-radioimmunotherapy-with-intraventricular-131-i-3f8-for-medulloblastoma
#16
Kim Kramer, Neeta Pandit-Taskar, John L Humm, Pat B Zanzonico, Sofia Haque, Ira J Dunkel, Suzanne L Wolden, Maria Donzelli, Debra A Goldman, Jason S Lewis, Serge K Lyashchenko, Yasmin Khakoo, Jorge A Carrasquillo, Mark M Souweidane, Jeffrey P Greenfield, David Lyden, Kevin D De Braganca, Stephen W Gilheeney, Steven M Larson, Nai-Kong V Cheung
BACKGROUND: High-risk and recurrent medulloblastoma (MB) is associated with significant mortality. The murine monoclonal antibody 3F8 targets the cell-surface disialoganglioside GD2 on MB. We tested the efficacy, toxicity, and dosimetry of compartmental radioimmunotherapy (cRIT) with intraventricular (131) I-labeled 3F8 in patients with MB on a phase II clinical trial. METHODS: Patients with histopathologically confirmed high-risk or recurrent MB were eligible for cRIT...
September 22, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28936280/enhancing-diffusion-mri-measures-by-integrating-grey-and-white-matter-morphometry-with-hyperbolic-wasserstein-distance
#17
Wen Zhang, Jie Shi, Jun Yu, Liang Zhan, Paul M Thompson, Yalin Wang
In order to improve the preclinical diagnose of Alzheimer's disease (AD), there is a great deal of interest in analyzing the AD related brain structural changes with magnetic resonance image (MRI) analyses. As the major features, variation of the structural connectivity and the cortical surface morphometry provide different views of structural changes to determine whether AD is present on presymptomatic patients. However, the large scale tensor-valued information and relatively low imaging resolution in diffusion MRI (dMRI) have created huge challenges for analysis...
2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28933214/magnetic-enhancement-of-stem-cell-targeted-delivery-into-the-brain-following-mr-guided-focused-ultrasound-for-opening-the-blood-brain-barrier
#18
Wei-Bin Shen, Pavlos Anastasiadis, Ben Nguyen, Deborah Yarnell, Paul J Yarowsky, Victor Frenkel, Paul S Fishman
Focused ultrasound (FUS)-mediated blood-brain barrier disruption (BBBD) can enable even large therapeutics such as stem cells to enter the brain from the bloodstream. However, the efficiency is relatively low. Our previous study showed that human neural progenitor cells (hNPCs) loaded with superparamagnetic iron oxide nanoparticles (SPIONs) in culture were attracted by an external magnetic field. In vivo, enhanced brain retention was observed near a magnet mounted on the skull in a rat model of traumatic brain injury, where BBBD also occurs...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28928491/freezing-of-gait-is-associated-with-cortical-thinning-in-mesial-frontal-cortex
#19
Miroslav Vastik, Pavel Hok, Jan Valosek, Petr Hlustik, Katerina Mensikova, Petr Kanovsky
AIMS: The relationship between freezing of gait (FOG) and regional brain atrophy has been intensively investigated, but it is still not clearly understood. The study objective was to test whether grey matter (GM) atrophy contributes to FOG in Parkinson´s disease (PD) using a surface-based algorithm. METHODS: We investigated 21 patients with PD, 11 with FOG and 10 without FOG. Both groups were assessed using a FOG questionnaire and Hoehn and Yahr staging. High resolution T1-weighted brain images were acquired for each subject using a 1...
September 13, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28924573/retrospective-study-comparing-model-based-deformation-correction-to-intraoperative-magnetic-resonance-imaging-for-image-guided-neurosurgery
#20
Ma Luo, Sarah F Frisken, Jared A Weis, Logan W Clements, Prashin Unadkat, Reid C Thompson, Alexandra J Golby, Michael I Miga
Brain shift during tumor resection compromises the spatial validity of registered preoperative imaging data that is critical to image-guided procedures. One current clinical solution to mitigate the effects is to reimage using intraoperative magnetic resonance (iMR) imaging. Although iMR has demonstrated benefits in accounting for preoperative-to-intraoperative tissue changes, its cost and encumbrance have limited its widespread adoption. While iMR will likely continue to be employed for challenging cases, a cost-effective model-based brain shift compensation strategy is desirable as a complementary technology for standard resections...
July 2017: Journal of Medical Imaging
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