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Brain surface mri

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https://www.readbyqxmd.com/read/27903329/prediction-of-free-and-cued-selective-reminding-test-performance-using-volumetric-and-amyloid-based-biomarkers-of-alzheimer-s-disease
#1
Lisa Quenon, Laurence Dricot, John L Woodard, Bernard Hanseeuw, Nathalie Gilis, Renaud Lhommel, Adrian Ivanoiu
OBJECTIVES: Relatively few studies have investigated relationships between performance on clinical memory measures and indexes of underlying neuropathology related to Alzheimer's disease (AD). This study investigated predictive relationships between Free and Cued Selective Reminding Test (FCSRT) cue efficiency (CE) and free-recall (FR) measures and brain amyloid levels, hippocampal volume (HV), and regional cortical thickness. METHODS: Thirty-one older controls without memory complaints and 60 patients presenting memory complaints underwent the FCSRT, amyloid imaging using [F18]-flutemetamol positron emission tomography, and surface-based morphometry (SBM) using brain magnetic resonance imaging...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27894944/surface-projected-flair-supr-flair-analysis-a-novel-tool-for-advanced-imaging-of-epilepsy
#2
Francesco Cardinale, Stefano Francione, Luciana Gennari, Alberto Citterio, Maurizio Sberna, Laura Tassi, Roberto Mai, Ivana Sartori, Lino Nobili, Massimo Cossu, Laura Castana, Giorgio Lo Russo, Nadia Colombo
OBJECTIVE: The objective of this pilot retrospective study is to describe the SUrface-PRojected FLuid-Attenuation-Inversion-Recovery (SUPR-FLAIR) analysis, a novel method mainly aimed at revealing cortical areas with subtle signal hyper-intensity. METHODS: Images from 101 healthy controls and ten patients suffering from drug-resistant partial epilepsy were retrospectively post-processed. Brain surface was reconstructed from a 3D T1-weighted fast field echo (3D T1W-FFE) MRI scan...
November 25, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27893017/evaluation-of-cognitive-deficits-and-structural-hippocampal-damage-in-encephalitis-with-leucine-rich-glioma-inactivated-1-antibodies
#3
Carsten Finke, Harald Prüss, Josephine Heine, Sigrid Reuter, Ute A Kopp, Florian Wegner, Florian Then Bergh, Sebastian Koch, Olav Jansen, Thomas Münte, Günther Deuschl, Klemens Ruprecht, Winfried Stöcker, Klaus-Peter Wandinger, Friedemann Paul, Thorsten Bartsch
Importance: Limbic encephalitis with leucine-rich, glioma-inactivated 1 (LGI1) antibodies is one of the most frequent variants of autoimmune encephalitis with antibodies targeting neuronal surface antigens. However, the neuroimaging pattern and long-term cognitive outcome are not well understood. Objective: To study cognitive outcome and structural magnetic resonance imaging (MRI) alterations in patients with anti-LGI1 encephalitis. Design, Setting, and Participants: A cross-sectional study was conducted at the Departments of Neurology at Charité-Universitätsmedizin Berlin and University Hospital Schleswig-Holstein, Kiel, Germany...
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27874271/diagnostic-model-generated-by-mri-derived-brain-features-in-toddlers-with-autism-spectrum-disorder
#4
Xiang Xiao, Hui Fang, Jiansheng Wu, ChaoYong Xiao, Ting Xiao, Lu Qian, FengJing Liang, Zhou Xiao, Kang Kang Chu, Xiaoyan Ke
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with core symptoms of atypical social interaction, communication, and restricted, repetitive patterns of behavior, interests, and activities. Although the pathophysiologic mechanism of ASD is unclarified yet, the neuroanatomical features are considered as valuable predictors for discriminating ASD from others. But there has been relatively little scientific study about predictive power of different neuroanatomical features of early age ASD...
November 22, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27872808/delineation-of-cortical-pathology-in-multiple-sclerosis-using-multi-surface-magnetization-transfer-ratio-imaging
#5
David A Rudko, Mishkin Derakhshan, Josefina Maranzano, Kunio Nakamura, Douglas L Arnold, Sridar Narayanan
The purpose of our study was to evaluate the utility of measurements of cortical surface magnetization transfer ratio (csMTR) on the inner, mid and outer cortical boundaries as clinically accessible biomarkers of cortical gray matter pathology in multiple sclerosis (MS). Twenty-five MS patients and 12 matched controls were recruited from the MS Clinic of the Montreal Neurological Institute. Anatomical and magnetization transfer ratio (MTR) images were acquired using 3 Tesla MRI at baseline and two-year time-points...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27862643/the-moderating-effects-of-sex-on-insula-subdivision-structure-in-youth-with-posttraumatic-stress-symptoms
#6
Megan Klabunde, Carl F Weems, Mira Raman, Victor G Carrion
BACKGROUND: The insula is involved in interoceptive processing, emotion awareness, and attention to salient stimuli. Research suggests that these functions are specific-albeit overlapping-within insula subdivisions. Additional studies also imply that sexual dimorphism and different rates of development occur within these subdivisions in youth. The purpose of this study was to examine potential insula subdivision structure differences in youth with PTSD symptoms as compared to controls and test sex as a moderator of these differences...
November 11, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27857050/central-nervous-system-lymphoma-a-morphological-mri-study
#7
(no author information available yet)
OBJECTIVES: The aim of the present study was to evaluate morphological MRI findings in histologically-proven central nervous system lymphoma (CNSL) at time of their first appearance, and to describe dynamic changes on repeat MRI before the diagnosis was histologically proven. METHODS: We retrospectively evaluated the MRI examinations of 74 patients with histologically-proven CNSL (10 secondary CNSL, 64 primary PCNSL; 10 immunocompromised, 54 immunocompetent). In 43 patients, we evaluated the evolution of CNSL on MRI before the diagnosis was proven...
September 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27845915/automatic-metastatic-brain-tumor-segmentation-for-stereotactic-radiosurgery-applications
#8
Yan Liu, Strahinja Stojadinovic, Brian Hrycushko, Zabi Wardak, Weiguo Lu, Yulong Yan, Steve B Jiang, Robert Timmerman, Ramzi Abdulrahman, Lucien Nedzi, Xuejun Gu
The objective of this study is to develop an automatic segmentation strategy for efficient and accurate metastatic brain tumor delineation on contrast-enhanced T1-weighted (T1c) magnetic resonance images (MRI) for stereotactic radiosurgery (SRS) applications. The proposed four-step automatic brain metastases segmentation strategy is comprised of pre-processing, initial contouring, contour evolution, and contour triage. First, T1c brain images are preprocessed to remove the skull. Second, an initial tumor contour is created using a multi-scaled adaptive threshold-based bounding box and a super-voxel clustering technique...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27843694/grey-matter-abnormalities-in-methcathinone-abusers-with-a-parkinsonian-syndrome
#9
Julius Juurmaa, Ricarda A L Menke, Pierre Vila, Andreas Müürsepp, Tiiu Tomberg, Pilvi Ilves, Mait Nigul, Heidi Johansen-Berg, Michael Donaghy, Charlotte J Stagg, Ainārs Stepens, Pille Taba
BACKGROUND: A permanent Parkinsonian syndrome occurs in intravenous abusers of the designer psychostimulant methcathinone (ephedrone). It is attributed to deposition of contaminant manganese, as reflected by characteristic globus pallidus hyperintensity on T1-weighted MRI. METHODS: We have investigated brain structure and function in methcathinone abusers (n = 12) compared to matched control subjects (n = 12) using T1-weighted structural and resting-state functional MRI...
November 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27830632/alcohol-use-is-associated-with-thinner-cerebral-cortex-and-larger-ventricles-in-schizophrenia-bipolar-disorder-and-healthy-controls
#10
E H Lange, S Nerland, K N Jørgensen, L Mørch-Johnsen, R Nesvåg, C B Hartberg, U K Haukvik, K Osnes, I Melle, O A Andreassen, I Agartz
BACKGROUND: Excessive alcohol use is associated with brain damage but less is known about brain effects from moderate alcohol use. Previous findings indicate that patients with severe mental illness, particularly schizophrenia, are vulnerable to alcohol-related brain damage. We investigated the association between levels of alcohol consumption and cortical and subcortical brain structures in schizophrenia and bipolar disorder patients and healthy controls, and investigated for group differences for this association...
November 10, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27812129/patterns-of-individual-variation-in-visual-pathway-structure-and-function-in-the-sighted-and-blind
#11
Geoffrey K Aguirre, Ritobrato Datta, Noah C Benson, Sashank Prasad, Samuel G Jacobson, Artur V Cideciyan, Holly Bridge, Kate E Watkins, Omar H Butt, Aleksandra S Dain, Lauren Brandes, Efstathios D Gennatas
Many structural and functional brain alterations accompany blindness, with substantial individual variation in these effects. In normally sighted people, there is correlated individual variation in some visual pathway structures. Here we examined if the changes in brain anatomy produced by blindness alter the patterns of anatomical variation found in the sighted. We derived eight measures of central visual pathway anatomy from a structural image of the brain from 59 sighted and 53 blind people. These measures showed highly significant differences in mean size between the sighted and blind cohorts...
2016: PloS One
https://www.readbyqxmd.com/read/27807185/gray-matter-mri-differentiates-neuromyelitis-optica-from-multiple-sclerosis-using-random-forest
#12
Arman Eshaghi, Viktor Wottschel, Rosa Cortese, Massimiliano Calabrese, Mohammad Ali Sahraian, Alan J Thompson, Daniel C Alexander, Olga Ciccarelli
OBJECTIVE: We tested whether brain gray matter (GM) imaging measures can differentiate between multiple sclerosis (MS) and neuromyelitis optica (NMO) using random-forest classification. METHODS: Ninety participants (25 patients with MS, 30 patients with NMO, and 35 healthy controls [HCs]) were studied in Tehran, Iran, and 54 (24 patients with MS, 20 patients with NMO, and 10 HCs) in Padua, Italy. Participants underwent brain T1 and T2/fluid-attenuated inversion recovery MRI...
November 2, 2016: Neurology
https://www.readbyqxmd.com/read/27803645/sources-of-variation-influencing-concordance-between-functional-mri-and-direct-cortical-stimulation-in-brain-tumor-surgery
#13
Melanie A Morrison, Fred Tam, Marco M Garavaglia, Gregory M T Hare, Michael D Cusimano, Tom A Schweizer, Sunit Das, Simon J Graham
Object: Preoperative functional magnetic resonance imaging (fMRI) remains a promising method to aid in the surgical management of patients diagnosed with brain tumors. For patients that are candidates for awake craniotomies, surgical decisions can potentially be improved by fMRI but this depends on the level of concordance between preoperative brain maps and the maps provided by the gold standard intraoperative method, direct cortical stimulation (DCS). There have been numerous studies of the concordance between fMRI and DCS using sensitivity and specificity measures, however the results are variable across studies and the key factors influencing variability are not well understood...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27802246/morphometry-analysis-of-basal-ganglia-structures-in-children-with-obstructive-sleep%C3%A2-apnea
#14
Jian Lv, Lin Shi, Lei Zhao, Jian Weng, Vincent C T Mok, Winnie C W Chu, Defeng Wang
BACKGROUND: Obstructive sleep apnea (OSA) affects both adults and children, likely mediated by the deficits of various brain regions. The association between structural alterations in the brain and OSA syndrome have been reported in adult patients, but the corresponding evidence for OSA children is still limited. OBJECTIVE: The proposed study aimed to investigate the structural alterations in the brain of children with OSA, with focus on basal ganglia structures...
October 6, 2016: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/27796591/commonly-preserved-and-species-specific-gyral-folding-patterns-across-primate-brains
#15
Xiao Li, Hanbo Chen, Tuo Zhang, Xiang Yu, Xi Jiang, Kaiming Li, Longchuan Li, Mir Jalil Razavi, Xianqiao Wang, Xintao Hu, Junwei Han, Lei Guo, Xiaoping Hu, Tianming Liu
Cortical folding pattern analysis is very important to understand brain organization and development. Since previous studies mostly focus on human brain cortex, the regularity and variability of cortical folding patterns across primate brains (macaques, chimpanzees and human) remain largely unknown. This paper presents a novel computational framework to identify common or unique gyral folding patterns in macaque, chimpanzee and human brains using magnetic resonance imaging (MRI) data. We quantitatively characterize gyral folding patterns via hinge numbers with cortical surfaces constructed from MRI data, and identify 6 common three-hinge gyral folds that exhibit consistent anatomical locations across these three species as well as 2 unique three hinges in macaque, 6 ones in chimpanzee and 14 ones in human...
October 31, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27789186/novel-gene-brain-structure-relationships-in-psychotic-disorder-revealed-using-parallel-independent-component-analyses
#16
Neeraj Tandon, Pranav Nanda, Jaya L Padmanabhan, Ian T Mathew, Shaun M Eack, Balaji Narayanan, Shashwath A Meda, Sarah E Bergen, Gualbert Ruaño, Andreas Windemuth, Mohan Kocherla, Tracey L Petryshen, Brett Clementz, John Sweeney, Carol Tamminga, Godfrey Pearlson, Matcheri S Keshavan
BACKGROUND: Schizophrenia, schizoaffective disorder, and psychotic bipolar disorder overlap with regard to symptoms, structural and functional brain abnormalities, and genetic risk factors. Neurobiological pathways connecting genes to clinical phenotypes across the spectrum from schizophrenia to psychotic bipolar disorder remain largely unknown. METHODS: We examined the relationship between structural brain changes and risk alleles across the psychosis spectrum in the multi-site Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) cohort...
October 24, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27780331/reduced-regional-cortical-thickness-rate-of-change-in-donepezil-treated-subjects-with-suspected-prodromal-alzheimer-s-disease
#17
Enrica Cavedo, Bruno Dubois, Olivier Colliot, Simone Lista, Bernard Croisile, Guy Louis Tisserand, Jacques Touchon, Alain Bonafe, Pierre J Ousset, Olivier Rouaud, Fréderic Ricolfi, Alain Vighetto, Florence Pasquier, Samantha Galluzzi, Christine Delmaire, Mathieu Ceccaldi, Nadine Girard, Stéphane Lehericy, Françoise Duveau, Marie Chupin, Marie Sarazin, Didier Dormont, Harald Hampel
OBJECTIVE: Cortical thinning, previously identified during prodromal stages of Alzheimer's disease (AD), is a "candidate" biomarker implemented in AD clinical therapy trials. We investigated the effect of donepezil treatment on cortical thickness in mild cognitively impaired subjects with the amnestic syndrome of the hippocampal type, a prodromal at-risk group for progression to AD dementia. METHODS: Data were from a longitudinal analysis of a community-based multicenter suspected prodromal AD cohort diagnosed by the Free and Cued Selective Reminding Test (81 donepezil vs 92 placebo) enrolled in a double-blind, randomized, placebo-controlled parallel group design using donepezil (10 mg/day)...
October 25, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27776388/the-effects-of-equine-assisted-activities-and-therapy-on-resting-state-brain-function-in-attention-deficit-hyperactivity-disorder-a-pilot-study
#18
Jae Hyun Yoo, Yunhye Oh, Byongsu Jang, Jihye Song, Jiwon Kim, Seonwoo Kim, Jiyoung Lee, Hye-Yeon Shin, Jeong-Yi Kwon, Yun-Hee Kim, Bumseok Jeong, Yoo-Sook Joung
Objective: Equine-assisted activities and therapy (EAA/T) have been used as adjunct treatment options for physical and psychosocial rehabilitation. However, the therapeutic effects on resting-state brain function have not yet been studied. The aim of this study is to investigate the effects of EAA/T on participants with attention-deficit/hyperactivity disorder (ADHD) by comparing resting-state functional magnetic resonance imaging (rs-fMRI) signals and their clinical correlates. Methods: Ten participants with ADHD participated in a 12-week EAA/T program without any medication...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27770270/gadolinium-induced-effects-on-mammalian-cell-motility-adherence-and-chromatin-structure
#19
Gabor Nagy, Viktoria Baksa, Alexandra Kiss, Melinda Turani, Gaspar Banfalvi
The toxicity of gadolinium is reduced by chelating agents that render this heavy metal into contrast complexes used for medical magnetic resonance imaging. However, the dissociation of gadolinium chelates is known to generate Gd(3+) ions, the cellular toxicity of which has not been tested in details. The cytotoxic effects of Gd(III) ions were evaluated by monitoring the proliferation, measuring the cellular motility and following chromatin changes in various cell lines upon Gd(3+) treatment. Measurements applied long-term scanning microscopy and a perfusion platform that replaced the medium with test solutions, bypassed physical contact with the cell culture during experiments, and provided uninterrupted high time-resolution time-lapse photomicrography for an extended period of time...
October 22, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27765741/mri-brain-volume-measurements-in-infantile-neuronal-ceroid-lipofuscinosis
#20
E H Baker, S W Levin, Z Zhang, A B Mukherjee
BACKGROUND AND PURPOSE: Infantile neuronal ceroid lipofuscinosis is a devastating neurodegenerative storage disease caused by palmitoyl-protein thioesterase 1 deficiency, which impairs degradation of palmitoylated proteins (constituents of ceroid) by lysosomal hydrolases. Consequent lysosomal ceroid accumulation leads to neuronal injury, resulting in rapid neurodegeneration and childhood death. As part of a project studying the treatment benefits of a combination of cysteamine bitartrate and N-acetyl cysteine, we made serial measurements of patients' brain volumes with MR imaging...
October 20, 2016: AJNR. American Journal of Neuroradiology
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