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Heather Dawson, Richard Kirsch, David K Driman, David E Messenger, Naziheh Assarzadegan, Robert H Riddell
Venous invasion (VI) is a well-established independent prognostic indicator in colorectal cancer (CRC). Its accurate detection is particularly important in stage II CRC as it may influence the decision to administer adjuvant therapy. The Royal College of Pathologists (RCPath) of the United Kingdom state that VI should be detected in at least 30% of CRC resection specimens. However, our experience in Ontario, Canada suggests that this (conservative) benchmark is rarely met. This article highlights the "Ontario experience" with respect to VI reporting and the key role that careful morphologic assessment, elastin staining and knowledge transfer has played in improving VI detection provincially and beyond...
2014: Frontiers in Oncology
B Chaffe, H Glencross, J Jones, J Staves, A Capps-Jenner, H Mistry, P Bolton-Maggs, M McQuade, D Asher
The SHOT Adverse Incident Reporting Scheme has consistently reported an unacceptably high level of errors originating in the laboratory setting. In 2006 an initiative was launched in conjunction with the IBMS, SHOT, RCPath, BBTS, UK NEQAS, the NHSE NBTC and the equivalents in Scotland, Wales and Northern Ireland that led to the formation of the UK TLC. The UK TLC in considering the nature and spread of the errors documented by SHOT concluded that a significant proportion of these errors were most likely to be related to either the use of information technology or staff education, staffing levels, skill mix, training and competency issues...
December 2014: Transfusion Medicine
Y L Woods, S Mukhtar, P McClements, J Lang, R J Steele, F A Carey
AIMS: The main purpose of the study was to present a baseline audit of reporting of colorectal cancers resection specimens in Scotland, audited against the Royal College of Pathologists (RCPath) standards (2007) and NHS Quality Improvement Scotland (NHS QIS) standards. METHODS: 50 consecutive rectal and 50 consecutive colonic cancer cases from 2011 were audited from 10 Scottish health boards involved in colorectal cancer reporting (n=953). The rates of reporting of serosal involvement, extramural venous invasion (EMVI) and the mean numbers of lymph nodes found were audited against RCPath standards and compared between units that routinely used a reporting proforma versus those that did not...
June 2014: Journal of Clinical Pathology
Joanne Horne, Adrian C Bateman, Norman J Carr, Isobel Ryder
The Royal College of Pathologists (RCPath) and College of American Pathologists recommend that at least 12 lymph nodes should be harvested for adequate staging of colorectal carcinoma. Just one nodal tumour deposit upstages the malignancy from pN0 to pN1. This is critically important as node-positive patients (pN1) are considered for adjuvant chemotherapy whereas node-negative patients (pN0) may not be. It is not always easy to harvest the required number, especially in patients with rectal carcinoma who may have received neoadjuvant therapy-an increasingly common treatment...
May 2014: Journal of Clinical Pathology
K I Abdul-Jalil, K M Sheehan, J Kehoe, R Cummins, A O'Grady, D A McNamara, J Deasy, O Breathnach, L Grogan, B D P O'Neill, C Faul, I Parker, E W Kay, B T Hennessy, P Gillen
AIM: To date, there is no uniform consensus on whether tumour regression grade (TRG) is predictive of outcome in rectal cancer. Furthermore, the lack of standardization of TRG grading is a major source of variability in published studies. The aim of this study was to evaluate the prognostic impact of TRG in a cohort of patients with locally advanced rectal cancer treated with neoadjuvant chemoradiation therapy (CRT). In addition to the Mandard TRG, we utilized four TRG systems modified from the Mandard TRG system and applied them to the cohort to assess which TRG system is most informative...
January 2014: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Richard A Scolyer, Meagan J Judge, Alan Evans, David P Frishberg, Victor G Prieto, John F Thompson, Martin J Trotter, Maureen Y Walsh, Noreen M G Walsh, David W Ellis
An accurate and complete pathology report is critical for the optimal management of cutaneous melanoma patients. Protocols for the pathologic reporting of melanoma have been independently developed by the Royal College of Pathologists of Australasia (RCPA), Royal College of Pathologists (United Kingdom) (RCPath), and College of American Pathologists (CAP). In this study, data sets, checklists, and structured reporting protocols for pathologic examination and reporting of cutaneous melanoma were analyzed by an international panel of melanoma pathologists and clinicians with the aim of developing a common, internationally agreed upon, evidence-based data set...
December 2013: American Journal of Surgical Pathology
Josephine Seale, Wael Elamin, Michael Millar
BACKGROUND: Training in microbiology is continuing to evolve. Standardisation of this process has, in part, been achieved through the development of a training curriculum by the Royal College of Pathologists (RCPath). A substantial proportion of microbiology training occurs through telephone consultations. AIMS: To ascertain the content of these interactions and the extent to which the necessary skills outlined by the curriculum are attainable via these consultations...
February 2014: Journal of Clinical Pathology
L Adamczyk, A Simpkin, J Oxley
AIMS: To look at the incidence of tip margin involvement in skin excisions for basal cell carcinomas (BCCs) and to examine if any factors might be used to predict margin involvement. METHODS AND RESULTS: All reports of BCCs by a single dermatopathologist were reviewed and 793 excisions were included from 642 patients. Whether there was BCC in the tip and whether this tip was involved were recorded together with macroscopic and microscopic factors based on the Royal College of Pathologists' (RCPath) dataset...
January 2014: Journal of Clinical Pathology
Jawad Ahmad, Maurice B Loughrey, David Donnelly, Lisa Ranaghan, Rajeev Shah, Giulio Napolitano, Andrew J Kennedy
AIMS: Involved circumferential resection margin (CRM) (R1) in oesophageal carcinoma (OC) has conflicting definitions. This study aimed to compare two such definitions applied to a cohort of OC resection specimens and also evaluated a novel three-tier CRM stratification. METHODS AND RESULTS: OC patients with pT3 disease were classified as R0 or R1 on the basis of Royal College of Pathologists (UK) (RCPath) and College of American Pathologists (CAP) criteria and group survivals were compared...
April 2013: Histopathology
Pelvender Singh Gill, Ian S D Roberts, Lisa Browning, Ranmith Perera, Anne Y Warren, Freddie C Hamdy, Clare Verrill
This article reviews previously described methods of fresh tissue sampling from radical prostatectomy specimens for research and describes a method used in Oxford which is simple, logical and cost effective. The method utilises a systematic zonal approach to tissue procurement in order to meet the increasing requirement for research samples with detailed morphological information such as zone of origin, tumour stage and Gleason grade. The described method involves punch biopsy sampling from a 4mm thick transverse slice cut 8mm superior to the apex...
December 2012: Journal of Clinical Pathology
Mickhaiel Barrow, Ian S D Roberts, Elizabeth J Soilleux
The authors audited the value of toxicology/histology and reporting standards in sudden death autopsy cases in individuals with epilepsy/seizures. Of 83 cases with epilepsy/seizures and no macroscopically obvious cause of death, 40 had no history of drug/alcohol abuse. Toxicological analysis was performed in 11/40 (28%) and did not contribute to the cause of death in any. Conversely, in individuals with epilepsy with known drug/alcohol abuse and cases with a history of seizures related to drug/alcohol abuse, toxicological analysis was performed in 17/22 (77%) and 14/21 (67%), contributing to the causes of death in 8/17 (47%) and 10/14 (71%), respectively...
November 2011: Journal of Clinical Pathology
David E Messenger, David K Driman, Robin S McLeod, Robert H Riddell, Richard Kirsch
AIMS: Venous invasion (VI) is a known independent prognostic indicator of recurrence and survival in colorectal cancer. The guidelines of the Royal College of Pathologists (RCPath) state that, in a series of resections, extramural VI should be detected in at least 25% of specimens. However, there is widespread variability in the reported incidence, and this may affect patient access to adjuvant therapy. This study aims to clarify the current practice patterns of pathologists regarding the assessment of VI and to identify factors associated with an increased self-reported VI detection rate...
November 2011: Journal of Clinical Pathology
Adrian C Bateman, Eleanor Jaynes, Andrew R Bateman
AIMS: To compare the utility and reproducibility of tumour regression grade scoring systems during histopathological assessment of rectal cancers resected after neoadjuvant (i.e. pre-operative) chemoradiotherapy. METHODS AND RESULTS: The histopathological features of tumour regression were assessed independently in 54 rectal cancer resection specimens using three scoring systems: the Tumour Regression Grade (TRG), modified Rectal Cancer Regression Grade (m-RCRG) and RCPath Cancer Dataset (RCPath) methods...
May 2009: Histopathology
Scott A Sanders, Richard A Carr, Sarah E Roberts
No abstract text is available yet for this article.
May 2009: Journal of Clinical Pathology
M J P Biggs, L J R Brown, P N Furness
AIMS: The Royal College of Pathologists (RCPath) has for several years published guidance on good autopsy practice. However, pressures such as time, cost and the introduction of the Human Tissue Act have generated suggestions that there is a discrepancy between the published guidelines and what can realistically be achieved in daily practice. The aims of this study were to determine the extent to which practising pathologists agree with this complaint, and what suggestions they might have for its resolution...
June 2009: Journal of Clinical Pathology
G J Horne, D F Barber, A K Bruecks, R T A Maung, M J Trotter
AIM: To measure pathologist workload in subspecialty dermatopathology. METHODS: Three subspecialty dermatopathologists, working in a university-affiliated laboratory, participated in a time-motion study during which they reported 2891 consecutive skin cases received from community-based dermatologists. All pathology reports were retrospectively reviewed and workload measured using the Royal College of Pathologists (RCPath) guidelines and the level 4 equivalent (L4E) method...
May 2009: Journal of Clinical Pathology
R A Carr, D S A Sanders, O P Stores, F A Smew, M E Parkes, V Ross-Gilbertson, N Chachlani, J Simon
BACKGROUND: Guidelines on staffing and workload for histopathology and cytopathology departments was published by the Royal College of Pathologists (RCPath) in July 2003. In this document, a system is provided whereby the workload of a cellular pathology department and individual pathologists can be assessed with a scoring system based on specialty and complexity of the specimens. A similar, but simplified, system of scoring specimens by specialty was developed in the Warwick District General Hospital...
August 2006: Journal of Clinical Pathology
S S Cross, J L Stone
AIMS: To investigate the effect on the workload of a gastrointestinal pathology service of implementing the recommendations of the Royal College of Pathologists' (RCPath) working party on specimens of limited or no clinical value (LONCV). METHODS: All endoscopic gastrointestinal pathology reports for the first three months of 2001 at a large teaching hospital were reviewed against the RCPath recommendations. Specimens in the category of LONCV were recorded and the final histopathology diagnosis noted...
November 2002: Journal of Clinical Pathology
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